locus-tag class description CRN75_00010 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CRN75_00015 ENOG410667J hydrolase CRN75_00025 ENOG4105C7B Threonine dehydratase CRN75_00030 ENOG4108SGR YheO domain-containing protein CRN75_00040 ENOG41090BB DNA mismatch endonuclease (vsr) CRN75_00050 ENOG4105D99 atp gtp-binding protein CRN75_00055 ENOG4105R2A (LipO)protein CRN75_00075 ENOG4105JKW Valine--pyruvate aminotransferase CRN75_00080 ENOG4107T9C Alpha amylase catalytic region CRN75_00120 ENOG4108R3E Dna-3-methyladenine glycosylase i CRN75_00130 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CRN75_00135 ENOG4106JH6 (LipO)protein CRN75_00140 ENOG4105CTS PTS system mannitol-specific CRN75_00145 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase CRN75_00150 ENOG4105E61 Mannitol repressor protein CRN75_00160 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CRN75_00165 ENOG4108YYI Protein of unknown function (DUF2810) CRN75_00180 ENOG4108RPX mosc domain containing protein CRN75_00185 ENOG4105C8Q Methyl-accepting chemotaxis CRN75_00190 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CRN75_00195 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CRN75_00200 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CRN75_00205 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CRN75_00210 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CRN75_00215 ENOG4108MG3 formate dehydrogenase CRN75_00220 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) CRN75_00225 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) CRN75_00230 ENOG4105EM7 Selenocysteine-specific translation elongation factor CRN75_00240 ENOG4105MEV Acyl-transferase CRN75_00255 ENOG4105CMG Carbohydrate kinase CRN75_00260 ENOG4105C93 Xylose Isomerase CRN75_00265 ENOG4105DFW ABC transporter CRN75_00275 ENOG4107RNG ABC transporter CRN75_00280 ENOG4105T16 Transcriptional regulator (AraC family) CRN75_00285 ENOG4105DFP Integrase CRN75_00300 ENOG4105ZTC transcriptional activator, Ogr delta CRN75_00340 ENOG4105CDU Replicative dna helicase CRN75_00355 ENOG4105CGP Urocanate hydratase CRN75_00360 ENOG4105C84 Histidine ammonia-lyase CRN75_00365 ENOG4105C85 amino acid CRN75_00395 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CRN75_00400 ENOG4105CKK Glycosyl transferase, family 2 CRN75_00410 ENOG4105FAW cDP-glucose 4,6-dehydratase CRN75_00420 ENOG4105K56 Transcriptional regulator CRN75_00425 ENOG4108ZHJ Organic hydroperoxide resistance protein CRN75_00430 ENOG4105DIJ Phosphoethanolamine transferase CRN75_00435 ENOG4108KX4 response regulator CRN75_00440 ENOG4105BZU Histidine kinase CRN75_00445 ENOG4105CXY transporter CRN75_00460 ENOG4105D5K Hemolysin activator protein CRN75_00465 ENOG4105CKT filamentous hemagglutinin CRN75_00475 ENOG4105DEF Extracellular solute-binding protein, family 5 CRN75_00480 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CRN75_00485 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CRN75_00490 ENOG4105C3U ABC transporter CRN75_00495 ENOG4108JQ7 (ABC) transporter CRN75_00500 ENOG4105D1V cellulose synthase operon protein YhjU CRN75_00505 ENOG4105WQA Cellulose biosynthesis protein BcsF CRN75_00510 ENOG4105U74 cellulose biosynthesis protein BcsE CRN75_00520 ENOG4105UTS cellulose synthase operon protein YhjQ CRN75_00530 ENOG4107EEX Cellulose synthase regulator protein CRN75_00535 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) CRN75_00540 ENOG4105EJG cellulose synthase CRN75_00545 ENOG4105BZU Histidine kinase CRN75_00550 ENOG4108PU9 oligogalacturonate-specific porin CRN75_00565 ENOG4105CK2 sodium dicarboxylate symporter CRN75_00570 ENOG4105CS0 peptidase CRN75_00575 ENOG4107SS6 2-dehydro-3-deoxygluconokinase CRN75_00580 ENOG4105VSH 4-oxalocrotonate tautomerase CRN75_00585 ENOG4105CMB EAL domain-containing protein CRN75_00590 ENOG41066T0 asmA family CRN75_00595 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) CRN75_00600 ENOG4107H3J ribonuclease CRN75_00610 ENOG4105DC8 reductase CRN75_00615 ENOG4105D6S protein involved in catabolism of external DNA CRN75_00625 ENOG4105DGW oligopeptidase A CRN75_00630 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) CRN75_00645 ENOG4108M6U Universal stress protein A CRN75_00650 ENOG4108V6B universal stress protein B CRN75_00655 ENOG4105CJ3 phosphate transporter CRN75_00660 ENOG4105CBX hi0933 family CRN75_00665 ENOG41066YJ Beta-lactamase CRN75_00680 ENOG4105CR8 Transcriptional regulator CRN75_00685 ENOG4105EQ0 Major Facilitator superfamily CRN75_00700 ENOG4105C26 Dehydrogenase CRN75_00705 ENOG4105DH8 myo-inositol catabolism CRN75_00715 ENOG4105EDK PfkB domain protein CRN75_00725 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CRN75_00730 ENOG4105F0H myo-inositol catabolism protein CRN75_00735 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CRN75_00740 ENOG4105WCN acetyltransferase CRN75_00745 ENOG4105C2I pirin domain protein CRN75_00750 ENOG4105DIQ Transcriptional regulator CRN75_00755 ENOG4105C6Z Gluconate CRN75_00760 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CRN75_00765 ENOG41076UM multiple antibiotic resistance (MarC)-related protein CRN75_00770 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CRN75_00780 ENOG4107R0E Glycosyl transferase, family 2 CRN75_00795 ENOG4108MBX Secretion Protein CRN75_00805 ENOG4105C7K acetolactate synthase CRN75_00820 ENOG4108HRK Histidine kinase CRN75_00825 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CRN75_00830 ENOG4108IUM Glycogen debranching enzyme CRN75_00840 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CRN75_00845 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CRN75_00850 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CRN75_00865 ENOG4105E98 transcriptional regulator DeoR family CRN75_00870 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) CRN75_00885 ENOG41061ZR Transcriptional regulator CRN75_00890 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CRN75_00895 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) CRN75_00900 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) CRN75_00905 ENOG4105MJ2 Competence protein CRN75_00910 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CRN75_00915 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) CRN75_00920 ENOG4105CE1 Ferrous iron transport protein b CRN75_00925 ENOG4105XFK Ferrous iron transport protein A CRN75_00930 ENOG4105BZM domain protein CRN75_00935 ENOG4108RRZ Transcription elongation factor GreB CRN75_00940 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CRN75_00945 ENOG4105E0F Histidine kinase CRN75_00960 ENOG4105VEJ Heat shock protein CRN75_00965 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 CRN75_00970 ENOG4105DQY intracellular growth attenuator CRN75_00975 ENOG4107RK2 ADP-ribose diphosphatase NudE CRN75_00980 ENOG4108JQC penicillin-binding protein 1A CRN75_01005 ENOG4105E4G Type IV pilus CRN75_01010 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CRN75_01030 ENOG4105DJV ribulose-phosphate 3-epimerase CRN75_01040 ENOG4105C31 Tryptophanyl-tRNA synthetase CRN75_01045 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CRN75_01050 ENOG4107V9H nitrite transporter CRN75_01055 ENOG4105WZK nitrite reductase NADPH small subunit CRN75_01060 ENOG4107QZF nitrite reductase NADPH large subunit CRN75_01065 ENOG4105DZC cytosine deaminase CRN75_01070 ENOG4106DTQ Protein TsgA homolog CRN75_01080 ENOG4107RNH Outer membrane receptor FepA CRN75_01085 ENOG41060NJ transcriptional regulator CRN75_01090 ENOG4105F8D glycoside hydrolase family 4 CRN75_01100 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CRN75_01110 ENOG4105D7A ATP-binding protein CRN75_01120 ENOG4105C8Y Acetylornithine aminotransferase CRN75_01125 ENOG410613R integral membrane protein, YccS YhfK family CRN75_01135 ENOG4108UKZ OsmC family CRN75_01140 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) CRN75_01145 ENOG4105YP7 UPF0270 protein CRN75_01150 ENOG4105DNZ Alpha Beta Hydrolase CRN75_01160 ENOG4105JAB phenazine biosynthesis protein, phzf family CRN75_01165 ENOG4106FTQ Taurine ABC transporter, periplasmic CRN75_01175 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CRN75_01180 ENOG4105E2B Taurine dioxygenase CRN75_01190 ENOG4105C5H ABC transporter CRN75_01195 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CRN75_01205 ENOG4105VKU nucleicacid-binding protein CRN75_01210 ENOG4108YZY peptidylprolyl cis-trans isomerase CRN75_01220 ENOG4108V1T peptidylprolyl cis-trans isomerase CRN75_01225 ENOG4105WWK YheO domain protein CRN75_01240 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CRN75_01250 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CRN75_01265 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CRN75_01285 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CRN75_01295 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CRN75_01300 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CRN75_01305 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CRN75_01310 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CRN75_01315 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CRN75_01320 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CRN75_01325 ENOG41083MP 50s ribosomal protein l29 CRN75_01330 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CRN75_01345 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CRN75_01350 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CRN75_01360 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CRN75_01375 ENOG4105VPB 50S ribosomal protein L30 CRN75_01380 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CRN75_01385 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CRN75_01390 ENOG41067V7 50S ribosomal protein L36 CRN75_01395 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CRN75_01400 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CRN75_01405 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CRN75_01410 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CRN75_01415 ENOG4108ZT0 50S ribosomal protein l17 CRN75_01420 ENOG4105VTS DnaJ-like, subfamily C CRN75_01425 ENOG4105W1Y Transcriptional regulator CRN75_01430 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system CRN75_01435 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CRN75_01440 ENOG4105C1A potassium transporter peripheral membrane CRN75_01445 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CRN75_01450 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CRN75_01455 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CRN75_01460 ENOG4105C79 DNA protecting protein DprA CRN75_01470 ENOG4108WI1 Dna topoisomerase CRN75_01475 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CRN75_01480 ENOG4105E2X shikimate dehydrogenase CRN75_01485 ENOG4108Z0R Transferase CRN75_01525 ENOG4105CVG Homoserine O-transsuccinylase CRN75_01530 ENOG4107QP3 malate synthase g CRN75_01535 ENOG4108I9X Isocitrate lyase CRN75_01540 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) CRN75_01545 ENOG4105CHU acetyl-coa acetyltransferase CRN75_01550 ENOG4105CRW Short chain fatty acid transporter CRN75_01555 ENOG4107QNJ CoA-transferase subunit B CRN75_01560 ENOG4107QP7 CoA-transferase subunit A CRN75_01565 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CRN75_01570 ENOG4105BZU Histidine kinase CRN75_01575 ENOG41069M3 Transcriptional regulator CRN75_01580 ENOG4105C3R Methionine synthase CRN75_01595 ENOG4105C09 Bile acid CRN75_01600 ENOG4105CFH Aspartokinase CRN75_01615 ENOG4105EG2 ABC transporter, permease CRN75_01620 ENOG4105D56 permease protein CRN75_01625 ENOG4107FKK extracellular solute-binding protein family 1 CRN75_01640 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CRN75_01645 ENOG4107W52 maltose operon periplasmic protein CRN75_01655 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) CRN75_01665 ENOG4105E55 glycerol-3-phosphate acyltransferase CRN75_01670 ENOG41080IJ Diacylglycerol kinase CRN75_01675 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CRN75_01680 ENOG4105VDW Csbd family CRN75_01685 ENOG4105MYN Zinc uptake regulation protein CRN75_01690 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CRN75_01695 ENOG4105P4Z Phage shock protein G CRN75_01700 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CRN75_01705 ENOG4105CDU Replicative dna helicase CRN75_01710 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CRN75_01715 ENOG4105CGF Aromatic amino acid aminotransferase CRN75_01720 ENOG4105MSB protein, conserved in bacteria CRN75_01725 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CRN75_01730 ENOG4108UUM single-stranded DNA-binding protein CRN75_01740 ENOG4105C7N Xanthine uracil vitamin C permease CRN75_01750 ENOG4105EEQ Na H antiporter CRN75_01755 ENOG4105CMU LysR family (Transcriptional regulator CRN75_01780 ENOG4105CDA abc transporter atp-binding protein CRN75_01785 ENOG4105DRP amino acid AbC transporter CRN75_01790 ENOG4105EZ7 amino acid ABC transporter CRN75_01805 ENOG4105D1S lipid A biosynthesis CRN75_01810 ENOG4107QPK )-transporter CRN75_01815 ENOG4105VEQ Cold shock protein CRN75_01820 ENOG4105VEQ Cold shock protein CRN75_01825 ENOG4105VEQ Cold shock protein CRN75_01830 ENOG4108XTF Outer Membrane Lipoprotein CRN75_01835 ENOG4105BZU Histidine kinase CRN75_01840 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) CRN75_01845 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CRN75_01850 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CRN75_01855 ENOG4108IA2 Sodium pantothenate symporter CRN75_01860 ENOG4105RG0 Membrane CRN75_01865 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CRN75_01870 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CRN75_01875 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CRN75_01880 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) CRN75_01890 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family CRN75_01895 ENOG41062P1 Diguanylate cyclase phosphodiesterase CRN75_01900 ENOG4105DFF Rod shape-determining protein mreb CRN75_01905 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CRN75_01910 ENOG4105VQ7 Rod shape-determining protein MreD CRN75_01920 ENOG4105C03 ribonuclease CRN75_01925 ENOG4105QD6 exported protein CRN75_01935 ENOG4105D1U peptidase U62 modulator of DNA gyrase CRN75_01940 ENOG4105CR8 Transcriptional regulator CRN75_01945 ENOG4105ZQC membrane protein AaeX CRN75_01950 ENOG4105Y49 secretion protein, HlyD family CRN75_01955 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) CRN75_01970 ENOG4105UNR (Barnase) inhibitor CRN75_01975 ENOG4105N42 UPF0307 protein CRN75_01980 ENOG4105CMS peptidase U62, modulator of DNA gyrase CRN75_01990 ENOG4108XVM Cytochrome b(562) CRN75_01995 ENOG4105NXH GreA GreB family elongation factor CRN75_02025 ENOG41069H0 dihydroorotase EC 3.5.2.3 CRN75_02040 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CRN75_02045 ENOG4105EMD TRANSCRIPTIONal CRN75_02050 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CRN75_02055 ENOG4105D4X repressor CRN75_02060 ENOG4105C5Y PTS System CRN75_02065 ENOG4105CG3 alpha amylase, catalytic region CRN75_02090 ENOG4105KME endoribonuclease L-psp CRN75_02095 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) CRN75_02100 ENOG4105CXT aspartate transcarbamylase CRN75_02105 ENOG41080Z8 PHOSPHOCARRIER protein CRN75_02110 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CRN75_02115 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN CRN75_02120 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA CRN75_02125 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CRN75_02130 ENOG4108IUZ ABC transporter CRN75_02135 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA CRN75_02140 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) CRN75_02145 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase CRN75_02150 ENOG4105C2X Arabinose 5-phosphate isomerase CRN75_02155 ENOG4105FEU K -dependent Na -Ca exchanger CRN75_02160 ENOG4105DHJ ABC, transporter CRN75_02165 ENOG4105CY3 ABC transporter, permease CRN75_02170 ENOG4107PE3 Mammalian cell entry related domain protein CRN75_02175 ENOG4105E3I toluene tolerance CRN75_02180 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane CRN75_02185 ENOG4105VFK BolA family CRN75_02190 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CRN75_02195 ENOG4105C0H protease CRN75_02200 ENOG4105C0H protease CRN75_02205 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III CRN75_02210 ENOG4105D6Z AFG1 family ATPase CRN75_02215 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CRN75_02220 ENOG4108UJD 30S ribosomal protein S9 CRN75_02225 ENOG4107MKT Stringent starvation protein a CRN75_02230 ENOG4105KB2 stringent starvation protein b CRN75_02240 ENOG4105BZ8 glutamate synthase CRN75_02245 ENOG4105CBC glutamate synthase CRN75_02250 ENOG4105N5T Radical SAM Protein CRN75_02255 ENOG4105BZU Histidine kinase CRN75_02265 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain CRN75_02270 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase CRN75_02275 ENOG4105W4M Transport-associated protein CRN75_02280 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CRN75_02285 ENOG41082RQ UPF0102 protein CRN75_02295 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CRN75_02320 ENOG4105EQ2 LysR family Transcriptional regulator CRN75_02325 ENOG4107SET aldo keto reductase CRN75_02345 ENOG4105DQ4 alcohol dehydrogenase CRN75_02350 ENOG4108CNN domain protein CRN75_02355 ENOG4105CWB LysR family transcriptional Regulator CRN75_02360 ENOG4105CHF Glutathione S-transferase CRN75_02365 ENOG4108VBZ doxx family CRN75_02370 ENOG4105YJD CRN75_02375 ENOG41090KG Inner membrane protein YqjE CRN75_02380 ENOG4105NE1 Conserved Protein CRN75_02395 ENOG4106W5V Membrane CRN75_02410 ENOG4105DPW Major facilitator superfamily MFS_1 CRN75_02415 ENOG4105D2H Uronic isomerase CRN75_02420 ENOG4107QZW Altronate oxidoreductase CRN75_02425 ENOG4105CTX dehydratase CRN75_02430 ENOG4105P66 Membrane CRN75_02435 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) CRN75_02440 ENOG4105DU1 integral membrane protein, terc CRN75_02445 ENOG4105EE0 oxidoreductase CRN75_02450 ENOG4108VKG metal-dependent hydrolase CRN75_02460 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) CRN75_02465 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CRN75_02475 ENOG4105D29 Helix-turn-helix type 11 domain protein CRN75_02480 ENOG4108YK4 Acid-resistance membrane protein CRN75_02490 ENOG4105CVK Glutamate decarboxylase CRN75_02495 ENOG4105E5D amino acid CRN75_02500 ENOG4105CSV Glutaminase CRN75_02505 ENOG4105C5Y PTS System CRN75_02510 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CRN75_02515 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) CRN75_02520 ENOG4105D17 glycoside hydrolase, family 3 domain protein CRN75_02530 ENOG4105EHZ conserved protein UCP016719 CRN75_02540 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CRN75_02545 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CRN75_02550 ENOG4105VCC 30S ribosomal protein S21 CRN75_02555 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CRN75_02560 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CRN75_02565 ENOG4107ZVW dihydroneopterin aldolase CRN75_02570 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CRN75_02575 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CRN75_02580 ENOG4106MWK domain protein CRN75_02585 ENOG4105I7R Adenylate cyclase