locus-tag	class	description
AW19_100	COG0747	negative chemotaxis
AW19_1000	COG0012	GTP binding
AW19_1002	COG0193	aminoacyl-tRNA hydrolase activity
AW19_1004	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AW19_1006	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AW19_1007	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AW19_1008	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AW19_1009	COG2890	protein-(glutamine-N5) methyltransferase activity
AW19_1010	COG3094	Invasion gene expression up-regulator, SirB
AW19_1011	COG2912	Transglutaminase-like superfamily
AW19_1012	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AW19_1013	COG0659	secondary active sulfate transmembrane transporter activity
AW19_1019	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AW19_102	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AW19_1020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AW19_1021	COG3381	protein complex oligomerization
AW19_1023	COG0477	Major facilitator Superfamily
AW19_1024	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW19_1026	COG0673	inositol 2-dehydrogenase activity
AW19_1027	COG0728	peptidoglycan biosynthetic process
AW19_1028	COG0018	arginyl-trna synthetase
AW19_1029	COG3102	Protein conserved in bacteria
AW19_1030	COG3142	Participates in the control of copper homeostasis
AW19_1031	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AW19_1032	COG2226	methyltransferase
AW19_1033	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AW19_1034	COG1801	Protein of unknown function DUF72
AW19_1035	COG1335	isochorismatase
AW19_1036	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AW19_1037	COG0494	nUDIX hydrolase
AW19_1038	COG0217	transcriptional regulatory protein
AW19_1039	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AW19_104	COG1124	(ABC) transporter
AW19_1040	COG0632	four-way junction helicase activity
AW19_1041	COG2255	four-way junction helicase activity
AW19_1042	COG3104	oligopeptide transport
AW19_1043	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AW19_1044	COG1121	(ABC) transporter
AW19_1045	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AW19_1046	COG0739	heme binding
AW19_1047	COG1560	Kdo2-lipid A biosynthetic process
AW19_1048	COG0469	pyruvate kinase activity
AW19_1049	COG1737	Transcriptional regulator
AW19_1050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AW19_1051	COG0800	Aldolase
AW19_1052	COG2076	Multidrug Resistance protein
AW19_1053	COG2076	Multidrug Resistance protein
AW19_1054	COG0251	oxidation-reduction process
AW19_1055	COG1199	ATP-dependent helicase activity
AW19_1057	COG3065	identical protein binding
AW19_1058	COG0318	PFAM AMP-dependent synthetase and ligase
AW19_1059	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AW19_1060	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AW19_1061	COG2894	cell division
AW19_1062	COG0850	regulation of cytokinetic process
AW19_1064	COG3100	YcgL domain-containing protein
AW19_1065	COG2951	lytic endotransglycosylase activity
AW19_1066	COG0179	Fumarylacetoacetate (FAA) hydrolase
AW19_1067	COG2983	Belongs to the UPF0260 family
AW19_107	COG0832	Belongs to the urease beta subunit family
AW19_1070	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AW19_1071	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AW19_1072	COG2186	Transcriptional regulator
AW19_1073	COG2719	SpoVR family
AW19_1074	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AW19_1075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AW19_1076	COG2814	Major facilitator Superfamily
AW19_1077	COG2202	Pas domain
AW19_1077	COG2200	EAL domain
AW19_1077	COG2199	diguanylate cyclase activity
AW19_1079	COG0583	DNA-binding transcription factor activity
AW19_108	COG0804	urea catabolic process
AW19_1081	COG2718	Belongs to the UPF0229 family
AW19_1082	COG2766	serine protein kinase
AW19_1083	COG3713	MltA-interacting MipA family protein
AW19_1086	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AW19_1087	COG3139	Protein of unknown function (DUF1315)
AW19_1088	COG1335	isochorismatase
AW19_1089	COG0252	asparaginase activity
AW19_109	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AW19_1090	COG0616	signal peptide processing
AW19_1091	COG0778	Nitroreductase
AW19_1093	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AW19_1095	COG0494	nUDIX hydrolase
AW19_1096	COG0708	Exodeoxyribonuclease III
AW19_1097	COG0583	DNA-binding transcription factor activity
AW19_1101	COG0788	formyltetrahydrofolate deformylase activity
AW19_1102	COG3012	SEC-C Motif Domain Protein
AW19_1104	COG1752	Esterase of the alpha-beta hydrolase superfamily
AW19_1105	COG0745	RESPONSE REGULATOR receiver
AW19_1107	COG2916	Histone family protein nucleoid-structuring protein H-NS
AW19_1108	COG1435	thymidine kinase activity
AW19_111	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AW19_1111	COG1012	belongs to the aldehyde dehydrogenase family
AW19_1111	COG1454	alcohol dehydrogenase
AW19_1112	COG2095	MarC family integral membrane protein
AW19_1116	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AW19_1117	COG0444	Belongs to the ABC transporter superfamily
AW19_1118	COG4608	Belongs to the ABC transporter superfamily
AW19_112	COG0829	nickel cation binding
AW19_1120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AW19_1121	COG2200	EAL domain
AW19_1124	COG2350	Protein conserved in bacteria
AW19_1125	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AW19_1126	COG1607	acyl-coa hydrolase
AW19_1127	COG2917	probably involved in intracellular septation
AW19_113	COG4413	Urea transporter
AW19_1130	COG3047	cAMP biosynthetic process
AW19_1132	COG0159	tryptophan synthase activity
AW19_1133	COG0133	tryptophan synthase activity
AW19_1134	COG0134	indole-3-glycerol-phosphate synthase activity
AW19_1134	COG0135	phosphoribosylanthranilate isomerase activity
AW19_1136	COG0512	Glutamine amidotransferase of anthranilate synthase
AW19_1137	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AW19_1138	COG0613	PHP domain protein
AW19_1139	COG0009	L-threonylcarbamoyladenylate synthase
AW19_114	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AW19_1159	COG1187	pseudouridine synthase activity
AW19_116	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AW19_1161	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AW19_1162	COG1028	Short-chain dehydrogenase reductase Sdr
AW19_1163	COG0616	signal peptide processing
AW19_1165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AW19_1166	COG0583	DNA-binding transcription factor activity
AW19_117	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AW19_1170	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AW19_1171	COG0671	phosphoesterase, PA-phosphatase related
AW19_1172	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AW19_1173	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AW19_1176	COG0284	orotidine-5'-phosphate decarboxylase activity
AW19_1177	COG0023	Translation Initiation Factor
AW19_1179	COG0235	Class ii aldolase
AW19_1181	COG1349	DNA-binding transcription factor activity
AW19_1182	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AW19_1183	COG2879	small protein
AW19_1184	COG1966	Carbon starvation protein
AW19_1185	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AW19_1187	COG0243	molybdopterin cofactor binding
AW19_119	COG0667	Aldo Keto reductase
AW19_1191	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AW19_1193	COG4659	FMN binding
AW19_1194	COG4658	electron transport chain
AW19_1195	COG2207	Transcriptional regulator
AW19_1195	COG3708	Transcriptional regulator
AW19_1196	COG4656	Part of a membrane complex involved in electron transport
AW19_120	COG2133	pyrroloquinoline quinone binding
AW19_1200	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AW19_1204	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AW19_1205	COG2160	L-arabinose isomerase activity
AW19_121	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AW19_1211	COG0673	inositol 2-dehydrogenase activity
AW19_1212	COG0385	Bile acid
AW19_1213	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AW19_1214	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AW19_1215	COG1263	PTS System
AW19_1215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW19_1217	COG1609	Transcriptional regulator
AW19_122	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AW19_1220	COG5339	Protein conserved in bacteria
AW19_1222	COG0114	fumarate hydratase activity
AW19_1226	COG2814	Major facilitator Superfamily
AW19_1227	COG0583	DNA-binding transcription factor activity
AW19_1228	COG1940	carbohydrate kinase activity
AW19_1229	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AW19_123	COG2723	6-phospho-beta-galactosidase activity
AW19_1233	COG1742	UPF0060 membrane protein
AW19_1234	COG4221	oxidoreductase activity
AW19_1236	COG3316	Transposase and inactivated derivatives
AW19_1237	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AW19_1238	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AW19_1239	COG3316	Transposase and inactivated derivatives
AW19_124	COG1447	Phosphotransferase system cellobiose-specific component IIA
AW19_1240	COG1393	Belongs to the ArsC family
AW19_1241	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AW19_1242	COG0640	Transcriptional regulator
AW19_1249	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AW19_125	COG2169	Transcriptional regulator
AW19_125	COG1917	Cupin 2, conserved barrel domain protein
AW19_1253	COG0625	glutathione transferase activity
AW19_1254	COG3604	Transcriptional regulator
AW19_1255	COG0426	domain, Protein
AW19_1255	COG1773	rubredoxin
AW19_1256	COG0446	pyridine nucleotide-disulphide oxidoreductase
AW19_1258	COG1522	sequence-specific DNA binding
AW19_126	COG3394	polysaccharide catabolic process
AW19_1260	COG4215	(ABC) transporter
AW19_1264	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AW19_1268	COG3023	N-Acetylmuramoyl-L-alanine amidase
AW19_1270	COG0028	Belongs to the TPP enzyme family
AW19_1271	COG0440	acetolactate synthase activity
AW19_1272	COG1011	Hydrolase
AW19_1275	COG1028	Short-chain dehydrogenase reductase Sdr
AW19_1278	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AW19_128	COG2003	Belongs to the UPF0758 family
AW19_1281	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AW19_1282	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AW19_1283	COG0589	response to stress
AW19_1284	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AW19_1285	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AW19_1287	COG0531	amino acid
AW19_1289	COG0745	RESPONSE REGULATOR receiver
AW19_1290	COG2205	protein histidine kinase activity
AW19_1291	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AW19_1294	COG3591	Belongs to the peptidase S1B family
AW19_1297	COG1643	Atp-dependent helicase
AW19_1298	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AW19_1299	COG3784	Protein of unknown function (DUF1318)
AW19_1301	COG2911	Protein conserved in bacteria
AW19_1302	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AW19_1303	COG3042	response to heat
AW19_1304	COG1285	pathogenesis
AW19_1306	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AW19_1306	COG0674	pyruvate-flavodoxin oxidoreductase activity
AW19_1306	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AW19_1306	COG1013	pyruvate-flavodoxin oxidoreductase activity
AW19_1308	COG0037	tRNA processing
AW19_1309	COG0598	Magnesium transport protein CorA
AW19_1311	COG4166	transmembrane transport
AW19_1312	COG4948	Mandelate Racemase Muconate Lactonizing
AW19_1313	COG2866	Carboxypeptidase
AW19_1314	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AW19_1318	COG3768	UPF0283 membrane protein
AW19_1319	COG3106	COG3106 Predicted ATPase
AW19_1321	COG1983	PspC domain protein
AW19_1323	COG1842	Phage shock protein A
AW19_1324	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AW19_1327	COG4166	transmembrane transport
AW19_1328	COG4168	peptide transport system, permease
AW19_1329	COG4171	peptide transport system, permease
AW19_1331	COG4172	Belongs to the ABC transporter superfamily
AW19_1332	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AW19_1332	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AW19_1334	COG3104	oligopeptide transport
AW19_1338	COG0625	glutathione transferase activity
AW19_1340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AW19_1342	COG3895	Periplasmic Protein
AW19_1343	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AW19_1344	COG3133	Outer membrane lipoprotein
AW19_1345	COG1846	Transcriptional regulator
AW19_1347	COG1566	PFAM secretion protein HlyD family protein
AW19_1348	COG1289	transmembrane transporter activity
AW19_1349	COG4989	oxidoreductase activity
AW19_1351	COG3313	Fe-S protein
AW19_1353	COG2194	sulfuric ester hydrolase activity
AW19_1354	COG1309	transcriptional regulator
AW19_1355	COG1902	pentaerythritol trinitrate reductase activity
AW19_1356	COG0346	lactoylglutathione lyase activity
AW19_1357	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AW19_1358	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AW19_1359	COG0791	NLP P60 protein
AW19_136	COG3311	Transcriptional regulator
AW19_1360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AW19_1362	COG1609	Transcriptional regulator
AW19_1363	COG0583	DNA-binding transcription factor activity
AW19_1364	COG2814	Major facilitator Superfamily
AW19_1365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AW19_1366	COG0307	riboflavin synthase, alpha
AW19_1367	COG0534	Mate efflux family protein
AW19_1372	COG4238	major outer membrane lipoprotein
AW19_1373	COG1388	LysM domain
AW19_1373	COG1376	ErfK ybiS ycfS ynhG family protein
AW19_1374	COG2166	iron-sulfur cluster assembly
AW19_1376	COG0719	Fe-S assembly protein
AW19_1377	COG0396	ATPase activity
AW19_1378	COG0719	Fe-S assembly protein
AW19_1379	COG0316	Belongs to the HesB IscA family
AW19_1380	COG2050	protein possibly involved in aromatic compounds catabolism
AW19_1381	COG0247	lactate metabolic process
AW19_1381	COG0277	FAD linked oxidase domain protein
AW19_1382	COG0628	permease
AW19_1383	COG0574	Belongs to the PEP-utilizing enzyme family
AW19_1383	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AW19_1384	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AW19_1387	COG3720	iron ion transport
AW19_1388	COG4558	Periplasmic binding protein
AW19_1390	COG0095	Lipoate-protein ligase
AW19_1391	COG0791	NLP P60 protein
AW19_1392	COG2076	Multidrug Resistance protein
AW19_1393	COG2076	Multidrug Resistance protein
AW19_1394	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AW19_1395	COG0726	polysaccharide deacetylase
AW19_1396	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW19_1396	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AW19_1397	COG0463	Glycosyl transferase, family 2
AW19_1398	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AW19_1399	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AW19_1400	COG0386	Belongs to the glutathione peroxidase family
AW19_1401	COG4139	cobalamin transport
AW19_1403	COG3122	Protein conserved in bacteria
AW19_1404	COG0776	regulation of translation
AW19_1408	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AW19_1409	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AW19_141	COG1061	Type III restriction enzyme res subunit
AW19_1410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AW19_1413	COG3328	transposase activity
AW19_1414	COG1811	Na channel or pump
AW19_1421	COG0803	Belongs to the bacterial solute-binding protein 9 family
AW19_1422	COG1121	(ABC) transporter
AW19_1423	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AW19_1424	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AW19_1427	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AW19_1428	COG1917	Cupin 2, conserved barrel domain protein
AW19_1429	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AW19_1430	COG1028	Short-chain dehydrogenase reductase Sdr
AW19_1432	COG1175	transmembrane transport
AW19_1433	COG0395	ABC-type sugar transport system, permease component
AW19_1434	COG3842	ATPase activity
AW19_1435	COG1653	transport
AW19_1436	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AW19_1437	COG1988	membrane-bound metal-dependent
AW19_1439	COG3023	N-Acetylmuramoyl-L-alanine amidase
AW19_144	COG0582	viral genome integration into host DNA
AW19_1441	COG0823	Involved in the tonB-independent uptake of proteins
AW19_1442	COG2814	Major facilitator Superfamily
AW19_1444	COG0501	Belongs to the peptidase M48B family
AW19_1445	COG0793	Belongs to the peptidase S41A family
AW19_1447	COG1956	GAF domain-containing protein
AW19_1448	COG2995	paraquat-inducible protein a
AW19_1449	COG3008	intermembrane lipid transfer
