locus-tag	class	description
OP861_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OP861_00010	COG0592	DNA-directed DNA polymerase activity
OP861_00020	COG0187	DNA topoisomerase II activity
OP861_00025	COG0561	phosphatase activity
OP861_00030	COG1447	Phosphotransferase system cellobiose-specific component IIA
OP861_00040	COG1940	carbohydrate kinase activity
OP861_00045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OP861_00055	COG2723	6-phospho-beta-galactosidase activity
OP861_00060	COG2188	Transcriptional regulator
OP861_00065	COG2423	ornithine cyclodeaminase activity
OP861_00070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OP861_00080	COG2186	Transcriptional regulator
OP861_00085	COG3734	2-keto-3-deoxy-galactonokinase
OP861_00090	COG0800	Aldolase
OP861_00095	COG4948	Mandelate Racemase Muconate Lactonizing
OP861_00100	COG2271	Major facilitator Superfamily
OP861_00105	COG0823	Involved in the tonB-independent uptake of proteins
OP861_00110	COG5645	(Lipo)protein
OP861_00130	COG3977	Valine--pyruvate aminotransferase
OP861_00135	COG0366	Alpha amylase catalytic
OP861_00155	COG2885	chlorophyll binding
OP861_00170	COG0456	acetyltransferase
OP861_00175	COG2818	Glycosylase
OP861_00185	COG0751	glycine-tRNA ligase activity
OP861_00195	COG2213	PTS system mannitol-specific
OP861_00195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP861_00200	COG0246	Mannitol dehydrogenase
OP861_00205	COG3722	fumarate hydratase activity
OP861_00215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OP861_00235	COG2258	MOSC domain
OP861_00240	COG0840	transmembrane signaling receptor activity
OP861_00245	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OP861_00250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OP861_00260	COG0437	4 iron, 4 sulfur cluster binding
OP861_00265	COG2864	formate dehydrogenase
OP861_00270	COG3058	Necessary for formate dehydrogenase activity
OP861_00275	COG1921	L-seryl-tRNASec selenium transferase activity
OP861_00280	COG3276	selenocysteine insertion sequence binding
OP861_00290	COG3550	peptidyl-serine autophosphorylation
OP861_00300	COG3274	enterobacterial common antigen metabolic process
OP861_00310	COG1335	isochorismatase
OP861_00320	COG3188	usher protein
OP861_00325	COG3121	Chaperone
OP861_00335	COG1070	Carbohydrate kinase
OP861_00340	COG2115	Belongs to the xylose isomerase family
OP861_00345	COG4213	ABC transporter substrate-binding protein
OP861_00355	COG4214	carbohydrate transport
OP861_00360	COG1609	Transcriptional regulator
OP861_00360	COG2207	Transcriptional regulator
OP861_00375	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
OP861_00380	COG2986	histidine ammonia-lyase
OP861_00400	COG1764	response to oxidative stress
OP861_00405	COG2194	sulfuric ester hydrolase activity
OP861_00410	COG2197	response regulator
OP861_00415	COG3851	Histidine kinase
OP861_00420	COG2271	Major facilitator Superfamily
OP861_00430	COG0747	negative chemotaxis
OP861_00435	COG0601	transmembrane transport
OP861_00440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OP861_00445	COG0444	Belongs to the ABC transporter superfamily
OP861_00450	COG4608	Belongs to the ABC transporter superfamily
OP861_00455	COG2194	sulfuric ester hydrolase activity
OP861_00475	COG1192	Involved in chromosome partitioning
OP861_00485	COG1215	transferase activity, transferring glycosyl groups
OP861_00490	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
OP861_00495	COG0457	Tetratricopeptide repeat
OP861_00495	COG3118	belongs to the thioredoxin family
OP861_00500	COG2199	diguanylate cyclase activity
OP861_00500	COG2200	EAL domain
OP861_00510	COG3121	Chaperone
OP861_00515	COG3188	usher protein
OP861_00525	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OP861_00540	COG1301	dicarboxylic acid transport
OP861_00545	COG0612	Peptidase, M16
OP861_00550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OP861_00555	COG1942	4-Oxalocrotonate Tautomerase
OP861_00560	COG2200	EAL domain
OP861_00565	COG2982	Protein involved in outer membrane biogenesis
OP861_00570	COG2134	cdp-diacylglycerol pyrophosphatase
OP861_00575	COG1295	ribonuclease BN
OP861_00580	COG1396	sequence-specific DNA binding
OP861_00590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OP861_00595	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OP861_00605	COG0742	ribosomal rna small subunit methyltransferase
OP861_00620	COG0589	response to stress
OP861_00630	COG0306	phosphate transporter
OP861_00635	COG2081	HI0933 family
OP861_00660	COG0583	DNA-binding transcription factor activity
OP861_00665	COG2814	Major facilitator Superfamily
OP861_00680	COG3718	enzyme involved in inositol metabolism
OP861_00695	COG3962	Belongs to the TPP enzyme family
OP861_00700	COG0673	inositol 2-dehydrogenase activity
OP861_00705	COG1082	Xylose isomerase domain protein TIM barrel
OP861_00710	COG1247	-acetyltransferase
OP861_00715	COG1741	Belongs to the pirin family
OP861_00720	COG1609	Transcriptional regulator
OP861_00725	COG2610	gluconate transmembrane transporter activity
OP861_00730	COG3265	gluconokinase activity
OP861_00735	COG2095	MarC family integral membrane protein
OP861_00740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OP861_00760	COG3275	phosphorelay sensor kinase activity
OP861_00765	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OP861_00770	COG1523	belongs to the glycosyl hydrolase 13 family
OP861_00775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OP861_00780	COG0297	glycogen (starch) synthase activity
OP861_00785	COG0058	SHG alpha-glucan phosphorylase activity
OP861_00790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OP861_00795	COG1349	DNA-binding transcription factor activity
OP861_00800	COG0705	Rhomboid family
OP861_00810	COG2909	trisaccharide binding
OP861_00815	COG0058	SHG alpha-glucan phosphorylase activity
OP861_00820	COG1640	4-alpha-glucanotransferase
OP861_00825	COG0316	Belongs to the HesB IscA family
OP861_00825	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
OP861_00835	COG0596	Alpha beta hydrolase
OP861_00855	COG1918	ferrous iron import across plasma membrane
OP861_00860	COG2183	response to ionizing radiation
OP861_00865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OP861_00890	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OP861_00895	COG1011	Hydrolase
OP861_00905	COG0494	nUDIX hydrolase
OP861_00910	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OP861_00935	COG4796	Type ii and iii secretion system protein
OP861_00940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OP861_00960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OP861_00970	COG0180	Tryptophanyl-tRNA synthetase
OP861_00975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OP861_00975	COG1648	precorrin-2 dehydrogenase activity
OP861_00990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OP861_00995	COG0402	S-adenosylhomocysteine deaminase activity
OP861_01000	COG0738	Major facilitator superfamily
OP861_01015	COG1609	Transcriptional regulator
OP861_01020	COG1486	melibiose metabolic process
OP861_01025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OP861_01030	COG0433	COG0433 Predicted ATPase
OP861_01045	COG1289	transmembrane transporter activity
OP861_01055	COG1765	OsmC-like protein
OP861_01060	COG3954	Phosphoribulokinase
OP861_01065	COG3089	Belongs to the UPF0270 family
OP861_01070	COG0429	hydrolase of the alpha beta-hydrolase fold
OP861_01085	COG4521	taurine ABC transporter
OP861_01095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OP861_01100	COG2175	clavaminate synthase activity
OP861_01110	COG1216	Glycosyl transferase, family 2
OP861_01115	COG0488	(ABC) transporter
OP861_01120	COG2249	NAD(P)H dehydrogenase (quinone) activity
OP861_01130	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
OP861_01135	COG1047	Peptidyl-prolyl cis-trans
OP861_01145	COG0545	Peptidyl-prolyl cis-trans isomerase
OP861_01150	COG2964	Protein conserved in bacteria
OP861_01155	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OP861_01160	COG2923	Belongs to the DsrF TusC family
OP861_01165	COG2168	tRNA wobble position uridine thiolation
OP861_01170	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OP861_01175	COG0049	tRNA binding
OP861_01185	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OP861_01200	COG0051	transcription antitermination factor activity, RNA binding
OP861_01215	COG0089	rRNA binding
OP861_01225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OP861_01235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OP861_01240	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OP861_01245	COG0255	Belongs to the universal ribosomal protein uL29 family
OP861_01250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OP861_01255	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OP861_01260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OP861_01270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OP861_01275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OP861_01280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OP861_01285	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OP861_01290	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OP861_01295	COG1841	ribosomal large subunit assembly
OP861_01300	COG0200	Binds to the 23S rRNA
OP861_01305	COG0201	protein transport
OP861_01310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OP861_01315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OP861_01320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OP861_01325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OP861_01335	COG0203	ribosomal protein L17
OP861_01345	COG0789	Transcriptional regulator
OP861_01350	COG3036	rescue of stalled ribosome
OP861_01355	COG1970	mechanosensitive ion channel activity
OP861_01360	COG0569	domain protein
OP861_01365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OP861_01365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OP861_01370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OP861_01375	COG0242	peptide deformylase activity
OP861_01380	COG0758	DNA mediated transformation
OP861_01390	COG0551	DNA topoisomerase type I activity
OP861_01395	COG0009	L-threonylcarbamoyladenylate synthase
OP861_01400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OP861_01405	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OP861_01450	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
OP861_01455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OP861_01460	COG2224	Isocitrate lyase
OP861_01465	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
OP861_01470	COG0183	Belongs to the thiolase family
OP861_01475	COG2031	fatty acid transporter
OP861_01480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OP861_01485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
OP861_01490	COG2204	response regulator
OP861_01495	COG3852	Histidine kinase
OP861_01500	COG1414	Transcriptional regulator
OP861_01525	COG0527	aspartate kinase activity
OP861_01535	COG3223	Belongs to the PsiE family
OP861_01540	COG3833	ABC-type maltose transport systems, permease component
OP861_01545	COG1175	transmembrane transport
OP861_01565	COG4580	involved in the transport of maltose and maltodextrins
OP861_01580	COG3161	chorismate lyase activity
OP861_01590	COG2937	Belongs to the GPAT DAPAT family
OP861_01595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OP861_01600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OP861_01605	COG3237	CsbD-like
OP861_01610	COG0735	belongs to the Fur family
OP861_01615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OP861_01625	COG0604	alcohol dehydrogenase
OP861_01640	COG1448	Aminotransferase
OP861_01645	COG2315	Protein conserved in bacteria
OP861_01650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OP861_01655	COG0629	single-stranded DNA binding
OP861_01660	COG3550	peptidyl-serine autophosphorylation
OP861_01675	COG2252	PERMEase
OP861_01680	COG0025	NhaP-type Na H and K H
OP861_01685	COG0583	DNA-binding transcription factor activity
OP861_01690	COG1380	Effector of murein hydrolase LrgA
OP861_01700	COG1126	abc transporter atp-binding protein
OP861_01705	COG0765	amino acid transport
OP861_01710	COG4597	amino acid ABC transporter
OP861_01715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP861_01725	COG1560	Kdo2-lipid A biosynthetic process
OP861_01735	COG1129	ABC transporter
OP861_01740	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_01750	COG1069	ribulokinase activity
OP861_01760	COG0471	metal ion transport
OP861_01765	COG1278	Cold shock
OP861_01770	COG1278	Cold shock
OP861_01775	COG3133	Outer membrane lipoprotein
OP861_01780	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OP861_01785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OP861_01790	COG2264	protein methyltransferase activity
OP861_01795	COG4145	pantothenate transmembrane transporter activity
OP861_01800	COG3924	membrane
OP861_01805	COG0439	Biotin carboxylase
OP861_01810	COG0511	ligase activity, forming carbon-carbon bonds
OP861_01820	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
OP861_01830	COG0604	alcohol dehydrogenase
OP861_01835	COG2200	EAL domain
OP861_01835	COG2199	diguanylate cyclase activity
OP861_01840	COG1077	Cell shape determining protein MreB Mrl
OP861_01845	COG1792	Involved in formation and maintenance of cell shape
OP861_01850	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OP861_01855	COG0424	maF-like protein
OP861_01860	COG1530	ribonuclease E activity
OP861_01865	COG3164	Protein of unknown function
OP861_01870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OP861_01875	COG0312	modulator of DNA gyrase
OP861_01920	COG0583	DNA-binding transcription factor activity
OP861_01930	COG1566	PFAM secretion protein HlyD family protein
OP861_01935	COG1289	transmembrane transporter activity
OP861_01940	COG1012	belongs to the aldehyde dehydrogenase family
OP861_01950	COG2732	(Barnase) inhibitor
OP861_01955	COG3028	Belongs to the UPF0307 family
OP861_01960	COG0312	modulator of DNA gyrase
OP861_01965	COG3783	Cytochrome b(562)
OP861_01970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OP861_02000	COG3964	amidohydrolase
OP861_02015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP861_02015	COG3711	transcriptional antiterminator
OP861_02020	COG3093	addiction module antidote protein HigA
OP861_02030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OP861_02040	COG1263	PTS System
OP861_02040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP861_02045	COG0366	Alpha amylase catalytic
OP861_02065	COG2308	Evidence 4 Homologs of previously reported genes of
OP861_02075	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
OP861_02080	COG0540	Belongs to the ATCase OTCase family
OP861_02090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OP861_02095	COG2271	Major facilitator Superfamily
OP861_02100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP861_02105	COG1660	Displays ATPase and GTPase activities
OP861_02120	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
OP861_02125	COG1137	ATPase activity
OP861_02130	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OP861_02135	COG3117	lipopolysaccharide transmembrane transporter activity
OP861_02140	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OP861_02145	COG0517	IMP dehydrogenase activity
OP861_02145	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OP861_02150	COG0530	calcium, potassium:sodium antiporter activity
OP861_02155	COG1127	ABC transporter
OP861_02160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OP861_02165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OP861_02170	COG2854	intermembrane phospholipid transfer
OP861_02175	COG3113	response to antibiotic
OP861_02180	COG5007	Belongs to the BolA IbaG family
OP861_02185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OP861_02190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OP861_02195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OP861_02200	COG3105	Protein conserved in bacteria
OP861_02205	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OP861_02210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OP861_02215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OP861_02220	COG0625	glutathione transferase activity
OP861_02225	COG2969	positive regulation of protein catabolic process
OP861_02235	COG0493	'glutamate synthase
OP861_02240	COG0069	glutamate synthase activity
OP861_02240	COG0067	glutamate synthase
OP861_02240	COG0070	glutamate synthase
OP861_02245	COG1242	4 iron, 4 sulfur cluster binding
OP861_02250	COG0784	Response regulator, receiver
OP861_02250	COG2198	Histidine kinase
OP861_02250	COG5002	protein histidine kinase activity
OP861_02255	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
OP861_02260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OP861_02265	COG2823	Periplasmic or secreted lipoprotein
OP861_02270	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OP861_02275	COG0792	nuclease activity
OP861_02285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OP861_02300	COG1064	alcohol dehydrogenase
OP861_02305	COG1741	Belongs to the pirin family
OP861_02310	COG0583	DNA-binding transcription factor activity
OP861_02315	COG0435	Glutathione S-transferase
OP861_02320	COG2259	Doxx family
OP861_02330	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
OP861_02335	COG4575	ribosome binding
OP861_02350	COG0586	Pfam SNARE associated Golgi protein
