locus-tag	class	description
HRD70_00005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HRD70_00010	COG2171	N-acyltransferase activity
HRD70_00025	COG0564	pseudouridine synthase activity
HRD70_00030	COG3098	single-species biofilm formation
HRD70_00045	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRD70_00045	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRD70_00050	COG1611	Belongs to the LOG family
HRD70_00055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD70_00060	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HRD70_00065	COG2363	Small membrane protein
HRD70_00070	COG0583	DNA-binding transcription factor activity
HRD70_00085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRD70_00090	COG2166	iron-sulfur cluster assembly
HRD70_00095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HRD70_00100	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HRD70_00120	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRD70_00125	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HRD70_00125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRD70_00130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRD70_00140	COG1025	Belongs to the peptidase M16 family
HRD70_00145	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HRD70_00150	COG4967	type IV pilus modification protein PilV
HRD70_00175	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRD70_00185	COG1051	belongs to the nudix hydrolase family
HRD70_00190	COG3066	DNA modification
HRD70_00195	COG0861	Integral membrane protein TerC family
HRD70_00200	COG0667	Aldo Keto reductase
HRD70_00205	COG0477	Major facilitator Superfamily
HRD70_00210	COG0318	PFAM AMP-dependent synthetase and ligase
HRD70_00210	COG0204	Acyl-transferase
HRD70_00220	COG1609	Transcriptional regulator
HRD70_00230	COG0583	DNA-binding transcription factor activity
HRD70_00235	COG2814	Major facilitator Superfamily
HRD70_00240	COG0583	DNA-binding transcription factor activity
HRD70_00255	COG0840	transmembrane signaling receptor activity
HRD70_00305	COG2165	general secretion pathway protein
HRD70_00335	COG0288	reversible hydration of carbon dioxide
HRD70_00340	COG1733	regulation of RNA biosynthetic process
HRD70_00345	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_00360	COG0484	heat shock protein binding
HRD70_00365	COG1609	Transcriptional regulator
HRD70_00370	COG2271	Major facilitator Superfamily
HRD70_00385	COG1522	sequence-specific DNA binding
HRD70_00390	COG3706	GGDEF domain
HRD70_00395	COG1309	transcriptional regulator
HRD70_00405	COG4319	ketosteroid isomerase
HRD70_00440	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD70_00450	COG1940	carbohydrate kinase activity
HRD70_00470	COG4974	Belongs to the 'phage' integrase family
HRD70_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRD70_00490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRD70_00495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRD70_00500	COG4974	Belongs to the 'phage' integrase family
HRD70_00505	COG0716	FMN binding
HRD70_00510	COG4452	Inner membrane protein CreD
HRD70_00515	COG2205	protein histidine kinase activity
HRD70_00520	COG0745	RESPONSE REGULATOR receiver
HRD70_00535	COG0354	folic acid binding
HRD70_00540	COG1272	protein, Hemolysin III
HRD70_00550	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_00560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRD70_00560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRD70_00565	COG0509	glycine decarboxylation via glycine cleavage system
HRD70_00570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRD70_00575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD70_00580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD70_00585	COG0006	proline dipeptidase activity
HRD70_00590	COG3079	Belongs to the UPF0149 family
HRD70_00595	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HRD70_00605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRD70_00610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD70_00615	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HRD70_00620	COG0583	DNA-binding transcription factor activity
HRD70_00630	COG1279	arginine transmembrane transporter activity
HRD70_00640	COG0191	fructose-bisphosphate aldolase activity
HRD70_00645	COG0126	phosphoglycerate kinase activity
HRD70_00650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRD70_00655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRD70_00660	COG0501	Belongs to the peptidase M48B family
HRD70_00670	COG1166	arginine decarboxylase activity
HRD70_00675	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRD70_00690	COG0640	Transcriptional regulator
HRD70_00695	COG3091	SprT-like family
HRD70_00700	COG2356	endonuclease I
HRD70_00705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRD70_00710	COG0189	ligase activity
HRD70_00715	COG1678	Uncharacterized ACR, COG1678
HRD70_00720	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRD70_00725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD70_00735	COG2805	Type II/IV secretion system protein
HRD70_00740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRD70_00745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRD70_00750	COG0762	integral membrane protein
HRD70_00755	COG1872	DUF167
HRD70_00760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRD70_00765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRD70_00780	COG3171	Protein conserved in bacteria
HRD70_00785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRD70_00790	COG1194	a g-specific adenine glycosylase
HRD70_00795	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HRD70_00800	COG0741	lytic transglycosylase activity
HRD70_00810	COG1982	Orn Lys Arg decarboxylase major
HRD70_00820	COG1882	Formate acetyltransferase
HRD70_00825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HRD70_00830	COG0814	amino acid
HRD70_00835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRD70_00855	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HRD70_00860	COG0366	Alpha amylase catalytic
HRD70_00865	COG0395	ABC-type sugar transport system, permease component
HRD70_00870	COG1175	transmembrane transport
HRD70_00880	COG1609	Transcriptional regulator
HRD70_00890	COG3842	ATPase activity
HRD70_00975	COG3179	chitinase
HRD70_00995	COG2885	chlorophyll binding
HRD70_01020	COG4977	sequence-specific DNA binding
HRD70_01020	COG1917	Cupin 2, conserved barrel domain protein
HRD70_01025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRD70_01040	COG1289	transmembrane transporter activity
HRD70_01065	COG0024	Methionine aminopeptidase
HRD70_01070	COG4604	ABC transporter, ATP-binding protein
HRD70_01075	COG4605	iron ion homeostasis
HRD70_01085	COG4607	ABC-type enterochelin transport system periplasmic component
HRD70_01100	COG0477	Major facilitator Superfamily
HRD70_01105	COG1609	Transcriptional regulator
HRD70_01115	COG1283	sodium-dependent phosphate transmembrane transporter activity
HRD70_01120	COG2195	Cleaves the N-terminal amino acid of tripeptides
HRD70_01125	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HRD70_01145	COG3961	Belongs to the TPP enzyme family
HRD70_01155	COG0477	Major facilitator Superfamily
HRD70_01165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD70_01170	COG5001	Diguanylate cyclase
HRD70_01180	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HRD70_01185	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HRD70_01190	COG0309	Hydrogenase expression formation protein (HypE)
HRD70_01195	COG0409	Hydrogenase expression formation protein
HRD70_01200	COG0298	carbon dioxide binding
HRD70_01205	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRD70_01215	COG1773	rubredoxin
HRD70_01220	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HRD70_01225	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HRD70_01230	COG5557	Pfam Polysulphide reductase, NrfD
HRD70_01235	COG0437	4 iron, 4 sulfur cluster binding
HRD70_01240	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HRD70_01245	COG3133	Outer membrane lipoprotein
HRD70_01265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD70_01270	COG2271	Major facilitator Superfamily
HRD70_01275	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_01280	COG3433	isochorismatase activity
HRD70_01280	COG1535	isochorismatase
HRD70_01285	COG1021	2,3-dihydroxybenzoate-AMP ligase
HRD70_01290	COG1169	isochorismate synthase
HRD70_01295	COG4592	Periplasmic binding protein
HRD70_01305	COG1120	ATPase activity
HRD70_01310	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD70_01315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD70_01325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRD70_01340	COG4774	siderophore transport
HRD70_01360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD70_01365	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD70_01395	COG4964	Belongs to the GSP D family
HRD70_01445	COG0848	biopolymer transport protein
HRD70_01460	COG0586	Pfam SNARE associated Golgi protein
HRD70_01465	COG2207	Transcriptional regulator
HRD70_01470	COG1979	alcohol dehydrogenase
HRD70_01475	COG0656	L-ascorbic acid biosynthetic process
HRD70_01485	COG2132	Multicopper oxidase
HRD70_01490	COG0204	Acyl-transferase
HRD70_01500	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD70_01505	COG3715	PTS system
HRD70_01510	COG3716	PTS system mannose fructose sorbose family IID component
HRD70_01530	COG0745	RESPONSE REGULATOR receiver
HRD70_01535	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRD70_01540	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HRD70_01555	COG3150	esterase
HRD70_01560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HRD70_01565	COG3151	Protein conserved in bacteria
HRD70_01570	COG0494	nUDIX hydrolase
HRD70_01575	COG1538	Outer membrane efflux protein
HRD70_01580	COG5463	Belongs to the UPF0441 family
HRD70_01585	COG0754	glutathionylspermidine amidase activity
HRD70_01590	COG3384	dioxygenase
HRD70_01595	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRD70_01605	COG0531	amino acid
HRD70_01610	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HRD70_01610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRD70_01615	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HRD70_01620	COG3025	triphosphatase activity
HRD70_01625	COG4991	sh3 domain protein
HRD70_01630	COG0617	tRNA 3'-terminal CCA addition
HRD70_01635	COG1968	undecaprenyl-diphosphatase activity
HRD70_01640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HRD70_01645	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HRD70_01650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRD70_01655	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRD70_01660	COG0358	DNA primase activity
HRD70_01685	COG3876	Protein conserved in bacteria
HRD70_01695	COG1472	Belongs to the glycosyl hydrolase 3 family
HRD70_01705	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HRD70_01710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD70_01710	COG1263	PTS System
HRD70_01720	COG0531	amino acid
HRD70_01725	COG0076	glutamate decarboxylase activity
HRD70_01735	COG2814	Major facilitator Superfamily
HRD70_01740	COG3247	response to pH
HRD70_01755	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRD70_01755	COG1902	pentaerythritol trinitrate reductase activity
HRD70_01760	COG2813	Specifically methylates the guanine in position
HRD70_01770	COG1451	nucleotide metabolic process
HRD70_01775	COG0673	inositol 2-dehydrogenase activity
HRD70_01780	COG0861	Integral membrane protein TerC family
HRD70_01785	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HRD70_01795	COG2721	sulfolactate sulfo-lyase activity
HRD70_01800	COG0246	Mannitol dehydrogenase
HRD70_01805	COG1904	glucuronate isomerase
HRD70_01810	COG2271	Major facilitator Superfamily
HRD70_01825	COG0586	Pfam SNARE associated Golgi protein
HRD70_01840	COG4575	ribosome binding
HRD70_01845	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HRD70_01855	COG2259	Doxx family
HRD70_01860	COG0435	Glutathione S-transferase
HRD70_01865	COG0583	DNA-binding transcription factor activity
HRD70_01870	COG1741	Belongs to the pirin family
HRD70_01875	COG1064	alcohol dehydrogenase
HRD70_01880	COG4221	oxidoreductase activity
HRD70_01890	COG0667	Aldo Keto reductase
HRD70_01930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRD70_01940	COG0792	nuclease activity
HRD70_01945	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HRD70_01950	COG2823	Periplasmic or secreted lipoprotein
HRD70_01955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD70_01960	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HRD70_01965	COG0784	Response regulator, receiver
HRD70_01965	COG2198	Histidine kinase
HRD70_01965	COG5002	protein histidine kinase activity
HRD70_01970	COG1242	4 iron, 4 sulfur cluster binding
HRD70_01975	COG0070	glutamate synthase
HRD70_01975	COG0069	glutamate synthase activity
HRD70_01975	COG0067	glutamate synthase
HRD70_01980	COG0493	'glutamate synthase
HRD70_01990	COG2969	positive regulation of protein catabolic process
HRD70_01995	COG0625	glutathione transferase activity
HRD70_02000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRD70_02005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRD70_02010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HRD70_02015	COG3105	Protein conserved in bacteria
HRD70_02020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD70_02025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD70_02030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRD70_02035	COG5007	Belongs to the BolA IbaG family
HRD70_02040	COG3113	response to antibiotic
HRD70_02045	COG2854	intermembrane phospholipid transfer
HRD70_02050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRD70_02055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRD70_02060	COG1127	ABC transporter
HRD70_02065	COG0530	calcium, potassium:sodium antiporter activity
HRD70_02070	COG0517	IMP dehydrogenase activity
HRD70_02070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HRD70_02075	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HRD70_02080	COG3117	lipopolysaccharide transmembrane transporter activity
HRD70_02085	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HRD70_02090	COG1137	ATPase activity
HRD70_02095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HRD70_02110	COG1660	Displays ATPase and GTPase activities
HRD70_02115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD70_02120	COG0540	Belongs to the ATCase OTCase family
HRD70_02125	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HRD70_02135	COG0366	Alpha amylase catalytic
HRD70_02140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD70_02140	COG1263	PTS System
HRD70_02155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD70_02155	COG3711	transcriptional antiterminator
HRD70_02160	COG2706	6-phosphogluconolactonase activity
HRD70_02175	COG3964	amidohydrolase
HRD70_02205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRD70_02210	COG3783	Cytochrome b(562)
HRD70_02215	COG0312	modulator of DNA gyrase
HRD70_02220	COG3028	Belongs to the UPF0307 family
HRD70_02225	COG2732	(Barnase) inhibitor
HRD70_02235	COG1012	belongs to the aldehyde dehydrogenase family
HRD70_02240	COG1289	transmembrane transporter activity
HRD70_02245	COG1566	PFAM secretion protein HlyD family protein
HRD70_02255	COG0583	DNA-binding transcription factor activity
HRD70_02260	COG0312	modulator of DNA gyrase
HRD70_02265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD70_02270	COG3164	Protein of unknown function
HRD70_02275	COG1530	ribonuclease E activity
HRD70_02280	COG0424	maF-like protein
HRD70_02285	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HRD70_02290	COG1792	Involved in formation and maintenance of cell shape
HRD70_02295	COG1077	Cell shape determining protein MreB Mrl
HRD70_02300	COG2200	EAL domain
HRD70_02300	COG2199	diguanylate cyclase activity
HRD70_02305	COG0604	alcohol dehydrogenase
HRD70_02315	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HRD70_02320	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HRD70_02325	COG0511	ligase activity, forming carbon-carbon bonds
HRD70_02330	COG0439	Biotin carboxylase
HRD70_02335	COG3924	membrane
HRD70_02340	COG4145	pantothenate transmembrane transporter activity
HRD70_02345	COG2264	protein methyltransferase activity
HRD70_02350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD70_02355	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HRD70_02365	COG3706	GGDEF domain
HRD70_02370	COG3133	Outer membrane lipoprotein
HRD70_02375	COG1278	Cold shock
HRD70_02380	COG1278	Cold shock
HRD70_02385	COG1278	Cold shock
HRD70_02390	COG0471	metal ion transport
HRD70_02395	COG1560	Kdo2-lipid A biosynthetic process