AW19_145	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AW19_1451	COG2814	Major facilitator Superfamily
AW19_1458	COG2203	Gaf domain
AW19_1458	COG5001	Diguanylate cyclase
AW19_1458	COG3706	GGDEF domain
AW19_1458	COG4251	negative regulation of phosphorylation
AW19_146	COG2867	negative regulation of translational initiation
AW19_1466	COG0668	transmembrane transport
AW19_1472	COG0786	glutamate:sodium symporter activity
AW19_1473	COG1187	pseudouridine synthase activity
AW19_1476	COG3077	Addiction module antitoxin, RelB DinJ family
AW19_1477	COG2026	Addiction module toxin, RelE StbE family
AW19_148	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AW19_1481	COG1276	copper resistance
AW19_1482	COG2372	response to copper ion
AW19_1483	COG1528	Iron-storage protein
AW19_1487	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AW19_1488	COG1770	oligopeptidase
AW19_149	COG0497	DNA recombination
AW19_1491	COG3141	response to X-ray
AW19_1492	COG0513	Belongs to the DEAD box helicase family
AW19_1493	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AW19_1494	COG3140	Belongs to the UPF0181 family
AW19_1496	COG0494	nUDIX hydrolase
AW19_1497	COG1760	l-serine dehydratase
AW19_1499	COG1253	flavin adenine dinucleotide binding
AW19_150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AW19_1500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW19_1500	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW19_1501	COG3715	PTS system
AW19_1502	COG3716	PTS system mannose fructose sorbose family IID component
AW19_1503	COG4811	Protein of unknown function (DUF986)
AW19_1504	COG1971	Probably functions as a manganese efflux pump
AW19_1506	COG5001	Diguanylate cyclase
AW19_1506	COG3447	MASE1 domain protein
AW19_1506	COG5002	protein histidine kinase activity
AW19_1508	COG2226	methyltransferase
AW19_1509	COG0768	penicillin binding
AW19_151	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AW19_1511	COG1278	Cold shock
AW19_1513	COG1113	amino acid transport
AW19_152	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AW19_1520	COG2207	Transcriptional regulator
AW19_1525	COG1132	(ABC) transporter
AW19_1527	COG4251	negative regulation of phosphorylation
AW19_1527	COG3706	GGDEF domain
AW19_1527	COG5001	Diguanylate cyclase
AW19_1527	COG2203	Gaf domain
AW19_1529	COG3755	Protein conserved in bacteria
AW19_153	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AW19_1532	COG1733	regulation of RNA biosynthetic process
AW19_1533	COG0702	epimerase
AW19_1534	COG2873	o-acetylhomoserine
AW19_1536	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AW19_1537	COG0840	transmembrane signaling receptor activity
AW19_154	COG0513	Belongs to the DEAD box helicase family
AW19_1544	COG0538	isocitrate dehydrogenase activity
AW19_1545	COG1187	pseudouridine synthase activity
AW19_1547	COG0482	sulfurtransferase activity
AW19_1548	COG2915	High frequency lysogenization protein hflD homolog
AW19_1549	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AW19_155	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AW19_1551	COG0745	RESPONSE REGULATOR receiver
AW19_1553	COG2850	peptidyl-arginine hydroxylation
AW19_1555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AW19_1556	COG1940	carbohydrate kinase activity
AW19_1557	COG4591	ABC-type transport system involved in lipoprotein release permease component
AW19_1559	COG4591	ABC-type transport system involved in lipoprotein release permease component
AW19_156	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AW19_1560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AW19_1561	COG3134	Outer membrane lipoprotein
AW19_1563	COG1252	NADH dehydrogenase
AW19_1564	COG3150	esterase
AW19_1565	COG1472	Belongs to the glycosyl hydrolase 3 family
AW19_1566	COG0510	thiamine kinase activity
AW19_1567	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
AW19_1568	COG5633	Lipoprotein
AW19_1569	COG0537	adenosine 5'-monophosphoramidase activity
AW19_1570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AW19_1573	COG0641	radical SAM
AW19_1577	COG1263	PTS System
AW19_1577	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW19_1578	COG0084	hydrolase, TatD family'
AW19_1579	COG0470	DNA polymerase III
AW19_158	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AW19_1580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AW19_1581	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AW19_1582	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AW19_1583	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AW19_1585	COG1028	Short-chain dehydrogenase reductase Sdr
AW19_1586	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AW19_1588	COG0416	fatty acid biosynthetic process
AW19_1589	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AW19_1590	COG1399	metal-binding, possibly nucleic acid-binding protein
AW19_1592	COG0564	pseudouridine synthase activity
AW19_1594	COG1530	ribonuclease E activity
AW19_1594	COG1530	ribonuclease E activity
AW19_1595	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AW19_1596	COG0418	dihydroorotase activity
AW19_160	COG3086	response to oxidative stress
AW19_1602	COG0628	permease
AW19_1605	COG1560	Kdo2-lipid A biosynthetic process
AW19_1607	COG2259	Doxx family
AW19_1608	COG2814	Major facilitator Superfamily
AW19_1609	COG3104	oligopeptide transport
AW19_1612	COG5645	(Lipo)protein
AW19_1613	COG2943	transferase activity, transferring hexosyl groups
AW19_1614	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AW19_1617	COG3263	regulation of cellular component size
AW19_162	COG0481	GTPase activity
AW19_1620	COG4235	cytochrome complex assembly
AW19_1621	COG4235	cytochrome complex assembly
AW19_1621	COG3088	subunit of a heme lyase
AW19_1622	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW19_1623	COG1138	Cytochrome C-type biogenesis protein
AW19_1624	COG3301	Polysulphide reductase, NrfD
AW19_1625	COG0437	4 iron, 4 sulfur cluster binding
AW19_1626	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AW19_163	COG0681	Belongs to the peptidase S26 family
AW19_1635	COG1203	CRISPR-associated helicase, Cas3
AW19_1636	COG1518	maintenance of DNA repeat elements
AW19_1638	COG2920	part of a sulfur-relay system
AW19_1639	COG1254	Belongs to the acylphosphatase family
AW19_1641	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AW19_1642	COG3785	DNA binding
AW19_1643	COG1832	CoA-binding protein
AW19_1644	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AW19_1647	COG0210	DNA helicase
AW19_1648	COG3304	Inner membrane component domain
AW19_1649	COG1289	transmembrane transporter activity
AW19_165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AW19_1650	COG3070	regulator of competence-specific genes
AW19_1651	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
AW19_1652	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AW19_1652	COG2885	chlorophyll binding
AW19_1653	COG3120	sequence-specific DNA binding
AW19_1654	COG1067	ATP-dependent peptidase activity
AW19_1655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AW19_1657	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AW19_1658	COG3130	regulation of translation
AW19_1659	COG3009	Protein conserved in bacteria
AW19_166	COG1381	Involved in DNA repair and RecF pathway recombination
AW19_1660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AW19_1660	COG3008	intermembrane lipid transfer
AW19_1661	COG2995	paraquat-inducible protein a
AW19_1662	COG0488	(ABC) transporter
AW19_1663	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AW19_1663	COG0116	Belongs to the methyltransferase superfamily
AW19_1664	COG0633	Ferredoxin
AW19_1664	COG3217	Mosc domain protein beta barrel domain protein
AW19_1666	COG0167	dihydroorotate dehydrogenase activity
AW19_1667	COG0308	aminopeptidase N
AW19_1668	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AW19_1669	COG0017	Asparaginyl-tRNA synthetase
AW19_167	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AW19_1671	COG1448	Aminotransferase
AW19_1672	COG2200	EAL domain
AW19_1673	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW19_1674	COG3108	Peptidase M15
AW19_1675	COG2989	Protein conserved in bacteria
AW19_1676	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AW19_1677	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AW19_1678	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AW19_1679	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AW19_168	COG0736	holo-[acyl-carrier-protein] synthase activity
AW19_1680	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AW19_1681	COG3173	Aminoglycoside phosphotransferase
AW19_1682	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AW19_1683	COG2835	tetraacyldisaccharide 4'-kinase activity
AW19_1684	COG1278	Cold shock
AW19_1685	COG5383	Protein conserved in bacteria
AW19_1686	COG1663	tetraacyldisaccharide 4'-kinase activity
AW19_1688	COG0658	competence protein
AW19_1688	COG2333	competence protein COMEC
AW19_169	COG2610	gluconate transmembrane transporter activity
AW19_1691	COG0539	negative regulation of cytoplasmic translation
AW19_1692	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AW19_1693	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AW19_1695	COG2323	membrane
AW19_1696	COG0252	asparaginase activity
AW19_1697	COG1944	ATP diphosphatase activity
AW19_1698	COG2116	formate transmembrane transporter activity
AW19_1699	COG1882	Formate acetyltransferase
AW19_170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AW19_1700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AW19_1701	COG2814	Major facilitator Superfamily
AW19_1702	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AW19_1703	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AW19_1704	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AW19_1705	COG3107	peptidoglycan biosynthetic process
AW19_1705	COG1674	ftsk spoiiie
AW19_1706	COG1522	sequence-specific DNA binding
AW19_1708	COG0492	ferredoxin-NADP+ reductase activity
AW19_171	COG1737	Transcriptional regulator
AW19_1711	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AW19_1712	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AW19_1713	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AW19_1714	COG0542	response to heat
AW19_1715	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AW19_1716	COG1278	Cold shock
AW19_1718	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AW19_1719	COG2990	Protein conserved in bacteria
AW19_1720	COG3593	DNA synthesis involved in DNA repair
AW19_1721	COG2431	L-lysine efflux transmembrane transporter activity
AW19_1722	COG1151	hydroxylamine reductase activity
AW19_1723	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AW19_1724	COG0028	Belongs to the TPP enzyme family
AW19_1726	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AW19_1727	COG0702	epimerase
AW19_1728	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW19_1730	COG1126	abc transporter atp-binding protein
AW19_1731	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW19_1732	COG4215	(ABC) transporter
AW19_1733	COG4160	amino acid transport
AW19_1734	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW19_1735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AW19_1737	COG1177	transmembrane transport
AW19_1738	COG1176	ABC-type spermidine putrescine transport system, permease component I
AW19_1739	COG3842	ATPase activity
AW19_1740	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AW19_1743	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AW19_1744	COG0569	domain protein
AW19_1744	COG2985	domain, Protein
AW19_1746	COG0671	phosphoesterase, PA-phosphatase related
AW19_1747	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AW19_1748	COG1349	DNA-binding transcription factor activity
AW19_1749	COG0814	amino acid
AW19_175	COG0560	Phosphoserine phosphatase
AW19_1750	COG1760	l-serine dehydratase
AW19_1751	COG1686	Belongs to the peptidase S11 family
AW19_1753	COG0626	cystathionine gamma-synthase activity
AW19_1756	COG2011	ABC-type metal ion transport system permease component
AW19_1762	COG0625	glutathione transferase activity
AW19_1763	COG4771	TonB-dependent receptor
AW19_1764	COG4139	cobalamin transport
AW19_1765	COG0833	amino acid
AW19_1766	COG0583	DNA-binding transcription factor activity
AW19_177	COG0590	tRNA wobble adenosine to inosine editing
AW19_1770	COG2855	membrane
AW19_1771	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AW19_1772	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AW19_1772	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AW19_1772	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AW19_1773	COG1105	Belongs to the carbohydrate kinase PfkB family
AW19_1779	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AW19_178	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AW19_1780	COG1312	Catalyzes the dehydration of D-mannonate
AW19_1781	COG0246	Mannitol dehydrogenase
AW19_1782	COG2186	Transcriptional regulator
AW19_1784	COG0523	cobalamin synthesis protein
AW19_1785	COG0791	NLP P60 protein
AW19_1786	COG2200	EAL domain
AW19_1787	COG4166	transmembrane transport
AW19_1788	COG4174	ABC transporter (Permease)
AW19_1789	COG4239	(ABC) transporter, permease
AW19_1790	COG4172	Belongs to the ABC transporter superfamily
AW19_1792	COG2814	Major facilitator Superfamily
AW19_1793	COG1187	pseudouridine synthase activity
AW19_1794	COG1061	Type III restriction enzyme res subunit
AW19_1796	COG3081	Nucleoid-associated protein
AW19_1797	COG3082	Protein of unknown function (DUF1414)
AW19_1800	COG2723	6-phospho-beta-galactosidase activity
AW19_1801	COG2190	(PTS) system
AW19_1801	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW19_1801	COG1263	PTS System
AW19_1809	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AW19_181	COG2205	protein histidine kinase activity
AW19_1812	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AW19_1814	COG1132	(ABC) transporter
AW19_1817	COG2223	nitrite transmembrane transporter activity
AW19_1818	COG2198	Histidine kinase
AW19_1818	COG0642	Histidine kinase
AW19_182	COG3170	Tfp pilus assembly protein FimV
AW19_1820	COG0784	Response regulator, receiver
AW19_1820	COG2205	protein histidine kinase activity
AW19_1822	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AW19_1823	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AW19_1825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AW19_1826	COG4574	serine-type endopeptidase inhibitor activity
AW19_1828	COG0814	amino acid
AW19_183	COG2204	response regulator
AW19_1832	COG1441	menaquinone biosynthetic process
AW19_1833	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AW19_1834	COG0596	Alpha beta hydrolase
AW19_1835	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AW19_1836	COG1169	isochorismate synthase
AW19_1838	COG4575	ribosome binding
AW19_1839	COG0129	dihydroxy-acid dehydratase activity
AW19_184	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AW19_184	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AW19_1840	COG4702	Belongs to the UPF0303 family
AW19_1842	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AW19_1843	COG1609	Transcriptional regulator
AW19_1844	COG1028	Short-chain dehydrogenase reductase Sdr
AW19_1845	COG3265	gluconokinase activity
AW19_1846	COG2731	YhcH YjgK YiaL family protein
AW19_1849	COG1007	ATP synthesis coupled electron transport
AW19_185	COG0347	Belongs to the P(II) protein family
AW19_1850	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AW19_1851	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AW19_1852	COG0713	ATP synthesis coupled electron transport
AW19_1853	COG0839	Belongs to the complex I subunit 6 family
AW19_1854	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AW19_1855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AW19_1856	COG1034	ATP synthesis coupled electron transport
AW19_1858	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AW19_1859	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AW19_1859	COG0649	NAD binding
AW19_1860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AW19_1862	COG0583	DNA-binding transcription factor activity
AW19_1863	COG0436	Aminotransferase
AW19_1865	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AW19_1866	COG0471	metal ion transport
AW19_1866	COG0490	domain, Protein
AW19_1868	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AW19_1869	COG3013	Belongs to the UPF0304 family
AW19_187	COG2188	Transcriptional regulator
AW19_1870	COG3092	negative regulation of chromosome organization
AW19_1872	COG0857	belongs to the CobB CobQ family
AW19_1872	COG0280	phosphate acetyltransferase
AW19_1873	COG1609	Transcriptional regulator
AW19_1876	COG3037	sugar-specific permease SgaT UlaA