OP861_02365	COG2271	Major facilitator Superfamily
OP861_02375	COG0246	Mannitol dehydrogenase
OP861_02380	COG2721	sulfolactate sulfo-lyase activity
OP861_02390	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
OP861_02395	COG0861	Integral membrane protein TerC family
OP861_02400	COG0673	inositol 2-dehydrogenase activity
OP861_02405	COG1451	nucleotide metabolic process
OP861_02410	COG3468	outer membrane autotransporter barrel domain protein
OP861_02415	COG2813	Specifically methylates the guanine in position
OP861_02420	COG0446	pyridine nucleotide-disulphide oxidoreductase
OP861_02420	COG1902	pentaerythritol trinitrate reductase activity
OP861_02430	COG2378	regulation of single-species biofilm formation
OP861_02440	COG3247	response to pH
OP861_02445	COG2814	Major facilitator Superfamily
OP861_02480	COG0358	DNA primase activity
OP861_02485	COG0828	Belongs to the bacterial ribosomal protein bS21 family
OP861_02490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OP861_02495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OP861_02500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OP861_02510	COG0617	tRNA 3'-terminal CCA addition
OP861_02515	COG4991	sh3 domain protein
OP861_02520	COG3025	triphosphatase activity
OP861_02525	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OP861_02530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
OP861_02530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
OP861_02535	COG0531	amino acid
OP861_02545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OP861_02550	COG3384	dioxygenase
OP861_02555	COG0754	glutathionylspermidine amidase activity
OP861_02560	COG5463	Belongs to the UPF0441 family
OP861_02565	COG1538	Outer membrane efflux protein
OP861_02570	COG0494	nUDIX hydrolase
OP861_02575	COG3151	Protein conserved in bacteria
OP861_02580	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OP861_02585	COG3150	esterase
OP861_02595	COG0583	DNA-binding transcription factor activity
OP861_02600	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OP861_02605	COG2249	NAD(P)H dehydrogenase (quinone) activity
OP861_02620	COG1653	transport
OP861_02635	COG3716	PTS system mannose fructose sorbose family IID component
OP861_02640	COG3715	PTS system
OP861_02645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP861_02650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OP861_02655	COG0204	Acyl-transferase
OP861_02660	COG2132	Multicopper oxidase
OP861_02670	COG0656	L-ascorbic acid biosynthetic process
OP861_02675	COG1979	alcohol dehydrogenase
OP861_02680	COG2207	Transcriptional regulator
OP861_02685	COG0586	Pfam SNARE associated Golgi protein
OP861_02690	COG0626	cystathionine gamma-synthase activity
OP861_02700	COG0848	biopolymer transport protein
OP861_02750	COG4964	Belongs to the GSP D family
OP861_02780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OP861_02785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP861_02810	COG1120	ATPase activity
OP861_02815	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OP861_02820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OP861_02825	COG4592	Periplasmic binding protein
OP861_02830	COG0840	transmembrane signaling receptor activity
OP861_02850	COG3133	Outer membrane lipoprotein
OP861_02855	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
OP861_02860	COG0437	4 iron, 4 sulfur cluster binding
OP861_02865	COG5557	Pfam Polysulphide reductase, NrfD
OP861_02870	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
OP861_02875	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
OP861_02880	COG1773	rubredoxin
OP861_02890	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OP861_02890	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OP861_02895	COG0298	carbon dioxide binding
OP861_02900	COG0409	Hydrogenase expression formation protein
OP861_02905	COG0309	Hydrogenase expression formation protein (HypE)
OP861_02910	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
OP861_02915	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
OP861_02920	COG5001	Diguanylate cyclase
OP861_02930	COG4303	Ethanolamine ammonia lyase large subunit
OP861_02935	COG4302	ethanolamine ammonia-lyase activity
OP861_02940	COG0477	Major facilitator Superfamily
OP861_02960	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
OP861_02965	COG2195	Cleaves the N-terminal amino acid of tripeptides
OP861_02970	COG1283	sodium-dependent phosphate transmembrane transporter activity
OP861_02980	COG4607	ABC-type enterochelin transport system periplasmic component
OP861_02990	COG4605	iron ion homeostasis
OP861_02995	COG4604	ABC transporter, ATP-binding protein
OP861_03055	COG1289	transmembrane transporter activity
OP861_03070	COG0081	regulation of translation
OP861_03095	COG3121	Chaperone
OP861_03100	COG3188	usher protein
OP861_03130	COG2040	homocysteine
OP861_03135	COG0833	amino acid
OP861_03175	COG3038	cytochrome b561
OP861_03180	COG0789	Transcriptional regulator
OP861_03190	COG0300	oxidoreductase activity
OP861_03205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OP861_03230	COG3447	MASE1 domain protein
OP861_03230	COG5001	Diguanylate cyclase
OP861_03230	COG5002	protein histidine kinase activity
OP861_03235	COG1105	Belongs to the carbohydrate kinase PfkB family
OP861_03260	COG2188	Transcriptional regulator
OP861_03265	COG2771	luxR family
OP861_03270	COG3916	Acyl-homoserine-lactone synthase
OP861_03275	COG4810	utilization protein
OP861_03285	COG4766	ethanolamine catabolic process
OP861_03300	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
OP861_03305	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
OP861_03335	COG4303	Ethanolamine ammonia lyase large subunit
OP861_03365	COG2207	Transcriptional regulator
OP861_03420	COG1982	Orn Lys Arg decarboxylase major
OP861_03430	COG0741	lytic transglycosylase activity
OP861_03440	COG1194	a g-specific adenine glycosylase
OP861_03445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OP861_03450	COG3171	Protein conserved in bacteria
OP861_03465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OP861_03470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OP861_03475	COG1872	DUF167
OP861_03480	COG0762	integral membrane protein
OP861_03485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OP861_03490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OP861_03495	COG2805	Type II/IV secretion system protein
OP861_03505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OP861_03510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OP861_03515	COG1678	Uncharacterized ACR, COG1678
OP861_03520	COG0189	ligase activity
OP861_03525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OP861_03530	COG2356	endonuclease I
OP861_03535	COG3091	SprT-like family
OP861_03540	COG0640	Transcriptional regulator
OP861_03555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OP861_03560	COG1166	arginine decarboxylase activity
OP861_03570	COG0501	Belongs to the peptidase M48B family
OP861_03575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OP861_03580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OP861_03585	COG0126	phosphoglycerate kinase activity
OP861_03590	COG0191	fructose-bisphosphate aldolase activity
OP861_03600	COG1279	arginine transmembrane transporter activity
OP861_03610	COG0583	DNA-binding transcription factor activity
OP861_03615	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
OP861_03620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OP861_03625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OP861_03635	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
OP861_03640	COG3079	Belongs to the UPF0149 family
OP861_03645	COG0006	proline dipeptidase activity
OP861_03650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OP861_03655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OP861_03660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OP861_03665	COG0509	glycine decarboxylation via glycine cleavage system
OP861_03670	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OP861_03670	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OP861_03675	COG1028	Short-chain dehydrogenase reductase Sdr
OP861_03685	COG1272	protein, Hemolysin III
OP861_03690	COG0354	folic acid binding
OP861_03705	COG0745	RESPONSE REGULATOR receiver
OP861_03710	COG2205	protein histidine kinase activity
OP861_03715	COG4452	Inner membrane protein CreD
OP861_03720	COG0716	FMN binding
OP861_03725	COG4974	Belongs to the 'phage' integrase family
OP861_03730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OP861_03735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OP861_03755	COG0582	viral genome integration into host DNA
OP861_03765	COG3177	Filamentation induced by cAMP protein fic
OP861_03820	COG3706	GGDEF domain
OP861_03825	COG1522	sequence-specific DNA binding
OP861_03840	COG2271	Major facilitator Superfamily
OP861_03850	COG0484	heat shock protein binding
OP861_03860	COG1028	Short-chain dehydrogenase reductase Sdr
OP861_03865	COG1733	regulation of RNA biosynthetic process
OP861_03870	COG0288	reversible hydration of carbon dioxide
OP861_03890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OP861_03905	COG2165	general secretion pathway protein
OP861_03910	COG4795	General secretion pathway protein
OP861_03930	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
OP861_03965	COG0583	DNA-binding transcription factor activity
OP861_03970	COG0583	DNA-binding transcription factor activity
OP861_03980	COG1609	Transcriptional regulator
OP861_03985	COG1609	Transcriptional regulator
OP861_03995	COG0204	Acyl-transferase
OP861_03995	COG0318	PFAM AMP-dependent synthetase and ligase
OP861_04000	COG0477	Major facilitator Superfamily
OP861_04005	COG0667	Aldo Keto reductase
OP861_04015	COG0861	Integral membrane protein TerC family
OP861_04020	COG3066	DNA modification
OP861_04035	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OP861_04045	COG2165	general secretion pathway protein
OP861_04050	COG4795	General secretion pathway protein
OP861_04065	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OP861_04070	COG1025	Belongs to the peptidase M16 family
OP861_04075	COG1074	ATP-dependent DNA helicase activity
OP861_04080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OP861_04085	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
OP861_04085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OP861_04090	COG0860	N-Acetylmuramoyl-L-alanine amidase
OP861_04110	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
OP861_04115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OP861_04120	COG2166	iron-sulfur cluster assembly
OP861_04125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OP861_04135	COG0583	DNA-binding transcription factor activity
OP861_04140	COG2363	Small membrane protein
OP861_04145	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
OP861_04150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OP861_04155	COG1611	Belongs to the LOG family
OP861_04160	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OP861_04160	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OP861_04170	COG3098	single-species biofilm formation
OP861_04175	COG0564	pseudouridine synthase activity
OP861_04190	COG2171	N-acyltransferase activity
OP861_04195	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
OP861_04205	COG0052	Belongs to the universal ribosomal protein uS2 family
OP861_04210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OP861_04215	COG0528	UMP kinase activity
OP861_04220	COG0233	cytoplasmic translational termination
OP861_04225	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OP861_04235	COG0575	Belongs to the CDS family
OP861_04240	COG0750	zinc metalloprotease
OP861_04250	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
OP861_04255	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OP861_04260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OP861_04265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OP861_04275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OP861_04285	COG0825	malonyl-CoA metabolic process
OP861_04290	COG1982	Orn Lys Arg decarboxylase major
OP861_04295	COG0346	lactoylglutathione lyase activity
OP861_04310	COG4568	rho-dependent transcription termination
OP861_04320	COG4681	YaeQ
OP861_04330	COG3015	lipoprotein NlpE involved in copper resistance
OP861_04335	COG0442	prolyl-tRNA aminoacylation
OP861_04340	COG1720	tRNA m6t6A37 methyltransferase activity
OP861_04350	COG1464	Belongs to the NlpA lipoprotein family
OP861_04355	COG2011	ABC-type metal ion transport system permease component
OP861_04365	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OP861_04420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OP861_04435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OP861_04465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OP861_04475	COG1028	Short-chain dehydrogenase reductase Sdr
OP861_04485	COG0583	DNA-binding transcription factor activity
OP861_04490	COG2814	Major facilitator Superfamily
OP861_04495	COG3021	interspecies interaction between organisms
OP861_04500	COG0741	lytic transglycosylase activity
OP861_04500	COG1388	LysM domain
OP861_04505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OP861_04510	COG2226	methyltransferase
OP861_04550	COG2113	Glycine betaine
OP861_04555	COG4176	ABC-type proline glycine betaine transport system permease component
OP861_04560	COG4175	Glycine betaine
OP861_04565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OP861_04575	COG1780	Probably involved in ribonucleotide reductase function
OP861_04580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OP861_04585	COG4575	ribosome binding
OP861_04600	COG3708	Transcriptional regulator
OP861_04600	COG2207	Transcriptional regulator
OP861_04620	COG1278	Cold shock
OP861_04650	COG0601	transmembrane transport
OP861_04655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OP861_04665	COG1124	(ABC) transporter
OP861_04670	COG0831	urea catabolic process
OP861_04680	COG0804	urea catabolic process
OP861_04685	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
OP861_04690	COG0830	nickel cation binding
OP861_04695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OP861_04705	COG4413	Urea transporter
OP861_04710	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
OP861_04720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OP861_04735	COG0667	Aldo Keto reductase
OP861_04740	COG2133	pyrroloquinoline quinone binding
OP861_04745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OP861_04750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OP861_04755	COG2723	6-phospho-beta-galactosidase activity
OP861_04760	COG1447	Phosphotransferase system cellobiose-specific component IIA
OP861_04765	COG1917	Cupin 2, conserved barrel domain protein
OP861_04765	COG2169	Transcriptional regulator
OP861_04770	COG3394	polysaccharide catabolic process
OP861_04790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OP861_04795	COG2867	negative regulation of translational initiation
OP861_04805	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OP861_04810	COG0497	DNA recombination
OP861_04815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OP861_04820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OP861_04825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OP861_04830	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
OP861_04845	COG0513	Belongs to the DEAD box helicase family
OP861_04850	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
OP861_04855	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
OP861_04865	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
OP861_04870	COG3026	antisigma factor binding
OP861_04875	COG3086	response to oxidative stress
OP861_04885	COG0481	GTPase activity
OP861_04900	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OP861_04905	COG1381	Involved in DNA repair and RecF pathway recombination
OP861_04910	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OP861_04915	COG0736	holo-[acyl-carrier-protein] synthase activity
OP861_04920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP861_04925	COG1737	Transcriptional regulator
OP861_04940	COG0560	Phosphoserine phosphatase
OP861_04955	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
OP861_04970	COG2205	protein histidine kinase activity
OP861_04975	COG3170	Tfp pilus assembly protein FimV
OP861_04980	COG2204	response regulator
OP861_04985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OP861_04985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OP861_04990	COG0347	Belongs to the P(II) protein family
OP861_05005	COG1735	metal-dependent hydrolase with the TIM-barrel fold
OP861_05010	COG3457	Alanine racemase
OP861_05020	COG2188	Transcriptional regulator
OP861_05025	COG1017	nitric oxide dioxygenase activity
OP861_05025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OP861_05035	COG2814	Major facilitator Superfamily
OP861_05040	COG3711	transcriptional antiterminator
OP861_05045	COG3683	transport system, periplasmic component
OP861_05050	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
OP861_05060	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
OP861_05065	COG1959	2 iron, 2 sulfur cluster binding
OP861_05075	COG0822	iron-sulfur transferase activity
OP861_05085	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
OP861_05090	COG0443	Heat shock 70 kDa protein