CRN75_02590 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CRN75_02595 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CRN75_02600 ENOG4105DVH amino acid CRN75_02605 ENOG4105W0Z cytoplasmic protein CRN75_02610 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CRN75_02615 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CRN75_02620 ENOG4106032 Glutathionylspermidine synthase CRN75_02625 ENOG4105F1G UPF0441 protein CRN75_02630 ENOG4105DFG type I secretion outer membrane protein CRN75_02635 ENOG41087AY ADP-Ribose pyrophosphatase CRN75_02640 ENOG4108SX3 cytoplasmic protein CRN75_02645 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CRN75_02650 ENOG4105IPS esterase CRN75_02655 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CRN75_02660 ENOG4105JQN Transcriptional regulator CRN75_02665 ENOG4105VRH Antibiotic biosynthesis monooxygenase CRN75_02670 ENOG4105NF4 modulator of drug activity CRN75_02685 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CRN75_02690 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase CRN75_02695 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) CRN75_02705 ENOG4105CV8 reductase CRN75_02710 ENOG4108I6A alcohol dehydrogenase CRN75_02715 ENOG4105CF7 AraC family transcriptional regulator CRN75_02720 ENOG4108K81 inner membrane protein YghB CRN75_02725 ENOG4105C28 cystathionine CRN75_02730 ENOG4105CWK Biopolymer transport protein, ExbB CRN75_02735 ENOG4108ZZF transport protein (ExbD) CRN75_02800 ENOG4105CF1 Alkylated DNA repair protein CRN75_02805 ENOG4108IJF Heavy metal efflux pump, CzcA CRN75_02810 ENOG4105EP1 Efflux transporter rnd family, mfp subunit CRN75_02830 ENOG4105E0K tonB-dependent siderophore receptor CRN75_02840 ENOG4105WQT MbtH domain protein CRN75_02845 ENOG4105CEY Amp-dependent synthetase and ligase CRN75_02855 ENOG4105E0A ABC, transporter CRN75_02860 ENOG4105TVJ transport system, permease CRN75_02865 ENOG4105DQ5 transport system permease protein CRN75_02870 ENOG4105E8G Major facilitator Superfamily CRN75_02875 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein CRN75_02880 ENOG4105E4F Isochorismate synthase CRN75_02885 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CRN75_02890 ENOG4105WQI isochorismatase CRN75_02895 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CRN75_02900 ENOG4105C0W non-ribosomal peptide synthetase CRN75_02905 ENOG4105C8Q Methyl-accepting chemotaxis CRN75_03005 ENOG4108XTF Outer Membrane Lipoprotein CRN75_03010 ENOG4105E3S small subunit CRN75_03015 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CRN75_03020 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit CRN75_03025 ENOG4105DPX Hydrogenase, large subunit CRN75_03030 ENOG4108USZ hydrogenase CRN75_03035 ENOG4108WGS hydrogenase 2-specific chaperone CRN75_03040 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CRN75_03045 ENOG4107RSS Hydrogenase accessory protein HypB CRN75_03050 ENOG41082MF Hydrogenase assembly chaperone hypC hupF CRN75_03055 ENOG4105CQS hydrogenase expression formation protein HypD CRN75_03060 ENOG4105C45 hydrogenase expression formation protein (HypE) CRN75_03065 ENOG4105C8H hydrogenase maturation protein Hypf CRN75_03070 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase CRN75_03085 ENOG4105C1P efflux transporter, rnd family, mfp subunit CRN75_03095 ENOG4105C85 amino acid CRN75_03100 ENOG4105CPD ethanolamine ammonia-lyase CRN75_03105 ENOG4107FQ9 ethanolamine ammonia-lyase CRN75_03110 ENOG4105CSH Transporter CRN75_03135 ENOG4105CFC Transporter CRN75_03140 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CRN75_03145 ENOG4105EAM Na Pi-cotransporter CRN75_03155 ENOG4105ETE Transcriptional regulator (LacI family CRN75_03165 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CRN75_03190 ENOG4105CM4 permease protein CRN75_03195 ENOG4108IPW abc transporter atp-binding protein CRN75_03200 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CRN75_03220 ENOG4105J12 Multidrug resistance protein mdtN CRN75_03225 ENOG4108MI0 Resistance protein CRN75_03265 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CRN75_03375 ENOG4105CT4 transporter CRN75_03390 ENOG4108S1B Periplasmic chaperone protein CRN75_03405 ENOG4108WDE Fimbrial protein CRN75_03410 ENOG4105CW0 outer membrane usher protein CRN75_03415 ENOG4105GQR Chaperone CRN75_03425 ENOG4106KR7 LysR family Transcriptional regulator CRN75_03430 ENOG4105KBH arsR family transcriptional regulator CRN75_03445 ENOG4105PGM cation diffusion facilitator family transporter CRN75_03455 ENOG4108IQE Amp-dependent synthetase and ligase CRN75_03465 ENOG4105CHR reductase CRN75_03480 ENOG4108VKM cytochrome b561 CRN75_03485 ENOG4108XDN Transcriptional regulator CRN75_03510 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CRN75_03525 ENOG4105BZU Histidine kinase CRN75_03545 ENOG4105TNG K13735 adhesin invasin CRN75_03550 ENOG4107XBN GntR Family Transcriptional Regulator CRN75_03555 ENOG4105DEI Mannitol dehydrogenase CRN75_03565 ENOG4105CPQ Dehydrogenase CRN75_03570 ENOG4105CXK mandelate racemase muconate lactonizing CRN75_03590 ENOG4105QAX Iron-sulfur CRN75_03595 ENOG4108J2R molybdopterin oxidoreductase CRN75_03615 ENOG4105CXN decarboxylase CRN75_03625 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division CRN75_03635 ENOG4105CEN a g-specific adenine glycosylase CRN75_03640 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CRN75_03645 ENOG41090ED Protein with unknown function (DUF469) CRN75_03650 ENOG4105CSV Glutaminase CRN75_03655 ENOG4105K33 Periplasmic Protein CRN75_03660 ENOG4105CSA Coproporphyrinogen iii oxidase CRN75_03665 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CRN75_03670 ENOG4105VZ9 UPF0235 protein CRN75_03675 ENOG4108VIA integral membrane protein CRN75_03680 ENOG4105II7 pyrroline-5-carboxylate reductase CRN75_03685 ENOG4105DFA alanine racemase domain protein CRN75_03690 ENOG4105CZX twitching motility protein CRN75_03700 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) CRN75_03705 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CRN75_03710 ENOG4108UJU UPF0301 protein CRN75_03715 ENOG4108MGN ATP-binding component of a transport system CRN75_03720 ENOG4105D7Z glutathione synthase CRN75_03725 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CRN75_03730 ENOG4105RWS endonuclease I CRN75_03735 ENOG4105GPY SprT protein CRN75_03740 ENOG41080HT Transcriptional regulator, arsr family CRN75_03760 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) CRN75_03770 ENOG4108K0D peptidase, M48 CRN75_03775 ENOG4105CV1 Transketolase (EC 2.2.1.1) CRN75_03780 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CRN75_03785 ENOG4105BZA Phosphoglycerate kinase CRN75_03790 ENOG4105D2N Aldolase CRN75_03800 ENOG4105D64 Mechanosensitive ion channel CRN75_03805 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CRN75_03810 ENOG4105MPN Membrane CRN75_03815 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CRN75_03820 ENOG4105E66 phosphoriboisomerase A CRN75_03825 ENOG4108JQ1 Dehydrogenase CRN75_03830 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CRN75_03845 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CRN75_03855 ENOG4105E07 UPF0149 protein CRN75_03860 ENOG4107RAQ aminopeptidase CRN75_03865 ENOG4105D0A hydroxylase CRN75_03870 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CRN75_03875 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CRN75_03880 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CRN75_03885 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CRN75_03900 ENOG4108UT2 hemolysin iii CRN75_03905 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CRN75_03910 ENOG4105Y75 tpr repeat protein CRN75_03920 ENOG4105E3W Two component transcriptional regulator (Winged helix family CRN75_03925 ENOG4105EB3 Histidine kinase CRN75_03930 ENOG4105CT7 inner membrane cred family protein CRN75_03935 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) CRN75_03940 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CRN75_03945 ENOG4105T95 Thiol disulfide interChange protein CRN75_03950 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CRN75_03985 ENOG4105EFX secretion protein, HlyD family CRN75_03990 ENOG4105KK7 inner membrane protein YiaW CRN75_03995 ENOG4105BZU Histidine kinase CRN75_04000 ENOG4105F7P transcriptional regulator AsnC family CRN75_04015 ENOG4105DPW Major facilitator superfamily MFS_1 CRN75_04020 ENOG4105CQ4 Transcriptional regulator CRN75_04025 ENOG4105DVC DnaJ domain protein CRN75_04035 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CRN75_04040 ENOG4105KVH Transcriptional regulator CRN75_04045 ENOG4107B2H carbonic anhydrase CRN75_04065 ENOG4107QHF type ii secretion system protein e CRN75_04070 ENOG4105D7Q type ii secretion system CRN75_04125 ENOG4105C8Q Methyl-accepting chemotaxis CRN75_04140 ENOG4105EJC lysr family transcriptional regulator CRN75_04145 ENOG4105F27 Major Facilitator CRN75_04150 ENOG4105RQF LysR family Transcriptional regulator CRN75_04155 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CRN75_04160 ENOG4105DDV Transcriptional regulator (LacI family CRN75_04165 ENOG41060NJ transcriptional regulator CRN75_04175 ENOG4105CEY Amp-dependent synthetase and ligase CRN75_04180 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) CRN75_04185 ENOG4105CPC Aldo Keto reductase CRN75_04195 ENOG4105EE5 Membrane protein terC CRN75_04200 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) CRN75_04210 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CRN75_04215 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase CRN75_04220 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CRN75_04225 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CRN75_04250 ENOG4105DSY exodeoxyribonuclease V, gamma CRN75_04255 ENOG4107QXK peptidase CRN75_04260 ENOG4107QKA exodeoxyribonuclease V beta CRN75_04265 ENOG4107QYX exodeoxyribonuclease v alpha CRN75_04270 ENOG4107QZM n-acetylglutamate synthase CRN75_04275 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CRN75_04295 ENOG4105CA3 membrane-bound lytic murein transglycosylase CRN75_04300 ENOG4105CUZ uba thif-type nad fad binding protein CRN75_04305 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CRN75_04310 ENOG4105C9B Cysteine desulfurase CRN75_04315 ENOG4105M5B (LipO)protein CRN75_04320 ENOG4105ETT transcriptional Regulator, LysR family CRN75_04325 ENOG4105M08 Membrane CRN75_04330 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) CRN75_04335 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease CRN75_04345 ENOG4105EWT decarboxylase family CRN75_04350 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CRN75_04355 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) CRN75_04365 ENOG4105WP7 tRNA pseudouridine synthase C CRN75_04370 ENOG4105DR9 pseudouridine synthase CRN75_04375 ENOG4105QDK Flavodoxin CRN75_04385 ENOG4108T8E UPF0325 protein CRN75_04390 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) CRN75_04395 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) CRN75_04400 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CRN75_04410 ENOG4105CE9 30S ribosomal protein S2 CRN75_04415 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CRN75_04420 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CRN75_04425 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CRN75_04430 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CRN75_04435 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CRN75_04440 ENOG4105KNE Phosphatidate cytidylyltransferase CRN75_04445 ENOG4105DZP Membrane-associated zinc metalloprotease CRN75_04455 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) CRN75_04465 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CRN75_04470 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CRN75_04475 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CRN75_04480 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CRN75_04485 ENOG4105C0B DNA polymerase III (alpha subunit) CRN75_04490 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CRN75_04495 ENOG4105CXN decarboxylase CRN75_04500 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CRN75_04505 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CRN75_04510 ENOG4106RE7 Cytochrome CRN75_04515 ENOG4105M1T rho-binding antiterminator CRN75_04525 ENOG4108VWS Yaeq family CRN75_04530 ENOG4108YZN class I peptide chain release factor CRN75_04535 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion CRN75_04540 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CRN75_04550 ENOG4108R96 Methyltransferase, YaeB family CRN75_04555 ENOG4108R8X outer membrane lipoprotein CRN75_04560 ENOG4105D01 (LipO)protein CRN75_04565 ENOG4108UMI ABC transporter, permease CRN75_04575 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CRN75_04630 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CRN75_04690 ENOG4105C2D reductase CRN75_04695 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CRN75_04700 ENOG4105CV8 reductase CRN75_04705 ENOG4105HEI LysR family (Transcriptional regulator CRN75_04710 ENOG4105F27 Major Facilitator CRN75_04715 ENOG4107NA1 Endonuclease Exonuclease phosphatase CRN75_04720 ENOG4105E9H Lytic Murein transglycosylase CRN75_04725 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CRN75_04730 ENOG4105D1A Methyltransferase CRN75_04735 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CRN75_04740 ENOG4108JDX DNA polymerase iii, epsilon subunit CRN75_04750 ENOG4105GIJ Glycine betaine CRN75_04755 ENOG4108HQS Glycine betaine CRN75_04760 ENOG4108IJ7 Glycine betaine CRN75_04765 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CRN75_04775 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CRN75_04780 ENOG4105WAZ (Glutaredoxin-like protein) NrdH CRN75_04790 ENOG4105TNS Conserved Protein CRN75_04810 ENOG4106PHM regulatory protein CRN75_04815 ENOG4108WMJ Protein of unknown function (DUF2002) CRN75_04820 ENOG4108SAJ Protein of unknown function (DUF1198) CRN75_04830 ENOG4105VEQ Cold shock protein CRN75_04860 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CRN75_04865 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CRN75_04870 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CRN75_04875 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) CRN75_04890 ENOG4105KI2 Urea amidohydrolase subunit beta CRN75_04895 ENOG4105CQM Urea amidohydrolase subunit alpha CRN75_04910 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CRN75_04930 ENOG4105XXV Acid-resistance protein CRN75_04935 ENOG4107SVH Potassium channel protein CRN75_04940 ENOG41086WQ Protein CrcB homolog CRN75_04950 ENOG4105CPC Aldo Keto reductase CRN75_04955 ENOG4105D8V Glucose sorbosone dehydrogenase CRN75_04960 ENOG4105VZJ PTS System CRN75_04965 ENOG4105CK1 PTS System CRN75_04970 ENOG4105CS2 ec 3.2.1.21 CRN75_04975 ENOG4105VCP PTS System CRN75_04980 ENOG4105EZV Transcriptional regulator CRN75_04985 ENOG410901P UPF0249 protein CRN75_04995 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CRN75_05000 ENOG4105CSP Major Facilitator Superfamily CRN75_05005 ENOG4105CTX dehydratase CRN75_05035 ENOG4108Z1B Cyclase dehydrase CRN75_05045 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CRN75_05050 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CRN75_05055 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CRN75_05060 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CRN75_05065 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CRN75_05070 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) CRN75_05085 ENOG4105C1J atp-dependent rna helicase CRN75_05090 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) CRN75_05095 ENOG4108IYU L-aspartate oxidase CRN75_05105 ENOG41069PW sigma-e factor negative regulatory protein CRN75_05110 ENOG4105VQK sigma E regulatory protein, MucB RseB CRN75_05115 ENOG4105WMJ Positive regulator of sigma E, RseC MucC CRN75_05125 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CRN75_05130 ENOG4105C3F Signal peptidase i CRN75_05140 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CRN75_05145 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) CRN75_05165 ENOG4107EFN gluconate transport system permease 3 CRN75_05170 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding CRN75_05175 ENOG4106G6Q Transcriptional regulator CRN75_05185 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB CRN75_05195 ENOG4108Z6B deaminase CRN75_05200 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) CRN75_05225 ENOG4107WP9 Histidine kinase CRN75_05230 ENOG4108SKK alpha helix protein CRN75_05235 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CRN75_05240 ENOG4105C4K Nad synthetase CRN75_05245 ENOG4108YZA Nitrogen regulatory protein pii CRN75_05250 ENOG4106M0N transport system permease protein CRN75_05255 ENOG4105MUZ Protein of unknown function DUF2620 CRN75_05260 ENOG41080QX K07048 phosphotriesterase-related protein CRN75_05265 ENOG4108626 Racemase CRN75_05270 ENOG4105RMW regulation of transcription, DNA-dependent CRN75_05275 ENOG4108M21 CRN75_05280 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CRN75_05285 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CRN75_05290 ENOG4105D8G Major Facilitator superfamily CRN75_05295 ENOG4108MN2 Stationary phase inducible protein CsiE CRN75_05300 ENOG41065CD Exported protein CRN75_05305 ENOG4105D7X high-affinity nickel-transporter CRN75_05315 ENOG4105CVS RNA methyltransferase TrmH family, group 1 CRN75_05320 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family CRN75_05325 ENOG4105C3J Cysteine desulfurase CRN75_05330 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins CRN75_05350 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB CRN75_05355 ENOG4108ZIT Ferredoxin, 2FE-2S CRN75_05360 ENOG4105WVQ Fe-S assembly protein IscX CRN75_05370 ENOG4105YYA enhanced serine sensitivity protein SseB CRN75_05375 ENOG4108MGN ATP-binding component of a transport system CRN75_05380 ENOG4105DN3 alpha-2-macroglobulin domain protein CRN75_05385 ENOG4108JQB penicillin-binding protein 1C CRN75_05410 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) CRN75_05420 ENOG4105CUT histidyl-tRNA synthetase CRN75_05425 ENOG4105N21 Membrane CRN75_05430 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CRN75_05435 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CRN75_05445 ENOG4105VPD cellular component movement CRN75_05450 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CRN75_05455 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CRN75_05460 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CRN75_05495 ENOG4105DWF phosphomethylpyrimidine kinase CRN75_05505 ENOG4108ZGU inhibitor of vertebrate lysozyme CRN75_05515 ENOG410804X Transcriptional regulator CRN75_05520 ENOG4105J92 DNA-binding transcriptional activator GutM CRN75_05525 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase CRN75_05530 ENOG4105VI0 Pts system, glucitol sorbitol-specific CRN75_05535 ENOG4105DZY Pts system, glucitol sorbitol-specific CRN75_05540 ENOG410787A Pts system, glucitol sorbitol-specific CRN75_05545 ENOG4107TE5 Lipid kinase CRN75_05555 ENOG4105CFP Peptidase U32 CRN75_05560 ENOG4105KWI UPF0339 protein CRN75_05565 ENOG4105E3W Two component transcriptional regulator (Winged helix family CRN75_05570 ENOG4105EB3 Histidine kinase CRN75_05575 ENOG4105BZS acriflavin resistance protein CRN75_05585 ENOG4105ENT Efflux transporter rnd family, mfp