locus-tag	class	description
CH53_1	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CH53_10	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH53_1001	COG4969	Belongs to the N-Me-Phe pilin family
CH53_1002	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH53_1003	COG1459	type II secretion system
CH53_1004	COG0516	GMP reductase activity
CH53_1005	COG0237	dephospho-CoA kinase activity
CH53_1007	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CH53_1008	COG0494	nUDIX hydrolase
CH53_1009	COG0653	protein targeting
CH53_1013	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH53_1014	COG0849	cell division
CH53_1015	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH53_1017	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH53_1018	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CH53_1019	COG0772	Belongs to the SEDS family
CH53_1021	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH53_1022	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH53_1023	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH53_1024	COG0768	penicillin binding
CH53_1025	COG3116	cell division
CH53_1026	COG0275	rRNA processing
CH53_1029	COG1609	Transcriptional regulator
CH53_103	COG2920	part of a sulfur-relay system
CH53_1031	COG0028	Belongs to the TPP enzyme family
CH53_1032	COG1022	Amp-dependent synthetase and ligase
CH53_1033	COG0583	DNA-binding transcription factor activity
CH53_1035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CH53_1036	COG0473	3-isopropylmalate dehydrogenase activity
CH53_1037	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CH53_104	COG1254	Belongs to the acylphosphatase family
CH53_1040	COG3033	Beta-eliminating lyase
CH53_1041	COG0814	amino acid
CH53_1042	COG2814	Major facilitator Superfamily
CH53_1044	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH53_1045	COG4533	DNA binding
CH53_1046	COG4143	(ABC) transporter
CH53_1047	COG1178	ABC-type Fe3 transport system permease component
CH53_1049	COG0586	Pfam SNARE associated Golgi protein
CH53_1051	COG0417	DNA replication proofreading
CH53_1052	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CH53_1053	COG0564	pseudouridine synthase activity
CH53_1054	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH53_1055	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH53_1056	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH53_1058	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CH53_1059	COG2967	ApaG domain
CH53_106	COG3785	DNA binding
CH53_1060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH53_1061	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH53_1063	COG2966	Psort location CytoplasmicMembrane, score
CH53_1064	COG1280	lysine exporter protein (LysE YggA)
CH53_1065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH53_1066	COG0505	Belongs to the CarA family
CH53_1068	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CH53_1069	COG1047	Peptidyl-prolyl cis-trans
CH53_107	COG1832	CoA-binding protein
CH53_1070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CH53_1071	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CH53_1072	COG0196	riboflavin kinase activity
CH53_1074	COG0583	DNA-binding transcription factor activity
CH53_1075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH53_1076	COG0484	heat shock protein binding
CH53_1078	COG1584	GPR1 FUN34 yaaH family protein
CH53_108	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CH53_1081	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH53_1082	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH53_1083	COG3022	response to hydroperoxide
CH53_1085	COG0083	homoserine kinase activity
CH53_1088	COG0745	RESPONSE REGULATOR receiver
CH53_1089	COG3045	CreA protein
CH53_1091	COG2207	Transcriptional regulator
CH53_1091	COG3708	Transcriptional regulator
CH53_1092	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CH53_1093	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH53_1094	COG0741	lytic transglycosylase activity
CH53_1095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH53_1097	COG2199	diguanylate cyclase activity
CH53_1098	COG2885	chlorophyll binding
CH53_1099	COG0488	(ABC) transporter
CH53_11	COG1399	metal-binding, possibly nucleic acid-binding protein
CH53_110	COG0210	DNA helicase
CH53_1106	COG1454	alcohol dehydrogenase
CH53_1109	COG0604	alcohol dehydrogenase
CH53_111	COG3304	Inner membrane component domain
CH53_1112	COG0560	Phosphoserine phosphatase
CH53_1113	COG3726	membrane protein affecting hemolysin expression
CH53_1114	COG3550	peptidyl-serine autophosphorylation
CH53_1116	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH53_1117	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CH53_1118	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH53_1119	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH53_112	COG1289	transmembrane transporter activity
CH53_1120	COG0084	hydrolase, TatD family'
CH53_1121	COG4667	esterase of the alpha-beta hydrolase superfamily
CH53_1123	COG2823	Periplasmic or secreted lipoprotein
CH53_1124	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CH53_1125	COG0456	acetyltransferase
CH53_1126	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH53_1128	COG0667	Aldo Keto reductase
CH53_113	COG3070	regulator of competence-specific genes
CH53_1134	COG3706	GGDEF domain
CH53_114	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CH53_1146	COG2192	nodulation
CH53_1148	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CH53_1148	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_1148	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH53_1149	COG1461	Dihydroxyacetone kinase
CH53_115	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH53_115	COG2885	chlorophyll binding
CH53_1150	COG2376	Dihydroxyacetone kinase
CH53_1152	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH53_1153	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_1154	COG2235	arginine
CH53_1157	COG0859	PFAM glycosyl transferase family 9
CH53_1158	COG1070	Carbohydrate kinase
CH53_1159	COG2390	Transcriptional regulator
CH53_116	COG3120	sequence-specific DNA binding
CH53_1160	COG1129	ABC transporter
CH53_1161	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_1162	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_1163	COG1879	ABC-type sugar transport system periplasmic component
CH53_1164	COG1830	Aldolase
CH53_1166	COG0642	Histidine kinase
CH53_117	COG1067	ATP-dependent peptidase activity
CH53_1171	COG3272	Protein of unknown function (DUF1722)
CH53_1176	COG3423	Transcriptional regulator
CH53_1177	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH53_118	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH53_1182	COG2831	hemolysin activation secretion protein
CH53_1183	COG3210	domain, Protein
CH53_1185	COG3316	Transposase and inactivated derivatives
CH53_120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH53_1201	COG3121	Chaperone
CH53_1202	COG3188	usher protein
CH53_1204	COG1470	cell adhesion involved in biofilm formation
CH53_1204	COG1388	LysM domain
CH53_121	COG3009	Protein conserved in bacteria
CH53_1215	COG0582	viral genome integration into host DNA
CH53_1216	COG0582	viral genome integration into host DNA
CH53_122	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH53_122	COG3008	intermembrane lipid transfer
CH53_1225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH53_123	COG2995	paraquat-inducible protein a
CH53_1233	COG0582	viral genome integration into host DNA
CH53_1235	COG0795	lipopolysaccharide-transporting ATPase activity
CH53_1236	COG0795	lipopolysaccharide-transporting ATPase activity
CH53_1237	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CH53_1238	COG2927	DNA polymerase III (CHI subunit)
CH53_124	COG0488	(ABC) transporter
CH53_1241	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH53_1243	COG2731	YhcH YjgK YiaL family protein
CH53_1245	COG0601	transmembrane transport
CH53_1247	COG0444	Belongs to the ABC transporter superfamily
CH53_1248	COG4608	Belongs to the ABC transporter superfamily
CH53_1249	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH53_125	COG0116	Belongs to the methyltransferase superfamily
CH53_125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH53_1250	COG0583	DNA-binding transcription factor activity
CH53_1253	COG2188	Transcriptional regulator
CH53_1254	COG3624	Phosphonate C-P lyase system protein PhnG
CH53_1255	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CH53_1256	COG3626	phosphonate metabolism
CH53_1257	COG3627	carbon phosphorus lyase activity
CH53_1258	COG4107	phosphonate C-P lyase system protein PhnK
CH53_1259	COG4778	phosphonate C-P lyase system protein PhnL
CH53_126	COG0633	Ferredoxin
CH53_126	COG3217	Mosc domain protein beta barrel domain protein
CH53_1260	COG3454	Phosphonate metabolism
CH53_1261	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CH53_1262	COG0702	epimerase
CH53_1263	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CH53_1264	COG3787	Belongs to the UPF0306 family
CH53_1265	COG1982	Orn Lys Arg decarboxylase major
CH53_1266	COG0531	amino acid
CH53_1267	COG3153	acetyltransferase
CH53_1268	COG2827	Endonuclease containing a URI domain
CH53_1272	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH53_1273	COG0513	Belongs to the DEAD box helicase family
CH53_1275	COG1185	polyribonucleotide nucleotidyltransferase activity
CH53_1277	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CH53_1278	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CH53_128	COG0167	dihydroorotate dehydrogenase activity
CH53_1280	COG0195	Participates in both transcription termination and antitermination
CH53_1284	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH53_1286	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH53_1287	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CH53_1288	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CH53_1289	COG1534	Rna-binding protein
CH53_129	COG0308	aminopeptidase N
CH53_1290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH53_1291	COG2027	D-alanyl-D-alanine carboxypeptidase
CH53_1292	COG0745	RESPONSE REGULATOR receiver
CH53_1293	COG0642	Histidine kinase
CH53_1294	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CH53_1295	COG0697	spore germination
CH53_1298	COG0142	geranyltranstransferase activity
CH53_13	COG0564	pseudouridine synthase activity
CH53_130	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CH53_1301	COG3423	Transcriptional regulator
CH53_1306	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH53_1308	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CH53_1309	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH53_131	COG0017	Asparaginyl-tRNA synthetase
CH53_1310	COG2105	PFAM AIG2 family protein
CH53_1311	COG2911	Protein conserved in bacteria
CH53_1312	COG0729	surface antigen
CH53_1313	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH53_1314	COG1253	flavin adenine dinucleotide binding
CH53_1316	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH53_1317	COG1218	3'(2'),5'-bisphosphate nucleotidase
CH53_1318	COG0737	Belongs to the 5'-nucleotidase family
CH53_1320	COG0545	Peptidyl-prolyl cis-trans isomerase
CH53_1321	COG3061	Opacity-associated protein A
CH53_1323	COG0359	binds to the 23S rRNA
CH53_1324	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH53_1325	COG0360	Binds together with S18 to 16S ribosomal RNA
CH53_1327	COG1073	alpha beta
CH53_1328	COG3650	response to hydrogen peroxide
CH53_1329	COG1960	acyl-CoA dehydrogenase activity
CH53_133	COG1448	Aminotransferase
CH53_1330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH53_1331	COG0557	exoribonuclease II activity
CH53_1332	COG1959	2 iron, 2 sulfur cluster binding
CH53_1333	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CH53_1334	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH53_1335	COG0330	HflC and HflK could
CH53_1336	COG0330	HflC and HflK could
CH53_1337	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH53_1339	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CH53_134	COG2200	EAL domain
CH53_1340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CH53_1341	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH53_1342	COG0802	atpase or kinase
CH53_1343	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH53_1343	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH53_1344	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH53_1348	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH53_1349	COG1162	GTPase activity
CH53_135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH53_1350	COG0688	phosphatidylethanolamine metabolic process
CH53_1351	COG3264	Mechanosensitive ion channel
CH53_1351	COG1511	domain protein
CH53_1352	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CH53_1353	COG1053	succinate dehydrogenase
CH53_1354	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH53_1355	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH53_1356	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH53_1358	COG2076	Multidrug Resistance protein
CH53_136	COG3108	Peptidase M15
CH53_1364	COG0459	protein refolding
CH53_1365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CH53_1368	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH53_137	COG2989	Protein conserved in bacteria
CH53_1370	COG4232	protein-disulfide reductase activity
CH53_1371	COG3383	formate dehydrogenase (NAD+) activity
CH53_1372	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_1373	COG0493	'glutamate synthase
CH53_1373	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_1374	COG2271	Major facilitator Superfamily
CH53_1375	COG2721	sulfolactate sulfo-lyase activity
CH53_1376	COG3835	regulator
CH53_1377	COG1929	Belongs to the glycerate kinase type-1 family
CH53_1378	COG2084	Dehydrogenase
CH53_138	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CH53_1380	COG1309	transcriptional regulator
CH53_1382	COG3876	Protein conserved in bacteria
CH53_1384	COG1472	Belongs to the glycosyl hydrolase 3 family
CH53_1386	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CH53_1387	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_1387	COG1263	PTS System
CH53_1389	COG0840	transmembrane signaling receptor activity
CH53_139	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CH53_1390	COG1882	Formate acetyltransferase
CH53_1391	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH53_1392	COG0814	amino acid
CH53_1394	COG0488	(ABC) transporter
CH53_1397	COG3720	iron ion transport
CH53_1398	COG4558	Periplasmic binding protein
CH53_1399	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH53_14	COG1530	ribonuclease E activity
CH53_140	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH53_1400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH53_1402	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH53_1404	COG4774	siderophore transport
CH53_1405	COG1511	domain protein
CH53_1405	COG3264	Mechanosensitive ion channel
CH53_141	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH53_142	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CH53_143	COG3173	Aminoglycoside phosphotransferase
CH53_1438	COG1301	dicarboxylic acid transport
CH53_1439	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CH53_1440	COG3162	membrane
CH53_1441	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH53_1448	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH53_1449	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH53_145	COG2835	tetraacyldisaccharide 4'-kinase activity
CH53_1450	COG0009	L-threonylcarbamoyladenylate synthase
CH53_1451	COG0551	DNA topoisomerase type I activity
CH53_1453	COG0758	DNA mediated transformation
CH53_1454	COG0242	peptide deformylase activity
CH53_1455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH53_1456	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CH53_1456	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH53_1457	COG0569	domain protein
CH53_1458	COG1970	mechanosensitive ion channel activity
CH53_1459	COG3036	rescue of stalled ribosome
CH53_146	COG1278	Cold shock
CH53_1460	COG0789	Transcriptional regulator
CH53_1462	COG0203	ribosomal protein L17
CH53_1464	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH53_1465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CH53_1466	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CH53_1467	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH53_1468	COG0201	protein transport
CH53_1469	COG0200	Binds to the 23S rRNA
CH53_147	COG1278	Cold shock
CH53_1470	COG1841	ribosomal large subunit assembly
CH53_1471	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CH53_1472	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CH53_1473	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CH53_1474	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CH53_1475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CH53_1477	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CH53_1478	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH53_1479	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH53_1480	COG0255	Belongs to the universal ribosomal protein uL29 family