OP861_05095	COG0633	Ferredoxin
OP861_05100	COG2975	iron-sulfur cluster assembly
OP861_05115	COG3468	outer membrane autotransporter barrel domain protein
OP861_05120	COG2373	Large extracellular alpha-helical protein
OP861_05125	COG4953	penicillin-binding protein 1C
OP861_05140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
OP861_05165	COG2976	Protein conserved in bacteria
OP861_05170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OP861_05185	COG1645	bacterial-type flagellum-dependent swarming motility
OP861_05190	COG1570	exodeoxyribonuclease VII activity
OP861_05195	COG0517	IMP dehydrogenase activity
OP861_05195	COG0516	GMP reductase activity
OP861_05200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OP861_05200	COG0519	Catalyzes the synthesis of GMP from XMP
OP861_05220	COG0351	phosphomethylpyrimidine kinase
OP861_05240	COG1349	DNA-binding transcription factor activity
OP861_05245	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP861_05250	COG1028	Short-chain dehydrogenase reductase Sdr
OP861_05265	COG3730	PTS system glucitol sorbitol-specific
OP861_05270	COG1597	lipid kinase activity
OP861_05275	COG0826	peptidase U32
OP861_05290	COG3422	double-strand break repair
OP861_05295	COG0745	RESPONSE REGULATOR receiver
OP861_05300	COG2205	protein histidine kinase activity
OP861_05305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OP861_05315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP861_05320	COG0443	Heat shock 70 kDa protein
OP861_05325	COG3447	MASE1 domain protein
OP861_05325	COG5002	protein histidine kinase activity
OP861_05325	COG5001	Diguanylate cyclase
OP861_05330	COG2239	Acts as a magnesium transporter
OP861_05340	COG0248	Ppx GppA phosphatase
OP861_05345	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OP861_05350	COG0573	inorganic phosphate transmembrane transporter activity
OP861_05355	COG0581	inorganic phosphate transmembrane transporter activity
OP861_05370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OP861_05375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OP861_05390	COG2233	PERMEase
OP861_05395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OP861_05400	COG1393	Belongs to the ArsC family
OP861_05405	COG4783	chaperone-mediated protein folding
OP861_05410	COG0628	permease
OP861_05415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OP861_05420	COG2716	regulation of RNA biosynthetic process
OP861_05425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OP861_05430	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
OP861_05440	COG2321	neutral zinc metallopeptidase
OP861_05450	COG1444	tRNA N-acetyltransferase activity
OP861_05465	COG0400	carboxylic ester hydrolase activity
OP861_05475	COG1876	peptidase activity
OP861_05480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OP861_05485	COG1393	Belongs to the ArsC family
OP861_05495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OP861_05505	COG2197	response regulator
OP861_05510	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP861_05510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP861_05515	COG3062	negative regulation of establishment of protein localization
OP861_05520	COG0243	molybdopterin cofactor binding
OP861_05525	COG3043	anaerobic respiration
OP861_05530	COG3005	denitrification pathway
OP861_05545	COG0494	nUDIX hydrolase
OP861_05555	COG1671	Belongs to the UPF0178 family
OP861_05560	COG0408	coproporphyrinogen oxidase activity
OP861_05565	COG0456	acetyltransferase
OP861_05570	COG3111	PFAM Bacterial OB fold (BOF) protein
OP861_05580	COG2837	iron assimilation
OP861_05585	COG4150	thiosulfate binding
OP861_05590	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OP861_05595	COG4208	sulfate ABC transporter
OP861_05605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OP861_05635	COG1215	transferase activity, transferring glycosyl groups
OP861_05635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
OP861_05665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP861_05670	COG0745	RESPONSE REGULATOR receiver
OP861_05675	COG2205	protein histidine kinase activity
OP861_05690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP861_05700	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
OP861_05710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OP861_05715	COG3530	Putative quorum-sensing-regulated virulence factor
OP861_05740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OP861_05780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OP861_05785	COG1914	H( )-stimulated, divalent metal cation uptake system
OP861_05795	COG0667	Aldo Keto reductase
OP861_05810	COG0837	glucose binding
OP861_05815	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
OP861_05825	COG2223	nitrite transmembrane transporter activity
OP861_05830	COG3279	Response regulator of the LytR AlgR family
OP861_05835	COG3275	phosphorelay sensor kinase activity
OP861_05850	COG0436	Aminotransferase
OP861_05860	COG1598	PFAM Uncharacterised protein family UPF0150
OP861_05870	COG3381	protein complex oligomerization
OP861_05875	COG3302	dmso reductase anchor subunit
OP861_05880	COG0437	4 iron, 4 sulfur cluster binding
OP861_05885	COG0243	molybdopterin cofactor binding
OP861_05900	COG2723	6-phospho-beta-galactosidase activity
OP861_05945	COG2951	lytic endotransglycosylase activity
OP861_05950	COG0531	amino acid
OP861_05970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OP861_05975	COG1127	ABC transporter
OP861_05995	COG0626	cystathionine gamma-synthase activity
OP861_06005	COG3038	cytochrome b561
OP861_06010	COG2353	YceI-like domain
OP861_06015	COG1757	Na H antiporter
OP861_06020	COG1609	Transcriptional regulator
OP861_06025	COG1263	PTS System
OP861_06025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP861_06030	COG2723	6-phospho-beta-galactosidase activity
OP861_06040	COG1695	Transcriptional regulator
OP861_06075	COG0582	viral genome integration into host DNA
OP861_06085	COG2824	Alkylphosphonate utilization operon protein PhnA
OP861_06095	COG2116	formate transmembrane transporter activity
OP861_06105	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OP861_06110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OP861_06115	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OP861_06120	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OP861_06125	COG1138	Cytochrome C-type biogenesis protein
OP861_06130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OP861_06135	COG4235	cytochrome complex assembly
OP861_06135	COG3088	subunit of a heme lyase
OP861_06140	COG4235	cytochrome complex assembly
OP861_06140	COG3088	subunit of a heme lyase
OP861_06155	COG3691	Protein conserved in bacteria
OP861_06160	COG0183	Belongs to the thiolase family
OP861_06165	COG1250	3-hydroxyacyl-CoA dehydrogenase
OP861_06165	COG1024	Enoyl-CoA hydratase
OP861_06170	COG2062	phosphohistidine phosphatase, SixA
OP861_06175	COG2840	Smr protein MutS2
OP861_06180	COG2890	protein-(glutamine-N5) methyltransferase activity
OP861_06185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OP861_06190	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
OP861_06195	COG0730	response to heat
OP861_06200	COG3101	peptidyl-lysine hydroxylation
OP861_06210	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
OP861_06210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OP861_06215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OP861_06225	COG1794	racemase activity, acting on amino acids and derivatives
OP861_06235	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
OP861_06260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OP861_06265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OP861_06290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OP861_06300	COG0586	Pfam SNARE associated Golgi protein
OP861_06310	COG0285	dihydrofolate synthase activity
OP861_06315	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
OP861_06320	COG1286	toxin biosynthetic process
OP861_06325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
OP861_06335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP861_06340	COG4215	(ABC) transporter
OP861_06350	COG4598	ABC transporter
OP861_06355	COG1090	epimerase
OP861_06365	COG0622	Phosphoesterase
OP861_06370	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
OP861_06375	COG3037	sugar-specific permease SgaT UlaA
OP861_06385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP861_06390	COG1609	Transcriptional regulator
OP861_06395	COG0280	phosphate acetyltransferase
OP861_06395	COG0857	belongs to the CobB CobQ family
OP861_06405	COG3092	negative regulation of chromosome organization
OP861_06415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OP861_06420	COG0490	domain, Protein
OP861_06420	COG0471	metal ion transport
OP861_06425	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
OP861_06435	COG0436	Aminotransferase
OP861_06440	COG0583	DNA-binding transcription factor activity
OP861_06450	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP861_06455	COG0649	NAD binding
OP861_06455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP861_06470	COG1034	ATP synthesis coupled electron transport
OP861_06475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
OP861_06480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP861_06485	COG0839	Belongs to the complex I subunit 6 family
OP861_06490	COG0713	ATP synthesis coupled electron transport
OP861_06495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OP861_06500	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP861_06505	COG1007	ATP synthesis coupled electron transport
OP861_06525	COG3265	gluconokinase activity
OP861_06530	COG1028	Short-chain dehydrogenase reductase Sdr
OP861_06535	COG1609	Transcriptional regulator
OP861_06540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OP861_06550	COG4702	Belongs to the UPF0303 family
OP861_06555	COG0129	dihydroxy-acid dehydratase activity
OP861_06560	COG4575	ribosome binding
OP861_06565	COG1169	isochorismate synthase
OP861_06570	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OP861_06580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OP861_06585	COG1441	menaquinone biosynthetic process
OP861_06615	COG0814	amino acid
OP861_06645	COG4574	serine-type endopeptidase inhibitor activity
OP861_06650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OP861_06660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OP861_06665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OP861_06675	COG0784	Response regulator, receiver
OP861_06675	COG2205	protein histidine kinase activity
OP861_06685	COG2198	Histidine kinase
OP861_06685	COG0642	Histidine kinase
OP861_06690	COG2223	nitrite transmembrane transporter activity
OP861_06695	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
OP861_06705	COG1414	Transcriptional regulator
OP861_06710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OP861_06715	COG2721	sulfolactate sulfo-lyase activity
OP861_06720	COG2271	Major facilitator Superfamily
OP861_06725	COG0371	Dehydrogenase
OP861_06735	COG1072	(Pantothenic acid kinase))
OP861_06745	COG1494	fructose-1,6-bisphosphatase
OP861_06750	COG1063	alcohol dehydrogenase
OP861_06755	COG2213	PTS system mannitol-specific
OP861_06760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP861_06765	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OP861_06770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OP861_06775	COG1301	dicarboxylic acid transport
OP861_06785	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OP861_06795	COG0583	DNA-binding transcription factor activity
OP861_06850	COG3188	usher protein
OP861_06855	COG3121	Chaperone
OP861_06880	COG0745	RESPONSE REGULATOR receiver
OP861_06895	COG1301	dicarboxylic acid transport
OP861_06910	COG3799	methylaspartate ammonia-lyase activity
OP861_06915	COG4865	methylaspartate mutase activity
OP861_06925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OP861_06935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OP861_06935	COG1648	precorrin-2 dehydrogenase activity
OP861_06940	COG0583	DNA-binding transcription factor activity
OP861_06945	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
OP861_06945	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
OP861_06960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OP861_07005	COG1263	PTS System
OP861_07005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP861_07005	COG2190	(PTS) system
OP861_07010	COG2723	6-phospho-beta-galactosidase activity
OP861_07015	COG3338	carbonate dehydratase activity
OP861_07035	COG3082	Protein of unknown function (DUF1414)
OP861_07040	COG3081	Nucleoid-associated protein
OP861_07050	COG1061	Type III restriction enzyme res subunit
OP861_07055	COG1187	pseudouridine synthase activity
OP861_07060	COG2814	Major facilitator Superfamily
OP861_07075	COG4172	Belongs to the ABC transporter superfamily
OP861_07080	COG4239	(ABC) transporter, permease
OP861_07085	COG4174	ABC transporter (Permease)
OP861_07090	COG4166	transmembrane transport
OP861_07095	COG2200	EAL domain
OP861_07100	COG0791	NLP P60 protein
OP861_07105	COG0671	phosphoesterase, PA-phosphatase related
OP861_07110	COG0523	cobalamin synthesis protein
OP861_07120	COG2186	Transcriptional regulator
OP861_07125	COG0246	Mannitol dehydrogenase
OP861_07135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OP861_07155	COG2222	sugar isomerase
OP861_07160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OP861_07165	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP861_07170	COG3716	PTS system mannose fructose sorbose family IID component
OP861_07180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP861_07190	COG1349	DNA-binding transcription factor activity
OP861_07200	COG3005	denitrification pathway
OP861_07215	COG1105	Belongs to the carbohydrate kinase PfkB family
OP861_07220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OP861_07220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OP861_07220	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
OP861_07225	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
OP861_07230	COG2855	membrane
OP861_07240	COG0583	DNA-binding transcription factor activity
OP861_07245	COG0833	amino acid
OP861_07250	COG4771	TonB-dependent receptor
OP861_07255	COG0625	glutathione transferase activity
OP861_07280	COG2011	ABC-type metal ion transport system permease component
OP861_07285	COG0626	cystathionine gamma-synthase activity
OP861_07295	COG1686	Belongs to the peptidase S11 family
OP861_07300	COG1760	l-serine dehydratase
OP861_07305	COG0814	amino acid
OP861_07310	COG1349	DNA-binding transcription factor activity
OP861_07320	COG0671	phosphoesterase, PA-phosphatase related
OP861_07330	COG2985	domain, Protein
OP861_07330	COG0569	domain protein
OP861_07350	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OP861_07355	COG3842	ATPase activity
OP861_07360	COG1176	ABC-type spermidine putrescine transport system, permease component I
OP861_07365	COG1177	transmembrane transport
OP861_07380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP861_07385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OP861_07390	COG1454	alcohol dehydrogenase
OP861_07395	COG1012	belongs to the aldehyde dehydrogenase family
OP861_07400	COG1414	Transcriptional regulator
OP861_07405	COG4160	amino acid transport
OP861_07410	COG4215	(ABC) transporter
OP861_07415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP861_07420	COG1126	abc transporter atp-binding protein
OP861_07430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OP861_07435	COG0702	epimerase
OP861_07440	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
OP861_07450	COG0028	Belongs to the TPP enzyme family
OP861_07455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OP861_07460	COG1151	hydroxylamine reductase activity
OP861_07465	COG2431	L-lysine efflux transmembrane transporter activity
OP861_07470	COG3593	DNA synthesis involved in DNA repair
OP861_07475	COG2990	Protein conserved in bacteria
OP861_07480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP861_07490	COG1278	Cold shock
OP861_07495	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OP861_07500	COG0542	response to heat
OP861_07505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OP861_07515	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OP861_07525	COG0492	ferredoxin-NADP+ reductase activity
OP861_07535	COG1674	ftsk spoiiie
OP861_07535	COG3107	peptidoglycan biosynthetic process
OP861_07540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OP861_07545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OP861_07550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OP861_07555	COG2814	Major facilitator Superfamily
OP861_07560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OP861_07565	COG1882	Formate acetyltransferase
OP861_07570	COG2116	formate transmembrane transporter activity
OP861_07575	COG1944	ATP diphosphatase activity
OP861_07580	COG0252	asparaginase activity
OP861_07590	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OP861_07600	COG0539	negative regulation of cytoplasmic translation
OP861_07605	COG0776	regulation of translation
OP861_07610	COG2333	competence protein COMEC
OP861_07610	COG0658	competence protein
OP861_07620	COG1663	tetraacyldisaccharide 4'-kinase activity
OP861_07625	COG5383	Protein conserved in bacteria
OP861_07635	COG1278	Cold shock