subunit CRN75_05590 ENOG4105R8A Heat shock protein CRN75_05595 ENOG4105BZU Histidine kinase CRN75_05600 ENOG4105CJW magnesium transporter CRN75_05610 ENOG4105C9X ppx gppa phosphatase CRN75_05615 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CRN75_05620 ENOG4105C8U phosphate abc transporter CRN75_05625 ENOG4105E2Z phosphate ABC transporter (Permease CRN75_05635 ENOG4108C80 FliB family CRN75_05645 ENOG4108MK9 spermidine N(1)-acetyltransferase CRN75_05650 ENOG4108V3E phosphoribosylglycinamide formyltransferase CRN75_05655 ENOG4105CXB phosphoribosylaminoimidazole synthetase CRN75_05660 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CRN75_05665 ENOG4105C2W permease CRN75_05670 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) CRN75_05675 ENOG4105K89 arsenate reductase CRN75_05680 ENOG4105ERG peptidase m48, ste24p CRN75_05685 ENOG4105C02 permease CRN75_05690 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CRN75_05695 ENOG4105RH4 Glycine cleavage system transcriptional repressor CRN75_05700 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CRN75_05705 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CRN75_05715 ENOG4105CGZ zinc metallopeptidase CRN75_05720 ENOG4108VMM UPF0756 membrane protein CRN75_05725 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) CRN75_05735 ENOG4106KED esterase YpfH CRN75_05740 ENOG4105XYK UPF0370 protein CRN75_05750 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CRN75_05755 ENOG4105KUZ arsenate reductase CRN75_05765 ENOG4105BZS acriflavin resistance protein CRN75_05775 ENOG4105WH1 Two component transcriptional regulator luxr family CRN75_05785 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase CRN75_05790 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CRN75_05795 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) CRN75_05800 ENOG4105CUW cytochrome C-TYPE protein CRN75_05805 ENOG4107VIJ nudix hydrolase CRN75_05810 ENOG4105C6K Malic enzyme CRN75_05815 ENOG4108UPT UPF0178 protein CRN75_05820 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) CRN75_05825 ENOG4108R6G acetyltransferase CRN75_05830 ENOG4105H4F exported protein CRN75_05835 ENOG4105E7K (LipO)protein CRN75_05840 ENOG4105EZR dyp-type peroxidase family protein CRN75_05860 ENOG4108R66 Conserved Protein CRN75_05870 ENOG4105QEK Transcriptional regulator CRN75_05885 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein CRN75_05890 ENOG4108I5D sulfate abc transporter CRN75_05895 ENOG4105ECW sulfate abc transporter CRN75_05905 ENOG4105C6T cysteine synthase CRN75_05915 ENOG4105DJY efflux transporter, rnd family, mfp subunit CRN75_05920 ENOG4105E3W Two component transcriptional regulator (Winged helix family CRN75_05925 ENOG4105E0F Histidine kinase CRN75_05930 ENOG4105C5Y PTS System CRN75_05940 ENOG4105KZ7 phosphocarrier protein hpr CRN75_05945 ENOG4105C6T cysteine synthase CRN75_05950 ENOG4105EXN Sulfate transport protein CysZ CRN75_05960 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CRN75_05965 ENOG4105VRT cytoplasmic protein CRN75_05995 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CRN75_06020 ENOG4105CK2 sodium dicarboxylate symporter CRN75_06040 ENOG4105DJI Methylaspartate mutase, E subunit CRN75_06050 ENOG4107WFU Glutamate mutase subunit sigma CRN75_06055 ENOG4105JZC GHMP kinase CRN75_06060 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CRN75_06065 ENOG41090KR LysR family transcriptional Regulator CRN75_06070 ENOG4107GFK fumarate CRN75_06075 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CRN75_06080 ENOG4105D9N nucleoside CRN75_06090 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CRN75_06100 ENOG4105CPC Aldo Keto reductase CRN75_06105 ENOG4105C5Q Transcriptional regulator CRN75_06115 ENOG4105CHC glucokinase (EC 2.7.1.2) CRN75_06120 ENOG4105FCD Major Facilitator CRN75_06125 ENOG4105DY9 regulatoR CRN75_06130 ENOG4108HRK Histidine kinase CRN75_06135 ENOG41072TH Protein of unknown function (DUF1479) CRN75_06145 ENOG4105CHM Aminotransferase CRN75_06150 ENOG4108VKM cytochrome b561 CRN75_06160 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin CRN75_06170 ENOG4108NEM leader-binding protein dmsD CRN75_06175 ENOG4107KGK dmso reductase anchor subunit CRN75_06180 ENOG4105QAX Iron-sulfur CRN75_06185 ENOG4107QY8 reductase CRN75_06200 ENOG4105CS2 ec 3.2.1.21 CRN75_06205 ENOG4105TW1 Carbohydrate-selective porin OprB CRN75_06215 ENOG4105E82 cytochrome subunit of dehydrogenase CRN75_06220 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CRN75_06235 ENOG4105CVE Lytic murein transglycosylase CRN75_06240 ENOG4105CUB amino acid CRN75_06265 ENOG4105DHJ ABC, transporter CRN75_06280 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CRN75_06285 ENOG4105CEM UPF0597 protein CRN75_06290 ENOG4105C28 cystathionine CRN75_06300 ENOG4105DS1 cytochrome b561 CRN75_06305 ENOG4108YYC ycei family CRN75_06310 ENOG4105DDV Transcriptional regulator (LacI family CRN75_06320 ENOG4106KR7 LysR family Transcriptional regulator CRN75_06330 ENOG4105C5Y PTS System CRN75_06335 ENOG4105CS2 ec 3.2.1.21 CRN75_06345 ENOG4105NTW Transcriptional regulator CRN75_06350 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CRN75_06370 ENOG4105S64 Formate nitrite transporter CRN75_06380 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) CRN75_06385 ENOG41060IM Heme exporter protein CRN75_06390 ENOG4105X3C heme exporter protein CRN75_06395 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) CRN75_06400 ENOG4105DA4 cytochrome c-type biogenesis protein CRN75_06405 ENOG4107QX9 Thiol disulfide interChange protein CRN75_06410 ENOG4105KWW Biogenesis protein CRN75_06415 ENOG4105KWW Biogenesis protein CRN75_06420 ENOG410903C (LipO)protein CRN75_06425 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation CRN75_06430 ENOG4105KZW UPF0381 protein CRN75_06435 ENOG4105CHU acetyl-coa acetyltransferase CRN75_06440 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CRN75_06450 ENOG4108BY2 phosphohistidine phosphatase CRN75_06455 ENOG4108DG9 Smr protein MutS2 CRN75_06460 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) CRN75_06465 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CRN75_06470 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) CRN75_06475 ENOG4105EJ9 Membrane CRN75_06480 ENOG4108BPE -transporting atpase CRN75_06485 ENOG4105MH2 YfcL protein CRN75_06490 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) CRN75_06495 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CRN75_06500 ENOG4105BZU Histidine kinase CRN75_06515 ENOG4105VCP PTS System CRN75_06520 ENOG4105CS2 ec 3.2.1.21 CRN75_06525 ENOG4105CK1 PTS System CRN75_06540 ENOG4105D6F Phosphatase CRN75_06545 ENOG4105F4P )-transporter CRN75_06550 ENOG4106WZ1 flagella biosynthesis regulator CRN75_06560 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CRN75_06570 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CRN75_06575 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CRN75_06585 ENOG410631K Membrane CRN75_06600 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CRN75_06610 ENOG4105DQR SNARE associated Golgi CRN75_06615 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CRN75_06620 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CRN75_06625 ENOG4108S3P Sporulation domain protein CRN75_06630 ENOG4105E96 Colicin v production protein CRN75_06635 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CRN75_06640 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CRN75_06645 ENOG4105E89 ABC transporter CRN75_06650 ENOG4105DSP amino acid AbC transporter CRN75_06655 ENOG4106YG3 ABC transporter CRN75_06660 ENOG4108JEH abc transporter atp-binding protein CRN75_06670 ENOG4105ECP epimerase CRN75_06680 ENOG4108RE9 Phosphodiesterase CRN75_06685 ENOG4105PTV Nudix Hydrolase CRN75_06690 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC CRN75_06700 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia CRN75_06705 ENOG4107P2S Transcriptional regulator CRN75_06710 ENOG4105C6K Malic enzyme CRN75_06725 ENOG4105PQ6 UPF0208 membrane protein CRN75_06730 ENOG4105XWI UPF0304 protein CRN75_06735 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 CRN75_06745 ENOG4107QWE )-transporter CRN75_06750 ENOG4105DK2 UPF0207 protein CRN75_06760 ENOG4105CHM Aminotransferase CRN75_06765 ENOG4107NQ8 LysR family Transcriptional regulator CRN75_06770 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CRN75_06775 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CRN75_06780 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CRN75_06785 ENOG4105GKE subunit e CRN75_06790 ENOG4107QIZ NADH dehydrogenase CRN75_06795 ENOG4108IEH NADH dehydrogenase subunit g CRN75_06800 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CRN75_06805 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CRN75_06810 ENOG4107UFS subunit j CRN75_06815 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CRN75_06820 ENOG4105D65 subunit l CRN75_06825 ENOG4105C8S subunit m CRN75_06830 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CRN75_06840 ENOG4108UQ5 membrane protein YcdZ CRN75_06845 ENOG4108R66 Conserved Protein CRN75_06850 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CRN75_06855 ENOG4105CHR reductase CRN75_06860 ENOG4105K2J Transcriptional regulator CRN75_06865 ENOG4105C5I Dehydrogenase CRN75_06875 ENOG41090KN UPF0303 protein CRN75_06880 ENOG4105C01 Dihydroxy-acid dehydratase CRN75_06885 ENOG4105TNS Conserved Protein CRN75_06890 ENOG4105E4F Isochorismate synthase CRN75_06895 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CRN75_06900 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CRN75_06905 ENOG4108IPT Naphthoate synthase CRN75_06910 ENOG4105DNI Converts SHCHC to OSB (By similarity) CRN75_06915 ENOG4105CEY Amp-dependent synthetase and ligase CRN75_06930 ENOG4105CH6 catalase CRN75_06935 ENOG4108UII YfaZ family CRN75_06940 ENOG4105E0U tyrosine-specific transport protein CRN75_06950 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) CRN75_06955 ENOG4105XPH Ferredoxin CRN75_06960 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CRN75_06965 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CRN75_06970 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CRN75_06975 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CRN75_06980 ENOG4105BZU Histidine kinase CRN75_06985 ENOG41068CG regulatoR CRN75_06990 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC CRN75_06995 ENOG4106UW1 Major Facilitator superfamily CRN75_07020 ENOG4107R6D beta-lactam binding protein AmpH CRN75_07025 ENOG4105CT4 transporter CRN75_07035 ENOG4105C8Q Methyl-accepting chemotaxis CRN75_07040 ENOG4105Y50 Virulence Protein CRN75_07050 ENOG4105HRS Antitermination protein CRN75_07060 ENOG4105KUS lysozyme CRN75_07080 ENOG4105TKZ Tail Sheath CRN75_07125 ENOG4108T86 baseplate J family protein CRN75_07150 ENOG4108C33 Resolvase CRN75_07155 ENOG4108Q3X Transcriptional regulator CRN75_07160 ENOG4105C5Y PTS System CRN75_07165 ENOG4105CS2 ec 3.2.1.21 CRN75_07180 ENOG4105E68 Sulfatase CRN75_07185 ENOG4105PAN UPF0352 protein CRN75_07190 ENOG4106V8H Nucleoid-associated protein CRN75_07200 ENOG4105CFI type iii restriction protein res subunit CRN75_07205 ENOG4105I08 Pseudouridine synthase CRN75_07210 ENOG4105C2C drug resistance transporter, Bcr CflA CRN75_07220 ENOG4105HG6 CRN75_07225 ENOG4108JQ5 ABC transporter CRN75_07230 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component CRN75_07235 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component CRN75_07240 ENOG4105E43 Extracellular solute-binding protein, family 5 CRN75_07245 ENOG4105CXC rtn protein CRN75_07255 ENOG4107TT5 NLP P60 protein CRN75_07260 ENOG41076MN Phosphoesterase, PA-phosphatase related CRN75_07265 ENOG4105CKI cobalamin synthesis protein CRN75_07275 ENOG4107YCY Transcriptional regulator CRN75_07280 ENOG4105DEI Mannitol dehydrogenase CRN75_07285 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CRN75_07290 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CRN75_07300 ENOG4105KRS Proteinase inhibitor CRN75_07305 ENOG4107QY8 reductase CRN75_07310 ENOG4105CUW cytochrome C-TYPE protein CRN75_07320 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CRN75_07325 ENOG4105DE4 1-phosphofructokinase CRN75_07330 ENOG4105DM4 PTS System CRN75_07335 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CRN75_07340 ENOG4105HMI Membrane CRN75_07350 ENOG4105DUM transcriptional regulator, lysR family CRN75_07355 ENOG4108IQI permease CRN75_07365 ENOG4105D05 Receptor CRN75_07370 ENOG4108TGY Glutathione S-transferase CRN75_07385 ENOG4105D01 (LipO)protein CRN75_07395 ENOG4108UMI ABC transporter, permease CRN75_07410 ENOG4105C28 cystathionine CRN75_07420 ENOG4105DZ1 carboxypeptidase CRN75_07430 ENOG4105EJQ L-serine dehydratase CRN75_07435 ENOG4105C44 Serine transporter CRN75_07440 ENOG4107FB0 transcriptional regulator DeoR family CRN75_07445 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CRN75_07450 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CRN75_07460 ENOG4105D0C transport protein CRN75_07465 ENOG41090BQ Glutaredoxin CRN75_07470 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress CRN75_07475 ENOG4108RMJ sensory transduction regulator CRN75_07480 ENOG4107RUE extracellular solute-binding protein family 1 CRN75_07485 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CRN75_07490 ENOG4105F38 ABC transporter, permease CRN75_07495 ENOG4105D38 putrescine abc transporter CRN75_07500 ENOG4105RBQ inner membrane protein ybjO CRN75_07505 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) CRN75_07510 ENOG4106TNF Periplasmic binding protein CRN75_07520 ENOG4105DMR ABC, transporter CRN75_07525 ENOG4105GBT ABC transporter CRN75_07530 ENOG4106PMH Extracellular solute-binding protein family 3 CRN75_07535 ENOG4105E5Z arginine transporter ATP-binding subunit CRN75_07540 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) CRN75_07545 ENOG41064MM (LipO)protein CRN75_07555 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase CRN75_07560 ENOG4105CGD Nad-dependent epimerase dehydratase CRN75_07565 ENOG4105C5W Aldolase CRN75_07570 ENOG4105C7K acetolactate synthase CRN75_07575 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CRN75_07580 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CRN75_07585 ENOG4105DWU Membrane CRN75_07590 ENOG4105CPB ATP-dependent endonuclease of the OLD family CRN75_07595 ENOG4108MJ5 VirK protein CRN75_07600 ENOG4105DJY efflux transporter, rnd family, mfp subunit CRN75_07610 ENOG4105VEQ Cold shock protein CRN75_07615 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CRN75_07620 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CRN75_07625 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CRN75_07630 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) CRN75_07635 ENOG4108JJ8 (ABC) transporter CRN75_07640 ENOG4108JJ9 ABC, transporter CRN75_07645 ENOG4105C3M thioredoxin reductase CRN75_07650 ENOG4105EW9 transcriptional regulator AsnC family CRN75_07655 ENOG4105CNU cell division protein FtsK CRN75_07660 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) CRN75_07665 ENOG4105D1H recombination factor protein RarA CRN75_07675 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CRN75_07680 ENOG4108ISG Major Facilitator CRN75_07685 ENOG4105F1A Pyruvate formate-lyase CRN75_07690 ENOG4105C6N Formate acetyltransferase CRN75_07695 ENOG4105TMB Formate nitrite transporter CRN75_07700 ENOG4105DDY UPF0142 protein ycaO CRN75_07705 ENOG4105HDK L-asparaginase CRN75_07710 ENOG4107VMU Membrane CRN75_07715 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CRN75_07720 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CRN75_07725 ENOG4105CAT Cytidine monophosphate kinase CRN75_07730 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CRN75_07740 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 CRN75_07750 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) CRN75_07755 ENOG4105E32 cytoplasmic protein CRN75_07760 ENOG4105VEQ Cold shock protein CRN75_07765 ENOG4105VEQ Cold shock protein CRN75_07770 ENOG4105W49 UPF0434 protein CRN75_07780 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups CRN75_07785 ENOG4107S90 membrAne CRN75_07790 ENOG4106371 Methyltransferase CRN75_07795 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) CRN75_07800 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) CRN75_07805 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) CRN75_07810 ENOG4105DIT ErfK YbiS YcfS YnhG family protein CRN75_07815 ENOG4105EAQ (twin-arginine translocation) pathway signal CRN75_07820 ENOG4105C5X domain protein CRN75_07825 ENOG4105BZU Histidine kinase CRN75_07830 ENOG4105CGF Aromatic amino acid aminotransferase CRN75_07840 ENOG4105C5S asparaginyl-tRNA synthetase CRN75_07845 ENOG4107RH7 Nicotinate phosphoribosyltransferase CRN75_07850 ENOG4105CD8 aminopeptidase N CRN75_07855 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CRN75_07860 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) CRN75_07865 ENOG4105QVC MOSC domain-containing protein CRN75_07870 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CRN75_07875 ENOG4105C5H ABC transporter CRN75_07885 ENOG4105DY2 Paraquat-inducible protein b CRN75_07890 ENOG4108Q2G (LipO)protein CRN75_07900 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) CRN75_07905 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CRN75_07915 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) CRN75_07920 ENOG4105DAN ATP-dependent protease CRN75_07925 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) CRN75_07930 ENOG4105UYK outer membrane protein a CRN75_07935 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) CRN75_07940 ENOG4108RZ1 DNA transformation protein CRN75_07945 ENOG4105EM2 membrane CRN75_07950 ENOG410901E Membrane CRN75_07955 ENOG41088T4 Helicase IV CRN75_07960 ENOG4108Z5K methylglyoxal synthase CRN75_07970 ENOG4105K4P CoA-binding domain protein CRN75_07975 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) CRN75_07980 ENOG4105DR4 Methyltransferase CRN75_07985 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 CRN75_07990 ENOG4108Z0T Part of a sulfur-relay system (By similarity) CRN75_08000 ENOG4107R1I NAD-dependent malic enzyme CRN75_08005 ENOG4105CEE C4-dicarboxylate transporter CRN75_08010 ENOG4108Q3X Transcriptional regulator CRN75_08015 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase CRN75_08030 ENOG4105VJY transcriptional regulator CRN75_08035 ENOG4107YC3 synthase CRN75_08045 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase CRN75_08050 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) CRN75_08065 ENOG4105DJ9 glucan biosynthesis protein CRN75_08070 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) CRN75_08075 ENOG4105NAC (LipO)protein CRN75_08085 ENOG4105DUX Transporter CRN75_08090 ENOG4105C6X Major Facilitator CRN75_08095 ENOG4108VGI doxx family CRN75_08100 ENOG4105D1S lipid A biosynthesis CRN75_08105 ENOG4108ZXC Two component transcriptional regulator, luxr family CRN75_08110 ENOG4106AFQ Histidine kinase CRN75_08115 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CRN75_08120 ENOG4106WHD Tetrathionate reductase CRN75_08125 ENOG4105DB1 molybdopterin oxidoreductase CRN75_08145 ENOG4105DSF transport protein CRN75_08165 ENOG4105PVA Biofilm formation regulatory protein BssS CRN75_08175 ENOG4105EKE dihydroorotase CRN75_08180 ENOG41067V3 