CH53_1481	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH53_1482	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CH53_1484	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH53_1486	COG0089	rRNA binding
CH53_1489	COG0051	transcription antitermination factor activity, RNA binding
CH53_149	COG5383	Protein conserved in bacteria
CH53_1492	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CH53_1494	COG0049	tRNA binding
CH53_1495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH53_1496	COG2168	tRNA wobble position uridine thiolation
CH53_1497	COG2923	Belongs to the DsrF TusC family
CH53_1498	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH53_1499	COG2964	Protein conserved in bacteria
CH53_15	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH53_150	COG1663	tetraacyldisaccharide 4'-kinase activity
CH53_1500	COG0545	Peptidyl-prolyl cis-trans isomerase
CH53_1502	COG1047	Peptidyl-prolyl cis-trans
CH53_1503	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH53_1505	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH53_1506	COG0488	(ABC) transporter
CH53_1507	COG1216	Glycosyl transferase, family 2
CH53_1508	COG2175	clavaminate synthase activity
CH53_1510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH53_1512	COG4521	taurine ABC transporter
CH53_1515	COG0429	hydrolase of the alpha beta-hydrolase fold
CH53_1517	COG3954	Phosphoribulokinase
CH53_1518	COG1765	OsmC-like protein
CH53_152	COG2333	competence protein COMEC
CH53_152	COG0658	competence protein
CH53_1520	COG1289	transmembrane transporter activity
CH53_1525	COG0433	COG0433 Predicted ATPase
CH53_1526	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH53_1527	COG1486	melibiose metabolic process
CH53_153	COG0776	regulation of translation
CH53_1531	COG0738	Major facilitator superfamily
CH53_1532	COG0402	S-adenosylhomocysteine deaminase activity
CH53_1533	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH53_1534	COG2146	nitrite reductase [NAD(P)H] activity
CH53_1536	COG1648	precorrin-2 dehydrogenase activity
CH53_1536	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH53_1537	COG0180	Tryptophanyl-tRNA synthetase
CH53_1539	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH53_154	COG0539	negative regulation of cytoplasmic translation
CH53_1543	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH53_1544	COG4796	Type ii and iii secretion system protein
CH53_1549	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH53_1550	COG0494	nUDIX hydrolase
CH53_1552	COG1011	Hydrolase
CH53_1553	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH53_1558	COG0745	RESPONSE REGULATOR receiver
CH53_1559	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH53_156	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CH53_1560	COG2183	response to ionizing radiation
CH53_1561	COG1918	ferrous iron import across plasma membrane
CH53_1565	COG0596	Alpha beta hydrolase
CH53_1567	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CH53_1567	COG0316	Belongs to the HesB IscA family
CH53_1568	COG1640	4-alpha-glucanotransferase
CH53_1569	COG0058	SHG alpha-glucan phosphorylase activity
CH53_1570	COG2909	trisaccharide binding
CH53_1572	COG0705	Rhomboid family
CH53_1573	COG1349	DNA-binding transcription factor activity
CH53_1575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH53_1576	COG0058	SHG alpha-glucan phosphorylase activity
CH53_1577	COG0297	glycogen (starch) synthase activity
CH53_1578	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH53_1579	COG1523	belongs to the glycosyl hydrolase 13 family
CH53_158	COG0252	asparaginase activity
CH53_1580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CH53_1581	COG3275	phosphorelay sensor kinase activity
CH53_1585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH53_1586	COG2095	MarC family integral membrane protein
CH53_1587	COG3265	gluconokinase activity
CH53_1588	COG2610	gluconate transmembrane transporter activity
CH53_1589	COG1609	Transcriptional regulator
CH53_159	COG1944	ATP diphosphatase activity
CH53_1590	COG1741	Belongs to the pirin family
CH53_1591	COG1247	-acetyltransferase
CH53_1592	COG1082	Xylose isomerase domain protein TIM barrel
CH53_1593	COG0673	inositol 2-dehydrogenase activity
CH53_1594	COG3962	Belongs to the TPP enzyme family
CH53_1597	COG3718	enzyme involved in inositol metabolism
CH53_16	COG0418	dihydroorotase activity
CH53_160	COG2116	formate transmembrane transporter activity
CH53_1600	COG2814	Major facilitator Superfamily
CH53_1601	COG0583	DNA-binding transcription factor activity
CH53_1604	COG2081	HI0933 family
CH53_1605	COG0306	phosphate transporter
CH53_1607	COG0589	response to stress
CH53_1609	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CH53_161	COG1882	Formate acetyltransferase
CH53_1610	COG0742	ribosomal rna small subunit methyltransferase
CH53_1612	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH53_1613	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH53_1616	COG1295	ribonuclease BN
CH53_1617	COG2134	cdp-diacylglycerol pyrophosphatase
CH53_1618	COG2982	Protein involved in outer membrane biogenesis
CH53_1619	COG2200	EAL domain
CH53_162	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH53_1620	COG1942	4-Oxalocrotonate Tautomerase
CH53_1621	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH53_1622	COG0612	Peptidase, M16
CH53_1623	COG1301	dicarboxylic acid transport
CH53_1626	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH53_1628	COG3188	usher protein
CH53_1629	COG3121	Chaperone
CH53_163	COG2814	Major facilitator Superfamily
CH53_1631	COG2200	EAL domain
CH53_1631	COG2199	diguanylate cyclase activity
CH53_1632	COG3118	belongs to the thioredoxin family
CH53_1632	COG0457	Tetratricopeptide repeat
CH53_1633	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CH53_1634	COG1215	transferase activity, transferring glycosyl groups
CH53_1636	COG1192	Involved in chromosome partitioning
CH53_164	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CH53_1640	COG2194	sulfuric ester hydrolase activity
CH53_1641	COG4608	Belongs to the ABC transporter superfamily
CH53_1642	COG0444	Belongs to the ABC transporter superfamily
CH53_1643	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH53_1644	COG0601	transmembrane transport
CH53_1645	COG0747	negative chemotaxis
CH53_1648	COG2271	Major facilitator Superfamily
CH53_1649	COG3851	Histidine kinase
CH53_165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH53_1650	COG2197	response regulator
CH53_1651	COG2194	sulfuric ester hydrolase activity
CH53_1652	COG1764	response to oxidative stress
CH53_1656	COG2986	histidine ammonia-lyase
CH53_1657	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CH53_166	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CH53_1661	COG1609	Transcriptional regulator
CH53_1661	COG2207	Transcriptional regulator
CH53_1662	COG4214	carbohydrate transport
CH53_1664	COG4213	ABC transporter substrate-binding protein
CH53_1665	COG2115	Belongs to the xylose isomerase family
CH53_1666	COG1070	Carbohydrate kinase
CH53_1668	COG3121	Chaperone
CH53_1669	COG3188	usher protein
CH53_167	COG3107	peptidoglycan biosynthetic process
CH53_167	COG1674	ftsk spoiiie
CH53_1671	COG1335	isochorismatase
CH53_1672	COG3274	enterobacterial common antigen metabolic process
CH53_1675	COG3276	selenocysteine insertion sequence binding
CH53_1676	COG1921	L-seryl-tRNASec selenium transferase activity
CH53_1677	COG3058	Necessary for formate dehydrogenase activity
CH53_1678	COG2864	formate dehydrogenase
CH53_1679	COG0437	4 iron, 4 sulfur cluster binding
CH53_1680	COG3383	formate dehydrogenase (NAD+) activity
CH53_1680	COG0243	molybdopterin cofactor binding
CH53_1681	COG3383	formate dehydrogenase (NAD+) activity
CH53_1681	COG0243	molybdopterin cofactor binding
CH53_1682	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CH53_1683	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH53_1684	COG0840	transmembrane signaling receptor activity
CH53_1685	COG2258	MOSC domain
CH53_1686	COG3077	Addiction module antitoxin, RelB DinJ family
CH53_1689	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH53_1691	COG3722	fumarate hydratase activity
CH53_1692	COG0246	Mannitol dehydrogenase
CH53_1693	COG2213	PTS system mannitol-specific
CH53_1693	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_1695	COG0751	glycine-tRNA ligase activity
CH53_1697	COG2818	Glycosylase
CH53_1698	COG0456	acetyltransferase
CH53_170	COG0492	ferredoxin-NADP+ reductase activity
CH53_1701	COG2885	chlorophyll binding
CH53_1705	COG0366	Alpha amylase catalytic
CH53_1706	COG3977	Valine--pyruvate aminotransferase
CH53_1710	COG5645	(Lipo)protein
CH53_1711	COG0823	Involved in the tonB-independent uptake of proteins
CH53_1712	COG2271	Major facilitator Superfamily
CH53_1713	COG4948	Mandelate Racemase Muconate Lactonizing
CH53_1714	COG0800	Aldolase
CH53_1715	COG3734	2-keto-3-deoxy-galactonokinase
CH53_1716	COG2186	Transcriptional regulator
CH53_1719	COG2423	ornithine cyclodeaminase activity
CH53_172	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH53_1720	COG2188	Transcriptional regulator
CH53_1721	COG2723	6-phospho-beta-galactosidase activity
CH53_1723	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH53_1724	COG1940	carbohydrate kinase activity
CH53_1726	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH53_1727	COG0561	phosphatase activity
CH53_1728	COG0187	DNA topoisomerase II activity
CH53_1730	COG0592	DNA-directed DNA polymerase activity
CH53_1731	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH53_1732	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH53_1733	COG0594	ribonuclease P activity
CH53_1735	COG0706	membrane insertase activity
CH53_1736	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CH53_1737	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CH53_1739	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CH53_174	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH53_1740	COG2011	ABC-type metal ion transport system permease component
CH53_1741	COG0840	transmembrane signaling receptor activity
CH53_1742	COG0431	NADPH-dependent FMN reductase
CH53_1743	COG4191	Histidine kinase
CH53_1746	COG2252	PERMEase
CH53_1747	COG0765	amino acid transport
CH53_1748	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH53_175	COG0542	response to heat
CH53_1750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_1752	COG0704	Plays a role in the regulation of phosphate uptake
CH53_1754	COG0581	inorganic phosphate transmembrane transporter activity
CH53_1755	COG0573	inorganic phosphate transmembrane transporter activity
CH53_1756	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH53_176	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CH53_1766	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CH53_1767	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CH53_1768	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CH53_1769	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CH53_177	COG1278	Cold shock
CH53_1771	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CH53_1772	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CH53_1773	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CH53_1775	COG0356	it plays a direct role in the translocation of protons across the membrane
CH53_1776	COG3312	ion transport
CH53_1777	COG0357	Ribosomal RNA small subunit methyltransferase G
CH53_1778	COG0445	tRNA wobble uridine modification
CH53_1779	COG0716	FMN binding
CH53_1780	COG1522	sequence-specific DNA binding
CH53_1781	COG2502	aspartate--ammonia ligase
CH53_1782	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CH53_1784	COG0714	Associated with various cellular activities
CH53_1785	COG3158	transport of potassium into the cell
CH53_1786	COG1869	D-ribose catabolic process
CH53_1788	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_1789	COG1879	ABC-type sugar transport system periplasmic component
CH53_179	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_1790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH53_1791	COG0477	Major facilitator Superfamily
CH53_1792	COG1609	Transcriptional regulator
CH53_1793	COG2186	Transcriptional regulator
CH53_1798	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH53_180	COG2990	Protein conserved in bacteria
CH53_1800	COG3084	Protein conserved in bacteria
CH53_1801	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH53_1802	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH53_1803	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH53_1803	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH53_1804	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CH53_1806	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH53_1808	COG3852	Histidine kinase
CH53_1809	COG0174	glutamine synthetase
CH53_181	COG3593	DNA synthesis involved in DNA repair
CH53_1811	COG1011	Hydrolase
CH53_1812	COG1295	ribonuclease BN
CH53_1813	COG1490	D-aminoacyl-tRNA deacylase activity
CH53_1814	COG0456	acetyltransferase
CH53_1815	COG2204	response regulator
CH53_1818	COG3423	Transcriptional regulator
CH53_182	COG2431	L-lysine efflux transmembrane transporter activity
CH53_1821	COG2982	Protein involved in outer membrane biogenesis
CH53_1822	COG2233	PERMEase
CH53_1823	COG0786	glutamate:sodium symporter activity
CH53_1824	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH53_1825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH53_1826	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH53_1827	COG1758	RNA polymerase activity
CH53_1829	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH53_183	COG1151	hydroxylamine reductase activity
CH53_1830	COG2860	membrane
CH53_1832	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH53_1833	COG1024	Enoyl-CoA hydratase
CH53_1834	COG5001	Diguanylate cyclase
CH53_184	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH53_185	COG0028	Belongs to the TPP enzyme family
CH53_1851	COG1561	YicC-like family, N-terminal region
CH53_1852	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CH53_1853	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CH53_1854	COG1309	transcriptional regulator
CH53_1855	COG0756	dUTP diphosphatase activity
CH53_1856	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH53_1858	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CH53_1859	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH53_1861	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CH53_1863	COG1519	Transferase
CH53_1865	COG0859	PFAM glycosyl transferase family 9
CH53_1866	COG0859	PFAM glycosyl transferase family 9
CH53_1867	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH53_1868	COG0156	8-amino-7-oxononanoate synthase activity
CH53_187	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH53_1870	COG2861	carbohydrate metabolic process
CH53_1871	COG4942	peptidase
CH53_1872	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CH53_1873	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH53_1874	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH53_1875	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CH53_1876	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CH53_1877	COG1045	serine acetyltransferase
CH53_1878	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH53_1879	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH53_1879	COG2169	Transcriptional regulator
CH53_188	COG0702	epimerase
CH53_1880	COG2205	protein histidine kinase activity
CH53_1881	COG0745	RESPONSE REGULATOR receiver
CH53_1882	COG3678	ATP-independent chaperone mediated protein folding
CH53_1884	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CH53_1886	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CH53_1888	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH53_189	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH53_1891	COG3152	Membrane
CH53_1893	COG2814	Major facilitator Superfamily
CH53_1894	COG1494	fructose-1,6-bisphosphatase
CH53_1895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH53_1896	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH53_1897	COG3074	FtsZ-dependent cytokinesis
CH53_1899	COG1575	Belongs to the MenA family. Type 1 subfamily
CH53_1900	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CH53_1901	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CH53_1902	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH53_1903	COG1609	Transcriptional regulator
CH53_1904	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH53_1905	COG0254	rRNA binding
CH53_1906	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CH53_1907	COG0626	cystathionine gamma-synthase activity
CH53_1908	COG0527	aspartate kinase activity
CH53_1908	COG0460	homoserine dehydrogenase
CH53_191	COG1126	abc transporter atp-binding protein
CH53_1910	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CH53_1913	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CH53_1915	COG0165	Argininosuccinate lyase
CH53_192	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_1926	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH53_1927	COG0678	peroxiredoxin activity
