locus-tag class description AW19_10 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein AW19_100 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AW19_1000 ENOG4105C3G gtp-binding protein AW19_1002 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AW19_1003 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria AW19_1004 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AW19_1006 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AW19_1007 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AW19_1008 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AW19_1009 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AW19_1010 ENOG4108YY7 Invasion gene expression up-regulator SirB AW19_1011 ENOG41063JG Transcriptional regulator AW19_1012 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AW19_1013 ENOG4105CHH sulfate transporter AW19_1019 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AW19_102 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW19_1020 ENOG4107SSZ Phosphatase AW19_1021 ENOG4107XHZ cytoplasmic chaperone TorD family protein AW19_1022 ENOG4105F3T (LipO)protein AW19_1023 ENOG4105EV4 Multidrug resistance protein mdtH AW19_1024 ENOG4105D9U N-acetyltransferase AW19_1026 ENOG4105EP9 oxidoreductase AW19_1027 ENOG4105CJR Integral membrane protein (MviN AW19_1028 ENOG4105C75 arginyL-tRNA synthetase AW19_1029 ENOG4106ZCM YecM protein AW19_1030 ENOG4106N3A copper homeostasis protein cutc AW19_1031 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AW19_1032 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) AW19_1033 ENOG4105WJG Glutathione AW19_1034 ENOG41081XQ Conserved Protein AW19_1035 ENOG4105D3W isochorismatase AW19_1036 ENOG4105C9M aspartyl-trna synthetase AW19_1037 ENOG4108TIT dATP pyrophosphohydrolase AW19_1038 ENOG4105CDY transcriptional regulatory protein AW19_1039 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AW19_104 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) AW19_1040 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AW19_1041 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AW19_1042 ENOG4105DUX Transporter AW19_1043 ENOG4105FAV ABC, transporter AW19_1044 ENOG4105FDK ABC transporter AW19_1045 ENOG4105NXV High-affinity zinc uptake system protein AW19_1046 ENOG4105DR5 peptidase AW19_1047 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase AW19_1048 ENOG4105CA9 Pyruvate kinase AW19_1049 ENOG4106KNT transcriptional regulator AW19_1050 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AW19_1051 ENOG4108UHU Aldolase AW19_1052 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) AW19_1054 ENOG4105M4H endoribonuclease L-psp AW19_1055 ENOG4105DVT helicase AW19_1056 ENOG41072GX Peptidase M22 Glycoprotease AW19_1057 ENOG4105Y4Z Outer Membrane Lipoprotein AW19_1058 ENOG4105CEY Amp-dependent synthetase and ligase AW19_1059 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AW19_1060 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) AW19_1061 ENOG4107QMS site-determining protein AW19_1062 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AW19_1064 ENOG4105VNG YcgL domain-containing protein AW19_1065 ENOG4105CVE Lytic murein transglycosylase AW19_1066 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AW19_1067 ENOG4108ZZ3 UPF0260 protein AW19_1069 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AW19_107 ENOG4105KI2 Urea amidohydrolase subunit beta AW19_1070 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) AW19_1071 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AW19_1072 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) AW19_1073 ENOG4105ED1 spovr family AW19_1074 ENOG4105MWK D-amino acid dehydrogenase, small subunit AW19_1075 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AW19_1076 ENOG4105CNH Multidrug resistance protein MdtL AW19_1077 ENOG4105BZU Histidine kinase AW19_1078 ENOG4105EUB pirin domain protein AW19_1079 ENOG4105HEI LysR family (Transcriptional regulator AW19_108 ENOG4105CQM Urea amidohydrolase subunit alpha AW19_1081 ENOG4106AKX UPF0229 protein AW19_1082 ENOG4105CYN Serine protein kinase AW19_1083 ENOG4105GNX MltA-interacting MipA family protein AW19_1084 ENOG4105DSB aldose 1-epimerase AW19_1086 ENOG4105E0X reductase AW19_1087 ENOG4105VUT cytoplasmic protein AW19_1088 ENOG4108RWI nicotinamidase AW19_1089 ENOG4105HDK L-asparaginase AW19_1090 ENOG4105D07 Signal peptide peptidase, SppA AW19_1091 ENOG41069NU Nitroreductase AW19_1093 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AW19_1094 ENOG4105MTM Protein of unknown function (DUF1496) AW19_1095 ENOG4105M6F mutator MutT protein AW19_1096 ENOG4105CGK Exodeoxyribonuclease III AW19_1097 ENOG4105SKE transcriptional Regulator LysR family AW19_11 ENOG4105F3R pts system mannose fructose sorbose family iid AW19_1101 ENOG4105CIY formyltetrahydrofolate deformylase AW19_1102 ENOG4105K5B UPF0225 protein AW19_1104 ENOG4105D78 K07001 NTE family protein AW19_1105 ENOG4105I93 response regulator AW19_1106 ENOG4105C6Y Udp-glucose 6-dehydrogenase AW19_1108 ENOG4107104 thymidine kinase AW19_111 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) AW19_1111 ENOG4108EKI Dehydrogenase AW19_1112 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AW19_1113 ENOG4107QSI ABC, transporter AW19_1114 ENOG4107QSI ABC, transporter AW19_1115 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW19_1116 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW19_1117 ENOG4105C3U ABC transporter AW19_1118 ENOG4108JQ7 (ABC) transporter AW19_112 ENOG4108XNJ Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AW19_1120 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW19_1121 ENOG4105CMB EAL domain-containing protein AW19_1124 ENOG4105K9H YciI-like protein AW19_1125 ENOG410822N TonB family AW19_1126 ENOG4105NAU thioesterase Superfamily protein AW19_1127 ENOG4107835 probably involved in intracellular septation (By similarity) AW19_1129 ENOG4108S3I UPF0259 membrane protein AW19_1130 ENOG4105EIF outer membrane protein W AW19_1132 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AW19_1133 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AW19_1134 ENOG4105DK0 Indole-3-glycerol phosphate synthase AW19_1136 ENOG4105DDQ anthranilate synthase AW19_1137 ENOG4105CRQ synthase (Component I) AW19_1138 ENOG4105DB7 PHP domain protein AW19_1139 ENOG4107RTD sua5 ycio yrdc ywlc family protein AW19_1141 ENOG4108Q9V regulatoR AW19_1147 ENOG4108UDW Transcriptional regulator, luxr family AW19_115 ENOG4105XXV Acid-resistance protein AW19_1159 ENOG4105FE9 pseudouridine synthase AW19_116 ENOG4107SVH Potassium channel protein AW19_1161 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AW19_1162 ENOG4105UBK short-chain dehydrogenase reductase AW19_1163 ENOG4105ERU peptidase AW19_1164 ENOG4105RKX Protein of unknown function (DUF2498) AW19_1165 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AW19_1166 ENOG4107R11 Transcriptional regulator AW19_1169 ENOG4107QM5 aconitate hydratase AW19_117 ENOG41086WQ Protein CrcB homolog AW19_1170 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AW19_1171 ENOG4105EYK Phosphatidylglycerophosphatase B AW19_1172 ENOG4105Q4A inner membrane protein yciS AW19_1173 ENOG4105CFV Tetratricopeptide repeat protein AW19_1175 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction AW19_1176 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AW19_1177 ENOG4108ZJT translation initiation factor, Sui1 AW19_1178 ENOG41061RM osmotically inducible lipoprotein AW19_1179 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase AW19_1181 ENOG4105N2W Transcriptional regulator AW19_1182 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AW19_1183 ENOG4105VCD cytoplasmic protein AW19_1184 ENOG4105D22 carbon starvation protein AW19_1185 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) AW19_1187 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AW19_119 ENOG4105CPC Aldo Keto reductase AW19_1191 ENOG4105CSM endonuclease III AW19_1193 ENOG4108UQQ Electron transport complex AW19_1194 ENOG4105D6A Electron transport complex AW19_1195 ENOG4105UEI Transcriptional Regulator AraC Family AW19_1196 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) AW19_1199 ENOG4105M9B inner membrane protein ydgK AW19_12 ENOG4105ETZ PTS System AW19_120 ENOG4105D8V Glucose sorbosone dehydrogenase AW19_1200 ENOG4105CKU formyltetrahydrofolate synthetase AW19_1202 ENOG4105C42 Type I secretion membrane fusion protein (HlyD AW19_1204 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AW19_1205 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) AW19_121 ENOG4105VZJ PTS System AW19_1211 ENOG4105D9R oxidoreductase AW19_1212 ENOG4105DHU Bile acid AW19_1213 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AW19_1214 ENOG4105C87 Aminotransferase class I and II AW19_1215 ENOG4105CI1 PTS System AW19_1217 ENOG4107P2S Transcriptional regulator AW19_122 ENOG4105CK1 PTS System AW19_1220 ENOG4106J39 exported protein AW19_1221 ENOG4105EIP mannose-6-phosphate isomerase AW19_1222 ENOG4105C9Q fumarate hydratase class II AW19_1224 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) AW19_1226 ENOG4105D94 Major Facilitator Superfamily AW19_1227 ENOG4106NZI LysR family Transcriptional regulator AW19_1228 ENOG4105DAG ROK family AW19_1229 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AW19_123 ENOG4105CS2 ec 3.2.1.21 AW19_1231 ENOG4105KBG Protein of unknown function (DUF1161) AW19_1233 ENOG4105KK4 UPF0060 membrane protein AW19_1234 ENOG4105EMU Dehydrogenase AW19_1235 ENOG4108BUD transposase AW19_1237 ENOG4105ETS cytosine purines uracil thiamine allantoin AW19_1238 ENOG4105E45 Histidinol-phosphate aminotransferase AW19_124 ENOG4105VCP PTS System AW19_1242 ENOG4105KBH arsR family transcriptional regulator AW19_1249 ENOG4105DZS Phenylacetate-CoA ligase AW19_125 ENOG4105EZV Transcriptional regulator AW19_1253 ENOG4105CYM Glutathione S-transferase AW19_1254 ENOG4108JUA Transcriptional regulator AW19_1255 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center AW19_1256 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase AW19_1258 ENOG4108RYR transcriptional regulator AsnC family AW19_126 ENOG410901P UPF0249 protein AW19_1260 ENOG4105DSP amino acid AbC transporter AW19_1261 ENOG4105E89 ABC transporter AW19_1262 ENOG4106V2I dimethylaminohydrolase AW19_1264 ENOG4105FYV Amp nucleosidase AW19_1268 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AW19_127 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures AW19_1270 ENOG4105C7K acetolactate synthase AW19_1271 ENOG4105M71 acetolactate synthase 1 regulatory subunit AW19_1272 ENOG4105PAD Hydrolase AW19_1275 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AW19_1278 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) AW19_128 ENOG4105W5Q DNA repair protein (RadC AW19_1281 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AW19_1282 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AW19_1283 ENOG4105Q9Y Universal stress protein AW19_1284 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AW19_1285 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AW19_1286 ENOG4105C5D exported protein AW19_1287 ENOG4105D5Q Arginine ornithine antiporter AW19_1289 ENOG4107EXC regulatoR AW19_129 ENOG4106H6R UPF0380 protein AW19_1290 ENOG4105JJR Histidine kinase AW19_1291 ENOG4105CTD carboxy-peptidase AW19_1294 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap AW19_1297 ENOG4105CQ7 ATP-dependent helicase AW19_1298 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AW19_1299 ENOG4105WXT Conserved Protein AW19_13 ENOG4105KPI PTS system sorbose subfamily IIB component AW19_1300 ENOG410689M (LipO)protein AW19_1301 ENOG4107H52 Dicarboxylate transport AW19_1302 ENOG4105C5I Dehydrogenase AW19_1304 ENOG4105KT7 mgtC SapB transporter AW19_1306 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) AW19_1308 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AW19_1309 ENOG4107RX3 Mg2 transporter protein cora family protein AW19_1311 ENOG4107QSI ABC, transporter AW19_1312 ENOG4107S8C mandelate racemase muconate lactonizing AW19_1313 ENOG4105KXI murein peptide amidase A AW19_1314 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AW19_1318 ENOG4106K28 UPF0283 membrane protein AW19_1319 ENOG4105CM6 amino acid regulated cytosolic protein AW19_1321 ENOG4105FM1 phage shock protein C AW19_1322 ENOG4105YYT phage shock protein B AW19_1323 ENOG41087YS Phage shock protein A AW19_1324 ENOG4105E51 psp operon transcriptional activator AW19_1326 ENOG4106DF6 pertussis toxin subunit 1 AW19_1327 ENOG4108HIY periplasmic AW19_1328 ENOG4108I5W peptide transport system, permease protein AW19_1329 ENOG4108EU3 peptide transport system, permease AW19_1330 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein AW19_1331 ENOG4108JQ2 peptide transport system atp-binding protein AW19_1332 ENOG4105Q4T oxidoreductase AW19_1333 ENOG4105DUM transcriptional regulator, lysR family AW19_1334 ENOG4105DUX Transporter AW19_1336 ENOG41069YE inner membrane protein yohC AW19_1337 ENOG4108ZR5 Conserved Protein AW19_1338 ENOG4108K3A Glutathione S-transferase AW19_1340 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AW19_1342 ENOG410642K Lysozyme inhibitor AW19_1343 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AW19_1344 ENOG4108XTF Outer Membrane Lipoprotein AW19_1345 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) AW19_1347 ENOG4105Y49 secretion protein, HlyD family AW19_1348 ENOG4105DSW Fusaric acid resistance protein AW19_1349 ENOG4107RGM aldo keto reductase AW19_1351 ENOG4105XZD Fe-S protein AW19_1353 ENOG4105DIJ Phosphoethanolamine transferase AW19_1354 ENOG4108WUH Transcriptional regulator, TetR family AW19_1355 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AW19_1356 ENOG4108UYE Lactoylglutathione lyase AW19_1357 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AW19_1358 ENOG4105M2J Glutaredoxin AW19_1359 ENOG4105K4H Nlp p60 protein AW19_136 ENOG410679B prophage CP4-57 regulatory protein alpA AW19_1360 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW19_1362 ENOG4105ETE Transcriptional regulator (LacI family AW19_1363 ENOG4105F52 Transcriptional regulator AW19_1364 ENOG4105CZQ inner membrane transport protein YdhC AW19_1365 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AW19_1366 ENOG4108R6K riboflavin synthase, subunit alpha AW19_1367 ENOG4107QI1 Mate efflux family protein AW19_1371 ENOG4105CA9 Pyruvate kinase AW19_1372 ENOG4105KMX major outer membrane lipoprotein AW19_1373 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AW19_1374 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AW19_1376 ENOG4105JRK feS assembly protein SufD AW19_1377 ENOG4105C3K feS assembly ATPase SufC AW19_1378 ENOG4105DIW FeS assembly protein SUFB AW19_1379 ENOG4108Z4V iron-sulfur cluster assembly AW19_1380 ENOG4105KA0 thioesterase Superfamily protein AW19_1381 ENOG4105CQB FAD linked oxidase domain protein AW19_1382 ENOG4105IPI Membrane AW19_1383 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AW19_1384 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AW19_1385 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AW19_1386 ENOG4107ENK receptor AW19_1387 ENOG4106QJH hemin transport protein AW19_1388 ENOG4107R4I Periplasmic binding protein AW19_1390 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) AW19_1391 ENOG4108QBX (LipO)protein AW19_1392 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) AW19_1393 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) AW19_1394 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AW19_1395 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AW19_1396 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AW19_1397 ENOG4105CKK Glycosyl transferase, family 2 AW19_1398 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AW19_1399 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) AW19_14 ENOG4108XCU pts system AW19_1400 ENOG4108V06 Glutathione peroxidase AW19_1401 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) AW19_1403 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme AW19_1404 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AW19_1408 ENOG41082NX 50s ribosomal protein l35 AW19_1409 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AW19_1410 ENOG4105C22 threonyL-tRNA synthetase AW19_1414 ENOG4108UQV Membrane AW19_1419 ENOG41082NP Multiple antibiotic resistance AW19_1420 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division AW19_1421 ENOG4105DSE periplasmic solute binding protein AW19_1422 ENOG4105DIK (ABC) transporter AW19_1423 ENOG4105CC5 ABC transporter AW19_1424 ENOG4105CC5 ABC transporter AW19_1425 ENOG4105FGM Fructosamine kinase AW19_1426 ENOG4107PN8 YfeABCD locus regulator AW19_1427 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 AW19_1428 ENOG4105M5J Cupin 2, conserved barrel domain protein AW19_1429 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) AW19_1430 ENOG4105CHR reductase AW19_1431 ENOG41061NF Pectate lyase AW19_1432 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AW19_1433 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AW19_1434 ENOG4108IJ9 (ABC) transporter AW19_1435 ENOG4105WEM extracellular solute-binding protein AW19_1436 ENOG4108PU9 oligogalacturonate-specific porin AW19_1437 ENOG4107K5X Membrane-bound metal-dependent hydrolase AW19_1438 ENOG4108ETY sodium dicarboxylate symporter AW19_1439 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AW19_144 ENOG4105DFP Integrase AW19_1441 ENOG4105CAZ oligogalacturonide lyase AW19_1442 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW19_1444 