locus-tag class description CEQ36_00025 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CEQ36_00030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CEQ36_00055 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CEQ36_00065 ENOG4105DQR SNARE associated Golgi CEQ36_00075 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CEQ36_00080 ENOG4108S3P Sporulation domain protein CEQ36_00085 ENOG4105E96 Colicin v production protein CEQ36_00090 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CEQ36_00095 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CEQ36_00100 ENOG4105E89 ABC transporter CEQ36_00105 ENOG4105DSP amino acid AbC transporter CEQ36_00110 ENOG4106YG3 ABC transporter CEQ36_00115 ENOG4108JEH abc transporter atp-binding protein CEQ36_00120 ENOG4105ECP epimerase CEQ36_00125 ENOG4108TC0 Diguanylate phosphodiesterase CEQ36_00130 ENOG4108RE9 Phosphodiesterase CEQ36_00135 ENOG4105PTV Nudix Hydrolase CEQ36_00140 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC CEQ36_00150 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia CEQ36_00155 ENOG4107P2S Transcriptional regulator CEQ36_00160 ENOG4105C6K Malic enzyme CEQ36_00170 ENOG4105PQ6 UPF0208 membrane protein CEQ36_00180 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 CEQ36_00185 ENOG4107QWE )-transporter CEQ36_00190 ENOG4105DK2 UPF0207 protein CEQ36_00200 ENOG4105CHM Aminotransferase CEQ36_00205 ENOG4107NQ8 LysR family Transcriptional regulator CEQ36_00220 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEQ36_00225 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEQ36_00230 ENOG4105GKE subunit e CEQ36_00235 ENOG4107QIZ NADH dehydrogenase CEQ36_00240 ENOG4108IEH NADH dehydrogenase subunit g CEQ36_00245 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CEQ36_00250 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEQ36_00255 ENOG4107UFS subunit j CEQ36_00260 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEQ36_00265 ENOG4105D65 subunit l CEQ36_00270 ENOG4105C8S subunit m CEQ36_00275 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEQ36_00285 ENOG4108UQ5 membrane protein YcdZ CEQ36_00290 ENOG4108R66 Conserved Protein CEQ36_00295 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CEQ36_00300 ENOG4105CHR reductase CEQ36_00305 ENOG4105K2J Transcriptional regulator CEQ36_00310 ENOG4105C5I Dehydrogenase CEQ36_00320 ENOG41090KN UPF0303 protein CEQ36_00325 ENOG4105C01 Dihydroxy-acid dehydratase CEQ36_00330 ENOG4105TNS Conserved Protein CEQ36_00335 ENOG4105E4F Isochorismate synthase CEQ36_00340 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CEQ36_00350 ENOG4108IPT Naphthoate synthase CEQ36_00355 ENOG4105DNI Converts SHCHC to OSB (By similarity) CEQ36_00360 ENOG4105CEY Amp-dependent synthetase and ligase CEQ36_00365 ENOG4105CH6 catalase CEQ36_00370 ENOG4108UII YfaZ family CEQ36_00375 ENOG4105E0U tyrosine-specific transport protein CEQ36_00410 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) CEQ36_00415 ENOG4105XPH Ferredoxin CEQ36_00420 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CEQ36_00425 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CEQ36_00430 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CEQ36_00435 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CEQ36_00440 ENOG4105BZU Histidine kinase CEQ36_00445 ENOG41068CG regulatoR CEQ36_00450 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC CEQ36_00455 ENOG4106UW1 Major Facilitator superfamily CEQ36_00470 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CEQ36_00475 ENOG4105CT4 transporter CEQ36_00480 ENOG4105F5H Glycosyl Hydrolase Family 88 CEQ36_00540 ENOG4105CW0 outer membrane usher protein CEQ36_00555 ENOG4105CK2 sodium dicarboxylate symporter CEQ36_00575 ENOG4105DJI Methylaspartate mutase, E subunit CEQ36_00585 ENOG4107WFU Glutamate mutase subunit sigma CEQ36_00590 ENOG4105JZC GHMP kinase CEQ36_00595 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CEQ36_00600 ENOG4105EQ2 LysR family Transcriptional regulator CEQ36_00605 ENOG4107GFK fumarate CEQ36_00610 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CEQ36_00620 ENOG4107R6D beta-lactam binding protein AmpH CEQ36_00625 ENOG4105CT4 transporter CEQ36_00635 ENOG4105C8Q Methyl-accepting chemotaxis CEQ36_00645 ENOG4105Y50 Virulence Protein CEQ36_00660 ENOG4105HRS Antitermination protein CEQ36_00670 ENOG4105KUS lysozyme CEQ36_00690 ENOG4105TKZ Tail Sheath CEQ36_00730 ENOG4108T86 baseplate J family protein CEQ36_00750 ENOG4105HX0 Transcriptional regulator CEQ36_00755 ENOG4105C5Y PTS System CEQ36_00760 ENOG4105CS2 ec 3.2.1.21 CEQ36_00765 ENOG4108UHE carbonic anhydrase CEQ36_00780 ENOG4105E68 Sulfatase CEQ36_00785 ENOG4105PAN UPF0352 protein CEQ36_00790 ENOG4106V8H Nucleoid-associated protein CEQ36_00800 ENOG4105CFI type iii restriction protein res subunit CEQ36_00805 ENOG4105I08 Pseudouridine synthase CEQ36_00810 ENOG4105C2C drug resistance transporter, Bcr CflA CEQ36_00820 ENOG4105HG6 CEQ36_00825 ENOG4108JQ5 ABC transporter CEQ36_00830 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component CEQ36_00835 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component CEQ36_00840 ENOG4105E43 Extracellular solute-binding protein, family 5 CEQ36_00845 ENOG4105CXC rtn protein CEQ36_00850 ENOG4107TT5 NLP P60 protein CEQ36_00855 ENOG41076MN Phosphoesterase, PA-phosphatase related CEQ36_00860 ENOG4105CKI cobalamin synthesis protein CEQ36_00870 ENOG4107YCY Transcriptional regulator CEQ36_00875 ENOG4105DEI Mannitol dehydrogenase CEQ36_00885 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CEQ36_00890 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CEQ36_00900 ENOG4105KRS Proteinase inhibitor CEQ36_00910 ENOG4105D2N Aldolase CEQ36_00915 ENOG4105E70 isomerase CEQ36_00920 ENOG4105CE4 GlcNAc 6-P deacetylase CEQ36_00925 ENOG4108YTN IIa component CEQ36_00930 ENOG4105F3R pts system mannose fructose sorbose family iid CEQ36_00940 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB CEQ36_00945 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of CEQ36_00950 ENOG4105E98 transcriptional regulator DeoR family CEQ36_00955 ENOG4108J2R molybdopterin oxidoreductase CEQ36_00960 ENOG4105CUW cytochrome C-TYPE protein CEQ36_00970 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CEQ36_00975 ENOG4105DE4 1-phosphofructokinase CEQ36_00980 ENOG4105DM4 PTS System CEQ36_00985 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CEQ36_00990 ENOG4105HMI Membrane CEQ36_01000 ENOG4105DUM transcriptional regulator, lysR family CEQ36_01005 ENOG4108IQI permease CEQ36_01010 ENOG4105D05 Receptor CEQ36_01015 ENOG4108TGY Glutathione S-transferase CEQ36_01030 ENOG4105D01 (LipO)protein CEQ36_01040 ENOG4108UMI ABC transporter, permease CEQ36_01045 ENOG4105C28 cystathionine CEQ36_01055 ENOG4105DZ1 carboxypeptidase CEQ36_01060 ENOG4105EJQ L-serine dehydratase CEQ36_01065 ENOG4105C44 Serine transporter CEQ36_01075 ENOG4107FB0 transcriptional regulator DeoR family CEQ36_01080 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CEQ36_01085 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CEQ36_01095 ENOG4105D0C transport protein CEQ36_01100 ENOG41090BQ Glutaredoxin CEQ36_01105 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress CEQ36_01110 ENOG4108RMJ sensory transduction regulator CEQ36_01115 ENOG4107RUE extracellular solute-binding protein family 1 CEQ36_01120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CEQ36_01125 ENOG4105F38 ABC transporter, permease CEQ36_01130 ENOG4105D38 putrescine abc transporter CEQ36_01135 ENOG4105RBQ inner membrane protein ybjO CEQ36_01145 ENOG4106TNF Periplasmic binding protein CEQ36_01150 ENOG4108NNI Beta-lactamase domain-containing protein CEQ36_01155 ENOG4105C0A alcohol dehydrogenase CEQ36_01160 ENOG4105C26 Dehydrogenase CEQ36_01165 ENOG4108FUF Transcriptional regulator, IclR family CEQ36_01170 ENOG4105DMR ABC, transporter CEQ36_01175 ENOG4105GBT ABC transporter CEQ36_01180 ENOG4106PMH Extracellular solute-binding protein family 3 CEQ36_01185 ENOG4105E5Z arginine transporter ATP-binding subunit CEQ36_01195 ENOG41064MM (LipO)protein CEQ36_01200 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase CEQ36_01205 ENOG4105CGD Nad-dependent epimerase dehydratase CEQ36_01210 ENOG4105C5W Aldolase CEQ36_01220 ENOG4105C7K acetolactate synthase CEQ36_01225 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CEQ36_01230 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CEQ36_01235 ENOG4105DWU Membrane CEQ36_01240 ENOG4105CPB ATP-dependent endonuclease of the OLD family CEQ36_01245 ENOG4108MJ5 VirK protein CEQ36_01250 ENOG4105DJY efflux transporter, rnd family, mfp subunit CEQ36_01260 ENOG4105VEQ Cold shock protein CEQ36_01265 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CEQ36_01270 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CEQ36_01275 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CEQ36_01285 ENOG4108JJ8 (ABC) transporter CEQ36_01290 ENOG4108JJ9 ABC, transporter CEQ36_01295 ENOG4105C3M thioredoxin reductase CEQ36_01300 ENOG4105EW9 transcriptional regulator AsnC family CEQ36_01305 ENOG4105CNU cell division protein FtsK CEQ36_01310 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) CEQ36_01315 ENOG4105D1H recombination factor protein RarA CEQ36_01320 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CEQ36_01325 ENOG4108ISG Major Facilitator CEQ36_01330 ENOG4105F1A Pyruvate formate-lyase CEQ36_01335 ENOG4105C6N Formate acetyltransferase CEQ36_01340 ENOG4105TMB Formate nitrite transporter CEQ36_01345 ENOG4105DDY UPF0142 protein ycaO CEQ36_01350 ENOG4105HDK L-asparaginase CEQ36_01360 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CEQ36_01375 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CEQ36_01380 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CEQ36_01385 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 CEQ36_01395 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) CEQ36_01400 ENOG4105E32 cytoplasmic protein CEQ36_01405 ENOG4105VEQ Cold shock protein CEQ36_01410 ENOG4105VEQ Cold shock protein CEQ36_01415 ENOG4105W49 UPF0434 protein CEQ36_01425 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups CEQ36_01435 ENOG4107S90 membrAne CEQ36_01445 ENOG4106371 Methyltransferase CEQ36_01450 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) CEQ36_01455 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) CEQ36_01460 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) CEQ36_01465 ENOG4105DIT ErfK YbiS YcfS YnhG family protein CEQ36_01470 ENOG4105EAQ (twin-arginine translocation) pathway signal CEQ36_01475 ENOG4105C5X domain protein CEQ36_01480 ENOG4105BZU Histidine kinase CEQ36_01485 ENOG4105CGF Aromatic amino acid aminotransferase CEQ36_01495 ENOG4105C5S asparaginyl-tRNA synthetase CEQ36_01500 ENOG4107RH7 Nicotinate phosphoribosyltransferase CEQ36_01510 ENOG4105CD8 aminopeptidase N CEQ36_01515 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CEQ36_01525 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) CEQ36_01530 ENOG4105QVC MOSC domain-containing protein CEQ36_01535 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CEQ36_01540 ENOG4105C5H ABC transporter CEQ36_01545 ENOG4105F1S paraquat-inducible protein a CEQ36_01550 ENOG4105DY2 Paraquat-inducible protein b CEQ36_01555 ENOG4108Q2G (LipO)protein CEQ36_01560 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) CEQ36_01565 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CEQ36_01575 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) CEQ36_01580 ENOG4105DAN ATP-dependent protease CEQ36_01585 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) CEQ36_01590 ENOG4105UYK outer membrane protein a CEQ36_01595 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) CEQ36_01600 ENOG4108RZ1 DNA transformation protein CEQ36_01605 ENOG4105EM2 membrane CEQ36_01610 ENOG410901E Membrane CEQ36_01615 ENOG41088T4 Helicase IV CEQ36_01625 ENOG4108Q67 UPF0319 protein CEQ36_01630 ENOG4105K4P CoA-binding domain protein CEQ36_01635 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) CEQ36_01645 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 CEQ36_01650 ENOG4108Z0T Part of a sulfur-relay system (By similarity) CEQ36_01675 ENOG41066DG (EAL) domain protein CEQ36_01680 ENOG4108VCD Chaperone CEQ36_01695 ENOG4105GQR Chaperone CEQ36_01740 ENOG4105ETX regulatoR CEQ36_01745 ENOG41083UI stage II sporulation protein CEQ36_01760 ENOG4107QZ7 Cellulose synthase catalytic subunit CEQ36_01780 ENOG4105CNT hydrolase family 2 CEQ36_01785 ENOG4105BZU Histidine kinase CEQ36_01790 ENOG4105BZU Histidine kinase CEQ36_01795 ENOG4107653 Transcriptional regulator CEQ36_01805 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region CEQ36_01810 ENOG41060W2 glyoxylate carboligase CEQ36_01815 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CEQ36_01820 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CEQ36_01825 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease CEQ36_01835 ENOG4105DTE Xanthine uracil vitamin C permease CEQ36_01840 ENOG4105BZW Glycerate kinase CEQ36_01845 ENOG4105S0E allantoin catabolism protein CEQ36_01850 ENOG4105CE7 Amidase, hydantoinase carbamoylase family CEQ36_01855 ENOG4105DG4 malate L-lactate dehydrogenase CEQ36_01860 ENOG4107R1Q Membrane protein FdrA CEQ36_01865 ENOG4107REC cytoplasmic protein CEQ36_01870 ENOG4105G5A Protein of unknown function (DUF2877) CEQ36_01875 ENOG4105C5B carbamate kinase CEQ36_01895 ENOG4105TNG K13735 adhesin invasin CEQ36_01915 ENOG4105CVK Glutamate decarboxylase CEQ36_01920 ENOG4105E5D amino acid CEQ36_01925 ENOG4105CSV Glutaminase CEQ36_01930 ENOG4105VJY transcriptional regulator CEQ36_01935 ENOG4107YC3 synthase CEQ36_01965 ENOG4105DJ9 glucan biosynthesis protein CEQ36_01970 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) CEQ36_01975 ENOG4105NAC (LipO)protein CEQ36_01990 ENOG4105DUX Transporter CEQ36_01995 ENOG4105C6X Major Facilitator CEQ36_02000 ENOG4108VGI doxx family CEQ36_02005 ENOG4105D1S lipid A biosynthesis CEQ36_02010 ENOG4108ZXC Two component transcriptional regulator, luxr family CEQ36_02015 ENOG4106AFQ Histidine kinase CEQ36_02020 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CEQ36_02025 ENOG4106WHD Tetrathionate reductase CEQ36_02030 ENOG4105DB1 molybdopterin oxidoreductase CEQ36_02045 ENOG4105DSF transport protein CEQ36_02065 ENOG4105PVA Biofilm formation regulatory protein BssS CEQ36_02075 ENOG4105EKE dihydroorotase CEQ36_02080 ENOG41067V3 Antibiotic biosynthesis monooxygenase CEQ36_02085 ENOG4107QQB Ribonuclease E CEQ36_02090 ENOG4105EI2 Pseudouridine synthase CEQ36_02100 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein CEQ36_02105 ENOG4105VGS 50s ribosomal protein l32 CEQ36_02110 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CEQ36_02120 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CEQ36_02125 ENOG4105CHR reductase CEQ36_02135 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CEQ36_02140 ENOG4105YAZ 4-amino-4-deoxychorismate lyase CEQ36_02145 ENOG4105HHA aminodeoxychorismate lyase CEQ36_02150 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CEQ36_02155 ENOG4107QRG dna polymerase iii CEQ36_02160 ENOG4105F8V Hydrolase, tatD family CEQ36_02165 ENOG4105CI1 PTS System CEQ36_02175 ENOG4105K59 histidine triad (HIT) protein CEQ36_02180 ENOG41090DQ Lipoprotein CEQ36_02185 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) CEQ36_02200 ENOG4105D0Y UPF0227 protein CEQ36_02205 ENOG4105CEP NADH dehydrogenase CEQ36_02210 ENOG4107MBR 17 kDa surface antigen CEQ36_02215 ENOG4108JA2 transcriptioN-repair coupling factor CEQ36_02220 ENOG4105D60 lipoprotein releasing system transmembrane protein CEQ36_02230 ENOG4105D60 lipoprotein releasing system transmembrane protein CEQ36_02240 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) CEQ36_02245 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CEQ36_02255 ENOG4105EZE Cupin 4 family protein CEQ36_02265 ENOG4105XJC Two component transcriptional regulator (Winged helix family CEQ36_02275 ENOG4107QTF adenylosuccinate lyase CEQ36_02280 ENOG41075W9 High frequency lysogenization protein HflD homolog CEQ36_02285 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CEQ36_02295 ENOG4108R99 pseudouridine synthase CEQ36_02300 ENOG4108HMX isocitrate dehydrogenase (NADP) CEQ36_02320 ENOG4108M1A Chitin-binding protein CEQ36_02330 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor CEQ36_02340 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CEQ36_02345 ENOG4105KT5 UmuD protein CEQ36_02350 ENOG4108IQK o-acetylhomoserine CEQ36_02355 ENOG4105ECR NmrA family CEQ36_02360 ENOG4105KVH Transcriptional regulator CEQ36_02370 ENOG4105DWP Membrane CEQ36_02380 ENOG4105VTN Protein of unknown function (DUF1311) CEQ36_02385 ENOG4105XXV Acid-resistance protein CEQ36_02405 ENOG4105BZ1 (ABC) transporter CEQ36_02415 ENOG4105D5Q Arginine ornithine antiporter CEQ36_02430 ENOG4105N4N Protein of unknown function (DUF2766) CEQ36_02435 ENOG4105TIK CEQ36_02445 ENOG41064PC CEQ36_02460 ENOG4105C85 amino acid CEQ36_02465 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) CEQ36_02470 ENOG410610J Protein of unknown function (DUF2627) CEQ36_02475 ENOG4105VEQ Cold shock protein CEQ36_02480 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CEQ36_02485 ENOG4105CJN penicillin-binding protein CEQ36_02490 ENOG4105DHI Methyltransferase CEQ36_02500 ENOG4105BZU Histidine kinase CEQ36_02515 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) CEQ36_02520 ENOG4108NK4 UPF0266 membrane protein CEQ36_02525 ENOG4105F3R pts system mannose fructose sorbose family iid CEQ36_02530 ENOG4105ETZ PTS System CEQ36_02535 ENOG4108EQA pts system CEQ36_02540 ENOG4105EE5 Membrane protein terC CEQ36_02545 ENOG4105EJQ L-serine dehydratase CEQ36_02550 ENOG4105P8F nudix hydrolase CEQ36_02560 ENOG4105X5C UPF0181 protein CEQ36_02565 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CEQ36_02570 ENOG4105C1J atp-dependent rna helicase CEQ36_02575 ENOG4105X2V dna damage-inducible protein CEQ36_02580 ENOG4105N5Z UPF0267 protein CEQ36_02590 ENOG4105CUG Oligopeptidase b CEQ36_02595 ENOG4105UMD exodeoxyribonuclease X CEQ36_02605 ENOG4105MPK DNA polymerase III subunit theta CEQ36_02610 ENOG41090A1 ferritin CEQ36_02615 ENOG4105FXM Copper resistance protein CEQ36_02620 ENOG4108PNC copper resistance CEQ36_02625 ENOG4105NKT exported protein CEQ36_02630 ENOG4108I1J Integrase CEQ36_02675 ENOG41087BU transcriptional repressor DicA CEQ36_02735 ENOG4105RWQ Protein of unknown function (DUF1364) CEQ36_02740 ENOG4105HRS Antitermination protein CEQ36_02760 ENOG41060V2 Acid-resistance protein CEQ36_02970 ENOG4108RS6 transposase CEQ36_02995 ENOG4108RW8 Universal stress protein F CEQ36_03005 ENOG4105CUY Mechanosensitive ion channel CEQ36_03010 ENOG4105FE9 pseudouridine synthase CEQ36_03020 ENOG4108RNG Permease of the drug metabolite transporter CEQ36_03040 ENOG4108SHQ Glutathione S-transferase CEQ36_03065 ENOG4105WT8 Protein of unknown function (DUF1480) CEQ36_03075 ENOG4105C0R drug resistance transporter emrb qaca subfamily CEQ36_03085 ENOG4105DY2 Paraquat-inducible protein b CEQ36_03090 ENOG4105H2K paraquat-inducible protein a CEQ36_03095 ENOG4108ZGC gaf domain protein CEQ36_03105 ENOG4105CN1 protease