CH53_1927	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH53_1928	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH53_193	COG4215	(ABC) transporter
CH53_1932	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH53_1934	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CH53_194	COG4160	amino acid transport
CH53_1943	COG1879	ABC-type sugar transport system periplasmic component
CH53_1944	COG1129	ABC transporter
CH53_1945	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_1946	COG0583	DNA-binding transcription factor activity
CH53_1947	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_1948	COG3085	chromosome segregation
CH53_195	COG1414	Transcriptional regulator
CH53_1951	COG3978	acetolactate synthase activity
CH53_1952	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH53_1954	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH53_1956	COG0583	DNA-binding transcription factor activity
CH53_1957	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CH53_1959	COG3121	Chaperone
CH53_196	COG1012	belongs to the aldehyde dehydrogenase family
CH53_1962	COG3121	Chaperone
CH53_1965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH53_1968	COG0248	Ppx GppA phosphatase
CH53_197	COG1454	alcohol dehydrogenase
CH53_1970	COG3118	belongs to the thioredoxin family
CH53_1971	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH53_1972	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH53_1973	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH53_1974	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH53_1975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH53_1976	COG1088	dTDP-glucose 4,6-dehydratase activity
CH53_1977	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH53_1978	COG0456	acetyltransferase
CH53_1979	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH53_198	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH53_1980	COG2244	polysaccharide biosynthetic process
CH53_1981	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH53_1984	COG1113	amino acid transport
CH53_1989	COG3071	HemY protein
CH53_199	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_1990	COG2959	enzyme of heme biosynthesis
CH53_1991	COG1587	Uroporphyrinogen-III synthase
CH53_1992	COG0181	hydroxymethylbilane synthase activity
CH53_1993	COG3072	Adenylate cyclase
CH53_1995	COG5567	small periplasmic lipoprotein
CH53_1996	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CH53_1997	COG3159	Protein conserved in bacteria
CH53_1998	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH53_1999	COG1011	Hydrolase
CH53_2	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH53_2000	COG0210	DNA helicase
CH53_2002	COG5441	Belongs to the UPF0261 family
CH53_2003	COG5564	TIM-barrel signal transduction protein
CH53_2005	COG0598	Magnesium transport protein CorA
CH53_2007	COG2050	protein possibly involved in aromatic compounds catabolism
CH53_2008	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CH53_2009	COG0514	ATP-dependent DNA helicase (RecQ)
CH53_2010	COG1280	lysine exporter protein (LysE YggA)
CH53_2011	COG1280	lysine exporter protein (LysE YggA)
CH53_2012	COG2267	carboxylic ester hydrolase activity
CH53_2013	COG0561	phosphatase activity
CH53_2014	COG0584	glycerophosphoryl diester phosphodiesterase
CH53_2015	COG2271	Major facilitator Superfamily
CH53_2016	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH53_2017	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CH53_2018	COG0247	lactate metabolic process
CH53_202	COG1177	transmembrane transport
CH53_2020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH53_2021	COG0425	Belongs to the sulfur carrier protein TusA family
CH53_2022	COG2217	Heavy metal translocating P-type atpase
CH53_2023	COG3714	YhhN family
CH53_2026	COG3776	membrane
CH53_2027	COG0742	ribosomal rna small subunit methyltransferase
CH53_2028	COG0552	protein localization to endoplasmic reticulum
CH53_2029	COG2884	Cell division ATP-binding protein ftsE
CH53_203	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH53_2030	COG2177	Part of the ABC transporter FtsEX involved in
CH53_2032	COG0456	acetyltransferase
CH53_2033	COG0683	leucine binding
CH53_2034	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH53_2035	COG4177	L-phenylalanine transmembrane transporter activity
CH53_2036	COG0411	ABC transporter
CH53_2037	COG0410	ABC transporter
CH53_204	COG3842	ATPase activity
CH53_2044	COG1653	transport
CH53_2045	COG1175	transmembrane transport
CH53_2046	COG0395	ABC-type sugar transport system, permease component
CH53_2047	COG3842	ATPase activity
CH53_2048	COG0584	glycerophosphoryl diester phosphodiesterase
CH53_2049	COG0679	Auxin Efflux Carrier
CH53_205	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH53_2050	COG0583	DNA-binding transcription factor activity
CH53_2052	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CH53_2053	COG0412	Dienelactone hydrolase
CH53_2054	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CH53_2056	COG1966	Carbon starvation protein
CH53_2057	COG0586	Pfam SNARE associated Golgi protein
CH53_2058	COG1322	Protein conserved in bacteria
CH53_2059	COG2226	methyltransferase
CH53_2060	COG3165	ubiquinone biosynthetic process from chorismate
CH53_2061	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CH53_2062	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH53_2063	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH53_2064	COG0805	protein transport
CH53_2068	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CH53_2070	COG0183	Belongs to the thiolase family
CH53_2071	COG1024	Enoyl-CoA hydratase
CH53_2071	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH53_2073	COG1739	Uncharacterized protein family UPF0029
CH53_2074	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH53_208	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH53_2081	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CH53_2081	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CH53_2082	COG1072	(Pantothenic acid kinase))
CH53_2089	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH53_209	COG0569	domain protein
CH53_209	COG2985	domain, Protein
CH53_2090	COG0250	Participates in transcription elongation, termination and antitermination
CH53_2091	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CH53_2092	COG0081	regulation of translation
CH53_2093	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CH53_2094	COG0222	ribosome binding
CH53_2095	COG0085	RNA polymerase activity
CH53_2096	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CH53_2098	COG2022	thiamine diphosphate biosynthetic process
CH53_2099	COG2104	thiamine diphosphate biosynthetic process
CH53_2100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH53_2102	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CH53_2103	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CH53_2104	COG2816	NAD+ diphosphatase activity
CH53_2105	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CH53_2106	COG1515	deoxyribonuclease V activity
CH53_2107	COG3068	Protein conserved in bacteria
CH53_211	COG0671	phosphoesterase, PA-phosphatase related
CH53_2110	COG0151	Belongs to the GarS family
CH53_2111	COG0138	bifunctional purine biosynthesis protein purh
CH53_212	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH53_2120	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CH53_2121	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH53_2123	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CH53_2124	COG0183	Belongs to the thiolase family
CH53_2125	COG2031	fatty acid transporter
CH53_2126	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CH53_2127	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CH53_2128	COG2204	response regulator
CH53_2129	COG3852	Histidine kinase
CH53_213	COG1349	DNA-binding transcription factor activity
CH53_2138	COG0527	aspartate kinase activity
CH53_214	COG0814	amino acid
CH53_2140	COG3223	Belongs to the PsiE family
CH53_2141	COG3833	ABC-type maltose transport systems, permease component
CH53_2142	COG1175	transmembrane transport
CH53_2145	COG4580	involved in the transport of maltose and maltodextrins
CH53_2147	COG3161	chorismate lyase activity
CH53_2149	COG2937	Belongs to the GPAT DAPAT family
CH53_215	COG1760	l-serine dehydratase
CH53_2150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH53_2151	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CH53_2152	COG3237	CsbD-like
CH53_2153	COG0735	belongs to the Fur family
CH53_2154	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH53_2156	COG0604	alcohol dehydrogenase
CH53_2157	COG0305	Participates in initiation and elongation during chromosome replication
CH53_2158	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH53_2159	COG1448	Aminotransferase
CH53_216	COG1686	Belongs to the peptidase S11 family
CH53_2160	COG2315	Protein conserved in bacteria
CH53_2161	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH53_2162	COG0629	single-stranded DNA binding
CH53_2163	COG3550	peptidyl-serine autophosphorylation
CH53_2166	COG2252	PERMEase
CH53_2167	COG0025	NhaP-type Na H and K H
CH53_2168	COG0583	DNA-binding transcription factor activity
CH53_2169	COG1380	Effector of murein hydrolase LrgA
CH53_2171	COG1126	abc transporter atp-binding protein
CH53_2172	COG0765	amino acid transport
CH53_2173	COG4597	amino acid ABC transporter
CH53_2174	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_2176	COG1560	Kdo2-lipid A biosynthetic process
CH53_2178	COG1129	ABC transporter
CH53_2179	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_218	COG0626	cystathionine gamma-synthase activity
CH53_2181	COG1069	ribulokinase activity
CH53_2183	COG0471	metal ion transport
CH53_2184	COG1278	Cold shock
CH53_2185	COG1278	Cold shock
CH53_2186	COG3133	Outer membrane lipoprotein
CH53_2188	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH53_2189	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH53_219	COG2011	ABC-type metal ion transport system permease component
CH53_2190	COG2264	protein methyltransferase activity
CH53_2191	COG4145	pantothenate transmembrane transporter activity
CH53_2192	COG3924	membrane
CH53_2193	COG0439	Biotin carboxylase
CH53_2194	COG0511	ligase activity, forming carbon-carbon bonds
CH53_2196	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CH53_2198	COG0604	alcohol dehydrogenase
CH53_2199	COG2200	EAL domain
CH53_2199	COG2199	diguanylate cyclase activity
CH53_22	COG0628	permease
CH53_2200	COG1077	Cell shape determining protein MreB Mrl
CH53_2201	COG1792	Involved in formation and maintenance of cell shape
CH53_2202	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH53_2204	COG1530	ribonuclease E activity
CH53_2205	COG3164	Protein of unknown function
CH53_2206	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH53_2207	COG0312	modulator of DNA gyrase
CH53_2208	COG0583	DNA-binding transcription factor activity
CH53_2210	COG1566	PFAM secretion protein HlyD family protein
CH53_2211	COG1289	transmembrane transporter activity
CH53_2212	COG1012	belongs to the aldehyde dehydrogenase family
CH53_2214	COG2732	(Barnase) inhibitor
CH53_2215	COG3028	Belongs to the UPF0307 family
CH53_2216	COG0312	modulator of DNA gyrase
CH53_2217	COG3783	Cytochrome b(562)
CH53_2218	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH53_2224	COG3964	amidohydrolase
CH53_2227	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_2227	COG3711	transcriptional antiterminator
CH53_2228	COG3093	addiction module antidote protein HigA
CH53_2231	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH53_2233	COG1263	PTS System
CH53_2233	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_2234	COG0366	Alpha amylase catalytic
CH53_2236	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CH53_2237	COG0540	Belongs to the ATCase OTCase family
CH53_2239	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH53_2240	COG2271	Major facilitator Superfamily
CH53_2241	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_2242	COG1660	Displays ATPase and GTPase activities
CH53_2243	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_2245	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH53_2246	COG1137	ATPase activity
CH53_2247	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH53_2248	COG3117	lipopolysaccharide transmembrane transporter activity
CH53_2249	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH53_225	COG0625	glutathione transferase activity
CH53_2250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH53_2250	COG0517	IMP dehydrogenase activity
CH53_2251	COG0530	calcium, potassium:sodium antiporter activity
CH53_2252	COG1127	ABC transporter
CH53_2253	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH53_2254	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH53_2255	COG2854	intermembrane phospholipid transfer
CH53_2256	COG3113	response to antibiotic
CH53_2257	COG5007	Belongs to the BolA IbaG family
CH53_2258	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CH53_2259	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH53_226	COG4771	TonB-dependent receptor
CH53_2260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH53_2261	COG3105	Protein conserved in bacteria
CH53_2262	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH53_2263	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CH53_2264	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CH53_2265	COG0625	glutathione transferase activity
CH53_2266	COG2969	positive regulation of protein catabolic process
CH53_2268	COG0493	'glutamate synthase
CH53_2269	COG0069	glutamate synthase activity
CH53_2269	COG0067	glutamate synthase
CH53_2269	COG0070	glutamate synthase
CH53_227	COG0833	amino acid
CH53_2270	COG1242	4 iron, 4 sulfur cluster binding
CH53_2271	COG5002	protein histidine kinase activity
CH53_2271	COG0784	Response regulator, receiver
CH53_2271	COG2198	Histidine kinase
CH53_2272	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH53_2273	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH53_2274	COG2823	Periplasmic or secreted lipoprotein
CH53_2275	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH53_2276	COG0792	nuclease activity
CH53_2279	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH53_228	COG0583	DNA-binding transcription factor activity
CH53_2284	COG1064	alcohol dehydrogenase
CH53_2285	COG1741	Belongs to the pirin family
CH53_2286	COG0583	DNA-binding transcription factor activity
CH53_2287	COG0435	Glutathione S-transferase
CH53_2288	COG2259	Doxx family
CH53_2290	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH53_2291	COG4575	ribosome binding
CH53_2294	COG0586	Pfam SNARE associated Golgi protein
CH53_2298	COG2271	Major facilitator Superfamily
CH53_230	COG2855	membrane
CH53_2300	COG0246	Mannitol dehydrogenase
CH53_2301	COG2721	sulfolactate sulfo-lyase activity
CH53_2303	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CH53_2304	COG0861	Integral membrane protein TerC family
CH53_2305	COG0673	inositol 2-dehydrogenase activity
CH53_2306	COG1451	nucleotide metabolic process
CH53_2307	COG3468	outer membrane autotransporter barrel domain protein
CH53_231	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CH53_2310	COG2813	Specifically methylates the guanine in position
CH53_2311	COG1902	pentaerythritol trinitrate reductase activity
CH53_2311	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH53_2313	COG2378	regulation of single-species biofilm formation
CH53_2315	COG3247	response to pH
CH53_2316	COG2814	Major facilitator Superfamily
CH53_232	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH53_232	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH53_232	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH53_2324	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH53_2325	COG0358	DNA primase activity
CH53_2328	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CH53_2329	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CH53_233	COG1105	Belongs to the carbohydrate kinase PfkB family
CH53_2330	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH53_2332	COG0617	tRNA 3'-terminal CCA addition
CH53_2333	COG4991	sh3 domain protein
CH53_2334	COG3025	triphosphatase activity
CH53_2335	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CH53_2336	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CH53_2336	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH53_2337	COG0531	amino acid
CH53_2339	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH53_2340	COG3384	dioxygenase
CH53_2341	COG0754	glutathionylspermidine amidase activity
CH53_2342	COG5463	Belongs to the UPF0441 family
CH53_2343	COG1538	Outer membrane efflux protein
CH53_2344	COG0494	nUDIX hydrolase
CH53_2345	COG3151	Protein conserved in bacteria
CH53_2346	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH53_2347	COG3150	esterase
CH53_2348	COG0187	DNA topoisomerase II activity
CH53_2350	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH53_2351	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH53_2352	COG0745	RESPONSE REGULATOR receiver
CH53_2353	COG2205	protein histidine kinase activity
CH53_2354	COG1653	transport
CH53_2355	COG0667	Aldo Keto reductase
CH53_2356	COG0583	DNA-binding transcription factor activity