ENOG4105D0M Protease HtpX homolog AW19_1445 ENOG4105CN1 protease AW19_1447 ENOG4108ZGC gaf domain protein AW19_1448 ENOG4105H2K paraquat-inducible protein a AW19_1449 ENOG4105DY2 Paraquat-inducible protein b AW19_145 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AW19_1451 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW19_1459 ENOG4105WT8 Protein of unknown function (DUF1480) AW19_146 ENOG4108Z1B Cyclase dehydrase AW19_1466 ENOG4105D64 Mechanosensitive ion channel AW19_1472 ENOG4105D6U Sodium Glutamate Symporter AW19_1473 ENOG4105FE9 pseudouridine synthase AW19_1474 ENOG41066YJ Beta-lactamase AW19_1477 ENOG4105K4U addiction module toxin, RelE StbE family AW19_148 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AW19_1480 ENOG4105NKT exported protein AW19_1481 ENOG4108PNC copper resistance AW19_1482 ENOG4105FXM Copper resistance protein AW19_1483 ENOG41090A1 ferritin AW19_1484 ENOG4105MPK DNA polymerase III subunit theta AW19_1487 ENOG4105UMD exodeoxyribonuclease X AW19_1488 ENOG4105CUG Oligopeptidase b AW19_149 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AW19_1490 ENOG4105N5Z UPF0267 protein AW19_1491 ENOG4105X2V dna damage-inducible protein AW19_1492 ENOG4105C1J atp-dependent rna helicase AW19_1493 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AW19_1494 ENOG4105X5C UPF0181 protein AW19_1495 ENOG4105CRQ synthase (Component I) AW19_1496 ENOG4105P8F nudix hydrolase AW19_1497 ENOG4105EJQ L-serine dehydratase AW19_1499 ENOG4105EE5 Membrane protein terC AW19_15 ENOG4105CHR reductase AW19_150 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AW19_1500 ENOG4108EQA pts system AW19_1501 ENOG4105ETZ PTS System AW19_1502 ENOG4105F3R pts system mannose fructose sorbose family iid AW19_1503 ENOG4108NK4 UPF0266 membrane protein AW19_1504 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) AW19_1506 ENOG4105BZU Histidine kinase AW19_1508 ENOG4105DHI Methyltransferase AW19_1509 ENOG4105CJN penicillin-binding protein AW19_151 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AW19_1510 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AW19_1511 ENOG4105VEQ Cold shock protein AW19_1512 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) AW19_1513 ENOG4105C85 amino acid AW19_1516 ENOG41064PC AW19_1517 ENOG4105TIK AW19_1518 ENOG4105N4N Protein of unknown function (DUF2766) AW19_152 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AW19_1523 ENOG4105D5Q Arginine ornithine antiporter AW19_1525 ENOG4105BZ1 (ABC) transporter AW19_1528 ENOG4105XXV Acid-resistance protein AW19_1529 ENOG4105VTN Protein of unknown function (DUF1311) AW19_153 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) AW19_1532 ENOG4105KVH Transcriptional regulator AW19_1533 ENOG4105ECR NmrA family AW19_1534 ENOG4108IQK o-acetylhomoserine AW19_1535 ENOG4105ECQ AraC Family Transcriptional Regulator AW19_1537 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AW19_154 ENOG4105C1J atp-dependent rna helicase AW19_1540 ENOG4106NDP Transcriptional regulator AW19_1544 ENOG4108HMX isocitrate dehydrogenase (NADP) AW19_1545 ENOG4108R99 pseudouridine synthase AW19_1547 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AW19_1548 ENOG41075W9 High frequency lysogenization protein HflD homolog AW19_1549 ENOG4107QTF adenylosuccinate lyase AW19_155 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) AW19_1551 ENOG4105XJC Two component transcriptional regulator (Winged helix family AW19_1553 ENOG4105EZE Cupin 4 family protein AW19_1555 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AW19_1556 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) AW19_1557 ENOG4105D60 lipoprotein releasing system transmembrane protein AW19_1559 ENOG4105D60 lipoprotein releasing system transmembrane protein AW19_156 ENOG4108IYU L-aspartate oxidase AW19_1560 ENOG4108JA2 transcriptioN-repair coupling factor AW19_1561 ENOG4107MBR 17 kDa surface antigen AW19_1563 ENOG4105CEP NADH dehydrogenase AW19_1564 ENOG4105D0Y UPF0227 protein AW19_1565 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AW19_1566 ENOG4108RUM thiamine kinase AW19_1567 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) AW19_1568 ENOG41090DQ Lipoprotein AW19_1569 ENOG4105K59 histidine triad (HIT) protein AW19_1570 ENOG4105F9E Shikimate 5-dehydrogenase AW19_1573 ENOG4105C4X radical SAM domain protein AW19_1575 ENOG4108JJA ABC, transporter AW19_1577 ENOG4105CI1 PTS System AW19_1578 ENOG4105F8V Hydrolase, tatD family AW19_1579 ENOG4107QRG dna polymerase iii AW19_158 ENOG41069PW sigma-e factor negative regulatory protein AW19_1580 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AW19_1581 ENOG4105HHA aminodeoxychorismate lyase AW19_1582 ENOG4105YAZ 4-amino-4-deoxychorismate lyase AW19_1583 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AW19_1585 ENOG4105CHR reductase AW19_1586 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AW19_1588 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AW19_1589 ENOG4105VGS 50s ribosomal protein l32 AW19_1590 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AW19_1592 ENOG4105EI2 Pseudouridine synthase AW19_1594 ENOG4107QQB Ribonuclease E AW19_1594 ENOG4107QQB Ribonuclease E AW19_1595 ENOG41067V3 Antibiotic biosynthesis monooxygenase AW19_1596 ENOG4105EKE dihydroorotase AW19_1598 ENOG4105PVA Biofilm formation regulatory protein BssS AW19_16 ENOG4105DKT Transcriptional regulator AW19_160 ENOG4105WMJ Positive regulator of sigma E, RseC MucC AW19_1602 ENOG4105DSF transport protein AW19_1605 ENOG4105D1S lipid A biosynthesis AW19_1607 ENOG4108VGI doxx family AW19_1608 ENOG4105C6X Major Facilitator AW19_1609 ENOG4105DUX Transporter AW19_1612 ENOG4105NAC (LipO)protein AW19_1613 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) AW19_1614 ENOG4105DJ9 glucan biosynthesis protein AW19_1617 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) AW19_162 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AW19_1620 ENOG4108W0S formate-dependent nitrite reductase complex AW19_1621 ENOG4108DMF Cytochrome C biogenesis protein AW19_1622 ENOG4107QX9 Thiol disulfide interChange protein AW19_1623 ENOG4105DA4 cytochrome c-type biogenesis protein AW19_1624 ENOG4105DVI reductase, NrfD AW19_1625 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AW19_1626 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit AW19_1627 ENOG4105EAU Plays a role in nitrite reduction (By similarity) AW19_163 ENOG4105C3F Signal peptidase i AW19_1631 ENOG4105M6W Crispr-associated protein, Csy3 family AW19_1632 ENOG4105DZX CRISPR-associated protein, Csy2 family AW19_1633 ENOG4105ENG CRISPR-associated protein, Csy1 family AW19_1635 ENOG4107IIZ CRISPR-associated helicase, Cas3 AW19_1636 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) AW19_1638 ENOG4108Z0T Part of a sulfur-relay system (By similarity) AW19_1639 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AW19_1641 ENOG4105DR4 Methyltransferase AW19_1642 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) AW19_1643 ENOG4105K4P CoA-binding domain protein AW19_1644 ENOG4108Q67 UPF0319 protein AW19_1647 ENOG41088T4 Helicase IV AW19_1648 ENOG410901E Membrane AW19_1649 ENOG4105EM2 membrane AW19_165 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AW19_1651 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) AW19_1652 ENOG4105UYK outer membrane protein a AW19_1653 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) AW19_1654 ENOG4105DAN ATP-dependent protease AW19_1655 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) AW19_1657 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AW19_1658 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) AW19_1659 ENOG4108Q2G (LipO)protein AW19_166 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AW19_1660 ENOG4105DY2 Paraquat-inducible protein b AW19_1661 ENOG4105F1S paraquat-inducible protein a AW19_1662 ENOG4105C5H ABC transporter AW19_1663 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AW19_1664 ENOG4105QVC MOSC domain-containing protein AW19_1665 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) AW19_1666 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AW19_1667 ENOG4105CD8 aminopeptidase N AW19_1668 ENOG4107RH7 Nicotinate phosphoribosyltransferase AW19_1669 ENOG4105C5S asparaginyl-tRNA synthetase AW19_167 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AW19_1671 ENOG4105CGF Aromatic amino acid aminotransferase AW19_1672 ENOG4105BZU Histidine kinase AW19_1673 ENOG4105C5X domain protein AW19_1674 ENOG4105EAQ (twin-arginine translocation) pathway signal AW19_1675 ENOG4105DIT ErfK YbiS YcfS YnhG family protein AW19_1676 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) AW19_1677 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) AW19_1678 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) AW19_1679 ENOG4106371 Methyltransferase AW19_168 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AW19_1680 ENOG4107S90 membrAne AW19_1681 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups AW19_1682 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AW19_1683 ENOG4105W49 UPF0434 protein AW19_1684 ENOG4105VEQ Cold shock protein AW19_1685 ENOG4105E32 cytoplasmic protein AW19_1686 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AW19_1688 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 AW19_169 ENOG4107EFN gluconate transport system permease 3 AW19_1691 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AW19_1692 ENOG4105CAT Cytidine monophosphate kinase AW19_1693 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AW19_1695 ENOG4107VMU Membrane AW19_1696 ENOG4105HDK L-asparaginase AW19_1697 ENOG4105DDY UPF0142 protein ycaO AW19_1698 ENOG4105TMB Formate nitrite transporter AW19_1699 ENOG4105C6N Formate acetyltransferase AW19_170 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AW19_1700 ENOG4105F1A Pyruvate formate-lyase AW19_1701 ENOG4108ISG Major Facilitator AW19_1702 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AW19_1703 ENOG4105D1H recombination factor protein RarA AW19_1704 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AW19_1705 ENOG4105CNU cell division protein FtsK AW19_1706 ENOG4105EW9 transcriptional regulator AsnC family AW19_1708 ENOG4105C3M thioredoxin reductase AW19_171 ENOG4106G6Q Transcriptional regulator AW19_1710 ENOG4108JJ9 ABC, transporter AW19_1711 ENOG4108JJ8 (ABC) transporter AW19_1712 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AW19_1713 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AW19_1714 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AW19_1715 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AW19_1716 ENOG4105VEQ Cold shock protein AW19_1718 ENOG4105DJY efflux transporter, rnd family, mfp subunit AW19_1719 ENOG4108MJ5 VirK protein AW19_1720 ENOG4105CPB ATP-dependent endonuclease of the OLD family AW19_1721 ENOG4105DWU Membrane AW19_1722 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AW19_1723 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AW19_1724 ENOG4105C7K acetolactate synthase AW19_1726 ENOG4105C5W Aldolase AW19_1727 ENOG4105CGD Nad-dependent epimerase dehydratase AW19_1728 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AW19_1729 ENOG41064MM (LipO)protein AW19_1730 ENOG4105E5Z arginine transporter ATP-binding subunit AW19_1731 ENOG4106PMH Extracellular solute-binding protein family 3 AW19_1732 ENOG4105GBT ABC transporter AW19_1733 ENOG4105DMR ABC, transporter AW19_1734 ENOG4106TNF Periplasmic binding protein AW19_1735 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) AW19_1736 ENOG4105RBQ inner membrane protein ybjO AW19_1737 ENOG4105D38 putrescine abc transporter AW19_1738 ENOG4105F38 ABC transporter, permease AW19_1739 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW19_1740 ENOG4107RUE extracellular solute-binding protein family 1 AW19_1741 ENOG4108RMJ sensory transduction regulator AW19_1742 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress AW19_1743 ENOG41090BQ Glutaredoxin AW19_1744 ENOG4105D0C transport protein AW19_1746 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AW19_1747 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AW19_1748 ENOG4107FB0 transcriptional regulator DeoR family AW19_1749 ENOG4105C44 Serine transporter AW19_175 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB AW19_1750 ENOG4105EJQ L-serine dehydratase AW19_1751 ENOG4105DZ1 carboxypeptidase AW19_1753 ENOG4105C28 cystathionine AW19_1756 ENOG4108UMI ABC transporter, permease AW19_1758 ENOG4105D01 (LipO)protein AW19_1762 ENOG4108TGY Glutathione S-transferase AW19_1763 ENOG4105D05 Receptor AW19_1764 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) AW19_1765 ENOG4108IQI permease AW19_1766 ENOG4105DUM transcriptional regulator, lysR family AW19_177 ENOG4108Z6B deaminase AW19_1770 ENOG4105HMI Membrane AW19_1771 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AW19_1772 ENOG4105DM4 PTS System AW19_1773 ENOG4105DE4 1-phosphofructokinase AW19_1774 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein AW19_1776 ENOG4105KRS Proteinase inhibitor AW19_1777 ENOG4108J2R molybdopterin oxidoreductase AW19_1779 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AW19_178 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AW19_1780 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) AW19_1781 ENOG4105DEI Mannitol dehydrogenase AW19_1782 ENOG4107YCY Transcriptional regulator AW19_1784 ENOG4105CKI cobalamin synthesis protein AW19_1785 ENOG4107TT5 NLP P60 protein AW19_1786 ENOG4105CXC rtn protein AW19_1787 ENOG4105E43 Extracellular solute-binding protein, family 5 AW19_1788 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AW19_1789 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AW19_1790 ENOG4108JQ5 ABC transporter AW19_1791 ENOG4105HG6 AW19_1792 ENOG4105C2C drug resistance transporter, Bcr CflA AW19_1793 ENOG4105I08 Pseudouridine synthase AW19_1794 ENOG4105CFI type iii restriction protein res subunit AW19_1796 ENOG4106V8H Nucleoid-associated protein AW19_1797 ENOG4105PAN UPF0352 protein AW19_1798 ENOG4105E68 Sulfatase AW19_1800 ENOG4105CS2 ec 3.2.1.21 AW19_1801 ENOG4105C5Y PTS System AW19_1802 ENOG4105HX0 Transcriptional regulator AW19_1804 ENOG4105Y50 Virulence Protein AW19_1806 ENOG4105C8Q Methyl-accepting chemotaxis AW19_1808 ENOG4105CT4 transporter AW19_1809 ENOG4107R6D beta-lactam binding protein AmpH AW19_181 ENOG4107WP9 Histidine kinase AW19_1813 ENOG4107QZV Type I secretion membrane fusion protein AW19_1814 ENOG4105BZ1 (ABC) transporter AW19_1817 ENOG4106UW1 Major Facilitator superfamily AW19_1818 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC AW19_1819 ENOG41068CG regulatoR AW19_182 ENOG4108SKK alpha helix protein AW19_1820 ENOG4105BZU Histidine kinase AW19_1821 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW19_1822 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AW19_1823 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW19_1824 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW19_1825 ENOG4105XPH Ferredoxin AW19_1826 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) AW19_1828 ENOG4105E0U tyrosine-specific transport protein AW19_1829 ENOG4108UII YfaZ family AW19_183 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AW19_1830 ENOG4105CH6 catalase AW19_1831 ENOG4105CEY Amp-dependent synthetase and ligase AW19_1832 ENOG4105DNI Converts SHCHC to OSB (By similarity) AW19_1833 ENOG4108IPT Naphthoate synthase AW19_1834 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AW19_1835 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AW19_1836 ENOG4105E4F Isochorismate synthase AW19_1838 ENOG4105TNS Conserved Protein AW19_1839 ENOG4105C01 Dihydroxy-acid dehydratase AW19_184 ENOG4105C4K Nad synthetase AW19_1840 ENOG41090KN UPF0303 protein AW19_1842 ENOG4105C5I Dehydrogenase AW19_1843 ENOG4105K2J Transcriptional regulator AW19_1844 ENOG4105CHR reductase AW19_1845 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AW19_1846 ENOG4108R66 Conserved Protein AW19_1847 ENOG4108UQ5 membrane protein YcdZ AW19_1849 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW19_185 ENOG4108YZA Nitrogen regulatory protein pii AW19_1850 ENOG4105C8S subunit m AW19_1851 ENOG4105D65 subunit l AW19_1852 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW19_1853 ENOG4107UFS subunit j AW19_1854 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW19_1855 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AW19_1856 ENOG4108IEH NADH dehydrogenase subunit g AW19_1857 ENOG4107QIZ NADH dehydrogenase AW19_1858 ENOG4105GKE subunit e AW19_1859 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW19_186 ENOG4105RMW regulation of transcription, DNA-dependent AW19_1860 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW19_1862 ENOG4107NQ8 LysR family Transcriptional regulator AW19_1863 ENOG4105CHM Aminotransferase AW19_1865 ENOG4105DK2 UPF0207 protein AW19_1866 ENOG4107QWE )-transporter AW19_1868 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 AW19_1869 ENOG4105XWI UPF0304 protein AW19_187 ENOG4108M21 AW19_1870 ENOG4105PQ6 UPF0208 membrane protein AW19_1872 ENOG4105C6K Malic enzyme AW19_1873 ENOG4107P2S Transcriptional regulator AW19_1876 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC AW19_1877 ENOG4105PTV Nudix Hydrolase AW19_1878 ENOG4108RE9 Phosphodiesterase AW19_188 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AW19_1880 ENOG4105ECP epimerase AW19_1881 ENOG4108JEH abc transporter atp-binding protein AW19_1882 ENOG4106YG3 ABC transporter AW19_1883 ENOG4105DSP amino acid AbC transporter AW19_1884 ENOG4105E89 