OP861_07640	COG2835	tetraacyldisaccharide 4'-kinase activity
OP861_07650	COG3173	Aminoglycoside phosphotransferase
OP861_07655	COG1434	Gram-negative-bacterium-type cell wall biogenesis
OP861_07660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OP861_07665	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
OP861_07675	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
OP861_07680	COG2989	Protein conserved in bacteria
OP861_07685	COG3108	Peptidase M15
OP861_07690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OP861_07695	COG2200	EAL domain
OP861_07700	COG1448	Aminotransferase
OP861_07710	COG0017	Asparaginyl-tRNA synthetase
OP861_07715	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OP861_07720	COG0308	aminopeptidase N
OP861_07725	COG0167	dihydroorotate dehydrogenase activity
OP861_07735	COG3217	Mosc domain protein beta barrel domain protein
OP861_07735	COG0633	Ferredoxin
OP861_07740	COG0116	Belongs to the methyltransferase superfamily
OP861_07740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OP861_07745	COG0488	(ABC) transporter
OP861_07750	COG2995	paraquat-inducible protein a
OP861_07755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OP861_07755	COG3008	intermembrane lipid transfer
OP861_07760	COG3009	Protein conserved in bacteria
OP861_07765	COG3130	regulation of translation
OP861_07770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OP861_07780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OP861_07785	COG1067	ATP-dependent peptidase activity
OP861_07790	COG3120	sequence-specific DNA binding
OP861_07800	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
OP861_07805	COG3070	regulator of competence-specific genes
OP861_07810	COG1289	transmembrane transporter activity
OP861_07815	COG3304	Inner membrane component domain
OP861_07820	COG0210	DNA helicase
OP861_07835	COG1832	CoA-binding protein
OP861_07840	COG3785	DNA binding
OP861_07850	COG1254	Belongs to the acylphosphatase family
OP861_07855	COG2920	part of a sulfur-relay system
OP861_07880	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OP861_07900	COG3121	Chaperone
OP861_07930	COG0058	SHG alpha-glucan phosphorylase activity
OP861_07940	COG0745	RESPONSE REGULATOR receiver
OP861_07945	COG1366	Belongs to the anti-sigma-factor antagonist family
OP861_07950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OP861_07960	COG1215	transferase activity, transferring glycosyl groups
OP861_07980	COG3250	beta-galactosidase activity
OP861_07995	COG0583	DNA-binding transcription factor activity
OP861_08010	COG3960	tartronate-semialdehyde synthase activity
OP861_08015	COG3622	Belongs to the hyi family
OP861_08020	COG2084	Dehydrogenase
OP861_08025	COG1953	Uracil, thiamine, allantoin
OP861_08035	COG2233	PERMEase
OP861_08040	COG1929	Belongs to the glycerate kinase type-1 family
OP861_08045	COG3257	ureidoglycine aminohydrolase activity
OP861_08050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OP861_08055	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
OP861_08060	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OP861_08065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OP861_08075	COG0549	Belongs to the carbamate kinase family
OP861_08085	COG3188	usher protein
OP861_08100	COG1388	LysM domain
OP861_08100	COG1470	cell adhesion involved in biofilm formation
OP861_08120	COG0076	glutamate decarboxylase activity
OP861_08125	COG0531	amino acid
OP861_08135	COG2771	luxR family
OP861_08140	COG3916	Acyl-homoserine-lactone synthase
OP861_08175	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
OP861_08180	COG2943	transferase activity, transferring hexosyl groups
OP861_08185	COG5645	(Lipo)protein
OP861_08205	COG2814	Major facilitator Superfamily
OP861_08210	COG2259	Doxx family
OP861_08215	COG1560	Kdo2-lipid A biosynthetic process
OP861_08255	COG0628	permease
OP861_08285	COG0418	dihydroorotase activity
OP861_08290	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OP861_08295	COG1530	ribonuclease E activity
OP861_08300	COG0564	pseudouridine synthase activity
OP861_08310	COG1399	metal-binding, possibly nucleic acid-binding protein
OP861_08315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OP861_08320	COG0416	fatty acid biosynthetic process
OP861_08330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OP861_08345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OP861_08350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OP861_08355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OP861_08360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OP861_08365	COG0470	DNA polymerase III
OP861_08370	COG0084	hydrolase, TatD family'
OP861_08375	COG1263	PTS System
OP861_08375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP861_08385	COG0537	adenosine 5'-monophosphoramidase activity
OP861_08390	COG5633	Lipoprotein
OP861_08395	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
OP861_08410	COG3150	esterase
OP861_08415	COG1252	NADH dehydrogenase
OP861_08420	COG3134	Outer membrane lipoprotein
OP861_08425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OP861_08430	COG4591	ABC-type transport system involved in lipoprotein release permease component
OP861_08440	COG4591	ABC-type transport system involved in lipoprotein release permease component
OP861_08445	COG1940	carbohydrate kinase activity
OP861_08460	COG2850	peptidyl-arginine hydroxylation
OP861_08470	COG0745	RESPONSE REGULATOR receiver
OP861_08480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OP861_08485	COG2915	High frequency lysogenization protein hflD homolog
OP861_08490	COG0482	sulfurtransferase activity
OP861_08500	COG1187	pseudouridine synthase activity
OP861_08505	COG0538	isocitrate dehydrogenase activity
OP861_08525	COG3397	chitin binding
OP861_08535	COG0840	transmembrane signaling receptor activity
OP861_08545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OP861_08555	COG2873	o-acetylhomoserine
OP861_08560	COG0702	epimerase
OP861_08565	COG1733	regulation of RNA biosynthetic process
OP861_08580	COG0697	spore germination
OP861_08590	COG3755	Protein conserved in bacteria
OP861_08600	COG2203	Gaf domain
OP861_08600	COG3706	GGDEF domain
OP861_08600	COG4251	negative regulation of phosphorylation
OP861_08600	COG5001	Diguanylate cyclase
OP861_08610	COG1132	(ABC) transporter
OP861_08630	COG2207	Transcriptional regulator
OP861_08665	COG1113	amino acid transport
OP861_08685	COG1496	oxidoreductase activity
OP861_08695	COG2226	methyltransferase
OP861_08705	COG3447	MASE1 domain protein
OP861_08705	COG5001	Diguanylate cyclase
OP861_08705	COG5002	protein histidine kinase activity
OP861_08715	COG1971	Probably functions as a manganese efflux pump
OP861_08720	COG4811	Protein of unknown function (DUF986)
OP861_08725	COG3716	PTS system mannose fructose sorbose family IID component
OP861_08730	COG3715	PTS system
OP861_08735	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP861_08735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP861_08740	COG1253	flavin adenine dinucleotide binding
OP861_08745	COG1760	l-serine dehydratase
OP861_08750	COG0494	nUDIX hydrolase
OP861_08760	COG3140	Belongs to the UPF0181 family
OP861_08765	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
OP861_08770	COG0513	Belongs to the DEAD box helicase family
OP861_08775	COG3141	response to X-ray
OP861_08780	COG3097	Belongs to the UPF0267 family
OP861_08790	COG1770	oligopeptidase
OP861_08795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OP861_08810	COG1528	Iron-storage protein
OP861_08815	COG2372	response to copper ion
OP861_08820	COG1276	copper resistance
OP861_08830	COG0582	viral genome integration into host DNA
OP861_08870	COG1396	sequence-specific DNA binding
OP861_08895	COG3756	Protein conserved in bacteria
OP861_08940	COG3081	Nucleoid-associated protein
OP861_08950	COG3772	lysozyme
OP861_08980	COG1475	DNA binding
OP861_09235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OP861_09240	COG2423	ornithine cyclodeaminase activity
OP861_09295	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OP861_09325	COG0668	transmembrane transport
OP861_09330	COG1187	pseudouridine synthase activity
OP861_09340	COG0697	spore germination
OP861_09360	COG0625	glutathione transferase activity
OP861_09400	COG3706	GGDEF domain
OP861_09400	COG2203	Gaf domain
OP861_09400	COG4251	negative regulation of phosphorylation
OP861_09400	COG5001	Diguanylate cyclase
OP861_09405	COG2814	Major facilitator Superfamily
OP861_09415	COG3008	intermembrane lipid transfer
OP861_09420	COG2995	paraquat-inducible protein a
OP861_09425	COG1956	GAF domain-containing protein
OP861_09435	COG0793	Belongs to the peptidase S41A family
OP861_09440	COG0501	Belongs to the peptidase M48B family
OP861_09445	COG2814	Major facilitator Superfamily
OP861_09450	COG0823	Involved in the tonB-independent uptake of proteins
OP861_09460	COG3023	N-Acetylmuramoyl-L-alanine amidase
OP861_09465	COG1823	symporter activity
OP861_09470	COG1988	membrane-bound metal-dependent
OP861_09475	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OP861_09485	COG3842	ATPase activity
OP861_09490	COG0395	ABC-type sugar transport system, permease component
OP861_09495	COG1175	transmembrane transport
OP861_09505	COG1028	Short-chain dehydrogenase reductase Sdr
OP861_09520	COG1917	Cupin 2, conserved barrel domain protein
OP861_09525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OP861_09535	COG0583	DNA-binding transcription factor activity
OP861_09540	COG0427	acetyl-CoA hydrolase
OP861_09545	COG1024	Enoyl-CoA hydratase
OP861_09550	COG1703	isobutyryl-CoA mutase activity
OP861_09555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OP861_09555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OP861_09560	COG3001	Fructosamine kinase
OP861_09565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OP861_09570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OP861_09575	COG1121	(ABC) transporter
OP861_09580	COG0803	Belongs to the bacterial solute-binding protein 9 family
OP861_09610	COG3623	hexulose-6-phosphate isomerase
OP861_09615	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
OP861_09620	COG1070	Carbohydrate kinase
OP861_09640	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_09645	COG1129	ABC transporter
OP861_09650	COG1414	Transcriptional regulator
OP861_09655	COG1811	Na channel or pump
OP861_09660	COG4249	Peptidase C14 caspase catalytic subunit p20
OP861_09670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OP861_09675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OP861_09695	COG0776	regulation of translation
OP861_09705	COG4139	cobalamin transport
OP861_09710	COG0386	Belongs to the glutathione peroxidase family
OP861_09715	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
OP861_09720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OP861_09725	COG0463	Glycosyl transferase, family 2
OP861_09735	COG0726	polysaccharide deacetylase
OP861_09740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OP861_09750	COG2076	Multidrug Resistance protein
OP861_09755	COG0791	NLP P60 protein
OP861_09760	COG0095	Lipoate-protein ligase
OP861_09770	COG4558	Periplasmic binding protein
OP861_09775	COG3720	iron ion transport
OP861_09790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OP861_09795	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OP861_09800	COG0574	Belongs to the PEP-utilizing enzyme family
OP861_09800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OP861_09810	COG0628	permease
OP861_09815	COG0247	lactate metabolic process
OP861_09815	COG0277	FAD linked oxidase domain protein
OP861_09820	COG2050	protein possibly involved in aromatic compounds catabolism
OP861_09825	COG0316	Belongs to the HesB IscA family
OP861_09830	COG0719	Fe-S assembly protein
OP861_09835	COG0396	ATPase activity
OP861_09840	COG0719	Fe-S assembly protein
OP861_09850	COG2166	iron-sulfur cluster assembly
OP861_09855	COG1388	LysM domain
OP861_09855	COG1376	ErfK ybiS ycfS ynhG family protein
OP861_09890	COG0534	Mate efflux family protein
OP861_09895	COG0307	riboflavin synthase, alpha
OP861_09900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OP861_09905	COG2814	Major facilitator Superfamily
OP861_09910	COG0583	DNA-binding transcription factor activity
OP861_09915	COG1609	Transcriptional regulator
OP861_09930	COG0791	NLP P60 protein
OP861_09935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OP861_09940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OP861_09945	COG0346	lactoylglutathione lyase activity
OP861_09950	COG1902	pentaerythritol trinitrate reductase activity
OP861_09955	COG1309	transcriptional regulator
OP861_09960	COG2194	sulfuric ester hydrolase activity
OP861_09965	COG3313	Fe-S protein
OP861_09970	COG4989	oxidoreductase activity
OP861_09975	COG1289	transmembrane transporter activity
OP861_09980	COG1566	PFAM secretion protein HlyD family protein
OP861_09990	COG1846	Transcriptional regulator
OP861_09995	COG3133	Outer membrane lipoprotein
OP861_10000	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OP861_10005	COG3895	Periplasmic Protein
OP861_10015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OP861_10025	COG0625	glutathione transferase activity
OP861_10045	COG3104	oligopeptide transport
OP861_10050	COG0583	DNA-binding transcription factor activity
OP861_10055	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OP861_10055	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OP861_10060	COG4172	Belongs to the ABC transporter superfamily
OP861_10070	COG4171	peptide transport system, permease
OP861_10075	COG4168	peptide transport system, permease
OP861_10080	COG4166	transmembrane transport
OP861_10095	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OP861_10100	COG1842	Phage shock protein A
OP861_10110	COG1983	PspC domain protein
OP861_10120	COG3106	COG3106 Predicted ATPase
OP861_10125	COG3768	UPF0283 membrane protein
OP861_10130	COG5654	RES domain protein
OP861_10135	COG5642	Protein of unknown function (DUF2384)
OP861_10145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
OP861_10150	COG4948	Mandelate Racemase Muconate Lactonizing
OP861_10155	COG2866	Carboxypeptidase
OP861_10160	COG4166	transmembrane transport
OP861_10165	COG0598	Magnesium transport protein CorA
OP861_10170	COG0037	tRNA processing
OP861_10175	COG0674	pyruvate-flavodoxin oxidoreductase activity
OP861_10175	COG1013	pyruvate-flavodoxin oxidoreductase activity
OP861_10175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
OP861_10175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP861_10185	COG1285	pathogenesis
OP861_10190	COG3042	response to heat
OP861_10195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OP861_10200	COG2911	Protein conserved in bacteria
OP861_10210	COG3784	Protein of unknown function (DUF1318)
OP861_10220	COG1070	Carbohydrate kinase
OP861_10225	COG0246	Mannitol dehydrogenase
OP861_10235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OP861_10240	COG1643	Atp-dependent helicase
OP861_10255	COG3591	Belongs to the peptidase S1B family
OP861_10265	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
OP861_10270	COG2205	protein histidine kinase activity
OP861_10275	COG0745	RESPONSE REGULATOR receiver
OP861_10285	COG0531	amino acid
OP861_10295	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
OP861_10300	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
OP861_10305	COG0589	response to stress
OP861_10310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OP861_10315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OP861_10330	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
OP861_10340	COG1028	Short-chain dehydrogenase reductase Sdr
OP861_10350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OP861_10355	COG0738	Major facilitator superfamily
OP861_10370	COG0583	DNA-binding transcription factor activity
OP861_10380	COG1011	Hydrolase
OP861_10385	COG0251	oxidation-reduction process
OP861_10390	COG0440	acetolactate synthase activity
OP861_10395	COG0028	Belongs to the TPP enzyme family
OP861_10425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OP861_10435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OP861_10445	COG1477	protein flavinylation
OP861_10460	COG4215	(ABC) transporter
OP861_10470	COG1522	sequence-specific DNA binding
OP861_10480	COG0446	pyridine nucleotide-disulphide oxidoreductase
OP861_10485	COG1773	rubredoxin
OP861_10485	COG0426	domain, Protein
OP861_10490	COG3604	Transcriptional regulator
OP861_10495	COG0625	glutathione transferase activity
OP861_10520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
OP861_10525	COG1393	Belongs to the ArsC family
OP861_10545	COG1649	PFAM Uncharacterised BCR, COG1649
OP861_10550	COG0110	maltose O-acetyltransferase activity
OP861_10555	COG4221	oxidoreductase activity
OP861_10560	COG1742	UPF0060 membrane protein
OP861_10580	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OP861_10585	COG1940	carbohydrate kinase activity
OP861_10590	COG0583	DNA-binding transcription factor activity
OP861_10595	COG2814	Major facilitator Superfamily
OP861_10620	COG0114	fumarate hydratase activity
OP861_10630	COG5339	Protein conserved in bacteria
OP861_10640	COG1609	Transcriptional regulator
OP861_10645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP861_10645	COG1263	PTS System
OP861_10650	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OP861_10655	COG2188	Transcriptional regulator
OP861_10660	COG4948	Mandelate Racemase Muconate Lactonizing