Antibiotic biosynthesis monooxygenase CRN75_08185 ENOG4107QQB Ribonuclease E CRN75_08190 ENOG4105EI2 Pseudouridine synthase CRN75_08200 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein CRN75_08205 ENOG4105VGS 50s ribosomal protein l32 CRN75_08210 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CRN75_08220 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CRN75_08225 ENOG4105CHR reductase CRN75_08235 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CRN75_08240 ENOG4105YAZ 4-amino-4-deoxychorismate lyase CRN75_08245 ENOG4105HHA aminodeoxychorismate lyase CRN75_08250 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CRN75_08255 ENOG4107QRG dna polymerase iii CRN75_08260 ENOG4105F8V Hydrolase, tatD family CRN75_08265 ENOG4105CI1 PTS System CRN75_08275 ENOG4105F9E Shikimate 5-dehydrogenase CRN75_08280 ENOG4105K59 histidine triad (HIT) protein CRN75_08285 ENOG41090DQ Lipoprotein CRN75_08290 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) CRN75_08295 ENOG4108RUM thiamine kinase CRN75_08300 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) CRN75_08305 ENOG4105D0Y UPF0227 protein CRN75_08310 ENOG4105CEP NADH dehydrogenase CRN75_08315 ENOG4107MBR 17 kDa surface antigen CRN75_08320 ENOG4108JA2 transcriptioN-repair coupling factor CRN75_08325 ENOG4105D60 lipoprotein releasing system transmembrane protein CRN75_08335 ENOG4105D60 lipoprotein releasing system transmembrane protein CRN75_08340 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) CRN75_08345 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CRN75_08355 ENOG4105EZE Cupin 4 family protein CRN75_08365 ENOG4105XJC Two component transcriptional regulator (Winged helix family CRN75_08375 ENOG4107QTF adenylosuccinate lyase CRN75_08380 ENOG41075W9 High frequency lysogenization protein HflD homolog CRN75_08385 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CRN75_08395 ENOG4108R99 pseudouridine synthase CRN75_08400 ENOG4108HMX isocitrate dehydrogenase (NADP) CRN75_08415 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) CRN75_08420 ENOG4108HKT sucrose-6-phosphate hydrolase CRN75_08425 ENOG4106NDP Transcriptional regulator CRN75_08435 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor CRN75_08445 ENOG4108IQK o-acetylhomoserine CRN75_08450 ENOG4105ECR NmrA family CRN75_08455 ENOG4105KVH Transcriptional regulator CRN75_08470 ENOG4105DWP Membrane CRN75_08480 ENOG4105VTN Protein of unknown function (DUF1311) CRN75_08485 ENOG4105XXV Acid-resistance protein CRN75_08500 ENOG4105BZ1 (ABC) transporter CRN75_08510 ENOG4105D5Q Arginine ornithine antiporter CRN75_08525 ENOG4105N4N Protein of unknown function (DUF2766) CRN75_08530 ENOG4105TIK CRN75_08540 ENOG41064PC CRN75_08555 ENOG4105C85 amino acid CRN75_08560 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) CRN75_08565 ENOG410610J Protein of unknown function (DUF2627) CRN75_08570 ENOG4105VEQ Cold shock protein CRN75_08575 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CRN75_08585 ENOG4105DHI Methyltransferase CRN75_08595 ENOG4105BZU Histidine kinase CRN75_08605 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) CRN75_08615 ENOG4105F3R pts system mannose fructose sorbose family iid CRN75_08620 ENOG4105ETZ PTS System CRN75_08625 ENOG4108EQA pts system CRN75_08630 ENOG4105EE5 Membrane protein terC CRN75_08635 ENOG4105EJQ L-serine dehydratase CRN75_08640 ENOG4105P8F nudix hydrolase CRN75_08655 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CRN75_08660 ENOG4105C1J atp-dependent rna helicase CRN75_08665 ENOG4105X2V dna damage-inducible protein CRN75_08670 ENOG4105N5Z UPF0267 protein CRN75_08680 ENOG4105CUG Oligopeptidase b CRN75_08685 ENOG4105UMD exodeoxyribonuclease X CRN75_08695 ENOG4105MPK DNA polymerase III subunit theta CRN75_08700 ENOG41090A1 ferritin CRN75_08705 ENOG4105FXM Copper resistance protein CRN75_08710 ENOG4108PNC copper resistance CRN75_08715 ENOG4105NKT exported protein CRN75_08720 ENOG4108I1J Integrase CRN75_08805 ENOG4105RWQ Protein of unknown function (DUF1364) CRN75_08810 ENOG4105HRS Antitermination protein CRN75_08815 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CRN75_08860 ENOG4108ES9 ParB domain protein nuclease CRN75_08895 ENOG4107ZQ5 Phage-associated protein, HI1409 family CRN75_08905 ENOG41090AG Bacteriophage protein CRN75_09030 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CRN75_09035 ENOG4107RRE RNA-directed DNA polymerase CRN75_09075 ENOG4106050 phage regulatory protein, rha family CRN75_09105 ENOG41067SE Tetr family transcriptional regulator CRN75_09110 ENOG4105C26 Dehydrogenase CRN75_09170 ENOG4107ZHV Transcriptional regulator CRN75_09195 ENOG4105E2V Glycosyltransferase 36 CRN75_09215 ENOG4107Z1W Fructose transport system kinase CRN75_09220 ENOG4108R4K DNA-binding, transcriptional regulator CRN75_09225 ENOG4108Q8A Fructose-1,6-bisphosphatase CRN75_09230 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein CRN75_09235 ENOG4105CTS PTS system mannitol-specific CRN75_09240 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia CRN75_09260 ENOG4108VYJ response regulator receiver protein CRN75_09280 ENOG4105BZU Histidine kinase CRN75_09285 ENOG4105BZU Histidine kinase CRN75_09305 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit CRN75_09310 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CRN75_09315 ENOG4105DVI reductase, NrfD CRN75_09320 ENOG4105DA4 cytochrome c-type biogenesis protein CRN75_09325 ENOG4107QX9 Thiol disulfide interChange protein CRN75_09335 ENOG4108W0S formate-dependent nitrite reductase complex CRN75_09350 ENOG4105D7K pfkb domain protein CRN75_09355 ENOG4106KNT transcriptional regulator CRN75_09360 ENOG4105CNN ABC, transporter CRN75_09365 ENOG4105C2J ABC transporter CRN75_09375 ENOG4105C93 Xylose Isomerase CRN75_09440 ENOG4107SET aldo keto reductase CRN75_09455 ENOG4105DFD Na H antiporter CRN75_09465 ENOG4108RW8 Universal stress protein F CRN75_09475 ENOG4108K5P (LipO)protein CRN75_09485 ENOG4105D2N Aldolase CRN75_09490 ENOG4105E70 isomerase CRN75_09495 ENOG4105CE4 GlcNAc 6-P deacetylase CRN75_09500 ENOG4108YTN IIa component CRN75_09505 ENOG4105F3R pts system mannose fructose sorbose family iid CRN75_09515 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB CRN75_09520 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of CRN75_09530 ENOG4105E98 transcriptional regulator DeoR family CRN75_09535 ENOG4105SUA Ydil protein CRN75_09540 ENOG4105EMV Major Facilitator CRN75_09545 ENOG4105DND Transcriptional regulator CRN75_09550 ENOG4105EMV Major Facilitator CRN75_09565 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) CRN75_09570 ENOG4105C1G acyl-Coa dehydrogenase CRN75_09575 ENOG4105W4W Transcriptional regulator CRN75_09580 ENOG4105CV7 Electron transfer flavoprotein CRN75_09585 ENOG4105C10 Electron transfer flavoprotein CRN75_09590 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase CRN75_09595 ENOG41090P5 ferredoxin-like protein CRN75_09600 ENOG4105CEY Amp-dependent synthetase and ligase CRN75_09605 ENOG4105DJ2 Major Facilitator Superfamily CRN75_09615 ENOG4107B2H carbonic anhydrase CRN75_09620 ENOG4105DND Transcriptional regulator CRN75_09625 ENOG4105CKT filamentous hemagglutinin CRN75_09655 ENOG4105CKT filamentous hemagglutinin CRN75_09700 ENOG4105CKT filamentous hemagglutinin CRN75_09730 ENOG4105D5K Hemolysin activator protein CRN75_09780 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family CRN75_09785 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CRN75_09795 ENOG4108IG5 Transcriptional regulator CRN75_09820 ENOG4105F9N Major Facilitator Superfamily CRN75_09825 ENOG4107SET aldo keto reductase CRN75_09830 ENOG4105HFT AraC family transcriptional regulator CRN75_09835 ENOG4105ENT Efflux transporter rnd family, mfp subunit CRN75_09840 ENOG4105BZS acriflavin resistance protein CRN75_09850 ENOG4105EQ2 LysR family Transcriptional regulator CRN75_09860 ENOG4105GR3 Histidine kinase CRN75_09885 ENOG4105CV8 reductase CRN75_09910 ENOG4105D5G Transposase CRN75_09915 ENOG4105DFP Integrase CRN75_09920 ENOG4105C3G gtp-binding protein CRN75_09930 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CRN75_09935 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria CRN75_09940 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CRN75_09950 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) CRN75_09955 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CRN75_09960 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CRN75_09965 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CRN75_09970 ENOG4108YY7 Invasion gene expression up-regulator SirB CRN75_09975 ENOG41063JG Transcriptional regulator CRN75_09985 ENOG4105CHH sulfate transporter CRN75_09990 ENOG4105BZU Histidine kinase CRN75_10010 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase CRN75_10020 ENOG4107XHZ cytoplasmic chaperone TorD family protein CRN75_10025 ENOG4105F3T (LipO)protein CRN75_10030 ENOG4105EV4 Multidrug resistance protein mdtH CRN75_10035 ENOG4105D9U N-acetyltransferase CRN75_10045 ENOG4105EP9 oxidoreductase CRN75_10050 ENOG4105CJR Integral membrane protein (MviN CRN75_10055 ENOG4105C75 arginyL-tRNA synthetase CRN75_10060 ENOG4106ZCM YecM protein CRN75_10065 ENOG4106N3A copper homeostasis protein cutc CRN75_10070 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) CRN75_10080 ENOG4105WJG Glutathione CRN75_10085 ENOG41081XQ Conserved Protein CRN75_10090 ENOG4105D3W isochorismatase CRN75_10105 ENOG4105C9M aspartyl-trna synthetase CRN75_10110 ENOG4108TIT dATP pyrophosphohydrolase CRN75_10115 ENOG4105CDY transcriptional regulatory protein CRN75_10125 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CRN75_10130 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CRN75_10135 ENOG4105DUX Transporter CRN75_10140 ENOG4105FAV ABC, transporter CRN75_10145 ENOG4105FDK ABC transporter CRN75_10150 ENOG4105NXV High-affinity zinc uptake system protein CRN75_10155 ENOG4105DR5 peptidase CRN75_10160 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase CRN75_10165 ENOG4105CA9 Pyruvate kinase CRN75_10170 ENOG4106KNT transcriptional regulator CRN75_10175 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CRN75_10180 ENOG4108UHU Aldolase CRN75_10185 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) CRN75_10195 ENOG4105M4H endoribonuclease L-psp CRN75_10200 ENOG4105DVT helicase CRN75_10205 ENOG41072GX Peptidase M22 Glycoprotease CRN75_10210 ENOG4105Y4Z Outer Membrane Lipoprotein CRN75_10215 ENOG4105CEY Amp-dependent synthetase and ligase CRN75_10220 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) CRN75_10225 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) CRN75_10230 ENOG4107QMS site-determining protein CRN75_10235 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CRN75_10245 ENOG4105VNG YcgL domain-containing protein CRN75_10250 ENOG4105CVE Lytic murein transglycosylase CRN75_10255 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase CRN75_10260 ENOG4108ZZ3 UPF0260 protein CRN75_10270 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CRN75_10275 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) CRN75_10280 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CRN75_10290 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) CRN75_10295 ENOG4105ED1 spovr family CRN75_10300 ENOG4105MWK D-amino acid dehydrogenase, small subunit CRN75_10305 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CRN75_10310 ENOG4105CNH Multidrug resistance protein MdtL CRN75_10315 ENOG4105BZU Histidine kinase CRN75_10320 ENOG4105EUB pirin domain protein CRN75_10325 ENOG4105HEI LysR family (Transcriptional regulator CRN75_10335 ENOG4106AKX UPF0229 protein CRN75_10340 ENOG4105CYN Serine protein kinase CRN75_10350 ENOG4105GNX MltA-interacting MipA family protein CRN75_10355 ENOG4105DSB aldose 1-epimerase CRN75_10370 ENOG4105VUT cytoplasmic protein CRN75_10375 ENOG4108RWI nicotinamidase CRN75_10380 ENOG4105HDK L-asparaginase CRN75_10385 ENOG4105D07 Signal peptide peptidase, SppA CRN75_10390 ENOG41069NU Nitroreductase CRN75_10400 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CRN75_10405 ENOG4105MTM Protein of unknown function (DUF1496) CRN75_10410 ENOG4105M6F mutator MutT protein CRN75_10415 ENOG4105CGK Exodeoxyribonuclease III CRN75_10420 ENOG4105SKE transcriptional Regulator LysR family CRN75_10440 ENOG4105CIY formyltetrahydrofolate deformylase CRN75_10445 ENOG4105K5B UPF0225 protein CRN75_10455 ENOG4105D78 K07001 NTE family protein CRN75_10460 ENOG4105I93 response regulator CRN75_10465 ENOG4105C6Y Udp-glucose 6-dehydrogenase CRN75_10480 ENOG4107104 thymidine kinase CRN75_10485 ENOG4108EKI Dehydrogenase CRN75_10495 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CRN75_10500 ENOG4108J59 Extracellular solute-binding protein, family 5 CRN75_10505 ENOG4107QSI ABC, transporter CRN75_10510 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CRN75_10515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CRN75_10520 ENOG4105C3U ABC transporter CRN75_10525 ENOG4108JQ7 (ABC) transporter CRN75_10535 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CRN75_10545 ENOG4105CMB EAL domain-containing protein CRN75_10555 ENOG4105K9H YciI-like protein CRN75_10560 ENOG410822N TonB family CRN75_10565 ENOG4105NAU thioesterase Superfamily protein CRN75_10570 ENOG4107835 probably involved in intracellular septation (By similarity) CRN75_10580 ENOG4108S3I UPF0259 membrane protein CRN75_10585 ENOG4105PI0 Ferredoxin CRN75_10590 ENOG4105EIF outer membrane protein W CRN75_10600 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CRN75_10605 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CRN75_10610 ENOG4105DK0 Indole-3-glycerol phosphate synthase CRN75_10620 ENOG4105DDQ anthranilate synthase CRN75_10630 ENOG4105DB7 PHP domain protein CRN75_10635 ENOG4107RTD sua5 ycio yrdc ywlc family protein CRN75_10645 ENOG4108Q9V regulatoR CRN75_10655 ENOG4105TNG K13735 adhesin invasin CRN75_10670 ENOG4108WQH regulatoR CRN75_10700 ENOG4108C33 Resolvase CRN75_10740 ENOG4105FE9 pseudouridine synthase CRN75_10750 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CRN75_10755 ENOG4105UBK short-chain dehydrogenase reductase CRN75_10760 ENOG4105ERU peptidase CRN75_10765 ENOG4105RKX Protein of unknown function (DUF2498) CRN75_10775 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CRN75_10780 ENOG4107R11 Transcriptional regulator CRN75_10790 ENOG4107QM5 aconitate hydratase CRN75_10795 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) CRN75_10800 ENOG4105EYK Phosphatidylglycerophosphatase B CRN75_10805 ENOG4105Q4A inner membrane protein yciS CRN75_10810 ENOG4105CFV Tetratricopeptide repeat protein CRN75_10830 ENOG4108ZJT translation initiation factor, Sui1 CRN75_10840 ENOG41061RM osmotically inducible lipoprotein CRN75_10845 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase CRN75_10855 ENOG4105N2W Transcriptional regulator CRN75_10860 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CRN75_10865 ENOG4105VCD cytoplasmic protein CRN75_10870 ENOG4105D22 carbon starvation protein CRN75_10875 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) CRN75_10880 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit CRN75_10885 ENOG4105CSM endonuclease III CRN75_10895 ENOG4108UQQ Electron transport complex CRN75_10900 ENOG4105D6A Electron transport complex CRN75_10905 ENOG4105UEI Transcriptional Regulator AraC Family CRN75_10910 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CRN75_10920 ENOG4105DGN Electron transport complex CRN75_10925 ENOG4105M9B inner membrane protein ydgK CRN75_10930 ENOG4105CKU formyltetrahydrofolate synthetase CRN75_10935 ENOG4108JJA ABC, transporter CRN75_10940 ENOG4105C42 Type I secretion membrane fusion protein (HlyD CRN75_10950 ENOG4105CS2 ec 3.2.1.21 CRN75_10955 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CRN75_10970 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator CRN75_10980 ENOG4105CNN ABC, transporter CRN75_10990 ENOG4105D9R oxidoreductase CRN75_10995 ENOG4105DHU Bile acid CRN75_11000 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CRN75_11020 ENOG4105C87 Aminotransferase class I and II CRN75_11025 ENOG4105CI1 PTS System CRN75_11030 ENOG4107P2S Transcriptional regulator CRN75_11040 ENOG4107RSM transcriptional regulator CRN75_11045 ENOG4106J39 exported protein CRN75_11050 ENOG4105EIP mannose-6-phosphate isomerase CRN75_11055 ENOG4105C9Q fumarate hydratase class II CRN75_11060 ENOG4105DJV ribulose-phosphate 3-epimerase CRN75_11065 ENOG4108YZG isomerase CRN75_11075 ENOG4105NYY transcriptional regulator, RpiR CRN75_11080 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) CRN75_11095 ENOG4105D94 Major Facilitator Superfamily CRN75_11100 ENOG4106NZI LysR family Transcriptional regulator CRN75_11105 ENOG4105DAG ROK family CRN75_11110 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CRN75_11120 ENOG4105KBG Protein of unknown function (DUF1161) CRN75_11125 ENOG4105M5Q UPF0482 protein CRN75_11130 ENOG4105KK4 UPF0060 membrane protein CRN75_11140 ENOG4105EMU Dehydrogenase CRN75_11145 ENOG4105C0R drug resistance transporter emrb qaca subfamily CRN75_11150 ENOG4105TDT uncharacterized protein yahO CRN75_11155 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CRN75_11160 ENOG4108R6W Transcriptional regulator, ARAC family CRN75_11180 ENOG4105CYM Glutathione S-transferase CRN75_11190 ENOG4108RYR transcriptional regulator AsnC family CRN75_11200 ENOG4105DSP amino acid AbC transporter CRN75_11205 ENOG4105E89 ABC transporter CRN75_11210 ENOG4106V2I dimethylaminohydrolase CRN75_11215 ENOG4105CJ2 (LipO)protein CRN75_11220 ENOG4105FYV Amp nucleosidase CRN75_11240 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CRN75_11255 ENOG4105C7K acetolactate synthase CRN75_11260 ENOG4105M71 acetolactate synthase 1 regulatory subunit CRN75_11265 ENOG4105PAD Hydrolase CRN75_11275 ENOG4105ETT transcriptional Regulator, LysR family CRN75_11290 ENOG4105EDR glucose galactose transporter CRN75_11295 ENOG4108RVA ribokinase CRN75_11310 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) CRN75_11325 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CRN75_11330 ENOG4105DS0 Transcriptional regulator, Crp Fnr family CRN75_11335 ENOG4105Q9Y Universal stress protein CRN75_11340 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CRN75_11345 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CRN75_11350 ENOG4105C5D exported protein CRN75_11355 ENOG4105D5Q Arginine ornithine antiporter CRN75_11365 ENOG4107EXC regulatoR CRN75_11370 ENOG4105JJR Histidine kinase CRN75_11375 ENOG4105CTD carboxy-peptidase CRN75_11390 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap CRN75_11400 ENOG4105MRD Phage derived protein Gp49-like (DUF891) CRN75_11405 ENOG4105CQ7 ATP-dependent helicase CRN75_11410 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CRN75_11415 ENOG4105DKT Transcriptional regulator CRN75_11420 ENOG4105DEI Mannitol dehydrogenase CRN75_11425 ENOG4105CMG Carbohydrate kinase CRN75_11430 ENOG4105IE8 Alpha-ketoglutarate permease CRN75_11435 ENOG4105WXT Conserved Protein CRN75_11440 ENOG410689M (LipO)protein CRN75_11445 ENOG4107H52 Dicarboxylate transport CRN75_11450 ENOG4105C5I Dehydrogenase CRN75_11470 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) CRN75_11475 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C CRN75_11480 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) CRN75_11500 