AW19_1877	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AW19_1878	COG0622	Phosphoesterase
AW19_188	COG1017	nitric oxide dioxygenase activity
AW19_188	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AW19_1880	COG1090	epimerase
AW19_1881	COG4598	ABC transporter
AW19_1882	COG4160	amino acid transport
AW19_1883	COG4215	(ABC) transporter
AW19_1884	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW19_1885	COG0163	prenyltransferase activity
AW19_1886	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AW19_1887	COG1286	toxin biosynthetic process
AW19_1888	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AW19_189	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AW19_1890	COG0285	dihydrofolate synthase activity
AW19_1893	COG0586	Pfam SNARE associated Golgi protein
AW19_1896	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AW19_1897	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AW19_1898	COG2207	Transcriptional regulator
AW19_1899	COG0697	spore germination
AW19_190	COG3711	transcriptional antiterminator
AW19_1901	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW19_1902	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW19_1904	COG4232	protein-disulfide reductase activity
AW19_1906	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AW19_1908	COG1609	Transcriptional regulator
AW19_191	COG2814	Major facilitator Superfamily
AW19_1910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AW19_1911	COG2723	6-phospho-beta-galactosidase activity
AW19_1912	COG1447	Phosphotransferase system cellobiose-specific component IIA
AW19_1914	COG1794	racemase activity, acting on amino acids and derivatives
AW19_1915	COG3706	GGDEF domain
AW19_1916	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AW19_1917	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AW19_1917	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AW19_1919	COG3101	peptidyl-lysine hydroxylation
AW19_192	COG3683	transport system, periplasmic component
AW19_1920	COG0730	response to heat
AW19_1921	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AW19_1922	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AW19_1923	COG2890	protein-(glutamine-N5) methyltransferase activity
AW19_1924	COG2840	Smr protein MutS2
AW19_1925	COG2062	phosphohistidine phosphatase, SixA
AW19_1926	COG1024	Enoyl-CoA hydratase
AW19_1926	COG1250	3-hydroxyacyl-CoA dehydrogenase
AW19_1927	COG0183	Belongs to the thiolase family
AW19_1928	COG3691	Protein conserved in bacteria
AW19_193	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AW19_1931	COG4235	cytochrome complex assembly
AW19_1931	COG3088	subunit of a heme lyase
AW19_1932	COG3088	subunit of a heme lyase
AW19_1932	COG4235	cytochrome complex assembly
AW19_1933	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW19_1934	COG1138	Cytochrome C-type biogenesis protein
AW19_1935	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AW19_1936	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AW19_1937	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AW19_1938	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AW19_194	COG0483	inositol monophosphate 1-phosphatase activity
AW19_1940	COG2116	formate transmembrane transporter activity
AW19_1942	COG0582	viral genome integration into host DNA
AW19_195	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AW19_196	COG1959	2 iron, 2 sulfur cluster binding
AW19_1974	COG3728	DNA packaging
AW19_1979	COG3772	lysozyme
AW19_198	COG0822	iron-sulfur transferase activity
AW19_1992	COG0305	Participates in initiation and elongation during chromosome replication
AW19_2009	COG3723	Recombinational DNA repair protein, rece pathway
AW19_201	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AW19_202	COG0443	Heat shock 70 kDa protein
AW19_2021	COG0582	viral genome integration into host DNA
AW19_2023	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AW19_2024	COG2501	S4 domain
AW19_2025	COG0215	cysteine-tRNA ligase activity
AW19_2026	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AW19_2027	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AW19_2028	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AW19_2029	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AW19_203	COG0633	Ferredoxin
AW19_2030	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AW19_2031	COG4181	ATPase activity
AW19_2032	COG2755	lipolytic protein G-D-S-L family
AW19_2033	COG0300	oxidoreductase activity
AW19_2034	COG3118	belongs to the thioredoxin family
AW19_2035	COG0330	HflC and HflK could
AW19_2036	COG1585	Membrane protein implicated in regulation of membrane protease activity
AW19_2037	COG0789	Transcriptional regulator
AW19_2038	COG2217	Heavy metal translocating P-type atpase
AW19_2039	COG3735	TraB family
AW19_204	COG2975	iron-sulfur cluster assembly
AW19_2040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AW19_2041	COG0737	Belongs to the 5'-nucleotidase family
AW19_2042	COG2223	nitrite transmembrane transporter activity
AW19_2043	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AW19_2043	COG4651	solute:proton antiporter activity
AW19_2044	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AW19_2048	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AW19_2049	COG0438	transferase activity, transferring glycosyl groups
AW19_2050	COG0438	transferase activity, transferring glycosyl groups
AW19_2051	COG1215	transferase activity, transferring glycosyl groups
AW19_2052	COG1442	glycosyl transferase family 8
AW19_2052	COG1216	Glycosyl transferase, family 2
AW19_2053	COG2244	polysaccharide biosynthetic process
AW19_2054	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AW19_2055	COG0563	adenylate kinase activity
AW19_2056	COG0326	Molecular chaperone. Has ATPase activity
AW19_2057	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AW19_2058	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AW19_2059	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AW19_2060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AW19_2061	COG2832	Protein of unknown function (DUF454)
AW19_2063	COG3264	Mechanosensitive ion channel
AW19_2063	COG1196	nuclear chromosome segregation
AW19_2064	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AW19_2065	COG1309	transcriptional regulator
AW19_2066	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AW19_2067	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AW19_2069	COG3457	Alanine racemase
AW19_207	COG3468	outer membrane autotransporter barrel domain protein
AW19_2070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AW19_2073	COG0254	rRNA binding
AW19_2074	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AW19_2075	COG0803	Belongs to the bacterial solute-binding protein 9 family
AW19_2076	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AW19_2077	COG1121	(ABC) transporter
AW19_208	COG2373	Large extracellular alpha-helical protein
AW19_2081	COG3695	enzyme binding
AW19_2082	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AW19_2083	COG1946	Acyl-CoA thioesterase
AW19_2084	COG0004	ammonium transporteR
AW19_2085	COG0347	Belongs to the P(II) protein family
AW19_2086	COG1132	(ABC) transporter
AW19_2087	COG1132	(ABC) transporter
AW19_2088	COG1522	sequence-specific DNA binding
AW19_209	COG4953	penicillin-binding protein 1C
AW19_2090	COG0561	phosphatase activity
AW19_2091	COG4533	DNA binding
AW19_2092	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AW19_2093	COG0824	Thioesterase
AW19_2094	COG1555	photosystem II stabilization
AW19_2095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AW19_2097	COG0776	regulation of translation
AW19_2098	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AW19_2099	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AW19_21	COG0410	ABC transporter
AW19_2101	COG0544	peptidyl-prolyl cis-trans isomerase activity
AW19_2102	COG0271	Belongs to the BolA IbaG family
AW19_2103	COG3056	Lipoprotein
AW19_2104	COG2223	nitrite transmembrane transporter activity
AW19_2106	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AW19_2107	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AW19_2108	COG1845	cytochrome c oxidase, subunit III
AW19_2109	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AW19_2110	COG0109	protoheme IX farnesyltransferase activity
AW19_2111	COG2814	Major facilitator Superfamily
AW19_2112	COG1666	GTP binding
AW19_2113	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AW19_2114	COG0693	protein deglycase activity
AW19_2115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AW19_2115	COG0301	tRNA thio-modification
AW19_2116	COG1722	exodeoxyribonuclease VII activity
AW19_2117	COG0142	geranyltranstransferase activity
AW19_2118	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AW19_2119	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AW19_212	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AW19_2120	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AW19_2121	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AW19_2122	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AW19_2123	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AW19_2123	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AW19_2126	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AW19_2127	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AW19_2128	COG1862	Preprotein translocase
AW19_2129	COG0343	queuine tRNA-ribosyltransferase activity
AW19_2133	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AW19_2134	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AW19_2135	COG0450	alkyl hydroperoxide reductase
AW19_2138	COG0366	Alpha amylase catalytic
AW19_2140	COG1114	Component of the transport system for branched-chain amino acids
AW19_2142	COG5002	protein histidine kinase activity
AW19_2143	COG0745	RESPONSE REGULATOR receiver
AW19_2145	COG0420	3'-5' exonuclease activity
AW19_2146	COG0419	ATPase involved in DNA repair
AW19_2147	COG1940	carbohydrate kinase activity
AW19_2148	COG2974	May be involved in recombination
AW19_2149	COG3123	guanosine phosphorylase activity
AW19_2150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AW19_2157	COG2226	methyltransferase
AW19_216	COG0124	histidyl-tRNA synthetase
AW19_2160	COG3459	Glycosyltransferase 36 associated
AW19_2164	COG2188	Transcriptional regulator
AW19_2165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW19_2166	COG2313	pseudouridylate synthase activity
AW19_2167	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AW19_2168	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AW19_217	COG2976	Protein conserved in bacteria
AW19_2170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AW19_2173	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AW19_2175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AW19_2178	COG0438	transferase activity, transferring glycosyl groups
AW19_218	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AW19_2183	COG1086	Polysaccharide biosynthesis protein
AW19_2187	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
AW19_2188	COG2195	Cleaves the N-terminal amino acid of tripeptides
AW19_2189	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AW19_219	COG1160	GTP binding
AW19_2192	COG2964	Protein conserved in bacteria
AW19_2193	COG1181	Belongs to the D-alanine--D-alanine ligase family
AW19_2196	COG2991	Protein conserved in bacteria
AW19_2197	COG1477	protein flavinylation
AW19_2198	COG2871	sodium ion transport
AW19_2199	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AW19_22	COG1137	ATPase activity
AW19_2200	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AW19_2201	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AW19_2202	COG1805	sodium ion transport
AW19_2203	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AW19_2204	COG0121	glutamine amidotransferase
AW19_2205	COG3034	peptidoglycan biosynthetic process
AW19_2206	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AW19_2207	COG1960	acyl-CoA dehydrogenase activity
AW19_2208	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AW19_2209	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AW19_221	COG1645	bacterial-type flagellum-dependent swarming motility
AW19_2210	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AW19_2211	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AW19_2212	COG0235	Class ii aldolase
AW19_2213	COG0436	Aminotransferase
AW19_2215	COG2814	Major facilitator Superfamily
AW19_2216	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AW19_2218	COG1846	Transcriptional regulator
AW19_2219	COG1566	PFAM secretion protein HlyD family protein
AW19_222	COG1570	exodeoxyribonuclease VII activity
AW19_2220	COG2814	Major facilitator Superfamily
AW19_2221	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AW19_2222	COG3118	belongs to the thioredoxin family
AW19_2224	COG0045	succinate-CoA ligase (ADP-forming) activity
AW19_2224	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW19_2224	COG1042	CoA-binding domain protein
AW19_2225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AW19_2226	COG5544	Lipoprotein
AW19_223	COG0516	GMP reductase activity
AW19_223	COG0517	IMP dehydrogenase activity
AW19_2232	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AW19_2234	COG2011	ABC-type metal ion transport system permease component
AW19_2235	COG1464	Belongs to the NlpA lipoprotein family
AW19_2237	COG1720	tRNA m6t6A37 methyltransferase activity
AW19_2238	COG0442	prolyl-tRNA aminoacylation
AW19_2239	COG3015	lipoprotein NlpE involved in copper resistance
AW19_224	COG0519	Catalyzes the synthesis of GMP from XMP
AW19_224	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AW19_2241	COG4681	YaeQ
AW19_2243	COG4568	rho-dependent transcription termination
AW19_2245	COG0037	tRNA processing
AW19_2246	COG0346	lactoylglutathione lyase activity
AW19_225	COG0582	viral genome integration into host DNA
AW19_2250	COG0825	malonyl-CoA metabolic process
AW19_2251	COG0587	DNA-directed DNA polymerase activity
AW19_2252	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AW19_2253	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AW19_2254	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AW19_2255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AW19_2256	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AW19_2257	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AW19_2259	COG0750	zinc metalloprotease
AW19_2260	COG0575	Belongs to the CDS family
AW19_2261	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AW19_2262	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AW19_2263	COG0233	cytoplasmic translational termination
AW19_2264	COG0528	UMP kinase activity
AW19_2265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AW19_2266	COG0052	Belongs to the universal ribosomal protein uS2 family
AW19_2267	COG0024	Methionine aminopeptidase
AW19_2268	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AW19_2269	COG2171	N-acyltransferase activity
AW19_2272	COG0564	pseudouridine synthase activity
AW19_2273	COG3098	single-species biofilm formation
AW19_2275	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AW19_2275	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AW19_2276	COG1611	Belongs to the LOG family
AW19_2277	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW19_2278	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AW19_2279	COG2363	Small membrane protein
AW19_2280	COG0583	DNA-binding transcription factor activity
AW19_2282	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AW19_2283	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AW19_2284	COG2166	iron-sulfur cluster assembly
AW19_2285	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AW19_2289	COG0860	N-Acetylmuramoyl-L-alanine amidase
AW19_2290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AW19_2290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AW19_2291	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AW19_2292	COG1074	ATP-dependent DNA helicase activity
AW19_2293	COG1025	Belongs to the peptidase M16 family
AW19_2294	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AW19_2295	COG4967	type IV pilus modification protein PilV
AW19_2299	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AW19_23	COG4177	L-phenylalanine transmembrane transporter activity
AW19_2300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AW19_2302	COG1051	belongs to the nudix hydrolase family
AW19_2303	COG3066	DNA modification
AW19_2304	COG0861	Integral membrane protein TerC family
AW19_2305	COG0667	Aldo Keto reductase
AW19_2306	COG0477	Major facilitator Superfamily
AW19_2307	COG0204	Acyl-transferase
AW19_2307	COG0318	PFAM AMP-dependent synthetase and ligase
AW19_2309	COG1609	Transcriptional regulator