OP861_10665	COG2190	(PTS) system
OP861_10665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP861_10665	COG1263	PTS System
OP861_10670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OP861_10675	COG0385	Bile acid
OP861_10680	COG0673	inositol 2-dehydrogenase activity
OP861_10690	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_10695	COG1129	ABC transporter
OP861_10700	COG1879	ABC-type sugar transport system periplasmic component
OP861_10715	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OP861_10720	COG2723	6-phospho-beta-galactosidase activity
OP861_10725	COG2274	protein secretion by the type I secretion system
OP861_10735	COG2274	protein secretion by the type I secretion system
OP861_10740	COG2759	Belongs to the formate--tetrahydrofolate ligase family
OP861_10750	COG4657	Part of a membrane complex involved in electron transport
OP861_10760	COG4656	Part of a membrane complex involved in electron transport
OP861_10765	COG2207	Transcriptional regulator
OP861_10765	COG3708	Transcriptional regulator
OP861_10770	COG4658	electron transport chain
OP861_10775	COG4659	FMN binding
OP861_10785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OP861_10790	COG0243	molybdopterin cofactor binding
OP861_10795	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
OP861_10800	COG1966	Carbon starvation protein
OP861_10805	COG2879	small protein
OP861_10810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OP861_10815	COG1349	DNA-binding transcription factor activity
OP861_10835	COG0023	Translation Initiation Factor
OP861_10855	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
OP861_10860	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
OP861_10865	COG0671	phosphoesterase, PA-phosphatase related
OP861_10875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OP861_10885	COG0583	DNA-binding transcription factor activity
OP861_10900	COG0616	signal peptide processing
OP861_10905	COG1028	Short-chain dehydrogenase reductase Sdr
OP861_10920	COG1187	pseudouridine synthase activity
OP861_10930	COG0009	L-threonylcarbamoyladenylate synthase
OP861_10935	COG0613	PHP domain protein
OP861_10950	COG0512	Glutamine amidotransferase of anthranilate synthase
OP861_10960	COG0135	phosphoribosylanthranilate isomerase activity
OP861_10960	COG0134	indole-3-glycerol-phosphate synthase activity
OP861_10965	COG0133	tryptophan synthase activity
OP861_10970	COG0159	tryptophan synthase activity
OP861_10980	COG3047	cAMP biosynthetic process
OP861_10985	COG0727	PFAM Uncharacterised protein family (UPF0153)
OP861_11000	COG2917	probably involved in intracellular septation
OP861_11010	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
OP861_11015	COG2350	Protein conserved in bacteria
OP861_11040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OP861_11045	COG3099	Belongs to the UPF0263 family
OP861_11055	COG0444	Belongs to the ABC transporter superfamily
OP861_11060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OP861_11080	COG2095	MarC family integral membrane protein
OP861_11085	COG1012	belongs to the aldehyde dehydrogenase family
OP861_11085	COG1454	alcohol dehydrogenase
OP861_11095	COG2916	Histone family protein nucleoid-structuring protein H-NS
OP861_11105	COG0745	RESPONSE REGULATOR receiver
OP861_11110	COG1752	Esterase of the alpha-beta hydrolase superfamily
OP861_11120	COG3012	SEC-C Motif Domain Protein
OP861_11125	COG0788	formyltetrahydrofolate deformylase activity
OP861_11145	COG0583	DNA-binding transcription factor activity
OP861_11150	COG0708	Exodeoxyribonuclease III
OP861_11155	COG0494	nUDIX hydrolase
OP861_11165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OP861_11175	COG0778	Nitroreductase
OP861_11180	COG0616	signal peptide processing
OP861_11185	COG0252	asparaginase activity
OP861_11190	COG1335	isochorismatase
OP861_11195	COG3139	Protein of unknown function (DUF1315)
OP861_11215	COG3713	MltA-interacting MipA family protein
OP861_11220	COG2766	serine protein kinase
OP861_11225	COG2718	Belongs to the UPF0229 family
OP861_11235	COG2199	diguanylate cyclase activity
OP861_11235	COG2202	Pas domain
OP861_11235	COG2200	EAL domain
OP861_11240	COG2814	Major facilitator Superfamily
OP861_11245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OP861_11250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OP861_11255	COG2719	SpoVR family
OP861_11260	COG2186	Transcriptional regulator
OP861_11265	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OP861_11270	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
OP861_11290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OP861_11300	COG2983	Belongs to the UPF0260 family
OP861_11305	COG0179	Fumarylacetoacetate (FAA) hydrolase
OP861_11310	COG2951	lytic endotransglycosylase activity
OP861_11315	COG3100	YcgL domain-containing protein
OP861_11325	COG0850	regulation of cytokinetic process
OP861_11330	COG2894	cell division
OP861_11335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
OP861_11340	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
OP861_11345	COG0318	PFAM AMP-dependent synthetase and ligase
OP861_11350	COG3065	identical protein binding
OP861_11360	COG1199	ATP-dependent helicase activity
OP861_11365	COG0251	oxidation-reduction process
OP861_11370	COG2076	Multidrug Resistance protein
OP861_11375	COG2076	Multidrug Resistance protein
OP861_11380	COG0800	Aldolase
OP861_11385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OP861_11390	COG1737	Transcriptional regulator
OP861_11395	COG0469	pyruvate kinase activity
OP861_11400	COG1560	Kdo2-lipid A biosynthetic process
OP861_11405	COG0739	heme binding
OP861_11410	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
OP861_11415	COG1121	(ABC) transporter
OP861_11420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OP861_11425	COG3104	oligopeptide transport
OP861_11430	COG2255	four-way junction helicase activity
OP861_11435	COG0632	four-way junction helicase activity
OP861_11450	COG0494	nUDIX hydrolase
OP861_11455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OP861_11460	COG1335	isochorismatase
OP861_11465	COG1801	Protein of unknown function DUF72
OP861_11470	COG3788	relative of glutathione S-transferase, MAPEG superfamily
OP861_11480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OP861_11485	COG3142	Participates in the control of copper homeostasis
OP861_11490	COG3102	Protein conserved in bacteria
OP861_11505	COG0673	inositol 2-dehydrogenase activity
OP861_11515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OP861_11520	COG0477	Major facilitator Superfamily
OP861_11530	COG3381	protein complex oligomerization
OP861_11540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OP861_11560	COG3706	GGDEF domain
OP861_11565	COG0659	secondary active sulfate transmembrane transporter activity
OP861_11585	COG2890	protein-(glutamine-N5) methyltransferase activity
OP861_11590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OP861_11595	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OP861_11600	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OP861_11610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OP861_11620	COG0193	aminoacyl-tRNA hydrolase activity
OP861_11630	COG0012	GTP binding
OP861_11635	COG0582	viral genome integration into host DNA
OP861_11660	COG2205	protein histidine kinase activity
OP861_11680	COG4942	peptidase
OP861_11690	COG3443	Belongs to the bacterial solute-binding protein 9 family
OP861_11695	COG1309	transcriptional regulator
OP861_11705	COG2814	Major facilitator Superfamily
OP861_11720	COG4211	Belongs to the binding-protein-dependent transport system permease family
OP861_11725	COG1129	ABC transporter
OP861_11750	COG1228	amidohydrolase
OP861_11765	COG2988	succinylglutamate desuccinylase activity
OP861_11770	COG3724	N-succinylarginine dihydrolase activity
OP861_11780	COG3138	arginine N-succinyltransferase
OP861_11785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OP861_11790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OP861_11795	COG1271	oxidase subunit
OP861_11800	COG1294	oxidase, subunit
OP861_11810	COG3850	Histidine kinase
OP861_11815	COG0583	DNA-binding transcription factor activity
OP861_11820	COG2814	Major facilitator Superfamily
OP861_11830	COG0387	Pfam Sodium calcium exchanger
OP861_11835	COG1702	phosphate starvation-inducible protein PhoH
OP861_11845	COG3658	cytochrome
OP861_11850	COG1215	transferase activity, transferring glycosyl groups
OP861_11855	COG0726	polysaccharide deacetylase
OP861_11855	COG1649	PFAM Uncharacterised BCR, COG1649
OP861_11860	COG0457	Tetratricopeptide repeat
OP861_11865	COG0006	proline dipeptidase activity
OP861_11870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OP861_11895	COG0577	efflux transmembrane transporter activity
OP861_11895	COG1136	(ABC) transporter
OP861_11905	COG0577	efflux transmembrane transporter activity
OP861_11905	COG1136	(ABC) transporter
OP861_11920	COG0672	)-iron permease
OP861_11930	COG1447	Phosphotransferase system cellobiose-specific component IIA
OP861_11935	COG2723	6-phospho-beta-galactosidase activity
OP861_11940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OP861_11945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OP861_11950	COG1609	Transcriptional regulator
OP861_11965	COG2066	Belongs to the glutaminase family
OP861_11970	COG2610	gluconate transmembrane transporter activity
OP861_11975	COG3622	Belongs to the hyi family
OP861_11980	COG0235	Class ii aldolase
OP861_11985	COG3395	kinase activity
OP861_11990	COG2084	Dehydrogenase
OP861_11995	COG1349	DNA-binding transcription factor activity
OP861_12000	COG3290	protein histidine kinase activity
OP861_12005	COG4565	transcriptional regulatory protein
OP861_12010	COG3493	citrate carrier protein
OP861_12020	COG2181	nitrate reductase activity
OP861_12025	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
OP861_12030	COG1140	nitrate reductase beta subunit
OP861_12035	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
OP861_12040	COG2223	nitrite transmembrane transporter activity
OP861_12045	COG2197	response regulator
OP861_12050	COG3189	MarR family transcriptional regulator
OP861_12060	COG2223	nitrite transmembrane transporter activity
OP861_12065	COG0561	phosphatase activity
OP861_12070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OP861_12085	COG2197	response regulator
OP861_12100	COG3188	usher protein
OP861_12105	COG3121	Chaperone
OP861_12140	COG0583	DNA-binding transcription factor activity
OP861_12155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
OP861_12185	COG4974	Belongs to the 'phage' integrase family
OP861_12245	COG4695	Portal protein
OP861_12310	COG2755	lipolytic protein G-D-S-L family
OP861_12310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
OP861_12385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OP861_12475	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
OP861_12555	COG3772	lysozyme
OP861_12610	COG0305	Participates in initiation and elongation during chromosome replication
OP861_12695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OP861_12700	COG0322	excinuclease ABC activity
OP861_12705	COG2197	response regulator
OP861_12715	COG3136	membrane protein required for alginate biosynthesis
OP861_12725	COG0840	transmembrane signaling receptor activity
OP861_12730	COG0366	Alpha amylase catalytic
OP861_12755	COG2199	diguanylate cyclase activity
OP861_12755	COG2203	Gaf domain
OP861_12765	COG1113	amino acid transport
OP861_12775	COG1881	PFAM PEBP family protein
OP861_12795	COG2822	iron ion transport
OP861_12800	COG0672	)-iron permease
OP861_12805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OP861_12810	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OP861_12810	COG0506	proline dehydrogenase activity
OP861_12810	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OP861_12825	COG1126	abc transporter atp-binding protein
OP861_12830	COG0765	amino acid transport
OP861_12835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP861_12840	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OP861_12850	COG1191	sigma factor activity
OP861_12880	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
OP861_12885	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OP861_12910	COG1677	Flagellar hook-basal body complex protein FliE
OP861_12925	COG1317	bacterial-type flagellum organization
OP861_12980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OP861_12985	COG1256	bacterial-type flagellum assembly
OP861_13020	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
OP861_13025	COG1558	bacterial-type flagellum-dependent cell motility
OP861_13030	COG1815	bacterial-type flagellum-dependent cell motility
OP861_13040	COG2747	anti-sigma28 factor FlgM
OP861_13045	COG3418	PFAM FlgN family protein
OP861_13060	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OP861_13065	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OP861_13070	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
OP861_13075	COG0745	RESPONSE REGULATOR receiver
OP861_13085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OP861_13090	COG0840	transmembrane signaling receptor activity
OP861_13095	COG0840	transmembrane signaling receptor activity
OP861_13100	COG0835	chemotaxis
OP861_13105	COG0643	Histidine kinase
OP861_13105	COG2198	Histidine kinase
OP861_13130	COG0589	response to stress
OP861_13135	COG2130	NADP-dependent
OP861_13145	COG1285	pathogenesis
OP861_13150	COG0840	transmembrane signaling receptor activity
OP861_13165	COG1609	Transcriptional regulator
OP861_13170	COG3250	beta-galactosidase activity
OP861_13175	COG0604	alcohol dehydrogenase
OP861_13175	COG1028	Short-chain dehydrogenase reductase Sdr
OP861_13175	COG3321	synthase
OP861_13205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OP861_13210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OP861_13220	COG2211	Major facilitator Superfamily
OP861_13225	COG1501	Belongs to the glycosyl hydrolase 31 family
OP861_13245	COG2084	Dehydrogenase
OP861_13250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OP861_13255	COG1349	DNA-binding transcription factor activity
OP861_13275	COG3121	Chaperone
OP861_13295	COG3228	Belongs to the MtfA family
OP861_13350	COG2211	Major facilitator Superfamily
OP861_13360	COG2814	Major facilitator Superfamily
OP861_13370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OP861_13385	COG0471	metal ion transport
OP861_13400	COG3051	citrate lyase alpha subunit
OP861_13405	COG2301	Belongs to the HpcH HpaI aldolase family
OP861_13410	COG3052	prosthetic group binding
OP861_13415	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
OP861_13420	COG3290	protein histidine kinase activity
OP861_13425	COG4565	transcriptional regulatory protein
OP861_13440	COG2271	Major facilitator Superfamily
OP861_13445	COG1840	ABC-type Fe3 transport system, periplasmic component
OP861_13455	COG3842	ATPase activity
OP861_13470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP861_13470	COG2205	protein histidine kinase activity
OP861_13495	COG3121	Chaperone
OP861_13645	COG3755	Protein conserved in bacteria
OP861_13665	COG3179	chitinase
OP861_13710	COG0583	DNA-binding transcription factor activity
OP861_13720	COG1349	DNA-binding transcription factor activity
OP861_13725	COG0561	phosphatase activity
OP861_13740	COG0784	Response regulator, receiver
OP861_13740	COG0835	chemotaxis
OP861_13745	COG0534	Mate efflux family protein
OP861_13750	COG0137	argininosuccinate synthase activity
OP861_13755	COG2211	Major facilitator Superfamily
OP861_13760	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
OP861_13770	COG0583	DNA-binding transcription factor activity
OP861_13775	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OP861_13795	COG1492	cobalamin metabolic process
OP861_13860	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
OP861_13870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
OP861_13930	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
OP861_13945	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
OP861_13950	COG2096	Adenosyltransferase
OP861_13965	COG4656	Part of a membrane complex involved in electron transport
OP861_13985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OP861_13995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OP861_14010	COG1129	ABC transporter
OP861_14015	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_14040	COG2925	Exonuclease
OP861_14045	COG0531	amino acid
OP861_14050	COG0371	Dehydrogenase
OP861_14055	COG1129	ABC transporter
OP861_14060	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_14065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OP861_14075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OP861_14085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OP861_14090	COG0131	Imidazoleglycerol-phosphate dehydratase
OP861_14090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OP861_14105	COG0107	imidazoleglycerol-phosphate synthase activity
OP861_14110	COG0140	phosphoribosyl-ATP diphosphatase activity
OP861_14110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OP861_14115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OP861_14125	COG0546	phosphoglycolate phosphatase activity
OP861_14170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OP861_14175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OP861_14180	COG1253	flavin adenine dinucleotide binding