CEQ36_03110 ENOG4105D0M Protease HtpX homolog CEQ36_03115 ENOG4105C0R drug resistance transporter emrb qaca subfamily CEQ36_03120 ENOG4105CAZ oligogalacturonide lyase CEQ36_03130 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CEQ36_03135 ENOG4108ETY sodium dicarboxylate symporter CEQ36_03140 ENOG4107K5X Membrane-bound metal-dependent hydrolase CEQ36_03145 ENOG4108PU9 oligogalacturonate-specific porin CEQ36_03160 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CEQ36_03165 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CEQ36_03170 ENOG41061NF Pectate lyase CEQ36_03175 ENOG4105CHR reductase CEQ36_03185 ENOG4105M5J Cupin 2, conserved barrel domain protein CEQ36_03190 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 CEQ36_03195 ENOG4107PN8 YfeABCD locus regulator CEQ36_03200 ENOG4105DEQ transcriptional regulator CEQ36_03205 ENOG4105CYC Transferase CEQ36_03210 ENOG4108M7F enoyl-CoA hydratase isomerase CEQ36_03215 ENOG4105DJT lAO AO transport system ATPase CEQ36_03220 ENOG4105D5P Methylmalonyl-coA mutase CEQ36_03225 ENOG4105FGM Fructosamine kinase CEQ36_03230 ENOG4105CC5 ABC transporter CEQ36_03235 ENOG4105CC5 ABC transporter CEQ36_03240 ENOG4105DIK (ABC) transporter CEQ36_03245 ENOG4105DSE periplasmic solute binding protein CEQ36_03255 ENOG41082NP Multiple antibiotic resistance CEQ36_03280 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase CEQ36_03285 ENOG4105H6Q decarboxylase CEQ36_03290 ENOG4105CMG Carbohydrate kinase CEQ36_03295 ENOG4105DG4 malate L-lactate dehydrogenase CEQ36_03310 ENOG4105CNN ABC, transporter CEQ36_03315 ENOG4105C2J ABC transporter CEQ36_03320 ENOG4105J4Q Transcriptional regulator CEQ36_03325 ENOG4108UQV Membrane CEQ36_03330 ENOG41087WU CEQ36_03340 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CEQ36_03345 ENOG41082NX 50s ribosomal protein l35 CEQ36_03365 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CEQ36_03375 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) CEQ36_03380 ENOG4108V06 Glutathione peroxidase CEQ36_03385 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) CEQ36_03390 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CEQ36_03395 ENOG4105CKK Glycosyl transferase, family 2 CEQ36_03405 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) CEQ36_03410 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) CEQ36_03415 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CEQ36_03420 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CEQ36_03425 ENOG4108QBX (LipO)protein CEQ36_03430 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) CEQ36_03440 ENOG4107R4I Periplasmic binding protein CEQ36_03445 ENOG4106QJH hemin transport protein CEQ36_03450 ENOG4107ENK receptor CEQ36_03455 ENOG4107F3C Hemin uptake protein CEQ36_03460 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CEQ36_03465 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CEQ36_03475 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CEQ36_03485 ENOG4105IPI Membrane CEQ36_03490 ENOG4105CQB FAD linked oxidase domain protein CEQ36_03495 ENOG4105KA0 thioesterase Superfamily protein CEQ36_03505 ENOG4108Z4V iron-sulfur cluster assembly CEQ36_03510 ENOG4105DIW FeS assembly protein SUFB CEQ36_03515 ENOG4105C3K feS assembly ATPase SufC CEQ36_03520 ENOG4105JRK feS assembly protein SufD CEQ36_03530 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CEQ36_03535 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CEQ36_03540 ENOG4105KMX major outer membrane lipoprotein CEQ36_03545 ENOG4105CA9 Pyruvate kinase CEQ36_03565 ENOG4107QI1 Mate efflux family protein CEQ36_03570 ENOG4108R6K riboflavin synthase, subunit alpha CEQ36_03575 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CEQ36_03580 ENOG4105CZQ inner membrane transport protein YdhC CEQ36_03585 ENOG4105F52 Transcriptional regulator CEQ36_03590 ENOG4105ETE Transcriptional regulator (LacI family CEQ36_03600 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CEQ36_03605 ENOG4105K4H Nlp p60 protein CEQ36_03610 ENOG4105M2J Glutaredoxin CEQ36_03615 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) CEQ36_03620 ENOG4108UYE Lactoylglutathione lyase CEQ36_03625 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CEQ36_03630 ENOG4108WUH Transcriptional regulator, TetR family CEQ36_03635 ENOG4105DIJ Phosphoethanolamine transferase CEQ36_03640 ENOG4105XZD Fe-S protein CEQ36_03645 ENOG4107RGM aldo keto reductase CEQ36_03650 ENOG4105DSW Fusaric acid resistance protein CEQ36_03655 ENOG4105Y49 secretion protein, HlyD family CEQ36_03665 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) CEQ36_03670 ENOG4108XTF Outer Membrane Lipoprotein CEQ36_03675 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CEQ36_03680 ENOG410642K Lysozyme inhibitor CEQ36_03690 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CEQ36_03700 ENOG4108K3A Glutathione S-transferase CEQ36_03705 ENOG4108ZR5 Conserved Protein CEQ36_03710 ENOG41069YE inner membrane protein yohC CEQ36_03720 ENOG4105DUX Transporter CEQ36_03725 ENOG4105DUM transcriptional regulator, lysR family CEQ36_03730 ENOG4105Q4T oxidoreductase CEQ36_03740 ENOG4108JQ2 peptide transport system atp-binding protein CEQ36_03745 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein CEQ36_03750 ENOG4108EU3 peptide transport system, permease CEQ36_03755 ENOG4108I5W peptide transport system, permease protein CEQ36_03760 ENOG4108HIY periplasmic CEQ36_03780 ENOG4105E51 psp operon transcriptional activator CEQ36_03785 ENOG41087YS Phage shock protein A CEQ36_03790 ENOG4105YYT phage shock protein B CEQ36_03795 ENOG4105FM1 phage shock protein C CEQ36_03805 ENOG4105CM6 amino acid regulated cytosolic protein CEQ36_03810 ENOG4106K28 UPF0283 membrane protein CEQ36_03830 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CEQ36_03835 ENOG4107S8C mandelate racemase muconate lactonizing CEQ36_03840 ENOG4105KXI murein peptide amidase A CEQ36_03845 ENOG4107QSI ABC, transporter CEQ36_03850 ENOG4107RX3 Mg2 transporter protein cora family protein CEQ36_03855 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) CEQ36_03860 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) CEQ36_03870 ENOG4105KT7 mgtC SapB transporter CEQ36_03880 ENOG4105C5I Dehydrogenase CEQ36_03885 ENOG4107H52 Dicarboxylate transport CEQ36_03890 ENOG410689M (LipO)protein CEQ36_03895 ENOG4105WXT Conserved Protein CEQ36_03900 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CEQ36_03905 ENOG4105CQ7 ATP-dependent helicase CEQ36_03920 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap CEQ36_03930 ENOG4105CTD carboxy-peptidase CEQ36_03935 ENOG4105JJR Histidine kinase CEQ36_03940 ENOG4107EXC regulatoR CEQ36_03950 ENOG4105D5Q Arginine ornithine antiporter CEQ36_03955 ENOG4105C5D exported protein CEQ36_03965 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CEQ36_03970 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CEQ36_03975 ENOG4105Q9Y Universal stress protein CEQ36_03980 ENOG4105DS0 Transcriptional regulator, Crp Fnr family CEQ36_03985 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CEQ36_04000 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) CEQ36_04010 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CEQ36_04020 ENOG4108RVA ribokinase CEQ36_04025 ENOG4105EDR glucose galactose transporter CEQ36_04040 ENOG4105ETT transcriptional Regulator, LysR family CEQ36_04050 ENOG4105PAD Hydrolase CEQ36_04055 ENOG4105KME endoribonuclease L-psp CEQ36_04060 ENOG4105M71 acetolactate synthase 1 regulatory subunit CEQ36_04065 ENOG4105C7K acetolactate synthase CEQ36_04095 ENOG4105FYV Amp nucleosidase CEQ36_04105 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) CEQ36_04110 ENOG4105CJ2 (LipO)protein CEQ36_04115 ENOG4106V2I dimethylaminohydrolase CEQ36_04120 ENOG4105E89 ABC transporter CEQ36_04125 ENOG4105DSP amino acid AbC transporter CEQ36_04135 ENOG4108RYR transcriptional regulator AsnC family CEQ36_04145 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase CEQ36_04150 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center CEQ36_04155 ENOG4108JUA Transcriptional regulator CEQ36_04160 ENOG4105CYM Glutathione S-transferase CEQ36_04190 ENOG4105K89 arsenate reductase CEQ36_04210 ENOG4105F32 YngK protein CEQ36_04215 ENOG4105EQK -acetyltransferase CEQ36_04220 ENOG4105EMU Dehydrogenase CEQ36_04230 ENOG4105KK4 UPF0060 membrane protein CEQ36_04235 ENOG4105M5Q UPF0482 protein CEQ36_04240 ENOG4105KBG Protein of unknown function (DUF1161) CEQ36_04250 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CEQ36_04255 ENOG4105DAG ROK family CEQ36_04260 ENOG4106NZI LysR family Transcriptional regulator CEQ36_04265 ENOG4105D94 Major Facilitator Superfamily CEQ36_04280 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) CEQ36_04285 ENOG4105C9Q fumarate hydratase class II CEQ36_04290 ENOG4105EIP mannose-6-phosphate isomerase CEQ36_04295 ENOG4106J39 exported protein CEQ36_04305 ENOG4107P2S Transcriptional regulator CEQ36_04310 ENOG4105CI1 PTS System CEQ36_04315 ENOG4105C87 Aminotransferase class I and II CEQ36_04320 ENOG4105FDP GntR family transcriptional regulator CEQ36_04325 ENOG4105CXK mandelate racemase muconate lactonizing CEQ36_04330 ENOG4105C5Y PTS System CEQ36_04335 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CEQ36_04340 ENOG4105DHU Bile acid CEQ36_04345 ENOG4105D9R oxidoreductase CEQ36_04355 ENOG4105CNN ABC, transporter CEQ36_04365 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator CEQ36_04380 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CEQ36_04390 ENOG4108JJA ABC, transporter CEQ36_04395 ENOG4105C42 Type I secretion membrane fusion protein (HlyD CEQ36_04400 ENOG4108JJA ABC, transporter CEQ36_04405 ENOG4105CKU formyltetrahydrofolate synthetase CEQ36_04410 ENOG4105M9B inner membrane protein ydgK CEQ36_04415 ENOG4105DGN Electron transport complex CEQ36_04425 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CEQ36_04430 ENOG4105UEI Transcriptional Regulator AraC Family CEQ36_04435 ENOG4105D6A Electron transport complex CEQ36_04440 ENOG4108UQQ Electron transport complex CEQ36_04450 ENOG4105CSM endonuclease III CEQ36_04455 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit CEQ36_04460 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) CEQ36_04470 ENOG4105D22 carbon starvation protein CEQ36_04475 ENOG4105VCD cytoplasmic protein CEQ36_04480 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CEQ36_04485 ENOG4105N2W Transcriptional regulator CEQ36_04495 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase CEQ36_04500 ENOG41061RM osmotically inducible lipoprotein CEQ36_04505 ENOG4108ZJT translation initiation factor, Sui1 CEQ36_04515 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction CEQ36_04525 ENOG4105CFV Tetratricopeptide repeat protein CEQ36_04530 ENOG4105Q4A inner membrane protein yciS CEQ36_04535 ENOG4105EYK Phosphatidylglycerophosphatase B CEQ36_04540 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) CEQ36_04545 ENOG4107QM5 aconitate hydratase CEQ36_04555 ENOG4107R11 Transcriptional regulator CEQ36_04560 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CEQ36_04565 ENOG4105RKX Protein of unknown function (DUF2498) CEQ36_04570 ENOG4105ERU peptidase CEQ36_04575 ENOG4105UBK short-chain dehydrogenase reductase CEQ36_04580 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CEQ36_04590 ENOG4105FE9 pseudouridine synthase CEQ36_04600 ENOG4107RTD sua5 ycio yrdc ywlc family protein CEQ36_04605 ENOG4105DB7 PHP domain protein CEQ36_04620 ENOG4105DDQ anthranilate synthase CEQ36_04630 ENOG4105DK0 Indole-3-glycerol phosphate synthase CEQ36_04635 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CEQ36_04640 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CEQ36_04645 ENOG4105W4M Transport-associated protein CEQ36_04650 ENOG4105EIF outer membrane protein W CEQ36_04655 ENOG4105PI0 Ferredoxin CEQ36_04660 ENOG4108S3I UPF0259 membrane protein CEQ36_04670 ENOG4107835 probably involved in intracellular septation (By similarity) CEQ36_04675 ENOG4105NAU thioesterase Superfamily protein CEQ36_04680 ENOG410822N TonB family CEQ36_04685 ENOG4105K9H YciI-like protein CEQ36_04710 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CEQ36_04715 ENOG4108W5H UPF0263 protein CEQ36_04720 ENOG4108JQ7 (ABC) transporter CEQ36_04725 ENOG4105C3U ABC transporter CEQ36_04730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CEQ36_04735 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CEQ36_04740 ENOG4107QSI ABC, transporter CEQ36_04745 ENOG4108J59 Extracellular solute-binding protein, family 5 CEQ36_04750 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CEQ36_04760 ENOG4108EKI Dehydrogenase CEQ36_04765 ENOG4107104 thymidine kinase CEQ36_04775 ENOG4105C6Y Udp-glucose 6-dehydrogenase CEQ36_04780 ENOG4105I93 response regulator CEQ36_04785 ENOG4105D78 K07001 NTE family protein CEQ36_04795 ENOG4105K5B UPF0225 protein CEQ36_04800 ENOG4105CIY formyltetrahydrofolate deformylase CEQ36_04840 ENOG4105CGK Exodeoxyribonuclease III CEQ36_04845 ENOG4105M6F mutator MutT protein CEQ36_04850 ENOG4105MTM Protein of unknown function (DUF1496) CEQ36_04855 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CEQ36_04865 ENOG41069NU Nitroreductase CEQ36_04870 ENOG4105D07 Signal peptide peptidase, SppA CEQ36_04875 ENOG4105HDK L-asparaginase CEQ36_04880 ENOG4108RWI nicotinamidase CEQ36_04885 ENOG4105VUT cytoplasmic protein CEQ36_04900 ENOG4105DSB aldose 1-epimerase CEQ36_04905 ENOG4105GNX MltA-interacting MipA family protein CEQ36_04915 ENOG4105CYN Serine protein kinase CEQ36_04920 ENOG4106AKX UPF0229 protein CEQ36_04930 ENOG4105BZU Histidine kinase CEQ36_04935 ENOG4105CNH Multidrug resistance protein MdtL CEQ36_04940 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CEQ36_04945 ENOG4105MWK D-amino acid dehydrogenase, small subunit CEQ36_04950 ENOG4105ED1 spovr family CEQ36_04955 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) CEQ36_04960 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CEQ36_04965 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) CEQ36_04970 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CEQ36_04980 ENOG4108ZZ3 UPF0260 protein CEQ36_04985 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase CEQ36_04990 ENOG4105CVE Lytic murein transglycosylase CEQ36_04995 ENOG4105VNG YcgL domain-containing protein CEQ36_05005 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CEQ36_05010 ENOG4107QMS site-determining protein CEQ36_05015 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) CEQ36_05020 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) CEQ36_05025 ENOG4105CEY Amp-dependent synthetase and ligase CEQ36_05030 ENOG4105Y4Z Outer Membrane Lipoprotein CEQ36_05035 ENOG41072GX Peptidase M22 Glycoprotease CEQ36_05040 ENOG4105DVT helicase CEQ36_05045 ENOG4105M4H endoribonuclease L-psp CEQ36_05055 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) CEQ36_05060 ENOG4108UHU Aldolase CEQ36_05070 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CEQ36_05075 ENOG4106KNT transcriptional regulator CEQ36_05080 ENOG4105CA9 Pyruvate kinase CEQ36_05085 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase CEQ36_05090 ENOG4105DR5 peptidase CEQ36_05095 ENOG4105NXV High-affinity zinc uptake system protein CEQ36_05100 ENOG4105FDK ABC transporter CEQ36_05105 ENOG4105FAV ABC, transporter CEQ36_05110 ENOG4105DUX Transporter CEQ36_05115 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CEQ36_05120 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CEQ36_05130 ENOG4105CDY transcriptional regulatory protein CEQ36_05135 ENOG4108TIT dATP pyrophosphohydrolase CEQ36_05140 ENOG4105C9M aspartyl-trna synthetase CEQ36_05145 ENOG4105D3W isochorismatase CEQ36_05150 ENOG41081XQ Conserved Protein CEQ36_05155 ENOG4105WJG Glutathione CEQ36_05170 ENOG4106N3A copper homeostasis protein cutc CEQ36_05175 ENOG4106ZCM YecM protein CEQ36_05205 ENOG4105CJR Integral membrane protein (MviN CEQ36_05210 ENOG4105EP9 oxidoreductase CEQ36_05220 ENOG4105D9U N-acetyltransferase CEQ36_05225 ENOG4105EV4 Multidrug resistance protein mdtH CEQ36_05230 ENOG4105F3T (LipO)protein CEQ36_05235 ENOG4107XHZ cytoplasmic chaperone TorD family protein CEQ36_05245 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase CEQ36_05270 ENOG4105BZU Histidine kinase CEQ36_05275 ENOG4105CHH sulfate transporter CEQ36_05285 ENOG41063JG Transcriptional regulator CEQ36_05290 ENOG4108YY7 Invasion gene expression up-regulator SirB CEQ36_05295 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CEQ36_05300 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CEQ36_05305 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CEQ36_05310 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) CEQ36_05320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CEQ36_05325 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria CEQ36_05330 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CEQ36_05340 ENOG4105C3G gtp-binding protein CEQ36_05350 ENOG4108K5P (LipO)protein CEQ36_05360 ENOG4108MEK Metal-binding protein YodA CEQ36_05365 ENOG4108HWV )-transporter CEQ36_05385 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CEQ36_05390 ENOG4105CZE histidine utilization repressor CEQ36_05395 ENOG4105CI2 imidazolone-5-propionate hydrolase CEQ36_05415 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) CEQ36_05425 ENOG4105F4X arginine CEQ36_05430 ENOG4105C8Y Acetylornithine aminotransferase CEQ36_05435 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CEQ36_05440 ENOG4105C4M (Ubiquinol oxidase) subunit I CEQ36_05445 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CEQ36_05455 ENOG4105BZU Histidine kinase CEQ36_05460 ENOG4107R11 Transcriptional regulator CEQ36_05465 ENOG4105F27 Major Facilitator CEQ36_05475 ENOG4105EWV Sodium calcium exchanger membrane region CEQ36_05480 ENOG4105D5M phosphate starvation-inducible protein CEQ36_05495 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD CEQ36_05500 ENOG4105CND Glycosyl transferase, family 2 CEQ36_05505 ENOG4107BJW polysaccharide deacetylase CEQ36_05510 ENOG4108TUY outer membrane protein PgaA CEQ36_05515 ENOG4105DC7 peptidase M24 CEQ36_05520 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CEQ36_05525 ENOG4105EXG Transcriptional regulator CEQ36_05545 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEQ36_05555 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEQ36_05570 ENOG4107SJW iron permease, FTR1 CEQ36_05580 ENOG4105VCP PTS System CEQ36_05585 ENOG4105CS2 ec 3.2.1.21 CEQ36_05590 ENOG4105CK1 PTS System CEQ36_05595 ENOG4105VZJ PTS System CEQ36_05600 ENOG4105DDV Transcriptional regulator (LacI family CEQ36_05610 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CEQ36_05615 ENOG4105FB2 class II Aldolase CEQ36_05620 ENOG4105G63 Type III effector Hrp-dependent CEQ36_05625 ENOG4105ZXK Dehydrogenase CEQ36_05630 ENOG4105MVE transcriptional regulator CEQ36_05635 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CEQ36_05640 ENOG4108MRH transcriptional regulatory protein CEQ36_05650 ENOG4105C85 amino acid CEQ36_05655 ENOG41076YT nitrate reductase, gamma subunit CEQ36_05660 ENOG4105R3A Nitrate reductase CEQ36_05665 ENOG4108IUE nitrate reductase beta subunit CEQ36_05670 ENOG4105CRU nitrate