HRD70_02410	COG1380	Effector of murein hydrolase LrgA
HRD70_02415	COG0583	DNA-binding transcription factor activity
HRD70_02420	COG0025	NhaP-type Na H and K H
HRD70_02425	COG2252	PERMEase
HRD70_02440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRD70_02445	COG2315	Protein conserved in bacteria
HRD70_02450	COG1448	Aminotransferase
HRD70_02465	COG0604	alcohol dehydrogenase
HRD70_02475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD70_02480	COG0735	belongs to the Fur family
HRD70_02485	COG3237	CsbD-like
HRD70_02490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRD70_02495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HRD70_02500	COG2937	Belongs to the GPAT DAPAT family
HRD70_02505	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HRD70_02510	COG3161	chorismate lyase activity
HRD70_02525	COG4580	involved in the transport of maltose and maltodextrins
HRD70_02535	COG2182	Extracellular solute-binding protein
HRD70_02540	COG1175	transmembrane transport
HRD70_02545	COG3833	ABC-type maltose transport systems, permease component
HRD70_02550	COG3223	Belongs to the PsiE family
HRD70_02560	COG0527	aspartate kinase activity
HRD70_02590	COG3852	Histidine kinase
HRD70_02595	COG2204	response regulator
HRD70_02600	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HRD70_02605	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HRD70_02610	COG2031	fatty acid transporter
HRD70_02615	COG0183	Belongs to the thiolase family
HRD70_02620	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HRD70_02625	COG2224	Isocitrate lyase
HRD70_02630	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HRD70_02635	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HRD70_02680	COG0138	bifunctional purine biosynthesis protein purh
HRD70_02685	COG0151	Belongs to the GarS family
HRD70_02705	COG1515	deoxyribonuclease V activity
HRD70_02710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HRD70_02715	COG2816	NAD+ diphosphatase activity
HRD70_02720	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HRD70_02735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRD70_02740	COG2104	thiamine diphosphate biosynthetic process
HRD70_02745	COG2022	thiamine diphosphate biosynthetic process
HRD70_02760	COG0085	RNA polymerase activity
HRD70_02770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRD70_02775	COG0081	regulation of translation
HRD70_02780	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRD70_02785	COG0250	Participates in transcription elongation, termination and antitermination
HRD70_02795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRD70_02830	COG1072	(Pantothenic acid kinase))
HRD70_02870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HRD70_02875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRD70_02880	COG0009	L-threonylcarbamoyladenylate synthase
HRD70_02885	COG0551	DNA topoisomerase type I activity
HRD70_02895	COG0758	DNA mediated transformation
HRD70_02900	COG0242	peptide deformylase activity
HRD70_02905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRD70_02910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRD70_02910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRD70_02920	COG1970	mechanosensitive ion channel activity
HRD70_02925	COG3036	rescue of stalled ribosome
HRD70_02930	COG0789	Transcriptional regulator
HRD70_02940	COG0203	ribosomal protein L17
HRD70_02945	COG0202	RNA polymerase activity
HRD70_02950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRD70_02955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRD70_02960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRD70_02965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRD70_02970	COG0201	protein transport
HRD70_02975	COG0200	Binds to the 23S rRNA
HRD70_02980	COG1841	ribosomal large subunit assembly
HRD70_02985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRD70_02990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRD70_02995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRD70_03005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRD70_03015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRD70_03020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRD70_03025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRD70_03030	COG0255	Belongs to the universal ribosomal protein uL29 family
HRD70_03035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRD70_03040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRD70_03045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRD70_03050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRD70_03060	COG0089	rRNA binding
HRD70_03070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRD70_03075	COG0051	transcription antitermination factor activity, RNA binding
HRD70_03090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRD70_03100	COG0049	tRNA binding
HRD70_03105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRD70_03110	COG2168	tRNA wobble position uridine thiolation
HRD70_03115	COG2923	Belongs to the DsrF TusC family
HRD70_03120	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HRD70_03125	COG2964	Protein conserved in bacteria
HRD70_03135	COG2900	Belongs to the SlyX family
HRD70_03140	COG1047	Peptidyl-prolyl cis-trans
HRD70_03145	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HRD70_03155	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRD70_03160	COG0488	(ABC) transporter
HRD70_03170	COG2175	clavaminate synthase activity
HRD70_03175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRD70_03185	COG4521	taurine ABC transporter
HRD70_03200	COG0429	hydrolase of the alpha beta-hydrolase fold
HRD70_03205	COG3089	Belongs to the UPF0270 family
HRD70_03210	COG3954	Phosphoribulokinase
HRD70_03215	COG1765	OsmC-like protein
HRD70_03225	COG1289	transmembrane transporter activity
HRD70_03245	COG0433	COG0433 Predicted ATPase
HRD70_03250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRD70_03255	COG1486	melibiose metabolic process
HRD70_03265	COG0738	Major facilitator superfamily
HRD70_03270	COG0402	S-adenosylhomocysteine deaminase activity
HRD70_03275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD70_03290	COG1648	precorrin-2 dehydrogenase activity
HRD70_03290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRD70_03295	COG0180	Tryptophanyl-tRNA synthetase
HRD70_03305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRD70_03325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRD70_03355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRD70_03360	COG0494	nUDIX hydrolase
HRD70_03370	COG1011	Hydrolase
HRD70_03375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HRD70_03385	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HRD70_03395	COG0745	RESPONSE REGULATOR receiver
HRD70_03400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRD70_03405	COG2183	response to ionizing radiation
HRD70_03410	COG1918	ferrous iron import across plasma membrane
HRD70_03415	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HRD70_03430	COG0596	Alpha beta hydrolase
HRD70_03435	COG1040	competence protein
HRD70_03440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HRD70_03440	COG0316	Belongs to the HesB IscA family
HRD70_03445	COG1640	4-alpha-glucanotransferase
HRD70_03450	COG0058	SHG alpha-glucan phosphorylase activity
HRD70_03455	COG2909	trisaccharide binding
HRD70_03465	COG0705	Rhomboid family
HRD70_03470	COG1349	DNA-binding transcription factor activity
HRD70_03475	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRD70_03480	COG0058	SHG alpha-glucan phosphorylase activity
HRD70_03485	COG0297	glycogen (starch) synthase activity
HRD70_03495	COG1523	belongs to the glycosyl hydrolase 13 family
HRD70_03500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRD70_03505	COG3275	phosphorelay sensor kinase activity
HRD70_03510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRD70_03515	COG2095	MarC family integral membrane protein
HRD70_03520	COG3265	gluconokinase activity
HRD70_03525	COG2610	gluconate transmembrane transporter activity
HRD70_03530	COG1609	Transcriptional regulator
HRD70_03535	COG1741	Belongs to the pirin family
HRD70_03540	COG1247	-acetyltransferase
HRD70_03545	COG1082	Xylose isomerase domain protein TIM barrel
HRD70_03550	COG1082	Xylose isomerase domain protein TIM barrel
HRD70_03555	COG0673	inositol 2-dehydrogenase activity
HRD70_03560	COG3962	Belongs to the TPP enzyme family
HRD70_03575	COG3718	enzyme involved in inositol metabolism
HRD70_03590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HRD70_03600	COG0561	phosphatase activity
HRD70_03605	COG2081	HI0933 family
HRD70_03610	COG0306	phosphate transporter
HRD70_03620	COG0589	response to stress
HRD70_03635	COG0742	ribosomal rna small subunit methyltransferase
HRD70_03645	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HRD70_03650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD70_03660	COG1396	sequence-specific DNA binding
HRD70_03665	COG1295	ribonuclease BN
HRD70_03670	COG2134	cdp-diacylglycerol pyrophosphatase
HRD70_03675	COG2982	Protein involved in outer membrane biogenesis
HRD70_03680	COG2200	EAL domain
HRD70_03685	COG1942	4-Oxalocrotonate Tautomerase
HRD70_03690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD70_03695	COG0612	Peptidase, M16
HRD70_03700	COG1301	dicarboxylic acid transport
HRD70_03710	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD70_03715	COG2200	EAL domain
HRD70_03715	COG2199	diguanylate cyclase activity
HRD70_03720	COG3118	belongs to the thioredoxin family
HRD70_03720	COG0457	Tetratricopeptide repeat
HRD70_03725	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HRD70_03735	COG1215	transferase activity, transferring glycosyl groups
HRD70_03740	COG1192	Involved in chromosome partitioning
HRD70_03760	COG2194	sulfuric ester hydrolase activity
HRD70_03765	COG4608	Belongs to the ABC transporter superfamily
HRD70_03770	COG0444	Belongs to the ABC transporter superfamily
HRD70_03775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD70_03780	COG0601	transmembrane transport
HRD70_03785	COG0747	negative chemotaxis
HRD70_03790	COG3210	domain, Protein
HRD70_03795	COG2831	hemolysin activation secretion protein
HRD70_03800	COG3210	domain, Protein
HRD70_03810	COG2271	Major facilitator Superfamily
HRD70_03815	COG3851	Histidine kinase
HRD70_03820	COG2197	response regulator
HRD70_03825	COG2194	sulfuric ester hydrolase activity
HRD70_03830	COG1764	response to oxidative stress
HRD70_03850	COG2986	histidine ammonia-lyase
HRD70_03855	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HRD70_03860	COG1609	Transcriptional regulator
HRD70_03900	COG2205	protein histidine kinase activity
HRD70_03900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD70_03955	COG0582	viral genome integration into host DNA
HRD70_03965	COG1609	Transcriptional regulator
HRD70_03965	COG2207	Transcriptional regulator
HRD70_03970	COG4214	carbohydrate transport
HRD70_03980	COG4213	ABC transporter substrate-binding protein
HRD70_03985	COG2115	Belongs to the xylose isomerase family
HRD70_03990	COG1070	Carbohydrate kinase
HRD70_03995	COG3121	Chaperone
HRD70_04000	COG1335	isochorismatase
HRD70_04010	COG3274	enterobacterial common antigen metabolic process
HRD70_04020	COG3276	selenocysteine insertion sequence binding
HRD70_04025	COG1921	L-seryl-tRNASec selenium transferase activity
HRD70_04030	COG3058	Necessary for formate dehydrogenase activity
HRD70_04035	COG2864	formate dehydrogenase
HRD70_04040	COG0437	4 iron, 4 sulfur cluster binding
HRD70_04050	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HRD70_04055	COG3549	Plasmid maintenance system killer
HRD70_04060	COG3093	addiction module antidote protein HigA
HRD70_04065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRD70_04070	COG0840	transmembrane signaling receptor activity
HRD70_04080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD70_04090	COG3722	fumarate hydratase activity
HRD70_04095	COG0246	Mannitol dehydrogenase
HRD70_04100	COG2213	PTS system mannitol-specific
HRD70_04100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD70_04115	COG0751	glycine-tRNA ligase activity
HRD70_04120	COG0752	glycyl-tRNA synthetase alpha subunit
HRD70_04125	COG2818	Glycosylase
HRD70_04130	COG0456	acetyltransferase
HRD70_04160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRD70_04165	COG3668	Plasmid stabilization system
HRD70_04170	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRD70_04175	COG0366	Alpha amylase catalytic
HRD70_04180	COG3977	Valine--pyruvate aminotransferase
HRD70_04185	COG2985	domain, Protein
HRD70_04185	COG0569	domain protein
HRD70_04200	COG5645	(Lipo)protein
HRD70_04205	COG0823	Involved in the tonB-independent uptake of proteins
HRD70_04220	COG2423	ornithine cyclodeaminase activity
HRD70_04225	COG2188	Transcriptional regulator
HRD70_04230	COG2723	6-phospho-beta-galactosidase activity
HRD70_04240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD70_04245	COG1940	carbohydrate kinase activity
HRD70_04255	COG1447	Phosphotransferase system cellobiose-specific component IIA
HRD70_04260	COG0561	phosphatase activity
HRD70_04265	COG0187	DNA topoisomerase II activity
HRD70_04270	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRD70_04275	COG0592	DNA-directed DNA polymerase activity
HRD70_04280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRD70_04285	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRD70_04290	COG0594	ribonuclease P activity
HRD70_04300	COG0706	membrane insertase activity
HRD70_04305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRD70_04310	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRD70_04320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRD70_04325	COG2011	ABC-type metal ion transport system permease component
HRD70_04330	COG0840	transmembrane signaling receptor activity
HRD70_04335	COG0431	NADPH-dependent FMN reductase
HRD70_04340	COG4191	Histidine kinase
HRD70_04345	COG4566	intracellular signal transduction
HRD70_04355	COG2252	PERMEase
HRD70_04360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD70_04365	COG0765	amino acid transport
HRD70_04370	COG0765	amino acid transport
HRD70_04375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD70_04385	COG0704	Plays a role in the regulation of phosphate uptake
HRD70_04395	COG0581	inorganic phosphate transmembrane transporter activity
HRD70_04400	COG0573	inorganic phosphate transmembrane transporter activity
HRD70_04405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRD70_04415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRD70_04420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRD70_04425	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRD70_04435	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRD70_04440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRD70_04445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRD70_04455	COG0356	it plays a direct role in the translocation of protons across the membrane
HRD70_04460	COG3312	ion transport
HRD70_04465	COG0357	Ribosomal RNA small subunit methyltransferase G
HRD70_04470	COG0445	tRNA wobble uridine modification
HRD70_04475	COG0716	FMN binding
HRD70_04480	COG1522	sequence-specific DNA binding
HRD70_04485	COG2502	aspartate--ammonia ligase
HRD70_04495	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HRD70_04500	COG0714	Associated with various cellular activities
HRD70_04505	COG3158	transport of potassium into the cell
HRD70_04510	COG1869	D-ribose catabolic process
HRD70_04520	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD70_04525	COG1879	ABC-type sugar transport system periplasmic component
HRD70_04530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD70_04535	COG1609	Transcriptional regulator
HRD70_04540	COG0477	Major facilitator Superfamily
HRD70_04545	COG2186	Transcriptional regulator
HRD70_04570	COG1763	Mo-molybdopterin cofactor biosynthetic process
HRD70_04580	COG3084	Protein conserved in bacteria
HRD70_04585	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HRD70_04590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRD70_04595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD70_04595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD70_04600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HRD70_04605	COG3078	GTPase activator activity
HRD70_04610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRD70_04620	COG3852	Histidine kinase
HRD70_04635	COG1011	Hydrolase
HRD70_04640	COG1295	ribonuclease BN
HRD70_04645	COG1490	D-aminoacyl-tRNA deacylase activity
HRD70_04650	COG0456	acetyltransferase
HRD70_04655	COG3423	Transcriptional regulator
HRD70_04665	COG2982	Protein involved in outer membrane biogenesis
HRD70_04670	COG2233	PERMEase
HRD70_04675	COG0786	glutamate:sodium symporter activity