ENOG4107QSI ABC, transporter CRN75_11505 ENOG4105KXI murein peptide amidase A CRN75_11510 ENOG4107S8C mandelate racemase muconate lactonizing CRN75_11515 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CRN75_11535 ENOG4106K28 UPF0283 membrane protein CRN75_11540 ENOG4105CM6 amino acid regulated cytosolic protein CRN75_11550 ENOG4105FM1 phage shock protein C CRN75_11555 ENOG4105YYT phage shock protein B CRN75_11560 ENOG41087YS Phage shock protein A CRN75_11565 ENOG4105E51 psp operon transcriptional activator CRN75_11575 ENOG4108HIY periplasmic CRN75_11580 ENOG4108I5W peptide transport system, permease protein CRN75_11585 ENOG4108EU3 peptide transport system, permease CRN75_11590 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein CRN75_11595 ENOG4108JQ2 peptide transport system atp-binding protein CRN75_11600 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CRN75_11605 ENOG4105Q4T oxidoreductase CRN75_11610 ENOG4105DUM transcriptional regulator, lysR family CRN75_11615 ENOG4105DUX Transporter CRN75_11630 ENOG41069YE inner membrane protein yohC CRN75_11635 ENOG4108ZR5 Conserved Protein CRN75_11640 ENOG4108K3A Glutathione S-transferase CRN75_11655 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) CRN75_11660 ENOG410642K Lysozyme inhibitor CRN75_11665 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CRN75_11670 ENOG4108XTF Outer Membrane Lipoprotein CRN75_11675 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) CRN75_11685 ENOG4105Y49 secretion protein, HlyD family CRN75_11690 ENOG4105DSW Fusaric acid resistance protein CRN75_11695 ENOG4107RGM aldo keto reductase CRN75_11700 ENOG4105XZD Fe-S protein CRN75_11705 ENOG4105DIJ Phosphoethanolamine transferase CRN75_11710 ENOG4108WUH Transcriptional regulator, TetR family CRN75_11715 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CRN75_11720 ENOG4108UYE Lactoylglutathione lyase CRN75_11725 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) CRN75_11730 ENOG4105M2J Glutaredoxin CRN75_11740 ENOG4105K4H Nlp p60 protein CRN75_11745 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CRN75_11755 ENOG4105ETE Transcriptional regulator (LacI family CRN75_11760 ENOG4105F52 Transcriptional regulator CRN75_11765 ENOG4105CZQ inner membrane transport protein YdhC CRN75_11770 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CRN75_11775 ENOG4108R6K riboflavin synthase, subunit alpha CRN75_11780 ENOG4107QI1 Mate efflux family protein CRN75_11800 ENOG4105CA9 Pyruvate kinase CRN75_11805 ENOG4105KMX major outer membrane lipoprotein CRN75_11820 ENOG4108IND Tetr family transcriptional regulator CRN75_11825 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CRN75_11830 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CRN75_11840 ENOG4105JRK feS assembly protein SufD CRN75_11845 ENOG4105C3K feS assembly ATPase SufC CRN75_11850 ENOG4105DIW FeS assembly protein SUFB CRN75_11855 ENOG4108Z4V iron-sulfur cluster assembly CRN75_11860 ENOG4105KA0 thioesterase Superfamily protein CRN75_11865 ENOG4105CQB FAD linked oxidase domain protein CRN75_11870 ENOG4105IPI Membrane CRN75_11880 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CRN75_11890 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CRN75_11895 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CRN75_11900 ENOG4107F3C Hemin uptake protein CRN75_11905 ENOG4107ENK receptor CRN75_11910 ENOG4106QJH hemin transport protein CRN75_11915 ENOG4107R4I Periplasmic binding protein CRN75_11925 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) CRN75_11930 ENOG4108QBX (LipO)protein CRN75_11935 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CRN75_11940 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CRN75_11945 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) CRN75_11950 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) CRN75_11960 ENOG4105CKK Glycosyl transferase, family 2 CRN75_11965 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CRN75_11970 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) CRN75_11975 ENOG4108V06 Glutathione peroxidase CRN75_11980 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) CRN75_11990 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CRN75_12015 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CRN75_12020 ENOG4105C22 threonyL-tRNA synthetase CRN75_12025 ENOG41087WU CRN75_12030 ENOG4108UQV Membrane CRN75_12055 ENOG41082NP Multiple antibiotic resistance CRN75_12060 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division CRN75_12065 ENOG4105DSE periplasmic solute binding protein CRN75_12070 ENOG4105DIK (ABC) transporter CRN75_12075 ENOG4105CC5 ABC transporter CRN75_12080 ENOG4105CC5 ABC transporter CRN75_12085 ENOG4105FGM Fructosamine kinase CRN75_12090 ENOG4105D5P Methylmalonyl-coA mutase CRN75_12095 ENOG4105DJT lAO AO transport system ATPase CRN75_12100 ENOG4108M7F enoyl-CoA hydratase isomerase CRN75_12105 ENOG4105CYC Transferase CRN75_12110 ENOG4105DEQ transcriptional regulator CRN75_12115 ENOG4107PN8 YfeABCD locus regulator CRN75_12120 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 CRN75_12125 ENOG4105M5J Cupin 2, conserved barrel domain protein CRN75_12130 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) CRN75_12135 ENOG4105CHR reductase CRN75_12140 ENOG41061NF Pectate lyase CRN75_12145 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CRN75_12150 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CRN75_12160 ENOG4105WEM extracellular solute-binding protein CRN75_12165 ENOG4108PU9 oligogalacturonate-specific porin CRN75_12170 ENOG4107K5X Membrane-bound metal-dependent hydrolase CRN75_12175 ENOG4108ETY sodium dicarboxylate symporter CRN75_12180 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CRN75_12190 ENOG4105CAZ oligogalacturonide lyase CRN75_12195 ENOG4105C0R drug resistance transporter emrb qaca subfamily CRN75_12205 ENOG4105D0M Protease HtpX homolog CRN75_12210 ENOG4105CN1 protease CRN75_12220 ENOG4108ZGC gaf domain protein CRN75_12225 ENOG4105H2K paraquat-inducible protein a CRN75_12230 ENOG4105DY2 Paraquat-inducible protein b CRN75_12240 ENOG4105C0R drug resistance transporter emrb qaca subfamily CRN75_12280 ENOG4105WT8 Protein of unknown function (DUF1480) CRN75_12305 ENOG4108SHQ Glutathione S-transferase CRN75_12330 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CRN75_12340 ENOG4105KME endoribonuclease L-psp CRN75_12350 ENOG4105C6X Major Facilitator CRN75_12365 ENOG4108MEK Metal-binding protein YodA CRN75_12370 ENOG4108HWV )-transporter CRN75_12375 ENOG4105C2J ABC transporter CRN75_12385 ENOG41090B9 response to stress CRN75_12390 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CRN75_12395 ENOG4105CZE histidine utilization repressor CRN75_12400 ENOG4105CI2 imidazolone-5-propionate hydrolase CRN75_12415 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) CRN75_12420 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) CRN75_12430 ENOG4105F4X arginine CRN75_12435 ENOG4105C8Y Acetylornithine aminotransferase CRN75_12440 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CRN75_12450 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CRN75_12460 ENOG4105BZU Histidine kinase CRN75_12465 ENOG4107R11 Transcriptional regulator CRN75_12475 ENOG4105EWV Sodium calcium exchanger membrane region CRN75_12480 ENOG4105D5M phosphate starvation-inducible protein CRN75_12490 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD CRN75_12495 ENOG4105CND Glycosyl transferase, family 2 CRN75_12500 ENOG4107BJW polysaccharide deacetylase CRN75_12505 ENOG4108TUY outer membrane protein PgaA CRN75_12510 ENOG4105H1N peptidase, M24 CRN75_12515 ENOG4108819 ferric iron reductase CRN75_12520 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CRN75_12525 ENOG4105EXG Transcriptional regulator CRN75_12545 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CRN75_12555 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CRN75_12570 ENOG4107SJW iron permease, FTR1 CRN75_12585 ENOG4105CSV Glutaminase CRN75_12590 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CRN75_12595 ENOG4108MRH transcriptional regulatory protein CRN75_12605 ENOG4105C85 amino acid CRN75_12620 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase CRN75_12635 ENOG4106UW1 Major Facilitator superfamily CRN75_12640 ENOG4108HCJ Hydrolase CRN75_12645 ENOG4105FE9 pseudouridine synthase CRN75_12655 ENOG4105JAB phenazine biosynthesis protein, phzf family CRN75_12670 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CRN75_12720 ENOG4105DFE Dna adenine methylase CRN75_12725 ENOG4105VZ1 Replication Protein CRN75_12750 ENOG4105ED4 portal protein CRN75_12885 ENOG4105ZTC transcriptional activator, Ogr delta CRN75_12890 ENOG4105Y50 Virulence Protein CRN75_12955 ENOG4105E4C Lytic transglycosylase catalytic CRN75_13080 ENOG4105RWQ Protein of unknown function (DUF1364) CRN75_13125 ENOG4105CDU Replicative dna helicase CRN75_13200 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CRN75_13205 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CRN75_13210 ENOG4105WH1 Two component transcriptional regulator luxr family CRN75_13215 ENOG4105XVG cytoplasmic protein CRN75_13220 ENOG4105RA2 Membrane CRN75_13230 ENOG4105C8Q Methyl-accepting chemotaxis CRN75_13235 ENOG4105E5K Alpha-amylase CRN75_13250 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CRN75_13265 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CRN75_13305 ENOG4105VZ1 Replication Protein CRN75_13335 ENOG4105ED4 portal protein CRN75_13430 ENOG4105UZW Tail fiber assembly protein CRN75_13495 ENOG4108V1U phospholipid-binding protein CRN75_13500 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) CRN75_13510 ENOG4105CS1 NAD(P)H quinone oxidoreductase CRN75_13530 ENOG4105CK7 Sodium proline symporter CRN75_13535 ENOG4105C26 Dehydrogenase CRN75_13550 ENOG4105CDA abc transporter atp-binding protein CRN75_13555 ENOG4105E5Q amino acid AbC transporter CRN75_13560 ENOG4105EAB amino acid AbC transporter CRN75_13565 ENOG4105K6H D-cysteine desulfhydrase CRN75_13570 ENOG4108M9K flagella biosynthesis protein FliZ CRN75_13575 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CRN75_13580 ENOG4105I03 Flagellin CRN75_13585 ENOG4105DTS flagellar hook-associated CRN75_13590 ENOG4105MQ3 flagellar protein FliS CRN75_13595 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) CRN75_13605 ENOG4105DHT Metal Dependent Phosphohydrolase CRN75_13625 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CRN75_13630 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CRN75_13635 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CRN75_13640 ENOG41090PJ Flagellar assembly protein CRN75_13645 ENOG4108JIR Flagellum-specific ATP synthase CRN75_13650 ENOG4105GSA Flagellar export protein flij CRN75_13655 ENOG4105WF4 Flagellar hook-length control protein CRN75_13660 ENOG4107ZI8 flagellar basal body-associated protein flil CRN75_13665 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CRN75_13670 ENOG4105DD5 Flagellar motor switch protein CRN75_13680 ENOG4105CN7 Flagellar biosynthetic protein FliP CRN75_13685 ENOG4105VS8 Flagellar biosynthetic protein fliq CRN75_13690 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CRN75_13695 ENOG4105DTJ flagellar hook-associated protein CRN75_13700 ENOG4105E1Q flagellar hook-associated protein CRN75_13705 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CRN75_13720 ENOG4105CGA flagellar basal-body rod protein FlgG CRN75_13725 ENOG4108KPB Flagellar basal-body rod protein FlgF CRN75_13730 ENOG4105BZE flagellar hook protein, FlgE CRN75_13735 ENOG4105W00 Flagellar hook capping protein CRN75_13740 ENOG4108ZC9 flagellar basal-body rod protein flgc CRN75_13745 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CRN75_13750 ENOG4105CKS Flagella basal body P-ring formation protein flgA CRN75_13755 ENOG4105M9M anti-sigma28 factor FlgM CRN75_13760 ENOG4105QVD Flagella synthesis protein FlgN CRN75_13765 ENOG4105W13 flagellar protein CRN75_13770 ENOG4105D7B Flagellar biosynthesis protein flha CRN75_13775 ENOG4105D00 flagellar biosynthetic protein flhB CRN75_13780 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CRN75_13785 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) CRN75_13790 ENOG4108VYJ response regulator receiver protein CRN75_13800 ENOG4105BZU Histidine kinase CRN75_13805 ENOG4105C8Q Methyl-accepting chemotaxis CRN75_13810 ENOG4105C8Q Methyl-accepting chemotaxis CRN75_13815 ENOG4108V3W Chemotaxis protein, CheW CRN75_13820 ENOG4105CBS Chea signal transduction histidine kinase CRN75_13825 ENOG4105ER2 Ompa motb domain protein CRN75_13830 ENOG4107RD7 Flagellar Motor Protein, MotA CRN75_13835 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region CRN75_13840 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) CRN75_13845 ENOG4108VA4 Universal stress protein CRN75_13850 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CRN75_13855 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CRN75_13860 ENOG4105KT7 mgtC SapB transporter CRN75_13870 ENOG4105C8Q Methyl-accepting chemotaxis CRN75_13875 ENOG4105VZF DsrB protein CRN75_13880 ENOG4105VEQ Cold shock protein CRN75_13885 ENOG4105ETE Transcriptional regulator (LacI family CRN75_13890 ENOG4105CNT hydrolase family 2 CRN75_13905 ENOG4105GSJ Inner membrane protein ylaC CRN75_13910 ENOG4105J0Q Transcriptional regulator CRN75_13920 ENOG41061EV selenium-binding protein YdfZ CRN75_13925 ENOG4105D6F Phosphatase CRN75_13930 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CRN75_13935 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is CRN75_13940 ENOG4105CT4 transporter CRN75_13945 ENOG4105CT4 transporter CRN75_13950 ENOG4105CJQ hydrolase, family 31 CRN75_13960 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CRN75_13965 ENOG4105D2N Aldolase CRN75_13970 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CRN75_13975 ENOG4108MGF sugar kinase CRN75_13980 ENOG4105E98 transcriptional regulator DeoR family CRN75_13990 ENOG41077RS Phosphatase CRN75_13995 ENOG4105E8V Alpha Beta Hydrolase Fold protein CRN75_14005 ENOG4108HPI phosphatidate Cytidylyltransferase CRN75_14010 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase CRN75_14025 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) CRN75_14035 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CRN75_14045 ENOG4108V06 Glutathione peroxidase CRN75_14060 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein CRN75_14095 ENOG4107QVY Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CRN75_14115 ENOG4107RTG Major Facilitator superfamily CRN75_14120 ENOG4105ENX hydrolase CRN75_14125 ENOG4105EQ2 LysR family Transcriptional regulator CRN75_14130 ENOG4105DDV Transcriptional regulator (LacI family CRN75_14135 ENOG4105DKQ ROK family CRN75_14140 ENOG4105VCP PTS System CRN75_14145 ENOG4105CK1 PTS System CRN75_14150 ENOG4105VZJ PTS System CRN75_14155 ENOG4105CK1 PTS System CRN75_14160 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CRN75_14170 ENOG4105CS2 ec 3.2.1.21 CRN75_14175 ENOG4105EIP mannose-6-phosphate isomerase CRN75_14180 ENOG4105D3G Pseudouridine synthase CRN75_14185 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme CRN75_14195 ENOG4108TSE Transferase CRN75_14200 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CRN75_14210 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CRN75_14215 ENOG4107QPK )-transporter CRN75_14220 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase CRN75_14225 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase CRN75_14230 ENOG4105CHY citrate lyase, alpha CRN75_14235 ENOG4105CI0 Citrate lyase CRN75_14240 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) CRN75_14245 ENOG4105DUA (citrate (pro-3S)-lyase ligase CRN75_14250 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CRN75_14260 ENOG4108KX4 response regulator CRN75_14265 ENOG4105BZU Histidine kinase CRN75_14270 ENOG4105CXY transporter CRN75_14275 ENOG4105C4Y ABC transporter CRN75_14280 ENOG4107RCV ABC transporter, permease CRN75_14285 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CRN75_14295 ENOG4108Q9V regulatoR CRN75_14300 ENOG4105BZU Histidine kinase CRN75_14315 ENOG4105CW0 outer membrane usher protein CRN75_14325 ENOG4108MQF Chaperone CRN75_14340 ENOG4105ECQ AraC Family Transcriptional Regulator CRN75_14350 ENOG4107R88 Chemotaxis protein (CheV) CRN75_14355 ENOG4105E98 transcriptional regulator DeoR family CRN75_14360 ENOG410667J hydrolase CRN75_14375 ENOG4105UQX Mate efflux family protein CRN75_14380 ENOG4105CDH Citrulline--aspartate ligase CRN75_14385 ENOG4105EAA nucleoside CRN75_14390 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) CRN75_14400 ENOG4105CN8 Transcriptional regulator CRN75_14405 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CRN75_14410 ENOG4108TGR phosphatase CRN75_14415 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) CRN75_14420 ENOG4108YZT Adenosylcobinamide kinase CRN75_14425 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CRN75_14435 ENOG4108V4M Cobalt abc transporter CRN75_14440 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CRN75_14445 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CRN75_14450 ENOG4105DVK Precorrin-2 c20-methyltransferase CRN75_14455 ENOG4107PPM cobalt chelatase CRN75_14460 ENOG4105QUC reductase CRN75_14465 ENOG4105E4R Precorrin-3B C17-methyltransferase CRN75_14470 ENOG4108P62 biosynthesis protein (CbiG) CRN75_14475 ENOG4105CIA precorrin-4 C(11)-methyltransferase CRN75_14480 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase CRN75_14485 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase CRN75_14490 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) CRN75_14495 ENOG41081F0 Precorrin-8x methylmutase CRN75_14500 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CRN75_14505 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CRN75_14510 ENOG4107XVH Transcriptional regulator CRN75_14515 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CRN75_14520 ENOG4105KNY Microcompartments protein CRN75_14525 ENOG4105EHR propanediol utilization protein pduB CRN75_14530 ENOG4105DMB glycerol dehydratase CRN75_14535 ENOG4105YCI dehydratase medium subunit CRN75_14540 ENOG4108ZFT Dehydratase small subunit CRN75_14545 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit CRN75_14555 ENOG4105KNY Microcompartments protein CRN75_14565 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) CRN75_14575 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml CRN75_14585 ENOG4108EKI Dehydrogenase CRN75_14595 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CRN75_14605 ENOG4105M3W utilization protein CRN75_14610 ENOG4105KTW ethanolamine utilization protein CRN75_14615 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CRN75_14620 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CRN75_14625 ENOG4107QZB decarboxylase CRN75_14630 ENOG4105JZC GHMP kinase CRN75_14640 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CRN75_14645 ENOG4105C2J ABC transporter CRN75_14650 ENOG4105CNN ABC, transporter CRN75_14660 ENOG41090HJ UPF0265 protein CRN75_14665 ENOG4105CHU acetyl-coa acetyltransferase CRN75_14670 ENOG4107QNJ CoA-transferase subunit B CRN75_14675 ENOG4107QP7 CoA-transferase subunit A CRN75_14690 ENOG4105D4T Citrate transporter CRN75_14710 ENOG4108N92 Thiol disulfide Interchange Protein CRN75_14715 ENOG4108MR7 