AW19_2310	COG0019	diaminopimelate decarboxylase activity
AW19_2311	COG0583	DNA-binding transcription factor activity
AW19_2312	COG2814	Major facilitator Superfamily
AW19_2313	COG0583	DNA-binding transcription factor activity
AW19_2317	COG0840	transmembrane signaling receptor activity
AW19_2327	COG2165	general secretion pathway protein
AW19_2329	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AW19_2333	COG0288	reversible hydration of carbon dioxide
AW19_2334	COG1733	regulation of RNA biosynthetic process
AW19_2335	COG1028	Short-chain dehydrogenase reductase Sdr
AW19_2337	COG0484	heat shock protein binding
AW19_2338	COG1609	Transcriptional regulator
AW19_2339	COG2271	Major facilitator Superfamily
AW19_2342	COG1522	sequence-specific DNA binding
AW19_2361	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AW19_2363	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AW19_2364	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AW19_2365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AW19_2366	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AW19_2367	COG4974	Belongs to the 'phage' integrase family
AW19_2368	COG0716	FMN binding
AW19_2369	COG4452	Inner membrane protein CreD
AW19_2370	COG2205	protein histidine kinase activity
AW19_2371	COG0745	RESPONSE REGULATOR receiver
AW19_2373	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AW19_2374	COG0354	folic acid binding
AW19_2375	COG1272	protein, Hemolysin III
AW19_2377	COG1028	Short-chain dehydrogenase reductase Sdr
AW19_2378	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AW19_2378	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AW19_2379	COG0509	glycine decarboxylation via glycine cleavage system
AW19_2380	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AW19_2381	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AW19_2382	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AW19_2383	COG0006	proline dipeptidase activity
AW19_2384	COG3079	Belongs to the UPF0149 family
AW19_2385	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AW19_2386	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AW19_2387	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AW19_2388	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AW19_2389	COG0583	DNA-binding transcription factor activity
AW19_2391	COG1279	arginine transmembrane transporter activity
AW19_2394	COG0191	fructose-bisphosphate aldolase activity
AW19_2395	COG0126	phosphoglycerate kinase activity
AW19_2396	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AW19_2397	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AW19_2398	COG0501	Belongs to the peptidase M48B family
AW19_24	COG0559	Belongs to the binding-protein-dependent transport system permease family
AW19_2400	COG1166	arginine decarboxylase activity
AW19_2401	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AW19_2405	COG0640	Transcriptional regulator
AW19_2406	COG3091	SprT-like family
AW19_2407	COG2356	endonuclease I
AW19_2408	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AW19_2409	COG0189	ligase activity
AW19_2410	COG1678	Uncharacterized ACR, COG1678
AW19_2411	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AW19_2412	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AW19_2414	COG2805	Type II/IV secretion system protein
AW19_2415	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AW19_2416	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AW19_2417	COG0762	integral membrane protein
AW19_2418	COG1872	DUF167
AW19_2419	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AW19_2420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AW19_2422	COG2066	Belongs to the glutaminase family
AW19_2423	COG3171	Protein conserved in bacteria
AW19_2424	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AW19_2425	COG1194	a g-specific adenine glycosylase
AW19_2426	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AW19_2427	COG0741	lytic transglycosylase activity
AW19_2429	COG1982	Orn Lys Arg decarboxylase major
AW19_2431	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AW19_2435	COG0305	Participates in initiation and elongation during chromosome replication
AW19_2437	COG0582	viral genome integration into host DNA
AW19_244	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AW19_2442	COG0210	DNA helicase
AW19_2466	COG3047	cAMP biosynthetic process
AW19_2466	COG2885	chlorophyll binding
AW19_2472	COG2040	homocysteine
AW19_2482	COG2211	Major facilitator Superfamily
AW19_2489	COG0656	L-ascorbic acid biosynthetic process
AW19_2490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AW19_2492	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AW19_2494	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AW19_2514	COG3179	chitinase
AW19_2521	COG3179	chitinase
AW19_2525	COG2885	chlorophyll binding
AW19_2532	COG1289	transmembrane transporter activity
AW19_2537	COG0024	Methionine aminopeptidase
AW19_2538	COG4604	ABC transporter, ATP-binding protein
AW19_2539	COG4605	iron ion homeostasis
AW19_2541	COG4607	ABC-type enterochelin transport system periplasmic component
AW19_2544	COG0477	Major facilitator Superfamily
AW19_2548	COG1283	sodium-dependent phosphate transmembrane transporter activity
AW19_2549	COG2195	Cleaves the N-terminal amino acid of tripeptides
AW19_2550	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AW19_2555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AW19_2556	COG5001	Diguanylate cyclase
AW19_2558	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AW19_2559	COG0309	Hydrogenase expression formation protein (HypE)
AW19_2560	COG0409	Hydrogenase expression formation protein
AW19_2561	COG0298	carbon dioxide binding
AW19_2562	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AW19_2563	COG0375	protein maturation
AW19_2564	COG1773	rubredoxin
AW19_2565	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AW19_2566	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AW19_2567	COG5557	Pfam Polysulphide reductase, NrfD
AW19_2568	COG0437	4 iron, 4 sulfur cluster binding
AW19_2569	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AW19_2570	COG3133	Outer membrane lipoprotein
AW19_2572	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AW19_2573	COG1191	sigma factor activity
AW19_2577	COG1516	flagellar protein fliS
AW19_2578	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AW19_2579	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AW19_2580	COG3710	Transcriptional regulator
AW19_2583	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AW19_2586	COG1706	bacterial-type flagellum-dependent cell motility
AW19_2588	COG4786	Flagellar basal body rod
AW19_2591	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AW19_2592	COG1558	bacterial-type flagellum-dependent cell motility
AW19_2593	COG1815	bacterial-type flagellum-dependent cell motility
AW19_26	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AW19_26	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AW19_2602	COG1677	Flagellar hook-basal body complex protein FliE
AW19_2603	COG2204	response regulator
AW19_2607	COG1987	bacterial-type flagellum assembly
AW19_2609	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AW19_2612	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW19_2613	COG2271	Major facilitator Superfamily
AW19_2614	COG1028	Short-chain dehydrogenase reductase Sdr
AW19_2615	COG1535	isochorismatase
AW19_2615	COG3433	isochorismatase activity
AW19_2616	COG1021	2,3-dihydroxybenzoate-AMP ligase
AW19_2617	COG1169	isochorismate synthase
AW19_2618	COG4592	Periplasmic binding protein
AW19_2619	COG1120	ATPase activity
AW19_2620	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW19_2621	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW19_2624	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AW19_2627	COG4774	siderophore transport
AW19_2631	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AW19_2632	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AW19_2638	COG4964	Belongs to the GSP D family
AW19_2648	COG0848	biopolymer transport protein
AW19_2649	COG0811	peptide transport
AW19_2651	COG0586	Pfam SNARE associated Golgi protein
AW19_2652	COG2207	Transcriptional regulator
AW19_2653	COG1979	alcohol dehydrogenase
AW19_2654	COG0656	L-ascorbic acid biosynthetic process
AW19_2656	COG2132	Multicopper oxidase
AW19_2657	COG0204	Acyl-transferase
AW19_2659	COG2249	NAD(P)H dehydrogenase (quinone) activity
AW19_2660	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AW19_2661	COG0583	DNA-binding transcription factor activity
AW19_2662	COG0187	DNA topoisomerase II activity
AW19_2663	COG3150	esterase
AW19_2664	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AW19_2665	COG3151	Protein conserved in bacteria
AW19_2666	COG0494	nUDIX hydrolase
AW19_2667	COG1538	Outer membrane efflux protein
AW19_2668	COG5463	Belongs to the UPF0441 family
AW19_2669	COG0754	glutathionylspermidine amidase activity
AW19_2670	COG3384	dioxygenase
AW19_2671	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AW19_2673	COG0531	amino acid
AW19_2674	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AW19_2674	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AW19_2675	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AW19_2676	COG3025	triphosphatase activity
AW19_2677	COG4991	sh3 domain protein
AW19_2678	COG0617	tRNA 3'-terminal CCA addition
AW19_2679	COG1968	undecaprenyl-diphosphatase activity
AW19_2680	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AW19_2681	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AW19_2682	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AW19_2685	COG0358	DNA primase activity
AW19_2686	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AW19_2688	COG3876	Protein conserved in bacteria
AW19_2690	COG1472	Belongs to the glycosyl hydrolase 3 family
AW19_2692	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AW19_2693	COG1263	PTS System
AW19_2693	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW19_2695	COG0531	amino acid
AW19_2696	COG0076	glutamate decarboxylase activity
AW19_2698	COG3247	response to pH
AW19_27	COG0243	molybdopterin cofactor binding
AW19_2700	COG1902	pentaerythritol trinitrate reductase activity
AW19_2700	COG0446	pyridine nucleotide-disulphide oxidoreductase
AW19_2701	COG2813	Specifically methylates the guanine in position
AW19_2703	COG1451	nucleotide metabolic process
AW19_2704	COG0673	inositol 2-dehydrogenase activity
AW19_2705	COG0861	Integral membrane protein TerC family
AW19_2706	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AW19_2708	COG2721	sulfolactate sulfo-lyase activity
AW19_2709	COG0246	Mannitol dehydrogenase
AW19_271	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AW19_2710	COG1904	glucuronate isomerase
AW19_2711	COG2271	Major facilitator Superfamily
AW19_2714	COG0586	Pfam SNARE associated Golgi protein
AW19_2717	COG4575	ribosome binding
AW19_2718	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
AW19_2720	COG2259	Doxx family
AW19_2721	COG0435	Glutathione S-transferase
AW19_2722	COG0583	DNA-binding transcription factor activity
AW19_2723	COG1741	Belongs to the pirin family
AW19_2724	COG1064	alcohol dehydrogenase
AW19_2725	COG4221	oxidoreductase activity
AW19_2727	COG0667	Aldo Keto reductase
AW19_2744	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AW19_2746	COG0792	nuclease activity
AW19_2747	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AW19_2748	COG2823	Periplasmic or secreted lipoprotein
AW19_2749	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AW19_2750	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AW19_2751	COG5002	protein histidine kinase activity
AW19_2751	COG0784	Response regulator, receiver
AW19_2751	COG2198	Histidine kinase
AW19_2752	COG1242	4 iron, 4 sulfur cluster binding
AW19_2753	COG0070	glutamate synthase
AW19_2753	COG0067	glutamate synthase
AW19_2753	COG0069	glutamate synthase activity
AW19_2754	COG0493	'glutamate synthase
AW19_2756	COG2969	positive regulation of protein catabolic process
AW19_2757	COG0625	glutathione transferase activity
AW19_2758	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AW19_2759	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AW19_2760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AW19_2761	COG3105	Protein conserved in bacteria
AW19_2762	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AW19_2763	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AW19_2764	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AW19_2765	COG5007	Belongs to the BolA IbaG family
AW19_2766	COG3113	response to antibiotic
AW19_2767	COG2854	intermembrane phospholipid transfer
AW19_2768	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AW19_2769	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AW19_2770	COG1127	ABC transporter
AW19_2771	COG0530	calcium, potassium:sodium antiporter activity
AW19_2772	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AW19_2772	COG0517	IMP dehydrogenase activity
AW19_2773	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AW19_2774	COG3117	lipopolysaccharide transmembrane transporter activity
AW19_2775	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AW19_2776	COG1137	ATPase activity
AW19_2777	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AW19_2779	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW19_2780	COG1660	Displays ATPase and GTPase activities
AW19_2781	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW19_2783	COG0540	Belongs to the ATCase OTCase family
AW19_2784	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AW19_2786	COG0366	Alpha amylase catalytic
AW19_2787	COG1263	PTS System
AW19_2787	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW19_2789	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AW19_279	COG0351	phosphomethylpyrimidine kinase
AW19_2790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW19_2790	COG3711	transcriptional antiterminator
AW19_2791	COG2706	6-phosphogluconolactonase activity
AW19_2794	COG3964	amidohydrolase
AW19_28	COG0437	4 iron, 4 sulfur cluster binding
AW19_2800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AW19_2801	COG3783	Cytochrome b(562)
AW19_2802	COG0312	modulator of DNA gyrase
AW19_2803	COG3028	Belongs to the UPF0307 family
AW19_2804	COG2732	(Barnase) inhibitor
AW19_2807	COG1289	transmembrane transporter activity
AW19_2808	COG1566	PFAM secretion protein HlyD family protein
AW19_2810	COG0583	DNA-binding transcription factor activity
AW19_2811	COG0312	modulator of DNA gyrase
AW19_2812	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AW19_2813	COG3164	Protein of unknown function
AW19_2814	COG1530	ribonuclease E activity
AW19_2816	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AW19_2817	COG1792	Involved in formation and maintenance of cell shape
AW19_2818	COG1077	Cell shape determining protein MreB Mrl
AW19_2819	COG2200	EAL domain
AW19_2819	COG2199	diguanylate cyclase activity
AW19_2820	COG0604	alcohol dehydrogenase
AW19_2822	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AW19_2823	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AW19_2824	COG0511	ligase activity, forming carbon-carbon bonds
AW19_2825	COG0439	Biotin carboxylase
AW19_2826	COG3924	membrane
AW19_2827	COG4145	pantothenate transmembrane transporter activity
AW19_2828	COG2264	protein methyltransferase activity
AW19_2829	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AW19_283	COG1349	DNA-binding transcription factor activity
AW19_2830	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AW19_2831	COG3706	GGDEF domain
AW19_2832	COG3133	Outer membrane lipoprotein
AW19_2833	COG1278	Cold shock
AW19_2834	COG1278	Cold shock
AW19_2836	COG0471	metal ion transport
AW19_2837	COG1560	Kdo2-lipid A biosynthetic process
AW19_284	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW19_2840	COG1380	Effector of murein hydrolase LrgA
AW19_2841	COG0583	DNA-binding transcription factor activity
AW19_2842	COG0025	NhaP-type Na H and K H
AW19_2843	COG2252	PERMEase
AW19_2849	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AW19_285	COG1028	Short-chain dehydrogenase reductase Sdr
AW19_2850	COG2315	Protein conserved in bacteria
AW19_2851	COG1448	Aminotransferase
AW19_2852	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AW19_2853	COG0305	Participates in initiation and elongation during chromosome replication
AW19_2857	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AW19_2858	COG0735	belongs to the Fur family
AW19_2859	COG3237	CsbD-like
AW19_2860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AW19_2861	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AW19_2862	COG2937	Belongs to the GPAT DAPAT family