HRD70_04680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRD70_04685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD70_04690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD70_04695	COG1758	RNA polymerase activity
HRD70_04705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRD70_04710	COG2860	membrane
HRD70_04720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD70_04725	COG1024	Enoyl-CoA hydratase
HRD70_04730	COG5001	Diguanylate cyclase
HRD70_04745	COG0519	Catalyzes the synthesis of GMP from XMP
HRD70_04765	COG1396	sequence-specific DNA binding
HRD70_04805	COG1561	YicC-like family, N-terminal region
HRD70_04820	COG1309	transcriptional regulator
HRD70_04825	COG0756	dUTP diphosphatase activity
HRD70_04830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HRD70_04835	COG2003	Belongs to the UPF0758 family
HRD70_04840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRD70_04845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRD70_04850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRD70_04865	COG1519	Transferase
HRD70_04870	COG0859	PFAM glycosyl transferase family 9
HRD70_04875	COG0859	PFAM glycosyl transferase family 9
HRD70_04880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD70_04885	COG0156	8-amino-7-oxononanoate synthase activity
HRD70_04890	COG1063	alcohol dehydrogenase
HRD70_04895	COG2861	carbohydrate metabolic process
HRD70_04900	COG4942	peptidase
HRD70_04905	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HRD70_04910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRD70_04915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRD70_04925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRD70_04930	COG1045	serine acetyltransferase
HRD70_04935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HRD70_04940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRD70_04940	COG2169	Transcriptional regulator
HRD70_04945	COG2205	protein histidine kinase activity
HRD70_04950	COG0745	RESPONSE REGULATOR receiver
HRD70_04955	COG3678	ATP-independent chaperone mediated protein folding
HRD70_04960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRD70_04970	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HRD70_04990	COG3152	Membrane
HRD70_05000	COG2814	Major facilitator Superfamily
HRD70_05005	COG1494	fructose-1,6-bisphosphatase
HRD70_05010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD70_05015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRD70_05020	COG3074	FtsZ-dependent cytokinesis
HRD70_05025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRD70_05030	COG1575	Belongs to the MenA family. Type 1 subfamily
HRD70_05035	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HRD70_05040	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HRD70_05045	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRD70_05050	COG1609	Transcriptional regulator
HRD70_05055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRD70_05060	COG0254	rRNA binding
HRD70_05065	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HRD70_05070	COG0626	cystathionine gamma-synthase activity
HRD70_05075	COG0460	homoserine dehydrogenase
HRD70_05075	COG0527	aspartate kinase activity
HRD70_05085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HRD70_05095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRD70_05100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRD70_05105	COG0165	Argininosuccinate lyase
HRD70_05110	COG1629	transport
HRD70_05145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD70_05150	COG0678	peroxiredoxin activity
HRD70_05150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRD70_05160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD70_05165	COG1309	transcriptional regulator
HRD70_05175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRD70_05185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRD70_05225	COG0583	DNA-binding transcription factor activity
HRD70_05230	COG3085	chromosome segregation
HRD70_05250	COG3978	acetolactate synthase activity
HRD70_05255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRD70_05260	COG0129	dihydroxy-acid dehydratase activity
HRD70_05265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRD70_05275	COG0583	DNA-binding transcription factor activity
HRD70_05280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRD70_05330	COG0473	3-isopropylmalate dehydrogenase activity
HRD70_05330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRD70_05335	COG0129	dihydroxy-acid dehydratase activity
HRD70_05340	COG3121	Chaperone
HRD70_05355	COG3121	Chaperone
HRD70_05365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRD70_05375	COG0248	Ppx GppA phosphatase
HRD70_05385	COG3118	belongs to the thioredoxin family
HRD70_05390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HRD70_05395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRD70_05400	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HRD70_05405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HRD70_05410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HRD70_05415	COG1088	dTDP-glucose 4,6-dehydratase activity
HRD70_05420	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HRD70_05425	COG0456	acetyltransferase
HRD70_05430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD70_05435	COG2244	polysaccharide biosynthetic process
HRD70_05440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD70_05480	COG3071	HemY protein
HRD70_05485	COG2959	enzyme of heme biosynthesis
HRD70_05490	COG1587	Uroporphyrinogen-III synthase
HRD70_05495	COG0181	hydroxymethylbilane synthase activity
HRD70_05500	COG3072	Adenylate cyclase
HRD70_05505	COG1965	Belongs to the frataxin family
HRD70_05510	COG5567	small periplasmic lipoprotein
HRD70_05515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRD70_05520	COG3159	Protein conserved in bacteria
HRD70_05525	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HRD70_05530	COG1011	Hydrolase
HRD70_05535	COG0210	DNA helicase
HRD70_05545	COG5441	Belongs to the UPF0261 family
HRD70_05550	COG5564	TIM-barrel signal transduction protein
HRD70_05570	COG2050	protein possibly involved in aromatic compounds catabolism
HRD70_05575	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HRD70_05580	COG0514	ATP-dependent DNA helicase (RecQ)
HRD70_05590	COG1280	lysine exporter protein (LysE YggA)
HRD70_05595	COG2267	carboxylic ester hydrolase activity
HRD70_05600	COG0561	phosphatase activity
HRD70_05605	COG0584	glycerophosphoryl diester phosphodiesterase
HRD70_05610	COG2271	Major facilitator Superfamily
HRD70_05620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRD70_05630	COG0247	lactate metabolic process
HRD70_05640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HRD70_05645	COG0425	Belongs to the sulfur carrier protein TusA family
HRD70_05655	COG3714	YhhN family
HRD70_05670	COG3776	membrane
HRD70_05675	COG0742	ribosomal rna small subunit methyltransferase
HRD70_05680	COG0552	protein localization to endoplasmic reticulum
HRD70_05685	COG2884	Cell division ATP-binding protein ftsE
HRD70_05690	COG2177	Part of the ABC transporter FtsEX involved in
HRD70_05715	COG0683	leucine binding
HRD70_05725	COG4177	L-phenylalanine transmembrane transporter activity
HRD70_05735	COG0410	ABC transporter
HRD70_05770	COG1653	transport
HRD70_05775	COG1175	transmembrane transport
HRD70_05780	COG0395	ABC-type sugar transport system, permease component
HRD70_05785	COG3842	ATPase activity
HRD70_05790	COG0584	glycerophosphoryl diester phosphodiesterase
HRD70_05795	COG0679	Auxin Efflux Carrier
HRD70_05800	COG0697	spore germination
HRD70_05805	COG0583	DNA-binding transcription factor activity
HRD70_05810	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HRD70_05815	COG0412	Dienelactone hydrolase
HRD70_05830	COG1966	Carbon starvation protein
HRD70_05835	COG0586	Pfam SNARE associated Golgi protein
HRD70_05840	COG1322	Protein conserved in bacteria
HRD70_05845	COG2226	methyltransferase
HRD70_05855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRD70_05860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD70_05865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD70_05870	COG0805	protein transport
HRD70_05885	COG0250	Participates in transcription elongation, termination and antitermination
HRD70_05890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HRD70_05900	COG0183	Belongs to the thiolase family
HRD70_05905	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD70_05905	COG1024	Enoyl-CoA hydratase
HRD70_05910	COG0006	proline dipeptidase activity
HRD70_05915	COG1739	Uncharacterized protein family UPF0029
HRD70_05920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRD70_05950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRD70_05955	COG3162	membrane
HRD70_05960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRD70_05965	COG1301	dicarboxylic acid transport
HRD70_06130	COG2391	methyltransferase activity
HRD70_06135	COG0425	Belongs to the sulfur carrier protein TusA family
HRD70_06145	COG1191	sigma factor activity
HRD70_06150	COG3712	iron ion homeostasis
HRD70_06155	COG4771	TonB-dependent receptor
HRD70_06160	COG4178	(ABC) transporter
HRD70_06165	COG0612	Peptidase, M16
HRD70_06170	COG3264	Mechanosensitive ion channel
HRD70_06170	COG1196	nuclear chromosome segregation
HRD70_06175	COG4774	siderophore transport
HRD70_06185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD70_06190	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HRD70_06195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD70_06200	COG4558	Periplasmic binding protein
HRD70_06205	COG3720	iron ion transport
HRD70_06235	COG4774	siderophore transport
HRD70_06245	COG1595	DNA-templated transcription, initiation
HRD70_06305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRD70_06370	COG1192	Involved in chromosome partitioning
HRD70_06430	COG1204	response to ionizing radiation
HRD70_06535	COG2132	Multicopper oxidase
HRD70_06550	COG2205	protein histidine kinase activity
HRD70_06555	COG0745	RESPONSE REGULATOR receiver
HRD70_06560	COG1276	copper resistance
HRD70_06565	COG2372	response to copper ion
HRD70_06570	COG3667	copper resistance
HRD70_06575	COG2132	Multicopper oxidase
HRD70_06590	COG0739	heme binding
HRD70_06620	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD70_06630	COG0745	RESPONSE REGULATOR receiver
HRD70_06660	COG1309	transcriptional regulator
HRD70_06665	COG1929	Belongs to the glycerate kinase type-1 family
HRD70_06670	COG4232	protein-disulfide reductase activity
HRD70_06680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HRD70_06695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRD70_06700	COG0459	protein refolding
HRD70_06715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRD70_06735	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HRD70_06740	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HRD70_06745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRD70_06750	COG1053	succinate dehydrogenase
HRD70_06755	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HRD70_06760	COG3264	Mechanosensitive ion channel
HRD70_06760	COG1511	domain protein
HRD70_06765	COG0688	phosphatidylethanolamine metabolic process
HRD70_06770	COG1162	GTPase activity
HRD70_06775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HRD70_06795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRD70_06800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRD70_06800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRD70_06810	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRD70_06815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HRD70_06820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRD70_06825	COG1923	regulation of RNA biosynthetic process
HRD70_06830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRD70_06835	COG0330	HflC and HflK could
HRD70_06840	COG0330	HflC and HflK could
HRD70_06845	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HRD70_06850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRD70_06855	COG1959	2 iron, 2 sulfur cluster binding
HRD70_06860	COG0557	exoribonuclease II activity
HRD70_06865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD70_06870	COG1960	acyl-CoA dehydrogenase activity
HRD70_06875	COG3650	response to hydrogen peroxide
HRD70_06880	COG1073	alpha beta
HRD70_06890	COG0360	Binds together with S18 to 16S ribosomal RNA
HRD70_06895	COG2965	DNA replication, synthesis of RNA primer
HRD70_06900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRD70_06905	COG0359	binds to the 23S rRNA
HRD70_06915	COG3061	Opacity-associated protein A
HRD70_06920	COG0545	Peptidyl-prolyl cis-trans isomerase
HRD70_06925	COG0737	Belongs to the 5'-nucleotidase family
HRD70_06930	COG1218	3'(2'),5'-bisphosphate nucleotidase
HRD70_06935	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HRD70_06945	COG1253	flavin adenine dinucleotide binding
HRD70_06950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRD70_06960	COG2911	Protein conserved in bacteria
HRD70_06965	COG2105	PFAM AIG2 family protein
HRD70_06970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRD70_06975	COG0840	transmembrane signaling receptor activity
HRD70_06980	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HRD70_06985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRD70_07000	COG1438	arginine binding
HRD70_07005	COG0039	L-malate dehydrogenase activity
HRD70_07010	COG3423	Transcriptional regulator
HRD70_07020	COG0142	geranyltranstransferase activity
HRD70_07035	COG0697	spore germination
HRD70_07040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRD70_07045	COG0642	Histidine kinase
HRD70_07050	COG0745	RESPONSE REGULATOR receiver
HRD70_07055	COG2027	D-alanyl-D-alanine carboxypeptidase
HRD70_07065	COG1534	Rna-binding protein
HRD70_07070	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HRD70_07080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRD70_07090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRD70_07105	COG0779	Required for maturation of 30S ribosomal subunits
HRD70_07110	COG0195	Participates in both transcription termination and antitermination
HRD70_07115	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRD70_07120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRD70_07125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRD70_07135	COG1185	polyribonucleotide nucleotidyltransferase activity
HRD70_07150	COG0513	Belongs to the DEAD box helicase family
HRD70_07155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD70_07160	COG0826	peptidase U32
HRD70_07165	COG0826	peptidase U32
HRD70_07170	COG3154	lipid carrier protein
HRD70_07175	COG3153	acetyltransferase
HRD70_07180	COG2827	Endonuclease containing a URI domain
HRD70_07185	COG0531	amino acid
HRD70_07190	COG1982	Orn Lys Arg decarboxylase major
HRD70_07210	COG1653	transport
HRD70_07215	COG1175	transmembrane transport
HRD70_07220	COG0395	ABC-type sugar transport system, permease component
HRD70_07225	COG3842	ATPase activity
HRD70_07235	COG3787	Belongs to the UPF0306 family
HRD70_07240	COG0702	epimerase
HRD70_07245	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HRD70_07250	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HRD70_07255	COG3454	Phosphonate metabolism
HRD70_07260	COG4778	phosphonate C-P lyase system protein PhnL
HRD70_07265	COG4107	phosphonate C-P lyase system protein PhnK
HRD70_07270	COG3627	carbon phosphorus lyase activity
HRD70_07275	COG3626	phosphonate metabolism
HRD70_07280	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HRD70_07285	COG3624	Phosphonate C-P lyase system protein PhnG
HRD70_07290	COG2188	Transcriptional regulator
HRD70_07310	COG4608	Belongs to the ABC transporter superfamily
HRD70_07315	COG0444	Belongs to the ABC transporter superfamily
HRD70_07325	COG0601	transmembrane transport
HRD70_07335	COG2731	YhcH YjgK YiaL family protein
HRD70_07345	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HRD70_07360	COG2927	DNA polymerase III (CHI subunit)
HRD70_07365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRD70_07370	COG0795	lipopolysaccharide-transporting ATPase activity
HRD70_07375	COG0795	lipopolysaccharide-transporting ATPase activity
HRD70_07385	COG0582	viral genome integration into host DNA
HRD70_07400	COG1002	Type II restriction enzyme, methylase subunits
HRD70_07405	COG1061	Type III restriction enzyme res subunit
HRD70_07410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRD70_07505	COG0583	DNA-binding transcription factor activity
HRD70_07515	COG0454	-acetyltransferase
HRD70_07530	COG1309	transcriptional regulator
HRD70_07535	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRD70_07550	COG0583	DNA-binding transcription factor activity
HRD70_07575	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HRD70_07580	COG1830	Aldolase