Arylsulfotransferase CRN75_14730 ENOG4105CJB Exodeoxyribonuclease I CRN75_14735 ENOG4105CUB amino acid CRN75_14745 ENOG4107SCQ Iron-containing alcohol dehydrogenase CRN75_14750 ENOG4105C2J ABC transporter CRN75_14755 ENOG4105CNN ABC, transporter CRN75_14760 ENOG4108535 NAD dependent epimerase/dehydratase family CRN75_14765 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CRN75_14775 ENOG4105CIH Imidazole acetol-phosphate transaminase CRN75_14780 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CRN75_14785 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CRN75_14790 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CRN75_14800 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CRN75_14805 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CRN75_14810 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CRN75_14815 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CRN75_14830 ENOG4108DMA Nad-dependent epimerase dehydratase CRN75_14835 ENOG4105C0K Gdp-mannose 4,6-dehydratase CRN75_14845 ENOG4108KQJ Type 11 methyltransferase CRN75_14850 ENOG4105EY8 ABC transporter CRN75_14870 ENOG4105EE5 Membrane protein terC CRN75_14875 ENOG4105CEE C4-dicarboxylate transporter CRN75_14880 ENOG4108GAE asmA family CRN75_14890 ENOG4105DBI uridine monophosphokinase CRN75_14895 ENOG4105D1F ATP-binding protein CRN75_14900 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CRN75_14920 ENOG4105E5W Transporter CRN75_14925 ENOG4105VAW lrga family CRN75_14930 ENOG41067MG lrgb family CRN75_14940 ENOG4107R1I NAD-dependent malic enzyme CRN75_14945 ENOG4107GZ4 SanA protein CRN75_14955 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CRN75_14960 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) CRN75_14965 ENOG4108JPZ Monovalent cation H antiporter subunit D CRN75_14970 ENOG4107TDF Formate hydrogenlyase subunit 4 CRN75_14975 ENOG4105D65 subunit l CRN75_14980 ENOG4107WQX hydrogenase 4 membrane subunit CRN75_14985 ENOG4108JPZ Monovalent cation H antiporter subunit D CRN75_14990 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CRN75_15000 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit CRN75_15005 ENOG4105I6X formate hydrogenlyase maturation CRN75_15010 ENOG4108MG9 hydrogenase 3 maturation protease CRN75_15015 ENOG4108RC0 Electron transport protein CRN75_15020 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CRN75_15025 ENOG4108JUA Transcriptional regulator CRN75_15030 ENOG4105TMB Formate nitrite transporter CRN75_15035 ENOG4107SDZ Galactoside transport system permease protein mglC CRN75_15050 ENOG41060NJ transcriptional regulator CRN75_15055 ENOG4105DHF Membrane CRN75_15060 ENOG4105EUJ GTP cyclohydrolase i CRN75_15065 ENOG4105CBP Major Facilitator CRN75_15070 ENOG4105EGI Transcriptional regulator CRN75_15100 ENOG4105C19 ABC transporter CRN75_15110 ENOG4105CSH Transporter CRN75_15120 ENOG4105CVM Molybdenum cofactor synthesis domain protein CRN75_15125 ENOG4105D06 uba thif-type nad fad binding protein CRN75_15130 ENOG4105C5H ABC transporter CRN75_15150 ENOG4108T1M outer membrane protein x CRN75_15185 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) CRN75_15190 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction CRN75_15195 ENOG4105KSC Transcriptional regulator, TraR DksA family CRN75_15200 ENOG4107R0W ABC transporter CRN75_15205 ENOG4105E5Q amino acid AbC transporter CRN75_15210 ENOG4105CDA abc transporter atp-binding protein CRN75_15215 ENOG4107SDU Methyl-accepting chemotaxis CRN75_15220 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) CRN75_15230 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction CRN75_15240 ENOG4108MTB glycosyl transferase family CRN75_15245 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CRN75_15250 ENOG4105DVT helicase CRN75_15265 ENOG4105FDR Membrane CRN75_15285 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component CRN75_15290 ENOG4108IJ8 ABC transporter CRN75_15295 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component CRN75_15300 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system CRN75_15315 ENOG4105KHC sulfurtransferase CRN75_15320 ENOG4108IV0 ABC, transporter CRN75_15325 ENOG4108JJB ABC transporter CRN75_15330 ENOG4105CNN ABC, transporter CRN75_15335 ENOG4105C32 Amino acid ABC transporter (Permease) CRN75_15340 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein CRN75_15345 ENOG4108W15 Protein of unknown function (DUF1456) CRN75_15360 ENOG4105EHI Phosphonate ABC transporter, periplasmic CRN75_15370 ENOG4105Y3U Transglycosylase-associated protein CRN75_15380 ENOG4105N1F Hnh endonuclease CRN75_15390 ENOG4105CXG d-lactate dehydrogenase CRN75_15395 ENOG41061WM D-Alanyl-D-Alanine CRN75_15405 ENOG4105CJW magnesium transporter CRN75_15410 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) CRN75_15415 ENOG4105C1J atp-dependent rna helicase CRN75_15420 ENOG4107MVR Transcriptional regulator CRN75_15425 ENOG4105D0S secretion protein (HlyD CRN75_15430 ENOG4105CJ1 ABC, transporter CRN75_15435 ENOG4107QWP ABC-2 type transporter CRN75_15440 ENOG4107QWP ABC-2 type transporter CRN75_15445 ENOG4105HFZ Membrane CRN75_15450 ENOG4108ZAF Molybdopterin CRN75_15455 ENOG4105M00 molybdopterin converting factor, subunit 1 CRN75_15460 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CRN75_15465 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CRN75_15470 ENOG4105CHW UPF0052 protein CRN75_15475 ENOG4105VYA Uncharacterized conserved protein (DUF2132) CRN75_15480 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CRN75_15490 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CRN75_15495 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CRN75_15500 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CRN75_15505 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CRN75_15515 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CRN75_15525 ENOG4108K4B hydrolase CRN75_15535 ENOG4105E0C molybdate abc transporter CRN75_15540 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CRN75_15545 ENOG410680R Protein of unknown function (DUF2592) CRN75_15550 ENOG4105F4R Transcriptional regulator mode CRN75_15555 ENOG4105DKW ABC transporter CRN75_15565 ENOG4105CMR udp-glucose 4-epimerase CRN75_15570 ENOG4105F0Z galactose-1-phosphate uridylyltransferase CRN75_15575 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CRN75_15580 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CRN75_15590 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CRN75_15605 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CRN75_15610 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CRN75_15615 ENOG4105PGM cation diffusion facilitator family transporter CRN75_15620 ENOG4106Z1T Nicotinamide Mononucleotide Transporter CRN75_15625 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CRN75_15655 ENOG4105UFD tol-pal system protein YbgF CRN75_15660 ENOG4105KCK Peptidoglycan-associated lipoprotein CRN75_15665 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) CRN75_15670 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA CRN75_15670 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA CRN75_15675 ENOG4105M8F Biopolymer transport protein exbD tolR CRN75_15680 ENOG4105E02 MotA TolQ exbB proton channel CRN75_15685 ENOG4107YD3 Thioesterase CRN75_15690 ENOG4105KJB cyd operon protein YbgE CRN75_15700 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CRN75_15705 ENOG4105C4M (Ubiquinol oxidase) subunit I CRN75_15710 ENOG4105CGH 5'-nucleotidase CRN75_15715 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CRN75_15725 ENOG4105C7S Dehydrogenase CRN75_15730 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CRN75_15735 ENOG4105E33 succinate dehydrogenase CRN75_15745 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein CRN75_15750 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit CRN75_15755 ENOG4105BZN citrate synthase CRN75_15775 ENOG4105E7W lamb ycsf family protein CRN75_15780 ENOG4107R7A Allophanate hydrolase subunit 2 CRN75_15785 ENOG4105P4J Allophanate hydrolase, subunit 1 CRN75_15790 ENOG4107QNR UPF0135 protein CRN75_15795 ENOG4107RF4 Phosphodiesterase CRN75_15800 ENOG4105CVP deoxyribo-dipyrimidine photolyase CRN75_15805 ENOG4107SEY Conserved Protein CRN75_15820 ENOG4105XIQ Protein of unknown function (DUF2517) CRN75_15830 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CRN75_15835 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CRN75_15840 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CRN75_15845 ENOG4105C08 Histidine kinase CRN75_15850 ENOG4105EEX Two component transcriptional regulator (Winged helix family CRN75_15860 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 CRN75_15870 ENOG4105EV9 Alpha Beta Hydrolase CRN75_15875 ENOG4105NNH LexA regulated protein CRN75_15880 ENOG4105C8Q Methyl-accepting chemotaxis CRN75_15885 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) CRN75_15890 ENOG41090R7 Ferric uptake CRN75_15900 ENOG4105GX6 (LipO)protein CRN75_15915 ENOG4105CX6 glutaminyL-tRNA synthetase CRN75_15920 ENOG4105CI1 PTS System CRN75_15930 ENOG4105CE4 GlcNAc 6-P deacetylase CRN75_15935 ENOG4105E2R ROK family CRN75_15940 ENOG4105D4U had-superfamily hydrolase, subfamily iia CRN75_15945 ENOG4105CAQ asparagine synthetase CRN75_15980 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CRN75_15985 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CRN75_15990 ENOG4105C9A Phoh family CRN75_15995 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CRN75_16000 ENOG4108JU5 Magnesium and cobalt efflux protein CRN75_16005 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CRN75_16020 ENOG4107RP9 extracellular solute-binding protein, family 3 CRN75_16025 ENOG4105EAD ABC transporter CRN75_16030 ENOG4105DRP amino acid AbC transporter CRN75_16035 ENOG4105CDA abc transporter atp-binding protein CRN75_16045 ENOG4107PAI alpha helical protein CRN75_16055 ENOG4108U2H Rare lipoprotein B CRN75_16060 ENOG4105DJF DNA polymerase III, delta' subunit CRN75_16065 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CRN75_16070 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) CRN75_16080 ENOG4105CJN penicillin-binding protein CRN75_16085 ENOG4105CNI cell division protein FtsW CRN75_16090 ENOG4105K6T rare lipoprotein A CRN75_16095 ENOG4105DZ1 carboxypeptidase CRN75_16100 ENOG4108Z43 UPF0250 protein CRN75_16105 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CRN75_16110 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CRN75_16115 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) CRN75_16120 ENOG4105BZU Histidine kinase CRN75_16125 ENOG4107Z6W Protein CrcB homolog CRN75_16130 ENOG4105VEQ Cold shock protein CRN75_16140 ENOG4108N8T regulatoR CRN75_16150 ENOG4108R1E Serine threonine protein phosphatase 1 CRN75_16165 ENOG4108JJ7 ABC transporter CRN75_16180 ENOG4108Q2J Inner membrane protein YebE CRN75_16205 ENOG4108UYB regulatoR CRN75_16210 ENOG4105BZU Histidine kinase CRN75_16225 ENOG4105CW0 outer membrane usher protein CRN75_16230 ENOG4108AF8 Chaperone CRN75_16235 ENOG4108NAE Fimbrial chaperone protein CRN75_16245 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae CRN75_16270 ENOG4108TC1 Transcriptional regulator CRN75_16280 ENOG4108QZZ filamentous hemagglutinin CRN75_16280 ENOG4108QZZ filamentous hemagglutinin CRN75_16285 ENOG4105D5K Hemolysin activator protein CRN75_16295 ENOG4105CW0 outer membrane usher protein CRN75_16300 ENOG4105GQR Chaperone CRN75_16310 ENOG4108TC1 Transcriptional regulator CRN75_16330 ENOG4108KU3 Integrase CRN75_16340 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles CRN75_16345 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures CRN75_16355 ENOG4105W5Q DNA repair protein (RadC CRN75_16360 ENOG4105MFG Antirestriction protein CRN75_16390 ENOG4108KZE transcriptional regulator CRN75_16395 ENOG4108QDQ Ubiquinol-cytochrome C chaperone CRN75_16400 ENOG4106H6R UPF0380 protein CRN75_16440 ENOG4105D5K Hemolysin activator protein CRN75_16445 ENOG4105CKT filamentous hemagglutinin CRN75_16465 ENOG4105DFP Integrase CRN75_16475 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CRN75_16480 ENOG4105WQ3 Rna-binding protein CRN75_16485 ENOG4105C8N cysteinyl-tRNA synthetase CRN75_16490 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CRN75_16495 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) CRN75_16500 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CRN75_16505 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CRN75_16510 ENOG4105CV6 ABC transporter, permease CRN75_16515 ENOG4108I0Y (ABC) transporter CRN75_16520 ENOG4108UJV acyl-CoA thioesterase i CRN75_16525 ENOG4105E1F short-chain dehydrogenase reductase CRN75_16530 ENOG4107QR8 Thioredoxin CRN75_16535 ENOG4107QX8 SPFH domain, Band 7 family protein CRN75_16540 ENOG4105G5H Membrane CRN75_16545 ENOG4108Z6Z Transcriptional regulator CRN75_16550 ENOG4105C59 p-type ATPase CRN75_16555 ENOG4105MBR gumn family CRN75_16560 ENOG4108Z66 YbaK ebsC protein CRN75_16565 ENOG4105CGH 5'-nucleotidase CRN75_16570 ENOG4105EU0 Major facilitator Superfamily CRN75_16575 ENOG4105CKD glutathione-regulated potassium-efflux system protein CRN75_16580 ENOG4107RE1 Inosine-guanosine kinase CRN75_16585 ENOG4105CMR udp-glucose 4-epimerase CRN75_16600 ENOG4105ESV Glycosyl transferase, family 4 CRN75_16605 ENOG4107RJ7 Glycosyl transferase (Group 1 CRN75_16610 ENOG4105CG5 Glycosyl transferase (Group 1 CRN75_16615 ENOG4108SHN Glycosyl transferase, family 2 CRN75_16625 ENOG4105ER6 polysaccharide biosynthesis protein CRN75_16630 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CRN75_16635 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CRN75_16640 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CRN75_16645 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CRN75_16650 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CRN75_16655 ENOG4107QMP dna polymerase iii subunits gamma and tau CRN75_16660 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CRN75_16665 ENOG4105WD1 Membrane CRN75_16675 ENOG4106428 Protein of unknown function (DUF2496) CRN75_16680 ENOG4105EGS Mechanosensitive ion channel CRN75_16685 ENOG41090EX DsrE family CRN75_16690 ENOG4108IG5 Transcriptional regulator CRN75_16695 ENOG4105C1P efflux transporter, rnd family, mfp subunit CRN75_16700 ENOG4105BZS acriflavin resistance protein CRN75_16710 ENOG4108626 Racemase CRN75_16715 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CRN75_16720 ENOG4105NRA 50s ribosomal protein l31 type b CRN75_16725 ENOG4105YK5 50S ribosomal protein L36 CRN75_16730 ENOG4105DSE periplasmic solute binding protein CRN75_16735 ENOG4105CC5 ABC transporter CRN75_16740 ENOG4105DIK (ABC) transporter CRN75_16750 ENOG4108UKR Biofilm formation regulator YbaJ CRN75_16755 ENOG4105KF5 hemolysin expression-modulating protein CRN75_16760 ENOG4105TNG K13735 adhesin invasin CRN75_16765 ENOG4105DDW LysR family Transcriptional regulator CRN75_16775 ENOG41080UX Methyltransferase CRN75_16780 ENOG4108MNP Glycoprotein polysaccharide metabolism CRN75_16785 ENOG4105C29 acyl-CoA thioesterase CRN75_16790 ENOG4105BZU Histidine kinase CRN75_16795 ENOG4108YZA Nitrogen regulatory protein pii CRN75_16800 ENOG4105BZ1 (ABC) transporter CRN75_16805 ENOG4105BZ1 (ABC) transporter CRN75_16810 ENOG4108XM1 transcriptional regulator AsnC family CRN75_16815 ENOG4105C6T cysteine synthase CRN75_16820 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) CRN75_16825 ENOG4108NFA extracellular solute-binding protein CRN75_16830 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CRN75_16835 ENOG4108TGP Thioesterase superfamily protein CRN75_16840 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein CRN75_16845 ENOG4105EIN peptidylprolyl cis-trans isomerase CRN75_16850 ENOG4105K70 DNA-binding protein CRN75_16855 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CRN75_16860 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CRN75_16870 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CRN75_16880 ENOG4105M85 Bola protein CRN75_16885 ENOG4105IEY (LipO)protein CRN75_16890 ENOG4105EYM Major Facilitator superfamily CRN75_16895 ENOG4108NFH Sugar hydrolase CRN75_16900 ENOG4105E2S oxidase) subunit II CRN75_16905 ENOG4105BZ9 Cytochrome C oxidase, subunit I CRN75_16910 ENOG4105CCU oxidase (Subunit III) CRN75_16915 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) CRN75_16920 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CRN75_16925 ENOG4107RDB Major Facilitator CRN75_16930 ENOG4108VPT UPF0234 protein CRN75_16940 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CRN75_16945 ENOG4107S0N DJ-1 family CRN75_16950 ENOG4105CXY transporter CRN75_16955 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC CRN75_16965 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta CRN75_16970 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CRN75_16975 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CRN75_16980 ENOG4105CTB Polyprenyl synthetase CRN75_16985 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CRN75_16990 ENOG4108ZAI phosphatidylglycerophosphatase a CRN75_16995 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CRN75_17005 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CRN75_17010 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CRN75_17015 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CRN75_17025 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CRN75_17030 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CRN75_17035 ENOG4105VIE preprotein translocase, subunit YajC CRN75_17040 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CRN75_17045 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CRN75_17050 ENOG4108ZYK Acyl carrier protein phosphodiesterase CRN75_17055 ENOG4105D3R alkyl hydroperoxide reductase CRN75_17065 ENOG4105CHR reductase CRN75_17070 ENOG4107R28 alpha amylase, catalytic region CRN75_17075 ENOG4105C85 amino acid CRN75_17080 ENOG4105CWM branched-chain amino acid transport system II carrier protein CRN75_17090 ENOG4105BZU Histidine kinase CRN75_17095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CRN75_17105 ENOG4107RH8 nuclease SbcCD subunit D CRN75_17110 ENOG4105EYH Exonuclease CRN75_17115 ENOG4105DKQ ROK family CRN75_17120 ENOG4105DH7 May be involved in recombination (By similarity) CRN75_17125 ENOG4105NBK UPF0345 protein CRN75_17130 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CRN75_17150 ENOG4105F2W methyltransferase CRN75_17170 ENOG4105F8D glycoside hydrolase family 4 CRN75_17175 ENOG4105CI1 PTS System CRN75_17180 ENOG4105FDP GntR family transcriptional regulator CRN75_17185 ENOG4105D9N nucleoside CRN75_17190 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) CRN75_17195 ENOG4105DD7 kinase (PfkB family CRN75_17200 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CRN75_17205 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CRN75_17210 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) CRN75_17215 ENOG4105V1F Fermentation respiration switch protein CRN75_17225 ENOG4105CIN aminoacyl-histidine dipeptidase CRN75_17230 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CRN75_17245 ENOG4105WWK YheO domain protein CRN75_17250 ENOG4105CPF Cell wall formation (By similarity) CRN75_17265 ENOG4105CJ2 (LipO)protein CRN75_17270 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) CRN75_17275 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CRN75_17280 