AW19_2863	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AW19_2864	COG3161	chorismate lyase activity
AW19_2869	COG2182	Extracellular solute-binding protein
AW19_2870	COG1175	transmembrane transport
AW19_2871	COG3833	ABC-type maltose transport systems, permease component
AW19_2872	COG3223	Belongs to the PsiE family
AW19_2875	COG0527	aspartate kinase activity
AW19_288	COG3730	PTS system glucitol sorbitol-specific
AW19_2880	COG1414	Transcriptional regulator
AW19_2881	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AW19_2882	COG2224	Isocitrate lyase
AW19_2883	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AW19_2884	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AW19_289	COG1597	lipid kinase activity
AW19_2893	COG0138	bifunctional purine biosynthesis protein purh
AW19_2894	COG0151	Belongs to the GarS family
AW19_2897	COG3068	Protein conserved in bacteria
AW19_2898	COG1515	deoxyribonuclease V activity
AW19_2899	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AW19_29	COG3302	dmso reductase anchor subunit
AW19_2900	COG2816	NAD+ diphosphatase activity
AW19_2901	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AW19_2902	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AW19_2904	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AW19_2905	COG2104	thiamine diphosphate biosynthetic process
AW19_2906	COG2022	thiamine diphosphate biosynthetic process
AW19_2907	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AW19_2909	COG0085	RNA polymerase activity
AW19_291	COG3422	double-strand break repair
AW19_2911	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AW19_2912	COG0081	regulation of translation
AW19_2913	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AW19_2914	COG0250	Participates in transcription elongation, termination and antitermination
AW19_2915	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AW19_2916	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AW19_292	COG0745	RESPONSE REGULATOR receiver
AW19_2925	COG1072	(Pantothenic acid kinase))
AW19_293	COG2205	protein histidine kinase activity
AW19_2933	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AW19_2934	COG1739	Uncharacterized protein family UPF0029
AW19_2935	COG0006	proline dipeptidase activity
AW19_2936	COG1250	3-hydroxyacyl-CoA dehydrogenase
AW19_2936	COG1024	Enoyl-CoA hydratase
AW19_2937	COG0183	Belongs to the thiolase family
AW19_2939	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AW19_294	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AW19_2943	COG0805	protein transport
AW19_2944	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AW19_2945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AW19_2946	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AW19_2948	COG2226	methyltransferase
AW19_2949	COG1322	Protein conserved in bacteria
AW19_2950	COG0586	Pfam SNARE associated Golgi protein
AW19_2951	COG1966	Carbon starvation protein
AW19_2953	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AW19_2954	COG0412	Dienelactone hydrolase
AW19_2955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AW19_2957	COG0583	DNA-binding transcription factor activity
AW19_2958	COG0679	Auxin Efflux Carrier
AW19_2959	COG0584	glycerophosphoryl diester phosphodiesterase
AW19_296	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AW19_2960	COG3842	ATPase activity
AW19_2961	COG0395	ABC-type sugar transport system, permease component
AW19_2962	COG1175	transmembrane transport
AW19_2963	COG1653	transport
AW19_2970	COG0410	ABC transporter
AW19_2971	COG0411	ABC transporter
AW19_2972	COG4177	L-phenylalanine transmembrane transporter activity
AW19_2973	COG0559	Belongs to the binding-protein-dependent transport system permease family
AW19_2974	COG0683	leucine binding
AW19_2978	COG2177	Part of the ABC transporter FtsEX involved in
AW19_2979	COG2884	Cell division ATP-binding protein ftsE
AW19_298	COG0443	Heat shock 70 kDa protein
AW19_2980	COG0552	protein localization to endoplasmic reticulum
AW19_2981	COG0742	ribosomal rna small subunit methyltransferase
AW19_2982	COG3776	membrane
AW19_2985	COG3714	YhhN family
AW19_2987	COG0425	Belongs to the sulfur carrier protein TusA family
AW19_2988	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AW19_299	COG3447	MASE1 domain protein
AW19_299	COG5001	Diguanylate cyclase
AW19_299	COG5002	protein histidine kinase activity
AW19_2990	COG0247	lactate metabolic process
AW19_2992	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AW19_2993	COG2271	Major facilitator Superfamily
AW19_2994	COG0584	glycerophosphoryl diester phosphodiesterase
AW19_2995	COG0561	phosphatase activity
AW19_2996	COG2267	carboxylic ester hydrolase activity
AW19_2997	COG1280	lysine exporter protein (LysE YggA)
AW19_2998	COG1280	lysine exporter protein (LysE YggA)
AW19_2999	COG0514	ATP-dependent DNA helicase (RecQ)
AW19_30	COG3381	protein complex oligomerization
AW19_300	COG2239	Acts as a magnesium transporter
AW19_3000	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AW19_3001	COG2050	protein possibly involved in aromatic compounds catabolism
AW19_3003	COG0598	Magnesium transport protein CorA
AW19_3005	COG5564	TIM-barrel signal transduction protein
AW19_3006	COG5441	Belongs to the UPF0261 family
AW19_3008	COG0210	DNA helicase
AW19_3009	COG1011	Hydrolase
AW19_3010	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AW19_3011	COG3159	Protein conserved in bacteria
AW19_3012	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AW19_3013	COG5567	small periplasmic lipoprotein
AW19_3014	COG1965	Belongs to the frataxin family
AW19_3015	COG3072	Adenylate cyclase
AW19_3016	COG0181	hydroxymethylbilane synthase activity
AW19_3017	COG1587	Uroporphyrinogen-III synthase
AW19_3018	COG2959	enzyme of heme biosynthesis
AW19_3019	COG3071	HemY protein
AW19_302	COG0248	Ppx GppA phosphatase
AW19_3026	COG1113	amino acid transport
AW19_3029	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AW19_303	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AW19_3030	COG2244	polysaccharide biosynthetic process
AW19_3031	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AW19_3032	COG0456	acetyltransferase
AW19_3033	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AW19_3034	COG1088	dTDP-glucose 4,6-dehydratase activity
AW19_3035	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AW19_3036	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AW19_3037	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
AW19_3038	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AW19_3039	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AW19_304	COG0573	inorganic phosphate transmembrane transporter activity
AW19_3040	COG3118	belongs to the thioredoxin family
AW19_3042	COG0248	Ppx GppA phosphatase
AW19_3044	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AW19_3046	COG3121	Chaperone
AW19_3049	COG3121	Chaperone
AW19_305	COG0581	inorganic phosphate transmembrane transporter activity
AW19_3055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AW19_3056	COG0583	DNA-binding transcription factor activity
AW19_3057	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AW19_3058	COG0129	dihydroxy-acid dehydratase activity
AW19_3059	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AW19_3060	COG3978	acetolactate synthase activity
AW19_3063	COG3085	chromosome segregation
AW19_3064	COG0583	DNA-binding transcription factor activity
AW19_3072	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AW19_3074	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AW19_3078	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AW19_3079	COG0678	peroxiredoxin activity
AW19_3079	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AW19_308	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW19_3080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AW19_3089	COG0165	Argininosuccinate lyase
AW19_309	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AW19_3090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AW19_3091	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AW19_3093	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AW19_3095	COG0527	aspartate kinase activity
AW19_3095	COG0460	homoserine dehydrogenase
AW19_3096	COG0626	cystathionine gamma-synthase activity
AW19_3097	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AW19_3098	COG0254	rRNA binding
AW19_3099	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AW19_310	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AW19_3100	COG1609	Transcriptional regulator
AW19_3101	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AW19_3102	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AW19_3103	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AW19_3104	COG1575	Belongs to the MenA family. Type 1 subfamily
AW19_3105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AW19_3106	COG3074	FtsZ-dependent cytokinesis
AW19_3107	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AW19_3108	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AW19_3109	COG1494	fructose-1,6-bisphosphatase
AW19_311	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AW19_3110	COG2814	Major facilitator Superfamily
AW19_3112	COG3152	Membrane
AW19_3116	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AW19_3118	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AW19_3119	COG3678	ATP-independent chaperone mediated protein folding
AW19_312	COG2233	PERMEase
AW19_3120	COG0745	RESPONSE REGULATOR receiver
AW19_3121	COG2205	protein histidine kinase activity
AW19_3122	COG2169	Transcriptional regulator
AW19_3122	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AW19_3123	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AW19_3124	COG1045	serine acetyltransferase
AW19_3125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AW19_3127	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AW19_3128	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AW19_3129	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AW19_313	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AW19_3130	COG4942	peptidase
AW19_3131	COG2861	carbohydrate metabolic process
AW19_3132	COG1063	alcohol dehydrogenase
AW19_3133	COG0156	8-amino-7-oxononanoate synthase activity
AW19_3134	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW19_3135	COG0859	PFAM glycosyl transferase family 9
AW19_3136	COG0859	PFAM glycosyl transferase family 9
AW19_3137	COG1519	Transferase
AW19_314	COG1393	Belongs to the ArsC family
AW19_3140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AW19_3141	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AW19_3142	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AW19_3143	COG2003	Belongs to the UPF0758 family
AW19_3144	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AW19_3145	COG0756	dUTP diphosphatase activity
AW19_3146	COG1309	transcriptional regulator
AW19_3148	COG4974	Belongs to the 'phage' integrase family
AW19_315	COG4783	chaperone-mediated protein folding
AW19_3158	COG5002	protein histidine kinase activity
AW19_3158	COG2176	DNA-directed DNA polymerase activity
AW19_316	COG0628	permease
AW19_3166	COG4695	Portal protein
AW19_317	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AW19_318	COG2716	regulation of RNA biosynthetic process
AW19_319	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AW19_3194	COG1561	YicC-like family, N-terminal region
AW19_320	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AW19_3200	COG5001	Diguanylate cyclase
AW19_3201	COG1024	Enoyl-CoA hydratase
AW19_3202	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW19_3203	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW19_3204	COG2860	membrane
AW19_3205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AW19_3207	COG1758	RNA polymerase activity
AW19_3208	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AW19_3209	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AW19_321	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AW19_3210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AW19_3211	COG0786	glutamate:sodium symporter activity
AW19_3212	COG2233	PERMEase
AW19_3213	COG2982	Protein involved in outer membrane biogenesis
AW19_3216	COG3423	Transcriptional regulator
AW19_3217	COG0456	acetyltransferase
AW19_3218	COG1490	D-aminoacyl-tRNA deacylase activity
AW19_3219	COG1295	ribonuclease BN
AW19_322	COG2321	neutral zinc metallopeptidase
AW19_3220	COG1011	Hydrolase
AW19_3222	COG0174	glutamine synthetase
AW19_3223	COG3852	Histidine kinase
AW19_3225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AW19_3226	COG3078	GTPase activator activity
AW19_3227	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AW19_3228	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW19_3228	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW19_3229	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AW19_323	COG2707	UPF0756 membrane protein
AW19_3230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AW19_3231	COG3084	Protein conserved in bacteria
AW19_3233	COG1763	Mo-molybdopterin cofactor biosynthetic process
AW19_324	COG1444	tRNA N-acetyltransferase activity
AW19_3240	COG2186	Transcriptional regulator
AW19_3241	COG1609	Transcriptional regulator
AW19_3242	COG0477	Major facilitator Superfamily
AW19_3243	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AW19_3244	COG1879	ABC-type sugar transport system periplasmic component
AW19_3245	COG1172	Belongs to the binding-protein-dependent transport system permease family
AW19_3247	COG1869	D-ribose catabolic process
AW19_3248	COG3158	transport of potassium into the cell
AW19_3249	COG0714	Associated with various cellular activities
AW19_325	COG0400	carboxylic ester hydrolase activity
AW19_3250	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AW19_3252	COG2502	aspartate--ammonia ligase
AW19_3253	COG1522	sequence-specific DNA binding
AW19_3254	COG0716	FMN binding
AW19_3255	COG0445	tRNA wobble uridine modification
AW19_3256	COG0357	Ribosomal RNA small subunit methyltransferase G
AW19_3257	COG3312	ion transport
AW19_3258	COG0356	it plays a direct role in the translocation of protons across the membrane
AW19_3260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AW19_3261	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AW19_3262	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AW19_3264	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AW19_3265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AW19_3266	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AW19_3267	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AW19_3268	COG0659	secondary active sulfate transmembrane transporter activity
AW19_3269	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AW19_327	COG1876	peptidase activity
AW19_3270	COG0573	inorganic phosphate transmembrane transporter activity
AW19_3271	COG0581	inorganic phosphate transmembrane transporter activity
AW19_3273	COG0704	Plays a role in the regulation of phosphate uptake
AW19_3275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW19_3276	COG0765	amino acid transport
AW19_3277	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AW19_3278	COG0765	amino acid transport
AW19_3279	COG2252	PERMEase
AW19_328	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AW19_3281	COG4566	intracellular signal transduction
AW19_3282	COG4191	Histidine kinase
AW19_3283	COG0431	NADPH-dependent FMN reductase
AW19_3284	COG0840	transmembrane signaling receptor activity
AW19_3285	COG2011	ABC-type metal ion transport system permease component
AW19_3288	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AW19_3289	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AW19_329	COG1393	Belongs to the ArsC family
AW19_3290	COG0706	membrane insertase activity
AW19_3292	COG0594	ribonuclease P activity
AW19_3293	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AW19_3294	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AW19_3295	COG0592	DNA-directed DNA polymerase activity
AW19_3296	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AW19_3297	COG0187	DNA topoisomerase II activity
AW19_3298	COG0561	phosphatase activity
AW19_3299	COG2423	ornithine cyclodeaminase activity
AW19_33	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AW19_3302	COG0823	Involved in the tonB-independent uptake of proteins
AW19_3303	COG5645	(Lipo)protein
AW19_3306	COG2985	domain, Protein
AW19_3306	COG0569	domain protein
AW19_3307	COG3977	Valine--pyruvate aminotransferase
AW19_3308	COG0366	Alpha amylase catalytic
AW19_3309	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AW19_3314	COG0456	acetyltransferase
AW19_3315	COG2818	Glycosylase
AW19_3318	COG0752	glycyl-tRNA synthetase alpha subunit
AW19_3319	COG0751	glycine-tRNA ligase activity