ABC transporter AW19_1885 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AW19_1886 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AW19_1887 ENOG4105E96 Colicin v production protein AW19_1888 ENOG4108S3P Sporulation domain protein AW19_189 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AW19_1890 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AW19_1893 ENOG4105DQR SNARE associated Golgi AW19_1896 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AW19_1897 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) AW19_1898 ENOG4108NKV transcriptional regulator AW19_1899 ENOG410631K Membrane AW19_190 ENOG4108MN2 Stationary phase inducible protein CsiE AW19_1901 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW19_1902 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW19_1904 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AW19_1905 ENOG4106WZ1 flagella biosynthesis regulator AW19_1906 ENOG4105F4P )-transporter AW19_1907 ENOG4105D6F Phosphatase AW19_1908 ENOG4105ETE Transcriptional regulator (LacI family AW19_191 ENOG4105D8G Major Facilitator superfamily AW19_1910 ENOG4105CK1 PTS System AW19_1911 ENOG4105CS2 ec 3.2.1.21 AW19_1912 ENOG4105VCP PTS System AW19_1915 ENOG4105BZU Histidine kinase AW19_1916 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AW19_1917 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AW19_1918 ENOG4105MH2 YfcL protein AW19_1919 ENOG4108BPE -transporting atpase AW19_192 ENOG41065CD Exported protein AW19_1920 ENOG4105EJ9 Membrane AW19_1921 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) AW19_1922 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AW19_1923 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AW19_1924 ENOG4108DG9 Smr protein MutS2 AW19_1925 ENOG4108BY2 phosphohistidine phosphatase AW19_1926 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AW19_1927 ENOG4105CHU acetyl-coa acetyltransferase AW19_1928 ENOG4105KZW UPF0381 protein AW19_1929 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AW19_193 ENOG4105D7X high-affinity nickel-transporter AW19_1930 ENOG410903C (LipO)protein AW19_1931 ENOG4105KWW Biogenesis protein AW19_1932 ENOG4105KWW Biogenesis protein AW19_1933 ENOG4107QX9 Thiol disulfide interChange protein AW19_1934 ENOG4105DA4 cytochrome c-type biogenesis protein AW19_1935 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AW19_1936 ENOG4105X3C heme exporter protein AW19_1937 ENOG41060IM Heme exporter protein AW19_1938 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AW19_1940 ENOG4105S64 Formate nitrite transporter AW19_1942 ENOG4105DFP Integrase AW19_195 ENOG4105CVS RNA methyltransferase TrmH family, group 1 AW19_196 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AW19_197 ENOG4105C3J Cysteine desulfurase AW19_1974 ENOG41061CV Terminase small subunit AW19_1979 ENOG4105KUS lysozyme AW19_198 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AW19_1984 ENOG4105RWQ Protein of unknown function (DUF1364) AW19_1992 ENOG4105CDU Replicative dna helicase AW19_2009 ENOG4108PNI recT protein AW19_201 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) AW19_202 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AW19_2021 ENOG4108KU3 Integrase AW19_2023 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AW19_2024 ENOG4105WQ3 Rna-binding protein AW19_2025 ENOG4105C8N cysteinyl-tRNA synthetase AW19_2026 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AW19_2027 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AW19_2028 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AW19_2029 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AW19_203 ENOG4108ZIT Ferredoxin, 2FE-2S AW19_2030 ENOG4105CV6 ABC transporter, permease AW19_2031 ENOG4108I0Y (ABC) transporter AW19_2032 ENOG4108UJV acyl-CoA thioesterase i AW19_2033 ENOG4105E1F short-chain dehydrogenase reductase AW19_2034 ENOG4107QR8 Thioredoxin AW19_2035 ENOG4107QX8 SPFH domain, Band 7 family protein AW19_2036 ENOG4105G5H Membrane AW19_2037 ENOG4108Z6Z Transcriptional regulator AW19_2038 ENOG4105C59 p-type ATPase AW19_2039 ENOG4105MBR gumn family AW19_204 ENOG4105WVQ Fe-S assembly protein IscX AW19_2040 ENOG4108Z66 YbaK ebsC protein AW19_2041 ENOG4105CGH 5'-nucleotidase AW19_2042 ENOG4105EU0 Major facilitator Superfamily AW19_2043 ENOG4105CKD glutathione-regulated potassium-efflux system protein AW19_2044 ENOG4107RE1 Inosine-guanosine kinase AW19_2045 ENOG4105CMR udp-glucose 4-epimerase AW19_2048 ENOG4105ESV Glycosyl transferase, family 4 AW19_2049 ENOG4107RJ7 Glycosyl transferase (Group 1 AW19_2050 ENOG4105CG5 Glycosyl transferase (Group 1 AW19_2051 ENOG4108SHN Glycosyl transferase, family 2 AW19_2053 ENOG4105ER6 polysaccharide biosynthesis protein AW19_2054 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AW19_2055 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AW19_2056 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AW19_2057 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AW19_2058 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AW19_2059 ENOG4107QMP dna polymerase iii subunits gamma and tau AW19_206 ENOG4105YYA enhanced serine sensitivity protein SseB AW19_2060 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AW19_2061 ENOG4105WD1 Membrane AW19_2063 ENOG4105EGS Mechanosensitive ion channel AW19_2064 ENOG41090EX DsrE family AW19_2065 ENOG4108IG5 Transcriptional regulator AW19_2066 ENOG4105C1P efflux transporter, rnd family, mfp subunit AW19_2067 ENOG4105BZS acriflavin resistance protein AW19_2069 ENOG4108626 Racemase AW19_207 ENOG4108MGN ATP-binding component of a transport system AW19_2070 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AW19_2071 ENOG4105MUZ Protein of unknown function DUF2620 AW19_2073 ENOG4105NRA 50s ribosomal protein l31 type b AW19_2074 ENOG4105YK5 50S ribosomal protein L36 AW19_2075 ENOG4105DSE periplasmic solute binding protein AW19_2076 ENOG4105CC5 ABC transporter AW19_2077 ENOG4105DIK (ABC) transporter AW19_2079 ENOG4108UKR Biofilm formation regulator YbaJ AW19_208 ENOG4105DN3 alpha-2-macroglobulin domain protein AW19_2080 ENOG4105KF5 hemolysin expression-modulating protein AW19_2081 ENOG41080UX Methyltransferase AW19_2082 ENOG4108MNP Glycoprotein polysaccharide metabolism AW19_2083 ENOG4105C29 acyl-CoA thioesterase AW19_2084 ENOG4105BZU Histidine kinase AW19_2085 ENOG4108YZA Nitrogen regulatory protein pii AW19_2086 ENOG4105BZ1 (ABC) transporter AW19_2087 ENOG4105BZ1 (ABC) transporter AW19_2088 ENOG4108XM1 transcriptional regulator AsnC family AW19_209 ENOG4108JQB penicillin-binding protein 1C AW19_2090 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) AW19_2091 ENOG4108NFA extracellular solute-binding protein AW19_2092 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AW19_2093 ENOG4108TGP Thioesterase superfamily protein AW19_2094 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein AW19_2095 ENOG4105EIN peptidylprolyl cis-trans isomerase AW19_2097 ENOG4105K70 DNA-binding protein AW19_2098 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AW19_2099 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AW19_21 ENOG4108IV0 ABC, transporter AW19_2101 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AW19_2102 ENOG4105M85 Bola protein AW19_2103 ENOG4105IEY (LipO)protein AW19_2104 ENOG4105EYM Major Facilitator superfamily AW19_2105 ENOG4108NFH Sugar hydrolase AW19_2106 ENOG4105E2S oxidase) subunit II AW19_2107 ENOG4105BZ9 Cytochrome C oxidase, subunit I AW19_2108 ENOG4105CCU oxidase (Subunit III) AW19_2109 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) AW19_2110 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AW19_2111 ENOG4107RDB Major Facilitator AW19_2112 ENOG4108VPT UPF0234 protein AW19_2113 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AW19_2114 ENOG4107S0N DJ-1 family AW19_2115 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AW19_2116 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AW19_2117 ENOG4105CTB Polyprenyl synthetase AW19_2118 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AW19_2119 ENOG4108ZAI phosphatidylglycerophosphatase a AW19_212 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AW19_2120 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AW19_2121 ENOG4107YIM Involved in the transcription termination process (By similarity) AW19_2122 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AW19_2123 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AW19_2126 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AW19_2127 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AW19_2128 ENOG4105VIE preprotein translocase, subunit YajC AW19_2129 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AW19_2133 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AW19_2134 ENOG4108ZYK Acyl carrier protein phosphodiesterase AW19_2135 ENOG4105D3R alkyl hydroperoxide reductase AW19_2137 ENOG4105CHR reductase AW19_2138 ENOG4107R28 alpha amylase, catalytic region AW19_2139 ENOG4105C85 amino acid AW19_2140 ENOG4105CWM branched-chain amino acid transport system II carrier protein AW19_2142 ENOG4105BZU Histidine kinase AW19_2143 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW19_2145 ENOG4107RH8 nuclease SbcCD subunit D AW19_2146 ENOG4105EYH Exonuclease AW19_2147 ENOG4105DKQ ROK family AW19_2148 ENOG4105DH7 May be involved in recombination (By similarity) AW19_2149 ENOG4105NBK UPF0345 protein AW19_2150 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AW19_2157 ENOG4105F2W methyltransferase AW19_216 ENOG4105CUT histidyl-tRNA synthetase AW19_2160 ENOG4105E2V Glycosyltransferase 36 AW19_2162 ENOG4105F8D glycoside hydrolase family 4 AW19_2163 ENOG4105CI1 PTS System AW19_2164 ENOG4105FDP GntR family transcriptional regulator AW19_2165 ENOG4105D9N nucleoside AW19_2166 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) AW19_2167 ENOG4105DD7 kinase (PfkB family AW19_2168 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AW19_217 ENOG4105N21 Membrane AW19_2170 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AW19_2171 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) AW19_2172 ENOG4105V1F Fermentation respiration switch protein AW19_2173 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AW19_2175 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase AW19_2177 ENOG4105CG5 Glycosyl transferase (Group 1 AW19_2178 ENOG4107STW synthase AW19_218 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AW19_2183 ENOG4105C5E polysaccharide biosynthesis protein AW19_2185 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AW19_2187 ENOG4108QY5 Ferric enterobactin transport protein AW19_2188 ENOG4105CIN aminoacyl-histidine dipeptidase AW19_2189 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW19_219 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AW19_2192 ENOG4105WWK YheO domain protein AW19_2193 ENOG4105CPF Cell wall formation (By similarity) AW19_2197 ENOG4105CJ2 (LipO)protein AW19_2198 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) AW19_2199 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AW19_22 ENOG4108IUZ ABC transporter AW19_2200 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AW19_2201 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AW19_2202 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AW19_2203 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AW19_2204 ENOG4105E7A Glutamine amidotransferase AW19_2205 ENOG4105F7V ErfK ybiS ycfS ynhG family protein AW19_2206 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AW19_2207 ENOG4107QPN acyl-Coa dehydrogenase AW19_2208 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AW19_2209 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AW19_221 ENOG4105VPD cellular component movement AW19_2210 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AW19_2211 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) AW19_2212 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AW19_2213 ENOG4105CHM Aminotransferase AW19_2215 ENOG4105EQ0 Major Facilitator superfamily AW19_2216 ENOG4108UMN azlc family AW19_2217 ENOG4105ZED uncharacterized protein ygaH AW19_2218 ENOG4105NTK Transcriptional repressor Mpra AW19_2219 ENOG4105CW7 secretion protein, HlyD family AW19_222 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AW19_2220 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW19_2221 ENOG4105EIB trna rrna methyltransferase AW19_2222 ENOG4105K63 Thioredoxin AW19_2223 ENOG4106IUH DTW domain containing protein AW19_2224 ENOG4105CD5 CoA-binding domain protein AW19_2225 ENOG4105JIM Phosphatidylserine synthase AW19_2226 ENOG4105T42 (LipO)protein AW19_223 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AW19_2232 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AW19_2234 ENOG4108UMI ABC transporter, permease AW19_2235 ENOG4105D01 (LipO)protein AW19_2236 ENOG4108R8X outer membrane lipoprotein AW19_2237 ENOG4108R96 Methyltransferase, YaeB family AW19_2238 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AW19_2239 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion AW19_224 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AW19_2240 ENOG4108YZN class I peptide chain release factor AW19_2241 ENOG4108VWS Yaeq family AW19_2243 ENOG4105M1T rho-binding antiterminator AW19_2245 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AW19_2246 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AW19_225 ENOG4105DFP Integrase AW19_2250 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AW19_2251 ENOG4105C0B DNA polymerase III (alpha subunit) AW19_2252 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AW19_2253 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AW19_2254 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AW19_2255 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AW19_2256 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AW19_2257 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) AW19_2259 ENOG4105DZP Membrane-associated zinc metalloprotease AW19_2260 ENOG4105KNE Phosphatidate cytidylyltransferase AW19_2261 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AW19_2262 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AW19_2263 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AW19_2264 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AW19_2265 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AW19_2266 ENOG4105CE9 30S ribosomal protein S2 AW19_2267 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AW19_2268 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AW19_2269 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) AW19_2270 ENOG4108T8E UPF0325 protein AW19_2271 ENOG4105QDK Flavodoxin AW19_2272 ENOG4105DR9 pseudouridine synthase AW19_2273 ENOG4105WP7 tRNA pseudouridine synthase C AW19_2274 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) AW19_2275 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AW19_2276 ENOG4105EWT decarboxylase family AW19_2277 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease AW19_2278 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) AW19_2279 ENOG4105M08 Membrane AW19_2280 ENOG4105ETT transcriptional Regulator, LysR family AW19_2281 ENOG4105M5B (LipO)protein AW19_2282 ENOG4105C9B Cysteine desulfurase AW19_2283 ENOG4105CUZ uba thif-type nad fad binding protein AW19_2284 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AW19_2285 ENOG4105CA3 membrane-bound lytic murein transglycosylase AW19_2289 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AW19_2290 ENOG4107QZM n-acetylglutamate synthase AW19_2291 ENOG4107QYX exodeoxyribonuclease v alpha AW19_2292 ENOG4107QKA exodeoxyribonuclease V beta AW19_2293 ENOG4107QXK peptidase AW19_2294 ENOG4105DSY exodeoxyribonuclease V, gamma AW19_2295 ENOG4105RVB Prepilin peptidase dependent protein c AW19_2299 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AW19_23 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AW19_2300 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AW19_2301 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AW19_2302 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AW19_2303 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) AW19_2304 ENOG4105EE5 Membrane protein terC AW19_2305 ENOG4105CPC Aldo Keto reductase AW19_2306 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) AW19_2307 ENOG4105CEY Amp-dependent synthetase and ligase AW19_2309 ENOG41060NJ transcriptional regulator AW19_2310 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AW19_2311 ENOG4105RQF LysR family Transcriptional regulator AW19_2312 ENOG4105F27 Major Facilitator AW19_2313 ENOG4105EJC lysr family transcriptional regulator AW19_2317 ENOG4105C8Q Methyl-accepting chemotaxis AW19_2327 ENOG4108VAU general secretion pathway protein G AW19_2328 ENOG4105D7Q type ii secretion system AW19_2329 ENOG4107QHF type ii secretion system protein e AW19_2333 ENOG4107B2H carbonic anhydrase AW19_2335 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AW19_2337 ENOG4105DVC DnaJ domain protein AW19_2338 ENOG4105CQ4 Transcriptional regulator AW19_2339 ENOG4105DPW Major facilitator superfamily MFS_1 AW19_2342 ENOG4105F7P transcriptional regulator AsnC family AW19_2363 ENOG4105CRK lysyL-tRNA synthetase AW19_2364 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AW19_2365 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AW19_2366 ENOG4105T95 Thiol disulfide interChange protein AW19_2367 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW19_2368 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) AW19_2369 ENOG4105CT7 inner membrane cred