reductase, alpha subunit CEQ36_05675 ENOG4105DQQ Major facilitator superfamily MFS_1 CEQ36_05680 ENOG4105WH1 Two component transcriptional regulator luxr family CEQ36_05700 ENOG4106UW1 Major Facilitator superfamily CEQ36_05705 ENOG4108HCJ Hydrolase CEQ36_05710 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CEQ36_05725 ENOG4108N8T regulatoR CEQ36_05740 ENOG4106PG1 outer membrane usher protein CEQ36_05745 ENOG4108FZ9 Chaperone CEQ36_05870 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CEQ36_05875 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CEQ36_05880 ENOG4105WH1 Two component transcriptional regulator luxr family CEQ36_05885 ENOG4105XVG cytoplasmic protein CEQ36_05890 ENOG4105RA2 Membrane CEQ36_05900 ENOG4105C8Q Methyl-accepting chemotaxis CEQ36_05905 ENOG4105E5K Alpha-amylase CEQ36_05930 ENOG410620I Diguanylate cyclase CEQ36_05935 ENOG4108KU3 Integrase CEQ36_05960 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CEQ36_06000 ENOG4105VZ1 Replication Protein CEQ36_06035 ENOG4105ED4 portal protein CEQ36_06130 ENOG4105UZW Tail fiber assembly protein CEQ36_06190 ENOG4108V1U phospholipid-binding protein CEQ36_06220 ENOG4105CK7 Sodium proline symporter CEQ36_06225 ENOG4105C26 Dehydrogenase CEQ36_06240 ENOG4105CDA abc transporter atp-binding protein CEQ36_06245 ENOG4105E5Q amino acid AbC transporter CEQ36_06250 ENOG4105EAB amino acid AbC transporter CEQ36_06255 ENOG4105K6H D-cysteine desulfhydrase CEQ36_06260 ENOG4108M9K flagella biosynthesis protein FliZ CEQ36_06265 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CEQ36_06275 ENOG4105DTS flagellar hook-associated CEQ36_06280 ENOG4105MQ3 flagellar protein FliS CEQ36_06285 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) CEQ36_06295 ENOG4105DHT Metal Dependent Phosphohydrolase CEQ36_06305 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CEQ36_06310 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CEQ36_06315 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CEQ36_06320 ENOG41090PJ Flagellar assembly protein CEQ36_06325 ENOG4108JIR Flagellum-specific ATP synthase CEQ36_06330 ENOG4105GSA Flagellar export protein flij CEQ36_06335 ENOG4105WF4 Flagellar hook-length control protein CEQ36_06340 ENOG4107ZI8 flagellar basal body-associated protein flil CEQ36_06345 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CEQ36_06350 ENOG4105DD5 Flagellar motor switch protein CEQ36_06360 ENOG4105CN7 Flagellar biosynthetic protein FliP CEQ36_06365 ENOG4105VS8 Flagellar biosynthetic protein fliq CEQ36_06370 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CEQ36_06375 ENOG4105DTJ flagellar hook-associated protein CEQ36_06380 ENOG4105E1Q flagellar hook-associated protein CEQ36_06385 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CEQ36_06400 ENOG4105CGA flagellar basal-body rod protein FlgG CEQ36_06405 ENOG4108KPB Flagellar basal-body rod protein FlgF CEQ36_06410 ENOG4105BZE flagellar hook protein, FlgE CEQ36_06415 ENOG4105W00 Flagellar hook capping protein CEQ36_06420 ENOG4108ZC9 flagellar basal-body rod protein flgc CEQ36_06425 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CEQ36_06430 ENOG4105CKS Flagella basal body P-ring formation protein flgA CEQ36_06435 ENOG4105M9M anti-sigma28 factor FlgM CEQ36_06440 ENOG4105QVD Flagella synthesis protein FlgN CEQ36_06445 ENOG4105W13 flagellar protein CEQ36_06450 ENOG4105D7B Flagellar biosynthesis protein flha CEQ36_06455 ENOG4105D00 flagellar biosynthetic protein flhB CEQ36_06460 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) CEQ36_06465 ENOG4108VYJ response regulator receiver protein CEQ36_06475 ENOG4105BZU Histidine kinase CEQ36_06480 ENOG4105C8Q Methyl-accepting chemotaxis CEQ36_06490 ENOG4105C8Q Methyl-accepting chemotaxis CEQ36_06495 ENOG4108V3W Chemotaxis protein, CheW CEQ36_06500 ENOG4105CBS Chea signal transduction histidine kinase CEQ36_06505 ENOG4105ER2 Ompa motb domain protein CEQ36_06510 ENOG4107RD7 Flagellar Motor Protein, MotA CEQ36_06515 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region CEQ36_06520 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) CEQ36_06525 ENOG4108VA4 Universal stress protein CEQ36_06530 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CEQ36_06535 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CEQ36_06540 ENOG4105KT7 mgtC SapB transporter CEQ36_06545 ENOG4105C8Q Methyl-accepting chemotaxis CEQ36_06550 ENOG4105VZF DsrB protein CEQ36_06555 ENOG4105VEQ Cold shock protein CEQ36_06560 ENOG4105ETE Transcriptional regulator (LacI family CEQ36_06565 ENOG4105CNT hydrolase family 2 CEQ36_06580 ENOG4105GSJ Inner membrane protein ylaC CEQ36_06585 ENOG4105J0Q Transcriptional regulator CEQ36_06595 ENOG41061EV selenium-binding protein YdfZ CEQ36_06600 ENOG4105D6F Phosphatase CEQ36_06605 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CEQ36_06610 ENOG4108VEV chaperone CEQ36_06625 ENOG4108VEV chaperone CEQ36_06645 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) CEQ36_06660 ENOG4108UQ8 endoribonuclease L-psp CEQ36_06690 ENOG4105BZU Histidine kinase CEQ36_06695 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CEQ36_06700 ENOG4105ETE Transcriptional regulator (LacI family CEQ36_06710 ENOG4105CT4 transporter CEQ36_06715 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CEQ36_06720 ENOG4107QNK )-transporter CEQ36_06725 ENOG4108TSE Transferase CEQ36_06730 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CEQ36_06740 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CEQ36_06745 ENOG4107QPK )-transporter CEQ36_06750 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase CEQ36_06760 ENOG4105CHY citrate lyase, alpha CEQ36_06765 ENOG4105CI0 Citrate lyase CEQ36_06770 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) CEQ36_06775 ENOG4105DUA (citrate (pro-3S)-lyase ligase CEQ36_06780 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CEQ36_06785 ENOG4106YYS transcriptional regulatory protein CEQ36_06790 ENOG4108KX4 response regulator CEQ36_06795 ENOG4105BZU Histidine kinase CEQ36_06800 ENOG4105CXY transporter CEQ36_06805 ENOG4105C4Y ABC transporter CEQ36_06810 ENOG4107RCV ABC transporter, permease CEQ36_06815 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CEQ36_06825 ENOG4108Q9V regulatoR CEQ36_06830 ENOG4105BZU Histidine kinase CEQ36_06850 ENOG4105CW0 outer membrane usher protein CEQ36_06860 ENOG4108VCD Chaperone CEQ36_06975 ENOG4105NVB glycoside hydrolase, family 19 CEQ36_06980 ENOG4105CS6 Rhs element vgr protein CEQ36_06985 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CEQ36_06995 ENOG4105CDV Ompa motb domain protein CEQ36_07025 ENOG4105HEI LysR family (Transcriptional regulator CEQ36_07035 ENOG4105E98 transcriptional regulator DeoR family CEQ36_07040 ENOG410667J hydrolase CEQ36_07060 ENOG4107R88 Chemotaxis protein (CheV) CEQ36_07065 ENOG4105UQX Mate efflux family protein CEQ36_07070 ENOG4105CDH Citrulline--aspartate ligase CEQ36_07075 ENOG4105EAA nucleoside CEQ36_07080 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) CEQ36_07090 ENOG4105CN8 Transcriptional regulator CEQ36_07095 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CEQ36_07100 ENOG4108TGR phosphatase CEQ36_07105 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) CEQ36_07110 ENOG4108YZT Adenosylcobinamide kinase CEQ36_07115 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CEQ36_07125 ENOG4108V4M Cobalt abc transporter CEQ36_07130 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CEQ36_07135 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CEQ36_07140 ENOG4105DVK Precorrin-2 c20-methyltransferase CEQ36_07145 ENOG4107PPM cobalt chelatase CEQ36_07150 ENOG4105QUC reductase CEQ36_07155 ENOG4105E4R Precorrin-3B C17-methyltransferase CEQ36_07160 ENOG4108P62 biosynthesis protein (CbiG) CEQ36_07165 ENOG4105CIA precorrin-4 C(11)-methyltransferase CEQ36_07170 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase CEQ36_07175 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase CEQ36_07180 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) CEQ36_07185 ENOG41081F0 Precorrin-8x methylmutase CEQ36_07190 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CEQ36_07195 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CEQ36_07200 ENOG4107XVH Transcriptional regulator CEQ36_07205 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CEQ36_07210 ENOG4105KNY Microcompartments protein CEQ36_07215 ENOG4105EHR propanediol utilization protein pduB CEQ36_07220 ENOG4105DMB glycerol dehydratase CEQ36_07225 ENOG4105YCI dehydratase medium subunit CEQ36_07230 ENOG4108ZFT Dehydratase small subunit CEQ36_07235 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit CEQ36_07245 ENOG4105KNY Microcompartments protein CEQ36_07255 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) CEQ36_07265 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml CEQ36_07270 ENOG4108WBT adenosyltransferase CEQ36_07275 ENOG4108EKI Dehydrogenase CEQ36_07285 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CEQ36_07295 ENOG4105M3W utilization protein CEQ36_07300 ENOG4105KTW ethanolamine utilization protein CEQ36_07305 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CEQ36_07310 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CEQ36_07315 ENOG4107QZB decarboxylase CEQ36_07320 ENOG4105JZC GHMP kinase CEQ36_07325 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CEQ36_07330 ENOG4105C2J ABC transporter CEQ36_07335 ENOG4105CNN ABC, transporter CEQ36_07360 ENOG4105CJB Exodeoxyribonuclease I CEQ36_07365 ENOG4105CUB amino acid CEQ36_07375 ENOG4107SCQ Iron-containing alcohol dehydrogenase CEQ36_07380 ENOG4105C2J ABC transporter CEQ36_07385 ENOG4105CNN ABC, transporter CEQ36_07390 ENOG4108535 NAD dependent epimerase/dehydratase family CEQ36_07395 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CEQ36_07405 ENOG4105CIH Imidazole acetol-phosphate transaminase CEQ36_07410 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CEQ36_07415 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CEQ36_07425 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CEQ36_07430 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CEQ36_07440 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CEQ36_07445 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CEQ36_07450 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CEQ36_07455 ENOG4105EE5 Membrane protein terC CEQ36_07460 ENOG4105CEE C4-dicarboxylate transporter CEQ36_07465 ENOG4108GAE asmA family CEQ36_07475 ENOG4105DBI uridine monophosphokinase CEQ36_07480 ENOG4105D1F ATP-binding protein CEQ36_07485 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CEQ36_07505 ENOG4105E5W Transporter CEQ36_07510 ENOG4105VAW lrga family CEQ36_07515 ENOG41067MG lrgb family CEQ36_07525 ENOG4107R1I NAD-dependent malic enzyme CEQ36_07530 ENOG4107GZ4 SanA protein CEQ36_07545 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CEQ36_07550 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) CEQ36_07555 ENOG4108JPZ Monovalent cation H antiporter subunit D CEQ36_07560 ENOG4107TDF Formate hydrogenlyase subunit 4 CEQ36_07565 ENOG4105D65 subunit l CEQ36_07570 ENOG4107WQX hydrogenase 4 membrane subunit CEQ36_07575 ENOG4108JPZ Monovalent cation H antiporter subunit D CEQ36_07580 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEQ36_07590 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit CEQ36_07595 ENOG4105I6X formate hydrogenlyase maturation CEQ36_07600 ENOG4108MG9 hydrogenase 3 maturation protease CEQ36_07605 ENOG4108RC0 Electron transport protein CEQ36_07610 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CEQ36_07615 ENOG4108JUA Transcriptional regulator CEQ36_07620 ENOG4105TMB Formate nitrite transporter CEQ36_07625 ENOG4107SDZ Galactoside transport system permease protein mglC CEQ36_07640 ENOG41060NJ transcriptional regulator CEQ36_07645 ENOG4105DHF Membrane CEQ36_07650 ENOG4105EUJ GTP cyclohydrolase i CEQ36_07655 ENOG4105CBP Major Facilitator CEQ36_07660 ENOG4105EGI Transcriptional regulator CEQ36_07690 ENOG4105C19 ABC transporter CEQ36_07700 ENOG4105CSH Transporter CEQ36_07710 ENOG4105CVM Molybdenum cofactor synthesis domain protein CEQ36_07715 ENOG4105D06 uba thif-type nad fad binding protein CEQ36_07720 ENOG4105C5H ABC transporter CEQ36_07740 ENOG4108T1M outer membrane protein x CEQ36_07755 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) CEQ36_07765 ENOG4105KSC Transcriptional regulator, TraR DksA family CEQ36_07770 ENOG4107R0W ABC transporter CEQ36_07775 ENOG4105E5Q amino acid AbC transporter CEQ36_07780 ENOG4105CDA abc transporter atp-binding protein CEQ36_07785 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) CEQ36_07790 ENOG4108MTB glycosyl transferase family CEQ36_07795 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CEQ36_07800 ENOG4105DVT helicase CEQ36_07815 ENOG4105FDR Membrane CEQ36_07825 ENOG4105HEI LysR family (Transcriptional regulator CEQ36_07830 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CEQ36_07840 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component CEQ36_07845 ENOG4108IJ8 ABC transporter CEQ36_07850 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component CEQ36_07855 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system CEQ36_07865 ENOG4107RJ5 oxidoreductase CEQ36_07870 ENOG4105KHC sulfurtransferase CEQ36_07875 ENOG4108IV0 ABC, transporter CEQ36_07880 ENOG4105C0Z ABC transporter CEQ36_07885 ENOG4105CNN ABC, transporter CEQ36_07890 ENOG4105C32 Amino acid ABC transporter (Permease) CEQ36_07895 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein CEQ36_07900 ENOG4108W15 Protein of unknown function (DUF1456) CEQ36_07915 ENOG4105EHI Phosphonate ABC transporter, periplasmic CEQ36_07925 ENOG4105Y3U Transglycosylase-associated protein CEQ36_07935 ENOG4105N1F Hnh endonuclease CEQ36_07945 ENOG4105CXG d-lactate dehydrogenase CEQ36_07950 ENOG41061WM D-Alanyl-D-Alanine CEQ36_07960 ENOG4105CJW magnesium transporter CEQ36_07965 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) CEQ36_07970 ENOG4105C1J atp-dependent rna helicase CEQ36_07975 ENOG4107MVR Transcriptional regulator CEQ36_07980 ENOG4105D0S secretion protein (HlyD CEQ36_07985 ENOG4105CJ1 ABC, transporter CEQ36_07990 ENOG4107QWP ABC-2 type transporter CEQ36_07995 ENOG4107QWP ABC-2 type transporter CEQ36_08000 ENOG4105HFZ Membrane CEQ36_08005 ENOG4108ZAF Molybdopterin CEQ36_08010 ENOG4105M00 molybdopterin converting factor, subunit 1 CEQ36_08015 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CEQ36_08020 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CEQ36_08025 ENOG4105CHW UPF0052 protein CEQ36_08030 ENOG4105VYA Uncharacterized conserved protein (DUF2132) CEQ36_08035 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CEQ36_08045 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CEQ36_08050 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CEQ36_08060 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CEQ36_08070 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CEQ36_08075 ENOG4108K4B hydrolase CEQ36_08085 ENOG4105E0C molybdate abc transporter CEQ36_08090 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CEQ36_08095 ENOG410680R Protein of unknown function (DUF2592) CEQ36_08100 ENOG4105F4R Transcriptional regulator mode CEQ36_08105 ENOG4105DKW ABC transporter CEQ36_08120 ENOG4105CMR udp-glucose 4-epimerase CEQ36_08125 ENOG4105F0Z galactose-1-phosphate uridylyltransferase CEQ36_08130 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CEQ36_08135 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CEQ36_08140 ENOG4105VIF phosphate starvation-inducible protein CEQ36_08145 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CEQ36_08150 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CEQ36_08155 ENOG4105WH1 Two component transcriptional regulator luxr family CEQ36_08160 ENOG4105BZU Histidine kinase CEQ36_08165 ENOG4105PGM cation diffusion facilitator family transporter CEQ36_08170 ENOG4106Z1T Nicotinamide Mononucleotide Transporter CEQ36_08175 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CEQ36_08205 ENOG4105UFD tol-pal system protein YbgF CEQ36_08210 ENOG4105KCK Peptidoglycan-associated lipoprotein CEQ36_08215 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) CEQ36_08220 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA CEQ36_08220 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA CEQ36_08225 ENOG4105M8F Biopolymer transport protein exbD tolR CEQ36_08230 ENOG4105E02 MotA TolQ exbB proton channel CEQ36_08235 ENOG4107YD3 Thioesterase CEQ36_08240 ENOG4105KJB cyd operon protein YbgE CEQ36_08250 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CEQ36_08255 ENOG4105C4M (Ubiquinol oxidase) subunit I CEQ36_08260 ENOG4105CGH 5'-nucleotidase CEQ36_08265 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CEQ36_08270 ENOG4105CMV Succinyl-CoA synthetase subunit beta CEQ36_08275 ENOG4105C7S Dehydrogenase CEQ36_08280 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CEQ36_08285 ENOG4105E33 succinate dehydrogenase CEQ36_08295 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein CEQ36_08300 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit CEQ36_08305 ENOG4105BZN citrate synthase CEQ36_08325 ENOG4105E7W lamb ycsf family protein CEQ36_08330 ENOG4107R7A Allophanate hydrolase subunit 2 CEQ36_08335 ENOG4105P4J Allophanate hydrolase, subunit 1 CEQ36_08340 ENOG4107QNR UPF0135 protein CEQ36_08345 ENOG4107RF4 Phosphodiesterase CEQ36_08350 ENOG4105CVP deoxyribo-dipyrimidine photolyase CEQ36_08355 ENOG4107SEY Conserved Protein CEQ36_08360 ENOG4105XIQ Protein of unknown function (DUF2517) CEQ36_08375 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CEQ36_08380 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CEQ36_08385 ENOG4105C08 Histidine kinase CEQ36_08390 ENOG4105EEX Two component transcriptional regulator (Winged helix family CEQ36_08400 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 CEQ36_08490 ENOG4105EV9 Alpha Beta Hydrolase CEQ36_08500 ENOG4105NNH LexA regulated protein CEQ36_08505 ENOG4105C8Q Methyl-accepting chemotaxis CEQ36_08510 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) CEQ36_08515 ENOG41090R7 Ferric uptake CEQ36_08525 ENOG4105GX6 (LipO)protein CEQ36_08530 ENOG4105J5J Outer membrane porin CEQ36_08535 ENOG4105CX6 glutaminyL-tRNA synthetase CEQ36_08540 ENOG4105CI1 PTS System CEQ36_08545 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CEQ36_08550 ENOG4105CE4 GlcNAc 6-P deacetylase CEQ36_08555 ENOG4105E2R ROK family CEQ36_08560 ENOG4105D4U had-superfamily hydrolase, subfamily iia CEQ36_08570 ENOG4105CAQ asparagine synthetase CEQ36_08615 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CEQ36_08620 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CEQ36_08625 ENOG4105C9A Phoh family CEQ36_08630 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CEQ36_08635 ENOG4108JU5 Magnesium and cobalt efflux protein CEQ36_08640 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CEQ36_08650 ENOG4107RP9 extracellular solute-binding protein, family 3 CEQ36_08655 ENOG4105EAD ABC transporter CEQ36_08660 ENOG4105DRP amino acid AbC transporter CEQ36_08665 ENOG4105CDA abc transporter atp-binding protein CEQ36_08675 ENOG4107PAI alpha helical protein CEQ36_08680 ENOG4105C8T Leucyl-tRNA synthetase CEQ36_08685 ENOG4108U2H Rare lipoprotein B CEQ36_08690 ENOG4105DJF DNA polymerase III, delta' subunit CEQ36_08695 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CEQ36_08700 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) CEQ36_08710 ENOG4105CJN penicillin-binding protein CEQ36_08715 ENOG4105CNI cell division protein FtsW CEQ36_08720 ENOG4105K6T rare lipoprotein A CEQ36_08725 ENOG4105DZ1 carboxypeptidase CEQ36_08730 ENOG4108Z43 UPF0250 protein CEQ36_08735 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CEQ36_08740 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CEQ36_08745 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) CEQ36_08750 ENOG4105BZU Histidine kinase CEQ36_08755 ENOG4107Z6W Protein CrcB homolog CEQ36_08760 ENOG4105VEQ Cold shock protein CEQ36_08770 ENOG4108N8T regulatoR CEQ36_08780 ENOG4108R1E Serine threonine protein phosphatase 1 CEQ36_08800 ENOG4108JJ7 ABC transporter CEQ36_08805 ENOG4105EZE Cupin 4 family protein CEQ36_08820 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CEQ36_08825 ENOG4108YZG isomerase CEQ36_08830 ENOG4105NYY transcriptional regulator, RpiR CEQ36_08835 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CEQ36_08840 ENOG4105C2J ABC transporter CEQ36_08845 ENOG4105CNN ABC, transporter CEQ36_08850 ENOG4105UP7 3-epimerase CEQ36_08855 ENOG4107TFG D-allose kinase CEQ36_08865 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) CEQ36_08870 ENOG4107EFN gluconate transport system permease 3 CEQ36_08880 ENOG4105E1F short-chain dehydrogenase reductase CEQ36_08890 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CEQ36_08910 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CEQ36_08925 ENOG4105BZS acriflavin resistance protein CEQ36_08935 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CEQ36_08940 ENOG4105CC0 LysR family Transcriptional regulator CEQ36_08945 ENOG4105CY0 Metallo-Beta-Lactamase CEQ36_08960 ENOG4105ETT transcriptional Regulator, LysR family CEQ36_09015 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme CEQ36_09030 ENOG4105D3G Pseudouridine synthase CEQ36_09100 ENOG4105KUU lipolytic protein G-D-S-L family CEQ36_09110 ENOG4108K2B transcriptional regulator CEQ36_09115 ENOG4105F8D glycoside hydrolase family 4 CEQ36_09120 ENOG4105CT4 transporter CEQ36_09130 ENOG4105G0K glycine radical enzyme YjjI family CEQ36_09135 ENOG41076CZ activating enzyme CEQ36_09150 ENOG4108KU3 Integrase CEQ36_09195 ENOG4105RFR Protein of unknown function (DUF2767) CEQ36_09200 ENOG4105UZW Tail fiber assembly protein CEQ36_09260 ENOG4105TKZ Tail Sheath CEQ36_09375 ENOG4105HRS Antitermination protein CEQ36_09440 ENOG4105DFP Integrase CEQ36_09445 ENOG4105EXC Acyl-transferase CEQ36_09555 ENOG4108N0N Phage Terminase Large Subunit CEQ36_09580 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 CEQ36_09595 ENOG4105HGD Antitermination protein CEQ36_09605 ENOG4105RWQ Protein of unknown function (DUF1364) CEQ36_09610 ENOG4105MEW serine threonine protein phosphatase CEQ36_09650 ENOG4105CDU Replicative dna helicase CEQ36_09770 ENOG4108KU3 Integrase CEQ36_09780 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CEQ36_09785 ENOG4105WQ3 Rna-binding protein CEQ36_09790 ENOG4105C8N cysteinyl-tRNA synthetase CEQ36_09795 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CEQ36_09800 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) CEQ36_09805 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CEQ36_09810 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CEQ36_09815 ENOG4105CV6 ABC transporter, permease CEQ36_09820 ENOG4108I0Y (ABC) transporter CEQ36_09825 ENOG4108UJV acyl-CoA thioesterase i CEQ36_09830 ENOG4105E1F short-chain dehydrogenase reductase CEQ36_09835 ENOG4107QR8 Thioredoxin CEQ36_09840 ENOG4107QX8 SPFH domain, Band 7 family protein CEQ36_09845 ENOG4105G5H Membrane CEQ36_09850 ENOG4108Z6Z Transcriptional regulator CEQ36_09855 ENOG4105C59 p-type ATPase CEQ36_09860 ENOG4105MBR gumn family CEQ36_09865 ENOG4108Z66 YbaK ebsC protein CEQ36_09870 ENOG4105CGH 5'-nucleotidase CEQ36_09875 ENOG4105EU0 Major facilitator Superfamily CEQ36_09880 ENOG4105CKD glutathione-regulated potassium-efflux system protein CEQ36_09885 ENOG4107RE1 Inosine-guanosine kinase CEQ36_09890 ENOG4108QY5 Ferric enterobactin transport protein CEQ36_09895 ENOG4105CMR udp-glucose 4-epimerase CEQ36_09900 ENOG4107QKV phosphomannomutase CEQ36_09905 ENOG4105CJT Mannose-1-phosphate guanylyltransferase CEQ36_09910 ENOG4105C30 Nad-dependent epimerase dehydratase CEQ36_09915 ENOG4105C0K Gdp-mannose 4,6-dehydratase CEQ36_09920 ENOG4108KMV Glycosyl transferase (Group 1 CEQ36_09930 ENOG4107S6X Glycosyl transferase, family 2 CEQ36_09945 ENOG4107YYJ Glycosyl transferase, family 2 CEQ36_09960 ENOG4105C7K acetolactate synthase CEQ36_09965 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CEQ36_09970 ENOG4105FAW cDP-glucose 4,6-dehydratase CEQ36_09975 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CEQ36_09980 ENOG4108EX3 reductase CEQ36_09985 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CEQ36_09990 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CEQ36_09995 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CEQ36_10000 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CEQ36_10005 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CEQ36_10010 ENOG4107QMP dna polymerase iii subunits gamma and tau CEQ36_10015 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase CEQ36_10025 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CEQ36_10030 ENOG4105WD1 Membrane CEQ36_10040 ENOG4106428 Protein of unknown function (DUF2496) CEQ36_10045 ENOG4105EGS Mechanosensitive ion channel CEQ36_10050 ENOG41090EX DsrE family CEQ36_10055 ENOG4108IG5 Transcriptional regulator CEQ36_10060 ENOG4105C1P efflux transporter, rnd family, mfp subunit CEQ36_10065 ENOG4105BZS acriflavin resistance protein CEQ36_10070 ENOG4105NRA 50s ribosomal protein l31 type b CEQ36_10075 ENOG4105YK5 50S ribosomal protein L36 CEQ36_10080 ENOG4105DSE periplasmic solute binding protein CEQ36_10085 ENOG4105CC5 ABC transporter CEQ36_10090 ENOG4105DIK (ABC) transporter CEQ36_10100 ENOG4108UKR Biofilm formation regulator YbaJ CEQ36_10105 ENOG4105KF5 hemolysin expression-modulating protein CEQ36_10115 ENOG41080UX Methyltransferase CEQ36_10120 ENOG4108MNP Glycoprotein polysaccharide metabolism CEQ36_10125 ENOG4105C29 acyl-CoA thioesterase CEQ36_10130 ENOG4105BZU Histidine kinase CEQ36_10135 ENOG4108YZA Nitrogen regulatory protein pii CEQ36_10140 ENOG4105BZ1 (ABC) transporter CEQ36_10145 ENOG4105BZ1 (ABC) transporter CEQ36_10150 ENOG4108XM1 transcriptional regulator AsnC family CEQ36_10160 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) CEQ36_10165 ENOG4108NFA extracellular solute-binding protein CEQ36_10170 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CEQ36_10175 ENOG4108TGP Thioesterase superfamily protein CEQ36_10180 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein CEQ36_10185 ENOG4105EIN peptidylprolyl cis-trans isomerase CEQ36_10190 ENOG4105K70 DNA-binding protein CEQ36_10195 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CEQ36_10200 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CEQ36_10205 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CEQ36_10220 ENOG4105M85 Bola protein CEQ36_10225 ENOG4105IEY (LipO)protein CEQ36_10230 ENOG4105EYM Major Facilitator superfamily CEQ36_10235 ENOG4108NFH Sugar hydrolase CEQ36_10240 ENOG4105E2S oxidase) subunit II CEQ36_10245 ENOG4105BZ9 Cytochrome C oxidase, subunit I CEQ36_10250 ENOG4105CCU oxidase (Subunit III) CEQ36_10255 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) CEQ36_10260 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CEQ36_10265 ENOG4107RDB Major Facilitator CEQ36_10270 ENOG4108VPT UPF0234 protein CEQ36_10280 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CEQ36_10285 ENOG4107S0N DJ-1 family CEQ36_10295 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CEQ36_10305 ENOG4105CTB Polyprenyl synthetase CEQ36_10310 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CEQ36_10320 ENOG4108ZAI phosphatidylglycerophosphatase a CEQ36_10325 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CEQ36_10335 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CEQ36_10340 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CEQ36_10345 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CEQ36_10355 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CEQ36_10360 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CEQ36_10365 ENOG4105VIE preprotein translocase, subunit YajC CEQ36_10375 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CEQ36_10380 ENOG4108ZYK Acyl carrier protein phosphodiesterase CEQ36_10385 ENOG4105D3R alkyl hydroperoxide reductase CEQ36_10395 ENOG4105CHR reductase CEQ36_10400 ENOG4107R28 alpha amylase, catalytic region CEQ36_10405 ENOG4105C85 amino acid CEQ36_10410 ENOG4105CWM branched-chain amino acid transport system II carrier protein CEQ36_10420 ENOG4105BZU Histidine kinase CEQ36_10425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEQ36_10430 ENOG4107RH8 nuclease SbcCD subunit D CEQ36_10435 ENOG4105EYH Exonuclease CEQ36_10440 ENOG4105DKQ ROK family CEQ36_10445 ENOG4105DH7 May be involved in recombination (By similarity) CEQ36_10450 ENOG4105NBK UPF0345 protein CEQ36_10455 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CEQ36_10475 ENOG4105F2W methyltransferase CEQ36_10490 ENOG4105E2V Glycosyltransferase 36 CEQ36_10500 ENOG4105D9N nucleoside CEQ36_10505 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) CEQ36_10510 ENOG4105DD7 kinase (PfkB family CEQ36_10515 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CEQ36_10520 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CEQ36_10525 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) CEQ36_10530 ENOG4105V1F Fermentation respiration switch protein CEQ36_10540 ENOG4105CIN aminoacyl-histidine dipeptidase CEQ36_10545 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CEQ36_10550 ENOG4105CPF Cell wall formation (By similarity) CEQ36_10565 ENOG4105CJ2 (LipO)protein CEQ36_10570 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) CEQ36_10575 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CEQ36_10580 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CEQ36_10585 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CEQ36_10590 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CEQ36_10595 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CEQ36_10600 ENOG4105F7V ErfK ybiS ycfS ynhG family protein CEQ36_10605 ENOG4105E7A Glutamine amidotransferase CEQ36_10610 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CEQ36_10615 ENOG4107QPN acyl-Coa dehydrogenase CEQ36_10620 ENOG4106YJS accessory processing protein CEQ36_10640 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CEQ36_10650 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CEQ36_10660 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CEQ36_10665 ENOG4105CHM Aminotransferase CEQ36_10680 ENOG4105C5R Aminotransferase CEQ36_10690 ENOG4105EQ0 Major Facilitator superfamily CEQ36_10695 ENOG4108UMN azlc family CEQ36_10700 ENOG4105ZED uncharacterized protein ygaH CEQ36_10705 ENOG4105NTK Transcriptional repressor Mpra CEQ36_10720 ENOG4105CW7 secretion protein, HlyD family CEQ36_10725 ENOG4105C0R drug resistance transporter emrb qaca subfamily CEQ36_10730 ENOG4105EIB trna rrna methyltransferase CEQ36_10735 ENOG4105K63 Thioredoxin CEQ36_10740 ENOG4106IUH DTW domain containing protein CEQ36_10745 ENOG4105CD5 CoA-binding domain protein CEQ36_10750 ENOG4105JIM Phosphatidylserine synthase CEQ36_10755 ENOG4105T42 (LipO)protein CEQ36_10790 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CEQ36_10800 ENOG4108UMI ABC transporter, permease CEQ36_10805 ENOG4105D01 (LipO)protein CEQ36_10810 ENOG4108R8X outer membrane lipoprotein CEQ36_10815 ENOG4108R96 Methyltransferase, YaeB family CEQ36_10820 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CEQ36_10825 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion CEQ36_10830 ENOG4108YZN class I peptide chain release factor CEQ36_10835 ENOG4108VWS Yaeq family CEQ36_10845 ENOG4105M1T rho-binding antiterminator CEQ36_10850 ENOG4105N7H Cytochrome CEQ36_10855 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CEQ36_10860 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CEQ36_10865 ENOG4105CXN decarboxylase CEQ36_10870 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CEQ36_10875 ENOG4105C0B DNA polymerase III (alpha subunit) CEQ36_10880 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CEQ36_10885 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CEQ36_10890 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CEQ36_10895 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CEQ36_10905 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) CEQ36_10915 ENOG4105DZP Membrane-associated zinc metalloprotease CEQ36_10920 ENOG4105KNE Phosphatidate cytidylyltransferase CEQ36_10925 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CEQ36_10930 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CEQ36_10935 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CEQ36_10940 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CEQ36_10945 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CEQ36_10950 ENOG4105CE9 30S ribosomal protein S2 CEQ36_10955 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CEQ36_10960 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) CEQ36_10965 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) CEQ36_10970 ENOG4108T8E UPF0325 protein CEQ36_10975 ENOG4105QDK Flavodoxin CEQ36_10980 ENOG4105DR9 pseudouridine synthase CEQ36_10985 ENOG4105WP7 tRNA pseudouridine synthase C CEQ36_10990 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) CEQ36_10995 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CEQ36_11000 ENOG4105EWT decarboxylase family CEQ36_11005 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease CEQ36_11010 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) CEQ36_11015 ENOG4105M08 Membrane CEQ36_11020 ENOG4105ETT transcriptional Regulator, LysR family CEQ36_11025 ENOG4105M5B (LipO)protein CEQ36_11030 ENOG4105C9B Cysteine desulfurase CEQ36_11035 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CEQ36_11040 ENOG4105CUZ uba thif-type nad fad binding protein CEQ36_11045 ENOG4105CA3 membrane-bound lytic murein transglycosylase CEQ36_11065 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CEQ36_11070 ENOG4107QZM n-acetylglutamate synthase CEQ36_11075 ENOG4107QYX exodeoxyribonuclease v alpha CEQ36_11080 ENOG4107QKA exodeoxyribonuclease V beta CEQ36_11085 ENOG4107QXK peptidase CEQ36_11090 ENOG4105DSY exodeoxyribonuclease V, gamma CEQ36_11105 ENOG4105JCS prepilin peptidase dependent protein CEQ36_11110 ENOG4105IPU prepilin peptidase dependent protein A CEQ36_11120 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CEQ36_11125 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase CEQ36_11140 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) CEQ36_11145 ENOG4105EE5 Membrane protein terC CEQ36_11155 ENOG4105CPC Aldo Keto reductase CEQ36_11160 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) CEQ36_11165 ENOG4105CEY Amp-dependent synthetase and ligase CEQ36_11175 ENOG41060NJ transcriptional regulator CEQ36_11185 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CEQ36_11190 ENOG4105RQF LysR family Transcriptional regulator CEQ36_11195 ENOG4105EJC lysr family transcriptional regulator CEQ36_11210 ENOG4105C8Q Methyl-accepting chemotaxis CEQ36_11260 ENOG4108VAU general secretion pathway protein G CEQ36_11265 ENOG4105D7Q type ii secretion system CEQ36_11270 ENOG4107QHF type ii secretion system protein e CEQ36_11290 ENOG4107B2H carbonic anhydrase CEQ36_11295 ENOG4105KVH Transcriptional regulator CEQ36_11300 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CEQ36_11315 ENOG4105DVC DnaJ domain protein CEQ36_11325 ENOG4105DPW Major facilitator superfamily MFS_1 CEQ36_11340 ENOG4105F7P transcriptional regulator AsnC family CEQ36_11345 ENOG4105BZU Histidine kinase CEQ36_11375 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CEQ36_11380 ENOG4105T95 Thiol disulfide interChange protein CEQ36_11385 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CEQ36_11390 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) CEQ36_11395 ENOG4105CT7 inner membrane cred family protein CEQ36_11400 ENOG4105EB3 Histidine kinase CEQ36_11405 ENOG4105E3W Two component transcriptional regulator (Winged helix family CEQ36_11415 ENOG4105Y75 tpr repeat protein CEQ36_11420 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CEQ36_11425 ENOG4108UT2 hemolysin iii CEQ36_11435 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CEQ36_11440 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CEQ36_11445 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CEQ36_11450 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CEQ36_11455 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CEQ36_11460 ENOG4105D0A hydroxylase CEQ36_11465 ENOG4107RAQ aminopeptidase CEQ36_11470 ENOG4105E07 UPF0149 protein CEQ36_11480 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CEQ36_11490 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CEQ36_11495 ENOG4108JQ1 Dehydrogenase CEQ36_11500 ENOG4105E66 phosphoriboisomerase A CEQ36_11505 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CEQ36_11510 ENOG4105MPN Membrane CEQ36_11515 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CEQ36_11520 ENOG4105D64 Mechanosensitive ion channel CEQ36_11525 ENOG4105D2N Aldolase CEQ36_11530 ENOG4105BZA Phosphoglycerate kinase CEQ36_11535 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CEQ36_11540 ENOG4105CV1 Transketolase (EC 2.2.1.1) CEQ36_11545 ENOG4108K0D peptidase, M48 CEQ36_11555 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) CEQ36_11565 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CEQ36_11580 ENOG41080HT Transcriptional regulator, arsr family CEQ36_11585 ENOG4105GPY SprT protein CEQ36_11590 ENOG4105RWS endonuclease I CEQ36_11595 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CEQ36_11600 ENOG4105D7Z glutathione synthase CEQ36_11605 ENOG4108UJU UPF0301 protein CEQ36_11610 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CEQ36_11615 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) CEQ36_11625 ENOG4105CZX twitching motility protein CEQ36_11630 ENOG4105DFA alanine racemase domain protein CEQ36_11635 ENOG4105II7 pyrroline-5-carboxylate reductase CEQ36_11640 ENOG4108VIA integral membrane protein CEQ36_11645 ENOG4105VZ9 UPF0235 protein CEQ36_11650 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CEQ36_11655 ENOG4105CSA Coproporphyrinogen iii oxidase CEQ36_11660 ENOG4105K33 Periplasmic Protein CEQ36_11665 ENOG4105CSV Glutaminase CEQ36_11670 ENOG41090ED Protein with unknown function (DUF469) CEQ36_11675 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CEQ36_11680 ENOG4105CEN a g-specific adenine glycosylase CEQ36_11690 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division CEQ36_11700 ENOG4105CXN decarboxylase