CH53_2358	COG3716	PTS system mannose fructose sorbose family IID component
CH53_2359	COG3715	PTS system
CH53_236	COG3005	denitrification pathway
CH53_2360	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_2361	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH53_2362	COG0204	Acyl-transferase
CH53_2363	COG2132	Multicopper oxidase
CH53_2367	COG0656	L-ascorbic acid biosynthetic process
CH53_2368	COG1979	alcohol dehydrogenase
CH53_2369	COG2207	Transcriptional regulator
CH53_2370	COG0586	Pfam SNARE associated Golgi protein
CH53_2371	COG0626	cystathionine gamma-synthase activity
CH53_2372	COG0811	peptide transport
CH53_2373	COG0848	biopolymer transport protein
CH53_238	COG1349	DNA-binding transcription factor activity
CH53_2384	COG4964	Belongs to the GSP D family
CH53_2390	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH53_2391	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_2396	COG1120	ATPase activity
CH53_2397	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH53_2398	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH53_2399	COG4592	Periplasmic binding protein
CH53_240	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_2400	COG0840	transmembrane signaling receptor activity
CH53_2404	COG3133	Outer membrane lipoprotein
CH53_2405	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CH53_2406	COG0437	4 iron, 4 sulfur cluster binding
CH53_2407	COG5557	Pfam Polysulphide reductase, NrfD
CH53_2408	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CH53_2409	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH53_2410	COG1773	rubredoxin
CH53_2411	COG0375	protein maturation
CH53_2412	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH53_2413	COG0298	carbon dioxide binding
CH53_2414	COG0409	Hydrogenase expression formation protein
CH53_2415	COG0309	Hydrogenase expression formation protein (HypE)
CH53_2416	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CH53_2417	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CH53_2418	COG5001	Diguanylate cyclase
CH53_242	COG3716	PTS system mannose fructose sorbose family IID component
CH53_2420	COG4303	Ethanolamine ammonia lyase large subunit
CH53_2421	COG4302	ethanolamine ammonia-lyase activity
CH53_2422	COG0477	Major facilitator Superfamily
CH53_2424	COG0745	RESPONSE REGULATOR receiver
CH53_2424	COG3706	GGDEF domain
CH53_2426	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CH53_2427	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH53_2428	COG1283	sodium-dependent phosphate transmembrane transporter activity
CH53_2429	COG4607	ABC-type enterochelin transport system periplasmic component
CH53_243	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_2431	COG4605	iron ion homeostasis
CH53_2432	COG4604	ABC transporter, ATP-binding protein
CH53_244	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH53_2444	COG1289	transmembrane transporter activity
CH53_245	COG2222	sugar isomerase
CH53_2451	COG3121	Chaperone
CH53_2452	COG3121	Chaperone
CH53_2453	COG3188	usher protein
CH53_2458	COG3547	Transposase (IS116 IS110 IS902 family)
CH53_2476	COG2040	homocysteine
CH53_2477	COG0833	amino acid
CH53_2478	COG1230	cation diffusion facilitator family transporter
CH53_2485	COG3038	cytochrome b561
CH53_2486	COG0789	Transcriptional regulator
CH53_2488	COG0300	oxidoreductase activity
CH53_2491	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH53_2494	COG5001	Diguanylate cyclase
CH53_2494	COG5002	protein histidine kinase activity
CH53_2494	COG3447	MASE1 domain protein
CH53_2495	COG1105	Belongs to the carbohydrate kinase PfkB family
CH53_2498	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CH53_2499	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_2499	COG2190	(PTS) system
CH53_2499	COG1263	PTS System
CH53_250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH53_2503	COG2188	Transcriptional regulator
CH53_2504	COG3916	Acyl-homoserine-lactone synthase
CH53_2505	COG2771	luxR family
CH53_2506	COG4810	utilization protein
CH53_2507	COG4917	ethanolamine utilization protein
CH53_2508	COG4766	ethanolamine catabolic process
CH53_251	COG1312	Catalyzes the dehydration of D-mannonate
CH53_2511	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CH53_2512	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CH53_2514	COG4820	ethanolamine utilization protein (EutJ)
CH53_2518	COG4303	Ethanolamine ammonia lyase large subunit
CH53_252	COG0246	Mannitol dehydrogenase
CH53_2520	COG4816	utilization protein
CH53_2523	COG2207	Transcriptional regulator
CH53_253	COG2186	Transcriptional regulator
CH53_2533	COG2197	response regulator
CH53_2545	COG3121	Chaperone
CH53_2546	COG3188	usher protein
CH53_255	COG0523	cobalamin synthesis protein
CH53_2555	COG3501	Rhs element vgr protein
CH53_256	COG0671	phosphoesterase, PA-phosphatase related
CH53_2561	COG2197	response regulator
CH53_2562	COG2197	response regulator
CH53_2563	COG2205	protein histidine kinase activity
CH53_2563	COG0784	Response regulator, receiver
CH53_2563	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_2563	COG2198	Histidine kinase
CH53_2567	COG0288	reversible hydration of carbon dioxide
CH53_2568	COG2801	Transposase and inactivated derivatives
CH53_2568	COG2801	Transposase and inactivated derivatives
CH53_257	COG0791	NLP P60 protein
CH53_2573	COG1982	Orn Lys Arg decarboxylase major
CH53_2575	COG0741	lytic transglycosylase activity
CH53_2577	COG1194	a g-specific adenine glycosylase
CH53_2578	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CH53_2579	COG3171	Protein conserved in bacteria
CH53_258	COG2200	EAL domain
CH53_2580	COG2066	Belongs to the glutaminase family
CH53_2582	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH53_2583	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH53_2584	COG1872	DUF167
CH53_2585	COG0762	integral membrane protein
CH53_2586	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH53_2587	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH53_2588	COG2805	Type II/IV secretion system protein
CH53_259	COG4166	transmembrane transport
CH53_2590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH53_2591	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CH53_2592	COG1678	Uncharacterized ACR, COG1678
CH53_2593	COG0189	ligase activity
CH53_2594	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH53_2595	COG2356	endonuclease I
CH53_2596	COG3091	SprT-like family
CH53_2597	COG0640	Transcriptional regulator
CH53_260	COG4174	ABC transporter (Permease)
CH53_2600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CH53_2601	COG1166	arginine decarboxylase activity
CH53_2603	COG0501	Belongs to the peptidase M48B family
CH53_2604	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH53_2605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH53_2606	COG0126	phosphoglycerate kinase activity
CH53_2607	COG0191	fructose-bisphosphate aldolase activity
CH53_2609	COG1279	arginine transmembrane transporter activity
CH53_261	COG4239	(ABC) transporter, permease
CH53_2611	COG0583	DNA-binding transcription factor activity
CH53_2612	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH53_2613	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH53_2614	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH53_2615	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CH53_2616	COG3079	Belongs to the UPF0149 family
CH53_2617	COG0006	proline dipeptidase activity
CH53_2618	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH53_2619	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH53_262	COG4172	Belongs to the ABC transporter superfamily
CH53_2620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CH53_2621	COG0509	glycine decarboxylation via glycine cleavage system
CH53_2622	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH53_2622	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH53_2624	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_2626	COG1272	protein, Hemolysin III
CH53_2627	COG0354	folic acid binding
CH53_2628	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CH53_2630	COG0745	RESPONSE REGULATOR receiver
CH53_2631	COG2205	protein histidine kinase activity
CH53_2632	COG4452	Inner membrane protein CreD
CH53_2633	COG0716	FMN binding
CH53_2634	COG4974	Belongs to the 'phage' integrase family
CH53_2636	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH53_2637	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH53_2638	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CH53_2643	COG3706	GGDEF domain
CH53_2644	COG1522	sequence-specific DNA binding
CH53_2647	COG2271	Major facilitator Superfamily
CH53_2649	COG0484	heat shock protein binding
CH53_265	COG2814	Major facilitator Superfamily
CH53_2651	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_2652	COG1733	regulation of RNA biosynthetic process
CH53_2653	COG0288	reversible hydration of carbon dioxide
CH53_2657	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH53_2659	COG2165	general secretion pathway protein
CH53_266	COG1187	pseudouridine synthase activity
CH53_2660	COG2165	general secretion pathway protein
CH53_267	COG1061	Type III restriction enzyme res subunit
CH53_2672	COG0583	DNA-binding transcription factor activity
CH53_2673	COG0583	DNA-binding transcription factor activity
CH53_2674	COG0019	diaminopimelate decarboxylase activity
CH53_2676	COG1609	Transcriptional regulator
CH53_2678	COG0204	Acyl-transferase
CH53_2678	COG0318	PFAM AMP-dependent synthetase and ligase
CH53_2679	COG0477	Major facilitator Superfamily
CH53_2680	COG0667	Aldo Keto reductase
CH53_2681	COG0861	Integral membrane protein TerC family
CH53_2683	COG3066	DNA modification
CH53_2686	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CH53_2688	COG2165	general secretion pathway protein
CH53_2689	COG4795	General secretion pathway protein
CH53_269	COG3081	Nucleoid-associated protein
CH53_2692	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH53_2693	COG1025	Belongs to the peptidase M16 family
CH53_2694	COG1074	ATP-dependent DNA helicase activity
CH53_2695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH53_2696	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CH53_2696	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH53_2697	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH53_270	COG3082	Protein of unknown function (DUF1414)
CH53_2701	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH53_2702	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH53_2703	COG2166	iron-sulfur cluster assembly
CH53_2704	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH53_2706	COG0583	DNA-binding transcription factor activity
CH53_2707	COG2363	Small membrane protein
CH53_2708	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CH53_2709	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH53_2710	COG1611	Belongs to the LOG family
CH53_2711	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH53_2711	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH53_2713	COG3098	single-species biofilm formation
CH53_2714	COG0564	pseudouridine synthase activity
CH53_2717	COG2171	N-acyltransferase activity
CH53_2718	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CH53_2719	COG0024	Methionine aminopeptidase
CH53_2720	COG0052	Belongs to the universal ribosomal protein uS2 family
CH53_2721	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CH53_2722	COG0528	UMP kinase activity
CH53_2723	COG0233	cytoplasmic translational termination
CH53_2724	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CH53_2725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CH53_2726	COG0575	Belongs to the CDS family
CH53_2727	COG0750	zinc metalloprotease
CH53_2729	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH53_2731	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH53_2732	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH53_2733	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH53_2734	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CH53_2736	COG0825	malonyl-CoA metabolic process
CH53_2738	COG0346	lactoylglutathione lyase activity
CH53_2739	COG0037	tRNA processing
CH53_274	COG3338	carbonate dehydratase activity
CH53_2741	COG4568	rho-dependent transcription termination
CH53_2743	COG4681	YaeQ
CH53_2745	COG3015	lipoprotein NlpE involved in copper resistance
CH53_2746	COG0442	prolyl-tRNA aminoacylation
CH53_2747	COG1720	tRNA m6t6A37 methyltransferase activity
CH53_2749	COG1464	Belongs to the NlpA lipoprotein family
CH53_275	COG2723	6-phospho-beta-galactosidase activity
CH53_2750	COG2011	ABC-type metal ion transport system permease component
CH53_2752	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH53_2758	COG5544	Lipoprotein
CH53_2759	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH53_276	COG2190	(PTS) system
CH53_276	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_276	COG1263	PTS System
CH53_2760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH53_2760	COG1042	CoA-binding domain protein
CH53_2760	COG0045	succinate-CoA ligase (ADP-forming) activity
CH53_2762	COG3118	belongs to the thioredoxin family
CH53_2763	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH53_2764	COG2814	Major facilitator Superfamily
CH53_2765	COG1566	PFAM secretion protein HlyD family protein
CH53_2766	COG1846	Transcriptional regulator
CH53_2768	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH53_2769	COG2814	Major facilitator Superfamily
CH53_2771	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH53_2774	COG0436	Aminotransferase
CH53_2775	COG0235	Class ii aldolase
CH53_2777	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CH53_2779	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CH53_2782	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH53_2783	COG1960	acyl-CoA dehydrogenase activity
CH53_2784	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH53_2785	COG3034	peptidoglycan biosynthetic process
CH53_2786	COG0121	glutamine amidotransferase
CH53_2787	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH53_2788	COG1805	sodium ion transport
CH53_2789	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH53_2790	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH53_2791	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH53_2792	COG2871	sodium ion transport
CH53_2793	COG1477	protein flavinylation
CH53_2794	COG2991	Protein conserved in bacteria
CH53_2797	COG1181	Belongs to the D-alanine--D-alanine ligase family
CH53_2798	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CH53_2799	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH53_2803	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CH53_2804	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CH53_2805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH53_2806	COG2313	pseudouridylate synthase activity
CH53_2807	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH53_2809	COG3459	Glycosyltransferase 36 associated
CH53_281	COG3299	homolog of phage Mu protein gp47
CH53_2812	COG2226	methyltransferase
CH53_2815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH53_2816	COG3123	guanosine phosphorylase activity
CH53_2817	COG2974	May be involved in recombination
CH53_2818	COG1940	carbohydrate kinase activity
CH53_2819	COG0419	ATPase involved in DNA repair
CH53_2820	COG0420	3'-5' exonuclease activity
CH53_2821	COG0745	RESPONSE REGULATOR receiver
CH53_2822	COG5002	protein histidine kinase activity
CH53_2824	COG1114	Component of the transport system for branched-chain amino acids
CH53_2826	COG0366	Alpha amylase catalytic
CH53_2829	COG0450	alkyl hydroperoxide reductase
CH53_2830	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH53_2831	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CH53_2833	COG1862	Preprotein translocase
CH53_2834	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH53_2835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH53_2837	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CH53_2838	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH53_2838	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH53_2839	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CH53_2841	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH53_2842	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH53_2843	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CH53_2844	COG0142	geranyltranstransferase activity
CH53_2846	COG0301	tRNA thio-modification
CH53_2846	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH53_2847	COG0693	protein deglycase activity
CH53_2848	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH53_2849	COG1666	GTP binding
CH53_2850	COG2814	Major facilitator Superfamily
CH53_2851	COG0109	protoheme IX farnesyltransferase activity
CH53_2852	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH53_2853	COG1845	cytochrome c oxidase, subunit III
CH53_2854	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH53_2855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH53_2857	COG2223	nitrite transmembrane transporter activity
CH53_2858	COG3056	Lipoprotein
CH53_2859	COG0271	Belongs to the BolA IbaG family
CH53_2861	COG0740	serine-type endopeptidase activity