AW19_3321	COG2213	PTS system mannitol-specific
AW19_3321	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW19_3322	COG0246	Mannitol dehydrogenase
AW19_3324	COG3722	fumarate hydratase activity
AW19_3325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW19_3327	COG0840	transmembrane signaling receptor activity
AW19_3328	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AW19_3329	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AW19_333	COG1840	ABC-type Fe3 transport system, periplasmic component
AW19_3330	COG0243	molybdopterin cofactor binding
AW19_3330	COG3383	formate dehydrogenase (NAD+) activity
AW19_3331	COG3383	formate dehydrogenase (NAD+) activity
AW19_3331	COG0243	molybdopterin cofactor binding
AW19_3332	COG0437	4 iron, 4 sulfur cluster binding
AW19_3333	COG2864	formate dehydrogenase
AW19_3334	COG3058	Necessary for formate dehydrogenase activity
AW19_3335	COG1921	L-seryl-tRNASec selenium transferase activity
AW19_3336	COG3276	selenocysteine insertion sequence binding
AW19_3340	COG3550	peptidyl-serine autophosphorylation
AW19_3342	COG3274	enterobacterial common antigen metabolic process
AW19_3343	COG1335	isochorismatase
AW19_3344	COG3121	Chaperone
AW19_3345	COG1070	Carbohydrate kinase
AW19_3346	COG2115	Belongs to the xylose isomerase family
AW19_3347	COG4213	ABC transporter substrate-binding protein
AW19_3349	COG4214	carbohydrate transport
AW19_335	COG3842	ATPase activity
AW19_3350	COG1609	Transcriptional regulator
AW19_3350	COG2207	Transcriptional regulator
AW19_3352	COG2205	protein histidine kinase activity
AW19_3352	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW19_3357	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AW19_3358	COG2986	histidine ammonia-lyase
AW19_336	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AW19_3362	COG1764	response to oxidative stress
AW19_3363	COG2194	sulfuric ester hydrolase activity
AW19_3364	COG2197	response regulator
AW19_3365	COG3851	Histidine kinase
AW19_3366	COG2271	Major facilitator Superfamily
AW19_3370	COG2831	hemolysin activation secretion protein
AW19_3371	COG3210	domain, Protein
AW19_3372	COG0747	negative chemotaxis
AW19_3373	COG0601	transmembrane transport
AW19_3374	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AW19_3375	COG0444	Belongs to the ABC transporter superfamily
AW19_3376	COG4608	Belongs to the ABC transporter superfamily
AW19_3377	COG2194	sulfuric ester hydrolase activity
AW19_338	COG2197	response regulator
AW19_3381	COG1192	Involved in chromosome partitioning
AW19_3382	COG1215	transferase activity, transferring glycosyl groups
AW19_3383	COG1215	transferase activity, transferring glycosyl groups
AW19_3384	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AW19_3385	COG3118	belongs to the thioredoxin family
AW19_3385	COG0457	Tetratricopeptide repeat
AW19_3386	COG2199	diguanylate cyclase activity
AW19_3386	COG2200	EAL domain
AW19_3387	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AW19_3389	COG1301	dicarboxylic acid transport
AW19_3390	COG0612	Peptidase, M16
AW19_3391	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AW19_3392	COG1942	4-Oxalocrotonate Tautomerase
AW19_3393	COG2200	EAL domain
AW19_3394	COG2982	Protein involved in outer membrane biogenesis
AW19_3395	COG2134	cdp-diacylglycerol pyrophosphatase
AW19_3396	COG1295	ribonuclease BN
AW19_3398	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AW19_3399	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AW19_34	COG2137	regulation of response to DNA damage stimulus
AW19_340	COG3062	negative regulation of establishment of protein localization
AW19_3401	COG0742	ribosomal rna small subunit methyltransferase
AW19_3405	COG0589	response to stress
AW19_3407	COG0306	phosphate transporter
AW19_3408	COG2081	HI0933 family
AW19_341	COG0243	molybdopterin cofactor binding
AW19_3413	COG3121	Chaperone
AW19_3418	COG0488	(ABC) transporter
AW19_342	COG3043	anaerobic respiration
AW19_3421	COG3718	enzyme involved in inositol metabolism
AW19_3423	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AW19_3424	COG3962	Belongs to the TPP enzyme family
AW19_3425	COG0673	inositol 2-dehydrogenase activity
AW19_3426	COG1082	Xylose isomerase domain protein TIM barrel
AW19_3427	COG1082	Xylose isomerase domain protein TIM barrel
AW19_3428	COG1247	-acetyltransferase
AW19_3429	COG1741	Belongs to the pirin family
AW19_343	COG3005	denitrification pathway
AW19_3430	COG1609	Transcriptional regulator
AW19_3431	COG2610	gluconate transmembrane transporter activity
AW19_3432	COG3265	gluconokinase activity
AW19_3433	COG2095	MarC family integral membrane protein
AW19_3434	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AW19_3437	COG0463	Glycosyl transferase, family 2
AW19_3442	COG3275	phosphorelay sensor kinase activity
AW19_3443	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AW19_3444	COG1523	belongs to the glycosyl hydrolase 13 family
AW19_3446	COG0297	glycogen (starch) synthase activity
AW19_3447	COG0058	SHG alpha-glucan phosphorylase activity
AW19_3448	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AW19_3451	COG1349	DNA-binding transcription factor activity
AW19_3452	COG0705	Rhomboid family
AW19_3454	COG2909	trisaccharide binding
AW19_3455	COG0058	SHG alpha-glucan phosphorylase activity
AW19_3456	COG1640	4-alpha-glucanotransferase
AW19_3457	COG0316	Belongs to the HesB IscA family
AW19_3457	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AW19_3459	COG0596	Alpha beta hydrolase
AW19_346	COG0494	nUDIX hydrolase
AW19_3462	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AW19_3463	COG1918	ferrous iron import across plasma membrane
AW19_3464	COG2183	response to ionizing radiation
AW19_3469	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AW19_3470	COG0745	RESPONSE REGULATOR receiver
AW19_3472	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AW19_3474	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AW19_3475	COG1011	Hydrolase
AW19_3477	COG0494	nUDIX hydrolase
AW19_3478	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AW19_348	COG1671	Belongs to the UPF0178 family
AW19_3483	COG4796	Type ii and iii secretion system protein
AW19_3484	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AW19_3488	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AW19_349	COG0408	coproporphyrinogen oxidase activity
AW19_3490	COG0180	Tryptophanyl-tRNA synthetase
AW19_3491	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AW19_3491	COG1648	precorrin-2 dehydrogenase activity
AW19_3493	COG2146	nitrite reductase [NAD(P)H] activity
AW19_3494	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AW19_3495	COG0402	S-adenosylhomocysteine deaminase activity
AW19_3496	COG0738	Major facilitator superfamily
AW19_3497	COG1609	Transcriptional regulator
AW19_3498	COG1486	melibiose metabolic process
AW19_3499	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AW19_35	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AW19_350	COG0456	acetyltransferase
AW19_3500	COG0433	COG0433 Predicted ATPase
AW19_3504	COG1289	transmembrane transporter activity
AW19_3506	COG1765	OsmC-like protein
AW19_3507	COG3954	Phosphoribulokinase
AW19_3508	COG3089	Belongs to the UPF0270 family
AW19_3509	COG0429	hydrolase of the alpha beta-hydrolase fold
AW19_351	COG3111	PFAM Bacterial OB fold (BOF) protein
AW19_3512	COG4521	taurine ABC transporter
AW19_3514	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AW19_3516	COG2175	clavaminate synthase activity
AW19_3518	COG0488	(ABC) transporter
AW19_3519	COG2249	NAD(P)H dehydrogenase (quinone) activity
AW19_3521	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AW19_3522	COG1047	Peptidyl-prolyl cis-trans
AW19_3523	COG2900	Belongs to the SlyX family
AW19_3524	COG0545	Peptidyl-prolyl cis-trans isomerase
AW19_3525	COG2964	Protein conserved in bacteria
AW19_3526	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AW19_3527	COG2923	Belongs to the DsrF TusC family
AW19_3528	COG2168	tRNA wobble position uridine thiolation
AW19_3529	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AW19_353	COG2837	iron assimilation
AW19_3530	COG0049	tRNA binding
AW19_3532	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AW19_3535	COG0051	transcription antitermination factor activity, RNA binding
AW19_3536	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AW19_3538	COG0089	rRNA binding
AW19_3539	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AW19_354	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AW19_3540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AW19_3541	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AW19_3542	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AW19_3543	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AW19_3544	COG0255	Belongs to the universal ribosomal protein uL29 family
AW19_3545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AW19_3546	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AW19_3547	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AW19_3549	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AW19_3551	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AW19_3552	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AW19_3554	COG1841	ribosomal large subunit assembly
AW19_3555	COG0200	Binds to the 23S rRNA
AW19_3556	COG0201	protein transport
AW19_3557	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AW19_3558	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AW19_3559	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AW19_3560	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AW19_3561	COG0202	RNA polymerase activity
AW19_3562	COG0203	ribosomal protein L17
AW19_3564	COG0789	Transcriptional regulator
AW19_3565	COG3036	rescue of stalled ribosome
AW19_3566	COG1970	mechanosensitive ion channel activity
AW19_3567	COG0569	domain protein
AW19_3568	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AW19_3568	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AW19_3569	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AW19_357	COG2731	YhcH YjgK YiaL family protein
AW19_3570	COG0242	peptide deformylase activity
AW19_3571	COG0758	DNA mediated transformation
AW19_3573	COG0551	DNA topoisomerase type I activity
AW19_3574	COG0009	L-threonylcarbamoyladenylate synthase
AW19_3575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AW19_3576	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AW19_358	COG1737	Transcriptional regulator
AW19_3583	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AW19_3584	COG3162	membrane
AW19_3585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AW19_3587	COG1301	dicarboxylic acid transport
AW19_36	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AW19_360	COG4150	thiosulfate binding
AW19_361	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AW19_362	COG4208	sulfate ABC transporter
AW19_3620	COG2391	methyltransferase activity
AW19_3621	COG0425	Belongs to the sulfur carrier protein TusA family
AW19_3622	COG3264	Mechanosensitive ion channel
AW19_3622	COG1511	domain protein
AW19_3623	COG4774	siderophore transport
AW19_3625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW19_3626	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AW19_3627	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW19_3628	COG4558	Periplasmic binding protein
AW19_3629	COG3720	iron ion transport
AW19_3634	COG0305	Participates in initiation and elongation during chromosome replication
AW19_365	COG0745	RESPONSE REGULATOR receiver
AW19_366	COG2205	protein histidine kinase activity
AW19_367	COG2190	(PTS) system
AW19_3671	COG3547	Transposase (IS116 IS110 IS902 family)
AW19_3675	COG2826	transposase and inactivated derivatives, IS30 family
AW19_3676	COG2826	transposase and inactivated derivatives, IS30 family
AW19_368	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AW19_3687	COG3657	addiction module killer protein
AW19_369	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW19_370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AW19_3700	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AW19_3701	COG0210	DNA helicase
AW19_3703	COG2826	transposase and inactivated derivatives, IS30 family
AW19_3708	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AW19_3710	COG1309	transcriptional regulator
AW19_3712	COG2084	Dehydrogenase
AW19_3714	COG1929	Belongs to the glycerate kinase type-1 family
AW19_3715	COG3835	regulator
AW19_3716	COG2721	sulfolactate sulfo-lyase activity
AW19_3717	COG2271	Major facilitator Superfamily
AW19_3719	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AW19_3719	COG0493	'glutamate synthase
AW19_3720	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AW19_3721	COG3383	formate dehydrogenase (NAD+) activity
AW19_3722	COG4232	protein-disulfide reductase activity
AW19_3724	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AW19_3727	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AW19_3728	COG0459	protein refolding
AW19_373	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AW19_3731	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AW19_3733	COG2076	Multidrug Resistance protein
AW19_3735	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AW19_3736	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AW19_3737	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AW19_3738	COG1053	succinate dehydrogenase
AW19_3739	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AW19_374	COG3530	Putative quorum-sensing-regulated virulence factor
AW19_3740	COG3264	Mechanosensitive ion channel
AW19_3740	COG1511	domain protein
AW19_3741	COG0688	phosphatidylethanolamine metabolic process
AW19_3742	COG1162	GTPase activity
AW19_3743	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AW19_3747	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AW19_3748	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AW19_3748	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AW19_3749	COG0802	atpase or kinase
AW19_3750	COG0860	N-Acetylmuramoyl-L-alanine amidase
AW19_3751	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AW19_3752	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AW19_3754	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AW19_3755	COG0330	HflC and HflK could
AW19_3756	COG0330	HflC and HflK could
AW19_3757	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AW19_3758	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AW19_3759	COG1959	2 iron, 2 sulfur cluster binding
AW19_3760	COG0557	exoribonuclease II activity
AW19_3761	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AW19_3762	COG1960	acyl-CoA dehydrogenase activity
AW19_3763	COG3650	response to hydrogen peroxide
AW19_3764	COG1073	alpha beta
AW19_3766	COG0360	Binds together with S18 to 16S ribosomal RNA
AW19_3767	COG2965	DNA replication, synthesis of RNA primer
AW19_3768	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AW19_3769	COG0359	binds to the 23S rRNA
AW19_3771	COG3061	Opacity-associated protein A
AW19_3772	COG0545	Peptidyl-prolyl cis-trans isomerase
AW19_3774	COG0737	Belongs to the 5'-nucleotidase family
AW19_3775	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AW19_3776	COG1218	3'(2'),5'-bisphosphate nucleotidase
AW19_3778	COG1253	flavin adenine dinucleotide binding
AW19_3779	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AW19_3780	COG0729	surface antigen
AW19_3781	COG2911	Protein conserved in bacteria
AW19_3782	COG2105	PFAM AIG2 family protein
AW19_3783	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AW19_3784	COG0840	transmembrane signaling receptor activity
AW19_3785	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AW19_3786	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AW19_3789	COG1438	arginine binding
AW19_3790	COG0039	L-malate dehydrogenase activity
AW19_3791	COG3423	Transcriptional regulator
AW19_3793	COG0142	geranyltranstransferase activity
AW19_3796	COG0697	spore germination
AW19_3797	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AW19_3798	COG0642	Histidine kinase
AW19_3799	COG0745	RESPONSE REGULATOR receiver
AW19_380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AW19_3800	COG2027	D-alanyl-D-alanine carboxypeptidase
AW19_3801	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AW19_3802	COG1534	Rna-binding protein
AW19_3803	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AW19_3804	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AW19_3805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AW19_3807	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AW19_3810	COG0779	Required for maturation of 30S ribosomal subunits
AW19_3811	COG0195	Participates in both transcription termination and antitermination