family protein AW19_2370 ENOG4105EB3 Histidine kinase AW19_2371 ENOG4105E3W Two component transcriptional regulator (Winged helix family AW19_2373 ENOG4105Y75 tpr repeat protein AW19_2374 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AW19_2375 ENOG4108UT2 hemolysin iii AW19_2377 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AW19_2378 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AW19_2379 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AW19_2380 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AW19_2381 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AW19_2382 ENOG4105D0A hydroxylase AW19_2383 ENOG4107RAQ aminopeptidase AW19_2384 ENOG4105E07 UPF0149 protein AW19_2385 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) AW19_2386 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AW19_2387 ENOG4108JQ1 Dehydrogenase AW19_2388 ENOG4105E66 phosphoriboisomerase A AW19_2389 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AW19_2390 ENOG4105MPN Membrane AW19_2391 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AW19_2392 ENOG4105D64 Mechanosensitive ion channel AW19_2394 ENOG4105D2N Aldolase AW19_2395 ENOG4105BZA Phosphoglycerate kinase AW19_2396 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AW19_2397 ENOG4105CV1 Transketolase (EC 2.2.1.1) AW19_2398 ENOG4108K0D peptidase, M48 AW19_24 ENOG4105C32 Amino acid ABC transporter (Permease) AW19_2400 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) AW19_2401 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AW19_2405 ENOG41080HT Transcriptional regulator, arsr family AW19_2406 ENOG4105GPY SprT protein AW19_2407 ENOG4105RWS endonuclease I AW19_2408 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AW19_2409 ENOG4105D7Z glutathione synthase AW19_2410 ENOG4108UJU UPF0301 protein AW19_2411 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AW19_2412 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) AW19_2414 ENOG4105CZX twitching motility protein AW19_2415 ENOG4105DFA alanine racemase domain protein AW19_2416 ENOG4105II7 pyrroline-5-carboxylate reductase AW19_2417 ENOG4108VIA integral membrane protein AW19_2418 ENOG4105VZ9 UPF0235 protein AW19_2419 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AW19_2420 ENOG4105CSA Coproporphyrinogen iii oxidase AW19_2421 ENOG4105K33 Periplasmic Protein AW19_2422 ENOG4105CSV Glutaminase AW19_2423 ENOG41090ED Protein with unknown function (DUF469) AW19_2424 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AW19_2425 ENOG4105CEN a g-specific adenine glycosylase AW19_2426 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AW19_2427 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division AW19_2429 ENOG4105CXN decarboxylase AW19_2435 ENOG4105CDU Replicative dna helicase AW19_2437 ENOG4105DFP Integrase AW19_244 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AW19_2442 ENOG4105C4R Atp-dependent dna helicase AW19_2446 ENOG4105M5Q UPF0482 protein AW19_2464 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AW19_2472 ENOG4107QK5 Homocysteine s-methyltransferase AW19_2473 ENOG4105MFG Antirestriction protein AW19_2474 ENOG4105W5Q DNA repair protein (RadC AW19_2476 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures AW19_2477 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles AW19_2482 ENOG4105CT4 transporter AW19_2484 ENOG4105ETE Transcriptional regulator (LacI family AW19_2488 ENOG4105EQ2 LysR family Transcriptional regulator AW19_2490 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AW19_2492 ENOG4107Z6I Thiamine biosynthesis protein AW19_2494 ENOG4105DEN Luciferase family AW19_2514 ENOG4105NVB glycoside hydrolase, family 19 AW19_2521 ENOG4105NVB glycoside hydrolase, family 19 AW19_2523 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AW19_2525 ENOG4108ZG0 Ompa motb domain protein AW19_2532 ENOG4108MI0 Resistance protein AW19_2533 ENOG4105J12 Multidrug resistance protein mdtN AW19_2537 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AW19_2538 ENOG4108IPW abc transporter atp-binding protein AW19_2539 ENOG4105CM4 permease protein AW19_2545 ENOG4105ETE Transcriptional regulator (LacI family AW19_2548 ENOG4105EAM Na Pi-cotransporter AW19_2549 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AW19_2550 ENOG4105CFC Transporter AW19_2555 ENOG4105C1P efflux transporter, rnd family, mfp subunit AW19_2558 ENOG4105C8H hydrogenase maturation protein Hypf AW19_2559 ENOG4105C45 hydrogenase expression formation protein (HypE) AW19_2560 ENOG4105CQS hydrogenase expression formation protein HypD AW19_2561 ENOG41082MF Hydrogenase assembly chaperone hypC hupF AW19_2562 ENOG4107RSS Hydrogenase accessory protein HypB AW19_2563 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) AW19_2564 ENOG4108WGS hydrogenase 2-specific chaperone AW19_2565 ENOG4108USZ hydrogenase AW19_2566 ENOG4105DPX Hydrogenase, large subunit AW19_2567 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit AW19_2568 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AW19_2569 ENOG4105E3S small subunit AW19_2570 ENOG4108XTF Outer Membrane Lipoprotein AW19_2572 ENOG4107RD7 Flagellar Motor Protein, MotA AW19_2577 ENOG4105MQ3 flagellar protein FliS AW19_2578 ENOG410804A Flagellar hook-associated 2 domain-containing protein AW19_2579 ENOG4105I03 Flagellin AW19_2580 ENOG4108M3R transcriptional activator CadC AW19_2583 ENOG4105DTJ flagellar hook-associated protein AW19_2586 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AW19_2588 ENOG4105CGA flagellar basal-body rod protein FlgG AW19_2589 ENOG4108KPB Flagellar basal-body rod protein FlgF AW19_2590 ENOG4105BZE flagellar hook protein, FlgE AW19_2591 ENOG4105W00 Flagellar hook capping protein AW19_2592 ENOG4108ZC9 flagellar basal-body rod protein flgc AW19_2593 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AW19_2598 ENOG4108JIR Flagellum-specific ATP synthase AW19_26 ENOG4107GFK fumarate AW19_2601 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AW19_2602 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AW19_2603 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AW19_2605 ENOG4105DD5 Flagellar motor switch protein AW19_2606 ENOG4105CN7 Flagellar biosynthetic protein FliP AW19_2607 ENOG4105VS8 Flagellar biosynthetic protein fliq AW19_2608 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AW19_2609 ENOG4105D00 flagellar biosynthetic protein flhB AW19_2612 ENOG4105EXW epimerase dehydratase AW19_2613 ENOG4105CSP Major Facilitator Superfamily AW19_2614 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AW19_2615 ENOG4105WQI isochorismatase AW19_2616 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AW19_2617 ENOG4105E4F Isochorismate synthase AW19_2618 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein AW19_2619 ENOG4105E0A ABC, transporter AW19_2620 ENOG4105TVJ transport system, permease AW19_2621 ENOG4105DQ5 transport system permease protein AW19_2623 ENOG4105E8G Major facilitator Superfamily AW19_2624 ENOG4105CEY Amp-dependent synthetase and ligase AW19_2627 ENOG4105E0K tonB-dependent siderophore receptor AW19_2631 ENOG4105EP1 Efflux transporter rnd family, mfp subunit AW19_2632 ENOG4108IJF Heavy metal efflux pump, CzcA AW19_2633 ENOG4105CF1 Alkylated DNA repair protein AW19_2648 ENOG4108ZZF transport protein (ExbD) AW19_2649 ENOG4105CWK Biopolymer transport protein, ExbB AW19_2650 ENOG4105C28 cystathionine AW19_2651 ENOG4108K81 inner membrane protein YghB AW19_2652 ENOG4105CF7 AraC family transcriptional regulator AW19_2653 ENOG4108I6A alcohol dehydrogenase AW19_2654 ENOG4105CV8 reductase AW19_2656 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) AW19_2657 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase AW19_2658 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW19_2659 ENOG4105NF4 modulator of drug activity AW19_2660 ENOG4105VRH Antibiotic biosynthesis monooxygenase AW19_2661 ENOG4105HEI LysR family (Transcriptional regulator AW19_2662 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW19_2663 ENOG4105IPS esterase AW19_2664 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AW19_2665 ENOG4108SX3 cytoplasmic protein AW19_2666 ENOG41087AY ADP-Ribose pyrophosphatase AW19_2667 ENOG4105DFG type I secretion outer membrane protein AW19_2668 ENOG4105F1G UPF0441 protein AW19_2669 ENOG4106032 Glutathionylspermidine synthase AW19_2670 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AW19_2671 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AW19_2672 ENOG4105W0Z cytoplasmic protein AW19_2673 ENOG4105DVH amino acid AW19_2674 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AW19_2675 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AW19_2676 ENOG4105I7R Adenylate cyclase AW19_2677 ENOG4106MWK domain protein AW19_2678 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AW19_2679 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AW19_2680 ENOG4107ZVW dihydroneopterin aldolase AW19_2681 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AW19_2682 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AW19_2684 ENOG4105VCC 30S ribosomal protein S21 AW19_2685 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AW19_2686 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW19_2688 ENOG4105EHZ conserved protein UCP016719 AW19_2690 ENOG4105D17 glycoside hydrolase, family 3 domain protein AW19_2691 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) AW19_2692 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AW19_2693 ENOG4105C5Y PTS System AW19_2694 ENOG4105CSV Glutaminase AW19_2695 ENOG4105E5D amino acid AW19_2696 ENOG4105CVK Glutamate decarboxylase AW19_2698 ENOG4108YK4 Acid-resistance membrane protein AW19_27 ENOG4107QY8 reductase AW19_2700 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AW19_2701 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AW19_2703 ENOG4108VKG metal-dependent hydrolase AW19_2704 ENOG4105EE0 oxidoreductase AW19_2705 ENOG4105DU1 integral membrane protein, terc AW19_2706 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) AW19_2707 ENOG4105P66 Membrane AW19_2708 ENOG4105CTX dehydratase AW19_2709 ENOG4107QZW Altronate oxidoreductase AW19_2710 ENOG4105D2H Uronic isomerase AW19_2711 ENOG4105DPW Major facilitator superfamily MFS_1 AW19_2714 ENOG4106W5V Membrane AW19_2717 ENOG4105NE1 Conserved Protein AW19_2718 ENOG41090KG Inner membrane protein YqjE AW19_2719 ENOG4105YJD AW19_2720 ENOG4108VBZ doxx family AW19_2721 ENOG4105CHF Glutathione S-transferase AW19_2722 ENOG4105CWB LysR family transcriptional Regulator AW19_2723 ENOG4108CNN domain protein AW19_2724 ENOG4105DQ4 alcohol dehydrogenase AW19_2725 ENOG4105EMU Dehydrogenase AW19_2727 ENOG4107SET aldo keto reductase AW19_2728 ENOG4105EQ2 LysR family Transcriptional regulator AW19_2737 ENOG4108C33 Resolvase AW19_2744 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AW19_2746 ENOG41082RQ UPF0102 protein AW19_2747 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AW19_2748 ENOG4105W4M Transport-associated protein AW19_2749 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AW19_2750 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain AW19_2751 ENOG4105BZU Histidine kinase AW19_2752 ENOG4105N5T Radical SAM Protein AW19_2753 ENOG4105CBC glutamate synthase AW19_2754 ENOG4105BZ8 glutamate synthase AW19_2756 ENOG4105KB2 stringent starvation protein b AW19_2757 ENOG4107MKT Stringent starvation protein a AW19_2758 ENOG4108UJD 30S ribosomal protein S9 AW19_2759 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AW19_2760 ENOG4105D6Z AFG1 family ATPase AW19_2761 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III AW19_2762 ENOG4105C0H protease AW19_2763 ENOG4105C0H protease AW19_2764 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AW19_2765 ENOG4105VFK BolA family AW19_2766 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane AW19_2767 ENOG4105E3I toluene tolerance AW19_2768 ENOG4107PE3 Mammalian cell entry related domain protein AW19_2769 ENOG4105CY3 ABC transporter, permease AW19_2770 ENOG4105DHJ ABC, transporter AW19_2771 ENOG4105FEU K -dependent Na -Ca exchanger AW19_2772 ENOG4105C2X Arabinose 5-phosphate isomerase AW19_2773 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AW19_2774 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) AW19_2775 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AW19_2776 ENOG4108IUZ ABC transporter AW19_2777 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW19_2778 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AW19_2779 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AW19_2780 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AW19_2781 ENOG41080Z8 PHOSPHOCARRIER protein AW19_2783 ENOG4105CXT aspartate transcarbamylase AW19_2784 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) AW19_2785 ENOG4105KME endoribonuclease L-psp AW19_2786 ENOG4105CG3 alpha amylase, catalytic region AW19_2787 ENOG4105C5Y PTS System AW19_2788 ENOG4105D4X repressor AW19_2789 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AW19_279 ENOG4105DWF phosphomethylpyrimidine kinase AW19_2790 ENOG4105EMD TRANSCRIPTIONal AW19_2791 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AW19_2794 ENOG41069H0 dihydroorotase EC 3.5.2.3 AW19_28 ENOG4105QAX Iron-sulfur AW19_2800 ENOG4105NXH GreA GreB family elongation factor AW19_2801 ENOG4108XVM Cytochrome b(562) AW19_2802 ENOG4105CMS peptidase U62, modulator of DNA gyrase AW19_2803 ENOG4105N42 UPF0307 protein AW19_2804 ENOG4105UNR (Barnase) inhibitor AW19_2807 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) AW19_2808 ENOG4105Y49 secretion protein, HlyD family AW19_281 ENOG4108ZGU inhibitor of vertebrate lysozyme AW19_2810 ENOG4105CR8 Transcriptional regulator AW19_2811 ENOG4105D1U peptidase U62 modulator of DNA gyrase AW19_2813 ENOG4105QD6 exported protein AW19_2814 ENOG4105C03 ribonuclease AW19_2816 ENOG4105VQ7 Rod shape-determining protein MreD AW19_2817 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AW19_2818 ENOG4105DFF Rod shape-determining protein mreb AW19_2819 ENOG41062P1 Diguanylate cyclase phosphodiesterase AW19_2820 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AW19_2822 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) AW19_2823 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AW19_2824 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AW19_2825 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AW19_2826 ENOG4105RG0 Membrane AW19_2827 ENOG4108IA2 Sodium pantothenate symporter AW19_2828 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AW19_2829 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AW19_283 ENOG410804X Transcriptional regulator AW19_2830 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AW19_2831 ENOG4105BZU Histidine kinase AW19_2832 ENOG4108XTF Outer Membrane Lipoprotein AW19_2833 ENOG4105VEQ Cold shock protein AW19_2834 ENOG4105VEQ Cold shock protein AW19_2836 ENOG4107QPK )-transporter AW19_2837 ENOG4105D1S lipid A biosynthesis AW19_284 ENOG4105J92 DNA-binding transcriptional activator GutM AW19_2841 ENOG4105CMU LysR family (Transcriptional regulator AW19_2842 ENOG4105EEQ Na H antiporter AW19_2843 ENOG4105C7N Xanthine uracil vitamin C permease AW19_2849 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW19_285 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase AW19_2850 ENOG4105MSB protein, conserved in bacteria AW19_2851 ENOG4105CGF Aromatic amino acid aminotransferase AW19_2852 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AW19_2853 ENOG4105CDU Replicative dna helicase AW19_2854 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AW19_2856 ENOG4105P4Z Phage shock protein G AW19_2857 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AW19_2858 ENOG4105MYN Zinc uptake regulation protein AW19_2859 ENOG4105VDW Csbd family AW19_286 ENOG4105VI0 Pts system, glucitol sorbitol-specific AW19_2860 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AW19_2861 ENOG41080IJ Diacylglycerol kinase AW19_2862 ENOG4105E55 glycerol-3-phosphate acyltransferase AW19_2863 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AW19_2864 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) AW19_2866 ENOG4107W52 maltose operon periplasmic protein AW19_2869 ENOG4107FKK extracellular solute-binding protein family 1 AW19_287 ENOG4105DZY Pts system, glucitol sorbitol-specific AW19_2870 ENOG4105D56 permease protein AW19_2871 ENOG4105EG2 ABC transporter, permease AW19_2872 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AW19_2875 ENOG4105CFH Aspartokinase AW19_2876 ENOG4105C09 Bile acid AW19_2879 ENOG4105C3R Methionine synthase AW19_288 ENOG410787A Pts system, glucitol sorbitol-specific AW19_2880 ENOG41069M3 Transcriptional regulator AW19_2881 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) AW19_2882 ENOG4108I9X Isocitrate lyase AW19_2883 ENOG4107QP3 malate synthase g AW19_2884 ENOG4105CVG Homoserine O-transsuccinylase AW19_289 ENOG4107TE5 Lipid kinase AW19_2893 ENOG4105DC1 bifunctional purine biosynthesis protein purh AW19_2894 ENOG4105C12 Phosphoribosylglycinamide synthetase AW19_2895 ENOG4108T8B Protein of unknown function (DUF1481) AW19_2897 ENOG4105R2J Conserved Protein AW19_2898 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) AW19_2899 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AW19_29 ENOG4107KGK dmso reductase anchor subunit AW19_290 ENOG4105CFP Peptidase U32 AW19_2900 ENOG4105E09 nadh pyrophosphatase AW19_2901 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor AW19_2902 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AW19_2904 ENOG4105D06 uba thif-type