CH53_2862	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH53_2863	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH53_2864	COG0776	regulation of translation
CH53_2865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH53_2866	COG1555	photosystem II stabilization
CH53_2867	COG0824	Thioesterase
CH53_2868	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CH53_2869	COG4533	DNA binding
CH53_2870	COG0561	phosphatase activity
CH53_2872	COG1522	sequence-specific DNA binding
CH53_2873	COG1132	(ABC) transporter
CH53_2874	COG1132	(ABC) transporter
CH53_2875	COG0347	Belongs to the P(II) protein family
CH53_2876	COG0004	ammonium transporteR
CH53_2877	COG1946	Acyl-CoA thioesterase
CH53_2878	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH53_2879	COG3695	enzyme binding
CH53_2884	COG1121	(ABC) transporter
CH53_2885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH53_2886	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH53_2887	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH53_2888	COG0254	rRNA binding
CH53_2889	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH53_289	COG4386	tail sheath protein
CH53_2890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_2891	COG1309	transcriptional regulator
CH53_2892	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH53_2894	COG1196	nuclear chromosome segregation
CH53_2894	COG3264	Mechanosensitive ion channel
CH53_2896	COG2832	Protein of unknown function (DUF454)
CH53_2897	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH53_2899	COG0346	lactoylglutathione lyase activity
CH53_2900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CH53_2901	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CH53_2902	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CH53_2903	COG0326	Molecular chaperone. Has ATPase activity
CH53_2904	COG0563	adenylate kinase activity
CH53_2905	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CH53_2906	COG2244	polysaccharide biosynthetic process
CH53_2907	COG1216	Glycosyl transferase, family 2
CH53_2907	COG1442	glycosyl transferase family 8
CH53_2908	COG1215	transferase activity, transferring glycosyl groups
CH53_2909	COG0438	transferase activity, transferring glycosyl groups
CH53_2910	COG0438	transferase activity, transferring glycosyl groups
CH53_2911	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH53_2915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH53_2916	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH53_2916	COG4651	solute:proton antiporter activity
CH53_2917	COG2223	nitrite transmembrane transporter activity
CH53_2918	COG0737	Belongs to the 5'-nucleotidase family
CH53_2919	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH53_2920	COG3735	TraB family
CH53_2921	COG2217	Heavy metal translocating P-type atpase
CH53_2922	COG0789	Transcriptional regulator
CH53_2923	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH53_2924	COG0330	HflC and HflK could
CH53_2925	COG3118	belongs to the thioredoxin family
CH53_2926	COG0300	oxidoreductase activity
CH53_2927	COG2755	lipolytic protein G-D-S-L family
CH53_2928	COG4181	ATPase activity
CH53_2929	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH53_2930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH53_2931	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH53_2932	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH53_2933	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH53_2934	COG0215	cysteine-tRNA ligase activity
CH53_2935	COG2501	S4 domain
CH53_2936	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CH53_2938	COG0582	viral genome integration into host DNA
CH53_294	COG3772	lysozyme
CH53_2943	COG2207	Transcriptional regulator
CH53_2947	COG0583	DNA-binding transcription factor activity
CH53_2948	COG0402	S-adenosylhomocysteine deaminase activity
CH53_2960	COG1309	transcriptional regulator
CH53_2961	COG2814	Major facilitator Superfamily
CH53_2962	COG1309	transcriptional regulator
CH53_2963	COG2826	transposase and inactivated derivatives, IS30 family
CH53_2968	COG0477	Major facilitator Superfamily
CH53_2969	COG0640	Transcriptional regulator
CH53_2970	COG0583	DNA-binding transcription factor activity
CH53_2971	COG0596	Alpha beta hydrolase
CH53_2982	COG0582	viral genome integration into host DNA
CH53_2983	COG0582	viral genome integration into host DNA
CH53_2986	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH53_2987	COG1328	CTP reductase activity
CH53_2989	COG2211	Major facilitator Superfamily
CH53_2990	COG1486	melibiose metabolic process
CH53_2991	COG2169	Transcriptional regulator
CH53_2992	COG3240	lipase activity
CH53_3	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH53_30	COG1560	Kdo2-lipid A biosynthetic process
CH53_3008	COG3122	Protein conserved in bacteria
CH53_3012	COG1401	restriction endodeoxyribonuclease activity
CH53_3015	COG0583	DNA-binding transcription factor activity
CH53_3018	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CH53_3019	COG0583	DNA-binding transcription factor activity
CH53_3020	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_3022	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH53_3029	COG1902	pentaerythritol trinitrate reductase activity
CH53_303	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH53_3031	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_3033	COG2610	gluconate transmembrane transporter activity
CH53_3036	COG1940	carbohydrate kinase activity
CH53_3037	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH53_3038	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_3039	COG1129	ABC transporter
CH53_3040	COG1879	ABC-type sugar transport system periplasmic component
CH53_3041	COG1737	Transcriptional regulator
CH53_3042	COG0698	ribose 5-phosphate isomerase
CH53_3043	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH53_3045	COG2850	peptidyl-arginine hydroxylation
CH53_3047	COG5265	(ABC) transporter
CH53_3050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH53_3052	COG2197	response regulator
CH53_3053	COG1278	Cold shock
CH53_3054	COG1278	Cold shock
CH53_3055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH53_3056	COG3706	GGDEF domain
CH53_3057	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH53_3058	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CH53_3059	COG0321	lipoyl(octanoyl) transferase activity
CH53_306	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH53_306	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH53_3060	COG2921	Belongs to the UPF0250 family
CH53_3061	COG1686	Belongs to the peptidase S11 family
CH53_3062	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH53_3063	COG0772	Belongs to the SEDS family
CH53_3064	COG0768	penicillin binding
CH53_3066	COG0799	negative regulation of ribosome biogenesis
CH53_3067	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CH53_3068	COG1466	dna polymerase III delta subunit
CH53_3069	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CH53_307	COG0583	DNA-binding transcription factor activity
CH53_3070	COG0495	leucyl-tRNA aminoacylation
CH53_3071	COG2888	peptidyl-tyrosine sulfation
CH53_3073	COG1126	abc transporter atp-binding protein
CH53_3074	COG0765	amino acid transport
CH53_3075	COG0765	amino acid transport
CH53_3078	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH53_3079	COG4535	Mg2 and Co2 transporter CorC
CH53_308	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH53_308	COG1648	precorrin-2 dehydrogenase activity
CH53_3080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CH53_3081	COG1702	phosphate starvation-inducible protein PhoH
CH53_3082	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CH53_3083	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH53_3092	COG0367	asparagine synthase
CH53_3094	COG0647	UMP catabolic process
CH53_3095	COG1940	carbohydrate kinase activity
CH53_3095	COG1846	Transcriptional regulator
CH53_3096	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH53_3097	COG0363	glucosamine-6-phosphate deaminase activity
CH53_3098	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_3098	COG1263	PTS System
CH53_3098	COG2190	(PTS) system
CH53_3099	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH53_31	COG2259	Doxx family
CH53_310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH53_3103	COG0735	belongs to the Fur family
CH53_3105	COG0840	transmembrane signaling receptor activity
CH53_3108	COG0596	Alpha beta hydrolase
CH53_3109	COG2831	hemolysin activation secretion protein
CH53_3110	COG3210	domain, Protein
CH53_3115	COG3316	Transposase and inactivated derivatives
CH53_3118	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH53_3119	COG0033	Phosphoglucomutase
CH53_312	COG4865	methylaspartate mutase activity
CH53_3121	COG0745	RESPONSE REGULATOR receiver
CH53_3122	COG2205	protein histidine kinase activity
CH53_3123	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CH53_3124	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CH53_3127	COG3272	Protein of unknown function (DUF1722)
CH53_3129	COG5212	phosphodiesterase
CH53_313	COG3799	methylaspartate ammonia-lyase activity
CH53_3130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH53_3131	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH53_3132	COG1984	allophanate hydrolase subunit 2
CH53_3133	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CH53_3138	COG2009	succinate dehydrogenase
CH53_3139	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH53_3140	COG1053	succinate dehydrogenase
CH53_3142	COG0567	Dehydrogenase, E1 component
CH53_3143	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH53_3144	COG0045	succinate-CoA ligase (ADP-forming) activity
CH53_3145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH53_3146	COG0737	Belongs to the 5'-nucleotidase family
CH53_3147	COG1271	oxidase subunit
CH53_3148	COG1294	oxidase, subunit
CH53_3149	COG4890	Cyd operon protein YbgT
CH53_3150	COG3790	cyd operon protein YbgE
CH53_3151	COG0824	Thioesterase
CH53_3152	COG0811	peptide transport
CH53_3153	COG0848	biopolymer transport protein
CH53_3154	COG3064	Membrane
CH53_3154	COG3064	Membrane
CH53_3155	COG0823	Involved in the tonB-independent uptake of proteins
CH53_3156	COG2885	chlorophyll binding
CH53_3157	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH53_316	COG1301	dicarboxylic acid transport
CH53_3162	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CH53_3164	COG1230	cation diffusion facilitator family transporter
CH53_3165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_3165	COG2205	protein histidine kinase activity
CH53_3166	COG2197	response regulator
CH53_3167	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH53_3168	COG0588	phosphoglycerate mutase activity
CH53_3170	COG2017	converts alpha-aldose to the beta-anomer
CH53_3171	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CH53_3173	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH53_3175	COG1119	ATPase activity
CH53_3176	COG2005	Transcriptional regulator
CH53_3176	COG3585	molybdate ion transport
CH53_3178	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH53_3179	COG4149	molybdate abc transporter
CH53_3181	COG0561	phosphatase activity
CH53_3182	COG2706	6-phosphogluconolactonase activity
CH53_3184	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CH53_3186	COG2226	methyltransferase
CH53_3187	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH53_319	COG3188	usher protein
CH53_3190	COG0556	nucleotide-excision repair
CH53_3191	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH53_3192	COG4628	conserved protein (DUF2132)
CH53_3193	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH53_3194	COG0315	cyclic pyranopterin monophosphate synthase activity
CH53_3195	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH53_3196	COG0314	molybdopterin synthase activity
CH53_3197	COG0670	Belongs to the BI1 family
CH53_3198	COG0842	Transport permease protein
CH53_3199	COG0842	Transport permease protein
CH53_32	COG2814	Major facilitator Superfamily
CH53_3200	COG1131	(ABC) transporter
CH53_3201	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_3202	COG1309	transcriptional regulator
CH53_3203	COG0513	Belongs to the DEAD box helicase family
CH53_3204	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH53_3205	COG2239	Acts as a magnesium transporter
CH53_3207	COG1686	Belongs to the peptidase S11 family
CH53_3208	COG0277	FAD linked oxidase domain protein
CH53_3210	COG1403	HNH endonuclease
CH53_3212	COG2261	transglycosylase associated protein
CH53_3214	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CH53_3217	COG4807	Protein conserved in bacteria
CH53_3219	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH53_3221	COG0411	ABC transporter
CH53_3223	COG2897	thiosulfate sulfurtransferase activity
CH53_3224	COG0673	inositol 2-dehydrogenase activity
CH53_3226	COG1732	Glycine betaine
CH53_3227	COG1174	glycine betaine transport
CH53_3228	COG1125	glycine betaine transport
CH53_3229	COG1174	glycine betaine transport
CH53_3231	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_3233	COG0583	DNA-binding transcription factor activity
CH53_3234	COG0697	spore germination
CH53_3238	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH53_3239	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH53_3240	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CH53_3241	COG1126	abc transporter atp-binding protein
CH53_3242	COG0765	amino acid transport
CH53_3243	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_3244	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH53_3246	COG4106	trans-aconitate 2-methyltransferase activity
CH53_3248	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH53_3252	COG0488	(ABC) transporter
CH53_3253	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH53_3254	COG0303	'Molybdopterin
CH53_3257	COG0477	Major facilitator Superfamily
CH53_3259	COG1136	(ABC) transporter
CH53_3265	COG0583	DNA-binding transcription factor activity
CH53_3266	COG0477	Major facilitator Superfamily
CH53_3267	COG0302	gtp cyclohydrolase
CH53_3268	COG2311	Membrane
CH53_3269	COG1609	Transcriptional regulator
CH53_3273	COG2116	formate transmembrane transporter activity
CH53_3274	COG3604	Transcriptional regulator
CH53_3275	COG3383	formate dehydrogenase (NAD+) activity
CH53_3276	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_3277	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH53_3279	COG3260	NADH ubiquinone oxidoreductase 20
CH53_3280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH53_3281	COG3261	NADH dehydrogenase
CH53_3281	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CH53_3282	COG0651	ATP synthesis coupled electron transport
CH53_3283	COG4237	Hydrogenase 4 membrane
CH53_3284	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH53_3285	COG0650	Formate hydrogenlyase subunit 4
CH53_3286	COG0651	ATP synthesis coupled electron transport
CH53_3287	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_3288	COG0375	protein maturation
CH53_3289	COG0298	carbon dioxide binding
CH53_3291	COG2949	membrane
CH53_3292	COG0281	malic enzyme
CH53_3294	COG1346	cytolysis
CH53_3295	COG1380	Effector of murein hydrolase LrgA
CH53_3296	COG2814	Major facilitator Superfamily
CH53_33	COG3104	oligopeptide transport
CH53_330	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CH53_3300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH53_3300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH53_3301	COG0489	protein tyrosine kinase activity
CH53_3302	COG0572	uridine kinase
CH53_3304	COG2982	Protein involved in outer membrane biogenesis
CH53_3305	COG3069	C4-dicarboxylate transmembrane transporter activity
CH53_3306	COG1253	flavin adenine dinucleotide binding
CH53_3319	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH53_332	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH53_332	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_332	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_3320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH53_3323	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH53_3324	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH53_3325	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CH53_3326	COG0140	phosphoribosyl-ATP diphosphatase activity
CH53_3326	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH53_3327	COG0107	imidazoleglycerol-phosphate synthase activity
CH53_3329	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CH53_3330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH53_3330	COG0131	Imidazoleglycerol-phosphate dehydratase
CH53_3331	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH53_3333	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CH53_3334	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH53_3335	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_3336	COG1129	ABC transporter
CH53_3337	COG0371	Dehydrogenase
CH53_3339	COG0531	amino acid
CH53_334	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH53_3340	COG2925	Exonuclease
CH53_3344	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_3346	COG1879	ABC-type sugar transport system periplasmic component