HRD70_07585	COG1879	ABC-type sugar transport system periplasmic component
HRD70_07590	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD70_07595	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD70_07600	COG1129	ABC transporter
HRD70_07605	COG2390	Transcriptional regulator
HRD70_07610	COG1070	Carbohydrate kinase
HRD70_07615	COG0859	PFAM glycosyl transferase family 9
HRD70_07630	COG2235	arginine
HRD70_07640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD70_07645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD70_07655	COG2376	Dihydroxyacetone kinase
HRD70_07660	COG1461	Dihydroxyacetone kinase
HRD70_07675	COG2192	nodulation
HRD70_07700	COG3284	Transcriptional regulator
HRD70_07710	COG4772	TonB-dependent receptor
HRD70_07715	COG3706	GGDEF domain
HRD70_07740	COG0667	Aldo Keto reductase
HRD70_07745	COG2813	Specifically methylates the guanine in position
HRD70_07760	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HRD70_07765	COG0456	acetyltransferase
HRD70_07770	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HRD70_07775	COG2823	Periplasmic or secreted lipoprotein
HRD70_07785	COG4667	esterase of the alpha-beta hydrolase superfamily
HRD70_07790	COG0084	hydrolase, TatD family'
HRD70_07795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD70_07805	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HRD70_07810	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HRD70_07820	COG3550	peptidyl-serine autophosphorylation
HRD70_07825	COG3726	membrane protein affecting hemolysin expression
HRD70_07830	COG0560	Phosphoserine phosphatase
HRD70_07855	COG0604	alcohol dehydrogenase
HRD70_07865	COG0488	(ABC) transporter
HRD70_07870	COG2885	chlorophyll binding
HRD70_07875	COG2199	diguanylate cyclase activity
HRD70_07885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HRD70_07890	COG0741	lytic transglycosylase activity
HRD70_07895	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HRD70_07900	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HRD70_07910	COG3708	Transcriptional regulator
HRD70_07910	COG2207	Transcriptional regulator
HRD70_07915	COG3045	CreA protein
HRD70_07920	COG0745	RESPONSE REGULATOR receiver
HRD70_07935	COG0083	homoserine kinase activity
HRD70_07945	COG3022	response to hydroperoxide
HRD70_07950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRD70_07955	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRD70_07970	COG1584	GPR1 FUN34 yaaH family protein
HRD70_07980	COG0484	heat shock protein binding
HRD70_07985	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRD70_07990	COG0583	DNA-binding transcription factor activity
HRD70_08010	COG0196	riboflavin kinase activity
HRD70_08015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRD70_08020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRD70_08025	COG1047	Peptidyl-prolyl cis-trans
HRD70_08030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRD70_08035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRD70_08045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRD70_08050	COG1280	lysine exporter protein (LysE YggA)
HRD70_08055	COG2966	Psort location CytoplasmicMembrane, score
HRD70_08065	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HRD70_08070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRD70_08075	COG2967	ApaG domain
HRD70_08085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HRD70_08095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD70_08105	COG0564	pseudouridine synthase activity
HRD70_08110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRD70_08115	COG0417	DNA replication proofreading
HRD70_08120	COG0586	Pfam SNARE associated Golgi protein
HRD70_08130	COG1178	ABC-type Fe3 transport system permease component
HRD70_08135	COG4143	(ABC) transporter
HRD70_08145	COG4533	DNA binding
HRD70_08150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRD70_08155	COG1882	Formate acetyltransferase
HRD70_08160	COG2814	Major facilitator Superfamily
HRD70_08165	COG3033	Beta-eliminating lyase
HRD70_08180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRD70_08185	COG0473	3-isopropylmalate dehydrogenase activity
HRD70_08190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRD70_08205	COG1022	Amp-dependent synthetase and ligase
HRD70_08210	COG0028	Belongs to the TPP enzyme family
HRD70_08230	COG2001	Belongs to the MraZ family
HRD70_08235	COG0275	rRNA processing
HRD70_08240	COG3116	cell division
HRD70_08245	COG0768	penicillin binding
HRD70_08250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRD70_08255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRD70_08260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRD70_08270	COG0772	Belongs to the SEDS family
HRD70_08275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRD70_08280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRD70_08290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HRD70_08295	COG0849	cell division
HRD70_08300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HRD70_08320	COG0653	protein targeting
HRD70_08325	COG0494	nUDIX hydrolase
HRD70_08330	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HRD70_08345	COG0516	GMP reductase activity
HRD70_08350	COG1459	type II secretion system
HRD70_08355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRD70_08360	COG4969	Belongs to the N-Me-Phe pilin family
HRD70_08375	COG3725	Membrane protein required for beta-lactamase induction
HRD70_08380	COG1113	amino acid transport
HRD70_08385	COG2186	Transcriptional regulator
HRD70_08390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HRD70_08395	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD70_08400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD70_08420	COG1049	propionate catabolic process, 2-methylcitrate cycle
HRD70_08425	COG3112	Uncharacterised protein family (UPF0231)
HRD70_08430	COG0697	spore germination
HRD70_08445	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HRD70_08450	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HRD70_08460	COG2132	Multicopper oxidase
HRD70_08470	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HRD70_08475	COG0288	reversible hydration of carbon dioxide
HRD70_08480	COG1131	(ABC) transporter
HRD70_08485	COG0842	Transport permease protein
HRD70_08490	COG0726	polysaccharide deacetylase
HRD70_08495	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HRD70_08500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRD70_08505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRD70_08510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRD70_08515	COG0617	tRNA 3'-terminal CCA addition
HRD70_08530	COG1489	DNA binding
HRD70_08535	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HRD70_08540	COG1643	Atp-dependent helicase
HRD70_08545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD70_08550	COG1120	ATPase activity
HRD70_08555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRD70_08560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD70_08570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRD70_08580	COG0316	Belongs to the HesB IscA family
HRD70_08590	COG2860	membrane
HRD70_08600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRD70_08605	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRD70_08610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD70_08615	COG4999	Histidine kinase
HRD70_08615	COG2205	protein histidine kinase activity
HRD70_08615	COG3437	response regulator, receiver
HRD70_08615	COG3850	Histidine kinase
HRD70_08625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD70_08630	COG3956	TIGRFAM MazG family protein
HRD70_08635	COG0504	CTP synthase activity
HRD70_08640	COG0148	phosphopyruvate hydratase activity
HRD70_08665	COG0602	queuosine metabolic process
HRD70_08670	COG0720	synthase
HRD70_08675	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HRD70_08680	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD70_08685	COG0175	sulfate reduction
HRD70_08690	COG2234	aminopeptidase activity
HRD70_08695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRD70_08695	COG1648	precorrin-2 dehydrogenase activity
HRD70_08700	COG0175	sulfate reduction
HRD70_08705	COG2895	sulfate adenylyltransferase (ATP) activity
HRD70_08710	COG0529	Catalyzes the synthesis of activated sulfate
HRD70_08725	COG0765	amino acid transport
HRD70_08735	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HRD70_08745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRD70_08750	COG0585	pseudouridine synthase activity
HRD70_08755	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRD70_08760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRD70_08765	COG4942	peptidase
HRD70_08765	COG1388	LysM domain
HRD70_08770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRD70_08775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HRD70_08800	COG3188	usher protein
HRD70_08805	COG3121	Chaperone
HRD70_08820	COG3539	Fimbrial protein
HRD70_08825	COG3539	Fimbrial protein
HRD70_08855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD70_08860	COG0577	efflux transmembrane transporter activity
HRD70_08860	COG1136	(ABC) transporter
HRD70_08865	COG1538	Outer membrane efflux protein
HRD70_08885	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_08890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD70_08900	COG1858	cytochrome C peroxidase
HRD70_08915	COG3048	D-serine ammonia-lyase activity
HRD70_08920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD70_08925	COG0765	amino acid transport
HRD70_08930	COG0765	amino acid transport
HRD70_08935	COG4598	ABC transporter
HRD70_08940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD70_08945	COG3665	Urea carboxylase-associated protein
HRD70_08960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRD70_08965	COG0640	Transcriptional regulator
HRD70_09025	COG0410	ABC transporter
HRD70_09030	COG1137	ATPase activity
HRD70_09035	COG4177	L-phenylalanine transmembrane transporter activity
HRD70_09050	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD70_09050	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD70_09055	COG1349	DNA-binding transcription factor activity
HRD70_09065	COG1070	Carbohydrate kinase
HRD70_09075	COG0738	Major facilitator superfamily
HRD70_09080	COG0235	Class ii aldolase
HRD70_09085	COG1454	alcohol dehydrogenase
HRD70_09090	COG0243	molybdopterin cofactor binding
HRD70_09095	COG0437	4 iron, 4 sulfur cluster binding
HRD70_09100	COG3302	dmso reductase anchor subunit
HRD70_09105	COG3381	protein complex oligomerization
HRD70_09120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRD70_09125	COG2137	regulation of response to DNA damage stimulus
HRD70_09130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRD70_09135	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HRD70_09160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD70_09165	COG1238	metal cluster binding
HRD70_09170	COG2918	glutathione biosynthetic process
HRD70_09175	COG1854	S-ribosylhomocysteine lyase activity
HRD70_09180	COG4536	flavin adenine dinucleotide binding
HRD70_09185	COG4137	Cytochrome C assembly protein
HRD70_09190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HRD70_09200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRD70_09205	COG0336	Belongs to the RNA methyltransferase TrmD family
HRD70_09210	COG0335	large ribosomal subunit rRNA binding
HRD70_09215	COG3137	Salt-induced outer membrane protein
HRD70_09220	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HRD70_09225	COG3279	Response regulator of the LytR AlgR family
HRD70_09230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRD70_09235	COG1605	Chorismate mutase
HRD70_09235	COG0287	Prephenate dehydrogenase
HRD70_09240	COG0077	Prephenate dehydratase
HRD70_09240	COG1605	Chorismate mutase
HRD70_09245	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRD70_09250	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD70_09255	COG0564	pseudouridine synthase activity
HRD70_09265	COG0542	response to heat
HRD70_09295	COG0656	L-ascorbic acid biosynthetic process
HRD70_09300	COG0583	DNA-binding transcription factor activity
HRD70_09305	COG2814	Major facilitator Superfamily
HRD70_09310	COG3021	interspecies interaction between organisms
HRD70_09315	COG0741	lytic transglycosylase activity
HRD70_09315	COG1388	LysM domain
HRD70_09320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD70_09325	COG2226	methyltransferase
HRD70_09330	COG0328	RNA-DNA hybrid ribonuclease activity
HRD70_09335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD70_09345	COG1953	Uracil, thiamine, allantoin
HRD70_09365	COG2113	Glycine betaine
HRD70_09370	COG4176	ABC-type proline glycine betaine transport system permease component
HRD70_09380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD70_09390	COG1780	Probably involved in ribonucleotide reductase function
HRD70_09395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRD70_09400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD70_09410	COG4575	ribosome binding
HRD70_09440	COG1278	Cold shock
HRD70_09470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD70_09480	COG1124	(ABC) transporter
HRD70_09485	COG0831	urea catabolic process
HRD70_09490	COG0832	Belongs to the urease beta subunit family
HRD70_09495	COG0804	urea catabolic process
HRD70_09500	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HRD70_09510	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRD70_09515	COG0829	nickel cation binding
HRD70_09520	COG4413	Urea transporter
HRD70_09525	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HRD70_09535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRD70_09550	COG0667	Aldo Keto reductase
HRD70_09555	COG2133	pyrroloquinoline quinone binding
HRD70_09560	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD70_09565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD70_09570	COG2723	6-phospho-beta-galactosidase activity
HRD70_09575	COG1447	Phosphotransferase system cellobiose-specific component IIA
HRD70_09580	COG1917	Cupin 2, conserved barrel domain protein
HRD70_09580	COG2169	Transcriptional regulator
HRD70_09585	COG3394	polysaccharide catabolic process
HRD70_09595	COG0583	DNA-binding transcription factor activity
HRD70_09605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRD70_09615	COG1136	(ABC) transporter
HRD70_09615	COG0577	efflux transmembrane transporter activity
HRD70_09660	COG0583	DNA-binding transcription factor activity
HRD70_09665	COG0456	acetyltransferase
HRD70_09685	COG2003	Belongs to the UPF0758 family
HRD70_09720	COG4983	Phage plasmid primase, P4 family domain protein
HRD70_09725	COG3311	Transcriptional regulator
HRD70_09730	COG2963	transposase activity
HRD70_09755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRD70_09755	COG0784	Response regulator, receiver
HRD70_09760	COG0582	viral genome integration into host DNA
HRD70_09770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRD70_09775	COG2867	negative regulation of translational initiation
HRD70_09785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD70_09790	COG0497	DNA recombination
HRD70_09795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRD70_09800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRD70_09805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRD70_09810	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HRD70_09830	COG0513	Belongs to the DEAD box helicase family
HRD70_09835	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HRD70_09840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HRD70_09850	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HRD70_09860	COG3086	response to oxidative stress
HRD70_09870	COG0481	GTPase activity
HRD70_09885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRD70_09890	COG1381	Involved in DNA repair and RecF pathway recombination
HRD70_09895	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HRD70_09900	COG0736	holo-[acyl-carrier-protein] synthase activity
HRD70_09905	COG2610	gluconate transmembrane transporter activity
HRD70_09910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD70_09915	COG1737	Transcriptional regulator
HRD70_09925	COG0560	Phosphoserine phosphatase
HRD70_09940	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HRD70_09955	COG2205	protein histidine kinase activity
HRD70_09960	COG3170	Tfp pilus assembly protein FimV
HRD70_09965	COG2204	response regulator
HRD70_09970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD70_09970	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRD70_09975	COG0347	Belongs to the P(II) protein family
HRD70_09985	COG2188	Transcriptional regulator
HRD70_09990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD70_09990	COG1017	nitric oxide dioxygenase activity