AW19_3812	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AW19_3813	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AW19_3814	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AW19_3816	COG1185	polyribonucleotide nucleotidyltransferase activity
AW19_3818	COG0513	Belongs to the DEAD box helicase family
AW19_3819	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AW19_3823	COG2827	Endonuclease containing a URI domain
AW19_3824	COG3153	acetyltransferase
AW19_3825	COG0531	amino acid
AW19_3826	COG1982	Orn Lys Arg decarboxylase major
AW19_3829	COG1653	transport
AW19_3831	COG0395	ABC-type sugar transport system, permease component
AW19_3832	COG3842	ATPase activity
AW19_3834	COG3787	Belongs to the UPF0306 family
AW19_3835	COG0702	epimerase
AW19_3836	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AW19_3837	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AW19_3838	COG3454	Phosphonate metabolism
AW19_3839	COG4778	phosphonate C-P lyase system protein PhnL
AW19_384	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW19_3840	COG4107	phosphonate C-P lyase system protein PhnK
AW19_3841	COG3627	carbon phosphorus lyase activity
AW19_3842	COG3626	phosphonate metabolism
AW19_3843	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AW19_3844	COG3624	Phosphonate C-P lyase system protein PhnG
AW19_3845	COG2188	Transcriptional regulator
AW19_3848	COG4608	Belongs to the ABC transporter superfamily
AW19_3849	COG0444	Belongs to the ABC transporter superfamily
AW19_3851	COG0601	transmembrane transport
AW19_3853	COG2731	YhcH YjgK YiaL family protein
AW19_3855	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AW19_3858	COG2927	DNA polymerase III (CHI subunit)
AW19_3859	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AW19_3860	COG0795	lipopolysaccharide-transporting ATPase activity
AW19_3861	COG0795	lipopolysaccharide-transporting ATPase activity
AW19_3865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AW19_3870	COG3210	domain, Protein
AW19_3873	COG3210	domain, Protein
AW19_3874	COG2831	hemolysin activation secretion protein
AW19_388	COG0667	Aldo Keto reductase
AW19_3882	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AW19_3883	COG1830	Aldolase
AW19_3884	COG1879	ABC-type sugar transport system periplasmic component
AW19_3885	COG1172	Belongs to the binding-protein-dependent transport system permease family
AW19_3886	COG1172	Belongs to the binding-protein-dependent transport system permease family
AW19_3887	COG1129	ABC transporter
AW19_3888	COG2390	Transcriptional regulator
AW19_3889	COG1070	Carbohydrate kinase
AW19_389	COG0583	DNA-binding transcription factor activity
AW19_3890	COG0859	PFAM glycosyl transferase family 9
AW19_3893	COG2235	arginine
AW19_3894	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AW19_3895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AW19_3897	COG2376	Dihydroxyacetone kinase
AW19_3898	COG1461	Dihydroxyacetone kinase
AW19_3899	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW19_3899	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AW19_3899	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AW19_3901	COG2192	nodulation
AW19_3907	COG3706	GGDEF domain
AW19_391	COG0837	glucose binding
AW19_3911	COG0583	DNA-binding transcription factor activity
AW19_3912	COG0667	Aldo Keto reductase
AW19_3913	COG2813	Specifically methylates the guanine in position
AW19_3914	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
AW19_3915	COG0456	acetyltransferase
AW19_3916	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AW19_3917	COG2823	Periplasmic or secreted lipoprotein
AW19_3919	COG4667	esterase of the alpha-beta hydrolase superfamily
AW19_392	COG2223	nitrite transmembrane transporter activity
AW19_3920	COG0084	hydrolase, TatD family'
AW19_3921	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW19_3922	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AW19_3923	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AW19_3924	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AW19_3926	COG3726	membrane protein affecting hemolysin expression
AW19_3927	COG0560	Phosphoserine phosphatase
AW19_393	COG3279	Response regulator of the LytR AlgR family
AW19_3931	COG0604	alcohol dehydrogenase
AW19_3933	COG0488	(ABC) transporter
AW19_3934	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AW19_3935	COG0741	lytic transglycosylase activity
AW19_3936	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AW19_3937	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AW19_3938	COG2207	Transcriptional regulator
AW19_3938	COG3708	Transcriptional regulator
AW19_394	COG3275	phosphorelay sensor kinase activity
AW19_3940	COG3045	CreA protein
AW19_3941	COG0745	RESPONSE REGULATOR receiver
AW19_3943	COG0083	homoserine kinase activity
AW19_3945	COG3022	response to hydroperoxide
AW19_3946	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AW19_3947	COG0521	Mo-molybdopterin cofactor biosynthetic process
AW19_3948	COG0477	Major facilitator Superfamily
AW19_3951	COG1584	GPR1 FUN34 yaaH family protein
AW19_3953	COG0484	heat shock protein binding
AW19_3954	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AW19_3955	COG0583	DNA-binding transcription factor activity
AW19_3957	COG0196	riboflavin kinase activity
AW19_3958	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AW19_3959	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AW19_3960	COG1047	Peptidyl-prolyl cis-trans
AW19_3961	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AW19_3962	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AW19_3963	COG0505	Belongs to the CarA family
AW19_3964	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AW19_3965	COG1280	lysine exporter protein (LysE YggA)
AW19_3966	COG2966	Psort location CytoplasmicMembrane, score
AW19_3968	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AW19_397	COG0436	Aminotransferase
AW19_3971	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AW19_3972	COG2967	ApaG domain
AW19_3974	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AW19_3975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AW19_3976	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AW19_3978	COG0564	pseudouridine synthase activity
AW19_3979	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AW19_398	COG3038	cytochrome b561
AW19_3980	COG0417	DNA replication proofreading
AW19_3981	COG0586	Pfam SNARE associated Golgi protein
AW19_3983	COG1178	ABC-type Fe3 transport system permease component
AW19_3984	COG4143	(ABC) transporter
AW19_3985	COG4533	DNA binding
AW19_3986	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AW19_3988	COG2814	Major facilitator Superfamily
AW19_3989	COG3033	Beta-eliminating lyase
AW19_3992	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AW19_3993	COG0473	3-isopropylmalate dehydrogenase activity
AW19_3994	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AW19_3997	COG1022	Amp-dependent synthetase and ligase
AW19_3998	COG0028	Belongs to the TPP enzyme family
AW19_4	COG1028	Short-chain dehydrogenase reductase Sdr
AW19_4000	COG1609	Transcriptional regulator
AW19_4002	COG2001	Belongs to the MraZ family
AW19_4003	COG0275	rRNA processing
AW19_4004	COG3116	cell division
AW19_4005	COG0768	penicillin binding
AW19_4006	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AW19_4007	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AW19_4010	COG0772	Belongs to the SEDS family
AW19_4011	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AW19_4012	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AW19_4014	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AW19_4015	COG0849	cell division
AW19_4016	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AW19_4020	COG0653	protein targeting
AW19_4021	COG0494	nUDIX hydrolase
AW19_4022	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AW19_4024	COG0237	dephospho-CoA kinase activity
AW19_4025	COG0516	GMP reductase activity
AW19_4026	COG1459	type II secretion system
AW19_4027	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AW19_4028	COG4969	Belongs to the N-Me-Phe pilin family
AW19_4031	COG3725	Membrane protein required for beta-lactamase induction
AW19_4032	COG1113	amino acid transport
AW19_4033	COG2186	Transcriptional regulator
AW19_4034	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AW19_4035	COG0508	dehydrogenase complex catalyzes the overall conversion of
AW19_4036	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AW19_4038	COG4977	sequence-specific DNA binding
AW19_404	COG3381	protein complex oligomerization
AW19_4040	COG1049	propionate catabolic process, 2-methylcitrate cycle
AW19_4042	COG0697	spore germination
AW19_4043	COG3112	Uncharacterised protein family (UPF0231)
AW19_4044	COG3210	domain, Protein
AW19_4046	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AW19_4047	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AW19_4049	COG2132	Multicopper oxidase
AW19_405	COG3302	dmso reductase anchor subunit
AW19_4051	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AW19_4052	COG0288	reversible hydration of carbon dioxide
AW19_4053	COG1131	(ABC) transporter
AW19_4054	COG0842	Transport permease protein
AW19_4055	COG0726	polysaccharide deacetylase
AW19_4056	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AW19_4057	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AW19_4058	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AW19_4059	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AW19_406	COG0437	4 iron, 4 sulfur cluster binding
AW19_4060	COG0617	tRNA 3'-terminal CCA addition
AW19_4062	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AW19_4063	COG1489	DNA binding
AW19_4064	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AW19_4065	COG1643	Atp-dependent helicase
AW19_4066	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AW19_4067	COG1120	ATPase activity
AW19_4068	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW19_4069	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW19_407	COG0243	molybdopterin cofactor binding
AW19_4070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AW19_4072	COG0316	Belongs to the HesB IscA family
AW19_4074	COG2860	membrane
AW19_4076	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AW19_4077	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AW19_4078	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AW19_4079	COG2205	protein histidine kinase activity
AW19_4079	COG3437	response regulator, receiver
AW19_4079	COG3850	Histidine kinase
AW19_4079	COG4999	Histidine kinase
AW19_4080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AW19_4081	COG3956	TIGRFAM MazG family protein
AW19_4082	COG0504	CTP synthase activity
AW19_4083	COG0148	phosphopyruvate hydratase activity
AW19_4089	COG0602	queuosine metabolic process
AW19_409	COG1280	lysine exporter protein (LysE YggA)
AW19_4090	COG0720	synthase
AW19_4091	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AW19_4092	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AW19_4093	COG0175	sulfate reduction
AW19_4094	COG2234	aminopeptidase activity
AW19_4095	COG1648	precorrin-2 dehydrogenase activity
AW19_4095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AW19_4096	COG0175	sulfate reduction
AW19_4097	COG2895	sulfate adenylyltransferase (ATP) activity
AW19_4098	COG0529	Catalyzes the synthesis of activated sulfate
AW19_41	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AW19_4101	COG0765	amino acid transport
AW19_4103	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AW19_4105	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AW19_4106	COG0585	pseudouridine synthase activity
AW19_4107	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AW19_4108	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AW19_4109	COG1388	LysM domain
AW19_4109	COG4942	peptidase
AW19_4110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AW19_4111	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AW19_4116	COG3188	usher protein
AW19_4117	COG3121	Chaperone
AW19_4119	COG3539	Fimbrial protein
AW19_4120	COG3539	Fimbrial protein
AW19_4126	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AW19_4127	COG1136	(ABC) transporter
AW19_4127	COG0577	efflux transmembrane transporter activity
AW19_4128	COG1538	Outer membrane efflux protein
AW19_4129	COG3451	type IV secretory pathway VirB4
AW19_413	COG2951	lytic endotransglycosylase activity
AW19_414	COG0531	amino acid
AW19_4141	COG0484	heat shock protein binding
AW19_4145	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AW19_4146	COG3657	addiction module killer protein
AW19_4156	COG1192	Involved in chromosome partitioning
AW19_4176	COG2916	Histone family protein nucleoid-structuring protein H-NS
AW19_4177	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AW19_418	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AW19_4182	COG0741	lytic transglycosylase activity
AW19_419	COG1127	ABC transporter
AW19_4194	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AW19_4197	COG3736	Type IV secretory pathway, component VirB8
AW19_42	COG1238	metal cluster binding
AW19_422	COG3038	cytochrome b561
AW19_423	COG2353	YceI-like domain
AW19_424	COG1609	Transcriptional regulator
AW19_425	COG1263	PTS System
AW19_425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW19_426	COG2723	6-phospho-beta-galactosidase activity
AW19_43	COG2918	glutathione biosynthetic process
AW19_430	COG2824	Alkylphosphonate utilization operon protein PhnA
AW19_431	COG2850	peptidyl-arginine hydroxylation
AW19_432	COG5265	(ABC) transporter
AW19_437	COG2197	response regulator
AW19_438	COG1278	Cold shock
AW19_439	COG1278	Cold shock
AW19_44	COG1854	S-ribosylhomocysteine lyase activity
AW19_440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AW19_441	COG3706	GGDEF domain
AW19_442	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AW19_443	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AW19_444	COG0321	lipoyl(octanoyl) transferase activity
AW19_445	COG2921	Belongs to the UPF0250 family
AW19_446	COG1686	Belongs to the peptidase S11 family
AW19_447	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AW19_448	COG0772	Belongs to the SEDS family
AW19_449	COG0768	penicillin binding
AW19_45	COG4536	flavin adenine dinucleotide binding
AW19_451	COG0799	negative regulation of ribosome biogenesis
AW19_452	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AW19_453	COG1466	dna polymerase III delta subunit
AW19_454	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AW19_456	COG2888	peptidyl-tyrosine sulfation
AW19_458	COG1126	abc transporter atp-binding protein
AW19_459	COG0765	amino acid transport
AW19_46	COG4137	Cytochrome C assembly protein
AW19_460	COG0765	amino acid transport
AW19_463	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AW19_464	COG4535	Mg2 and Co2 transporter CorC
AW19_465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AW19_466	COG1702	phosphate starvation-inducible protein PhoH
AW19_467	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AW19_468	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AW19_47	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AW19_474	COG0367	asparagine synthase
AW19_475	COG0647	UMP catabolic process
AW19_476	COG1846	Transcriptional regulator
AW19_476	COG1940	carbohydrate kinase activity
AW19_477	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AW19_478	COG0363	glucosamine-6-phosphate deaminase activity
AW19_479	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW19_479	COG1263	PTS System
AW19_479	COG2190	(PTS) system
AW19_480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AW19_484	COG0735	belongs to the Fur family
AW19_486	COG0840	transmembrane signaling receptor activity
AW19_489	COG0596	Alpha beta hydrolase
AW19_49	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AW19_490	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AW19_491	COG0033	Phosphoglucomutase
AW19_494	COG0745	RESPONSE REGULATOR receiver
AW19_495	COG2205	protein histidine kinase activity
AW19_496	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AW19_497	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AW19_498	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AW19_50	COG0336	Belongs to the RNA methyltransferase TrmD family
AW19_500	COG3272	Protein of unknown function (DUF1722)
AW19_502	COG5212	phosphodiesterase
AW19_503	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AW19_504	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AW19_505	COG1984	allophanate hydrolase subunit 2
AW19_506	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AW19_509	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AW19_51	COG0335	large ribosomal subunit rRNA binding