CEQ36_11725 ENOG4107B2H carbonic anhydrase CEQ36_11740 ENOG4105BZU Histidine kinase CEQ36_11745 ENOG4108WQH regulatoR CEQ36_11750 ENOG4105PFC Transcriptional regulator CEQ36_11780 ENOG4105CS6 Rhs element vgr protein CEQ36_11825 ENOG4105CW0 outer membrane usher protein CEQ36_11830 ENOG4108VEV chaperone CEQ36_11840 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CEQ36_11890 ENOG4108N8T regulatoR CEQ36_11910 ENOG4106NDP Transcriptional regulator CEQ36_11920 ENOG4108HKT sucrose-6-phosphate hydrolase CEQ36_11940 ENOG4105D7K pfkb domain protein CEQ36_11945 ENOG4108K3Z AraC family transcriptional regulator CEQ36_11955 ENOG4108X49 Ethanolamine utilization protein EutK CEQ36_11960 ENOG4106D67 ethanolamine utilization protein CEQ36_11970 ENOG4105CPD ethanolamine ammonia-lyase CEQ36_11975 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase CEQ36_11980 ENOG4105ENY Ethanolamine utilization protein eutH CEQ36_11985 ENOG4105C0A alcohol dehydrogenase CEQ36_11990 ENOG4107RWI ethanolamine utilization protein eutJ CEQ36_11995 ENOG4108EKI Dehydrogenase CEQ36_12000 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml CEQ36_12005 ENOG4105KNY Microcompartments protein CEQ36_12010 ENOG4108IJ2 phosphate acetyltransferase CEQ36_12015 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase CEQ36_12020 ENOG4105NDK ethanolamine utilization protein CEQ36_12025 ENOG4106S4J ethanolamine utilization protein EutP CEQ36_12030 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place CEQ36_12045 ENOG4105FDP GntR family transcriptional regulator CEQ36_12050 ENOG4105CI1 PTS System CEQ36_12055 ENOG4105F8D glycoside hydrolase family 4 CEQ36_12065 ENOG4105CI1 PTS System CEQ36_12070 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) CEQ36_12085 ENOG4108V1T peptidylprolyl cis-trans isomerase CEQ36_12090 ENOG4105DE4 1-phosphofructokinase CEQ36_12095 ENOG4105BZU Histidine kinase CEQ36_12110 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CEQ36_12125 ENOG4105E1F short-chain dehydrogenase reductase CEQ36_12135 ENOG4108XDN Transcriptional regulator CEQ36_12140 ENOG4108VKM cytochrome b561 CEQ36_12175 ENOG4105PGM cation diffusion facilitator family transporter CEQ36_12180 ENOG4108IQI permease CEQ36_12185 ENOG4107QK5 Homocysteine s-methyltransferase CEQ36_12190 ENOG4105E8G Major facilitator Superfamily CEQ36_12300 ENOG4105CW0 outer membrane usher protein CEQ36_12305 ENOG4105CW0 outer membrane usher protein CEQ36_12310 ENOG4108NAE Fimbrial chaperone protein CEQ36_12315 ENOG4108VCD Chaperone CEQ36_12325 ENOG4108UIF Chaperone CEQ36_12350 ENOG4108MI0 Resistance protein CEQ36_12355 ENOG4105J12 Multidrug resistance protein mdtN CEQ36_12395 ENOG4105DUU IucA IucC family protein CEQ36_12410 ENOG4108IPW abc transporter atp-binding protein CEQ36_12415 ENOG4105CM4 permease protein CEQ36_12430 ENOG4105EAM Na Pi-cotransporter CEQ36_12435 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CEQ36_12440 ENOG4105CFC Transporter CEQ36_12450 ENOG4105BZU Histidine kinase CEQ36_12465 ENOG4105CSH Transporter CEQ36_12470 ENOG4107FQ9 ethanolamine ammonia-lyase CEQ36_12475 ENOG4105CPD ethanolamine ammonia-lyase CEQ36_12480 ENOG4105C85 amino acid CEQ36_12490 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase CEQ36_12495 ENOG4105C8H hydrogenase maturation protein Hypf CEQ36_12500 ENOG4105C45 hydrogenase expression formation protein (HypE) CEQ36_12505 ENOG4105CQS hydrogenase expression formation protein HypD CEQ36_12510 ENOG41082MF Hydrogenase assembly chaperone hypC hupF CEQ36_12515 ENOG4107RSS Hydrogenase accessory protein HypB CEQ36_12520 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CEQ36_12525 ENOG4108WGS hydrogenase 2-specific chaperone CEQ36_12530 ENOG4108USZ hydrogenase CEQ36_12535 ENOG4105DPX Hydrogenase, large subunit CEQ36_12540 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit CEQ36_12545 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CEQ36_12550 ENOG4105E3S small subunit CEQ36_12555 ENOG4108XTF Outer Membrane Lipoprotein CEQ36_12575 ENOG4105C8Q Methyl-accepting chemotaxis CEQ36_12580 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein CEQ36_12585 ENOG4105DQ5 transport system permease protein CEQ36_12590 ENOG4105TVJ transport system, permease CEQ36_12595 ENOG4105E0A ABC, transporter CEQ36_12620 ENOG4105EP1 Efflux transporter rnd family, mfp subunit CEQ36_12625 ENOG4108IJF Heavy metal efflux pump, CzcA CEQ36_12630 ENOG4105CF1 Alkylated DNA repair protein CEQ36_12705 ENOG4108ZZF transport protein (ExbD) CEQ36_12710 ENOG4105CWK Biopolymer transport protein, ExbB CEQ36_12715 ENOG4105C28 cystathionine CEQ36_12720 ENOG4108K81 inner membrane protein YghB CEQ36_12725 ENOG4105CF7 AraC family transcriptional regulator CEQ36_12730 ENOG4108I6A alcohol dehydrogenase CEQ36_12735 ENOG4105CV8 reductase CEQ36_12755 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) CEQ36_12760 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase CEQ36_12765 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CEQ36_12775 ENOG4108UZY PTS System CEQ36_12780 ENOG4105ETZ PTS System CEQ36_12785 ENOG4105F3R pts system mannose fructose sorbose family iid CEQ36_12800 ENOG4107S5I aldo keto reductase CEQ36_12805 ENOG4108JP0 extracellular solute-binding protein family 1 CEQ36_12810 ENOG4105E0F Histidine kinase CEQ36_12815 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CEQ36_12820 ENOG4105NF4 modulator of drug activity CEQ36_12825 ENOG4105VRH Antibiotic biosynthesis monooxygenase CEQ36_12835 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CEQ36_12840 ENOG4105IPS esterase CEQ36_12845 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CEQ36_12850 ENOG4108SX3 cytoplasmic protein CEQ36_12855 ENOG41087AY ADP-Ribose pyrophosphatase CEQ36_12860 ENOG4105DFG type I secretion outer membrane protein CEQ36_12865 ENOG4105F1G UPF0441 protein CEQ36_12870 ENOG4106032 Glutathionylspermidine synthase CEQ36_12875 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CEQ36_12880 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CEQ36_12885 ENOG4105W0Z cytoplasmic protein CEQ36_12890 ENOG4105DVH amino acid CEQ36_12895 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CEQ36_12900 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CEQ36_12905 ENOG4105I7R Adenylate cyclase CEQ36_12910 ENOG4106MWK domain protein CEQ36_12915 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CEQ36_12925 ENOG4107ZVW dihydroneopterin aldolase CEQ36_12930 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CEQ36_12935 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CEQ36_12940 ENOG4105VCC 30S ribosomal protein S21 CEQ36_12945 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CEQ36_12950 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CEQ36_12965 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures CEQ36_12970 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles CEQ36_12975 ENOG4108XS9 dna repair protein CEQ36_12980 ENOG4106H6R UPF0380 protein CEQ36_12995 ENOG4108KZE transcriptional regulator CEQ36_13000 ENOG4108MXD gtp-binding protein CEQ36_13040 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CEQ36_13050 ENOG4105CPF Cell wall formation (By similarity) CEQ36_13070 ENOG4108594 Permease of the drug metabolite transporter CEQ36_13110 ENOG4108W76 histidinol phosphate phosphatase hisj family CEQ36_13150 ENOG4105T40 surface antigen msp4 family protein CEQ36_13160 ENOG4108MGN ATP-binding component of a transport system CEQ36_13165 ENOG4105D5K Hemolysin activator protein CEQ36_13185 ENOG4105JXR Protein of unknown function (DUF3296) CEQ36_13190 ENOG4108P8R CEQ36_13210 ENOG4105MZU cell filamentation protein CEQ36_13280 ENOG4108594 Permease of the drug metabolite transporter CEQ36_13285 ENOG4105D29 Helix-turn-helix type 11 domain protein CEQ36_13295 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CEQ36_13300 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) CEQ36_13305 ENOG4108P8G outer membrane autotransporter barrel CEQ36_13310 ENOG4108VKG metal-dependent hydrolase CEQ36_13315 ENOG4105EE0 oxidoreductase CEQ36_13320 ENOG4105DU1 integral membrane protein, terc CEQ36_13325 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) CEQ36_13330 ENOG4105P66 Membrane CEQ36_13335 ENOG4105CTX dehydratase CEQ36_13340 ENOG4107QZW Altronate oxidoreductase CEQ36_13350 ENOG4105DPW Major facilitator superfamily MFS_1 CEQ36_13365 ENOG4106W5V Membrane CEQ36_13380 ENOG4105NE1 Conserved Protein CEQ36_13385 ENOG41090KG Inner membrane protein YqjE CEQ36_13390 ENOG4105YJD CEQ36_13395 ENOG4108VBZ doxx family CEQ36_13400 ENOG4105CHF Glutathione S-transferase CEQ36_13405 ENOG4105CWB LysR family transcriptional Regulator CEQ36_13410 ENOG4108CNN domain protein CEQ36_13415 ENOG4105DQ4 alcohol dehydrogenase CEQ36_13430 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CEQ36_13445 ENOG41082RQ UPF0102 protein CEQ36_13450 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CEQ36_13455 ENOG4105W4M Transport-associated protein CEQ36_13460 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase CEQ36_13465 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain CEQ36_13475 ENOG4105BZU Histidine kinase CEQ36_13480 ENOG4105N5T Radical SAM Protein CEQ36_13485 ENOG4105CBC glutamate synthase CEQ36_13490 ENOG4105BZ8 glutamate synthase CEQ36_13500 ENOG4105KB2 stringent starvation protein b CEQ36_13505 ENOG4107MKT Stringent starvation protein a CEQ36_13515 ENOG4108UJD 30S ribosomal protein S9 CEQ36_13520 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CEQ36_13525 ENOG4105D6Z AFG1 family ATPase CEQ36_13530 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III CEQ36_13535 ENOG4105C0H protease CEQ36_13540 ENOG4105C0H protease CEQ36_13545 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CEQ36_13550 ENOG4105VFK BolA family CEQ36_13555 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane CEQ36_13560 ENOG4105E3I toluene tolerance CEQ36_13565 ENOG4107PE3 Mammalian cell entry related domain protein CEQ36_13570 ENOG4105CY3 ABC transporter, permease CEQ36_13575 ENOG4105DHJ ABC, transporter CEQ36_13580 ENOG4105FEU K -dependent Na -Ca exchanger CEQ36_13585 ENOG4105C2X Arabinose 5-phosphate isomerase CEQ36_13590 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase CEQ36_13595 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) CEQ36_13600 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA CEQ36_13605 ENOG4108IUZ ABC transporter CEQ36_13610 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CEQ36_13615 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA CEQ36_13620 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN CEQ36_13625 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CEQ36_13630 ENOG41080Z8 PHOSPHOCARRIER protein CEQ36_13635 ENOG4105CSP Major Facilitator Superfamily CEQ36_13640 ENOG4105EXW epimerase dehydratase CEQ36_13645 ENOG4105CXT aspartate transcarbamylase CEQ36_13650 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) CEQ36_13655 ENOG4105KME endoribonuclease L-psp CEQ36_13665 ENOG4105CG3 alpha amylase, catalytic region CEQ36_13670 ENOG4105C5Y PTS System CEQ36_13675 ENOG4105D4X repressor CEQ36_13680 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CEQ36_13690 ENOG41084S7 Plasmid maintenance system antidote protein CEQ36_13695 ENOG4105EMD TRANSCRIPTIONal CEQ36_13710 ENOG41069H0 dihydroorotase EC 3.5.2.3 CEQ36_13740 ENOG4105NXH GreA GreB family elongation factor CEQ36_13745 ENOG4108XVM Cytochrome b(562) CEQ36_13750 ENOG4105CMS peptidase U62, modulator of DNA gyrase CEQ36_13755 ENOG4105N42 UPF0307 protein CEQ36_13760 ENOG4105UNR (Barnase) inhibitor CEQ36_13770 ENOG4105C26 Dehydrogenase CEQ36_13775 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) CEQ36_13780 ENOG4105Y49 secretion protein, HlyD family CEQ36_13790 ENOG4105CR8 Transcriptional regulator CEQ36_13795 ENOG4105D1U peptidase U62 modulator of DNA gyrase CEQ36_13805 ENOG4105QD6 exported protein CEQ36_13810 ENOG4105C03 ribonuclease CEQ36_13820 ENOG4105VQ7 Rod shape-determining protein MreD CEQ36_13825 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CEQ36_13830 ENOG4105DFF Rod shape-determining protein mreb CEQ36_13835 ENOG41062P1 Diguanylate cyclase phosphodiesterase CEQ36_13840 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family CEQ36_13850 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) CEQ36_13860 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CEQ36_13865 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CEQ36_13870 ENOG4105RG0 Membrane CEQ36_13875 ENOG4108IA2 Sodium pantothenate symporter CEQ36_13880 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CEQ36_13885 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CEQ36_13890 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) CEQ36_13895 ENOG4108XTF Outer Membrane Lipoprotein CEQ36_13900 ENOG4105VEQ Cold shock protein CEQ36_13905 ENOG4105VEQ Cold shock protein CEQ36_13910 ENOG4107QPK )-transporter CEQ36_13915 ENOG4105C2X Arabinose 5-phosphate isomerase CEQ36_13920 ENOG4105EF1 ribulokinase CEQ36_13930 ENOG4105CNN ABC, transporter CEQ36_13935 ENOG4105C2J ABC transporter CEQ36_13945 ENOG4105D1S lipid A biosynthesis CEQ36_13960 ENOG4105EZ7 amino acid ABC transporter CEQ36_13965 ENOG4105DRP amino acid AbC transporter CEQ36_13970 ENOG4105CDA abc transporter atp-binding protein CEQ36_13985 ENOG4105CMU LysR family (Transcriptional regulator CEQ36_13990 ENOG4105EEQ Na H antiporter CEQ36_13995 ENOG4105C7N Xanthine uracil vitamin C permease CEQ36_14015 ENOG4108UUM single-stranded DNA-binding protein CEQ36_14020 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CEQ36_14025 ENOG4105MSB protein, conserved in bacteria CEQ36_14030 ENOG4105CGF Aromatic amino acid aminotransferase CEQ36_14035 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CEQ36_14040 ENOG4105CDU Replicative dna helicase CEQ36_14045 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CEQ36_14050 ENOG4105P4Z Phage shock protein G CEQ36_14055 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CEQ36_14060 ENOG4105MYN Zinc uptake regulation protein CEQ36_14065 ENOG4105VDW Csbd family CEQ36_14070 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CEQ36_14075 ENOG41080IJ Diacylglycerol kinase CEQ36_14080 ENOG4105E55 glycerol-3-phosphate acyltransferase CEQ36_14090 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) CEQ36_14095 ENOG4107W52 maltose operon periplasmic protein CEQ36_14100 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CEQ36_14115 ENOG4107FKK extracellular solute-binding protein family 1 CEQ36_14120 ENOG4105D56 permease protein CEQ36_14125 ENOG4105EG2 ABC transporter, permease CEQ36_14130 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CEQ36_14140 ENOG4105CFH Aspartokinase CEQ36_14145 ENOG4105C09 Bile acid CEQ36_14160 ENOG4105C3R Methionine synthase CEQ36_14165 ENOG41069M3 Transcriptional regulator CEQ36_14170 ENOG4105BZU Histidine kinase CEQ36_14175 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CEQ36_14180 ENOG4107QP7 CoA-transferase subunit A CEQ36_14185 ENOG4107QNJ CoA-transferase subunit B CEQ36_14190 ENOG4105CRW Short chain fatty acid transporter CEQ36_14195 ENOG4105CHU acetyl-coa acetyltransferase CEQ36_14200 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) CEQ36_14205 ENOG4108I9X Isocitrate lyase CEQ36_14210 ENOG4107QP3 malate synthase g CEQ36_14215 ENOG4105CVG Homoserine O-transsuccinylase CEQ36_14260 ENOG4108Z0R Transferase CEQ36_14265 ENOG4105E2X shikimate dehydrogenase CEQ36_14270 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CEQ36_14275 ENOG4108WI1 Dna topoisomerase CEQ36_14285 ENOG4105C79 DNA protecting protein DprA CEQ36_14290 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CEQ36_14295 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CEQ36_14300 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CEQ36_14305 ENOG4105C1A potassium transporter peripheral membrane CEQ36_14310 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CEQ36_14315 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system CEQ36_14320 ENOG4105W1Y Transcriptional regulator CEQ36_14325 ENOG4105VTS DnaJ-like, subfamily C CEQ36_14330 ENOG4108ZT0 50S ribosomal protein l17 CEQ36_14335 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CEQ36_14340 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CEQ36_14345 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CEQ36_14350 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CEQ36_14355 ENOG41067V7 50S ribosomal protein L36 CEQ36_14360 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CEQ36_14365 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CEQ36_14370 ENOG4105VPB 50S ribosomal protein L30 CEQ36_14375 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CEQ36_14380 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CEQ36_14385 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CEQ36_14390 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CEQ36_14395 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CEQ36_14405 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CEQ36_14410 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CEQ36_14415 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CEQ36_14420 ENOG41083MP 50s ribosomal protein l29 CEQ36_14425 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CEQ36_14430 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CEQ36_14440 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CEQ36_14450 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CEQ36_14480 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CEQ36_14495 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CEQ36_14505 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CEQ36_14510 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CEQ36_14515 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) CEQ36_14520 ENOG4105WWK YheO domain protein CEQ36_14525 ENOG4108V1T peptidylprolyl cis-trans isomerase CEQ36_14535 ENOG4108YZY peptidylprolyl cis-trans isomerase CEQ36_14540 ENOG4105VKU nucleicacid-binding protein CEQ36_14550 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CEQ36_14555 ENOG4105C5H ABC transporter CEQ36_14560 ENOG4105K64 Glycosyl transferase, family 2 CEQ36_14570 ENOG4105E2B Taurine dioxygenase CEQ36_14575 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CEQ36_14585 ENOG4106FTQ Taurine ABC transporter, periplasmic CEQ36_14590 ENOG4105JAB phenazine biosynthesis protein, phzf family CEQ36_14600 ENOG4105DNZ Alpha Beta Hydrolase CEQ36_14605 ENOG4105YP7 UPF0270 protein CEQ36_14610 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) CEQ36_14615 ENOG4108UKZ OsmC family CEQ36_14625 ENOG410613R integral membrane protein, YccS YhfK family CEQ36_14630 ENOG4105C8Y Acetylornithine aminotransferase CEQ36_14640 ENOG4105D7A ATP-binding protein CEQ36_14645 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CEQ36_14655 ENOG4105F8D glycoside hydrolase family 4 CEQ36_14660 ENOG41060NJ transcriptional regulator CEQ36_14665 ENOG4107RNH Outer membrane receptor FepA CEQ36_14675 ENOG4106DTQ Protein TsgA homolog CEQ36_14680 ENOG4105DZC cytosine deaminase CEQ36_14685 ENOG4107QZF nitrite reductase NADPH large subunit CEQ36_14690 ENOG4105WZK