CH53_3348	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH53_335	COG2223	nitrite transmembrane transporter activity
CH53_3350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH53_3352	COG4810	utilization protein
CH53_3354	COG4656	Part of a membrane complex involved in electron transport
CH53_3357	COG2096	Adenosyltransferase
CH53_336	COG2198	Histidine kinase
CH53_336	COG0642	Histidine kinase
CH53_3362	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CH53_3369	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CH53_3373	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CH53_3375	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CH53_3376	COG2241	protein methyltransferase activity
CH53_3378	COG2875	Belongs to the precorrin methyltransferase family
CH53_338	COG0784	Response regulator, receiver
CH53_338	COG2205	protein histidine kinase activity
CH53_3388	COG1492	cobalamin metabolic process
CH53_3392	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CH53_3393	COG0583	DNA-binding transcription factor activity
CH53_3395	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CH53_3396	COG2211	Major facilitator Superfamily
CH53_3397	COG0137	argininosuccinate synthase activity
CH53_3398	COG0534	Mate efflux family protein
CH53_3399	COG0835	chemotaxis
CH53_3399	COG0784	Response regulator, receiver
CH53_340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH53_3403	COG0561	phosphatase activity
CH53_3404	COG1349	DNA-binding transcription factor activity
CH53_3406	COG0583	DNA-binding transcription factor activity
CH53_341	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH53_3411	COG3047	cAMP biosynthetic process
CH53_3411	COG2885	chlorophyll binding
CH53_343	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH53_3430	COG3121	Chaperone
CH53_3435	COG2205	protein histidine kinase activity
CH53_3435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_3438	COG3842	ATPase activity
CH53_344	COG4574	serine-type endopeptidase inhibitor activity
CH53_3440	COG1840	ABC-type Fe3 transport system, periplasmic component
CH53_3441	COG2271	Major facilitator Superfamily
CH53_3444	COG4565	transcriptional regulatory protein
CH53_3445	COG3290	protein histidine kinase activity
CH53_3446	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CH53_3447	COG3052	prosthetic group binding
CH53_3448	COG2301	Belongs to the HpcH HpaI aldolase family
CH53_3449	COG3051	citrate lyase alpha subunit
CH53_3452	COG0471	metal ion transport
CH53_3455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH53_3458	COG2814	Major facilitator Superfamily
CH53_3460	COG2211	Major facilitator Superfamily
CH53_3463	COG2204	response regulator
CH53_350	COG0814	amino acid
CH53_3501	COG0582	viral genome integration into host DNA
CH53_3504	COG0582	viral genome integration into host DNA
CH53_3507	COG3228	Belongs to the MtfA family
CH53_3511	COG3121	Chaperone
CH53_3514	COG3121	Chaperone
CH53_3516	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH53_3522	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_3522	COG0604	alcohol dehydrogenase
CH53_3522	COG3321	synthase
CH53_3523	COG3250	beta-galactosidase activity
CH53_3524	COG1609	Transcriptional regulator
CH53_3525	COG1278	Cold shock
CH53_3527	COG0840	transmembrane signaling receptor activity
CH53_3528	COG1285	pathogenesis
CH53_3530	COG2130	NADP-dependent
CH53_3531	COG0589	response to stress
CH53_3536	COG2198	Histidine kinase
CH53_3536	COG0643	Histidine kinase
CH53_3537	COG0835	chemotaxis
CH53_3538	COG0840	transmembrane signaling receptor activity
CH53_3539	COG0840	transmembrane signaling receptor activity
CH53_354	COG1441	menaquinone biosynthetic process
CH53_3540	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH53_3542	COG0745	RESPONSE REGULATOR receiver
CH53_3543	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH53_3544	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH53_3545	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH53_3548	COG3418	PFAM FlgN family protein
CH53_3549	COG2747	anti-sigma28 factor FlgM
CH53_355	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH53_3551	COG1815	bacterial-type flagellum-dependent cell motility
CH53_3552	COG1558	bacterial-type flagellum-dependent cell motility
CH53_3553	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH53_3554	COG1749	Flagellar hook protein flgE
CH53_3556	COG4786	Flagellar basal body rod
CH53_3560	COG1256	bacterial-type flagellum assembly
CH53_3561	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH53_357	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CH53_3570	COG2882	bacterial-type flagellum organization
CH53_3572	COG1317	bacterial-type flagellum organization
CH53_3573	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH53_3575	COG1677	Flagellar hook-basal body complex protein FliE
CH53_3576	COG0582	viral genome integration into host DNA
CH53_358	COG1169	isochorismate synthase
CH53_3584	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CH53_3585	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH53_359	COG4575	ribosome binding
CH53_3591	COG1191	sigma factor activity
CH53_3593	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH53_3598	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH53_3598	COG0506	proline dehydrogenase activity
CH53_3598	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH53_3599	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH53_36	COG5645	(Lipo)protein
CH53_360	COG0129	dihydroxy-acid dehydratase activity
CH53_3605	COG1881	PFAM PEBP family protein
CH53_3607	COG1113	amino acid transport
CH53_3609	COG0582	viral genome integration into host DNA
CH53_361	COG4702	Belongs to the UPF0303 family
CH53_3610	COG2199	diguanylate cyclase activity
CH53_3610	COG2203	Gaf domain
CH53_3615	COG0366	Alpha amylase catalytic
CH53_3616	COG0840	transmembrane signaling receptor activity
CH53_3618	COG3136	membrane protein required for alginate biosynthesis
CH53_3620	COG2197	response regulator
CH53_3621	COG0322	excinuclease ABC activity
CH53_3622	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH53_363	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH53_3631	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CH53_3635	COG1802	Transcriptional regulator
CH53_3635	COG4626	Terminase
CH53_364	COG1609	Transcriptional regulator
CH53_3640	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CH53_365	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_3654	COG1733	regulation of RNA biosynthetic process
CH53_3659	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CH53_366	COG3265	gluconokinase activity
CH53_367	COG2731	YhcH YjgK YiaL family protein
CH53_3670	COG3121	Chaperone
CH53_3671	COG3188	usher protein
CH53_3674	COG2197	response regulator
CH53_3677	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH53_3678	COG0561	phosphatase activity
CH53_3679	COG2223	nitrite transmembrane transporter activity
CH53_3681	COG2197	response regulator
CH53_3683	COG2223	nitrite transmembrane transporter activity
CH53_3684	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CH53_3685	COG1140	nitrate reductase beta subunit
CH53_3686	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CH53_3687	COG2181	nitrate reductase activity
CH53_3689	COG3493	citrate carrier protein
CH53_3690	COG4565	transcriptional regulatory protein
CH53_3691	COG3290	protein histidine kinase activity
CH53_3692	COG1349	DNA-binding transcription factor activity
CH53_3693	COG2084	Dehydrogenase
CH53_3694	COG3395	kinase activity
CH53_3695	COG0235	Class ii aldolase
CH53_3696	COG3622	Belongs to the hyi family
CH53_3698	COG1609	Transcriptional regulator
CH53_3699	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH53_37	COG2943	transferase activity, transferring hexosyl groups
CH53_370	COG1007	ATP synthesis coupled electron transport
CH53_3700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH53_3701	COG2723	6-phospho-beta-galactosidase activity
CH53_3702	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH53_3704	COG0672	)-iron permease
CH53_3707	COG1136	(ABC) transporter
CH53_3707	COG0577	efflux transmembrane transporter activity
CH53_3709	COG1136	(ABC) transporter
CH53_3709	COG0577	efflux transmembrane transporter activity
CH53_371	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH53_3714	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH53_3715	COG0006	proline dipeptidase activity
CH53_3716	COG0457	Tetratricopeptide repeat
CH53_3717	COG1649	PFAM Uncharacterised BCR, COG1649
CH53_3717	COG0726	polysaccharide deacetylase
CH53_3718	COG1215	transferase activity, transferring glycosyl groups
CH53_3719	COG3658	cytochrome
CH53_372	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH53_3722	COG1702	phosphate starvation-inducible protein PhoH
CH53_3723	COG0387	Pfam Sodium calcium exchanger
CH53_3725	COG2814	Major facilitator Superfamily
CH53_3726	COG0583	DNA-binding transcription factor activity
CH53_3727	COG3850	Histidine kinase
CH53_3729	COG1294	oxidase, subunit
CH53_373	COG0713	ATP synthesis coupled electron transport
CH53_3730	COG1271	oxidase subunit
CH53_3731	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH53_3733	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CH53_3734	COG3138	arginine N-succinyltransferase
CH53_3736	COG3724	N-succinylarginine dihydrolase activity
CH53_374	COG0839	Belongs to the complex I subunit 6 family
CH53_3740	COG1228	amidohydrolase
CH53_3742	COG0402	S-adenosylhomocysteine deaminase activity
CH53_3745	COG1129	ABC transporter
CH53_3746	COG4211	Belongs to the binding-protein-dependent transport system permease family
CH53_3749	COG2814	Major facilitator Superfamily
CH53_375	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH53_3751	COG1309	transcriptional regulator
CH53_3752	COG3443	Belongs to the bacterial solute-binding protein 9 family
CH53_3754	COG4942	peptidase
CH53_3756	COG0012	GTP binding
CH53_3758	COG0193	aminoacyl-tRNA hydrolase activity
CH53_376	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CH53_3760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH53_3762	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CH53_3763	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CH53_3764	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CH53_3765	COG2890	protein-(glutamine-N5) methyltransferase activity
CH53_3766	COG3094	Invasion gene expression up-regulator, SirB
CH53_3767	COG2912	Transglutaminase-like superfamily
CH53_3769	COG0659	secondary active sulfate transmembrane transporter activity
CH53_377	COG1034	ATP synthesis coupled electron transport
CH53_3770	COG3706	GGDEF domain
CH53_3774	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH53_3776	COG3381	protein complex oligomerization
CH53_3778	COG0477	Major facilitator Superfamily
CH53_3784	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH53_3786	COG0673	inositol 2-dehydrogenase activity
CH53_3789	COG3102	Protein conserved in bacteria
CH53_379	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CH53_3790	COG3142	Participates in the control of copper homeostasis
CH53_3793	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH53_3794	COG1801	Protein of unknown function DUF72
CH53_3795	COG1335	isochorismatase
CH53_3796	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CH53_3798	COG0494	nUDIX hydrolase
CH53_3799	COG0217	transcriptional regulatory protein
CH53_38	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CH53_380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH53_380	COG0649	NAD binding
CH53_3801	COG0632	four-way junction helicase activity
CH53_3802	COG2255	four-way junction helicase activity
CH53_3803	COG3104	oligopeptide transport
CH53_3804	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH53_3805	COG1121	(ABC) transporter
CH53_3806	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH53_3807	COG0739	heme binding
CH53_3808	COG1560	Kdo2-lipid A biosynthetic process
CH53_3809	COG0469	pyruvate kinase activity
CH53_381	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH53_3810	COG1737	Transcriptional regulator
CH53_3811	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH53_3812	COG0800	Aldolase
CH53_3813	COG2076	Multidrug Resistance protein
CH53_3814	COG2076	Multidrug Resistance protein
CH53_3815	COG0251	oxidation-reduction process
CH53_3816	COG1199	ATP-dependent helicase activity
CH53_3818	COG3065	identical protein binding
CH53_3819	COG0318	PFAM AMP-dependent synthetase and ligase
CH53_3820	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH53_3821	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH53_3822	COG2894	cell division
CH53_3823	COG0850	regulation of cytokinetic process
CH53_3825	COG3100	YcgL domain-containing protein
CH53_3826	COG2951	lytic endotransglycosylase activity
CH53_3827	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH53_3828	COG2983	Belongs to the UPF0260 family
CH53_383	COG0583	DNA-binding transcription factor activity
CH53_3830	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH53_3834	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CH53_3835	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH53_3836	COG2186	Transcriptional regulator
CH53_3837	COG2719	SpoVR family
CH53_3838	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH53_3839	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH53_384	COG0436	Aminotransferase
CH53_3840	COG2814	Major facilitator Superfamily
CH53_3841	COG2199	diguanylate cyclase activity
CH53_3841	COG2202	Pas domain
CH53_3841	COG2200	EAL domain
CH53_3843	COG2718	Belongs to the UPF0229 family
CH53_3844	COG2766	serine protein kinase
CH53_3845	COG3713	MltA-interacting MipA family protein
CH53_3849	COG3139	Protein of unknown function (DUF1315)
CH53_3850	COG1335	isochorismatase
CH53_3851	COG0252	asparaginase activity
CH53_3852	COG0616	signal peptide processing
CH53_3853	COG0778	Nitroreductase
CH53_3855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH53_3857	COG0494	nUDIX hydrolase
CH53_3858	COG0708	Exodeoxyribonuclease III
CH53_3859	COG0583	DNA-binding transcription factor activity
CH53_386	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CH53_3864	COG0788	formyltetrahydrofolate deformylase activity
CH53_3865	COG3012	SEC-C Motif Domain Protein
CH53_3866	COG1752	Esterase of the alpha-beta hydrolase superfamily
CH53_3867	COG0745	RESPONSE REGULATOR receiver
CH53_3869	COG2916	Histone family protein nucleoid-structuring protein H-NS
CH53_387	COG0490	domain, Protein
CH53_387	COG0471	metal ion transport
CH53_3870	COG1435	thymidine kinase activity
CH53_3871	COG1454	alcohol dehydrogenase
CH53_3871	COG1012	belongs to the aldehyde dehydrogenase family
CH53_3873	COG2095	MarC family integral membrane protein
CH53_3874	COG4166	transmembrane transport
CH53_3877	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH53_3878	COG0444	Belongs to the ABC transporter superfamily
CH53_388	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH53_3880	COG3099	Belongs to the UPF0263 family
CH53_3881	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH53_3885	COG2350	Protein conserved in bacteria
CH53_3886	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH53_3887	COG1607	acyl-coa hydrolase
CH53_3888	COG2917	probably involved in intracellular septation
CH53_3892	COG3047	cAMP biosynthetic process
CH53_3894	COG0159	tryptophan synthase activity
CH53_3895	COG0133	tryptophan synthase activity
CH53_3896	COG0134	indole-3-glycerol-phosphate synthase activity
CH53_3896	COG0135	phosphoribosylanthranilate isomerase activity
CH53_3898	COG0512	Glutamine amidotransferase of anthranilate synthase
CH53_390	COG3092	negative regulation of chromosome organization
CH53_3900	COG0613	PHP domain protein
CH53_3901	COG0009	L-threonylcarbamoyladenylate synthase
CH53_3903	COG1187	pseudouridine synthase activity
CH53_3905	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_3906	COG0616	signal peptide processing
CH53_3908	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH53_3909	COG0583	DNA-binding transcription factor activity
CH53_3911	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CH53_3912	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH53_3913	COG0671	phosphoesterase, PA-phosphatase related
CH53_3914	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH53_3915	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH53_3919	COG0023	Translation Initiation Factor
CH53_392	COG0857	belongs to the CobB CobQ family
CH53_392	COG0280	phosphate acetyltransferase
CH53_3921	COG0235	Class ii aldolase
CH53_3923	COG1349	DNA-binding transcription factor activity
CH53_3924	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH53_3925	COG2879	small protein
CH53_3926	COG1966	Carbon starvation protein
CH53_3927	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CH53_3928	COG0243	molybdopterin cofactor binding
CH53_3929	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH53_393	COG1609	Transcriptional regulator
CH53_3931	COG4659	FMN binding
CH53_3932	COG4658	electron transport chain
CH53_3933	COG3708	Transcriptional regulator
CH53_3933	COG2207	Transcriptional regulator