nad fad binding protein AW19_2905 ENOG4105WHD thiamine biosynthesis protein ThiS AW19_2906 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AW19_2907 ENOG4105D41 biosynthesis protein thiH AW19_2909 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AW19_291 ENOG4105KWI UPF0339 protein AW19_2911 ENOG4108VZM 50s ribosomal protein L10 AW19_2912 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AW19_2913 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AW19_2914 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AW19_2915 ENOG4105PM1 preprotein translocase subunit SecE AW19_2916 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AW19_292 ENOG4105E3W Two component transcriptional regulator (Winged helix family AW19_2925 ENOG4105CS9 pantothenic acid kinase AW19_2926 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AW19_293 ENOG4105EB3 Histidine kinase AW19_2932 ENOG4108RR8 protoporphyrinogen oxidase AW19_2933 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AW19_2934 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AW19_2935 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) AW19_2936 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AW19_2937 ENOG4105CHU acetyl-coa acetyltransferase AW19_2938 ENOG4107QK7 reductase AW19_2939 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AW19_294 ENOG4105BZS acriflavin resistance protein AW19_2940 ENOG4105MDZ Transcriptional activator rfaH AW19_2941 ENOG4105D52 delta-aminolevulinic acid dehydratase AW19_2943 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AW19_2944 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AW19_2945 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AW19_2946 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AW19_2947 ENOG4105JC1 sterol-binding domain protein AW19_2948 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AW19_2949 ENOG4105CGY Dna recombination protein AW19_2950 ENOG4108KF1 Membrane AW19_2953 ENOG4108I5U Uridine phosphorylase AW19_2954 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) AW19_2955 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AW19_2956 ENOG4105EMK carboxylate amino acid amine transporter AW19_2957 ENOG4105DZ2 Transcriptional regulator AW19_2958 ENOG4105RK9 auxin efflux carrier AW19_2959 ENOG4107T6V glycerophosphoryl diester phosphodiesterase AW19_296 ENOG4105ENT Efflux transporter rnd family, mfp subunit AW19_2960 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW19_2961 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AW19_2962 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AW19_2963 ENOG4105BZ7 extracellular solute-binding protein family 1 AW19_2970 ENOG4108IV0 ABC, transporter AW19_2971 ENOG4105C0Z ABC transporter AW19_2972 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AW19_2973 ENOG4105C32 Amino acid ABC transporter (Permease) AW19_2974 ENOG4105CP9 extracellular ligand-binding receptor AW19_2975 ENOG4105U59 -acetyltransferase AW19_2978 ENOG4105CRP Part of the ABC transporter FtsEX involved in AW19_2979 ENOG4105CAK Cell division ATP-binding protein ftsE AW19_298 ENOG4105R8A Heat shock protein AW19_2980 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AW19_2981 ENOG4106H78 methyltransferase AW19_2982 ENOG4105MG3 Membrane AW19_2985 ENOG4107FS9 Membrane AW19_2987 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AW19_2988 ENOG4105EX9 Membrane AW19_2989 ENOG4108W1V Lipoprotein AW19_299 ENOG4105BZU Histidine kinase AW19_2990 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AW19_2992 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A AW19_2993 ENOG4105CXY transporter AW19_2994 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AW19_2995 ENOG4105DQF Hydrolase AW19_2996 ENOG4108EUD Lysophospholipase AW19_2998 ENOG4105CCF Lysine exporter protein (Lyse ygga) AW19_2999 ENOG4105C9U ATP-dependent DNA helicase RecQ AW19_30 ENOG4108NEM leader-binding protein dmsD AW19_300 ENOG4105CJW magnesium transporter AW19_3000 ENOG4105HDD phospholipase AW19_3001 ENOG4108VUY thioesterase Superfamily protein AW19_3002 ENOG4105FR1 rard protein AW19_3003 ENOG4107QUT magnesium and cobalt transport protein CorA AW19_3006 ENOG4105EQN UPF0261 protein AW19_3008 ENOG4105C4R Atp-dependent dna helicase AW19_3009 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant AW19_3010 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW19_3011 ENOG4105CT0 Protein of unknown function, DUF484 AW19_3012 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AW19_3013 ENOG4105S7Z (LipO)protein AW19_3014 ENOG4105XQ6 frataxin-like protein AW19_3016 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AW19_3017 ENOG41076E6 Uroporphyrinogen-III Synthase AW19_3018 ENOG4105ECF c-methyltransferase AW19_3019 ENOG410601J HemY protein AW19_302 ENOG4105C9X ppx gppa phosphatase AW19_3026 ENOG4105C85 amino acid AW19_3029 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) AW19_303 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AW19_3030 ENOG4105EGZ biosynthesis protein AW19_3031 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AW19_3032 ENOG4108WJ1 acetyltransferase AW19_3033 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AW19_3034 ENOG4105C1B dTDP-glucose 4-6-dehydratase AW19_3035 ENOG4108IJ1 Dehydrogenase AW19_3036 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AW19_3037 ENOG4105SFE lipopolysaccharide biosynthesis protein AW19_3038 ENOG4105ESV Glycosyl transferase, family 4 AW19_304 ENOG4105C8U phosphate abc transporter AW19_3040 ENOG4105K63 Thioredoxin AW19_3042 ENOG4105C9X ppx gppa phosphatase AW19_3043 ENOG4105C4R Atp-dependent dna helicase AW19_3044 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AW19_3046 ENOG4105GQR Chaperone AW19_3047 ENOG4105CW0 outer membrane usher protein AW19_3049 ENOG4108VEV chaperone AW19_305 ENOG4105E2Z phosphate ABC transporter (Permease AW19_3051 ENOG41060S4 immunity protein AW19_3055 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AW19_3056 ENOG4105EMY transcriptional regulator AW19_3057 ENOG4105C7B Threonine dehydratase AW19_3058 ENOG4105C01 Dihydroxy-acid dehydratase AW19_3059 ENOG4105CM2 brancheD-chain amino acid aminotransferase AW19_3060 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit AW19_3062 ENOG4105C0P Mg chelatase subunit ChlI AW19_3063 ENOG4108WFC UPF0438 protein yifE AW19_3064 ENOG4105CVI Transcriptional regulator AW19_307 ENOG4108C80 FliB family AW19_3072 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AW19_3074 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) AW19_3075 ENOG4108Y73 Membrane AW19_3077 ENOG4105C5Q Transcriptional regulator AW19_3078 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AW19_3079 ENOG4105EHV domain protein AW19_308 ENOG4108MK9 spermidine N(1)-acetyltransferase AW19_3080 ENOG4107QN2 dihydrolipoyl dehydrogenase AW19_3082 ENOG4107QZV Type I secretion membrane fusion protein AW19_3089 ENOG4105CH7 arginosuccinase AW19_309 ENOG4108V3E phosphoribosylglycinamide formyltransferase AW19_3090 ENOG4105CAS nag kinase AW19_3091 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AW19_3093 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AW19_3094 ENOG4105SYT Methylenetetrahydrofolate reductase AW19_3095 ENOG4105CFH Aspartokinase AW19_3096 ENOG4105C28 cystathionine AW19_3097 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) AW19_3098 ENOG4105VFB Binds the 23S rRNA (By similarity) AW19_3099 ENOG4105C25 Primosomal protein n' AW19_310 ENOG4105CXB phosphoribosylaminoimidazole synthetase AW19_3100 ENOG4105ETE Transcriptional regulator (LacI family AW19_3101 ENOG41063M6 Cell Division Protein AW19_3102 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AW19_3103 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AW19_3104 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AW19_3105 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AW19_3106 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) AW19_3107 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AW19_3108 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AW19_3109 ENOG4105CBT Fructose-1,6-bisphosphatase AW19_311 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AW19_3110 ENOG4105E5M Multidrug resistance protein D AW19_3111 ENOG4105DP0 ferredoxin-NADP reductase AW19_3112 ENOG4108VTS Membrane AW19_3113 ENOG4105EBK exported protein AW19_3116 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AW19_3118 ENOG41076HS cation diffusion facilitator family transporter AW19_3119 ENOG4105FMW periplasmic AW19_312 ENOG4105C2W permease AW19_3120 ENOG4105E3W Two component transcriptional regulator (Winged helix family AW19_3121 ENOG4105E0F Histidine kinase AW19_3122 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AW19_3123 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AW19_3124 ENOG4105D7W serine acetyltransferase AW19_3125 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AW19_3127 ENOG4105VW4 glutaredoxin 3 AW19_3128 ENOG4107YZP Rhodanese domain protein AW19_3129 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AW19_313 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) AW19_3130 ENOG41063SB peptidase AW19_3131 ENOG4105PXI polysaccharide deacetylase AW19_3132 ENOG4105CPQ Dehydrogenase AW19_3133 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AW19_3134 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) AW19_3135 ENOG4105XA0 heptosyltransferase ii AW19_3136 ENOG4105D16 lipopolysaccharide heptosyltransferase i AW19_3137 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AW19_314 ENOG4105K89 arsenate reductase AW19_3140 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AW19_3141 ENOG4105W0E 50S ribosomal protein L33 AW19_3142 ENOG4105KDC 50s ribosomal protein l28 AW19_3143 ENOG4105W5Q DNA repair protein (RadC AW19_3144 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AW19_3145 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AW19_3146 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AW19_3148 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW19_315 ENOG4105ERG peptidase m48, ste24p AW19_3158 ENOG4108IRC dna polymerase iii AW19_3159 ENOG4105DFE Dna adenine methylase AW19_316 ENOG4105C02 permease AW19_3162 ENOG4105VZ1 Replication Protein AW19_3166 ENOG4105ED4 portal protein AW19_317 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW19_318 ENOG4105RH4 Glycine cleavage system transcriptional repressor AW19_319 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AW19_3191 ENOG4105ZTC transcriptional activator, Ogr delta AW19_3194 ENOG4105DSJ YicC domain protein AW19_320 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AW19_3200 ENOG4105BZU Histidine kinase AW19_3201 ENOG4105E39 Enoyl-CoA hydratase AW19_3202 ENOG4105D9N nucleoside AW19_3203 ENOG4105D9N nucleoside AW19_3204 ENOG4105EN6 Membrane AW19_3205 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) AW19_3207 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AW19_3208 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AW19_3209 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AW19_321 ENOG4105C8V SAICAR synthetase AW19_3210 ENOG4105CB5 ATP-dependent DNA helicase recG AW19_3211 ENOG4105D6U Sodium Glutamate Symporter AW19_3212 ENOG4105C2W permease AW19_3213 ENOG4105JV1 AsmA family AW19_3215 ENOG4108Q9V regulatoR AW19_3216 ENOG4105HVQ Regulatory factor of maltose metabolism AW19_3217 ENOG4105SUU thioesterase domain AW19_3218 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AW19_3219 ENOG4107S2Z UPF0761 membrane protein AW19_322 ENOG4105CGZ zinc metallopeptidase AW19_3220 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 AW19_3222 ENOG4105C5F glutamine synthetase AW19_3223 ENOG4105CUX Signal transduction histidine kinase AW19_3224 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AW19_3225 ENOG4105D4P Coproporphyrinogen iii oxidase AW19_3226 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) AW19_3227 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AW19_3228 ENOG4105C2M dna polymerase I AW19_3229 ENOG4108Z33 Thiol disulfide Interchange Protein AW19_323 ENOG4108VMM UPF0756 membrane protein AW19_3230 ENOG4105E27 serine threonine protein kinase AW19_3231 ENOG4105PC1 Conserved Protein AW19_3233 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b AW19_324 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) AW19_3240 ENOG4107EJG GntR family transcriptional regulator AW19_3241 ENOG4105ETE Transcriptional regulator (LacI family AW19_3242 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW19_3243 ENOG4108RVA ribokinase AW19_3244 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AW19_3245 ENOG4105CNN ABC, transporter AW19_3247 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) AW19_3249 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) AW19_325 ENOG4106KED esterase YpfH AW19_3250 ENOG4105EV2 VWA domain protein interacting with AAA ATPase AW19_3252 ENOG4105CU9 asparagine synthetase A AW19_3253 ENOG4108VVK transcriptional Regulator, AsnC AW19_3254 ENOG4105QTB Flavodoxin AW19_3255 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AW19_3256 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AW19_3257 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation AW19_3258 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) AW19_3259 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AW19_326 ENOG4105XYK UPF0370 protein AW19_3260 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AW19_3261 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AW19_3262 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AW19_3264 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AW19_3265 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AW19_3266 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AW19_3267 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AW19_3268 ENOG4105CHH sulfate transporter AW19_3269 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AW19_3270 ENOG4105C8U phosphate abc transporter AW19_3271 ENOG4105E2Z phosphate ABC transporter (Permease AW19_3275 ENOG4106PMH Extracellular solute-binding protein family 3 AW19_3276 ENOG4105EAD ABC transporter AW19_3277 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 AW19_3278 ENOG4105DRP amino acid AbC transporter AW19_3279 ENOG4105C7N Xanthine uracil vitamin C permease AW19_328 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AW19_3281 ENOG4108ZXC Two component transcriptional regulator, luxr family AW19_3282 ENOG4105BZU Histidine kinase AW19_3283 ENOG4108YYH Nadph-dependent fmn reductase AW19_3284 ENOG4105C8Q Methyl-accepting chemotaxis AW19_3285 ENOG4108UMI ABC transporter, permease AW19_3288 ENOG4105RKW reductase (By AW19_3289 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AW19_329 ENOG4105KUZ arsenate reductase AW19_3290 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AW19_3292 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AW19_3293 ENOG4105VG0 50S ribosomal protein l34 AW19_3294 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AW19_3295 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AW19_3296 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AW19_3297 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW19_3298 ENOG410667J hydrolase AW19_33 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AW19_3300 ENOG4105C7B Threonine dehydratase AW19_3301 ENOG4108SGR YheO domain-containing protein AW19_3302 ENOG4105D99 atp gtp-binding protein AW19_3303 ENOG4105R2A (LipO)protein AW19_3306 ENOG4105D0C transport protein AW19_3307 ENOG4105JKW Valine--pyruvate aminotransferase AW19_3308 ENOG4107T9C Alpha amylase catalytic region AW19_3309 ENOG4105C5I Dehydrogenase AW19_3314 ENOG4105HNP -acetyltransferase AW19_3315 ENOG4108R3E Dna-3-methyladenine glycosylase i AW19_3318 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AW19_3319 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AW19_3320 ENOG4106JH6 (LipO)protein AW19_3321 ENOG4105CTS PTS system mannitol-specific AW19_3322 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase AW19_3324 ENOG4105E61 Mannitol repressor protein AW19_3325 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW19_3326 ENOG4108YYI Protein of unknown function (DUF2810) AW19_3327 ENOG4105C8Q Methyl-accepting chemotaxis AW19_3328 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW19_3329 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AW19_333 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC AW19_3330 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AW19_3331 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AW19_3332 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AW19_3333 ENOG4108MG3 formate dehydrogenase AW19_3334 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) AW19_3335 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) AW19_3336 ENOG4105EM7 Selenocysteine-specific translation elongation factor AW19_3341 ENOG4105ECQ AraC Family Transcriptional Regulator AW19_3342 ENOG4105MEV Acyl-transferase AW19_3343 ENOG4108RWI nicotinamidase AW19_3344 ENOG4108TTM chaperone AW19_3345 ENOG4105CMG Carbohydrate kinase AW19_3346 ENOG4105C93 Xylose Isomerase AW19_3347 ENOG4105DFW ABC transporter AW19_3349 ENOG4107RNG ABC transporter AW19_335 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW19_3350 ENOG4105T16 Transcriptional regulator (AraC family) AW19_3352 ENOG4105BZU Histidine kinase AW19_3357 ENOG4105CGP Urocanate hydratase AW19_3358 ENOG4105C84 Histidine ammonia-lyase AW19_3359 ENOG4105C85 amino acid AW19_336 ENOG4105BZS acriflavin resistance protein AW19_3362 ENOG4108ZHJ Organic hydroperoxide resistance protein AW19_3363 ENOG4105DIJ Phosphoethanolamine transferase AW19_3364 ENOG4108KX4 response regulator AW19_3365 ENOG4105BZU Histidine kinase AW19_3366 ENOG4105CXY transporter AW19_3370 ENOG4105D5K Hemolysin activator protein AW19_3371 ENOG4105CKT filamentous hemagglutinin AW19_3372 ENOG4105DEF Extracellular solute-binding protein, family 5 AW19_3373 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW19_3374 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW19_3375 ENOG4105C3U ABC transporter AW19_3376 ENOG4108JQ7 (ABC) transporter AW19_3377 ENOG4105D1V cellulose synthase operon protein YhjU AW19_3378 ENOG4105WQA Cellulose biosynthesis protein BcsF AW19_3379 ENOG4105U74 cellulose biosynthesis protein BcsE AW19_338 ENOG4105WH1 Two component transcriptional regulator luxr family AW19_3381 ENOG4105UTS cellulose synthase operon protein YhjQ AW19_3382 ENOG4107QZ7 Cellulose synthase catalytic subunit AW19_3383 ENOG4107EEX Cellulose synthase regulator protein AW19_3384 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) AW19_3385 ENOG4105EJG cellulose synthase AW19_3386 ENOG4105BZU Histidine kinase AW19_3387 ENOG4108PU9 oligogalacturonate-specific porin AW19_3389 ENOG4105CK2 sodium dicarboxylate symporter AW19_3390 ENOG4105CS0 peptidase AW19_3391 ENOG4107SS6 2-dehydro-3-deoxygluconokinase AW19_3392 ENOG4105VSH 4-oxalocrotonate tautomerase AW19_3393 ENOG4105CMB EAL domain-containing protein AW19_3394 ENOG41066T0 asmA family AW19_3395 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) AW19_3396 ENOG4107H3J ribonuclease AW19_3398 ENOG4105DC8 reductase AW19_3399 ENOG4105D6S protein involved in catabolism of external DNA AW19_34 ENOG4105Y3E Modulates RecA activity (By similarity) AW19_340 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase AW19_3400 ENOG4105DGW oligopeptidase A AW19_3401 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) AW19_3405 ENOG4108M6U Universal stress protein A AW19_3406 ENOG4108V6B universal stress protein B AW19_3407 ENOG4105CJ3 phosphate transporter AW19_3408 ENOG4105CBX hi0933 family AW19_341 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AW19_3414 ENOG4105CW0 outer membrane usher protein AW19_3418 ENOG4105C5H ABC transporter AW19_342 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) AW19_3420 ENOG4105C26 Dehydrogenase AW19_3421 ENOG4105DH8 myo-inositol catabolism AW19_3423 ENOG4105D7K pfkb domain protein AW19_3424 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) AW19_3425 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AW19_3426 ENOG4105F0H myo-inositol catabolism protein AW19_3427 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AW19_3428 ENOG4105WCN acetyltransferase AW19_3429 ENOG4105C2I pirin domain protein AW19_343 ENOG4105CUW cytochrome C-TYPE protein AW19_3430 ENOG4105DIQ Transcriptional regulator AW19_3431 ENOG4105C6Z Gluconate AW19_3432 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AW19_3433 ENOG41076UM multiple antibiotic resistance (MarC)-related protein AW19_3434 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AW19_3437 ENOG4107R0E Glycosyl transferase, family 2 AW19_3440 ENOG4108MBX Secretion Protein AW19_3441 ENOG4108JJA ABC, transporter AW19_3442 ENOG4108HRK Histidine kinase AW19_3443 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AW19_3444 ENOG4108IUM Glycogen debranching enzyme AW19_3446 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AW19_3447 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AW19_3448 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AW19_3451 ENOG4105E98 transcriptional regulator DeoR family AW19_3452 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) AW19_3454 ENOG41061ZR Transcriptional regulator AW19_3455 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AW19_3456 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) AW19_3457 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) AW19_3458 ENOG4105MJ2 Competence protein AW19_3459 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AW19_346 ENOG4107VIJ nudix hydrolase AW19_3460 ENOG4105RID UPF0379 protein yhcN AW19_3461 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) AW19_3462 ENOG4105CE1 Ferrous iron transport protein b AW19_3463 ENOG4105XFK Ferrous iron transport protein A AW19_3464 ENOG4105BZM domain protein AW19_3469 ENOG4108RRZ Transcription elongation factor GreB AW19_347 ENOG4105C6K Malic enzyme AW19_3470 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW19_3471 ENOG4105E0F Histidine kinase AW19_3472 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AW19_3474 ENOG4105VEJ Heat shock protein AW19_3475 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 AW19_3476 ENOG4105DQY intracellular growth attenuator AW19_3477 ENOG4107RK2 ADP-ribose diphosphatase NudE AW19_3478 ENOG4108JQC penicillin-binding protein 1A AW19_348 ENOG4108UPT UPF0178 protein AW19_3483 ENOG4105E4G Type IV pilus AW19_3484 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AW19_3488 ENOG4105DJV ribulose-phosphate 3-epimerase AW19_349 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AW19_3490 ENOG4105C31 Tryptophanyl-tRNA synthetase AW19_3491 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW19_3492 ENOG4107V9H nitrite transporter AW19_3493 ENOG4105WZK nitrite reductase NADPH small subunit AW19_3494 ENOG4107QZF nitrite reductase NADPH large subunit AW19_3495 ENOG4105DZC cytosine deaminase AW19_3496 ENOG4106DTQ Protein TsgA homolog AW19_3497 ENOG41060NJ transcriptional regulator AW19_3498 ENOG4105F8D glycoside hydrolase family 4 AW19_3499 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AW19_35 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW19_350 ENOG4108R6G acetyltransferase AW19_3500 ENOG4105D7A ATP-binding protein AW19_3503 ENOG4105C8Y Acetylornithine aminotransferase AW19_3504 ENOG410613R integral membrane protein, YccS YhfK family AW19_3506 ENOG4108UKZ OsmC family AW19_3507 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AW19_3508 ENOG4105YP7 UPF0270 protein AW19_3509 ENOG4105DNZ Alpha Beta Hydrolase AW19_351 ENOG4105H4F exported protein AW19_3511 ENOG4105JAB phenazine biosynthesis protein, phzf family AW19_3512 ENOG4106FTQ Taurine ABC transporter, periplasmic AW19_3514 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AW19_3516 ENOG4105E2B Taurine dioxygenase AW19_3518 ENOG4105C5H ABC transporter AW19_3519 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AW19_352 ENOG4105E7K (LipO)protein AW19_3521 ENOG4105VKU nucleicacid-binding protein AW19_3522 ENOG4108YZY peptidylprolyl cis-trans isomerase AW19_3524 ENOG4108V1T peptidylprolyl cis-trans isomerase AW19_3525 ENOG4105WWK YheO domain protein AW19_3526 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) AW19_3527 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AW19_3528 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AW19_353 ENOG4105EZR dyp-type peroxidase family protein AW19_3530 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AW19_3532 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AW19_3536 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AW19_3538 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AW19_3539 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AW19_3540 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AW19_3541 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AW19_3542 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AW19_3543 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AW19_3544 ENOG41083MP 50s ribosomal protein l29 AW19_3545 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AW19_3547 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AW19_3549 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AW19_3551 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AW19_3552 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AW19_3554 ENOG4105VPB 50S ribosomal protein L30 AW19_3555 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AW19_3556 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AW19_3557 ENOG41067V7 50S ribosomal protein L36 AW19_3558 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AW19_3559 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AW19_3560 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AW19_3561 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AW19_3562 ENOG4108ZT0 50S ribosomal protein l17 AW19_3563 ENOG4105VTS DnaJ-like, subfamily C AW19_3564 ENOG4105W1Y Transcriptional regulator AW19_3565 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system AW19_3566 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AW19_3567 ENOG4105C1A potassium transporter peripheral membrane AW19_3568 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AW19_3569 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AW19_357 ENOG4108R66 Conserved Protein AW19_3570 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AW19_3571 ENOG4105C79 DNA protecting protein DprA AW19_3573 ENOG4108WI1 Dna topoisomerase AW19_3574 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AW19_3575 ENOG4105E2X shikimate dehydrogenase AW19_3576 ENOG4108Z0R Transferase AW19_358 ENOG4105QEK Transcriptional regulator AW19_3583 ENOG4107QN1 sodium solute AW19_3584 ENOG41062QD Membrane AW19_3585 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AW19_3587 ENOG4105CK2 sodium dicarboxylate symporter AW19_3589 ENOG4105BZU Histidine kinase AW19_3595 ENOG4105ZQI secreted protein AW19_3597 ENOG4108SZ7 secretion system effector AW19_36 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AW19_360 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein AW19_3609 ENOG4105UQF type iii secretion AW19_361 ENOG4108I5D sulfate abc transporter AW19_3610 ENOG4106H1D secretion system apparatus protein AW19_3612 ENOG4108JIR Flagellum-specific ATP synthase AW19_3615 ENOG41063Q7 Type III secretion system protein AW19_3616 ENOG4108HHI Type III secretion system protein AW19_3617 ENOG41083GP type iii secretion AW19_3618 ENOG4108TN6 type iii secretion AW19_3619 ENOG4108IUF type iii secretion AW19_362 ENOG4105ECW sulfate abc transporter AW19_3620 ENOG41066VF YeeE YedE family protein AW19_3621 ENOG4105KSU Redox protein AW19_3622 ENOG4105EGS Mechanosensitive ion channel AW19_3623 ENOG4105E0K tonB-dependent siderophore receptor AW19_3625 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW19_3626 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AW19_3627 ENOG4105EHG Permease protein AW19_3628 ENOG4107R4I Periplasmic binding protein AW19_3629 ENOG4106QJH hemin transport protein AW19_3630 ENOG4107ENK receptor AW19_3631 ENOG4107F3C Hemin uptake protein AW19_3634 ENOG4105CDU Replicative dna helicase AW19_364 ENOG4105C6T cysteine synthase AW19_365 ENOG4105E3W Two component transcriptional regulator (Winged helix family AW19_366 ENOG4105E0F Histidine kinase AW19_367 ENOG4105C5Y PTS System AW19_3671 ENOG41085W3 Transposase AW19_3675 ENOG4105F9F transposase AW19_3676 ENOG4105F9F transposase AW19_368 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AW19_3687 ENOG4105VUH addiction module killer protein AW19_369 ENOG4105KZ7 phosphocarrier protein hpr AW19_3697 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures AW19_370 ENOG4105C6T cysteine synthase AW19_3700 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AW19_3701 ENOG4105C4R Atp-dependent dna helicase AW19_3703 ENOG4105F9F transposase AW19_3710 ENOG4108SIC Transcriptional regulator AW19_3711 ENOG4105CNV Aldolase AW19_3712 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AW19_3714 ENOG4105BZW Glycerate kinase AW19_3715 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AW19_3716 ENOG4105CTX dehydratase AW19_3717 ENOG4105DJB Major Facilitator Superfamily AW19_3719 ENOG4105BZ8 glutamate synthase AW19_3720 ENOG4108RC0 Electron transport protein AW19_3721 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AW19_3722 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AW19_3724 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AW19_3727 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AW19_3728 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AW19_3729 ENOG4108ZVF (LipO)protein AW19_373 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AW19_3730 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AW19_3731 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AW19_3733 ENOG4105KPY Small multidrug resistance protein AW19_3735 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AW19_3736 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AW19_3739 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AW19_374 ENOG4105VRT cytoplasmic protein AW19_3740 ENOG4105EGS Mechanosensitive ion channel AW19_3741 ENOG4105DJ4 phosphatidylserine decarboxylase AW19_3742 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AW19_3743 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AW19_3747 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AW19_3748 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AW19_3749 ENOG4105K8N protein family UPF0079, ATPase AW19_3750 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AW19_3751 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AW19_3752 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AW19_3754 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AW19_3755 ENOG4107QJR hflk protein AW19_3756 ENOG4105EPW hflc protein AW19_3758 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AW19_3759 ENOG4105KPV Transcriptional regulator AW19_3760 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AW19_3761 ENOG4105C2N RNA methyltransferase TrmH family group 3 AW19_3762 ENOG4105CSU acyl-Coa dehydrogenase AW19_3763 ENOG4105WSB biofilm stress and motility protein A AW19_3764 ENOG4108MXZ Esterase AW19_3766 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AW19_3767 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) AW19_3768 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AW19_3769 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AW19_3771 ENOG4105FHY Opacity-associated protein A AW19_3772 ENOG4108V1T peptidylprolyl cis-trans isomerase AW19_3774 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AW19_3775 ENOG4108UUE Transcriptional regulator AW19_3776 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase AW19_3777 ENOG41061GZ Protein of unknown function (DUF1107) AW19_3778 ENOG4105C37 (CBS) domain AW19_3779 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AW19_3780 ENOG4105CFU surface antigen AW19_3781 ENOG4105MA0 exported protein AW19_3782 ENOG4108ZHD aig2 family AW19_3783 ENOG4105F0N pyrophosphate phospho-hydrolase AW19_3784 ENOG4105C8Q Methyl-accepting chemotaxis AW19_3785 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AW19_3786 ENOG4105DFU Cell wall formation (By similarity) AW19_3788 ENOG4105VR4 UPF0379 protein ybiJ AW19_3789 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) AW19_3790 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AW19_3791 ENOG4105HVQ Regulatory factor of maltose metabolism AW19_3793 ENOG4105EAH synthase AW19_3796 ENOG4105QYV Membrane AW19_3797 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AW19_380 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AW19_3800 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase AW19_3801 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AW19_3802 ENOG4105HBR Rna-binding protein AW19_3803 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AW19_3804 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AW19_3805 ENOG4105EEI dihydropteroate synthase AW19_3810 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AW19_3811 ENOG4105CHV Transcription elongation factor NusA AW19_3812 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AW19_3813 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AW19_3814 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AW19_3816 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AW19_3818 ENOG4105C1J atp-dependent rna helicase AW19_3819 ENOG4105DEN Luciferase family AW19_3820 ENOG4106RZ4 Peptidase U32 AW19_3821 ENOG4105CFP Peptidase U32 AW19_3822 ENOG4105XPQ lipid carrier protein AW19_3823 ENOG41082IR Excinuclease ABC C subunit domain protein AW19_3824 ENOG4108YYD acetyltransferase AW19_3825 ENOG4105D5Q Arginine ornithine antiporter AW19_3826 ENOG4105CXN decarboxylase AW19_3830 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component AW19_3831 ENOG4105DRS transport system, permease AW19_3834 ENOG4108ZPB UPF0306 protein AW19_3835 ENOG4105K4T epimerase AW19_3836 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein AW19_3837 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) AW19_3838 ENOG4105FD8 phosphonate metabolism protein PhnM AW19_3839 ENOG4105HRV phosphonate c-p lyase system protein phnl AW19_384 ENOG4105D9N nucleoside AW19_3840 ENOG4105ENV phosphonate C-P lyase system protein PhnK AW19_3841 ENOG4105FT8 Phosphonate metabolism AW19_3842 ENOG4105EKV Phosphonate metabolism protein AW19_3843 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH AW19_3844 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG AW19_3845 ENOG4107RJJ Transcriptional regulator AW19_3846 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AW19_3847 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AW19_3848 ENOG4108JQ7 (ABC) transporter AW19_3849 ENOG4105C3U ABC transporter AW19_3850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW19_3851 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW19_3853 ENOG4105XEP YhcH YjgK YiaL family protein AW19_3855 