nitrite reductase NADPH small subunit CEQ36_14695 ENOG4107V9H nitrite transporter CEQ36_14700 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CEQ36_14705 ENOG4105C31 Tryptophanyl-tRNA synthetase CEQ36_14715 ENOG4105DJV ribulose-phosphate 3-epimerase CEQ36_14740 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CEQ36_14745 ENOG4105E4G Type IV pilus CEQ36_14770 ENOG4108JQC penicillin-binding protein 1A CEQ36_14775 ENOG4107RK2 ADP-ribose diphosphatase NudE CEQ36_14780 ENOG4105DQY intracellular growth attenuator CEQ36_14785 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 CEQ36_14790 ENOG4105VEJ Heat shock protein CEQ36_14815 ENOG4105E0F Histidine kinase CEQ36_14820 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CEQ36_14825 ENOG4108RRZ Transcription elongation factor GreB CEQ36_14830 ENOG4105BZM domain protein CEQ36_14835 ENOG4105XFK Ferrous iron transport protein A CEQ36_14840 ENOG4105CE1 Ferrous iron transport protein b CEQ36_14845 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) CEQ36_14850 ENOG4105RID UPF0379 protein yhcN CEQ36_14855 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CEQ36_14860 ENOG4105MJ2 Competence protein CEQ36_14865 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) CEQ36_14875 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) CEQ36_14880 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CEQ36_14885 ENOG41061ZR Transcriptional regulator CEQ36_14895 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) CEQ36_14900 ENOG4105E98 transcriptional regulator DeoR family CEQ36_14905 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CEQ36_14910 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CEQ36_14915 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CEQ36_14920 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CEQ36_14925 ENOG4108IUM Glycogen debranching enzyme CEQ36_14930 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CEQ36_14935 ENOG4108HRK Histidine kinase CEQ36_14950 ENOG4105C7K acetolactate synthase CEQ36_14955 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CEQ36_14960 ENOG41076UM multiple antibiotic resistance (MarC)-related protein CEQ36_14965 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CEQ36_14970 ENOG4105C6Z Gluconate CEQ36_14975 ENOG4105DIQ Transcriptional regulator CEQ36_14980 ENOG4105C2I pirin domain protein CEQ36_14985 ENOG4105WCN acetyltransferase CEQ36_14990 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CEQ36_14995 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CEQ36_15000 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) CEQ36_15015 ENOG4105DH8 myo-inositol catabolism CEQ36_15020 ENOG4105C26 Dehydrogenase CEQ36_15030 ENOG4105EQ0 Major Facilitator superfamily CEQ36_15035 ENOG4105CR8 Transcriptional regulator CEQ36_15045 ENOG41066YJ Beta-lactamase CEQ36_15050 ENOG4105CBX hi0933 family CEQ36_15055 ENOG4105CJ3 phosphate transporter CEQ36_15060 ENOG4108V6B universal stress protein B CEQ36_15065 ENOG4108M6U Universal stress protein A CEQ36_15075 ENOG4105QNJ serralysin (EC 3.4.24.40) CEQ36_15080 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) CEQ36_15085 ENOG4105DGW oligopeptidase A CEQ36_15095 ENOG4105D6S protein involved in catabolism of external DNA CEQ36_15100 ENOG4105DC8 reductase CEQ36_15125 ENOG4105CUZ uba thif-type nad fad binding protein CEQ36_15190 ENOG4107H3J ribonuclease CEQ36_15195 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) CEQ36_15200 ENOG41066T0 asmA family CEQ36_15205 ENOG4105CMB EAL domain-containing protein CEQ36_15210 ENOG4105VSH 4-oxalocrotonate tautomerase CEQ36_15215 ENOG4107SS6 2-dehydro-3-deoxygluconokinase CEQ36_15220 ENOG4105CS0 peptidase CEQ36_15225 ENOG4105CK2 sodium dicarboxylate symporter CEQ36_15240 ENOG4108PU9 oligogalacturonate-specific porin CEQ36_15250 ENOG4105CW0 outer membrane usher protein CEQ36_15255 ENOG4105GQR Chaperone CEQ36_15275 ENOG4105BZU Histidine kinase CEQ36_15280 ENOG4105EJG cellulose synthase CEQ36_15285 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) CEQ36_15290 ENOG4107EEX Cellulose synthase regulator protein CEQ36_15295 ENOG4107QZ7 Cellulose synthase catalytic subunit CEQ36_15300 ENOG4105UTS cellulose synthase operon protein YhjQ CEQ36_15310 ENOG4105U74 cellulose biosynthesis protein BcsE CEQ36_15315 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT CEQ36_15320 ENOG4105D1V cellulose synthase operon protein YhjU CEQ36_15325 ENOG4108JQ7 (ABC) transporter CEQ36_15330 ENOG4105C3U ABC transporter CEQ36_15335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CEQ36_15340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CEQ36_15345 ENOG4105DEF Extracellular solute-binding protein, family 5 CEQ36_15360 ENOG4105CXY transporter CEQ36_15365 ENOG4105BZU Histidine kinase CEQ36_15370 ENOG4108KX4 response regulator CEQ36_15375 ENOG4105DIJ Phosphoethanolamine transferase CEQ36_15380 ENOG4108ZHJ Organic hydroperoxide resistance protein CEQ36_15395 ENOG4105C85 amino acid CEQ36_15400 ENOG4105C84 Histidine ammonia-lyase CEQ36_15405 ENOG4105CGP Urocanate hydratase CEQ36_15420 ENOG4105T16 Transcriptional regulator (AraC family) CEQ36_15425 ENOG4107RNG ABC transporter CEQ36_15435 ENOG4105DFW ABC transporter CEQ36_15440 ENOG4105C93 Xylose Isomerase CEQ36_15445 ENOG4105CMG Carbohydrate kinase CEQ36_15455 ENOG4108TTM chaperone CEQ36_15475 ENOG4108RWI nicotinamidase CEQ36_15485 ENOG4105MEV Acyl-transferase CEQ36_15495 ENOG4105EM7 Selenocysteine-specific translation elongation factor CEQ36_15500 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) CEQ36_15505 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) CEQ36_15510 ENOG4108MG3 formate dehydrogenase CEQ36_15515 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CEQ36_15525 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CEQ36_15530 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CEQ36_15535 ENOG4105C8Q Methyl-accepting chemotaxis CEQ36_15540 ENOG4108RPX mosc domain containing protein CEQ36_15555 ENOG4108YYI Protein of unknown function (DUF2810) CEQ36_15560 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CEQ36_15570 ENOG4105E61 Mannitol repressor protein CEQ36_15575 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase CEQ36_15580 ENOG4105CTS PTS system mannitol-specific CEQ36_15590 ENOG4106JH6 (LipO)protein CEQ36_15595 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CEQ36_15605 ENOG4108R3E Dna-3-methyladenine glycosylase i CEQ36_15610 ENOG4105HNP -acetyltransferase CEQ36_15625 ENOG4108ZG0 Ompa motb domain protein CEQ36_15645 ENOG4107T9C Alpha amylase catalytic region CEQ36_15650 ENOG4105JKW Valine--pyruvate aminotransferase CEQ36_15670 ENOG4105R2A (LipO)protein CEQ36_15675 ENOG4105D99 atp gtp-binding protein CEQ36_15680 ENOG4105DJB Major Facilitator Superfamily CEQ36_15685 ENOG4105CXK mandelate racemase muconate lactonizing CEQ36_15690 ENOG4108RTU Aldolase CEQ36_15695 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 CEQ36_15700 ENOG4105EMF GntR family transcriptional regulator CEQ36_15705 ENOG4108SGR YheO domain-containing protein CEQ36_15710 ENOG4105C7B Threonine dehydratase CEQ36_15720 ENOG4105FDP GntR family transcriptional regulator CEQ36_15725 ENOG4105CS2 ec 3.2.1.21 CEQ36_15735 ENOG4105CK1 PTS System CEQ36_15740 ENOG41066F8 ROK family CEQ36_15750 ENOG4105VCP PTS System CEQ36_15755 ENOG410667J hydrolase CEQ36_15760 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CEQ36_15770 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CEQ36_15775 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CEQ36_15785 ENOG4105VG0 50S ribosomal protein l34 CEQ36_15790 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CEQ36_15800 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CEQ36_15805 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CEQ36_15810 ENOG4105RKW reductase (By CEQ36_15815 ENOG4105D01 (LipO)protein CEQ36_15820 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CEQ36_15825 ENOG4108UMI ABC transporter, permease CEQ36_15830 ENOG4105C8Q Methyl-accepting chemotaxis CEQ36_15835 ENOG4108YYH Nadph-dependent fmn reductase CEQ36_15840 ENOG4105BZU Histidine kinase CEQ36_15860 ENOG4105C7N Xanthine uracil vitamin C permease CEQ36_15865 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 CEQ36_15870 ENOG4105DRP amino acid AbC transporter CEQ36_15875 ENOG4105E5Q amino acid AbC transporter CEQ36_15880 ENOG4106PMH Extracellular solute-binding protein family 3 CEQ36_15900 ENOG4105E2Z phosphate ABC transporter (Permease CEQ36_15905 ENOG4105C8U phosphate abc transporter CEQ36_15915 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) CEQ36_15960 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CEQ36_15965 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CEQ36_15970 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CEQ36_15975 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CEQ36_15985 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CEQ36_15990 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CEQ36_15995 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CEQ36_16000 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CEQ36_16010 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) CEQ36_16015 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation CEQ36_16020 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CEQ36_16025 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CEQ36_16030 ENOG4105QTB Flavodoxin CEQ36_16035 ENOG4108VVK transcriptional Regulator, AsnC CEQ36_16040 ENOG4105CU9 asparagine synthetase A CEQ36_16050 ENOG4105EV2 VWA domain protein interacting with AAA ATPase CEQ36_16055 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) CEQ36_16065 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) CEQ36_16075 ENOG4105CNN ABC, transporter CEQ36_16080 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CEQ36_16085 ENOG4108RVA ribokinase CEQ36_16090 ENOG4105ETE Transcriptional regulator (LacI family CEQ36_16095 ENOG4105C0R drug resistance transporter emrb qaca subfamily CEQ36_16100 ENOG4107EJG GntR family transcriptional regulator CEQ36_16130 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b CEQ36_16140 ENOG4105PC1 Conserved Protein CEQ36_16145 ENOG4105E27 serine threonine protein kinase CEQ36_16150 ENOG4108Z33 Thiol disulfide Interchange Protein CEQ36_16155 ENOG4105C2M dna polymerase I CEQ36_16160 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CEQ36_16175 ENOG4105D4P Coproporphyrinogen iii oxidase CEQ36_16180 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CEQ36_16185 ENOG4105CUX Signal transduction histidine kinase CEQ36_16195 ENOG4105C5F glutamine synthetase CEQ36_16205 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 CEQ36_16210 ENOG4107S2Z UPF0761 membrane protein CEQ36_16215 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CEQ36_16220 ENOG4105SUU thioesterase domain CEQ36_16225 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CEQ36_16240 ENOG4105HVQ Regulatory factor of maltose metabolism CEQ36_16250 ENOG4105JV1 AsmA family CEQ36_16255 ENOG4105C2W permease CEQ36_16260 ENOG4105D6U Sodium Glutamate Symporter CEQ36_16265 ENOG4105CB5 ATP-dependent DNA helicase recG CEQ36_16270 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase CEQ36_16275 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CEQ36_16280 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CEQ36_16290 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) CEQ36_16295 ENOG4105EN6 Membrane CEQ36_16305 ENOG4105D9N nucleoside CEQ36_16310 ENOG4105E39 Enoyl-CoA hydratase CEQ36_16315 ENOG4105BZU Histidine kinase CEQ36_16335 ENOG4105F5P DNA-damage-inducible protein d CEQ36_16340 ENOG4105DSJ YicC domain protein CEQ36_16345 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CEQ36_16350 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CEQ36_16355 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CEQ36_16360 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CEQ36_16365 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CEQ36_16380 ENOG4105KDC 50s ribosomal protein l28 CEQ36_16385 ENOG4105W0E 50S ribosomal protein L33 CEQ36_16395 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CEQ36_16405 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase CEQ36_16410 ENOG4105D16 lipopolysaccharide heptosyltransferase i CEQ36_16415 ENOG4105XA0 heptosyltransferase ii CEQ36_16420 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CEQ36_16425 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CEQ36_16435 ENOG4105PXI polysaccharide deacetylase CEQ36_16440 ENOG41063SB peptidase CEQ36_16445 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CEQ36_16450 ENOG4107YZP Rhodanese domain protein CEQ36_16455 ENOG4105VW4 glutaredoxin 3 CEQ36_16460 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) CEQ36_16465 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CEQ36_16470 ENOG4105D7W serine acetyltransferase CEQ36_16475 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CEQ36_16480 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CEQ36_16485 ENOG4105E0F Histidine kinase CEQ36_16490 ENOG4105E3W Two component transcriptional regulator (Winged helix family CEQ36_16495 ENOG4105FMW periplasmic CEQ36_16510 ENOG4105MRD Phage derived protein Gp49-like (DUF891) CEQ36_16525 ENOG41076HS cation diffusion facilitator family transporter CEQ36_16535 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CEQ36_16545 ENOG4105EBK exported protein CEQ36_16550 ENOG4108VTS Membrane CEQ36_16555 ENOG4105DP0 ferredoxin-NADP reductase CEQ36_16560 ENOG4105E5M Multidrug resistance protein D CEQ36_16565 ENOG4105CBT Fructose-1,6-bisphosphatase CEQ36_16570 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CEQ36_16575 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CEQ36_16590 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) CEQ36_16600 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CEQ36_16605 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CEQ36_16610 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CEQ36_16615 ENOG41063M6 Cell Division Protein CEQ36_16620 ENOG4105ETE Transcriptional regulator (LacI family CEQ36_16625 ENOG4105C25 Primosomal protein n' CEQ36_16630 ENOG4105VFB Binds the 23S rRNA (By similarity) CEQ36_16635 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) CEQ36_16640 ENOG4105C28 cystathionine CEQ36_16645 ENOG4105CFH Aspartokinase CEQ36_16650 ENOG4105SYT Methylenetetrahydrofolate reductase CEQ36_16655 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) CEQ36_16665 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CEQ36_16675 ENOG4105CH7 arginosuccinase CEQ36_16705 ENOG4107QZV Type I secretion membrane fusion protein CEQ36_16725 ENOG4107QN2 dihydrolipoyl dehydrogenase CEQ36_16730 ENOG4105EHV domain protein CEQ36_16735 ENOG4105C5Q Transcriptional regulator CEQ36_16740 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CEQ36_16750 ENOG4108Y73 Membrane CEQ36_16755 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) CEQ36_16765 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CEQ36_16810 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator CEQ36_16815 ENOG4105C2J ABC transporter CEQ36_16820 ENOG4107R9N ABC transporter CEQ36_16825 ENOG41062B0 ABC transporter, permease CEQ36_16830 ENOG4105CVI Transcriptional regulator CEQ36_16835 ENOG4108WFC UPF0438 protein yifE CEQ36_16840 ENOG4105C0P Mg chelatase subunit ChlI CEQ36_16860 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit CEQ36_16865 ENOG4105CM2 brancheD-chain amino acid aminotransferase CEQ36_16875 ENOG4105C7B Threonine dehydratase CEQ36_16885 ENOG4105EMY transcriptional regulator CEQ36_16890 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CEQ36_16900 ENOG4108VEV chaperone CEQ36_16910 ENOG4105CW0 outer membrane usher protein CEQ36_16915 ENOG4105GQR Chaperone CEQ36_16925 ENOG4105KQ5 peptidylprolyl cis-trans isomerase CEQ36_16930 ENOG4105C4R Atp-dependent dna helicase CEQ36_16940 ENOG4105C9X ppx gppa phosphatase CEQ36_16950 ENOG4105K63 Thioredoxin CEQ36_16960 ENOG4105ESV Glycosyl transferase, family 4 CEQ36_16965 ENOG4105SFE lipopolysaccharide biosynthesis protein CEQ36_16970 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CEQ36_16975 ENOG4108IJ1 Dehydrogenase CEQ36_16980 ENOG4105C1B dTDP-glucose 4-6-dehydratase CEQ36_16985 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CEQ36_16990 ENOG4108WJ1 acetyltransferase CEQ36_16995 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CEQ36_17000 ENOG4105EGZ biosynthesis protein CEQ36_17005 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) CEQ36_17020 ENOG4105C85 amino acid CEQ36_17050 ENOG410601J HemY protein CEQ36_17055 ENOG4105ECF c-methyltransferase CEQ36_17060 ENOG41076E6 Uroporphyrinogen-III Synthase CEQ36_17065 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CEQ36_17080 ENOG4105S7Z (LipO)protein CEQ36_17085 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CEQ36_17090 ENOG4105CT0 Protein of unknown function, DUF484 CEQ36_17095 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CEQ36_17100 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant CEQ36_17105 ENOG4105C4R Atp-dependent dna helicase CEQ36_17115 ENOG4105EQN UPF0261 protein CEQ36_17130 ENOG4107QUT magnesium and cobalt transport protein CorA CEQ36_17135 ENOG4105FR1 rard protein CEQ36_17140 ENOG4108VUY thioesterase Superfamily protein CEQ36_17145 ENOG4105HDD phospholipase CEQ36_17150 ENOG4105C9U ATP-dependent DNA helicase RecQ CEQ36_17155 ENOG4105CCF Lysine exporter protein (Lyse ygga) CEQ36_17165 ENOG4108EUD Lysophospholipase CEQ36_17170 ENOG4105DQF Hydrolase CEQ36_17175 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CEQ36_17180 ENOG4105CXY transporter CEQ36_17185 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A CEQ36_17190 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B CEQ36_17195 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CEQ36_17200 ENOG4108W1V Lipoprotein CEQ36_17205 ENOG4105EX9 Membrane CEQ36_17210 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) CEQ36_17215 ENOG4105C59 p-type ATPase CEQ36_17220 ENOG4107FS9 Membrane CEQ36_17235 ENOG4105MG3 Membrane CEQ36_17240 ENOG4106H78 methyltransferase CEQ36_17245 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CEQ36_17250 ENOG4105CAK Cell division ATP-binding protein ftsE CEQ36_17255 ENOG4105CRP Part of the ABC transporter FtsEX involved in CEQ36_17265 ENOG4105U59 -acetyltransferase CEQ36_17270 ENOG4105CP9 extracellular ligand-binding receptor CEQ36_17275 ENOG4105C32 Amino acid ABC transporter (Permease) CEQ36_17280 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CEQ36_17285 ENOG4105C0Z ABC transporter CEQ36_17290 ENOG4108IV0 ABC, transporter CEQ36_17325 ENOG4105BZ7 extracellular solute-binding protein family 1 CEQ36_17330 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component CEQ36_17335 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CEQ36_17340 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CEQ36_17345 ENOG4107T6V glycerophosphoryl diester phosphodiesterase CEQ36_17350 ENOG4105RK9 auxin efflux carrier CEQ36_17355 ENOG4105EMK carboxylate amino acid amine transporter CEQ36_17360 