CH53_3934	COG4656	Part of a membrane complex involved in electron transport
CH53_3936	COG4657	Part of a membrane complex involved in electron transport
CH53_3938	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CH53_394	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_3940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_3941	COG2274	protein secretion by the type I secretion system
CH53_3942	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH53_3945	COG1879	ABC-type sugar transport system periplasmic component
CH53_3947	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_3949	COG0673	inositol 2-dehydrogenase activity
CH53_3950	COG0385	Bile acid
CH53_3951	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CH53_3952	COG1263	PTS System
CH53_3952	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_3952	COG2190	(PTS) system
CH53_3953	COG4948	Mandelate Racemase Muconate Lactonizing
CH53_3955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH53_3956	COG1263	PTS System
CH53_3956	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_3957	COG1609	Transcriptional regulator
CH53_3959	COG5339	Protein conserved in bacteria
CH53_396	COG3037	sugar-specific permease SgaT UlaA
CH53_3961	COG0114	fumarate hydratase activity
CH53_3965	COG2814	Major facilitator Superfamily
CH53_3966	COG0583	DNA-binding transcription factor activity
CH53_3967	COG1940	carbohydrate kinase activity
CH53_3968	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH53_397	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH53_3972	COG1742	UPF0060 membrane protein
CH53_3974	COG4221	oxidoreductase activity
CH53_3975	COG0110	maltose O-acetyltransferase activity
CH53_398	COG0622	Phosphoesterase
CH53_3981	COG1393	Belongs to the ArsC family
CH53_3982	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH53_3987	COG0625	glutathione transferase activity
CH53_3988	COG3604	Transcriptional regulator
CH53_3989	COG1773	rubredoxin
CH53_3989	COG0426	domain, Protein
CH53_3990	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH53_3992	COG1522	sequence-specific DNA binding
CH53_3994	COG4215	(ABC) transporter
CH53_3997	COG1477	protein flavinylation
CH53_3999	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH53_4	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH53_400	COG1090	epimerase
CH53_4001	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH53_4006	COG0028	Belongs to the TPP enzyme family
CH53_4007	COG0440	acetolactate synthase activity
CH53_4008	COG0251	oxidation-reduction process
CH53_4009	COG1011	Hydrolase
CH53_401	COG4598	ABC transporter
CH53_4014	COG0738	Major facilitator superfamily
CH53_4015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH53_4017	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_4019	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CH53_402	COG4160	amino acid transport
CH53_4022	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH53_4023	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH53_4024	COG0589	response to stress
CH53_4025	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH53_4026	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH53_4028	COG0531	amino acid
CH53_403	COG4215	(ABC) transporter
CH53_4030	COG0745	RESPONSE REGULATOR receiver
CH53_4031	COG2205	protein histidine kinase activity
CH53_4032	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH53_4034	COG3591	Belongs to the peptidase S1B family
CH53_4037	COG1643	Atp-dependent helicase
CH53_4038	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CH53_4039	COG3784	Protein of unknown function (DUF1318)
CH53_404	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH53_4041	COG2911	Protein conserved in bacteria
CH53_4042	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH53_4043	COG3042	response to heat
CH53_4044	COG1285	pathogenesis
CH53_4046	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH53_4046	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH53_4046	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH53_4046	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH53_4047	COG0037	tRNA processing
CH53_4048	COG0598	Magnesium transport protein CorA
CH53_4049	COG4166	transmembrane transport
CH53_405	COG0163	prenyltransferase activity
CH53_4050	COG4948	Mandelate Racemase Muconate Lactonizing
CH53_4051	COG2866	Carboxypeptidase
CH53_4052	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH53_4056	COG3768	UPF0283 membrane protein
CH53_4057	COG3106	COG3106 Predicted ATPase
CH53_4059	COG1983	PspC domain protein
CH53_406	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH53_4061	COG1842	Phage shock protein A
CH53_4062	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH53_4066	COG4166	transmembrane transport
CH53_4067	COG4168	peptide transport system, permease
CH53_4068	COG4171	peptide transport system, permease
CH53_407	COG1286	toxin biosynthetic process
CH53_4070	COG4172	Belongs to the ABC transporter superfamily
CH53_4071	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH53_4071	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH53_4072	COG0583	DNA-binding transcription factor activity
CH53_4073	COG3104	oligopeptide transport
CH53_4077	COG0625	glutathione transferase activity
CH53_4079	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CH53_408	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH53_4081	COG3895	Periplasmic Protein
CH53_4082	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH53_4083	COG3133	Outer membrane lipoprotein
CH53_4084	COG1846	Transcriptional regulator
CH53_4086	COG1566	PFAM secretion protein HlyD family protein
CH53_4087	COG1289	transmembrane transporter activity
CH53_4088	COG4989	oxidoreductase activity
CH53_4089	COG3313	Fe-S protein
CH53_409	COG0285	dihydrofolate synthase activity
CH53_4090	COG2194	sulfuric ester hydrolase activity
CH53_4091	COG1309	transcriptional regulator
CH53_4092	COG1902	pentaerythritol trinitrate reductase activity
CH53_4093	COG0346	lactoylglutathione lyase activity
CH53_4094	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH53_4095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH53_4096	COG0791	NLP P60 protein
CH53_4097	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH53_4099	COG1609	Transcriptional regulator
CH53_4100	COG0583	DNA-binding transcription factor activity
CH53_4101	COG2814	Major facilitator Superfamily
CH53_4102	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH53_4103	COG0307	riboflavin synthase, alpha
CH53_4104	COG0534	Mate efflux family protein
CH53_4109	COG4238	major outer membrane lipoprotein
CH53_411	COG0586	Pfam SNARE associated Golgi protein
CH53_4110	COG1376	ErfK ybiS ycfS ynhG family protein
CH53_4110	COG1388	LysM domain
CH53_4111	COG2166	iron-sulfur cluster assembly
CH53_4113	COG0719	Fe-S assembly protein
CH53_4114	COG0396	ATPase activity
CH53_4115	COG0719	Fe-S assembly protein
CH53_4116	COG0316	Belongs to the HesB IscA family
CH53_4117	COG2050	protein possibly involved in aromatic compounds catabolism
CH53_4118	COG0247	lactate metabolic process
CH53_4118	COG0277	FAD linked oxidase domain protein
CH53_4119	COG0628	permease
CH53_4120	COG0574	Belongs to the PEP-utilizing enzyme family
CH53_4120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH53_4121	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CH53_4122	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH53_4124	COG3720	iron ion transport
CH53_4125	COG4558	Periplasmic binding protein
CH53_4127	COG0095	Lipoate-protein ligase
CH53_4128	COG0791	NLP P60 protein
CH53_4129	COG2076	Multidrug Resistance protein
CH53_413	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH53_4130	COG2076	Multidrug Resistance protein
CH53_4131	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CH53_4132	COG0726	polysaccharide deacetylase
CH53_4134	COG0463	Glycosyl transferase, family 2
CH53_4135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH53_4136	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH53_4137	COG0386	Belongs to the glutathione peroxidase family
CH53_4138	COG4139	cobalamin transport
CH53_4141	COG0776	regulation of translation
CH53_4145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CH53_4146	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CH53_4155	COG1674	ftsk spoiiie
CH53_418	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH53_4182	COG3646	Phage regulatory protein
CH53_4185	COG3772	lysozyme
CH53_419	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH53_4196	COG0305	Participates in initiation and elongation during chromosome replication
CH53_4212	COG4712	double-strand break repair protein
CH53_4213	COG0629	single-stranded DNA binding
CH53_4226	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH53_4231	COG4249	Peptidase C14 caspase catalytic subunit p20
CH53_4232	COG1811	Na channel or pump
CH53_4233	COG1414	Transcriptional regulator
CH53_4234	COG1129	ABC transporter
CH53_4235	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_4239	COG1070	Carbohydrate kinase
CH53_424	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH53_4240	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CH53_4241	COG3623	hexulose-6-phosphate isomerase
CH53_4247	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH53_4248	COG1121	(ABC) transporter
CH53_4249	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH53_4250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH53_4252	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH53_4252	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH53_4253	COG1703	isobutyryl-CoA mutase activity
CH53_4254	COG1024	Enoyl-CoA hydratase
CH53_4255	COG0583	DNA-binding transcription factor activity
CH53_4256	COG0427	acetyl-CoA hydrolase
CH53_4258	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH53_4259	COG1917	Cupin 2, conserved barrel domain protein
CH53_426	COG1794	racemase activity, acting on amino acids and derivatives
CH53_4261	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_4263	COG1175	transmembrane transport
CH53_4264	COG0395	ABC-type sugar transport system, permease component
CH53_4265	COG3842	ATPase activity
CH53_4267	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH53_4268	COG1988	membrane-bound metal-dependent
CH53_427	COG3706	GGDEF domain
CH53_427	COG0745	RESPONSE REGULATOR receiver
CH53_4270	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH53_4272	COG0823	Involved in the tonB-independent uptake of proteins
CH53_4273	COG2814	Major facilitator Superfamily
CH53_4274	COG0501	Belongs to the peptidase M48B family
CH53_4275	COG0793	Belongs to the peptidase S41A family
CH53_4277	COG1956	GAF domain-containing protein
CH53_4278	COG2995	paraquat-inducible protein a
CH53_4279	COG3008	intermembrane lipid transfer
CH53_428	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH53_4282	COG2203	Gaf domain
CH53_4282	COG3706	GGDEF domain
CH53_4282	COG5001	Diguanylate cyclase
CH53_4282	COG4251	negative regulation of phosphorylation
CH53_429	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CH53_429	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH53_4290	COG0625	glutathione transferase activity
CH53_4294	COG0697	spore germination
CH53_4296	COG1187	pseudouridine synthase activity
CH53_4297	COG0668	transmembrane transport
CH53_4299	COG0589	response to stress
CH53_4305	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CH53_431	COG3101	peptidyl-lysine hydroxylation
CH53_4310	COG1943	Transposase
CH53_4316	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CH53_4316	COG2755	lipolytic protein G-D-S-L family
CH53_432	COG0730	response to heat
CH53_4324	COG0326	Molecular chaperone. Has ATPase activity
CH53_433	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH53_4335	COG1276	copper resistance
CH53_4336	COG2372	response to copper ion
CH53_4337	COG1528	Iron-storage protein
CH53_434	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CH53_4341	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH53_4342	COG1770	oligopeptidase
CH53_4345	COG3141	response to X-ray
CH53_4346	COG0513	Belongs to the DEAD box helicase family
CH53_4347	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CH53_4348	COG3140	Belongs to the UPF0181 family
CH53_435	COG2890	protein-(glutamine-N5) methyltransferase activity
CH53_4350	COG0494	nUDIX hydrolase
CH53_4351	COG1760	l-serine dehydratase
CH53_4352	COG1253	flavin adenine dinucleotide binding
CH53_4353	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_4353	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_4354	COG3715	PTS system
CH53_4355	COG3716	PTS system mannose fructose sorbose family IID component
CH53_4356	COG4811	Protein of unknown function (DUF986)
CH53_4357	COG1971	Probably functions as a manganese efflux pump
CH53_4359	COG5001	Diguanylate cyclase
CH53_4359	COG3447	MASE1 domain protein
CH53_4359	COG5002	protein histidine kinase activity
CH53_436	COG2840	Smr protein MutS2
CH53_4361	COG2226	methyltransferase
CH53_4362	COG0768	penicillin binding
CH53_4364	COG1278	Cold shock
CH53_4366	COG1113	amino acid transport
CH53_437	COG2062	phosphohistidine phosphatase, SixA
CH53_4373	COG2207	Transcriptional regulator
CH53_4377	COG1132	(ABC) transporter
CH53_4379	COG3706	GGDEF domain
CH53_4379	COG4251	negative regulation of phosphorylation
CH53_4379	COG2203	Gaf domain
CH53_4379	COG5001	Diguanylate cyclase
CH53_438	COG1024	Enoyl-CoA hydratase
CH53_438	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH53_4382	COG3755	Protein conserved in bacteria
CH53_4387	COG1733	regulation of RNA biosynthetic process
CH53_4388	COG0702	epimerase
CH53_4389	COG2873	o-acetylhomoserine
CH53_439	COG0183	Belongs to the thiolase family
CH53_4391	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CH53_4393	COG0840	transmembrane signaling receptor activity
CH53_4394	COG3397	chitin binding
CH53_4399	COG0538	isocitrate dehydrogenase activity
CH53_44	COG2771	luxR family
CH53_440	COG3691	Protein conserved in bacteria
CH53_4400	COG1187	pseudouridine synthase activity
CH53_4402	COG0482	sulfurtransferase activity
CH53_4403	COG2915	High frequency lysogenization protein hflD homolog
CH53_4404	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH53_4406	COG0745	RESPONSE REGULATOR receiver
CH53_4408	COG2850	peptidyl-arginine hydroxylation
CH53_4410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH53_4411	COG1940	carbohydrate kinase activity
CH53_4412	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH53_4414	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH53_4415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH53_4416	COG3134	Outer membrane lipoprotein
CH53_4417	COG1252	NADH dehydrogenase
CH53_4418	COG3150	esterase
CH53_4421	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CH53_4422	COG5633	Lipoprotein
CH53_4423	COG0537	adenosine 5'-monophosphoramidase activity
CH53_4424	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_4424	COG1263	PTS System
CH53_4425	COG0084	hydrolase, TatD family'
CH53_4426	COG0470	DNA polymerase III
CH53_443	COG3088	subunit of a heme lyase
CH53_443	COG4235	cytochrome complex assembly
CH53_444	COG4235	cytochrome complex assembly
CH53_444	COG3088	subunit of a heme lyase
CH53_445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH53_446	COG1138	Cytochrome C-type biogenesis protein
CH53_447	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CH53_448	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH53_449	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH53_45	COG3916	Acyl-homoserine-lactone synthase
CH53_450	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH53_453	COG2824	Alkylphosphonate utilization operon protein PhnA
CH53_455	COG0582	viral genome integration into host DNA
CH53_46	COG2066	Belongs to the glutaminase family
CH53_462	COG1695	Transcriptional regulator
CH53_464	COG2723	6-phospho-beta-galactosidase activity
CH53_465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH53_465	COG1263	PTS System
CH53_466	COG1609	Transcriptional regulator
CH53_468	COG2353	YceI-like domain
CH53_469	COG3038	cytochrome b561
CH53_47	COG0531	amino acid
CH53_471	COG0626	cystathionine gamma-synthase activity
CH53_476	COG1127	ABC transporter
CH53_477	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH53_48	COG0076	glutamate decarboxylase activity
CH53_481	COG0531	amino acid
CH53_482	COG2951	lytic endotransglycosylase activity
CH53_488	COG2723	6-phospho-beta-galactosidase activity
CH53_491	COG0243	molybdopterin cofactor binding
CH53_492	COG0437	4 iron, 4 sulfur cluster binding
CH53_493	COG3302	dmso reductase anchor subunit
CH53_494	COG3381	protein complex oligomerization
CH53_496	COG1598	PFAM Uncharacterised protein family UPF0150
CH53_497	COG3038	cytochrome b561
CH53_498	COG0436	Aminotransferase
CH53_501	COG3275	phosphorelay sensor kinase activity
CH53_502	COG3279	Response regulator of the LytR AlgR family
CH53_503	COG2223	nitrite transmembrane transporter activity
CH53_504	COG0837	glucose binding
CH53_507	COG0667	Aldo Keto reductase
CH53_509	COG1914	H( )-stimulated, divalent metal cation uptake system
CH53_510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH53_515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH53_52	COG1388	LysM domain