OP861_14185	COG3069	C4-dicarboxylate transmembrane transporter activity
OP861_14190	COG2982	Protein involved in outer membrane biogenesis
OP861_14200	COG0572	uridine kinase
OP861_14205	COG0489	protein tyrosine kinase activity
OP861_14210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OP861_14210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OP861_14230	COG2814	Major facilitator Superfamily
OP861_14235	COG1380	Effector of murein hydrolase LrgA
OP861_14240	COG1346	cytolysis
OP861_14260	COG0281	malic enzyme
OP861_14265	COG2949	membrane
OP861_14270	COG0298	carbon dioxide binding
OP861_14275	COG0375	protein maturation
OP861_14280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP861_14285	COG0651	ATP synthesis coupled electron transport
OP861_14290	COG0650	Formate hydrogenlyase subunit 4
OP861_14295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OP861_14300	COG4237	Hydrogenase 4 membrane
OP861_14305	COG0651	ATP synthesis coupled electron transport
OP861_14310	COG3261	NADH dehydrogenase
OP861_14310	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
OP861_14315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OP861_14320	COG3260	NADH ubiquinone oxidoreductase 20
OP861_14330	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
OP861_14335	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP861_14340	COG3383	formate dehydrogenase (NAD+) activity
OP861_14345	COG3604	Transcriptional regulator
OP861_14350	COG2116	formate transmembrane transporter activity
OP861_14370	COG1609	Transcriptional regulator
OP861_14375	COG2311	Membrane
OP861_14380	COG0302	gtp cyclohydrolase
OP861_14385	COG0477	Major facilitator Superfamily
OP861_14390	COG0583	DNA-binding transcription factor activity
OP861_14420	COG1136	(ABC) transporter
OP861_14430	COG0477	Major facilitator Superfamily
OP861_14440	COG0303	'Molybdopterin
OP861_14445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OP861_14450	COG0488	(ABC) transporter
OP861_14470	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
OP861_14485	COG4106	trans-aconitate 2-methyltransferase activity
OP861_14495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OP861_14500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP861_14505	COG0765	amino acid transport
OP861_14510	COG1126	abc transporter atp-binding protein
OP861_14530	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
OP861_14535	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OP861_14540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OP861_14560	COG0697	spore germination
OP861_14570	COG0583	DNA-binding transcription factor activity
OP861_14575	COG1028	Short-chain dehydrogenase reductase Sdr
OP861_14585	COG1174	glycine betaine transport
OP861_14590	COG1125	glycine betaine transport
OP861_14595	COG1174	glycine betaine transport
OP861_14600	COG1732	Glycine betaine
OP861_14610	COG0673	inositol 2-dehydrogenase activity
OP861_14615	COG2897	thiosulfate sulfurtransferase activity
OP861_14645	COG4807	Protein conserved in bacteria
OP861_14650	COG3639	organic phosphonate transmembrane transporter activity
OP861_14660	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
OP861_14670	COG2261	transglycosylase associated protein
OP861_14690	COG0277	FAD linked oxidase domain protein
OP861_14695	COG1686	Belongs to the peptidase S11 family
OP861_14705	COG2239	Acts as a magnesium transporter
OP861_14710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OP861_14715	COG0513	Belongs to the DEAD box helicase family
OP861_14720	COG1309	transcriptional regulator
OP861_14725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP861_14730	COG1131	(ABC) transporter
OP861_14735	COG0842	Transport permease protein
OP861_14740	COG0842	Transport permease protein
OP861_14745	COG0670	Belongs to the BI1 family
OP861_14750	COG0314	molybdopterin synthase activity
OP861_14755	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OP861_14760	COG0315	cyclic pyranopterin monophosphate synthase activity
OP861_14765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OP861_14770	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OP861_14775	COG1120	ATPase activity
OP861_14780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OP861_14795	COG4628	conserved protein (DUF2132)
OP861_14800	COG0556	nucleotide-excision repair
OP861_14815	COG2226	methyltransferase
OP861_14825	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OP861_14835	COG2706	6-phosphogluconolactonase activity
OP861_14840	COG0561	phosphatase activity
OP861_14850	COG4149	molybdate abc transporter
OP861_14855	COG0725	ABC transporter, periplasmic molybdate-binding protein
OP861_14865	COG2005	Transcriptional regulator
OP861_14865	COG3585	molybdate ion transport
OP861_14870	COG1119	ATPase activity
OP861_14880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OP861_14890	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
OP861_14895	COG2017	converts alpha-aldose to the beta-anomer
OP861_14905	COG0588	phosphoglycerate mutase activity
OP861_14910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OP861_14915	COG2197	response regulator
OP861_14920	COG2205	protein histidine kinase activity
OP861_14920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP861_14925	COG1230	cation diffusion facilitator family transporter
OP861_14935	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OP861_14975	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
OP861_14980	COG2885	chlorophyll binding
OP861_14985	COG0823	Involved in the tonB-independent uptake of proteins
OP861_14990	COG3064	Membrane
OP861_14990	COG3064	Membrane
OP861_14995	COG0848	biopolymer transport protein
OP861_15000	COG0811	peptide transport
OP861_15005	COG0824	Thioesterase
OP861_15010	COG3790	cyd operon protein YbgE
OP861_15015	COG4890	Cyd operon protein YbgT
OP861_15020	COG1294	oxidase, subunit
OP861_15025	COG1271	oxidase subunit
OP861_15030	COG0737	Belongs to the 5'-nucleotidase family
OP861_15035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OP861_15040	COG0045	succinate-CoA ligase (ADP-forming) activity
OP861_15045	COG0508	dehydrogenase complex catalyzes the overall conversion of
OP861_15050	COG0567	Dehydrogenase, E1 component
OP861_15060	COG1053	succinate dehydrogenase
OP861_15065	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OP861_15070	COG2009	succinate dehydrogenase
OP861_15095	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OP861_15100	COG1984	allophanate hydrolase subunit 2
OP861_15105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OP861_15110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OP861_15115	COG5212	phosphodiesterase
OP861_15125	COG3272	Protein of unknown function (DUF1722)
OP861_15145	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OP861_15150	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
OP861_15155	COG2205	protein histidine kinase activity
OP861_15160	COG0745	RESPONSE REGULATOR receiver
OP861_15170	COG0033	Phosphoglucomutase
OP861_15175	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
OP861_15205	COG0596	Alpha beta hydrolase
OP861_15215	COG0840	transmembrane signaling receptor activity
OP861_15225	COG0735	belongs to the Fur family
OP861_15245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OP861_15250	COG2190	(PTS) system
OP861_15250	COG1263	PTS System
OP861_15250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP861_15260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OP861_15265	COG1846	Transcriptional regulator
OP861_15265	COG1940	carbohydrate kinase activity
OP861_15270	COG0647	UMP catabolic process
OP861_15275	COG0367	asparagine synthase
OP861_15310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OP861_15315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OP861_15320	COG1702	phosphate starvation-inducible protein PhoH
OP861_15325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OP861_15335	COG0815	Transfers the fatty acyl group on membrane lipoproteins
OP861_15350	COG0765	amino acid transport
OP861_15355	COG0765	amino acid transport
OP861_15360	COG1126	abc transporter atp-binding protein
OP861_15370	COG2888	peptidyl-tyrosine sulfation
OP861_15375	COG0495	leucyl-tRNA aminoacylation
OP861_15380	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
OP861_15385	COG1466	dna polymerase III delta subunit
OP861_15390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OP861_15395	COG0799	negative regulation of ribosome biogenesis
OP861_15405	COG0768	penicillin binding
OP861_15410	COG0772	Belongs to the SEDS family
OP861_15415	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OP861_15420	COG1686	Belongs to the peptidase S11 family
OP861_15425	COG2921	Belongs to the UPF0250 family
OP861_15430	COG0321	lipoyl(octanoyl) transferase activity
OP861_15435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OP861_15440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OP861_15445	COG3706	GGDEF domain
OP861_15465	COG1278	Cold shock
OP861_15470	COG2197	response regulator
OP861_15480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OP861_15500	COG5265	(ABC) transporter
OP861_15510	COG2850	peptidyl-arginine hydroxylation
OP861_15515	COG0698	ribose 5-phosphate isomerase
OP861_15520	COG1737	Transcriptional regulator
OP861_15525	COG1879	ABC-type sugar transport system periplasmic component
OP861_15530	COG1129	ABC transporter
OP861_15535	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_15540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OP861_15545	COG1940	carbohydrate kinase activity
OP861_15560	COG2610	gluconate transmembrane transporter activity
OP861_15580	COG1028	Short-chain dehydrogenase reductase Sdr
OP861_15590	COG1902	pentaerythritol trinitrate reductase activity
OP861_15615	COG0583	DNA-binding transcription factor activity
OP861_15630	COG2999	glutathione oxidoreductase activity
OP861_15685	COG3122	Protein conserved in bacteria
OP861_15760	COG3240	lipase activity
OP861_15770	COG2169	Transcriptional regulator
OP861_15775	COG1486	melibiose metabolic process
OP861_15780	COG2211	Major facilitator Superfamily
OP861_15790	COG1328	CTP reductase activity
OP861_15795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OP861_15860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OP861_15865	COG2501	S4 domain
OP861_15870	COG0215	cysteine-tRNA ligase activity
OP861_15875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OP861_15880	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OP861_15885	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OP861_15890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OP861_15895	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
OP861_15900	COG4181	ATPase activity
OP861_15905	COG2755	lipolytic protein G-D-S-L family
OP861_15910	COG0300	oxidoreductase activity
OP861_15915	COG3118	belongs to the thioredoxin family
OP861_15920	COG0330	HflC and HflK could
OP861_15925	COG1585	Membrane protein implicated in regulation of membrane protease activity
OP861_15930	COG0789	Transcriptional regulator
OP861_15935	COG2217	Heavy metal translocating P-type atpase
OP861_15940	COG3735	TraB family
OP861_15945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OP861_15965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OP861_15980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
OP861_16070	COG0616	signal peptide processing
OP861_16090	COG1802	Transcriptional regulator
OP861_16090	COG4626	Terminase
OP861_16115	COG3646	Phage regulatory protein
OP861_16125	COG3179	chitinase
OP861_16150	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
OP861_16200	COG1403	HNH endonuclease
OP861_16205	COG3645	SOS response
OP861_16205	COG3646	Phage regulatory protein
OP861_16225	COG4626	Terminase
OP861_16225	COG1802	Transcriptional regulator
OP861_16260	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
OP861_16275	COG0582	viral genome integration into host DNA
OP861_16280	COG0737	Belongs to the 5'-nucleotidase family
OP861_16285	COG2223	nitrite transmembrane transporter activity
OP861_16290	COG4651	solute:proton antiporter activity
OP861_16290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OP861_16295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OP861_16315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OP861_16320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OP861_16330	COG0438	transferase activity, transferring glycosyl groups
OP861_16360	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
OP861_16365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OP861_16370	COG0563	adenylate kinase activity
OP861_16375	COG0326	Molecular chaperone. Has ATPase activity
OP861_16380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OP861_16385	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OP861_16390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OP861_16395	COG0346	lactoylglutathione lyase activity
OP861_16405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OP861_16410	COG2832	Protein of unknown function (DUF454)
OP861_16425	COG1196	nuclear chromosome segregation
OP861_16425	COG3264	Mechanosensitive ion channel
OP861_16430	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OP861_16435	COG1309	transcriptional regulator
OP861_16440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP861_16445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OP861_16450	COG0254	rRNA binding
OP861_16455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OP861_16460	COG0803	Belongs to the bacterial solute-binding protein 9 family
OP861_16465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OP861_16470	COG1121	(ABC) transporter
OP861_16495	COG3695	enzyme binding
OP861_16500	COG3126	Type III secretion system lipoprotein chaperone (YscW)
OP861_16505	COG1946	Acyl-CoA thioesterase
OP861_16510	COG0004	ammonium transporteR
OP861_16515	COG0347	Belongs to the P(II) protein family
OP861_16520	COG1132	(ABC) transporter
OP861_16525	COG1132	(ABC) transporter
OP861_16530	COG1522	sequence-specific DNA binding
OP861_16540	COG0561	phosphatase activity
OP861_16550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OP861_16555	COG0824	Thioesterase
OP861_16560	COG1555	photosystem II stabilization
OP861_16565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OP861_16570	COG0776	regulation of translation
OP861_16575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OP861_16580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OP861_16585	COG0740	serine-type endopeptidase activity
OP861_16595	COG0271	Belongs to the BolA IbaG family
OP861_16600	COG3056	Lipoprotein
OP861_16605	COG2223	nitrite transmembrane transporter activity
OP861_16615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OP861_16620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OP861_16625	COG1845	cytochrome c oxidase, subunit III
OP861_16630	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OP861_16635	COG0109	protoheme IX farnesyltransferase activity
OP861_16640	COG2814	Major facilitator Superfamily
OP861_16645	COG1666	GTP binding
OP861_16650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OP861_16655	COG0693	protein deglycase activity
OP861_16660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OP861_16660	COG0301	tRNA thio-modification
OP861_16670	COG0142	geranyltranstransferase activity
OP861_16675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OP861_16680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OP861_16685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OP861_16695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OP861_16700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OP861_16700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OP861_16705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OP861_16715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OP861_16720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OP861_16725	COG1862	Preprotein translocase
OP861_16740	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
OP861_16745	COG0450	alkyl hydroperoxide reductase
OP861_16765	COG0366	Alpha amylase catalytic
OP861_16785	COG5002	protein histidine kinase activity
OP861_16790	COG0745	RESPONSE REGULATOR receiver
OP861_16795	COG0420	3'-5' exonuclease activity
OP861_16800	COG0419	ATPase involved in DNA repair
OP861_16805	COG1940	carbohydrate kinase activity
OP861_16810	COG2974	May be involved in recombination
OP861_16815	COG3123	guanosine phosphorylase activity
OP861_16820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OP861_16835	COG2226	methyltransferase
OP861_16850	COG3459	Glycosyltransferase 36 associated
OP861_16860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OP861_16865	COG2313	pseudouridylate synthase activity
OP861_16870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OP861_16875	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OP861_16880	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OP861_16890	COG1073	alpha beta
OP861_16900	COG2195	Cleaves the N-terminal amino acid of tripeptides
OP861_16905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OP861_16910	COG1181	Belongs to the D-alanine--D-alanine ligase family
OP861_16915	COG0584	glycerophosphoryl diester phosphodiesterase
OP861_16920	COG2991	Protein conserved in bacteria
OP861_16925	COG1477	protein flavinylation
OP861_16930	COG2871	sodium ion transport