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CRN75_17285 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CRN75_17290 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CRN75_17295 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CRN75_17300 ENOG4105F7V ErfK ybiS ycfS ynhG family protein CRN75_17305 ENOG4105E7A Glutamine amidotransferase CRN75_17315 ENOG4107QPN acyl-Coa dehydrogenase CRN75_17320 ENOG4106YJS accessory processing protein CRN75_17335 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CRN75_17345 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CRN75_17350 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) CRN75_17355 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CRN75_17360 ENOG4105CHM Aminotransferase CRN75_17375 ENOG4105C5R Aminotransferase CRN75_17380 ENOG4105CDA abc transporter atp-binding protein CRN75_17385 ENOG4105E5Q amino acid AbC transporter CRN75_17420 ENOG4105EQ0 Major Facilitator superfamily CRN75_17425 ENOG4108UMN azlc family CRN75_17430 ENOG4105ZED uncharacterized protein ygaH CRN75_17435 ENOG4105NTK Transcriptional repressor Mpra CRN75_17440 ENOG4105ETP RND efflux system, outer membrane lipoprotein CRN75_17445 ENOG4105CW7 secretion protein, HlyD family CRN75_17450 ENOG4105C0R drug resistance transporter emrb qaca subfamily CRN75_17455 ENOG4105EIB trna rrna methyltransferase CRN75_17460 ENOG4105K63 Thioredoxin CRN75_17465 ENOG4106IUH DTW domain containing protein CRN75_17470 ENOG4105CD5 CoA-binding domain protein CRN75_17475 ENOG4105JIM Phosphatidylserine synthase CRN75_17480 ENOG4105T42 (LipO)protein CRN75_17515 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CRN75_17520 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CRN75_17525 ENOG4105C34 Pseudouridine synthase CRN75_17535 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CRN75_17540 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA CRN75_17550 ENOG4105CQC Prephenate dehydratase CRN75_17560 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CRN75_17565 ENOG4108NEV two component transcriptional regulator, LytTR family CRN75_17570 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CRN75_17575 ENOG4108NE3 Salt-induced outer membrane protein CRN75_17580 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CRN75_17585 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CRN75_17590 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CRN75_17595 ENOG4105K5M 30s ribosomal protein S16 CRN75_17600 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CRN75_17605 ENOG4106KVJ cytochrome C assembly protein CRN75_17610 ENOG4108JU6 CBS domain protein CRN75_17620 ENOG4105D9M gamma-glutamylcysteine synthetase CRN75_17625 ENOG4105W39 Membrane CRN75_17630 ENOG4107VXZ Hydrolase CRN75_17655 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CRN75_17660 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CRN75_17665 ENOG4105Y3E Modulates RecA activity (By similarity) CRN75_17670 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CRN75_17685 ENOG4105DKT Transcriptional regulator CRN75_17695 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CRN75_17700 ENOG4108IUS Transketolase CRN75_17705 ENOG4108HHA Transketolase CRN75_17710 ENOG4105CNN ABC, transporter CRN75_17715 ENOG4105C2J ABC transporter CRN75_17725 ENOG4105ETE Transcriptional regulator (LacI family CRN75_17730 ENOG4108NEM leader-binding protein dmsD CRN75_17735 ENOG4107KGK dmso reductase anchor subunit CRN75_17740 ENOG4105QAX Iron-sulfur CRN75_17745 ENOG4107QY8 reductase CRN75_17750 ENOG4105C0A alcohol dehydrogenase CRN75_17755 ENOG4107W7X Aldolase CRN75_17760 ENOG4105EDR glucose galactose transporter CRN75_17770 ENOG4105CMG Carbohydrate kinase CRN75_17780 ENOG4107EDW L-fucose operon activator CRN75_17785 ENOG41068CG regulatoR CRN75_17790 ENOG4105BZU Histidine kinase CRN75_17800 ENOG4105BZU Histidine kinase CRN75_17810 ENOG4108VEV chaperone CRN75_17815 ENOG4105CW0 outer membrane usher protein CRN75_17825 ENOG4107GFK fumarate CRN75_17835 ENOG4105C32 Amino acid ABC transporter (Permease) CRN75_17840 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CRN75_17845 ENOG4108IUZ ABC transporter CRN75_17850 ENOG4108IV0 ABC, transporter CRN75_17875 ENOG4105DKT Transcriptional regulator CRN75_17880 ENOG4108XCU pts system CRN75_17885 ENOG4105KPI PTS system sorbose subfamily IIB component CRN75_17890 ENOG4105ETZ PTS System CRN75_17895 ENOG4105F3R pts system mannose fructose sorbose family iid CRN75_17900 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein CRN75_17905 ENOG4105G63 Type III effector Hrp-dependent CRN75_17915 ENOG4105MVE transcriptional regulator CRN75_17920 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CRN75_17945 ENOG4105YVS arsR family transcriptional regulator CRN75_17950 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CRN75_17960 ENOG4105BZC d-serine deaminase CRN75_17965 ENOG4105C6Z Gluconate CRN75_17970 ENOG4105W8I Transcriptional regulator CRN75_17975 ENOG4108JQ7 (ABC) transporter CRN75_17985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CRN75_17990 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CRN75_17995 ENOG4105DEF Extracellular solute-binding protein, family 5 CRN75_18000 ENOG4105CXK mandelate racemase muconate lactonizing CRN75_18005 ENOG4105CA0 peroxidase CRN75_18015 ENOG4105E89 ABC transporter CRN75_18020 ENOG4105CHR reductase CRN75_18035 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CRN75_18040 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CRN75_18045 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CRN75_18050 ENOG4105DJY efflux transporter, rnd family, mfp subunit CRN75_18055 ENOG4108JJA ABC, transporter CRN75_18080 ENOG4105H8W Fimbrial protein CRN75_18085 ENOG4105NEV Fimbrial CRN75_18100 ENOG4108FZ9 Chaperone CRN75_18105 ENOG4106PG1 outer membrane usher protein CRN75_18130 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CRN75_18135 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CRN75_18140 ENOG4108K5P (LipO)protein CRN75_18145 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CRN75_18150 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) CRN75_18155 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) CRN75_18160 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CRN75_18170 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CRN75_18175 ENOG4106PMH Extracellular solute-binding protein family 3 CRN75_18180 ENOG4105DRP amino acid AbC transporter CRN75_18190 ENOG4105N0Z inner membrane protein ygbE CRN75_18195 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CRN75_18200 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) CRN75_18205 ENOG4105C11 sulfate adenylyltransferase), subunit 2 CRN75_18210 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CRN75_18220 ENOG4108MXK alkaline phosphatase isozyme conversion CRN75_18225 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CRN75_18230 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CRN75_18235 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CRN75_18240 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CRN75_18245 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CRN75_18260 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CRN75_18265 ENOG4105DXN mazG family CRN75_18270 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CRN75_18275 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CRN75_18280 ENOG4105BZU Histidine kinase CRN75_18285 ENOG4105C0H protease CRN75_18290 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein CRN75_18295 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CRN75_18305 ENOG4105EN6 Membrane CRN75_18315 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CRN75_18325 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CRN75_18335 ENOG4105S6R Iron-hydroxamate transporter permease subunit CRN75_18340 ENOG4105J76 Periplasmic binding protein CRN75_18345 ENOG4105E0A ABC, transporter CRN75_18350 ENOG4105BZ4 penicillin-binding protein CRN75_18355 ENOG4105CQ7 ATP-dependent helicase CRN75_18360 ENOG4107XID 2'-5' rna ligase CRN75_18365 ENOG4105PW4 Sugar fermentation stimulation protein homolog CRN75_18375 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters CRN75_18380 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) CRN75_18385 ENOG4105DJ0 Poly(A) Polymerase CRN75_18390 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CRN75_18395 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CRN75_18400 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CRN75_18405 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CRN75_18410 ENOG4107BJW polysaccharide deacetylase CRN75_18415 ENOG4105E3A (ABC) transporter CRN75_18420 ENOG4105DA5 (ABC) transporter CRN75_18425 ENOG41077A9 carbonic anhydrase CRN75_18430 ENOG4108UGV hypoxanthine phosphoribosyltransferase CRN75_18435 ENOG4105E3B Multicopper oxidase CRN75_18440 ENOG4108ZRK uncharacterized protein yacC CRN75_18445 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CRN75_18465 ENOG4105CKT filamentous hemagglutinin CRN75_18470 ENOG4105RPH Inner membrane protein YddG CRN75_18475 ENOG4108ZIG UPF0231 protein CRN75_18480 ENOG4107QIJ Aconitate hydratase 2 CRN75_18485 ENOG4107RNH Outer membrane receptor FepA CRN75_18500 ENOG4107QN2 dihydrolipoyl dehydrogenase CRN75_18505 ENOG4107QSN dihydrolipoamide acetyltransferase CRN75_18510 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CRN75_18515 ENOG41073TP transcriptional regulator CRN75_18520 ENOG4105C85 amino acid CRN75_18525 ENOG4105CT4 transporter CRN75_18530 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) CRN75_18535 ENOG4106A72 regulatory protein AmpE CRN75_18545 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CRN75_18550 ENOG4108ZUW Major pilin subunit CRN75_18555 ENOG4107QHF type ii secretion system protein e CRN75_18560 ENOG4105D7Q type ii secretion system CRN75_18565 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CRN75_18575 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CRN75_18585 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) CRN75_18590 ENOG4105M6F mutator MutT protein CRN75_18595 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CRN75_18600 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) CRN75_18615 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CRN75_18620 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CRN75_18625 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) CRN75_18635 ENOG4105DFU Cell wall formation (By similarity) CRN75_18640 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CRN75_18645 ENOG4105CNI cell division protein FtsW CRN75_18655 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CRN75_18660 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) CRN75_18665 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CRN75_18670 ENOG4105CJN penicillin-binding protein CRN75_18675 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CRN75_18680 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CRN75_18695 ENOG4107B7Y DNA-binding transcriptional regulator FruR CRN75_18700 ENOG4108ZP8 Acetolactate synthase small subunit CRN75_18705 ENOG4105C7K acetolactate synthase CRN75_18710 ENOG4108IQE Amp-dependent synthetase and ligase CRN75_18715 ENOG41064T2 transcriptional regulator, lysR family CRN75_18720 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CRN75_18725 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CRN75_18730 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CRN75_18745 ENOG4105C0F tryptophanase EC 4.1.99.1 CRN75_18750 ENOG4105CIC tryptophan-specific transport protein CRN75_18755 ENOG4105S8Q sugar efflux transporter CRN75_18760 ENOG4105C6N Formate acetyltransferase CRN75_18765 ENOG4105F1A Pyruvate formate-lyase CRN75_18770 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CRN75_18775 ENOG4105DP9 ABC transporter CRN75_18780 ENOG4106SMU thiamine transporter membrane protein CRN75_18790 ENOG4108KF1 Membrane CRN75_18795 ENOG4105CQ2 DNA polymerase CRN75_18805 ENOG4105D3G Pseudouridine synthase CRN75_18815 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) CRN75_18820 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) CRN75_18825 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) CRN75_18835 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CRN75_18840 ENOG4105NWN ApaG protein CRN75_18845 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CRN75_18855 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CRN75_18865 ENOG4105DWK Membrane CRN75_18870 ENOG4105N14 lysine exporter protein LysE YggA CRN75_18875 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CRN75_18880 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CRN75_18885 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CRN75_18890 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CRN75_18895 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase CRN75_18900 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CRN75_18905 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CRN75_18910 ENOG4105DTN riboflavin biosynthesis protein ribF CRN75_18925 ENOG41063Z6 transcriptional regulator, lysR family CRN75_18930 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CRN75_18935 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CRN75_18945 ENOG4106HK8 GPR1 FUN34 yaaH family protein CRN75_18960 ENOG4108RIR Molybdenum cofactor biosynthesis protein CRN75_18965 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CRN75_18975 ENOG4105D1Q UPF0246 protein CRN75_19000 ENOG410759A CRN75_19005 ENOG41065U4 response regulator CRN75_19010 ENOG4108RH0 Crea protein CRN75_19020 ENOG4105UEI Transcriptional Regulator AraC Family CRN75_19025 ENOG4105CVJ phosphoglycerate mutase CRN75_19030 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CRN75_19035 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) CRN75_19040 ENOG4107SC1 transglycosylase CRN75_19050 ENOG4108WS1 CRN75_19055 ENOG4108KHX Diguanylate cyclase CRN75_19060 ENOG41090EK ompa motb domain protein CRN75_19065 ENOG4105C5H ABC transporter CRN75_19105 ENOG4105C0A alcohol dehydrogenase CRN75_19120 ENOG4105CIS alcohol dehydrogenase CRN75_19125 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase CRN75_19130 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CRN75_19140 ENOG4105EAC phosphoserine phosphatase CRN75_19145 ENOG41062Z9 Membrane CRN75_19155 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CRN75_19160 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CRN75_19165 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CRN75_19170 ENOG4105D9N nucleoside CRN75_19175 ENOG4105EYA deoxyribonuclease CRN75_19180 ENOG4108NRW Phospholipase, patatin family CRN75_19190 ENOG4105K3G Periplasmic Protein CRN75_19195 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CRN75_19200 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CRN75_19205 ENOG4108WPU DNA polymerase III subunit psi CRN75_19215 ENOG4105CPC Aldo Keto reductase CRN75_19240 ENOG4105YBH Protein of unknown function (DUF1435) CRN75_19245 ENOG4106TD9 Diguanylate cyclase CRN75_19255 ENOG4105D7K pfkb domain protein CRN75_19270 ENOG4108HKT sucrose-6-phosphate hydrolase CRN75_19275 ENOG4105WBN Transcriptional regulator (LacI family CRN75_19280 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CRN75_19295 ENOG4106UW1 Major Facilitator superfamily CRN75_19325 ENOG4108UTZ Dihydroxyacetone kinase CRN75_19355 ENOG4105BZS acriflavin resistance protein CRN75_19360 ENOG410624X efflux transporter, rnd family, mfp subunit CRN75_19370 ENOG4105CEU Arginine dihydrolase CRN75_19375 ENOG4105D5Q Arginine ornithine antiporter CRN75_19385 ENOG4105DKP glycosyl transferase, family 9 CRN75_19390 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) CRN75_19395 ENOG4105DKT Transcriptional regulator CRN75_19405 ENOG4105C2J ABC transporter CRN75_19410 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CRN75_19415 ENOG4105F5R ABC transporter CRN75_19420 ENOG4105D4B ABC, transporter CRN75_19425 ENOG41061GT Aldolase CRN75_19430 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound CRN75_19445 ENOG4105RI1 glycoprotein receptor CRN75_19465 ENOG4105VEV -acetyltransferase CRN75_19470 ENOG4105EZE Cupin 4 family protein CRN75_19485 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CRN75_19490 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) CRN75_19495 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CRN75_19500 ENOG4105BZU Histidine kinase CRN75_19525 ENOG4105CKT filamentous hemagglutinin CRN75_19560 ENOG4105DHQ Histidine kinase CRN75_19590 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 CRN75_19600 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures CRN75_19605 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles CRN75_19610 ENOG4108XS9 dna repair protein CRN75_19625 ENOG4105TS0 gtp-binding protein CRN75_19635 ENOG4105JXR Protein of unknown function (DUF3296) CRN75_19680 ENOG4108K5H permease YjgP YjgQ family protein CRN75_19685 ENOG4108M8S permease YjgP YjgQ family protein CRN75_19690 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CRN75_19695 ENOG4105MYG DNA polymerase iii, chi subunit CRN75_19705 ENOG4108MJ3 acetyltransferase CRN75_19710 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) CRN75_19720 ENOG4105XEP YhcH YjgK YiaL family protein CRN75_19730 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CRN75_19735 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CRN75_19740 ENOG4105C3U ABC transporter CRN75_19745 ENOG4108JQ7 (ABC) transporter CRN75_19750 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CRN75_19755 ENOG410642W LysR family Transcriptional regulator CRN75_19760 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CRN75_19765 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) CRN75_19780 ENOG4107RJJ Transcriptional regulator CRN75_19785 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG CRN75_19790 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH CRN75_19795 ENOG4105EKV Phosphonate metabolism protein CRN75_19800 ENOG4105FT8 Phosphonate metabolism CRN75_19805 ENOG4105ENV phosphonate C-P lyase system protein PhnK CRN75_19810 ENOG4105HRV phosphonate c-p lyase system protein phnl CRN75_19815 ENOG4105FD8 phosphonate metabolism protein PhnM CRN75_19820 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) CRN75_19825 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein CRN75_19830 ENOG4105K4T epimerase CRN75_19835 ENOG4108ZPB UPF0306 protein CRN75_19850 ENOG4105DRS transport system, permease CRN75_19855 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CRN75_19875 ENOG4105CXN decarboxylase CRN75_19880 ENOG4105D5Q Arginine ornithine antiporter CRN75_19885 ENOG41082IR Excinuclease ABC C subunit domain protein CRN75_19890 ENOG4108YYD acetyltransferase CRN75_19895 ENOG4105XPQ lipid carrier protein CRN75_19900 ENOG4105CFP Peptidase U32 CRN75_19905 ENOG4106RZ4 Peptidase U32 CRN75_19925 ENOG4105DEN Luciferase family CRN75_19930 ENOG4105C1J atp-dependent rna helicase CRN75_19940 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CRN75_19950 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CRN75_19955 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CRN75_19960 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CRN75_19965 ENOG4105CHV Transcription elongation factor NusA CRN75_19995 ENOG4105EEI dihydropteroate