HRD70_09995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRD70_10000	COG2814	Major facilitator Superfamily
HRD70_10005	COG3711	transcriptional antiterminator
HRD70_10010	COG3683	transport system, periplasmic component
HRD70_10015	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HRD70_10020	COG0483	inositol monophosphate 1-phosphatase activity
HRD70_10025	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HRD70_10030	COG1959	2 iron, 2 sulfur cluster binding
HRD70_10040	COG0822	iron-sulfur transferase activity
HRD70_10050	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HRD70_10055	COG0443	Heat shock 70 kDa protein
HRD70_10060	COG0633	Ferredoxin
HRD70_10065	COG2975	iron-sulfur cluster assembly
HRD70_10080	COG3468	outer membrane autotransporter barrel domain protein
HRD70_10085	COG2373	Large extracellular alpha-helical protein
HRD70_10090	COG4953	penicillin-binding protein 1C
HRD70_10105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRD70_10115	COG1426	Protein conserved in bacteria
HRD70_10120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRD70_10125	COG0124	histidyl-tRNA synthetase
HRD70_10130	COG2976	Protein conserved in bacteria
HRD70_10135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD70_10140	COG1160	GTP binding
HRD70_10150	COG1645	bacterial-type flagellum-dependent swarming motility
HRD70_10155	COG1570	exodeoxyribonuclease VII activity
HRD70_10160	COG0517	IMP dehydrogenase activity
HRD70_10160	COG0516	GMP reductase activity
HRD70_10165	COG0519	Catalyzes the synthesis of GMP from XMP
HRD70_10165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRD70_10200	COG0351	phosphomethylpyrimidine kinase
HRD70_10220	COG1349	DNA-binding transcription factor activity
HRD70_10225	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD70_10230	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_10245	COG3730	PTS system glucitol sorbitol-specific
HRD70_10250	COG1597	lipid kinase activity
HRD70_10260	COG3422	double-strand break repair
HRD70_10265	COG0745	RESPONSE REGULATOR receiver
HRD70_10270	COG2205	protein histidine kinase activity
HRD70_10275	COG0477	Major facilitator Superfamily
HRD70_10280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD70_10290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD70_10295	COG0443	Heat shock 70 kDa protein
HRD70_10300	COG5002	protein histidine kinase activity
HRD70_10300	COG3447	MASE1 domain protein
HRD70_10300	COG5001	Diguanylate cyclase
HRD70_10305	COG2239	Acts as a magnesium transporter
HRD70_10320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRD70_10325	COG0573	inorganic phosphate transmembrane transporter activity
HRD70_10330	COG0581	inorganic phosphate transmembrane transporter activity
HRD70_10345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD70_10350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRD70_10355	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRD70_10360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRD70_10365	COG2233	PERMEase
HRD70_10370	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRD70_10375	COG1393	Belongs to the ArsC family
HRD70_10380	COG4783	chaperone-mediated protein folding
HRD70_10385	COG0628	permease
HRD70_10390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRD70_10395	COG2716	regulation of RNA biosynthetic process
HRD70_10400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD70_10405	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HRD70_10410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRD70_10415	COG2321	neutral zinc metallopeptidase
HRD70_10420	COG2707	UPF0756 membrane protein
HRD70_10425	COG1444	tRNA N-acetyltransferase activity
HRD70_10430	COG0400	carboxylic ester hydrolase activity
HRD70_10440	COG1876	peptidase activity
HRD70_10445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD70_10450	COG1393	Belongs to the ArsC family
HRD70_10630	COG1175	transmembrane transport
HRD70_10635	COG3842	ATPase activity
HRD70_10645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD70_10655	COG2197	response regulator
HRD70_10665	COG3062	negative regulation of establishment of protein localization
HRD70_10670	COG0243	molybdopterin cofactor binding
HRD70_10675	COG3043	anaerobic respiration
HRD70_10680	COG3005	denitrification pathway
HRD70_10685	COG0494	nUDIX hydrolase
HRD70_10695	COG1671	Belongs to the UPF0178 family
HRD70_10700	COG0408	coproporphyrinogen oxidase activity
HRD70_10705	COG0456	acetyltransferase
HRD70_10715	COG2814	Major facilitator Superfamily
HRD70_10725	COG1129	ABC transporter
HRD70_10730	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD70_10750	COG2897	thiosulfate sulfurtransferase activity
HRD70_10755	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_10765	COG3111	PFAM Bacterial OB fold (BOF) protein
HRD70_10775	COG2837	iron assimilation
HRD70_10780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD70_10795	COG2731	YhcH YjgK YiaL family protein
HRD70_10800	COG1737	Transcriptional regulator
HRD70_10810	COG4150	thiosulfate binding
HRD70_10815	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HRD70_10820	COG4208	sulfate ABC transporter
HRD70_10835	COG4886	Leucine-rich repeat (LRR) protein
HRD70_10850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD70_10855	COG0745	RESPONSE REGULATOR receiver
HRD70_10860	COG2205	protein histidine kinase activity
HRD70_10870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD70_10875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD70_10885	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HRD70_10895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRD70_10900	COG3530	Putative quorum-sensing-regulated virulence factor
HRD70_10925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRD70_10970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD70_10975	COG1914	H( )-stimulated, divalent metal cation uptake system
HRD70_10985	COG0667	Aldo Keto reductase
HRD70_10990	COG3961	Belongs to the TPP enzyme family
HRD70_11005	COG0837	glucose binding
HRD70_11010	COG2223	nitrite transmembrane transporter activity
HRD70_11015	COG3279	Response regulator of the LytR AlgR family
HRD70_11020	COG3275	phosphorelay sensor kinase activity
HRD70_11035	COG0436	Aminotransferase
HRD70_11040	COG3038	cytochrome b561
HRD70_11055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD70_11085	COG3302	dmso reductase anchor subunit
HRD70_11090	COG0437	4 iron, 4 sulfur cluster binding
HRD70_11095	COG0243	molybdopterin cofactor binding
HRD70_11105	COG1280	lysine exporter protein (LysE YggA)
HRD70_11125	COG2951	lytic endotransglycosylase activity
HRD70_11130	COG0531	amino acid
HRD70_11150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRD70_11155	COG1127	ABC transporter
HRD70_11170	COG3038	cytochrome b561
HRD70_11175	COG2353	YceI-like domain
HRD70_11180	COG1609	Transcriptional regulator
HRD70_11185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD70_11185	COG1263	PTS System
HRD70_11190	COG2723	6-phospho-beta-galactosidase activity
HRD70_11200	COG1695	Transcriptional regulator
HRD70_11215	COG2824	Alkylphosphonate utilization operon protein PhnA
HRD70_11220	COG1464	Belongs to the NlpA lipoprotein family
HRD70_11225	COG2011	ABC-type metal ion transport system permease component
HRD70_11230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRD70_11240	COG2116	formate transmembrane transporter activity
HRD70_11250	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD70_11255	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD70_11260	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD70_11265	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HRD70_11270	COG1138	Cytochrome C-type biogenesis protein
HRD70_11275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD70_11285	COG3088	subunit of a heme lyase
HRD70_11285	COG4235	cytochrome complex assembly
HRD70_11310	COG3691	Protein conserved in bacteria
HRD70_11315	COG0183	Belongs to the thiolase family
HRD70_11320	COG1024	Enoyl-CoA hydratase
HRD70_11320	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD70_11325	COG2062	phosphohistidine phosphatase, SixA
HRD70_11330	COG2840	Smr protein MutS2
HRD70_11335	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD70_11340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRD70_11345	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HRD70_11350	COG0730	response to heat
HRD70_11355	COG3101	peptidyl-lysine hydroxylation
HRD70_11365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD70_11365	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HRD70_11370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD70_11380	COG1794	racemase activity, acting on amino acids and derivatives
HRD70_11390	COG1447	Phosphotransferase system cellobiose-specific component IIA
HRD70_11395	COG2723	6-phospho-beta-galactosidase activity
HRD70_11400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD70_11410	COG1609	Transcriptional regulator
HRD70_11420	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HRD70_11430	COG4232	protein-disulfide reductase activity
HRD70_11440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD70_11445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD70_11455	COG0697	spore germination
HRD70_11465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD70_11470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRD70_11480	COG0586	Pfam SNARE associated Golgi protein
HRD70_11485	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HRD70_11490	COG0285	dihydrofolate synthase activity
HRD70_11495	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HRD70_11500	COG1286	toxin biosynthetic process
HRD70_11505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HRD70_11515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD70_11520	COG4215	(ABC) transporter
HRD70_11525	COG4160	amino acid transport
HRD70_11535	COG1090	epimerase
HRD70_11545	COG0622	Phosphoesterase
HRD70_11550	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HRD70_11555	COG3037	sugar-specific permease SgaT UlaA
HRD70_11565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD70_11570	COG1609	Transcriptional regulator
HRD70_11575	COG0280	phosphate acetyltransferase
HRD70_11575	COG0857	belongs to the CobB CobQ family
HRD70_11585	COG3092	negative regulation of chromosome organization
HRD70_11590	COG3013	Belongs to the UPF0304 family
HRD70_11595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD70_11600	COG0471	metal ion transport
HRD70_11600	COG0490	domain, Protein
HRD70_11605	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HRD70_11615	COG0436	Aminotransferase
HRD70_11625	COG0583	DNA-binding transcription factor activity
HRD70_11630	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD70_11635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD70_11640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD70_11640	COG0649	NAD binding
HRD70_11655	COG1034	ATP synthesis coupled electron transport
HRD70_11660	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRD70_11665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD70_11670	COG0839	Belongs to the complex I subunit 6 family
HRD70_11675	COG0713	ATP synthesis coupled electron transport
HRD70_11680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRD70_11685	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD70_11690	COG1007	ATP synthesis coupled electron transport
HRD70_11720	COG3265	gluconokinase activity
HRD70_11725	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_11730	COG1609	Transcriptional regulator
HRD70_11735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRD70_11745	COG4702	Belongs to the UPF0303 family
HRD70_11750	COG0129	dihydroxy-acid dehydratase activity
HRD70_11755	COG4575	ribosome binding
HRD70_11760	COG1169	isochorismate synthase
HRD70_11765	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HRD70_11770	COG0596	Alpha beta hydrolase
HRD70_11775	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HRD70_11780	COG1441	menaquinone biosynthetic process
HRD70_11800	COG0814	amino acid
HRD70_11810	COG4574	serine-type endopeptidase inhibitor activity
HRD70_11815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD70_11825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD70_11830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD70_11840	COG0784	Response regulator, receiver
HRD70_11840	COG2205	protein histidine kinase activity
HRD70_11850	COG0642	Histidine kinase
HRD70_11850	COG2198	Histidine kinase
HRD70_11855	COG2223	nitrite transmembrane transporter activity
HRD70_11865	COG1063	alcohol dehydrogenase
HRD70_11870	COG0789	Transcriptional regulator
HRD70_11875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HRD70_11890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HRD70_11945	COG3772	lysozyme
HRD70_11970	COG4386	tail sheath protein
HRD70_12010	COG3299	homolog of phage Mu protein gp47
HRD70_12025	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HRD70_12035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD70_12035	COG2190	(PTS) system
HRD70_12035	COG1263	PTS System
HRD70_12040	COG2723	6-phospho-beta-galactosidase activity
HRD70_12075	COG3082	Protein of unknown function (DUF1414)
HRD70_12080	COG3081	Nucleoid-associated protein
HRD70_12090	COG1061	Type III restriction enzyme res subunit
HRD70_12095	COG1187	pseudouridine synthase activity
HRD70_12100	COG2814	Major facilitator Superfamily
HRD70_12110	COG4172	Belongs to the ABC transporter superfamily
HRD70_12115	COG4239	(ABC) transporter, permease
HRD70_12120	COG4174	ABC transporter (Permease)
HRD70_12125	COG4166	transmembrane transport
HRD70_12130	COG2200	EAL domain
HRD70_12135	COG0791	NLP P60 protein
HRD70_12140	COG0671	phosphoesterase, PA-phosphatase related
HRD70_12145	COG0523	cobalamin synthesis protein
HRD70_12150	COG2186	Transcriptional regulator
HRD70_12155	COG0246	Mannitol dehydrogenase
HRD70_12165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRD70_12180	COG0243	molybdopterin cofactor binding
HRD70_12185	COG3005	denitrification pathway
HRD70_12190	COG0494	nUDIX hydrolase
HRD70_12200	COG1105	Belongs to the carbohydrate kinase PfkB family
HRD70_12205	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HRD70_12205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRD70_12205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRD70_12210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HRD70_12215	COG2855	membrane
HRD70_12225	COG0583	DNA-binding transcription factor activity
HRD70_12230	COG0833	amino acid
HRD70_12235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD70_12245	COG4771	TonB-dependent receptor
HRD70_12250	COG0625	glutathione transferase activity
HRD70_12275	COG2011	ABC-type metal ion transport system permease component
HRD70_12280	COG0626	cystathionine gamma-synthase activity
HRD70_12290	COG1686	Belongs to the peptidase S11 family
HRD70_12295	COG1760	l-serine dehydratase
HRD70_12300	COG0814	amino acid
HRD70_12305	COG1349	DNA-binding transcription factor activity
HRD70_12310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRD70_12315	COG0671	phosphoesterase, PA-phosphatase related
HRD70_12325	COG2985	domain, Protein
HRD70_12325	COG0569	domain protein
HRD70_12345	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HRD70_12350	COG3842	ATPase activity
HRD70_12355	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRD70_12360	COG1177	transmembrane transport
HRD70_12370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRD70_12375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD70_12380	COG4160	amino acid transport
HRD70_12385	COG4215	(ABC) transporter
HRD70_12390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD70_12395	COG1126	abc transporter atp-binding protein
HRD70_12410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD70_12415	COG0702	epimerase
HRD70_12420	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HRD70_12430	COG0028	Belongs to the TPP enzyme family
HRD70_12435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD70_12440	COG1151	hydroxylamine reductase activity
HRD70_12445	COG2431	L-lysine efflux transmembrane transporter activity
HRD70_12450	COG3593	DNA synthesis involved in DNA repair
HRD70_12455	COG2990	Protein conserved in bacteria
HRD70_12460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD70_12470	COG1278	Cold shock
HRD70_12475	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRD70_12480	COG0542	response to heat
HRD70_12485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRD70_12490	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HRD70_12495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HRD70_12505	COG0492	ferredoxin-NADP+ reductase activity
HRD70_12515	COG3107	peptidoglycan biosynthetic process