OP861_16935	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OP861_16940	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OP861_16945	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OP861_16950	COG1805	sodium ion transport
OP861_16960	COG3034	peptidoglycan biosynthetic process
OP861_16965	COG0121	glutamine amidotransferase
OP861_16970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OP861_16975	COG1960	acyl-CoA dehydrogenase activity
OP861_16980	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
OP861_16995	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
OP861_17005	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
OP861_17015	COG0235	Class ii aldolase
OP861_17020	COG0436	Aminotransferase
OP861_17035	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OP861_17045	COG2814	Major facilitator Superfamily
OP861_17050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OP861_17060	COG1846	Transcriptional regulator
OP861_17070	COG1566	PFAM secretion protein HlyD family protein
OP861_17075	COG2814	Major facilitator Superfamily
OP861_17080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OP861_17085	COG3118	belongs to the thioredoxin family
OP861_17090	COG3148	PFAM DTW domain containing protein
OP861_17095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OP861_17095	COG1042	CoA-binding domain protein
OP861_17095	COG0045	succinate-CoA ligase (ADP-forming) activity
OP861_17100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OP861_17105	COG5544	Lipoprotein
OP861_17135	COG0542	response to heat
OP861_17145	COG0564	pseudouridine synthase activity
OP861_17150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OP861_17155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OP861_17160	COG0077	Prephenate dehydratase
OP861_17160	COG1605	Chorismate mutase
OP861_17165	COG0287	Prephenate dehydrogenase
OP861_17165	COG1605	Chorismate mutase
OP861_17170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OP861_17175	COG3279	Response regulator of the LytR AlgR family
OP861_17180	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
OP861_17185	COG3137	Salt-induced outer membrane protein
OP861_17190	COG0335	large ribosomal subunit rRNA binding
OP861_17195	COG0336	Belongs to the RNA methyltransferase TrmD family
OP861_17205	COG0228	four-way junction DNA binding
OP861_17210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OP861_17215	COG4137	Cytochrome C assembly protein
OP861_17220	COG4536	flavin adenine dinucleotide binding
OP861_17225	COG1854	S-ribosylhomocysteine lyase activity
OP861_17230	COG2918	glutathione biosynthetic process
OP861_17235	COG1238	metal cluster binding
OP861_17240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OP861_17270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
OP861_17275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OP861_17280	COG2137	regulation of response to DNA damage stimulus
OP861_17285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OP861_17310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OP861_17315	COG3958	Transketolase
OP861_17320	COG3959	Transketolase, thiamine diphosphate binding domain
OP861_17325	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_17330	COG1129	ABC transporter
OP861_17340	COG1879	ABC-type sugar transport system periplasmic component
OP861_17355	COG3381	protein complex oligomerization
OP861_17360	COG3302	dmso reductase anchor subunit
OP861_17365	COG0437	4 iron, 4 sulfur cluster binding
OP861_17370	COG0243	molybdopterin cofactor binding
OP861_17375	COG1454	alcohol dehydrogenase
OP861_17380	COG0235	Class ii aldolase
OP861_17385	COG0738	Major facilitator superfamily
OP861_17395	COG1070	Carbohydrate kinase
OP861_17405	COG1349	DNA-binding transcription factor activity
OP861_17410	COG0235	Class ii aldolase
OP861_17415	COG1349	DNA-binding transcription factor activity
OP861_17425	COG1129	ABC transporter
OP861_17430	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_17435	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_17440	COG3623	hexulose-6-phosphate isomerase
OP861_17445	COG1070	Carbohydrate kinase
OP861_17450	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
OP861_17450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
OP861_17465	COG4177	L-phenylalanine transmembrane transporter activity
OP861_17470	COG1137	ATPase activity
OP861_17475	COG0410	ABC transporter
OP861_17540	COG0640	Transcriptional regulator
OP861_17545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OP861_17550	COG3048	D-serine ammonia-lyase activity
OP861_17555	COG2610	gluconate transmembrane transporter activity
OP861_17560	COG0583	DNA-binding transcription factor activity
OP861_17565	COG4608	Belongs to the ABC transporter superfamily
OP861_17570	COG0444	Belongs to the ABC transporter superfamily
OP861_17575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OP861_17580	COG0601	transmembrane transport
OP861_17585	COG0747	negative chemotaxis
OP861_17590	COG4948	Mandelate Racemase Muconate Lactonizing
OP861_17595	COG1028	Short-chain dehydrogenase reductase Sdr
OP861_17615	COG1538	Outer membrane efflux protein
OP861_17620	COG0577	efflux transmembrane transporter activity
OP861_17620	COG1136	(ABC) transporter
OP861_17625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP861_17640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OP861_17660	COG3539	Fimbrial protein
OP861_17670	COG3121	Chaperone
OP861_17675	COG3188	usher protein
OP861_17700	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OP861_17705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OP861_17710	COG1388	LysM domain
OP861_17710	COG4942	peptidase
OP861_17715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OP861_17720	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OP861_17725	COG0585	pseudouridine synthase activity
OP861_17730	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OP861_17740	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OP861_17750	COG0765	amino acid transport
OP861_17765	COG0529	Catalyzes the synthesis of activated sulfate
OP861_17770	COG2895	sulfate adenylyltransferase (ATP) activity
OP861_17775	COG0175	sulfate reduction
OP861_17780	COG1648	precorrin-2 dehydrogenase activity
OP861_17780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OP861_17785	COG2234	aminopeptidase activity
OP861_17800	COG0175	sulfate reduction
OP861_17805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OP861_17810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OP861_17815	COG0720	synthase
OP861_17820	COG0602	queuosine metabolic process
OP861_17830	COG0148	phosphopyruvate hydratase activity
OP861_17835	COG0504	CTP synthase activity
OP861_17840	COG3956	TIGRFAM MazG family protein
OP861_17845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OP861_17850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OP861_17860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OP861_17865	COG0232	Belongs to the dGTPase family. Type 2 subfamily
OP861_17870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OP861_17880	COG2860	membrane
OP861_17885	COG0316	Belongs to the HesB IscA family
OP861_17895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OP861_17905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OP861_17910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OP861_17915	COG1120	ATPase activity
OP861_17920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OP861_17930	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
OP861_17935	COG1489	DNA binding
OP861_17945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OP861_17950	COG0617	tRNA 3'-terminal CCA addition
OP861_17955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OP861_17960	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OP861_17965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OP861_17975	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OP861_17980	COG0726	polysaccharide deacetylase
OP861_17985	COG0842	Transport permease protein
OP861_17990	COG1131	(ABC) transporter
OP861_17995	COG0288	reversible hydration of carbon dioxide
OP861_18000	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
OP861_18005	COG2132	Multicopper oxidase
OP861_18015	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
OP861_18020	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
OP861_18030	COG3112	Uncharacterised protein family (UPF0231)
OP861_18035	COG1049	propionate catabolic process, 2-methylcitrate cycle
OP861_18050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OP861_18055	COG0508	dehydrogenase complex catalyzes the overall conversion of
OP861_18060	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
OP861_18065	COG2186	Transcriptional regulator
OP861_18070	COG1113	amino acid transport
OP861_18075	COG3725	Membrane protein required for beta-lactamase induction
OP861_18090	COG4969	Belongs to the N-Me-Phe pilin family
OP861_18095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OP861_18100	COG1459	type II secretion system
OP861_18105	COG0516	GMP reductase activity
OP861_18120	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
OP861_18125	COG0494	nUDIX hydrolase
OP861_18130	COG0653	protein targeting
OP861_18150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OP861_18155	COG0849	cell division
OP861_18160	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OP861_18170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OP861_18175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OP861_18180	COG0772	Belongs to the SEDS family
OP861_18190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OP861_18195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OP861_18200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OP861_18205	COG0768	penicillin binding
OP861_18210	COG3116	cell division
OP861_18215	COG0275	rRNA processing
OP861_18240	COG0028	Belongs to the TPP enzyme family
OP861_18245	COG1022	Amp-dependent synthetase and ligase
OP861_18255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OP861_18260	COG0473	3-isopropylmalate dehydrogenase activity
OP861_18265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OP861_18280	COG3033	Beta-eliminating lyase
OP861_18285	COG0814	amino acid
OP861_18290	COG2814	Major facilitator Superfamily
OP861_18295	COG1882	Formate acetyltransferase
OP861_18300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OP861_18305	COG4533	DNA binding
OP861_18310	COG4143	(ABC) transporter
OP861_18315	COG1178	ABC-type Fe3 transport system permease component
OP861_18325	COG0586	Pfam SNARE associated Golgi protein
OP861_18330	COG0417	DNA replication proofreading
OP861_18335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OP861_18340	COG0564	pseudouridine synthase activity
OP861_18345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
OP861_18350	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OP861_18365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OP861_18370	COG2967	ApaG domain
OP861_18375	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OP861_18380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OP861_18390	COG2966	Psort location CytoplasmicMembrane, score
OP861_18395	COG1280	lysine exporter protein (LysE YggA)
OP861_18400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OP861_18410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OP861_18415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OP861_18420	COG1047	Peptidyl-prolyl cis-trans
OP861_18425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OP861_18430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OP861_18435	COG0196	riboflavin kinase activity
OP861_18445	COG0583	DNA-binding transcription factor activity
OP861_18450	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OP861_18455	COG0484	heat shock protein binding
OP861_18465	COG1584	GPR1 FUN34 yaaH family protein
OP861_18480	COG0521	Mo-molybdopterin cofactor biosynthetic process
OP861_18485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OP861_18490	COG3022	response to hydroperoxide
OP861_18500	COG0083	homoserine kinase activity
OP861_18520	COG0745	RESPONSE REGULATOR receiver
OP861_18525	COG3045	CreA protein
OP861_18530	COG3708	Transcriptional regulator
OP861_18530	COG2207	Transcriptional regulator
OP861_18540	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
OP861_18545	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
OP861_18550	COG0741	lytic transglycosylase activity
OP861_18555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OP861_18565	COG2199	diguanylate cyclase activity
OP861_18570	COG2885	chlorophyll binding
OP861_18575	COG0488	(ABC) transporter
OP861_18610	COG1454	alcohol dehydrogenase
OP861_18625	COG0604	alcohol dehydrogenase
OP861_18640	COG0560	Phosphoserine phosphatase
OP861_18645	COG3726	membrane protein affecting hemolysin expression
OP861_18650	COG3550	peptidyl-serine autophosphorylation
OP861_18660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
OP861_18665	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
OP861_18675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OP861_18680	COG0084	hydrolase, TatD family'
OP861_18695	COG2823	Periplasmic or secreted lipoprotein
OP861_18700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OP861_18705	COG0456	acetyltransferase
OP861_18710	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
OP861_18720	COG0667	Aldo Keto reductase
OP861_18810	COG2192	nodulation
OP861_18820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OP861_18820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OP861_18820	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
OP861_18825	COG1461	Dihydroxyacetone kinase
OP861_18830	COG2376	Dihydroxyacetone kinase
OP861_18840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OP861_18845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OP861_18850	COG2235	arginine
OP861_18865	COG0859	PFAM glycosyl transferase family 9
OP861_18870	COG1070	Carbohydrate kinase
OP861_18875	COG2390	Transcriptional regulator
OP861_18880	COG1129	ABC transporter
OP861_18885	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_18890	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_18895	COG1879	ABC-type sugar transport system periplasmic component
OP861_18900	COG1830	Aldolase
OP861_18910	COG0642	Histidine kinase
OP861_18935	COG3272	Protein of unknown function (DUF1722)
OP861_18965	COG2831	hemolysin activation secretion protein
OP861_18970	COG3210	domain, Protein
OP861_18985	COG3210	domain, Protein
OP861_19015	COG0270	DNA (cytosine-5-)-methyltransferase activity
OP861_19030	COG0795	lipopolysaccharide-transporting ATPase activity
OP861_19035	COG0795	lipopolysaccharide-transporting ATPase activity
OP861_19040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OP861_19045	COG2927	DNA polymerase III (CHI subunit)
OP861_19060	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
OP861_19070	COG2731	YhcH YjgK YiaL family protein
OP861_19080	COG0601	transmembrane transport
OP861_19085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OP861_19090	COG0444	Belongs to the ABC transporter superfamily
OP861_19095	COG4608	Belongs to the ABC transporter superfamily
OP861_19105	COG2249	NAD(P)H dehydrogenase (quinone) activity
OP861_19110	COG0583	DNA-binding transcription factor activity
OP861_19125	COG2188	Transcriptional regulator
OP861_19130	COG3624	Phosphonate C-P lyase system protein PhnG
OP861_19135	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
OP861_19140	COG3626	phosphonate metabolism
OP861_19145	COG3627	carbon phosphorus lyase activity
OP861_19150	COG4107	phosphonate C-P lyase system protein PhnK
OP861_19155	COG4778	phosphonate C-P lyase system protein PhnL
OP861_19160	COG3454	Phosphonate metabolism
OP861_19165	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
OP861_19170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
OP861_19175	COG0702	epimerase
OP861_19180	COG3787	Belongs to the UPF0306 family
OP861_19190	COG1982	Orn Lys Arg decarboxylase major
OP861_19195	COG0531	amino acid
OP861_19200	COG2827	Endonuclease containing a URI domain
OP861_19205	COG3153	acetyltransferase
OP861_19210	COG3154	lipid carrier protein
OP861_19215	COG0826	peptidase U32
OP861_19220	COG0826	peptidase U32
OP861_19225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OP861_19230	COG0513	Belongs to the DEAD box helicase family
OP861_19240	COG1185	polyribonucleotide nucleotidyltransferase activity
OP861_19250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OP861_19255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OP861_19265	COG0195	Participates in both transcription termination and antitermination
OP861_19285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OP861_19295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OP861_19305	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
OP861_19310	COG1534	Rna-binding protein
OP861_19320	COG2027	D-alanyl-D-alanine carboxypeptidase
OP861_19325	COG0745	RESPONSE REGULATOR receiver
OP861_19330	COG0642	Histidine kinase
OP861_19335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OP861_19340	COG0697	spore germination
OP861_19355	COG0142	geranyltranstransferase activity
OP861_19370	COG3423	Transcriptional regulator
OP861_19395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OP861_19400	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
OP861_19405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OP861_19410	COG2105	PFAM AIG2 family protein
OP861_19420	COG0729	surface antigen