AW19_511	COG2009	succinate dehydrogenase
AW19_512	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AW19_513	COG1053	succinate dehydrogenase
AW19_515	COG0567	Dehydrogenase, E1 component
AW19_516	COG0508	dehydrogenase complex catalyzes the overall conversion of
AW19_518	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AW19_519	COG0737	Belongs to the 5'-nucleotidase family
AW19_52	COG3137	Salt-induced outer membrane protein
AW19_520	COG1271	oxidase subunit
AW19_521	COG1294	oxidase, subunit
AW19_522	COG4890	Cyd operon protein YbgT
AW19_523	COG3790	cyd operon protein YbgE
AW19_524	COG0824	Thioesterase
AW19_525	COG0811	peptide transport
AW19_526	COG0848	biopolymer transport protein
AW19_527	COG3064	Membrane
AW19_527	COG3064	Membrane
AW19_528	COG0823	Involved in the tonB-independent uptake of proteins
AW19_529	COG2885	chlorophyll binding
AW19_53	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AW19_530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AW19_535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AW19_537	COG1230	cation diffusion facilitator family transporter
AW19_538	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AW19_539	COG0588	phosphoglycerate mutase activity
AW19_54	COG3279	Response regulator of the LytR AlgR family
AW19_541	COG2017	converts alpha-aldose to the beta-anomer
AW19_542	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AW19_544	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AW19_546	COG1119	ATPase activity
AW19_547	COG3585	molybdate ion transport
AW19_547	COG2005	Transcriptional regulator
AW19_549	COG0725	ABC transporter, periplasmic molybdate-binding protein
AW19_55	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AW19_550	COG4149	molybdate abc transporter
AW19_552	COG0561	phosphatase activity
AW19_553	COG2706	6-phosphogluconolactonase activity
AW19_555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AW19_556	COG0156	8-amino-7-oxononanoate synthase activity
AW19_557	COG2226	methyltransferase
AW19_558	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AW19_559	COG0410	ABC transporter
AW19_56	COG1605	Chorismate mutase
AW19_56	COG0287	Prephenate dehydrogenase
AW19_560	COG0556	nucleotide-excision repair
AW19_561	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AW19_562	COG4628	conserved protein (DUF2132)
AW19_563	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AW19_564	COG0315	cyclic pyranopterin monophosphate synthase activity
AW19_565	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AW19_566	COG0314	molybdopterin synthase activity
AW19_567	COG0670	Belongs to the BI1 family
AW19_568	COG0842	Transport permease protein
AW19_569	COG0842	Transport permease protein
AW19_57	COG0077	Prephenate dehydratase
AW19_57	COG1605	Chorismate mutase
AW19_570	COG1131	(ABC) transporter
AW19_571	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AW19_572	COG1309	transcriptional regulator
AW19_573	COG0513	Belongs to the DEAD box helicase family
AW19_574	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AW19_576	COG2239	Acts as a magnesium transporter
AW19_578	COG1686	Belongs to the peptidase S11 family
AW19_579	COG0277	FAD linked oxidase domain protein
AW19_58	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AW19_581	COG1403	HNH endonuclease
AW19_583	COG2261	transglycosylase associated protein
AW19_585	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AW19_588	COG4807	Protein conserved in bacteria
AW19_589	COG2897	thiosulfate sulfurtransferase activity
AW19_59	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AW19_592	COG1732	Glycine betaine
AW19_593	COG1174	glycine betaine transport
AW19_594	COG1125	glycine betaine transport
AW19_595	COG1174	glycine betaine transport
AW19_598	COG0697	spore germination
AW19_6	COG1858	cytochrome C peroxidase
AW19_60	COG0564	pseudouridine synthase activity
AW19_601	COG1199	ATP-dependent helicase activity
AW19_602	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AW19_603	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AW19_606	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AW19_608	COG1126	abc transporter atp-binding protein
AW19_609	COG0765	amino acid transport
AW19_610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW19_611	COG0783	Belongs to the Dps family
AW19_612	COG4106	trans-aconitate 2-methyltransferase activity
AW19_615	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AW19_618	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AW19_62	COG0542	response to heat
AW19_620	COG0488	(ABC) transporter
AW19_621	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AW19_622	COG0303	'Molybdopterin
AW19_624	COG0477	Major facilitator Superfamily
AW19_626	COG1136	(ABC) transporter
AW19_626	COG0577	efflux transmembrane transporter activity
AW19_632	COG0583	DNA-binding transcription factor activity
AW19_633	COG0477	Major facilitator Superfamily
AW19_634	COG0302	gtp cyclohydrolase
AW19_635	COG2311	Membrane
AW19_640	COG2116	formate transmembrane transporter activity
AW19_641	COG3604	Transcriptional regulator
AW19_642	COG3383	formate dehydrogenase (NAD+) activity
AW19_643	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AW19_644	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AW19_646	COG3260	NADH ubiquinone oxidoreductase 20
AW19_647	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AW19_648	COG3261	NADH dehydrogenase
AW19_648	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AW19_649	COG0651	ATP synthesis coupled electron transport
AW19_650	COG4237	Hydrogenase 4 membrane
AW19_651	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AW19_652	COG0650	Formate hydrogenlyase subunit 4
AW19_653	COG0651	ATP synthesis coupled electron transport
AW19_654	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AW19_655	COG0375	protein maturation
AW19_656	COG0298	carbon dioxide binding
AW19_657	COG2949	membrane
AW19_658	COG0281	malic enzyme
AW19_661	COG1346	cytolysis
AW19_662	COG1380	Effector of murein hydrolase LrgA
AW19_663	COG2814	Major facilitator Superfamily
AW19_667	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AW19_667	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AW19_668	COG0489	protein tyrosine kinase activity
AW19_669	COG0572	uridine kinase
AW19_670	COG0717	Belongs to the dCTP deaminase family
AW19_671	COG2982	Protein involved in outer membrane biogenesis
AW19_672	COG3069	C4-dicarboxylate transmembrane transporter activity
AW19_673	COG1253	flavin adenine dinucleotide binding
AW19_674	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AW19_675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AW19_676	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AW19_677	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AW19_677	COG0140	phosphoribosyl-ATP diphosphatase activity
AW19_678	COG0107	imidazoleglycerol-phosphate synthase activity
AW19_679	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AW19_680	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AW19_681	COG0131	Imidazoleglycerol-phosphate dehydratase
AW19_681	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AW19_682	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AW19_684	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AW19_685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW19_686	COG1172	Belongs to the binding-protein-dependent transport system permease family
AW19_687	COG1129	ABC transporter
AW19_688	COG0371	Dehydrogenase
AW19_69	COG0656	L-ascorbic acid biosynthetic process
AW19_690	COG0531	amino acid
AW19_691	COG2925	Exonuclease
AW19_692	COG3320	Male sterility
AW19_692	COG1022	Amp-dependent synthetase and ligase
AW19_693	COG1289	transmembrane transporter activity
AW19_696	COG1172	Belongs to the binding-protein-dependent transport system permease family
AW19_698	COG1879	ABC-type sugar transport system periplasmic component
AW19_70	COG0583	DNA-binding transcription factor activity
AW19_700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AW19_701	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AW19_701	COG1648	precorrin-2 dehydrogenase activity
AW19_702	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AW19_704	COG4810	utilization protein
AW19_706	COG4656	Part of a membrane complex involved in electron transport
AW19_708	COG1012	belongs to the aldehyde dehydrogenase family
AW19_71	COG2814	Major facilitator Superfamily
AW19_714	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AW19_721	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AW19_726	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AW19_728	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AW19_729	COG2241	protein methyltransferase activity
AW19_73	COG3021	interspecies interaction between organisms
AW19_731	COG2875	Belongs to the precorrin methyltransferase family
AW19_74	COG1388	LysM domain
AW19_74	COG0741	lytic transglycosylase activity
AW19_741	COG1492	cobalamin metabolic process
AW19_744	COG0406	alpha-ribazole phosphatase activity
AW19_745	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AW19_746	COG0583	DNA-binding transcription factor activity
AW19_748	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AW19_749	COG2211	Major facilitator Superfamily
AW19_75	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW19_750	COG0137	argininosuccinate synthase activity
AW19_751	COG0534	Mate efflux family protein
AW19_753	COG0352	thiamine-phosphate diphosphorylase activity
AW19_754	COG0561	phosphatase activity
AW19_755	COG1349	DNA-binding transcription factor activity
AW19_756	COG2814	Major facilitator Superfamily
AW19_758	COG0583	DNA-binding transcription factor activity
AW19_759	COG0784	Response regulator, receiver
AW19_759	COG0835	chemotaxis
AW19_76	COG2226	methyltransferase
AW19_761	COG3121	Chaperone
AW19_764	COG3121	Chaperone
AW19_766	COG2205	protein histidine kinase activity
AW19_766	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW19_769	COG0251	oxidation-reduction process
AW19_77	COG0328	RNA-DNA hybrid ribonuclease activity
AW19_771	COG2977	Belongs to the P-Pant transferase superfamily
AW19_774	COG3433	isochorismatase activity
AW19_774	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AW19_774	COG2226	methyltransferase
AW19_779	COG1021	2,3-dihydroxybenzoate-AMP ligase
AW19_78	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AW19_780	COG1169	isochorismate synthase
AW19_782	COG4771	TonB-dependent receptor
AW19_784	COG0601	transmembrane transport
AW19_785	COG4171	peptide transport system, permease
AW19_791	COG3842	ATPase activity
AW19_793	COG1840	ABC-type Fe3 transport system, periplasmic component
AW19_794	COG2271	Major facilitator Superfamily
AW19_797	COG4565	transcriptional regulatory protein
AW19_798	COG3290	protein histidine kinase activity
AW19_799	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AW19_8	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AW19_80	COG2113	Glycine betaine
AW19_800	COG3052	prosthetic group binding
AW19_801	COG2301	Belongs to the HpcH HpaI aldolase family
AW19_802	COG3051	citrate lyase alpha subunit
AW19_803	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AW19_803	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
AW19_805	COG0471	metal ion transport
AW19_808	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AW19_81	COG4176	ABC-type proline glycine betaine transport system permease component
AW19_816	COG3228	Belongs to the MtfA family
AW19_818	COG3547	Transposase (IS116 IS110 IS902 family)
AW19_822	COG3121	Chaperone
AW19_823	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AW19_824	COG4589	Belongs to the CDS family
AW19_826	COG2267	carboxylic ester hydrolase activity
AW19_827	COG0671	phosphoesterase, PA-phosphatase related
AW19_827	COG2453	phosphatase
AW19_83	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AW19_830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AW19_836	COG0604	alcohol dehydrogenase
AW19_836	COG1028	Short-chain dehydrogenase reductase Sdr
AW19_836	COG3321	synthase
AW19_837	COG3250	beta-galactosidase activity
AW19_838	COG1609	Transcriptional regulator
AW19_839	COG1278	Cold shock
AW19_841	COG0840	transmembrane signaling receptor activity
AW19_842	COG1285	pathogenesis
AW19_844	COG2130	NADP-dependent
AW19_845	COG0589	response to stress
AW19_849	COG1360	Flagellar Motor Protein
AW19_85	COG1780	Probably involved in ribonucleotide reductase function
AW19_850	COG0643	Histidine kinase
AW19_850	COG2198	Histidine kinase
AW19_851	COG0835	chemotaxis
AW19_852	COG0840	transmembrane signaling receptor activity
AW19_853	COG0840	transmembrane signaling receptor activity
AW19_854	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AW19_856	COG0745	RESPONSE REGULATOR receiver
AW19_857	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AW19_859	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AW19_86	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AW19_860	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AW19_863	COG3418	PFAM FlgN family protein
AW19_864	COG2747	anti-sigma28 factor FlgM
AW19_866	COG1815	bacterial-type flagellum-dependent cell motility
AW19_867	COG1558	bacterial-type flagellum-dependent cell motility
AW19_868	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AW19_869	COG1749	Flagellar hook protein flgE
AW19_87	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AW19_871	COG4786	Flagellar basal body rod
AW19_875	COG1256	bacterial-type flagellum assembly
AW19_876	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AW19_883	COG1580	Controls the rotational direction of flagella during chemotaxis
AW19_885	COG2882	bacterial-type flagellum organization
AW19_887	COG1317	bacterial-type flagellum organization
AW19_888	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AW19_89	COG4575	ribosome binding
AW19_890	COG1677	Flagellar hook-basal body complex protein FliE
AW19_892	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AW19_893	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AW19_899	COG1191	sigma factor activity
AW19_9	COG0640	Transcriptional regulator
AW19_901	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AW19_908	COG0506	proline dehydrogenase activity
AW19_908	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AW19_908	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AW19_913	COG0655	NAD(P)H dehydrogenase (quinone) activity
AW19_914	COG0477	Major facilitator Superfamily
AW19_916	COG3423	Transcriptional regulator
AW19_918	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
AW19_919	COG1113	amino acid transport
AW19_921	COG0582	viral genome integration into host DNA
AW19_923	COG0582	viral genome integration into host DNA
AW19_930	COG0366	Alpha amylase catalytic
AW19_933	COG2197	response regulator
AW19_934	COG0322	excinuclease ABC activity
AW19_935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AW19_943	COG3493	citrate carrier protein
AW19_944	COG4565	transcriptional regulatory protein
AW19_945	COG3290	protein histidine kinase activity
AW19_946	COG1349	DNA-binding transcription factor activity
AW19_947	COG3395	kinase activity
AW19_948	COG0235	Class ii aldolase
AW19_949	COG3622	Belongs to the hyi family
AW19_950	COG2066	Belongs to the glutaminase family
AW19_954	COG0672	)-iron permease
AW19_957	COG0577	efflux transmembrane transporter activity
AW19_957	COG1136	(ABC) transporter
AW19_959	COG1136	(ABC) transporter
AW19_959	COG0577	efflux transmembrane transporter activity
AW19_96	COG1278	Cold shock
AW19_964	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AW19_965	COG4114	ferric iron reductase
AW19_966	COG0006	proline dipeptidase activity
AW19_967	COG0457	Tetratricopeptide repeat
AW19_968	COG1649	PFAM Uncharacterised BCR, COG1649
AW19_968	COG0726	polysaccharide deacetylase
AW19_969	COG1215	transferase activity, transferring glycosyl groups
AW19_970	COG3658	cytochrome
AW19_973	COG1702	phosphate starvation-inducible protein PhoH
AW19_974	COG0387	Pfam Sodium calcium exchanger
AW19_976	COG0583	DNA-binding transcription factor activity
AW19_977	COG3850	Histidine kinase
AW19_978	COG1294	oxidase, subunit
AW19_979	COG1271	oxidase subunit
AW19_981	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW19_982	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AW19_983	COG3138	arginine N-succinyltransferase
AW19_985	COG3724	N-succinylarginine dihydrolase activity
AW19_986	COG2988	succinylglutamate desuccinylase activity
AW19_989	COG1228	amidohydrolase
AW19_991	COG0402	S-adenosylhomocysteine deaminase activity
AW19_994	COG1129	ABC transporter
AW19_995	COG4211	Belongs to the binding-protein-dependent transport system permease family
AW19_996	COG3443	Belongs to the bacterial solute-binding protein 9 family
AW19_998	COG4942	peptidase