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) AW19_3856 ENOG4108MJ3 acetyltransferase AW19_3858 ENOG4105MYG DNA polymerase iii, chi subunit AW19_3859 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AW19_3860 ENOG4108M8S permease YjgP YjgQ family protein AW19_3861 ENOG4108K5H permease YjgP YjgQ family protein AW19_3865 ENOG4105CVR type I restriction-modification system AW19_3870 ENOG4105CKT filamentous hemagglutinin AW19_3873 ENOG4105CKT filamentous hemagglutinin AW19_3874 ENOG4105D5K Hemolysin activator protein AW19_388 ENOG4105CPC Aldo Keto reductase AW19_3881 ENOG4105RI1 glycoprotein receptor AW19_3882 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound AW19_3883 ENOG41061GT Aldolase AW19_3884 ENOG4105D4B ABC, transporter AW19_3885 ENOG4105F5R ABC transporter AW19_3886 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AW19_3887 ENOG4105C2J ABC transporter AW19_3888 ENOG4105DKT Transcriptional regulator AW19_3889 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AW19_389 ENOG4105DUM transcriptional regulator, lysR family AW19_3890 ENOG4105DKP glycosyl transferase, family 9 AW19_3892 ENOG4105D5Q Arginine ornithine antiporter AW19_3893 ENOG4105CEU Arginine dihydrolase AW19_3894 ENOG410624X efflux transporter, rnd family, mfp subunit AW19_3895 ENOG4105BZS acriflavin resistance protein AW19_3897 ENOG4105CMT Dihydroxyacetone kinase AW19_3898 ENOG4108UTZ Dihydroxyacetone kinase AW19_3899 ENOG4105VDH Dihydroxyacetone kinase AW19_3907 ENOG4105BZU Histidine kinase AW19_3908 ENOG4105YBH Protein of unknown function (DUF1435) AW19_391 ENOG4105CHC glucokinase (EC 2.7.1.2) AW19_3911 ENOG4105CBN LysR family transcriptional regulator AW19_3912 ENOG4105CPC Aldo Keto reductase AW19_3913 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AW19_3914 ENOG4108WPU DNA polymerase III subunit psi AW19_3915 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AW19_3916 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AW19_3917 ENOG4105K3G Periplasmic Protein AW19_3919 ENOG4108NRW Phospholipase, patatin family AW19_392 ENOG4105FCD Major Facilitator AW19_3920 ENOG4105EYA deoxyribonuclease AW19_3921 ENOG4105D9N nucleoside AW19_3922 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AW19_3923 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AW19_3924 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AW19_3926 ENOG41062Z9 Membrane AW19_3927 ENOG4105EAC phosphoserine phosphatase AW19_3928 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AW19_393 ENOG4105DY9 regulatoR AW19_3930 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase AW19_3931 ENOG4105CIS alcohol dehydrogenase AW19_3933 ENOG4105C5H ABC transporter AW19_3935 ENOG4107SC1 transglycosylase AW19_3936 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) AW19_3937 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AW19_3938 ENOG4105UEI Transcriptional Regulator AraC Family AW19_394 ENOG4108HRK Histidine kinase AW19_3940 ENOG4108RH0 Crea protein AW19_3941 ENOG41065U4 response regulator AW19_3943 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AW19_3945 ENOG4105D1Q UPF0246 protein AW19_3946 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AW19_3947 ENOG4108RIR Molybdenum cofactor biosynthesis protein AW19_3948 ENOG4105CSH Transporter AW19_395 ENOG41072TH Protein of unknown function (DUF1479) AW19_3951 ENOG4106HK8 GPR1 FUN34 yaaH family protein AW19_3953 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AW19_3954 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AW19_3955 ENOG41063Z6 transcriptional regulator, lysR family AW19_3957 ENOG4105DTN riboflavin biosynthesis protein ribF AW19_3958 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AW19_3959 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AW19_3960 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AW19_3961 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AW19_3962 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AW19_3963 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AW19_3964 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AW19_3965 ENOG4105N14 lysine exporter protein LysE YggA AW19_3966 ENOG4105DWK Membrane AW19_3968 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AW19_397 ENOG4105CHM Aminotransferase AW19_3971 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AW19_3972 ENOG4105NWN ApaG protein AW19_3974 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AW19_3975 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AW19_3976 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AW19_3978 ENOG4105D3G Pseudouridine synthase AW19_3979 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) AW19_398 ENOG4108VKM cytochrome b561 AW19_3980 ENOG4105CQ2 DNA polymerase AW19_3981 ENOG4108KF1 Membrane AW19_3983 ENOG4106SMU thiamine transporter membrane protein AW19_3984 ENOG4105DP9 ABC transporter AW19_3985 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AW19_3986 ENOG4105F1A Pyruvate formate-lyase AW19_3987 ENOG4105C6N Formate acetyltransferase AW19_3988 ENOG4105S8Q sugar efflux transporter AW19_3989 ENOG4105C0F tryptophanase EC 4.1.99.1 AW19_3992 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AW19_3993 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AW19_3994 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AW19_3996 ENOG41064T2 transcriptional regulator, lysR family AW19_3997 ENOG4108IQE Amp-dependent synthetase and ligase AW19_3998 ENOG4105C7K acetolactate synthase AW19_3999 ENOG4108ZP8 Acetolactate synthase small subunit AW19_4 ENOG4105CHR reductase AW19_400 ENOG4106B0W Curli production assembly transport component CsgG AW19_4000 ENOG4107B7Y DNA-binding transcriptional regulator FruR AW19_4002 ENOG4108V6E Cell division protein mraZ AW19_4003 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AW19_4004 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AW19_4005 ENOG4105CJN penicillin-binding protein AW19_4006 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AW19_4007 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AW19_4010 ENOG4105CNI cell division protein FtsW AW19_4011 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AW19_4012 ENOG4105DFU Cell wall formation (By similarity) AW19_4014 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AW19_4015 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AW19_4016 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AW19_4019 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) AW19_402 ENOG4107Y60 (LipO)protein AW19_4020 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AW19_4021 ENOG4105M6F mutator MutT protein AW19_4022 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AW19_4024 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AW19_4025 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AW19_4026 ENOG4105D7Q type ii secretion system AW19_4027 ENOG4107QHF type ii secretion system protein e AW19_4028 ENOG4108ZUW Major pilin subunit AW19_4029 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AW19_4031 ENOG4106A72 regulatory protein AmpE AW19_4032 ENOG4105C85 amino acid AW19_4033 ENOG41073TP transcriptional regulator AW19_4034 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AW19_4035 ENOG4107QSN dihydrolipoamide acetyltransferase AW19_4036 ENOG4107QN2 dihydrolipoyl dehydrogenase AW19_4038 ENOG4105ECQ AraC Family Transcriptional Regulator AW19_4039 ENOG4107RNH Outer membrane receptor FepA AW19_404 ENOG4108NEM leader-binding protein dmsD AW19_4040 ENOG4107QIJ Aconitate hydratase 2 AW19_4042 ENOG4105RPH Inner membrane protein YddG AW19_4043 ENOG4108ZIG UPF0231 protein AW19_4044 ENOG4105CKT filamentous hemagglutinin AW19_4046 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AW19_4047 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AW19_4048 ENOG4108ZRK uncharacterized protein yacC AW19_4049 ENOG4105E3B Multicopper oxidase AW19_405 ENOG4107KGK dmso reductase anchor subunit AW19_4051 ENOG4108UGV hypoxanthine phosphoribosyltransferase AW19_4052 ENOG41077A9 carbonic anhydrase AW19_4053 ENOG4105DA5 (ABC) transporter AW19_4054 ENOG4105E3A (ABC) transporter AW19_4055 ENOG4107BJW polysaccharide deacetylase AW19_4056 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AW19_4057 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AW19_4058 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AW19_4059 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AW19_406 ENOG4105QAX Iron-sulfur AW19_4060 ENOG4105DJ0 Poly(A) Polymerase AW19_4062 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AW19_4063 ENOG4105PW4 Sugar fermentation stimulation protein homolog AW19_4064 ENOG4107XID 2'-5' rna ligase AW19_4065 ENOG4105CQ7 ATP-dependent helicase AW19_4066 ENOG4105BZ4 penicillin-binding protein AW19_4067 ENOG4105E0A ABC, transporter AW19_4068 ENOG4105J76 Periplasmic binding protein AW19_4069 ENOG4105S6R Iron-hydroxamate transporter permease subunit AW19_407 ENOG4107QY8 reductase AW19_4070 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AW19_4072 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AW19_4074 ENOG4105EN6 Membrane AW19_4076 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AW19_4077 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AW19_4078 ENOG4105C0H protease AW19_4079 ENOG4105BZU Histidine kinase AW19_4080 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AW19_4081 ENOG4105DXN mazG family AW19_4082 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AW19_4083 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AW19_4089 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AW19_409 ENOG4105E82 cytochrome subunit of dehydrogenase AW19_4090 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AW19_4091 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AW19_4092 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AW19_4093 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AW19_4094 ENOG4108MXK alkaline phosphatase isozyme conversion AW19_4095 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW19_4096 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AW19_4097 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AW19_4098 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AW19_4099 ENOG4105N0Z inner membrane protein ygbE AW19_41 ENOG4107VXZ Hydrolase AW19_410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW19_4101 ENOG4105DRP amino acid AbC transporter AW19_4102 ENOG4106PMH Extracellular solute-binding protein family 3 AW19_4103 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AW19_4105 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AW19_4106 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AW19_4107 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AW19_4108 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AW19_4109 ENOG4108K5P (LipO)protein AW19_4110 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW19_4111 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AW19_4116 ENOG4106PG1 outer membrane usher protein AW19_4117 ENOG4108FZ9 Chaperone AW19_4119 ENOG4105NEV Fimbrial AW19_4120 ENOG4105H8W Fimbrial protein AW19_4125 ENOG4108JJA ABC, transporter AW19_4126 ENOG4105DJY efflux transporter, rnd family, mfp subunit AW19_4127 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW19_4128 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AW19_4129 ENOG4105EJX conjugal transfer ATPase AW19_413 ENOG4105CVE Lytic murein transglycosylase AW19_414 ENOG4105CUB amino acid AW19_4141 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AW19_4145 ENOG4105YES addiction module antidote protein AW19_4146 ENOG4105VUH addiction module killer protein AW19_4156 ENOG4107SKI cobyrinic Acid a,c-diamide synthase AW19_4173 ENOG4105KF5 hemolysin expression-modulating protein AW19_4176 ENOG4108X73 DNA- binding protein AW19_4177 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AW19_4182 ENOG4105K5T PilT protein AW19_4185 ENOG4107QHF type ii secretion system protein e AW19_419 ENOG4105DHJ ABC, transporter AW19_4194 ENOG4108EHY type IV secretion system AW19_4197 ENOG4108V42 Type IV secretion system protein VirB8 AW19_42 ENOG4105W39 Membrane AW19_422 ENOG4105DS1 cytochrome b561 AW19_423 ENOG4108YYC ycei family AW19_424 ENOG4105DDV Transcriptional regulator (LacI family AW19_425 ENOG4105C5Y PTS System AW19_426 ENOG4105CS2 ec 3.2.1.21 AW19_43 ENOG4105D9M gamma-glutamylcysteine synthetase AW19_430 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AW19_431 ENOG4105EZE Cupin 4 family protein AW19_432 ENOG4108JJ7 ABC transporter AW19_437 ENOG4108N8T regulatoR AW19_439 ENOG4105VEQ Cold shock protein AW19_44 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) AW19_440 ENOG4107Z6W Protein CrcB homolog AW19_441 ENOG4105BZU Histidine kinase AW19_442 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) AW19_443 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AW19_444 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AW19_445 ENOG4108Z43 UPF0250 protein AW19_446 ENOG4105DZ1 carboxypeptidase AW19_447 ENOG4105K6T rare lipoprotein A AW19_448 ENOG4105CNI cell division protein FtsW AW19_449 ENOG4105CJN penicillin-binding protein AW19_45 ENOG4108JU6 CBS domain protein AW19_451 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AW19_452 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AW19_453 ENOG4105DJF DNA polymerase III, delta' subunit AW19_454 ENOG4108U2H Rare lipoprotein B AW19_456 ENOG4107PAI alpha helical protein AW19_458 ENOG4105CDA abc transporter atp-binding protein AW19_459 ENOG4105DRP amino acid AbC transporter AW19_46 ENOG4106KVJ cytochrome C assembly protein AW19_460 ENOG4105EAD ABC transporter AW19_461 ENOG4107RP9 extracellular solute-binding protein, family 3 AW19_463 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AW19_464 ENOG4108JU5 Magnesium and cobalt efflux protein AW19_465 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AW19_466 ENOG4105C9A Phoh family AW19_467 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AW19_468 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AW19_47 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AW19_474 ENOG4105CAQ asparagine synthetase AW19_475 ENOG4105D4U had-superfamily hydrolase, subfamily iia AW19_476 ENOG4105E2R ROK family AW19_477 ENOG4105CE4 GlcNAc 6-P deacetylase AW19_478 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AW19_479 ENOG4105CI1 PTS System AW19_480 ENOG4105CX6 glutaminyL-tRNA synthetase AW19_482 ENOG4105GX6 (LipO)protein AW19_484 ENOG41090R7 Ferric uptake AW19_485 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AW19_486 ENOG4105C8Q Methyl-accepting chemotaxis AW19_487 ENOG4105NNH LexA regulated protein AW19_489 ENOG4105EV9 Alpha Beta Hydrolase AW19_49 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AW19_491 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AW19_494 ENOG4105EEX Two component transcriptional regulator (Winged helix family AW19_495 ENOG4105C08 Histidine kinase AW19_496 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) AW19_497 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AW19_498 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AW19_499 ENOG4105XIQ Protein of unknown function (DUF2517) AW19_5 ENOG4105E89 ABC transporter AW19_50 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AW19_500 ENOG4107SEY Conserved Protein AW19_501 ENOG4105CVP deoxyribo-dipyrimidine photolyase AW19_502 ENOG4107RF4 Phosphodiesterase AW19_503 ENOG4107QNR UPF0135 protein AW19_504 ENOG4105P4J Allophanate hydrolase, subunit 1 AW19_505 ENOG4107R7A Allophanate hydrolase subunit 2 AW19_506 ENOG4105E7W lamb ycsf family protein AW19_509 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) AW19_51 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AW19_510 ENOG4105BZN citrate synthase AW19_511 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AW19_512 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AW19_514 ENOG4105E33 succinate dehydrogenase AW19_515 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AW19_516 ENOG4105C7S Dehydrogenase AW19_518 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AW19_519 ENOG4105CGH 5'-nucleotidase AW19_52 ENOG4108NE3 Salt-induced outer membrane protein AW19_520 ENOG4105C4M (Ubiquinol oxidase) subunit I AW19_521 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AW19_523 ENOG4105KJB cyd operon protein YbgE AW19_524 ENOG4107YD3 Thioesterase AW19_525 ENOG4105E02 MotA TolQ exbB proton channel AW19_526 ENOG4105M8F Biopolymer transport protein exbD tolR AW19_527 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA AW19_527 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA AW19_528 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AW19_529 ENOG4105KCK Peptidoglycan-associated lipoprotein AW19_53 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AW19_530 ENOG4105UFD tol-pal system protein YbgF AW19_535 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AW19_536 ENOG4106Z1T Nicotinamide Mononucleotide Transporter AW19_537 ENOG4105PGM cation diffusion facilitator family transporter AW19_538 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AW19_539 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AW19_54 ENOG4108NEV two component transcriptional regulator, LytTR family AW19_541 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) AW19_542 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AW19_543 ENOG4105F0Z galactose-1-phosphate uridylyltransferase AW19_544 ENOG4105CMR udp-glucose 4-epimerase AW19_546 ENOG4105DKW ABC transporter AW19_547 ENOG4105F4R Transcriptional regulator mode AW19_548 ENOG410680R