OP861_19425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OP861_19430	COG1253	flavin adenine dinucleotide binding
OP861_19440	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
OP861_19445	COG1218	3'(2'),5'-bisphosphate nucleotidase
OP861_19450	COG0737	Belongs to the 5'-nucleotidase family
OP861_19460	COG0545	Peptidyl-prolyl cis-trans isomerase
OP861_19465	COG3061	Opacity-associated protein A
OP861_19475	COG0359	binds to the 23S rRNA
OP861_19480	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OP861_19485	COG2965	DNA replication, synthesis of RNA primer
OP861_19490	COG0360	Binds together with S18 to 16S ribosomal RNA
OP861_19500	COG1073	alpha beta
OP861_19505	COG3650	response to hydrogen peroxide
OP861_19510	COG1960	acyl-CoA dehydrogenase activity
OP861_19515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OP861_19520	COG0557	exoribonuclease II activity
OP861_19525	COG1959	2 iron, 2 sulfur cluster binding
OP861_19530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OP861_19535	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
OP861_19540	COG0330	HflC and HflK could
OP861_19545	COG0330	HflC and HflK could
OP861_19550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OP861_19560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OP861_19565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OP861_19570	COG0860	N-Acetylmuramoyl-L-alanine amidase
OP861_19575	COG0802	atpase or kinase
OP861_19580	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OP861_19580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OP861_19585	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OP861_19605	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OP861_19610	COG1162	GTPase activity
OP861_19615	COG0688	phosphatidylethanolamine metabolic process
OP861_19620	COG1511	domain protein
OP861_19620	COG3264	Mechanosensitive ion channel
OP861_19625	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OP861_19630	COG1053	succinate dehydrogenase
OP861_19635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OP861_19640	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
OP861_19645	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
OP861_19680	COG0459	protein refolding
OP861_19685	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OP861_19710	COG4232	protein-disulfide reductase activity
OP861_19715	COG3383	formate dehydrogenase (NAD+) activity
OP861_19720	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP861_19725	COG0493	'glutamate synthase
OP861_19725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OP861_19730	COG2271	Major facilitator Superfamily
OP861_19735	COG2721	sulfolactate sulfo-lyase activity
OP861_19740	COG3835	regulator
OP861_19745	COG1929	Belongs to the glycerate kinase type-1 family
OP861_19750	COG2084	Dehydrogenase
OP861_19760	COG1309	transcriptional regulator
OP861_19770	COG3876	Protein conserved in bacteria
OP861_19780	COG1472	Belongs to the glycosyl hydrolase 3 family
OP861_19790	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OP861_19795	COG1263	PTS System
OP861_19795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OP861_19805	COG0840	transmembrane signaling receptor activity
OP861_19810	COG1882	Formate acetyltransferase
OP861_19815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OP861_19820	COG0814	amino acid
OP861_19825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OP861_19830	COG0488	(ABC) transporter
OP861_19845	COG3720	iron ion transport
OP861_19850	COG4558	Periplasmic binding protein
OP861_19855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OP861_19860	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
OP861_19865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OP861_19875	COG4774	siderophore transport
OP861_19880	COG1511	domain protein
OP861_19880	COG3264	Mechanosensitive ion channel
OP861_20040	COG5002	protein histidine kinase activity
OP861_20040	COG2205	protein histidine kinase activity
OP861_20040	COG0784	Response regulator, receiver
OP861_20050	COG1301	dicarboxylic acid transport
OP861_20055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OP861_20060	COG3162	membrane
OP861_20065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OP861_20100	COG0138	bifunctional purine biosynthesis protein purh
OP861_20105	COG0151	Belongs to the GarS family
OP861_20125	COG1515	deoxyribonuclease V activity
OP861_20130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OP861_20135	COG2816	NAD+ diphosphatase activity
OP861_20140	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
OP861_20155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OP861_20160	COG2104	thiamine diphosphate biosynthetic process
OP861_20165	COG2022	thiamine diphosphate biosynthetic process
OP861_20175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OP861_20180	COG0085	RNA polymerase activity
OP861_20185	COG0222	ribosome binding
OP861_20190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OP861_20195	COG0081	regulation of translation
OP861_20200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OP861_20205	COG0250	Participates in transcription elongation, termination and antitermination
OP861_20245	COG1072	(Pantothenic acid kinase))
OP861_20250	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
OP861_20250	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
OP861_20285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OP861_20290	COG1739	Uncharacterized protein family UPF0029
OP861_20300	COG1024	Enoyl-CoA hydratase
OP861_20300	COG1250	3-hydroxyacyl-CoA dehydrogenase
OP861_20305	COG0183	Belongs to the thiolase family
OP861_20315	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
OP861_20335	COG0805	protein transport
OP861_20340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OP861_20345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OP861_20350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OP861_20355	COG3165	ubiquinone biosynthetic process from chorismate
OP861_20360	COG2226	methyltransferase
OP861_20365	COG1322	Protein conserved in bacteria
OP861_20370	COG0586	Pfam SNARE associated Golgi protein
OP861_20375	COG1966	Carbon starvation protein
OP861_20390	COG0412	Dienelactone hydrolase
OP861_20395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OP861_20400	COG0583	DNA-binding transcription factor activity
OP861_20405	COG0697	spore germination
OP861_20410	COG0679	Auxin Efflux Carrier
OP861_20415	COG0584	glycerophosphoryl diester phosphodiesterase
OP861_20420	COG3842	ATPase activity
OP861_20425	COG0395	ABC-type sugar transport system, permease component
OP861_20430	COG1175	transmembrane transport
OP861_20435	COG1653	transport
OP861_20470	COG0410	ABC transporter
OP861_20480	COG4177	L-phenylalanine transmembrane transporter activity
OP861_20490	COG0683	leucine binding
OP861_20495	COG0456	acetyltransferase
OP861_20505	COG2177	Part of the ABC transporter FtsEX involved in
OP861_20510	COG2884	Cell division ATP-binding protein ftsE
OP861_20515	COG0552	protein localization to endoplasmic reticulum
OP861_20520	COG0742	ribosomal rna small subunit methyltransferase
OP861_20525	COG3776	membrane
OP861_20540	COG3714	YhhN family
OP861_20545	COG2217	Heavy metal translocating P-type atpase
OP861_20550	COG0425	Belongs to the sulfur carrier protein TusA family
OP861_20555	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
OP861_20565	COG0247	lactate metabolic process
OP861_20570	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
OP861_20575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OP861_20585	COG2271	Major facilitator Superfamily
OP861_20590	COG0584	glycerophosphoryl diester phosphodiesterase
OP861_20595	COG0561	phosphatase activity
OP861_20600	COG2267	carboxylic ester hydrolase activity
OP861_20605	COG1280	lysine exporter protein (LysE YggA)
OP861_20610	COG1280	lysine exporter protein (LysE YggA)
OP861_20615	COG0514	ATP-dependent DNA helicase (RecQ)
OP861_20620	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
OP861_20625	COG2050	protein possibly involved in aromatic compounds catabolism
OP861_20645	COG5564	TIM-barrel signal transduction protein
OP861_20650	COG5441	Belongs to the UPF0261 family
OP861_20660	COG0210	DNA helicase
OP861_20665	COG1011	Hydrolase
OP861_20670	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OP861_20675	COG3159	Protein conserved in bacteria
OP861_20680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OP861_20685	COG5567	small periplasmic lipoprotein
OP861_20695	COG3072	Adenylate cyclase
OP861_20700	COG0181	hydroxymethylbilane synthase activity
OP861_20705	COG1587	Uroporphyrinogen-III synthase
OP861_20710	COG2959	enzyme of heme biosynthesis
OP861_20715	COG3071	HemY protein
OP861_20755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OP861_20760	COG2244	polysaccharide biosynthetic process
OP861_20765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OP861_20770	COG0456	acetyltransferase
OP861_20775	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
OP861_20780	COG1088	dTDP-glucose 4,6-dehydratase activity
OP861_20785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OP861_20790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
OP861_20795	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
OP861_20800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OP861_20805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OP861_20810	COG3118	belongs to the thioredoxin family
OP861_20820	COG0248	Ppx GppA phosphatase
OP861_20835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OP861_20845	COG3121	Chaperone
OP861_20860	COG3121	Chaperone
OP861_20920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OP861_20925	COG0583	DNA-binding transcription factor activity
OP861_20935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OP861_20945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OP861_20950	COG3978	acetolactate synthase activity
OP861_20970	COG3085	chromosome segregation
OP861_20975	COG0583	DNA-binding transcription factor activity
OP861_20980	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_20985	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_20990	COG1129	ABC transporter
OP861_20995	COG1879	ABC-type sugar transport system periplasmic component
OP861_21035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OP861_21045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OP861_21060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OP861_21070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OP861_21070	COG0678	peroxiredoxin activity
OP861_21075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OP861_21120	COG1629	transport
OP861_21125	COG0165	Argininosuccinate lyase
OP861_21145	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OP861_21155	COG0527	aspartate kinase activity
OP861_21155	COG0460	homoserine dehydrogenase
OP861_21160	COG0626	cystathionine gamma-synthase activity
OP861_21165	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
OP861_21170	COG0254	rRNA binding
OP861_21175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OP861_21180	COG1609	Transcriptional regulator
OP861_21185	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OP861_21190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
OP861_21195	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OP861_21200	COG1575	Belongs to the MenA family. Type 1 subfamily
OP861_21210	COG3074	FtsZ-dependent cytokinesis
OP861_21215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OP861_21220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OP861_21225	COG1494	fructose-1,6-bisphosphatase
OP861_21230	COG2814	Major facilitator Superfamily
OP861_21240	COG3152	Membrane
OP861_21255	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
OP861_21265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
OP861_21270	COG3678	ATP-independent chaperone mediated protein folding
OP861_21275	COG0745	RESPONSE REGULATOR receiver
OP861_21280	COG2205	protein histidine kinase activity
OP861_21285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OP861_21285	COG2169	Transcriptional regulator
OP861_21290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OP861_21295	COG1045	serine acetyltransferase
OP861_21300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OP861_21305	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
OP861_21310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OP861_21315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OP861_21320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OP861_21325	COG4942	peptidase
OP861_21330	COG2861	carbohydrate metabolic process
OP861_21340	COG0156	8-amino-7-oxononanoate synthase activity
OP861_21345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OP861_21355	COG0859	PFAM glycosyl transferase family 9
OP861_21360	COG1519	Transferase
OP861_21370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OP861_21380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OP861_21385	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OP861_21395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OP861_21400	COG0756	dUTP diphosphatase activity
OP861_21405	COG1309	transcriptional regulator
OP861_21410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OP861_21415	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OP861_21420	COG1561	YicC-like family, N-terminal region
OP861_21425	COG3645	SOS response
OP861_21430	COG1396	sequence-specific DNA binding
OP861_21445	COG5001	Diguanylate cyclase
OP861_21450	COG1024	Enoyl-CoA hydratase
OP861_21455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OP861_21465	COG2860	membrane
OP861_21470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OP861_21480	COG1758	RNA polymerase activity
OP861_21485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OP861_21490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OP861_21495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OP861_21500	COG0786	glutamate:sodium symporter activity
OP861_21505	COG2233	PERMEase
OP861_21510	COG2982	Protein involved in outer membrane biogenesis
OP861_21525	COG3423	Transcriptional regulator
OP861_21540	COG2204	response regulator
OP861_21545	COG0456	acetyltransferase
OP861_21550	COG1490	D-aminoacyl-tRNA deacylase activity
OP861_21555	COG1295	ribonuclease BN
OP861_21560	COG1011	Hydrolase
OP861_21570	COG0174	glutamine synthetase
OP861_21575	COG3852	Histidine kinase
OP861_21585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OP861_21595	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OP861_21600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OP861_21600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OP861_21605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OP861_21610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OP861_21615	COG3084	Protein conserved in bacteria
OP861_21625	COG1763	Mo-molybdopterin cofactor biosynthetic process
OP861_21650	COG2186	Transcriptional regulator
OP861_21655	COG0477	Major facilitator Superfamily
OP861_21660	COG1609	Transcriptional regulator
OP861_21665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OP861_21670	COG1879	ABC-type sugar transport system periplasmic component
OP861_21675	COG1172	Belongs to the binding-protein-dependent transport system permease family
OP861_21685	COG1869	D-ribose catabolic process
OP861_21690	COG3158	transport of potassium into the cell
OP861_21695	COG0714	Associated with various cellular activities
OP861_21700	COG2425	protein containing a von Willebrand factor type A (vWA) domain
OP861_21710	COG2502	aspartate--ammonia ligase
OP861_21715	COG1522	sequence-specific DNA binding
OP861_21720	COG0716	FMN binding
OP861_21725	COG0445	tRNA wobble uridine modification
OP861_21730	COG0357	Ribosomal RNA small subunit methyltransferase G
OP861_21735	COG3312	ion transport
OP861_21740	COG0356	it plays a direct role in the translocation of protons across the membrane
OP861_21750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OP861_21755	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OP861_21760	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OP861_21770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OP861_21775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OP861_21780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OP861_21830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OP861_21835	COG0573	inorganic phosphate transmembrane transporter activity
OP861_21840	COG0581	inorganic phosphate transmembrane transporter activity
OP861_21850	COG0704	Plays a role in the regulation of phosphate uptake
OP861_21860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OP861_21865	COG0765	amino acid transport
OP861_21870	COG0765	amino acid transport
OP861_21875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OP861_21880	COG2252	PERMEase
OP861_21895	COG4191	Histidine kinase
OP861_21900	COG0431	NADPH-dependent FMN reductase
OP861_21905	COG0840	transmembrane signaling receptor activity
OP861_21910	COG2011	ABC-type metal ion transport system permease component
OP861_21915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OP861_21925	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OP861_21930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OP861_21935	COG0706	membrane insertase activity
OP861_21945	COG0594	ribonuclease P activity
OP861_21950	COG0230	Belongs to the bacterial ribosomal protein bL34 family