HRD70_12515	COG1674	ftsk spoiiie
HRD70_12520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HRD70_12525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRD70_12530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRD70_12535	COG2814	Major facilitator Superfamily
HRD70_12540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRD70_12545	COG1882	Formate acetyltransferase
HRD70_12550	COG2116	formate transmembrane transporter activity
HRD70_12555	COG1944	ATP diphosphatase activity
HRD70_12560	COG0252	asparaginase activity
HRD70_12565	COG2323	membrane
HRD70_12570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HRD70_12575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRD70_12580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HRD70_12585	COG0539	negative regulation of cytoplasmic translation
HRD70_12595	COG2333	competence protein COMEC
HRD70_12595	COG0658	competence protein
HRD70_12605	COG1663	tetraacyldisaccharide 4'-kinase activity
HRD70_12610	COG5383	Protein conserved in bacteria
HRD70_12615	COG1278	Cold shock
HRD70_12620	COG2835	tetraacyldisaccharide 4'-kinase activity
HRD70_12625	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HRD70_12630	COG3173	Aminoglycoside phosphotransferase
HRD70_12635	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HRD70_12640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD70_12645	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HRD70_12655	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HRD70_12660	COG2989	Protein conserved in bacteria
HRD70_12665	COG3108	Peptidase M15
HRD70_12670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD70_12675	COG2200	EAL domain
HRD70_12680	COG1448	Aminotransferase
HRD70_12690	COG0017	Asparaginyl-tRNA synthetase
HRD70_12695	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HRD70_12700	COG0308	aminopeptidase N
HRD70_12705	COG0167	dihydroorotate dehydrogenase activity
HRD70_12715	COG3217	Mosc domain protein beta barrel domain protein
HRD70_12715	COG0633	Ferredoxin
HRD70_12720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRD70_12720	COG0116	Belongs to the methyltransferase superfamily
HRD70_12725	COG0488	(ABC) transporter
HRD70_12730	COG2995	paraquat-inducible protein a
HRD70_12735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRD70_12735	COG3008	intermembrane lipid transfer
HRD70_12740	COG3009	Protein conserved in bacteria
HRD70_12745	COG3130	regulation of translation
HRD70_12750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD70_12760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRD70_12765	COG1067	ATP-dependent peptidase activity
HRD70_12770	COG3120	sequence-specific DNA binding
HRD70_12780	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
HRD70_12785	COG3070	regulator of competence-specific genes
HRD70_12790	COG1289	transmembrane transporter activity
HRD70_12795	COG3304	Inner membrane component domain
HRD70_12800	COG0210	DNA helicase
HRD70_12805	COG1803	Methylglyoxal synthase
HRD70_12815	COG1832	CoA-binding protein
HRD70_12820	COG3785	DNA binding
HRD70_12825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRD70_12835	COG1254	Belongs to the acylphosphatase family
HRD70_12840	COG2920	part of a sulfur-relay system
HRD70_12870	COG2003	Belongs to the UPF0758 family
HRD70_12930	COG3547	Transposase (IS116 IS110 IS902 family)
HRD70_12975	COG0640	Transcriptional regulator
HRD70_13025	COG4983	Phage plasmid primase, P4 family domain protein
HRD70_13030	COG3311	Transcriptional regulator
HRD70_13060	COG0732	type I restriction modification DNA specificity domain
HRD70_13075	COG0582	viral genome integration into host DNA
HRD70_13080	COG1518	maintenance of DNA repeat elements
HRD70_13085	COG1203	CRISPR-associated helicase, Cas3
HRD70_13115	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HRD70_13120	COG0437	4 iron, 4 sulfur cluster binding
HRD70_13125	COG3301	Polysulphide reductase, NrfD
HRD70_13130	COG1138	Cytochrome C-type biogenesis protein
HRD70_13135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD70_13140	COG3088	subunit of a heme lyase
HRD70_13145	COG4235	cytochrome complex assembly
HRD70_13155	COG3263	regulation of cellular component size
HRD70_13170	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HRD70_13175	COG2943	transferase activity, transferring hexosyl groups
HRD70_13180	COG5645	(Lipo)protein
HRD70_13195	COG1012	belongs to the aldehyde dehydrogenase family
HRD70_13200	COG0583	DNA-binding transcription factor activity
HRD70_13205	COG3104	oligopeptide transport
HRD70_13210	COG2814	Major facilitator Superfamily
HRD70_13215	COG2259	Doxx family
HRD70_13220	COG1560	Kdo2-lipid A biosynthetic process
HRD70_13260	COG0628	permease
HRD70_13290	COG0418	dihydroorotase activity
HRD70_13295	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HRD70_13300	COG1530	ribonuclease E activity
HRD70_13300	COG1530	ribonuclease E activity
HRD70_13305	COG0564	pseudouridine synthase activity
HRD70_13315	COG1399	metal-binding, possibly nucleic acid-binding protein
HRD70_13320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRD70_13325	COG0416	fatty acid biosynthetic process
HRD70_13340	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_13350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD70_13355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRD70_13360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRD70_13365	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRD70_13370	COG0470	DNA polymerase III
HRD70_13375	COG0084	hydrolase, TatD family'
HRD70_13380	COG1263	PTS System
HRD70_13380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD70_13415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRD70_13420	COG0537	adenosine 5'-monophosphoramidase activity
HRD70_13425	COG5633	Lipoprotein
HRD70_13430	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HRD70_13445	COG3150	esterase
HRD70_13450	COG1252	NADH dehydrogenase
HRD70_13465	COG3134	Outer membrane lipoprotein
HRD70_13470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HRD70_13475	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRD70_13485	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRD70_13490	COG1940	carbohydrate kinase activity
HRD70_13505	COG2850	peptidyl-arginine hydroxylation
HRD70_13515	COG0745	RESPONSE REGULATOR receiver
HRD70_13525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRD70_13530	COG2915	High frequency lysogenization protein hflD homolog
HRD70_13535	COG0482	sulfurtransferase activity
HRD70_13545	COG1187	pseudouridine synthase activity
HRD70_13550	COG0538	isocitrate dehydrogenase activity
HRD70_13555	COG0582	viral genome integration into host DNA
HRD70_13590	COG0840	transmembrane signaling receptor activity
HRD70_13595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRD70_13605	COG2873	o-acetylhomoserine
HRD70_13610	COG0702	epimerase
HRD70_13615	COG1733	regulation of RNA biosynthetic process
HRD70_13640	COG0765	amino acid transport
HRD70_13645	COG0765	amino acid transport
HRD70_13650	COG1126	abc transporter atp-binding protein
HRD70_13675	COG2203	Gaf domain
HRD70_13675	COG4251	negative regulation of phosphorylation
HRD70_13675	COG5001	Diguanylate cyclase
HRD70_13675	COG3706	GGDEF domain
HRD70_13685	COG1132	(ABC) transporter
HRD70_13705	COG2207	Transcriptional regulator
HRD70_13740	COG1113	amino acid transport
HRD70_13765	COG0768	penicillin binding
HRD70_13770	COG2226	methyltransferase
HRD70_13780	COG5001	Diguanylate cyclase
HRD70_13780	COG3447	MASE1 domain protein
HRD70_13780	COG5002	protein histidine kinase activity
HRD70_13790	COG1971	Probably functions as a manganese efflux pump
HRD70_13795	COG4811	Protein of unknown function (DUF986)
HRD70_13800	COG3716	PTS system mannose fructose sorbose family IID component
HRD70_13805	COG3715	PTS system
HRD70_13810	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD70_13810	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD70_13815	COG1253	flavin adenine dinucleotide binding
HRD70_13825	COG1760	l-serine dehydratase
HRD70_13830	COG0494	nUDIX hydrolase
HRD70_13840	COG3140	Belongs to the UPF0181 family
HRD70_13845	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HRD70_13850	COG0513	Belongs to the DEAD box helicase family
HRD70_13855	COG3141	response to X-ray
HRD70_13870	COG1770	oligopeptidase
HRD70_13875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD70_13890	COG1528	Iron-storage protein
HRD70_13895	COG2372	response to copper ion
HRD70_13900	COG1276	copper resistance
HRD70_14045	COG2974	May be involved in recombination
HRD70_14060	COG4725	Belongs to the MT-A70-like family
HRD70_14105	COG3772	lysozyme
HRD70_14270	COG1187	pseudouridine synthase activity
HRD70_14275	COG0786	glutamate:sodium symporter activity
HRD70_14295	COG0668	transmembrane transport
HRD70_14300	COG0625	glutathione transferase activity
HRD70_14325	COG5001	Diguanylate cyclase
HRD70_14325	COG4251	negative regulation of phosphorylation
HRD70_14325	COG3706	GGDEF domain
HRD70_14325	COG2203	Gaf domain
HRD70_14360	COG2814	Major facilitator Superfamily
HRD70_14370	COG3008	intermembrane lipid transfer
HRD70_14375	COG2995	paraquat-inducible protein a
HRD70_14380	COG1956	GAF domain-containing protein
HRD70_14390	COG0793	Belongs to the peptidase S41A family
HRD70_14395	COG0501	Belongs to the peptidase M48B family
HRD70_14405	COG3121	Chaperone
HRD70_14415	COG3121	Chaperone
HRD70_14425	COG3188	usher protein
HRD70_14435	COG2197	response regulator
HRD70_14440	COG0784	Response regulator, receiver
HRD70_14440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD70_14440	COG2198	Histidine kinase
HRD70_14440	COG2205	protein histidine kinase activity
HRD70_14445	COG2814	Major facilitator Superfamily
HRD70_14450	COG0823	Involved in the tonB-independent uptake of proteins
HRD70_14460	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRD70_14470	COG1988	membrane-bound metal-dependent
HRD70_14475	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD70_14480	COG1653	transport
HRD70_14485	COG3842	ATPase activity
HRD70_14490	COG0395	ABC-type sugar transport system, permease component
HRD70_14495	COG1175	transmembrane transport
HRD70_14505	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_14510	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HRD70_14515	COG1917	Cupin 2, conserved barrel domain protein
HRD70_14520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD70_14530	COG3001	Fructosamine kinase
HRD70_14535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD70_14540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD70_14545	COG1121	(ABC) transporter
HRD70_14550	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRD70_14585	COG4249	Peptidase C14 caspase catalytic subunit p20
HRD70_14605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRD70_14610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRD70_14640	COG0776	regulation of translation
HRD70_14645	COG3122	Protein conserved in bacteria
HRD70_14655	COG4139	cobalamin transport
HRD70_14660	COG0386	Belongs to the glutathione peroxidase family
HRD70_14665	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HRD70_14670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD70_14675	COG0463	Glycosyl transferase, family 2
HRD70_14680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRD70_14680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD70_14685	COG0726	polysaccharide deacetylase
HRD70_14690	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRD70_14695	COG2076	Multidrug Resistance protein
HRD70_14700	COG2076	Multidrug Resistance protein
HRD70_14705	COG0791	NLP P60 protein
HRD70_14710	COG0095	Lipoate-protein ligase
HRD70_14720	COG4558	Periplasmic binding protein
HRD70_14725	COG3720	iron ion transport
HRD70_14730	COG4771	TonB-dependent receptor
HRD70_14745	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HRD70_14750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD70_14750	COG0574	Belongs to the PEP-utilizing enzyme family
HRD70_14760	COG0628	permease
HRD70_14770	COG0277	FAD linked oxidase domain protein
HRD70_14770	COG0247	lactate metabolic process
HRD70_14775	COG2050	protein possibly involved in aromatic compounds catabolism
HRD70_14780	COG0316	Belongs to the HesB IscA family
HRD70_14785	COG0719	Fe-S assembly protein
HRD70_14790	COG0396	ATPase activity
HRD70_14795	COG0719	Fe-S assembly protein
HRD70_14805	COG2166	iron-sulfur cluster assembly
HRD70_14810	COG1376	ErfK ybiS ycfS ynhG family protein
HRD70_14810	COG1388	LysM domain
HRD70_14840	COG0534	Mate efflux family protein
HRD70_14845	COG0307	riboflavin synthase, alpha
HRD70_14850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRD70_14855	COG2814	Major facilitator Superfamily
HRD70_14860	COG0583	DNA-binding transcription factor activity
HRD70_14865	COG1609	Transcriptional regulator
HRD70_14880	COG0791	NLP P60 protein
HRD70_14885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HRD70_14890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD70_14895	COG0346	lactoylglutathione lyase activity
HRD70_14905	COG1902	pentaerythritol trinitrate reductase activity
HRD70_14910	COG1309	transcriptional regulator
HRD70_14915	COG2194	sulfuric ester hydrolase activity
HRD70_14920	COG3313	Fe-S protein
HRD70_14925	COG4989	oxidoreductase activity
HRD70_14930	COG1289	transmembrane transporter activity
HRD70_14935	COG1566	PFAM secretion protein HlyD family protein
HRD70_14945	COG1846	Transcriptional regulator
HRD70_14950	COG3133	Outer membrane lipoprotein
HRD70_14955	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HRD70_14960	COG3895	Periplasmic Protein
HRD70_14970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRD70_14980	COG0625	glutathione transferase activity
HRD70_15000	COG3104	oligopeptide transport
HRD70_15010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD70_15010	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD70_15015	COG4172	Belongs to the ABC transporter superfamily
HRD70_15025	COG4171	peptide transport system, permease
HRD70_15030	COG4168	peptide transport system, permease
HRD70_15035	COG4166	transmembrane transport
HRD70_15050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HRD70_15055	COG1842	Phage shock protein A
HRD70_15065	COG1983	PspC domain protein
HRD70_15075	COG3106	COG3106 Predicted ATPase
HRD70_15080	COG3768	UPF0283 membrane protein
HRD70_15085	COG5654	RES domain protein
HRD70_15090	COG5642	Protein of unknown function (DUF2384)
HRD70_15100	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HRD70_15105	COG4948	Mandelate Racemase Muconate Lactonizing
HRD70_15110	COG2866	Carboxypeptidase
HRD70_15115	COG4166	transmembrane transport
HRD70_15130	COG0037	tRNA processing
HRD70_15140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRD70_15140	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRD70_15140	COG1013	pyruvate-flavodoxin oxidoreductase activity
HRD70_15140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD70_15150	COG1285	pathogenesis
HRD70_15155	COG3042	response to heat
HRD70_15160	COG3187	Heat shock protein
HRD70_15165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRD70_15170	COG2911	Protein conserved in bacteria
HRD70_15180	COG3784	Protein of unknown function (DUF1318)
HRD70_15190	COG1070	Carbohydrate kinase
HRD70_15195	COG0246	Mannitol dehydrogenase
HRD70_15205	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRD70_15210	COG1643	Atp-dependent helicase
HRD70_15225	COG3591	Belongs to the peptidase S1B family
HRD70_15235	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HRD70_15240	COG2205	protein histidine kinase activity
HRD70_15245	COG0745	RESPONSE REGULATOR receiver
HRD70_15255	COG0531	amino acid
HRD70_15265	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HRD70_15270	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HRD70_15275	COG0589	response to stress
HRD70_15280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD70_15285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRD70_15300	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HRD70_15310	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_15330	COG1011	Hydrolase
HRD70_15340	COG0440	acetolactate synthase activity
HRD70_15345	COG0028	Belongs to the TPP enzyme family
HRD70_15360	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRD70_15385	COG0583	DNA-binding transcription factor activity
HRD70_15390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRD70_15415	COG4215	(ABC) transporter
HRD70_15425	COG1522	sequence-specific DNA binding
HRD70_15435	COG0625	glutathione transferase activity
HRD70_15475	COG0477	Major facilitator Superfamily
HRD70_15480	COG4221	oxidoreductase activity
HRD70_15485	COG1742	UPF0060 membrane protein
HRD70_15510	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HRD70_15515	COG1940	carbohydrate kinase activity