CH53_52	COG1470	cell adhesion involved in biofilm formation
CH53_520	COG3530	Putative quorum-sensing-regulated virulence factor
CH53_521	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH53_523	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CH53_524	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CH53_525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_527	COG2190	(PTS) system
CH53_528	COG2205	protein histidine kinase activity
CH53_529	COG0745	RESPONSE REGULATOR receiver
CH53_530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_542	COG4208	sulfate ABC transporter
CH53_543	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH53_544	COG4150	thiosulfate binding
CH53_545	COG2837	iron assimilation
CH53_547	COG3111	PFAM Bacterial OB fold (BOF) protein
CH53_548	COG0456	acetyltransferase
CH53_549	COG0408	coproporphyrinogen oxidase activity
CH53_550	COG1671	Belongs to the UPF0178 family
CH53_552	COG0494	nUDIX hydrolase
CH53_555	COG3005	denitrification pathway
CH53_556	COG3043	anaerobic respiration
CH53_557	COG0243	molybdopterin cofactor binding
CH53_558	COG3062	negative regulation of establishment of protein localization
CH53_559	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_559	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_560	COG2197	response regulator
CH53_562	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH53_564	COG1393	Belongs to the ArsC family
CH53_565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH53_566	COG1876	peptidase activity
CH53_568	COG0400	carboxylic ester hydrolase activity
CH53_57	COG0549	Belongs to the carbamate kinase family
CH53_571	COG1444	tRNA N-acetyltransferase activity
CH53_573	COG2321	neutral zinc metallopeptidase
CH53_575	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH53_576	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH53_577	COG2716	regulation of RNA biosynthetic process
CH53_578	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH53_579	COG0628	permease
CH53_580	COG4783	chaperone-mediated protein folding
CH53_581	COG1393	Belongs to the ArsC family
CH53_582	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH53_583	COG2233	PERMEase
CH53_585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CH53_586	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH53_587	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH53_59	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH53_590	COG0581	inorganic phosphate transmembrane transporter activity
CH53_591	COG0573	inorganic phosphate transmembrane transporter activity
CH53_592	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH53_593	COG0248	Ppx GppA phosphatase
CH53_595	COG2239	Acts as a magnesium transporter
CH53_598	COG0443	Heat shock 70 kDa protein
CH53_599	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_6	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_60	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH53_601	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH53_602	COG2205	protein histidine kinase activity
CH53_603	COG0745	RESPONSE REGULATOR receiver
CH53_604	COG3422	double-strand break repair
CH53_606	COG1597	lipid kinase activity
CH53_607	COG3730	PTS system glucitol sorbitol-specific
CH53_61	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CH53_610	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_611	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH53_612	COG1349	DNA-binding transcription factor activity
CH53_616	COG0351	phosphomethylpyrimidine kinase
CH53_62	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH53_620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CH53_620	COG0519	Catalyzes the synthesis of GMP from XMP
CH53_621	COG0516	GMP reductase activity
CH53_621	COG0517	IMP dehydrogenase activity
CH53_623	COG1645	bacterial-type flagellum-dependent swarming motility
CH53_626	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH53_627	COG2976	Protein conserved in bacteria
CH53_63	COG3257	ureidoglycine aminohydrolase activity
CH53_630	COG1426	Protein conserved in bacteria
CH53_632	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CH53_635	COG4953	penicillin-binding protein 1C
CH53_636	COG2373	Large extracellular alpha-helical protein
CH53_637	COG3468	outer membrane autotransporter barrel domain protein
CH53_64	COG1929	Belongs to the glycerate kinase type-1 family
CH53_640	COG2975	iron-sulfur cluster assembly
CH53_641	COG0633	Ferredoxin
CH53_642	COG0443	Heat shock 70 kDa protein
CH53_643	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH53_645	COG0822	iron-sulfur transferase activity
CH53_647	COG1959	2 iron, 2 sulfur cluster binding
CH53_648	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CH53_649	COG0483	inositol monophosphate 1-phosphatase activity
CH53_65	COG2233	PERMEase
CH53_650	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH53_651	COG3683	transport system, periplasmic component
CH53_652	COG2814	Major facilitator Superfamily
CH53_653	COG3711	transcriptional antiterminator
CH53_655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH53_655	COG1017	nitric oxide dioxygenase activity
CH53_656	COG2188	Transcriptional regulator
CH53_658	COG3457	Alanine racemase
CH53_659	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CH53_662	COG0347	Belongs to the P(II) protein family
CH53_663	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH53_663	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH53_664	COG2204	response regulator
CH53_665	COG3170	Tfp pilus assembly protein FimV
CH53_666	COG2205	protein histidine kinase activity
CH53_669	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CH53_67	COG1953	Uracil, thiamine, allantoin
CH53_670	COG0590	tRNA wobble adenosine to inosine editing
CH53_672	COG0560	Phosphoserine phosphatase
CH53_674	COG1737	Transcriptional regulator
CH53_675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH53_676	COG0736	holo-[acyl-carrier-protein] synthase activity
CH53_677	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH53_678	COG1381	Involved in DNA repair and RecF pathway recombination
CH53_679	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CH53_68	COG2084	Dehydrogenase
CH53_681	COG0681	Belongs to the peptidase S26 family
CH53_682	COG0481	GTPase activity
CH53_684	COG3086	response to oxidative stress
CH53_685	COG3026	antisigma factor binding
CH53_686	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH53_688	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH53_689	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CH53_69	COG3622	Belongs to the hyi family
CH53_690	COG0513	Belongs to the DEAD box helicase family
CH53_693	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CH53_694	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CH53_695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CH53_696	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH53_697	COG0497	DNA recombination
CH53_698	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH53_7	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH53_70	COG3960	tartronate-semialdehyde synthase activity
CH53_700	COG2867	negative regulation of translational initiation
CH53_701	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CH53_704	COG3778	Protein conserved in bacteria
CH53_71	COG1414	Transcriptional regulator
CH53_711	COG3394	polysaccharide catabolic process
CH53_712	COG1917	Cupin 2, conserved barrel domain protein
CH53_712	COG2169	Transcriptional regulator
CH53_713	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH53_714	COG2723	6-phospho-beta-galactosidase activity
CH53_715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH53_716	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH53_717	COG2133	pyrroloquinoline quinone binding
CH53_718	COG0667	Aldo Keto reductase
CH53_720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH53_721	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH53_723	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH53_724	COG4413	Urea transporter
CH53_726	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH53_727	COG0830	nickel cation binding
CH53_728	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CH53_729	COG0804	urea catabolic process
CH53_73	COG0583	DNA-binding transcription factor activity
CH53_732	COG1124	(ABC) transporter
CH53_734	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH53_735	COG0601	transmembrane transport
CH53_74	COG3706	GGDEF domain
CH53_74	COG0745	RESPONSE REGULATOR receiver
CH53_741	COG1278	Cold shock
CH53_745	COG3708	Transcriptional regulator
CH53_745	COG2207	Transcriptional regulator
CH53_749	COG4575	ribosome binding
CH53_75	COG4999	Histidine kinase
CH53_75	COG3850	Histidine kinase
CH53_75	COG3437	response regulator, receiver
CH53_75	COG2205	protein histidine kinase activity
CH53_751	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH53_752	COG1780	Probably involved in ribonucleotide reductase function
CH53_754	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH53_756	COG4176	ABC-type proline glycine betaine transport system permease component
CH53_757	COG2113	Glycine betaine
CH53_763	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH53_765	COG2226	methyltransferase
CH53_766	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH53_767	COG0741	lytic transglycosylase activity
CH53_767	COG1388	LysM domain
CH53_768	COG3021	interspecies interaction between organisms
CH53_769	COG2814	Major facilitator Superfamily
CH53_770	COG0583	DNA-binding transcription factor activity
CH53_772	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH53_783	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CH53_794	COG0542	response to heat
CH53_796	COG0564	pseudouridine synthase activity
CH53_797	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH53_798	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH53_799	COG1605	Chorismate mutase
CH53_799	COG0077	Prephenate dehydratase
CH53_80	COG1215	transferase activity, transferring glycosyl groups
CH53_800	COG0287	Prephenate dehydrogenase
CH53_800	COG1605	Chorismate mutase
CH53_801	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH53_802	COG3279	Response regulator of the LytR AlgR family
CH53_803	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH53_804	COG3137	Salt-induced outer membrane protein
CH53_805	COG0335	large ribosomal subunit rRNA binding
CH53_806	COG0336	Belongs to the RNA methyltransferase TrmD family
CH53_808	COG0228	four-way junction DNA binding
CH53_809	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH53_810	COG4137	Cytochrome C assembly protein
CH53_811	COG4536	flavin adenine dinucleotide binding
CH53_812	COG1854	S-ribosylhomocysteine lyase activity
CH53_813	COG2918	glutathione biosynthetic process
CH53_814	COG1238	metal cluster binding
CH53_815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH53_82	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CH53_820	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH53_821	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH53_822	COG2137	regulation of response to DNA damage stimulus
CH53_823	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH53_828	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH53_829	COG3958	Transketolase
CH53_83	COG1366	Belongs to the anti-sigma-factor antagonist family
CH53_830	COG3959	Transketolase, thiamine diphosphate binding domain
CH53_831	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_832	COG1129	ABC transporter
CH53_834	COG1609	Transcriptional regulator
CH53_836	COG3381	protein complex oligomerization
CH53_837	COG3302	dmso reductase anchor subunit
CH53_838	COG0437	4 iron, 4 sulfur cluster binding
CH53_839	COG0243	molybdopterin cofactor binding
CH53_84	COG0745	RESPONSE REGULATOR receiver
CH53_840	COG1454	alcohol dehydrogenase
CH53_841	COG0235	Class ii aldolase
CH53_842	COG0738	Major facilitator superfamily
CH53_844	COG1070	Carbohydrate kinase
CH53_846	COG1349	DNA-binding transcription factor activity
CH53_847	COG0235	Class ii aldolase
CH53_849	COG1349	DNA-binding transcription factor activity
CH53_852	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_853	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH53_854	COG3623	hexulose-6-phosphate isomerase
CH53_855	COG1070	Carbohydrate kinase
CH53_856	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH53_856	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH53_858	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH53_859	COG4177	L-phenylalanine transmembrane transporter activity
CH53_86	COG0058	SHG alpha-glucan phosphorylase activity
CH53_860	COG1137	ATPase activity
CH53_861	COG0410	ABC transporter
CH53_872	COG0640	Transcriptional regulator
CH53_873	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CH53_874	COG3158	transport of potassium into the cell
CH53_875	COG3048	D-serine ammonia-lyase activity
CH53_876	COG2610	gluconate transmembrane transporter activity
CH53_877	COG0583	DNA-binding transcription factor activity
CH53_878	COG4608	Belongs to the ABC transporter superfamily
CH53_879	COG0444	Belongs to the ABC transporter superfamily
CH53_881	COG0601	transmembrane transport
CH53_882	COG0747	negative chemotaxis
CH53_883	COG4948	Mandelate Racemase Muconate Lactonizing
CH53_884	COG1028	Short-chain dehydrogenase reductase Sdr
CH53_888	COG1538	Outer membrane efflux protein
CH53_889	COG1136	(ABC) transporter
CH53_889	COG0577	efflux transmembrane transporter activity
CH53_890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH53_893	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH53_896	COG3539	Fimbrial protein
CH53_897	COG3539	Fimbrial protein
CH53_9	COG0416	fatty acid biosynthetic process
CH53_900	COG3121	Chaperone
CH53_901	COG3188	usher protein
CH53_918	COG0084	hydrolase, TatD family'
CH53_923	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH53_924	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH53_925	COG1388	LysM domain
CH53_925	COG4942	peptidase
CH53_926	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CH53_927	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CH53_928	COG0585	pseudouridine synthase activity
CH53_929	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CH53_93	COG3121	Chaperone
CH53_931	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CH53_933	COG0765	amino acid transport
CH53_936	COG0529	Catalyzes the synthesis of activated sulfate
CH53_937	COG2895	sulfate adenylyltransferase (ATP) activity
CH53_938	COG0175	sulfate reduction
CH53_939	COG1648	precorrin-2 dehydrogenase activity
CH53_939	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH53_940	COG2234	aminopeptidase activity
CH53_943	COG0175	sulfate reduction
CH53_944	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH53_945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CH53_946	COG0720	synthase
CH53_947	COG0602	queuosine metabolic process
CH53_949	COG0148	phosphopyruvate hydratase activity
CH53_950	COG0504	CTP synthase activity
CH53_951	COG3956	TIGRFAM MazG family protein
CH53_952	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH53_953	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH53_955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH53_956	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CH53_957	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH53_959	COG2860	membrane
CH53_96	COG3121	Chaperone
CH53_960	COG0316	Belongs to the HesB IscA family
CH53_962	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CH53_964	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH53_965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH53_966	COG1120	ATPase activity
CH53_967	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH53_968	COG1643	Atp-dependent helicase
CH53_969	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CH53_97	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CH53_970	COG1489	DNA binding
CH53_971	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH53_973	COG0617	tRNA 3'-terminal CCA addition
CH53_974	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH53_975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CH53_976	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CH53_978	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CH53_979	COG0726	polysaccharide deacetylase
CH53_980	COG0842	Transport permease protein
CH53_981	COG1131	(ABC) transporter
CH53_982	COG0288	reversible hydration of carbon dioxide
CH53_983	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH53_984	COG2132	Multicopper oxidase
CH53_986	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CH53_987	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CH53_989	COG3112	Uncharacterised protein family (UPF0231)
CH53_990	COG1049	propionate catabolic process, 2-methylcitrate cycle
CH53_993	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH53_994	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH53_995	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH53_996	COG2186	Transcriptional regulator
CH53_997	COG1113	amino acid transport
CH53_998	COG3725	Membrane protein required for beta-lactamase induction