ENOG4105DZ2 Transcriptional regulator CEQ36_17365 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CEQ36_17370 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) CEQ36_17375 ENOG4108I5U Uridine phosphorylase CEQ36_17390 ENOG4108KF1 Membrane CEQ36_17395 ENOG4105CGY Dna recombination protein CEQ36_17400 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CEQ36_17405 ENOG4105JC1 sterol-binding domain protein CEQ36_17410 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) CEQ36_17415 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CEQ36_17420 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) CEQ36_17425 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CEQ36_17435 ENOG4105D52 delta-aminolevulinic acid dehydratase CEQ36_17440 ENOG4105MDZ Transcriptional activator rfaH CEQ36_17445 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CEQ36_17450 ENOG4107QK7 reductase CEQ36_17455 ENOG4105CHU acetyl-coa acetyltransferase CEQ36_17460 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CEQ36_17470 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CEQ36_17475 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) CEQ36_17480 ENOG4108RR8 protoporphyrinogen oxidase CEQ36_17515 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CEQ36_17520 ENOG4105CS9 pantothenic acid kinase CEQ36_17560 ENOG4105PM1 preprotein translocase subunit SecE CEQ36_17565 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CEQ36_17570 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CEQ36_17575 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CEQ36_17580 ENOG4108VZM 50s ribosomal protein L10 CEQ36_17585 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CEQ36_17590 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CEQ36_17595 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CEQ36_17600 ENOG4105D41 biosynthesis protein thiH CEQ36_17605 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CEQ36_17610 ENOG4105WHD thiamine biosynthesis protein ThiS CEQ36_17615 ENOG4105D06 uba thif-type nad fad binding protein CEQ36_17625 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CEQ36_17630 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor CEQ36_17635 ENOG4105E09 nadh pyrophosphatase CEQ36_17640 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CEQ36_17645 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) CEQ36_17650 ENOG4105R2J Conserved Protein CEQ36_17660 ENOG4108T8B Protein of unknown function (DUF1481) CEQ36_17665 ENOG4105C12 Phosphoribosylglycinamide synthetase CEQ36_17670 ENOG4105DC1 bifunctional purine biosynthesis protein purh CEQ36_17710 ENOG4107QN1 sodium solute CEQ36_17715 ENOG41062QD Membrane CEQ36_17720 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CEQ36_17725 ENOG4105CK2 sodium dicarboxylate symporter CEQ36_17750 ENOG4105UQF type iii secretion CEQ36_17755 ENOG4106H1D secretion system apparatus protein CEQ36_17765 ENOG4108JIR Flagellum-specific ATP synthase CEQ36_17785 ENOG4108HHI Type III secretion system protein CEQ36_17790 ENOG41083GP type iii secretion CEQ36_17795 ENOG4108TN6 type iii secretion CEQ36_17800 ENOG4108IUF type iii secretion CEQ36_17810 ENOG4105EGS Mechanosensitive ion channel CEQ36_17815 ENOG4105E0K tonB-dependent siderophore receptor CEQ36_17825 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CEQ36_17830 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CEQ36_17835 ENOG4105EHG Permease protein CEQ36_17840 ENOG4107R4I Periplasmic binding protein CEQ36_17845 ENOG4106QJH hemin transport protein CEQ36_17850 ENOG4107ENK receptor CEQ36_17855 ENOG4107F3C Hemin uptake protein CEQ36_17860 ENOG4105C5H ABC transporter CEQ36_17865 ENOG4105C7B Threonine dehydratase CEQ36_17870 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) CEQ36_17875 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CEQ36_17880 ENOG4105C6N Formate acetyltransferase CEQ36_17885 ENOG4105C8Q Methyl-accepting chemotaxis CEQ36_17895 ENOG4105C5Y PTS System CEQ36_17900 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CEQ36_17905 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) CEQ36_17910 ENOG4105D17 glycoside hydrolase, family 3 domain protein CEQ36_17920 ENOG4105EHZ conserved protein UCP016719 CEQ36_17930 ENOG4108SIC Transcriptional regulator CEQ36_17935 ENOG4105CNV Aldolase CEQ36_17940 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CEQ36_17945 ENOG4105BZW Glycerate kinase CEQ36_17950 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR CEQ36_17955 ENOG4105CTX dehydratase CEQ36_17960 ENOG4105DJB Major Facilitator Superfamily CEQ36_17965 ENOG4105BZ8 glutamate synthase CEQ36_17970 ENOG4108RC0 Electron transport protein CEQ36_17975 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CEQ36_17980 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CEQ36_17990 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CEQ36_18005 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CEQ36_18010 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CEQ36_18015 ENOG4108ZVF (LipO)protein CEQ36_18020 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CEQ36_18035 ENOG4105KPY Small multidrug resistance protein CEQ36_18045 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) CEQ36_18050 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) CEQ36_18065 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) CEQ36_18070 ENOG4105EGS Mechanosensitive ion channel CEQ36_18075 ENOG4105DJ4 phosphatidylserine decarboxylase CEQ36_18080 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CEQ36_18085 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) CEQ36_18110 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CEQ36_18115 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CEQ36_18120 ENOG4105K8N protein family UPF0079, ATPase CEQ36_18125 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CEQ36_18130 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CEQ36_18135 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CEQ36_18145 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CEQ36_18150 ENOG4107QJR hflk protein CEQ36_18155 ENOG4105EPW hflc protein CEQ36_18165 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CEQ36_18170 ENOG4105KPV Transcriptional regulator CEQ36_18175 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CEQ36_18180 ENOG4105C2N RNA methyltransferase TrmH family group 3 CEQ36_18190 ENOG4105CSU acyl-Coa dehydrogenase CEQ36_18195 ENOG4105WSB biofilm stress and motility protein A CEQ36_18200 ENOG4108MXZ Esterase CEQ36_18205 ENOG4105RID UPF0379 protein yhcN CEQ36_18220 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CEQ36_18225 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) CEQ36_18230 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CEQ36_18235 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CEQ36_18245 ENOG4105FHY Opacity-associated protein A CEQ36_18250 ENOG4108V1T peptidylprolyl cis-trans isomerase CEQ36_18260 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic CEQ36_18265 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase CEQ36_18270 ENOG4108UUE Transcriptional regulator CEQ36_18275 ENOG41061GZ Protein of unknown function (DUF1107) CEQ36_18280 ENOG4105C37 (CBS) domain CEQ36_18285 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CEQ36_18290 ENOG4105CFU surface antigen CEQ36_18295 ENOG4105MA0 exported protein CEQ36_18300 ENOG4108ZHD aig2 family CEQ36_18305 ENOG4105F0N pyrophosphate phospho-hydrolase CEQ36_18310 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 CEQ36_18315 ENOG4105DFU Cell wall formation (By similarity) CEQ36_18340 ENOG4105HVQ Regulatory factor of maltose metabolism CEQ36_18355 ENOG4105EAH synthase CEQ36_18370 ENOG4105QYV Membrane CEQ36_18375 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CEQ36_18390 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase CEQ36_18395 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CEQ36_18400 ENOG4105HBR Rna-binding protein CEQ36_18405 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) CEQ36_18410 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CEQ36_18415 ENOG4105EEI dihydropteroate synthase CEQ36_18445 ENOG4105CHV Transcription elongation factor NusA CEQ36_18455 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CEQ36_18460 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CEQ36_18470 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CEQ36_18485 ENOG4105C1J atp-dependent rna helicase CEQ36_18490 ENOG4105DEN Luciferase family CEQ36_18495 ENOG4106RZ4 Peptidase U32 CEQ36_18500 ENOG4105CFP Peptidase U32 CEQ36_18505 ENOG4105XPQ lipid carrier protein CEQ36_18510 ENOG4108YYD acetyltransferase CEQ36_18515 ENOG41082IR Excinuclease ABC C subunit domain protein CEQ36_18520 ENOG4105D5Q Arginine ornithine antiporter CEQ36_18525 ENOG4105CXN decarboxylase CEQ36_18530 ENOG4108ZPB UPF0306 protein CEQ36_18535 ENOG4105K4T epimerase CEQ36_18540 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein CEQ36_18545 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) CEQ36_18550 ENOG4105FD8 phosphonate metabolism protein PhnM CEQ36_18555 ENOG4105HRV phosphonate c-p lyase system protein phnl CEQ36_18560 ENOG4105ENV phosphonate C-P lyase system protein PhnK CEQ36_18565 ENOG4105FT8 Phosphonate metabolism CEQ36_18570 ENOG4105EKV Phosphonate metabolism protein CEQ36_18575 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH CEQ36_18580 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG CEQ36_18585 ENOG4107RJJ Transcriptional regulator CEQ36_18595 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) CEQ36_18600 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CEQ36_18605 ENOG410642W LysR family Transcriptional regulator CEQ36_18610 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CEQ36_18615 ENOG4108JQ7 (ABC) transporter CEQ36_18620 ENOG4105C3U ABC transporter CEQ36_18625 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CEQ36_18630 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CEQ36_18640 ENOG4105XEP YhcH YjgK YiaL family protein CEQ36_18650 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) CEQ36_18655 ENOG4108MJ3 acetyltransferase CEQ36_18665 ENOG4105MYG DNA polymerase iii, chi subunit CEQ36_18670 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CEQ36_18675 ENOG4108M8S permease YjgP YjgQ family protein CEQ36_18680 ENOG4108K5H permease YjgP YjgQ family protein CEQ36_18755 ENOG4108P8R CEQ36_18765 ENOG4105JXR Protein of unknown function (DUF3296) CEQ36_18770 ENOG4105TS0 gtp-binding protein CEQ36_18790 ENOG4106H6R UPF0380 protein CEQ36_18800 ENOG4105MFG Antirestriction protein CEQ36_18805 ENOG4108XS9 dna repair protein CEQ36_18825 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles CEQ36_18870 ENOG4105TNG K13735 adhesin invasin CEQ36_18895 ENOG4108FZ9 Chaperone CEQ36_18940 ENOG4105CKT filamentous hemagglutinin CEQ36_18955 ENOG4105CKT filamentous hemagglutinin CEQ36_18990 ENOG4105CKT filamentous hemagglutinin CEQ36_19045 ENOG4107Y60 (LipO)protein CEQ36_19055 ENOG4106B0W Curli production assembly transport component CsgG CEQ36_19075 ENOG4105CKT filamentous hemagglutinin CEQ36_19100 ENOG4105D5K Hemolysin activator protein CEQ36_19125 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF CEQ36_19135 ENOG4105RI1 glycoprotein receptor CEQ36_19140 ENOG4107SEY Conserved Protein CEQ36_19165 ENOG4105DHQ Histidine kinase CEQ36_19175 ENOG41061GT Aldolase CEQ36_19180 ENOG4105D4B ABC, transporter CEQ36_19185 ENOG4105F5R ABC transporter CEQ36_19190 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CEQ36_19195 ENOG4105C2J ABC transporter CEQ36_19200 ENOG4105DKT Transcriptional regulator CEQ36_19205 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) CEQ36_19210 ENOG4105DKP glycosyl transferase, family 9 CEQ36_19220 ENOG4105D5Q Arginine ornithine antiporter CEQ36_19225 ENOG4105CEU Arginine dihydrolase CEQ36_19240 ENOG410624X efflux transporter, rnd family, mfp subunit CEQ36_19245 ENOG4105BZS acriflavin resistance protein CEQ36_19255 ENOG4105CMT Dihydroxyacetone kinase CEQ36_19260 ENOG4108UTZ Dihydroxyacetone kinase CEQ36_19265 ENOG4105VDH Dihydroxyacetone kinase CEQ36_19310 ENOG4105WBN Transcriptional regulator (LacI family CEQ36_19315 ENOG4108HKT sucrose-6-phosphate hydrolase CEQ36_19330 ENOG4105D7K pfkb domain protein CEQ36_19335 ENOG4105BZU Histidine kinase CEQ36_19340 ENOG4105YBH Protein of unknown function (DUF1435) CEQ36_19365 ENOG4105CPC Aldo Keto reductase CEQ36_19375 ENOG4108WPU DNA polymerase III subunit psi CEQ36_19380 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CEQ36_19385 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CEQ36_19390 ENOG4105K3G Periplasmic Protein CEQ36_19400 ENOG4108NRW Phospholipase, patatin family CEQ36_19405 ENOG4105EYA deoxyribonuclease CEQ36_19410 ENOG4105D9N nucleoside CEQ36_19415 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CEQ36_19420 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CEQ36_19425 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CEQ36_19440 ENOG4105EUP HipA domain protein CEQ36_19445 ENOG41062Z9 Membrane CEQ36_19455 ENOG4105EAC phosphoserine phosphatase CEQ36_19460 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CEQ36_19465 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase CEQ36_19470 ENOG4105CIS alcohol dehydrogenase CEQ36_19485 ENOG4105C0A alcohol dehydrogenase CEQ36_19525 ENOG4105C5H ABC transporter CEQ36_19535 ENOG41090EK ompa motb domain protein CEQ36_19540 ENOG4108KHX Diguanylate cyclase CEQ36_19545 ENOG4108WS1 CEQ36_19555 ENOG4107SC1 transglycosylase CEQ36_19560 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) CEQ36_19565 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CEQ36_19575 ENOG4105UEI Transcriptional Regulator AraC Family CEQ36_19580 ENOG4108RH0 Crea protein CEQ36_19585 ENOG41065U4 response regulator CEQ36_19600 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CEQ36_19610 ENOG4105D1Q UPF0246 protein CEQ36_19615 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CEQ36_19620 ENOG4108RIR Molybdenum cofactor biosynthesis protein CEQ36_19635 ENOG4106HK8 GPR1 FUN34 yaaH family protein CEQ36_19645 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CEQ36_19650 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CEQ36_19655 ENOG41063Z6 transcriptional regulator, lysR family CEQ36_19670 ENOG4105DTN riboflavin biosynthesis protein ribF CEQ36_19675 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CEQ36_19680 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CEQ36_19685 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase CEQ36_19690 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CEQ36_19700 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CEQ36_19705 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CEQ36_19710 ENOG4105N14 lysine exporter protein LysE YggA CEQ36_19715 ENOG4105DWK Membrane CEQ36_19725 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CEQ36_19730 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CEQ36_19735 ENOG4105NWN ApaG protein CEQ36_19740 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CEQ36_19750 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) CEQ36_19755 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) CEQ36_19760 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) CEQ36_19765 ENOG4105D3G Pseudouridine synthase CEQ36_19770 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) CEQ36_19775 ENOG4105CQ2 DNA polymerase CEQ36_19785 ENOG4108KF1 Membrane CEQ36_19795 ENOG4106SMU thiamine transporter membrane protein CEQ36_19800 ENOG4105DP9 ABC transporter CEQ36_19810 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CEQ36_19815 ENOG4105F1A Pyruvate formate-lyase CEQ36_19820 ENOG4105C6N Formate acetyltransferase CEQ36_19825 ENOG4105S8Q sugar efflux transporter CEQ36_19830 ENOG4105CIC tryptophan-specific transport protein CEQ36_19835 ENOG4105C0F tryptophanase EC 4.1.99.1 CEQ36_19850 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CEQ36_19855 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CEQ36_19860 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CEQ36_19865 ENOG41064T2 transcriptional regulator, lysR family CEQ36_19870 ENOG4108IQE Amp-dependent synthetase and ligase CEQ36_19875 ENOG4105C7K acetolactate synthase CEQ36_19880 ENOG4108ZP8 Acetolactate synthase small subunit CEQ36_19885 ENOG4107B7Y DNA-binding transcriptional regulator FruR CEQ36_19900 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CEQ36_19905 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CEQ36_19910 ENOG4105CJN penicillin-binding protein CEQ36_19915 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CEQ36_19920 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) CEQ36_19925 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CEQ36_19935 ENOG4105CNI cell division protein FtsW CEQ36_19940 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CEQ36_19945 ENOG4105DFU Cell wall formation (By similarity) CEQ36_19955 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) CEQ36_19960 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CEQ36_19965 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CEQ36_19980 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) CEQ36_19990 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CEQ36_19995 ENOG4105M6F mutator MutT protein CEQ36_20000 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) CEQ36_20010 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CEQ36_20020 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CEQ36_20025 ENOG4105D7Q type ii secretion system CEQ36_20030 ENOG4107QHF type ii secretion system protein e CEQ36_20035 ENOG4108ZUW Major pilin subunit CEQ36_20040 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CEQ36_20050 ENOG4106A72 regulatory protein AmpE CEQ36_20055 ENOG4105C85 amino acid CEQ36_20065 ENOG41073TP transcriptional regulator CEQ36_20070 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CEQ36_20075 ENOG4107QSN dihydrolipoamide acetyltransferase CEQ36_20080 ENOG4107QN2 dihydrolipoyl dehydrogenase CEQ36_20090 ENOG4107RNH Outer membrane receptor FepA CEQ36_20100 ENOG4107QIJ Aconitate hydratase 2 CEQ36_20105 ENOG4108ZIG UPF0231 protein CEQ36_20115 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CEQ36_20120 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CEQ36_20125 ENOG4108ZRK uncharacterized protein yacC CEQ36_20130 ENOG4105E3B Multicopper oxidase CEQ36_20135 ENOG4108UGV hypoxanthine phosphoribosyltransferase CEQ36_20140 ENOG41077A9 carbonic anhydrase CEQ36_20145 ENOG4105DA5 (ABC) transporter CEQ36_20150 ENOG4105E3A (ABC) transporter CEQ36_20155 ENOG4107BJW polysaccharide deacetylase CEQ36_20160 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CEQ36_20170 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CEQ36_20175 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CEQ36_20180 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CEQ36_20185 ENOG4105DJ0 Poly(A) Polymerase CEQ36_20195 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters CEQ36_20200 ENOG4105PW4 Sugar fermentation stimulation protein homolog CEQ36_20205 ENOG4107XID 2'-5' rna ligase CEQ36_20210 ENOG4105CQ7 ATP-dependent