Protein of unknown function (DUF2592) AW19_549 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AW19_55 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AW19_550 ENOG4105E0C molybdate abc transporter AW19_552 ENOG4108K4B hydrolase AW19_553 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AW19_555 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AW19_556 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AW19_557 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW19_558 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AW19_559 ENOG4108IV0 ABC, transporter AW19_560 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AW19_561 ENOG4105CHW UPF0052 protein AW19_562 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AW19_563 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AW19_564 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AW19_565 ENOG4105M00 molybdopterin converting factor, subunit 1 AW19_566 ENOG4108ZAF Molybdopterin AW19_567 ENOG4105HFZ Membrane AW19_568 ENOG4107QWP ABC-2 type transporter AW19_569 ENOG4107QWP ABC-2 type transporter AW19_57 ENOG4105CQC Prephenate dehydratase AW19_570 ENOG4105CJ1 ABC, transporter AW19_571 ENOG4105D0S secretion protein (HlyD AW19_572 ENOG4107MVR Transcriptional regulator AW19_573 ENOG4105C1J atp-dependent rna helicase AW19_574 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AW19_576 ENOG4105CJW magnesium transporter AW19_578 ENOG41061WM D-Alanyl-D-Alanine AW19_579 ENOG4105CXG d-lactate dehydrogenase AW19_58 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA AW19_581 ENOG4105N1F Hnh endonuclease AW19_583 ENOG4105Y3U Transglycosylase-associated protein AW19_585 ENOG4105EHI Phosphonate ABC transporter, periplasmic AW19_588 ENOG4108W15 Protein of unknown function (DUF1456) AW19_589 ENOG4105KHC sulfurtransferase AW19_59 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AW19_592 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system AW19_593 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component AW19_594 ENOG4108IJ8 ABC transporter AW19_595 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component AW19_598 ENOG4105FDR Membrane AW19_6 ENOG4105CA0 peroxidase AW19_60 ENOG4105C34 Pseudouridine synthase AW19_601 ENOG4105DVT helicase AW19_602 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AW19_603 ENOG4108MTB glycosyl transferase family AW19_606 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) AW19_607 ENOG4107SDU Methyl-accepting chemotaxis AW19_608 ENOG4105CDA abc transporter atp-binding protein AW19_609 ENOG4105E5Q amino acid AbC transporter AW19_61 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AW19_610 ENOG4107R0W ABC transporter AW19_611 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction AW19_612 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AW19_618 ENOG4108T1M outer membrane protein x AW19_62 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AW19_620 ENOG4105C5H ABC transporter AW19_621 ENOG4105D06 uba thif-type nad fad binding protein AW19_622 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW19_624 ENOG4105CSH Transporter AW19_626 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW19_632 ENOG4105EGI Transcriptional regulator AW19_633 ENOG4105CBP Major Facilitator AW19_634 ENOG4105EUJ GTP cyclohydrolase i AW19_635 ENOG4105DHF Membrane AW19_636 ENOG41060NJ transcriptional regulator AW19_639 ENOG4107SDZ Galactoside transport system permease protein mglC AW19_640 ENOG4105TMB Formate nitrite transporter AW19_641 ENOG4108JUA Transcriptional regulator AW19_642 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AW19_643 ENOG4108RC0 Electron transport protein AW19_644 ENOG4108MG9 hydrogenase 3 maturation protease AW19_645 ENOG4105I6X formate hydrogenlyase maturation AW19_646 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit AW19_648 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW19_649 ENOG4108JPZ Monovalent cation H antiporter subunit D AW19_650 ENOG4107WQX hydrogenase 4 membrane subunit AW19_651 ENOG4105D65 subunit l AW19_652 ENOG4107TDF Formate hydrogenlyase subunit 4 AW19_653 ENOG4108JPZ Monovalent cation H antiporter subunit D AW19_654 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) AW19_655 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) AW19_657 ENOG4107GZ4 SanA protein AW19_658 ENOG4107R1I NAD-dependent malic enzyme AW19_661 ENOG41067MG lrgb family AW19_662 ENOG4105VAW lrga family AW19_663 ENOG4105E5W Transporter AW19_667 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AW19_668 ENOG4105D1F ATP-binding protein AW19_669 ENOG4105DBI uridine monophosphokinase AW19_670 ENOG4105DHP deoxycytidine triphosphate deaminase AW19_671 ENOG4108GAE asmA family AW19_672 ENOG4105CEE C4-dicarboxylate transporter AW19_673 ENOG4105EE5 Membrane protein terC AW19_674 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AW19_675 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AW19_676 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AW19_677 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AW19_678 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AW19_679 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AW19_680 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AW19_681 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AW19_682 ENOG4105CIH Imidazole acetol-phosphate transaminase AW19_684 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AW19_685 ENOG4108535 NAD dependent epimerase/dehydratase family AW19_686 ENOG4105CNN ABC, transporter AW19_687 ENOG4105C2J ABC transporter AW19_688 ENOG4107SCQ Iron-containing alcohol dehydrogenase AW19_69 ENOG4105CV8 reductase AW19_690 ENOG4105CUB amino acid AW19_691 ENOG4105CJB Exodeoxyribonuclease I AW19_692 ENOG4105E4E Thioester reductase domain-containing protein AW19_693 ENOG4105DR8 Membrane AW19_695 ENOG4107SDZ Galactoside transport system permease protein mglC AW19_696 ENOG4105CNN ABC, transporter AW19_697 ENOG4105C2J ABC transporter AW19_698 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AW19_699 ENOG4105JZC GHMP kinase AW19_70 ENOG4105HEI LysR family (Transcriptional regulator AW19_700 ENOG4107QZB decarboxylase AW19_701 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW19_702 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AW19_703 ENOG4105KTW ethanolamine utilization protein AW19_704 ENOG4105M3W utilization protein AW19_706 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) AW19_708 ENOG4108EKI Dehydrogenase AW19_71 ENOG4105F27 Major Facilitator AW19_710 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml AW19_712 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) AW19_714 ENOG4105KNY Microcompartments protein AW19_716 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit AW19_717 ENOG4108ZFT Dehydratase small subunit AW19_718 ENOG4105YCI dehydratase medium subunit AW19_719 ENOG4105DMB glycerol dehydratase AW19_720 ENOG4105EHR propanediol utilization protein pduB AW19_721 ENOG4105KNY Microcompartments protein AW19_723 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AW19_724 ENOG4107XVH Transcriptional regulator AW19_725 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AW19_726 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AW19_727 ENOG41081F0 Precorrin-8x methylmutase AW19_728 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) AW19_729 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase AW19_73 ENOG4107NA1 Endonuclease Exonuclease phosphatase AW19_730 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase AW19_731 ENOG4105CIA precorrin-4 C(11)-methyltransferase AW19_732 ENOG4108P62 biosynthesis protein (CbiG) AW19_733 ENOG4105E4R Precorrin-3B C17-methyltransferase AW19_734 ENOG4105QUC reductase AW19_735 ENOG4107PPM cobalt chelatase AW19_736 ENOG4105DVK Precorrin-2 c20-methyltransferase AW19_737 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) AW19_739 ENOG4108V4M Cobalt abc transporter AW19_74 ENOG4105E9H Lytic Murein transglycosylase AW19_741 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AW19_742 ENOG4108YZT Adenosylcobinamide kinase AW19_743 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AW19_744 ENOG4108TGR phosphatase AW19_745 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AW19_746 ENOG4105CN8 Transcriptional regulator AW19_748 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AW19_749 ENOG4105EAA nucleoside AW19_75 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AW19_750 ENOG4105CDH Citrulline--aspartate ligase AW19_751 ENOG4105UQX Mate efflux family protein AW19_753 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AW19_754 ENOG410667J hydrolase AW19_755 ENOG4105E98 transcriptional regulator DeoR family AW19_756 ENOG4107RTG Major Facilitator superfamily AW19_757 ENOG4107S1E Beta-lactamase AW19_758 ENOG4105HEI LysR family (Transcriptional regulator AW19_759 ENOG4107R88 Chemotaxis protein (CheV) AW19_76 ENOG4105D1A Methyltransferase AW19_761 ENOG4108MQF Chaperone AW19_764 ENOG4108MQF Chaperone AW19_766 ENOG4105BZU Histidine kinase AW19_767 ENOG4108Q9V regulatoR AW19_769 ENOG4108UQ8 endoribonuclease L-psp AW19_77 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AW19_771 ENOG4108TSE Transferase AW19_774 ENOG4105C0W non-ribosomal peptide synthetase AW19_779 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AW19_78 ENOG4107RZZ dna polymerase iii epsilon subunit AW19_782 ENOG4107ZSV Receptor AW19_784 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW19_785 ENOG4108EU3 peptide transport system, permease AW19_791 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW19_792 ENOG4107RCV ABC transporter, permease AW19_793 ENOG4105C4Y ABC transporter AW19_794 ENOG4105CXY transporter AW19_795 ENOG4105BZU Histidine kinase AW19_796 ENOG4108KX4 response regulator AW19_797 ENOG4106YYS transcriptional regulatory protein AW19_798 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AW19_799 ENOG4105DUA (citrate (pro-3S)-lyase ligase AW19_8 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AW19_80 ENOG4105GIJ Glycine betaine AW19_800 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) AW19_801 ENOG4105CI0 Citrate lyase AW19_802 ENOG4105CHY citrate lyase, alpha AW19_803 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase AW19_804 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase AW19_805 ENOG4107QPK )-transporter AW19_806 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AW19_808 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AW19_809 ENOG4108TSE Transferase AW19_81 ENOG4108HQS Glycine betaine AW19_812 ENOG4105D3G Pseudouridine synthase AW19_816 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) AW19_818 ENOG4105EQR Transposase IS116 IS110 IS902 AW19_82 ENOG4108IJ7 Glycine betaine AW19_821 ENOG4108D1K outer membrane usher protein AW19_822 ENOG4108S1B Periplasmic chaperone protein AW19_823 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase AW19_824 ENOG4108HPI phosphatidate Cytidylyltransferase AW19_826 ENOG4105E8V Alpha Beta Hydrolase Fold protein AW19_827 ENOG41077RS Phosphatase AW19_83 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW19_830 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AW19_831 ENOG4105D6F Phosphatase AW19_832 ENOG41061EV selenium-binding protein YdfZ AW19_835 ENOG4105GSJ Inner membrane protein ylaC AW19_837 ENOG4105CNT hydrolase family 2 AW19_838 ENOG4105ETE Transcriptional regulator (LacI family AW19_839 ENOG4105VEQ Cold shock protein AW19_840 ENOG4105VZF DsrB protein AW19_841 ENOG4105C8Q Methyl-accepting chemotaxis AW19_842 ENOG4105KT7 mgtC SapB transporter AW19_843 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AW19_844 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AW19_845 ENOG4108VA4 Universal stress protein AW19_846 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) AW19_847 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region AW19_848 ENOG4107RD7 Flagellar Motor Protein, MotA AW19_849 ENOG4105ER2 Ompa motb domain protein AW19_85 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AW19_850 ENOG4105CBS Chea signal transduction histidine kinase AW19_851 ENOG4108V3W Chemotaxis protein, CheW AW19_852 ENOG4105C8Q Methyl-accepting chemotaxis AW19_853 ENOG4105C8Q Methyl-accepting chemotaxis AW19_854 ENOG4105BZU Histidine kinase AW19_856 ENOG4108VYJ response regulator receiver protein AW19_857 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) AW19_858 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin AW19_859 ENOG4105D00 flagellar biosynthetic protein flhB AW19_86 ENOG4105WAZ (Glutaredoxin-like protein) NrdH AW19_860 ENOG4105D7B Flagellar biosynthesis protein flha AW19_862 ENOG4105W13 flagellar protein AW19_863 ENOG4105QVD Flagella synthesis protein FlgN AW19_864 ENOG4105M9M anti-sigma28 factor FlgM AW19_865 ENOG4105CKS Flagella basal body P-ring formation protein flgA AW19_866 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AW19_867 ENOG4108ZC9 flagellar basal-body rod protein flgc AW19_868 ENOG4105W00 Flagellar hook capping protein AW19_869 ENOG4105BZE flagellar hook protein, FlgE AW19_87 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AW19_870 ENOG4108KPB Flagellar basal-body rod protein FlgF AW19_871 ENOG4105CGA flagellar basal-body rod protein FlgG AW19_874 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AW19_875 ENOG4105E1Q flagellar hook-associated protein AW19_876 ENOG4105DTJ flagellar hook-associated protein AW19_877 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AW19_878 ENOG4105VS8 Flagellar biosynthetic protein fliq AW19_879 ENOG4105CN7 Flagellar biosynthetic protein FliP AW19_881 ENOG4105DD5 Flagellar motor switch protein AW19_882 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AW19_883 ENOG4107ZI8 flagellar basal body-associated protein flil AW19_884 ENOG4105WF4 Flagellar hook-length control protein AW19_885 ENOG4105GSA Flagellar export protein flij AW19_886 ENOG4108JIR Flagellum-specific ATP synthase AW19_887 ENOG41090PJ Flagellar assembly protein AW19_888 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AW19_889 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AW19_89 ENOG4105TNS Conserved Protein AW19_890 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AW19_893 ENOG4105DHT Metal Dependent Phosphohydrolase AW19_895 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) AW19_896 ENOG4105MQ3 flagellar protein FliS AW19_897 ENOG4105DTS flagellar hook-associated AW19_899 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW19_9 ENOG4105YVS arsR family transcriptional regulator AW19_900 ENOG4108M9K flagella biosynthesis protein FliZ AW19_901 ENOG4105K6H D-cysteine desulfhydrase AW19_902 ENOG4105EAB amino acid AbC transporter AW19_903 ENOG4105E5Q amino acid AbC transporter AW19_904 ENOG4105CDA abc transporter atp-binding protein AW19_908 ENOG4105C26 Dehydrogenase AW19_909 ENOG4105CK7 Sodium proline symporter AW19_913 ENOG4105CS1 NAD(P)H quinone oxidoreductase AW19_914 ENOG4105CSH Transporter AW19_916 ENOG4105HVQ Regulatory factor of maltose metabolism AW19_918 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) AW19_921 ENOG4108KU3 Integrase AW19_923 ENOG4108KU3 Integrase AW19_926 ENOG4105CKK Glycosyl transferase, family 2 AW19_93 ENOG4108WMJ Protein of unknown function (DUF2002) AW19_930 ENOG4105E5K Alpha-amylase AW19_932 ENOG4105XVG cytoplasmic protein AW19_933 ENOG4105WH1 Two component transcriptional regulator luxr family AW19_934 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AW19_935 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AW19_94 ENOG4108SAJ Protein of unknown function (DUF1198) AW19_942 ENOG4105C85 amino acid AW19_944 ENOG4108MRH transcriptional regulatory protein AW19_945 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AW19_946 ENOG4105MVE transcriptional regulator AW19_947 ENOG4105G63 Type III effector Hrp-dependent AW19_948 ENOG4105FB2 class II Aldolase AW19_949 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AW19_950 ENOG4105CSV Glutaminase AW19_954 ENOG4107SJW iron permease, FTR1 AW19_957 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW19_959 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW19_96 ENOG4105VEQ Cold shock protein AW19_963 ENOG4105EXG Transcriptional regulator AW19_964 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW19_965 ENOG4108819 ferric iron reductase AW19_966 ENOG4107RAQ aminopeptidase AW19_967 ENOG4108TUY outer membrane protein PgaA AW19_968 ENOG4107BJW polysaccharide deacetylase AW19_969 ENOG4105CND Glycosyl transferase, family 2 AW19_970 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD AW19_973 ENOG4105D5M phosphate starvation-inducible protein AW19_974 ENOG4105EWV Sodium calcium exchanger membrane region AW19_976 ENOG4107R11 Transcriptional regulator AW19_977 ENOG4105BZU Histidine kinase AW19_978 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AW19_979 ENOG4105C4M (Ubiquinol oxidase) subunit I AW19_981 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW19_982 ENOG4105C8Y Acetylornithine aminotransferase AW19_983 ENOG4105F4X arginine AW19_985 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) AW19_986 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) AW19_989 ENOG4105CI2 imidazolone-5-propionate hydrolase AW19_990 ENOG4105CZE histidine utilization repressor AW19_991 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AW19_992 ENOG41090B9 response to stress AW19_994 ENOG4105C2J ABC transporter AW19_995 ENOG4108HWV )-transporter AW19_996 ENOG4108MEK Metal-binding protein YodA AW19_998 ENOG4108K5P (LipO)protein