HRD70_15520	COG0583	DNA-binding transcription factor activity
HRD70_15525	COG2814	Major facilitator Superfamily
HRD70_15545	COG0114	fumarate hydratase activity
HRD70_15555	COG5339	Protein conserved in bacteria
HRD70_15565	COG1609	Transcriptional regulator
HRD70_15570	COG1263	PTS System
HRD70_15570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD70_15575	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRD70_15580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRD70_15585	COG0385	Bile acid
HRD70_15590	COG0673	inositol 2-dehydrogenase activity
HRD70_15605	COG2160	L-arabinose isomerase activity
HRD70_15610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRD70_15615	COG2274	protein secretion by the type I secretion system
HRD70_15630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HRD70_15650	COG4656	Part of a membrane complex involved in electron transport
HRD70_15655	COG3708	Transcriptional regulator
HRD70_15655	COG2207	Transcriptional regulator
HRD70_15660	COG4658	electron transport chain
HRD70_15665	COG4659	FMN binding
HRD70_15675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HRD70_15695	COG0243	molybdopterin cofactor binding
HRD70_15700	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HRD70_15705	COG1966	Carbon starvation protein
HRD70_15710	COG2879	small protein
HRD70_15715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRD70_15720	COG1349	DNA-binding transcription factor activity
HRD70_15740	COG0023	Translation Initiation Factor
HRD70_15745	COG0284	orotidine-5'-phosphate decarboxylase activity
HRD70_15770	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_15775	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HRD70_15780	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HRD70_15785	COG0671	phosphoesterase, PA-phosphatase related
HRD70_15810	COG0583	DNA-binding transcription factor activity
HRD70_15825	COG0616	signal peptide processing
HRD70_15830	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_15835	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HRD70_15845	COG1187	pseudouridine synthase activity
HRD70_15850	COG2197	response regulator
HRD70_15865	COG1470	cell adhesion involved in biofilm formation
HRD70_15865	COG1388	LysM domain
HRD70_15885	COG0009	L-threonylcarbamoyladenylate synthase
HRD70_15890	COG0613	PHP domain protein
HRD70_15900	COG0512	Glutamine amidotransferase of anthranilate synthase
HRD70_15910	COG0135	phosphoribosylanthranilate isomerase activity
HRD70_15910	COG0134	indole-3-glycerol-phosphate synthase activity
HRD70_15915	COG0133	tryptophan synthase activity
HRD70_15920	COG0159	tryptophan synthase activity
HRD70_15930	COG3047	cAMP biosynthetic process
HRD70_15935	COG0727	PFAM Uncharacterised protein family (UPF0153)
HRD70_15950	COG2917	probably involved in intracellular septation
HRD70_15955	COG1607	acyl-coa hydrolase
HRD70_15960	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HRD70_15965	COG2350	Protein conserved in bacteria
HRD70_15980	COG2200	EAL domain
HRD70_15990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRD70_15995	COG3099	Belongs to the UPF0263 family
HRD70_16000	COG4608	Belongs to the ABC transporter superfamily
HRD70_16005	COG0444	Belongs to the ABC transporter superfamily
HRD70_16010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD70_16030	COG2095	MarC family integral membrane protein
HRD70_16035	COG1012	belongs to the aldehyde dehydrogenase family
HRD70_16035	COG1454	alcohol dehydrogenase
HRD70_16045	COG2916	Histone family protein nucleoid-structuring protein H-NS
HRD70_16055	COG0745	RESPONSE REGULATOR receiver
HRD70_16060	COG1752	Esterase of the alpha-beta hydrolase superfamily
HRD70_16070	COG3012	SEC-C Motif Domain Protein
HRD70_16075	COG0788	formyltetrahydrofolate deformylase activity
HRD70_16090	COG0583	DNA-binding transcription factor activity
HRD70_16095	COG0708	Exodeoxyribonuclease III
HRD70_16100	COG0494	nUDIX hydrolase
HRD70_16110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRD70_16120	COG0778	Nitroreductase
HRD70_16125	COG0616	signal peptide processing
HRD70_16130	COG0252	asparaginase activity
HRD70_16135	COG1335	isochorismatase
HRD70_16140	COG3139	Protein of unknown function (DUF1315)
HRD70_16145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRD70_16160	COG3713	MltA-interacting MipA family protein
HRD70_16165	COG2766	serine protein kinase
HRD70_16170	COG2718	Belongs to the UPF0229 family
HRD70_16185	COG0583	DNA-binding transcription factor activity
HRD70_16195	COG2200	EAL domain
HRD70_16195	COG2202	Pas domain
HRD70_16195	COG2199	diguanylate cyclase activity
HRD70_16200	COG2814	Major facilitator Superfamily
HRD70_16205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRD70_16210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD70_16215	COG2719	SpoVR family
HRD70_16220	COG2186	Transcriptional regulator
HRD70_16225	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRD70_16230	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HRD70_16400	COG5484	DNA packaging
HRD70_16400	COG3728	DNA packaging
HRD70_16415	COG3772	lysozyme
HRD70_16470	COG0305	Participates in initiation and elongation during chromosome replication
HRD70_16570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD70_16620	COG0582	viral genome integration into host DNA
HRD70_16625	COG2983	Belongs to the UPF0260 family
HRD70_16630	COG0179	Fumarylacetoacetate (FAA) hydrolase
HRD70_16635	COG2951	lytic endotransglycosylase activity
HRD70_16640	COG3100	YcgL domain-containing protein
HRD70_16650	COG0850	regulation of cytokinetic process
HRD70_16655	COG2894	cell division
HRD70_16660	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HRD70_16665	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRD70_16670	COG0318	PFAM AMP-dependent synthetase and ligase
HRD70_16675	COG3065	identical protein binding
HRD70_16685	COG1199	ATP-dependent helicase activity
HRD70_16690	COG0251	oxidation-reduction process
HRD70_16695	COG2076	Multidrug Resistance protein
HRD70_16700	COG2076	Multidrug Resistance protein
HRD70_16705	COG0800	Aldolase
HRD70_16710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRD70_16715	COG1737	Transcriptional regulator
HRD70_16720	COG0469	pyruvate kinase activity
HRD70_16725	COG1560	Kdo2-lipid A biosynthetic process
HRD70_16730	COG0739	heme binding
HRD70_16735	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HRD70_16740	COG1121	(ABC) transporter
HRD70_16745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD70_16750	COG2255	four-way junction helicase activity
HRD70_16755	COG0632	four-way junction helicase activity
HRD70_16760	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRD70_16765	COG0217	transcriptional regulatory protein
HRD70_16770	COG0494	nUDIX hydrolase
HRD70_16775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRD70_16780	COG1335	isochorismatase
HRD70_16785	COG1801	Protein of unknown function DUF72
HRD70_16790	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HRD70_16795	COG2226	methyltransferase
HRD70_16800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD70_16805	COG3142	Participates in the control of copper homeostasis
HRD70_16810	COG3102	Protein conserved in bacteria
HRD70_16815	COG0018	arginyl-trna synthetase
HRD70_16825	COG0728	peptidoglycan biosynthetic process
HRD70_16830	COG0673	inositol 2-dehydrogenase activity
HRD70_16840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD70_16845	COG0477	Major facilitator Superfamily
HRD70_16855	COG3381	protein complex oligomerization
HRD70_16860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HRD70_16865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD70_16885	COG3706	GGDEF domain
HRD70_16890	COG0659	secondary active sulfate transmembrane transporter activity
HRD70_16895	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HRD70_16910	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD70_16915	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRD70_16920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HRD70_16925	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HRD70_16935	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRD70_16945	COG0193	aminoacyl-tRNA hydrolase activity
HRD70_16955	COG0012	GTP binding
HRD70_16960	COG2315	Protein conserved in bacteria
HRD70_16965	COG1349	DNA-binding transcription factor activity
HRD70_16975	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD70_16985	COG3716	PTS system mannose fructose sorbose family IID component
HRD70_16990	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD70_16995	COG2222	sugar isomerase
HRD70_17000	COG0191	fructose-bisphosphate aldolase activity
HRD70_17010	COG4942	peptidase
HRD70_17020	COG3443	Belongs to the bacterial solute-binding protein 9 family
HRD70_17025	COG4211	Belongs to the binding-protein-dependent transport system permease family
HRD70_17030	COG1129	ABC transporter
HRD70_17045	COG0402	S-adenosylhomocysteine deaminase activity
HRD70_17055	COG1228	amidohydrolase
HRD70_17070	COG2988	succinylglutamate desuccinylase activity
HRD70_17075	COG3724	N-succinylarginine dihydrolase activity
HRD70_17085	COG3138	arginine N-succinyltransferase
HRD70_17100	COG1271	oxidase subunit
HRD70_17105	COG1294	oxidase, subunit
HRD70_17115	COG3850	Histidine kinase
HRD70_17120	COG0583	DNA-binding transcription factor activity
HRD70_17130	COG0387	Pfam Sodium calcium exchanger
HRD70_17135	COG1702	phosphate starvation-inducible protein PhoH
HRD70_17145	COG3658	cytochrome
HRD70_17150	COG1215	transferase activity, transferring glycosyl groups
HRD70_17155	COG1649	PFAM Uncharacterised BCR, COG1649
HRD70_17155	COG0726	polysaccharide deacetylase
HRD70_17160	COG0457	Tetratricopeptide repeat
HRD70_17165	COG0006	proline dipeptidase activity
HRD70_17170	COG4114	ferric iron reductase
HRD70_17175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRD70_17200	COG0577	efflux transmembrane transporter activity
HRD70_17200	COG1136	(ABC) transporter
HRD70_17210	COG0577	efflux transmembrane transporter activity
HRD70_17210	COG1136	(ABC) transporter
HRD70_17225	COG0672	)-iron permease
HRD70_17245	COG2066	Belongs to the glutaminase family
HRD70_17250	COG3622	Belongs to the hyi family
HRD70_17255	COG0235	Class ii aldolase
HRD70_17260	COG3395	kinase activity
HRD70_17265	COG1349	DNA-binding transcription factor activity
HRD70_17270	COG3290	protein histidine kinase activity
HRD70_17275	COG4565	transcriptional regulatory protein
HRD70_17280	COG3493	citrate carrier protein
HRD70_17295	COG0346	lactoylglutathione lyase activity
HRD70_17305	COG2223	nitrite transmembrane transporter activity
HRD70_17310	COG0561	phosphatase activity
HRD70_17325	COG4974	Belongs to the 'phage' integrase family
HRD70_17395	COG2176	DNA-directed DNA polymerase activity
HRD70_17395	COG5002	protein histidine kinase activity
HRD70_17425	COG4695	Portal protein
HRD70_17575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRD70_17580	COG0322	excinuclease ABC activity
HRD70_17585	COG2197	response regulator
HRD70_17595	COG3136	membrane protein required for alginate biosynthesis
HRD70_17605	COG0366	Alpha amylase catalytic
HRD70_17615	COG2226	methyltransferase
HRD70_17620	COG2246	polysaccharide biosynthetic process
HRD70_17655	COG1113	amino acid transport
HRD70_17665	COG1881	PFAM PEBP family protein
HRD70_17670	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HRD70_17680	COG0655	NAD(P)H dehydrogenase (quinone) activity
HRD70_17695	COG0672	)-iron permease
HRD70_17705	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRD70_17705	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRD70_17705	COG0506	proline dehydrogenase activity
HRD70_17735	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HRD70_17745	COG1191	sigma factor activity
HRD70_17775	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HRD70_17780	COG4572	Cation transport regulator
HRD70_17790	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HRD70_17795	COG1677	Flagellar hook-basal body complex protein FliE
HRD70_17810	COG1317	bacterial-type flagellum organization
HRD70_17815	COG1157	protein secretion by the type III secretion system
HRD70_17830	COG1580	Controls the rotational direction of flagella during chemotaxis
HRD70_17865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRD70_17870	COG1256	bacterial-type flagellum assembly
HRD70_17900	COG1749	Flagellar hook protein flgE
HRD70_17905	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HRD70_17910	COG1558	bacterial-type flagellum-dependent cell motility
HRD70_17915	COG1815	bacterial-type flagellum-dependent cell motility
HRD70_17925	COG2747	anti-sigma28 factor FlgM
HRD70_17930	COG3418	PFAM FlgN family protein
HRD70_17950	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD70_17955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD70_17960	COG4935	Belongs to the peptidase S8 family
HRD70_17960	COG1404	Belongs to the peptidase S8 family
HRD70_17965	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HRD70_17970	COG0745	RESPONSE REGULATOR receiver
HRD70_17980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HRD70_17985	COG0840	transmembrane signaling receptor activity
HRD70_17990	COG0840	transmembrane signaling receptor activity
HRD70_17995	COG1045	serine acetyltransferase
HRD70_18000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRD70_18010	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HRD70_18020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD70_18025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRD70_18030	COG0835	chemotaxis
HRD70_18035	COG2198	Histidine kinase
HRD70_18035	COG0643	Histidine kinase
HRD70_18040	COG1360	Flagellar Motor Protein
HRD70_18060	COG0589	response to stress
HRD70_18065	COG2130	NADP-dependent
HRD70_18075	COG1285	pathogenesis
HRD70_18080	COG0840	transmembrane signaling receptor activity
HRD70_18095	COG1609	Transcriptional regulator
HRD70_18100	COG3250	beta-galactosidase activity
HRD70_18105	COG1028	Short-chain dehydrogenase reductase Sdr
HRD70_18105	COG3321	synthase
HRD70_18105	COG0604	alcohol dehydrogenase
HRD70_18135	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRD70_18140	COG3121	Chaperone
HRD70_18165	COG1070	Carbohydrate kinase
HRD70_18170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD70_18180	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD70_18185	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD70_18210	COG3228	Belongs to the MtfA family
HRD70_18240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRD70_18255	COG0471	metal ion transport
HRD70_18265	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HRD70_18265	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
HRD70_18270	COG3051	citrate lyase alpha subunit
HRD70_18275	COG2301	Belongs to the HpcH HpaI aldolase family
HRD70_18280	COG3052	prosthetic group binding
HRD70_18285	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HRD70_18290	COG3290	protein histidine kinase activity
HRD70_18295	COG4565	transcriptional regulatory protein
HRD70_18315	COG1840	ABC-type Fe3 transport system, periplasmic component
HRD70_18325	COG3842	ATPase activity
HRD70_18340	COG2205	protein histidine kinase activity
HRD70_18340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD70_18350	COG3121	Chaperone
HRD70_18365	COG3121	Chaperone
HRD70_18395	COG1129	ABC transporter
HRD70_18405	COG4221	oxidoreductase activity
HRD70_18410	COG0667	Aldo Keto reductase
HRD70_18420	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD70_18425	COG0784	Response regulator, receiver
HRD70_18425	COG0835	chemotaxis
HRD70_18430	COG0583	DNA-binding transcription factor activity
HRD70_18445	COG1349	DNA-binding transcription factor activity
HRD70_18450	COG0561	phosphatase activity
HRD70_18455	COG0352	thiamine-phosphate diphosphorylase activity
HRD70_18475	COG0534	Mate efflux family protein
HRD70_18480	COG0137	argininosuccinate synthase activity
HRD70_18485	COG2211	Major facilitator Superfamily
HRD70_18490	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HRD70_18500	COG0583	DNA-binding transcription factor activity
HRD70_18505	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HRD70_18525	COG1492	cobalamin metabolic process
HRD70_18590	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HRD70_18600	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HRD70_18675	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HRD70_18685	COG1012	belongs to the aldehyde dehydrogenase family
HRD70_18695	COG4656	Part of a membrane complex involved in electron transport
HRD70_18715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HRD70_18720	COG1648	precorrin-2 dehydrogenase activity
HRD70_18720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRD70_18725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD70_18740	COG1129	ABC transporter