synthase CRN75_20000 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CRN75_20005 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) CRN75_20010 ENOG4105HBR Rna-binding protein CRN75_20015 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CRN75_20020 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase CRN75_20035 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CRN75_20040 ENOG4105QYV Membrane CRN75_20055 ENOG4105EAH synthase CRN75_20065 ENOG4105HVQ Regulatory factor of maltose metabolism CRN75_20090 ENOG4105DFU Cell wall formation (By similarity) CRN75_20105 ENOG4105F0N pyrophosphate phospho-hydrolase CRN75_20110 ENOG4108ZHD aig2 family CRN75_20125 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CRN75_20130 ENOG4105C37 (CBS) domain CRN75_20135 ENOG41061GZ Protein of unknown function (DUF1107) CRN75_20140 ENOG4108UUE Transcriptional regulator CRN75_20145 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase CRN75_20150 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic CRN75_20160 ENOG4108V1T peptidylprolyl cis-trans isomerase CRN75_20165 ENOG4105FHY Opacity-associated protein A CRN75_20170 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CRN75_20175 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CRN75_20180 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) CRN75_20185 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CRN75_20200 ENOG4108MXZ Esterase CRN75_20205 ENOG4105WSB biofilm stress and motility protein A CRN75_20210 ENOG4105CSU acyl-Coa dehydrogenase CRN75_20215 ENOG4105C2N RNA methyltransferase TrmH family group 3 CRN75_20220 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CRN75_20230 ENOG4105KPV Transcriptional regulator CRN75_20235 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CRN75_20245 ENOG4105EPW hflc protein CRN75_20250 ENOG4107QJR hflk protein CRN75_20255 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CRN75_20260 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CRN75_20265 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CRN75_20270 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CRN75_20275 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CRN75_20280 ENOG4105K8N protein family UPF0079, ATPase CRN75_20285 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CRN75_20290 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CRN75_20315 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) CRN75_20325 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CRN75_20330 ENOG4105DJ4 phosphatidylserine decarboxylase CRN75_20335 ENOG4105EGS Mechanosensitive ion channel CRN75_20340 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) CRN75_20355 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) CRN75_20360 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) CRN75_20370 ENOG4105KPY Small multidrug resistance protein CRN75_20380 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CRN75_20385 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CRN75_20390 ENOG4108ZVF (LipO)protein CRN75_20400 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CRN75_20405 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CRN75_20420 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CRN75_20430 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CRN75_20435 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CRN75_20440 ENOG4105BZ8 glutamate synthase CRN75_20445 ENOG4105BZ8 glutamate synthase CRN75_20450 ENOG4105DJB Major Facilitator Superfamily CRN75_20455 ENOG4105CTX dehydratase CRN75_20460 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR CRN75_20465 ENOG4105BZW Glycerate kinase CRN75_20470 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CRN75_20475 ENOG4105CNV Aldolase CRN75_20480 ENOG4108SIC Transcriptional regulator CRN75_20515 ENOG4107F3C Hemin uptake protein CRN75_20520 ENOG4107ENK receptor CRN75_20525 ENOG4106QJH hemin transport protein CRN75_20530 ENOG4107R4I Periplasmic binding protein CRN75_20535 ENOG4105EHG Permease protein CRN75_20540 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CRN75_20545 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CRN75_20560 ENOG4105E0K tonB-dependent siderophore receptor CRN75_20565 ENOG4105EGS Mechanosensitive ion channel CRN75_20570 ENOG4105KSU Redox protein CRN75_20575 ENOG41066VF YeeE YedE family protein CRN75_20580 ENOG4108IUF type iii secretion CRN75_20585 ENOG4108TN6 type iii secretion CRN75_20590 ENOG41083GP type iii secretion CRN75_20595 ENOG4108HHI Type III secretion system protein CRN75_20615 ENOG4108JIR Flagellum-specific ATP synthase CRN75_20625 ENOG4106H1D secretion system apparatus protein CRN75_20630 ENOG4105UQF type iii secretion CRN75_20690 ENOG4108SZ7 secretion system effector CRN75_20700 ENOG4105ZQI secreted protein CRN75_20730 ENOG4105BZU Histidine kinase CRN75_20740 ENOG4105CK2 sodium dicarboxylate symporter CRN75_20745 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CRN75_20750 ENOG41062QD Membrane CRN75_20755 ENOG4107QN1 sodium solute CRN75_20800 ENOG4105DC1 bifunctional purine biosynthesis protein purh CRN75_20805 ENOG4105C12 Phosphoribosylglycinamide synthetase CRN75_20810 ENOG4108T8B Protein of unknown function (DUF1481) CRN75_20820 ENOG4105R2J Conserved Protein CRN75_20825 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) CRN75_20830 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CRN75_20835 ENOG4105E09 nadh pyrophosphatase CRN75_20840 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor CRN75_20845 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CRN75_20855 ENOG4105D06 uba thif-type nad fad binding protein CRN75_20860 ENOG4105WHD thiamine biosynthesis protein ThiS CRN75_20865 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CRN75_20870 ENOG4105D41 biosynthesis protein thiH CRN75_20875 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CRN75_20880 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CRN75_20895 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CRN75_20900 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CRN75_20905 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CRN75_20910 ENOG4105PM1 preprotein translocase subunit SecE CRN75_20945 ENOG4105CS9 pantothenic acid kinase CRN75_20950 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CRN75_20985 ENOG4108RR8 protoporphyrinogen oxidase CRN75_20990 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) CRN75_20995 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CRN75_21005 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CRN75_21010 ENOG4105CHU acetyl-coa acetyltransferase CRN75_21015 ENOG4107QK7 reductase CRN75_21020 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CRN75_21025 ENOG4105MDZ Transcriptional activator rfaH CRN75_21030 ENOG4105D52 delta-aminolevulinic acid dehydratase CRN75_21040 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CRN75_21045 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) CRN75_21050 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CRN75_21055 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) CRN75_21060 ENOG4105JC1 sterol-binding domain protein CRN75_21065 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CRN75_21070 ENOG4105CGY Dna recombination protein CRN75_21075 ENOG4108KF1 Membrane CRN75_21090 ENOG4108I5U Uridine phosphorylase CRN75_21095 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) CRN75_21100 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CRN75_21105 ENOG4105DZ2 Transcriptional regulator CRN75_21110 ENOG4105EMK carboxylate amino acid amine transporter CRN75_21115 ENOG4105RK9 auxin efflux carrier CRN75_21120 ENOG4107T6V glycerophosphoryl diester phosphodiesterase CRN75_21125 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CRN75_21130 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CRN75_21135 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component CRN75_21140 ENOG4105BZ7 extracellular solute-binding protein family 1 CRN75_21175 ENOG4108IV0 ABC, transporter CRN75_21180 ENOG4105C0Z ABC transporter CRN75_21185 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CRN75_21190 ENOG4105C32 Amino acid ABC transporter (Permease) CRN75_21195 ENOG4105CP9 extracellular ligand-binding receptor CRN75_21200 ENOG4105U59 -acetyltransferase CRN75_21210 ENOG4105CRP Part of the ABC transporter FtsEX involved in CRN75_21215 ENOG4105CAK Cell division ATP-binding protein ftsE CRN75_21220 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CRN75_21220 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CRN75_21225 ENOG4106H78 methyltransferase CRN75_21230 ENOG4105MG3 Membrane CRN75_21245 ENOG4107FS9 Membrane CRN75_21255 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) CRN75_21260 ENOG4105EX9 Membrane CRN75_21265 ENOG4108W1V Lipoprotein CRN75_21270 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CRN75_21280 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A CRN75_21285 ENOG4105CXY transporter CRN75_21290 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CRN75_21295 ENOG4105DQF Hydrolase CRN75_21300 ENOG4108EUD Lysophospholipase CRN75_21310 ENOG4105CCF Lysine exporter protein (Lyse ygga) CRN75_21315 ENOG4105C9U ATP-dependent DNA helicase RecQ CRN75_21320 ENOG4105HDD phospholipase CRN75_21325 ENOG4108VUY thioesterase Superfamily protein CRN75_21330 ENOG4105FR1 rard protein CRN75_21335 ENOG4107QUT magnesium and cobalt transport protein CorA CRN75_21345 ENOG4105EQN UPF0261 protein CRN75_21355 ENOG4105C4R Atp-dependent dna helicase CRN75_21360 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant CRN75_21365 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CRN75_21370 ENOG4105CT0 Protein of unknown function, DUF484 CRN75_21375 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CRN75_21380 ENOG4105S7Z (LipO)protein CRN75_21385 ENOG4105XQ6 frataxin-like protein CRN75_21400 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CRN75_21405 ENOG41076E6 Uroporphyrinogen-III Synthase CRN75_21410 ENOG4105ECF c-methyltransferase CRN75_21415 ENOG410601J HemY protein CRN75_21440 ENOG4105C85 amino acid CRN75_21455 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) CRN75_21460 ENOG4105EGZ biosynthesis protein CRN75_21465 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CRN75_21470 ENOG4108WJ1 acetyltransferase CRN75_21475 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CRN75_21480 ENOG4105C1B dTDP-glucose 4-6-dehydratase CRN75_21485 ENOG4108IJ1 Dehydrogenase CRN75_21490 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CRN75_21495 ENOG4105SFE lipopolysaccharide biosynthesis protein CRN75_21500 ENOG4105ESV Glycosyl transferase, family 4 CRN75_21510 ENOG4105K63 Thioredoxin CRN75_21520 ENOG4105C9X ppx gppa phosphatase CRN75_21530 ENOG4105C4R Atp-dependent dna helicase CRN75_21535 ENOG4105KQ5 peptidylprolyl cis-trans isomerase CRN75_21545 ENOG4108MQF Chaperone CRN75_21550 ENOG4105CW0 outer membrane usher protein CRN75_21560 ENOG4108VEV chaperone CRN75_21565 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CRN75_21570 ENOG4105EMY transcriptional regulator CRN75_21580 ENOG4105C7B Threonine dehydratase CRN75_21585 ENOG4105C01 Dihydroxy-acid dehydratase CRN75_21590 ENOG4105CM2 brancheD-chain amino acid aminotransferase CRN75_21595 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit CRN75_21615 ENOG4105C0P Mg chelatase subunit ChlI CRN75_21620 ENOG4108WFC UPF0438 protein yifE CRN75_21625 ENOG4105CVI Transcriptional regulator CRN75_21630 ENOG41062B0 ABC transporter, permease CRN75_21635 ENOG4107R9N ABC transporter CRN75_21640 ENOG4105C2J ABC transporter CRN75_21645 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator CRN75_21685 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CRN75_21695 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) CRN75_21700 ENOG4108Y73 Membrane CRN75_21710 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CRN75_21715 ENOG4105C5Q Transcriptional regulator CRN75_21720 ENOG4105EHV domain protein CRN75_21725 ENOG4107QN2 dihydrolipoyl dehydrogenase CRN75_21735 ENOG4107QZV Type I secretion membrane fusion protein CRN75_21755 ENOG4105X58 receptor CRN75_21760 ENOG4105CH7 arginosuccinase CRN75_21765 ENOG4105CAS nag kinase CRN75_21770 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CRN75_21780 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) CRN75_21785 ENOG4105SYT Methylenetetrahydrofolate reductase CRN75_21790 ENOG4105CFH Aspartokinase CRN75_21795 ENOG4105C28 cystathionine CRN75_21800 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) CRN75_21810 ENOG4105C25 Primosomal protein n' CRN75_21815 ENOG4105ETE Transcriptional regulator (LacI family CRN75_21820 ENOG41063M6 Cell Division Protein CRN75_21825 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CRN75_21830 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CRN75_21835 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CRN75_21840 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) CRN75_21845 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) CRN75_21860 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CRN75_21865 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CRN75_21870 ENOG4105CBT Fructose-1,6-bisphosphatase CRN75_21875 ENOG4105E5M Multidrug resistance protein D CRN75_21880 ENOG4105DP0 ferredoxin-NADP reductase CRN75_21885 ENOG4108VTS Membrane CRN75_21890 ENOG4105EBK exported protein CRN75_21905 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CRN75_21915 ENOG41076HS cation diffusion facilitator family transporter CRN75_21920 ENOG4105FMW periplasmic CRN75_21925 ENOG4105E3W Two component transcriptional regulator (Winged helix family CRN75_21930 ENOG4105E0F Histidine kinase CRN75_21935 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CRN75_21940 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CRN75_21945 ENOG4105D7W serine acetyltransferase CRN75_21950 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CRN75_21960 ENOG4105VW4 glutaredoxin 3 CRN75_21965 ENOG4107YZP Rhodanese domain protein CRN75_21970 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CRN75_21975 ENOG41063SB peptidase CRN75_21980 ENOG4105PXI polysaccharide deacetylase CRN75_21990 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CRN75_21995 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CRN75_22000 ENOG4105XA0 heptosyltransferase ii CRN75_22005 ENOG4105D16 lipopolysaccharide heptosyltransferase i CRN75_22010 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase CRN75_22020 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CRN75_22025 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CRN75_22030 ENOG4105W0E 50S ribosomal protein L33 CRN75_22035 ENOG4105KDC 50s ribosomal protein l28 CRN75_22040 ENOG4105W5Q DNA repair protein (RadC CRN75_22045 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CRN75_22050 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CRN75_22055 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CRN75_22060 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CRN75_22070 ENOG4105DSJ YicC domain protein CRN75_22085 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CRN75_22095 ENOG4107RSM transcriptional regulator CRN75_22100 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CRN75_22120 ENOG4105BZU Histidine kinase CRN75_22125 ENOG4105E39 Enoyl-CoA hydratase CRN75_22130 ENOG4105D9N nucleoside CRN75_22140 ENOG4105EN6 Membrane CRN75_22145 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) CRN75_22155 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CRN75_22160 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CRN75_22165 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase CRN75_22170 ENOG4105CB5 ATP-dependent DNA helicase recG CRN75_22175 ENOG4105D6U Sodium Glutamate Symporter CRN75_22180 ENOG4105C2W permease CRN75_22185 ENOG4105JV1 AsmA family CRN75_22215 ENOG4105HVQ Regulatory factor of maltose metabolism CRN75_22220 ENOG4105SUU thioesterase domain CRN75_22230 ENOG4107S2Z UPF0761 membrane protein CRN75_22235 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 CRN75_22245 ENOG4105C5F glutamine synthetase CRN75_22250 ENOG4105CUX Signal transduction histidine kinase CRN75_22255 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CRN75_22260 ENOG4105D4P Coproporphyrinogen iii oxidase CRN75_22270 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) CRN75_22275 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CRN75_22280 ENOG4105C2M dna polymerase I CRN75_22285 ENOG4108Z33 Thiol disulfide Interchange Protein CRN75_22290 ENOG4105E27 serine threonine protein kinase CRN75_22295 ENOG4105PC1 Conserved Protein CRN75_22305 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b CRN75_22340 ENOG4107EJG GntR family transcriptional regulator CRN75_22345 ENOG4105C0R drug resistance transporter emrb qaca subfamily CRN75_22350 ENOG4105ETE Transcriptional regulator (LacI family CRN75_22355 ENOG4108RVA ribokinase CRN75_22360 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CRN75_22365 ENOG4105CNN ABC, transporter CRN75_22375 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) CRN75_22385 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) CRN75_22390 ENOG4105EV2 VWA domain protein interacting with AAA ATPase CRN75_22405 ENOG4108VVK transcriptional Regulator, AsnC CRN75_22410 ENOG4105QTB Flavodoxin CRN75_22420 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CRN75_22425 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CRN75_22430 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation CRN75_22435 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) CRN75_22440 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CRN75_22445 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CRN75_22450 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CRN75_22455 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CRN75_22460 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CRN75_22465 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CRN75_22470 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CRN75_22475 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CRN75_22480 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CRN75_22485 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) CRN75_22490 ENOG4105C8U phosphate abc transporter CRN75_22495 ENOG4105E2Z phosphate ABC transporter (Permease CRN75_22515 ENOG4106PMH Extracellular solute-binding protein family 3 CRN75_22520 ENOG4105EAD ABC transporter CRN75_22525 ENOG4105DRP amino acid AbC transporter CRN75_22535 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 CRN75_22540 ENOG4105C7N Xanthine uracil vitamin C permease CRN75_22555 ENOG4105BZU Histidine kinase CRN75_22560 ENOG4108YYH Nadph-dependent fmn reductase CRN75_22565 ENOG4105C8Q Methyl-accepting chemotaxis CRN75_22570 ENOG4108UMI ABC transporter, permease CRN75_22575 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CRN75_22585 ENOG4105RKW reductase (By CRN75_22590 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CRN75_22595 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CRN75_22605 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CRN75_22610 ENOG4105VG0 50S ribosomal protein l34 CRN75_22620 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CRN75_22625 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)