helicase CEQ36_20215 ENOG4105BZ4 penicillin-binding protein CEQ36_20220 ENOG4105E0A ABC, transporter CEQ36_20225 ENOG4105J76 Periplasmic binding protein CEQ36_20230 ENOG4105S6R Iron-hydroxamate transporter permease subunit CEQ36_20235 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CEQ36_20245 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CEQ36_20250 ENOG4105EN6 Membrane CEQ36_20260 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CEQ36_20265 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein CEQ36_20270 ENOG4105C0H protease CEQ36_20275 ENOG4105BZU Histidine kinase CEQ36_20280 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CEQ36_20285 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CEQ36_20290 ENOG4105DXN mazG family CEQ36_20295 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CEQ36_20300 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CEQ36_20310 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CEQ36_20315 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CEQ36_20320 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CEQ36_20325 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CEQ36_20330 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CEQ36_20350 ENOG4108MXK alkaline phosphatase isozyme conversion CEQ36_20355 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CEQ36_20360 ENOG4105C11 sulfate adenylyltransferase), subunit 2 CEQ36_20365 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) CEQ36_20370 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CEQ36_20375 ENOG4105N0Z inner membrane protein ygbE CEQ36_20385 ENOG4105DRP amino acid AbC transporter CEQ36_20390 ENOG4106PMH Extracellular solute-binding protein family 3 CEQ36_20395 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CEQ36_20405 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CEQ36_20410 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) CEQ36_20415 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) CEQ36_20420 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CEQ36_20425 ENOG4108K5P (LipO)protein CEQ36_20430 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CEQ36_20435 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CEQ36_20460 ENOG4105F8V Hydrolase, tatD family CEQ36_20530 ENOG4105ESI atpase involved in dna repair CEQ36_20565 ENOG4106PG1 outer membrane usher protein CEQ36_20570 ENOG4108FZ9 Chaperone CEQ36_20585 ENOG4105NEV Fimbrial CEQ36_20590 ENOG4105H8W Fimbrial protein CEQ36_20605 ENOG4108Z33 Thiol disulfide Interchange Protein CEQ36_20615 ENOG4108JJA ABC, transporter CEQ36_20620 ENOG4105DJY efflux transporter, rnd family, mfp subunit CEQ36_20625 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEQ36_20630 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CEQ36_20635 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CEQ36_20650 ENOG4105CHR reductase CEQ36_20655 ENOG4105CXK mandelate racemase muconate lactonizing CEQ36_20660 ENOG4105DEF Extracellular solute-binding protein, family 5 CEQ36_20665 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CEQ36_20670 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CEQ36_20680 ENOG4108JQ7 (ABC) transporter CEQ36_20685 ENOG4105W8I Transcriptional regulator CEQ36_20695 ENOG4105BZC d-serine deaminase CEQ36_20700 ENOG4105DFH Transport of potassium into the cell (By similarity) CEQ36_20705 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CEQ36_20710 ENOG4105YVS arsR family transcriptional regulator CEQ36_20715 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein CEQ36_20720 ENOG4105F3R pts system mannose fructose sorbose family iid CEQ36_20725 ENOG4105ETZ PTS System CEQ36_20730 ENOG4105KPI PTS system sorbose subfamily IIB component CEQ36_20735 ENOG4108XCU pts system CEQ36_20740 ENOG4105DKT Transcriptional regulator CEQ36_20765 ENOG4108IV0 ABC, transporter CEQ36_20770 ENOG4108IUZ ABC transporter CEQ36_20775 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CEQ36_20780 ENOG4105C32 Amino acid ABC transporter (Permease) CEQ36_20790 ENOG4107GFK fumarate CEQ36_20795 ENOG4105CMG Carbohydrate kinase CEQ36_20800 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase CEQ36_20805 ENOG4105F5R ABC transporter CEQ36_20810 ENOG4105CNN ABC, transporter CEQ36_20815 ENOG4105C2J ABC transporter CEQ36_20825 ENOG4105E98 transcriptional regulator DeoR family CEQ36_20830 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase CEQ36_20835 ENOG4107EDW L-fucose operon activator CEQ36_20845 ENOG4105CMG Carbohydrate kinase CEQ36_20855 ENOG4105EDR glucose galactose transporter CEQ36_20860 ENOG4107W7X Aldolase CEQ36_20865 ENOG4105C0A alcohol dehydrogenase CEQ36_20870 ENOG4107QY8 reductase CEQ36_20875 ENOG4105QAX Iron-sulfur CEQ36_20880 ENOG4107KGK dmso reductase anchor subunit CEQ36_20885 ENOG4108NEM leader-binding protein dmsD CEQ36_20900 ENOG4105ETE Transcriptional regulator (LacI family CEQ36_20910 ENOG4105C2J ABC transporter CEQ36_20915 ENOG4105CNN ABC, transporter CEQ36_20920 ENOG4108HHA Transketolase CEQ36_20925 ENOG4108IUS Transketolase CEQ36_20930 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CEQ36_20955 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CEQ36_20960 ENOG4105Y3E Modulates RecA activity (By similarity) CEQ36_20965 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CEQ36_20970 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CEQ36_20995 ENOG4107VXZ Hydrolase CEQ36_21000 ENOG4105W39 Membrane CEQ36_21005 ENOG4105D9M gamma-glutamylcysteine synthetase CEQ36_21010 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) CEQ36_21015 ENOG4108JU6 CBS domain protein CEQ36_21020 ENOG4106KVJ cytochrome C assembly protein CEQ36_21025 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CEQ36_21030 ENOG4105K5M 30s ribosomal protein S16 CEQ36_21040 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CEQ36_21045 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CEQ36_21050 ENOG4108NE3 Salt-induced outer membrane protein CEQ36_21055 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CEQ36_21060 ENOG4108NEV two component transcriptional regulator, LytTR family CEQ36_21065 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CEQ36_21075 ENOG4105CQC Prephenate dehydratase CEQ36_21085 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA CEQ36_21090 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CEQ36_21100 ENOG4105C34 Pseudouridine synthase CEQ36_21105 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CEQ36_21110 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CEQ36_21185 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CEQ36_21215 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CEQ36_21225 ENOG4105C2D reductase CEQ36_21230 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CEQ36_21240 ENOG4105HEI LysR family (Transcriptional regulator CEQ36_21245 ENOG4105F27 Major Facilitator CEQ36_21250 ENOG4107NA1 Endonuclease Exonuclease phosphatase CEQ36_21255 ENOG4105E9H Lytic Murein transglycosylase CEQ36_21260 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CEQ36_21265 ENOG4105D1A Methyltransferase CEQ36_21275 ENOG4108JDX DNA polymerase iii, epsilon subunit CEQ36_21305 ENOG4105GIJ Glycine betaine CEQ36_21310 ENOG4108HQS Glycine betaine CEQ36_21315 ENOG4108IJ7 Glycine betaine CEQ36_21320 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CEQ36_21330 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CEQ36_21335 ENOG4105WAZ (Glutaredoxin-like protein) NrdH CEQ36_21345 ENOG4105NE1 Conserved Protein CEQ36_21365 ENOG4108WMJ Protein of unknown function (DUF2002) CEQ36_21370 ENOG4108SAJ Protein of unknown function (DUF1198) CEQ36_21380 ENOG4105VEQ Cold shock protein CEQ36_21410 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CEQ36_21415 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CEQ36_21420 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CEQ36_21425 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) CEQ36_21445 ENOG4105CQM Urea amidohydrolase subunit alpha CEQ36_21455 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CEQ36_21460 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CEQ36_21480 ENOG4105XXV Acid-resistance protein CEQ36_21485 ENOG4107SVH Potassium channel protein CEQ36_21490 ENOG41086WQ Protein CrcB homolog CEQ36_21500 ENOG4105CPC Aldo Keto reductase CEQ36_21505 ENOG4105D8V Glucose sorbosone dehydrogenase CEQ36_21510 ENOG4105VZJ PTS System CEQ36_21515 ENOG4105CK1 PTS System CEQ36_21520 ENOG4105CS2 ec 3.2.1.21 CEQ36_21525 ENOG4105VCP PTS System CEQ36_21530 ENOG4105EZV Transcriptional regulator CEQ36_21535 ENOG410901P UPF0249 protein CEQ36_21575 ENOG4105Y0G tail protein CEQ36_21605 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CEQ36_21610 ENOG4108Z1B Cyclase dehydrase CEQ36_21620 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CEQ36_21625 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CEQ36_21630 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CEQ36_21640 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CEQ36_21645 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CEQ36_21650 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) CEQ36_21665 ENOG4105C1J atp-dependent rna helicase CEQ36_21670 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) CEQ36_21675 ENOG4108IYU L-aspartate oxidase CEQ36_21685 ENOG41069PW sigma-e factor negative regulatory protein CEQ36_21690 ENOG4105VQK sigma E regulatory protein, MucB RseB CEQ36_21695 ENOG4105WMJ Positive regulator of sigma E, RseC MucC CEQ36_21705 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CEQ36_21710 ENOG4105C3F Signal peptidase i CEQ36_21720 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CEQ36_21725 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) CEQ36_21730 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) CEQ36_21735 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CEQ36_21740 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding CEQ36_21745 ENOG4106G6Q Transcriptional regulator CEQ36_21760 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB CEQ36_21770 ENOG4108Z6B deaminase CEQ36_21775 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) CEQ36_21790 ENOG4107WP9 Histidine kinase CEQ36_21795 ENOG4108SKK alpha helix protein CEQ36_21800 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CEQ36_21805 ENOG4105C4K Nad synthetase CEQ36_21810 ENOG4108YZA Nitrogen regulatory protein pii CEQ36_21815 ENOG4106M0N transport system permease protein CEQ36_21820 ENOG4105MUZ Protein of unknown function DUF2620 CEQ36_21825 ENOG41080QX K07048 phosphotriesterase-related protein CEQ36_21830 ENOG4108626 Racemase CEQ36_21835 ENOG4105RMW regulation of transcription, DNA-dependent CEQ36_21840 ENOG4108M21 CEQ36_21845 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CEQ36_21855 ENOG4105D8G Major Facilitator superfamily CEQ36_21860 ENOG4108MN2 Stationary phase inducible protein CsiE CEQ36_21865 ENOG41065CD Exported protein CEQ36_21870 ENOG4105D7X high-affinity nickel-transporter CEQ36_21880 ENOG4105CVS RNA methyltransferase TrmH family, group 1 CEQ36_21885 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family CEQ36_21890 ENOG4105C3J Cysteine desulfurase CEQ36_21895 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins CEQ36_21905 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) CEQ36_21910 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB CEQ36_21915 ENOG4108ZIT Ferredoxin, 2FE-2S CEQ36_21920 ENOG4105WVQ Fe-S assembly protein IscX CEQ36_21930 ENOG4105YYA enhanced serine sensitivity protein SseB CEQ36_21935 ENOG4108MGN ATP-binding component of a transport system CEQ36_21945 ENOG4105DN3 alpha-2-macroglobulin domain protein CEQ36_21950 ENOG4108JQB penicillin-binding protein 1C CEQ36_21970 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CEQ36_21980 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) CEQ36_21995 ENOG4105N21 Membrane CEQ36_22000 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CEQ36_22015 ENOG4105VPD cellular component movement CEQ36_22025 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CEQ36_22030 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CEQ36_22050 ENOG4105DWF phosphomethylpyrimidine kinase CEQ36_22060 ENOG4108ZGU inhibitor of vertebrate lysozyme CEQ36_22070 ENOG410804X Transcriptional regulator CEQ36_22075 ENOG4105J92 DNA-binding transcriptional activator GutM CEQ36_22080 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase CEQ36_22085 ENOG4105VI0 Pts system, glucitol sorbitol-specific CEQ36_22090 ENOG4105DZY Pts system, glucitol sorbitol-specific CEQ36_22095 ENOG410787A Pts system, glucitol sorbitol-specific CEQ36_22100 ENOG4107TE5 Lipid kinase CEQ36_22105 ENOG4105CFP Peptidase U32 CEQ36_22110 ENOG4105KWI UPF0339 protein CEQ36_22115 ENOG4105E3W Two component transcriptional regulator (Winged helix family CEQ36_22120 ENOG4105EB3 Histidine kinase CEQ36_22125 ENOG4105BZS acriflavin resistance protein CEQ36_22135 ENOG4105ENT Efflux transporter rnd family, mfp subunit CEQ36_22140 ENOG4105R8A Heat shock protein CEQ36_22145 ENOG4105BZU Histidine kinase CEQ36_22150 ENOG4105CJW magnesium transporter CEQ36_22160 ENOG4105C9X ppx gppa phosphatase CEQ36_22165 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CEQ36_22170 ENOG4105C8U phosphate abc transporter CEQ36_22175 ENOG4105E2Z phosphate ABC transporter (Permease CEQ36_22190 ENOG4108MK9 spermidine N(1)-acetyltransferase CEQ36_22195 ENOG4108V3E phosphoribosylglycinamide formyltransferase CEQ36_22200 ENOG4105CXB phosphoribosylaminoimidazole synthetase CEQ36_22210 ENOG4105C2W permease CEQ36_22215 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) CEQ36_22220 ENOG4105K89 arsenate reductase CEQ36_22225 ENOG4105ERG peptidase m48, ste24p CEQ36_22230 ENOG4105C02 permease CEQ36_22240 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CEQ36_22245 ENOG4105RH4 Glycine cleavage system transcriptional repressor CEQ36_22250 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CEQ36_22255 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CEQ36_22270 ENOG4105CGZ zinc metallopeptidase CEQ36_22280 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) CEQ36_22290 ENOG4106KED esterase YpfH CEQ36_22295 ENOG4105XYK UPF0370 protein CEQ36_22305 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CEQ36_22310 ENOG4105KUZ arsenate reductase CEQ36_22320 ENOG4105BZS acriflavin resistance protein CEQ36_22330 ENOG4105WH1 Two component transcriptional regulator luxr family CEQ36_22335 ENOG4108ZNS ferredoxin-type protein NapF CEQ36_22340 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase CEQ36_22345 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CEQ36_22350 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) CEQ36_22355 ENOG4105CUW cytochrome C-TYPE protein CEQ36_22370 ENOG4107VIJ nudix hydrolase CEQ36_22375 ENOG4105C6K Malic enzyme CEQ36_22380 ENOG4108UPT UPF0178 protein CEQ36_22385 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) CEQ36_22390 ENOG4108R6G acetyltransferase CEQ36_22425 ENOG4108Q5F Tetr family transcriptional regulator CEQ36_22435 ENOG4105F27 Major Facilitator CEQ36_22500 ENOG4105H4F exported protein CEQ36_22510 ENOG4105E7K (LipO)protein CEQ36_22515 ENOG4105EZR dyp-type peroxidase family protein CEQ36_22520 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein CEQ36_22525 ENOG4108I5D sulfate abc transporter CEQ36_22530 ENOG4105ECW sulfate abc transporter CEQ36_22540 ENOG4105C6T cysteine synthase CEQ36_22550 ENOG4105ECX polysaccharide export CEQ36_22555 ENOG4107V1M polysaccharide export protein CEQ36_22560 ENOG4105E12 capsule polysaccharide CEQ36_22565 ENOG41084CK capsule polysaccharide CEQ36_22575 ENOG4105CMR udp-glucose 4-epimerase CEQ36_22595 ENOG41090SZ ABC-2 type transporter CEQ36_22605 ENOG4105DJY efflux transporter, rnd family, mfp subunit CEQ36_22610 ENOG4105E3W Two component transcriptional regulator (Winged helix family CEQ36_22615 ENOG4105E0F Histidine kinase CEQ36_22620 ENOG4105C5Y PTS System CEQ36_22630 ENOG4105KZ7 phosphocarrier protein hpr CEQ36_22635 ENOG4105C6T cysteine synthase CEQ36_22640 ENOG4105EXN Sulfate transport protein CysZ CEQ36_22650 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CEQ36_22655 ENOG4105VRT cytoplasmic protein CEQ36_22685 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CEQ36_22730 ENOG4105D9N nucleoside CEQ36_22735 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CEQ36_22745 ENOG4105CPC Aldo Keto reductase CEQ36_22750 ENOG4105C5Q Transcriptional regulator CEQ36_22760 ENOG4105CHC glucokinase (EC 2.7.1.2) CEQ36_22765 ENOG4105FCD Major Facilitator CEQ36_22770 ENOG4105DY9 regulatoR CEQ36_22775 ENOG4108HRK Histidine kinase CEQ36_22780 ENOG41072TH Protein of unknown function (DUF1479) CEQ36_22790 ENOG4105CHM Aminotransferase CEQ36_22795 ENOG4108VKM cytochrome b561 CEQ36_22805 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin CEQ36_22815 ENOG4108NEM leader-binding protein dmsD CEQ36_22820 ENOG4107KGK dmso reductase anchor subunit CEQ36_22825 ENOG4105QAX Iron-sulfur CEQ36_22830 ENOG4107QY8 reductase CEQ36_22845 ENOG4105CS2 ec 3.2.1.21 CEQ36_22850 ENOG4105TW1 Carbohydrate-selective porin OprB CEQ36_22860 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CEQ36_22875 ENOG4105CVE Lytic murein transglycosylase CEQ36_22880 ENOG4105CUB amino acid CEQ36_22905 ENOG4105DHJ ABC, transporter CEQ36_22920 ENOG4105CEM UPF0597 protein CEQ36_22925 ENOG4105C28 cystathionine CEQ36_22935 ENOG4105DS1 cytochrome b561 CEQ36_22940 ENOG4108YYC ycei family CEQ36_22945 ENOG4105DFD Na H antiporter CEQ36_22950 ENOG4105DDV Transcriptional regulator (LacI family CEQ36_22955 ENOG4105C5Y PTS System CEQ36_22960 ENOG4105CS2 ec 3.2.1.21 CEQ36_22970 ENOG4105NTW Transcriptional regulator CEQ36_23035 ENOG4105DFP Integrase CEQ36_23045 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CEQ36_23060 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) CEQ36_23065 ENOG41060IM Heme exporter protein CEQ36_23070 ENOG4105X3C heme exporter protein CEQ36_23075 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) CEQ36_23080 ENOG4105DA4 cytochrome c-type biogenesis protein CEQ36_23085 ENOG4107QX9 Thiol disulfide interChange protein CEQ36_23090 ENOG4105KWW Biogenesis protein CEQ36_23095 ENOG4105KWW Biogenesis protein CEQ36_23100 ENOG410903C (LipO)protein CEQ36_23105 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation CEQ36_23110 ENOG4105KZW UPF0381 protein CEQ36_23115 ENOG4105CHU acetyl-coa acetyltransferase CEQ36_23120 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CEQ36_23125 ENOG4108BY2 phosphohistidine phosphatase CEQ36_23130 ENOG4108DG9 Smr protein MutS2 CEQ36_23135 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) CEQ36_23140 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CEQ36_23145 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) CEQ36_23150 ENOG4105EJ9 Membrane CEQ36_23155 ENOG4108BPE -transporting atpase CEQ36_23160 ENOG4105MH2 YfcL protein CEQ36_23165 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) CEQ36_23170 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CEQ36_23175 ENOG4105BZU Histidine kinase CEQ36_23185 ENOG4105D6F Phosphatase CEQ36_23190 ENOG4105F4P )-transporter