HRD70_18745	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD70_18750	COG4214	carbohydrate transport
HRD70_18760	COG1289	transmembrane transporter activity
HRD70_18765	COG1022	Amp-dependent synthetase and ligase
HRD70_18765	COG3320	Male sterility
HRD70_18770	COG2925	Exonuclease
HRD70_18775	COG0531	amino acid
HRD70_18780	COG0371	Dehydrogenase
HRD70_18785	COG1129	ABC transporter
HRD70_18790	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD70_18795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD70_18805	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRD70_18815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD70_18820	COG0131	Imidazoleglycerol-phosphate dehydratase
HRD70_18820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HRD70_18830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRD70_18835	COG0107	imidazoleglycerol-phosphate synthase activity
HRD70_18840	COG0140	phosphoribosyl-ATP diphosphatase activity
HRD70_18840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRD70_18850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRD70_18855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRD70_18860	COG1253	flavin adenine dinucleotide binding
HRD70_18865	COG3069	C4-dicarboxylate transmembrane transporter activity
HRD70_18870	COG2982	Protein involved in outer membrane biogenesis
HRD70_18875	COG0717	Belongs to the dCTP deaminase family
HRD70_18880	COG0572	uridine kinase
HRD70_18885	COG0489	protein tyrosine kinase activity
HRD70_18890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD70_18890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD70_18910	COG2814	Major facilitator Superfamily
HRD70_18915	COG1380	Effector of murein hydrolase LrgA
HRD70_18920	COG1346	cytolysis
HRD70_18935	COG0281	malic enzyme
HRD70_18940	COG2949	membrane
HRD70_18945	COG0298	carbon dioxide binding
HRD70_18950	COG0375	protein maturation
HRD70_18955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD70_18960	COG0651	ATP synthesis coupled electron transport
HRD70_18965	COG0650	Formate hydrogenlyase subunit 4
HRD70_18970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRD70_18975	COG4237	Hydrogenase 4 membrane
HRD70_18980	COG0651	ATP synthesis coupled electron transport
HRD70_18985	COG3261	NADH dehydrogenase
HRD70_18985	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HRD70_18990	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD70_18995	COG3260	NADH ubiquinone oxidoreductase 20
HRD70_19005	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HRD70_19010	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD70_19015	COG3383	formate dehydrogenase (NAD+) activity
HRD70_19020	COG3604	Transcriptional regulator
HRD70_19025	COG2116	formate transmembrane transporter activity
HRD70_19045	COG1609	Transcriptional regulator
HRD70_19050	COG2311	Membrane
HRD70_19055	COG0302	gtp cyclohydrolase
HRD70_19060	COG0477	Major facilitator Superfamily
HRD70_19065	COG0583	DNA-binding transcription factor activity
HRD70_19105	COG0477	Major facilitator Superfamily
HRD70_19115	COG0303	'Molybdopterin
HRD70_19125	COG0488	(ABC) transporter
HRD70_19135	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HRD70_19150	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HRD70_19165	COG4106	trans-aconitate 2-methyltransferase activity
HRD70_19170	COG0783	Belongs to the Dps family
HRD70_19175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD70_19180	COG0765	amino acid transport
HRD70_19185	COG1126	abc transporter atp-binding protein
HRD70_19195	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HRD70_19215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRD70_19220	COG0583	DNA-binding transcription factor activity
HRD70_19230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRD70_19235	COG1199	ATP-dependent helicase activity
HRD70_19250	COG0697	spore germination
HRD70_19265	COG1174	glycine betaine transport
HRD70_19270	COG1125	glycine betaine transport
HRD70_19275	COG1174	glycine betaine transport
HRD70_19280	COG1732	Glycine betaine
HRD70_19295	COG2897	thiosulfate sulfurtransferase activity
HRD70_19300	COG4807	Protein conserved in bacteria
HRD70_19315	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HRD70_19325	COG2261	transglycosylase associated protein
HRD70_19345	COG0277	FAD linked oxidase domain protein
HRD70_19350	COG1686	Belongs to the peptidase S11 family
HRD70_19360	COG2239	Acts as a magnesium transporter
HRD70_19370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD70_19375	COG0513	Belongs to the DEAD box helicase family
HRD70_19380	COG1309	transcriptional regulator
HRD70_19385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD70_19390	COG1131	(ABC) transporter
HRD70_19395	COG0842	Transport permease protein
HRD70_19400	COG0842	Transport permease protein
HRD70_19405	COG0670	Belongs to the BI1 family
HRD70_19410	COG0314	molybdopterin synthase activity
HRD70_19415	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HRD70_19420	COG0315	cyclic pyranopterin monophosphate synthase activity
HRD70_19425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRD70_19430	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HRD70_19435	COG4628	conserved protein (DUF2132)
HRD70_19440	COG0556	nucleotide-excision repair
HRD70_19455	COG2226	methyltransferase
HRD70_19460	COG0156	8-amino-7-oxononanoate synthase activity
HRD70_19465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRD70_19475	COG2706	6-phosphogluconolactonase activity
HRD70_19480	COG0561	phosphatase activity
HRD70_19490	COG4149	molybdate abc transporter
HRD70_19495	COG0725	ABC transporter, periplasmic molybdate-binding protein
HRD70_19505	COG3585	molybdate ion transport
HRD70_19505	COG2005	Transcriptional regulator
HRD70_19510	COG1119	ATPase activity
HRD70_19520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRD70_19525	COG1085	galactose-1-phosphate uridylyltransferase
HRD70_19530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HRD70_19535	COG2017	converts alpha-aldose to the beta-anomer
HRD70_19545	COG0588	phosphoglycerate mutase activity
HRD70_19550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRD70_19555	COG1230	cation diffusion facilitator family transporter
HRD70_19565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HRD70_19605	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HRD70_19610	COG2885	chlorophyll binding
HRD70_19615	COG0823	Involved in the tonB-independent uptake of proteins
HRD70_19620	COG3064	Membrane
HRD70_19620	COG3064	Membrane
HRD70_19625	COG0848	biopolymer transport protein
HRD70_19630	COG0811	peptide transport
HRD70_19635	COG0824	Thioesterase
HRD70_19640	COG3790	cyd operon protein YbgE
HRD70_19645	COG4890	Cyd operon protein YbgT
HRD70_19650	COG1294	oxidase, subunit
HRD70_19655	COG1271	oxidase subunit
HRD70_19660	COG0737	Belongs to the 5'-nucleotidase family
HRD70_19665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HRD70_19675	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD70_19680	COG0567	Dehydrogenase, E1 component
HRD70_19690	COG1053	succinate dehydrogenase
HRD70_19695	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HRD70_19700	COG2009	succinate dehydrogenase
HRD70_19710	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HRD70_19725	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HRD70_19730	COG1984	allophanate hydrolase subunit 2
HRD70_19735	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HRD70_19740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRD70_19745	COG5212	phosphodiesterase
HRD70_19755	COG3272	Protein of unknown function (DUF1722)
HRD70_19760	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HRD70_19760	COG3064	Membrane
HRD70_19760	COG1073	alpha beta
HRD70_19760	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HRD70_19760	COG3064	Membrane
HRD70_19760	COG1073	alpha beta
HRD70_19765	COG2994	toxin metabolic process
HRD70_19785	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HRD70_19790	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HRD70_19795	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HRD70_19800	COG2205	protein histidine kinase activity
HRD70_19805	COG0745	RESPONSE REGULATOR receiver
HRD70_19820	COG0033	Phosphoglucomutase
HRD70_19825	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HRD70_19830	COG0840	transmembrane signaling receptor activity
HRD70_19835	COG0596	Alpha beta hydrolase
HRD70_19845	COG0840	transmembrane signaling receptor activity
HRD70_19855	COG0735	belongs to the Fur family
HRD70_19880	COG1263	PTS System
HRD70_19880	COG2190	(PTS) system
HRD70_19880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD70_19885	COG0363	glucosamine-6-phosphate deaminase activity
HRD70_19890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRD70_19895	COG1846	Transcriptional regulator
HRD70_19895	COG1940	carbohydrate kinase activity
HRD70_19900	COG0647	UMP catabolic process
HRD70_19905	COG0367	asparagine synthase
HRD70_19940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD70_19945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRD70_19950	COG1702	phosphate starvation-inducible protein PhoH
HRD70_19955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRD70_19965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRD70_19980	COG0765	amino acid transport
HRD70_19985	COG0765	amino acid transport
HRD70_19990	COG1126	abc transporter atp-binding protein
HRD70_20000	COG2888	peptidyl-tyrosine sulfation
HRD70_20005	COG0495	leucyl-tRNA aminoacylation
HRD70_20010	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HRD70_20015	COG1466	dna polymerase III delta subunit
HRD70_20020	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRD70_20025	COG0799	negative regulation of ribosome biogenesis
HRD70_20035	COG0768	penicillin binding
HRD70_20040	COG0772	Belongs to the SEDS family
HRD70_20045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRD70_20050	COG1686	Belongs to the peptidase S11 family
HRD70_20055	COG2921	Belongs to the UPF0250 family
HRD70_20060	COG0321	lipoyl(octanoyl) transferase activity
HRD70_20065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRD70_20070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD70_20075	COG3706	GGDEF domain
HRD70_20090	COG1278	Cold shock
HRD70_20095	COG2197	response regulator
HRD70_20120	COG5265	(ABC) transporter
HRD70_20125	COG1309	transcriptional regulator
HRD70_20130	COG3250	beta-galactosidase activity
HRD70_20145	COG2850	peptidyl-arginine hydroxylation
HRD70_20160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HRD70_20430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD70_20485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRD70_20490	COG2501	S4 domain
HRD70_20495	COG0215	cysteine-tRNA ligase activity
HRD70_20500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRD70_20505	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD70_20510	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRD70_20515	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HRD70_20520	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HRD70_20525	COG4181	ATPase activity
HRD70_20530	COG2755	lipolytic protein G-D-S-L family
HRD70_20535	COG0300	oxidoreductase activity
HRD70_20540	COG3118	belongs to the thioredoxin family
HRD70_20545	COG0330	HflC and HflK could
HRD70_20550	COG1585	Membrane protein implicated in regulation of membrane protease activity
HRD70_20555	COG0789	Transcriptional regulator
HRD70_20560	COG2217	Heavy metal translocating P-type atpase
HRD70_20565	COG3735	TraB family
HRD70_20570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRD70_20575	COG0737	Belongs to the 5'-nucleotidase family
HRD70_20580	COG2223	nitrite transmembrane transporter activity
HRD70_20585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRD70_20585	COG4651	solute:proton antiporter activity
HRD70_20590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD70_20610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRD70_20615	COG0297	glycogen (starch) synthase activity
HRD70_20620	COG0438	transferase activity, transferring glycosyl groups
HRD70_20625	COG1215	transferase activity, transferring glycosyl groups
HRD70_20630	COG1216	Glycosyl transferase, family 2
HRD70_20630	COG1442	glycosyl transferase family 8
HRD70_20635	COG2244	polysaccharide biosynthetic process
HRD70_20640	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRD70_20645	COG0563	adenylate kinase activity
HRD70_20650	COG0326	Molecular chaperone. Has ATPase activity
HRD70_20655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRD70_20660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HRD70_20665	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRD70_20685	COG3210	domain, Protein
HRD70_20715	COG3210	domain, Protein
HRD70_20720	COG2831	hemolysin activation secretion protein
HRD70_20725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRD70_20730	COG2832	Protein of unknown function (DUF454)
HRD70_20745	COG1196	nuclear chromosome segregation
HRD70_20745	COG3264	Mechanosensitive ion channel
HRD70_20750	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HRD70_20755	COG1309	transcriptional regulator
HRD70_20760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD70_20765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD70_20775	COG3457	Alanine racemase
HRD70_20780	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HRD70_20795	COG0254	rRNA binding
HRD70_20800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRD70_20805	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRD70_20810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD70_20840	COG3695	enzyme binding
HRD70_20845	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HRD70_20850	COG1946	Acyl-CoA thioesterase
HRD70_20855	COG0004	ammonium transporteR
HRD70_20860	COG0347	Belongs to the P(II) protein family
HRD70_20865	COG1132	(ABC) transporter
HRD70_20870	COG1132	(ABC) transporter
HRD70_20875	COG1522	sequence-specific DNA binding
HRD70_20885	COG0561	phosphatase activity
HRD70_20890	COG4533	DNA binding
HRD70_20895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRD70_20900	COG0824	Thioesterase
HRD70_20905	COG1555	photosystem II stabilization
HRD70_20910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRD70_20915	COG0776	regulation of translation
HRD70_20920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRD70_20925	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRD70_20935	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRD70_20940	COG0271	Belongs to the BolA IbaG family
HRD70_20945	COG3056	Lipoprotein
HRD70_20950	COG2223	nitrite transmembrane transporter activity
HRD70_20965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HRD70_20970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRD70_20975	COG1845	cytochrome c oxidase, subunit III
HRD70_20980	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HRD70_20985	COG0109	protoheme IX farnesyltransferase activity
HRD70_20990	COG2814	Major facilitator Superfamily
HRD70_20995	COG1666	GTP binding
HRD70_21000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HRD70_21010	COG0301	tRNA thio-modification
HRD70_21010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRD70_21015	COG1722	exodeoxyribonuclease VII activity
HRD70_21020	COG0142	geranyltranstransferase activity
HRD70_21025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRD70_21030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HRD70_21035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HRD70_21040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRD70_21045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HRD70_21050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRD70_21050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRD70_21065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRD70_21070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRD70_21075	COG1862	Preprotein translocase
HRD70_21080	COG0343	queuine tRNA-ribosyltransferase activity
HRD70_21190	COG5410	chromosome segregation
HRD70_21225	COG3772	lysozyme
HRD70_21260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRD70_21320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRD70_21350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD70_21400	COG0582	viral genome integration into host DNA
HRD70_21410	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HRD70_21415	COG0450	alkyl hydroperoxide reductase
HRD70_21430	COG0366	Alpha amylase catalytic
HRD70_21450	COG5002	protein histidine kinase activity
HRD70_21455	COG0745	RESPONSE REGULATOR receiver
HRD70_21460	COG0420	3'-5' exonuclease activity
HRD70_21465	COG0419	ATPase involved in DNA repair
HRD70_21470	COG1940	carbohydrate kinase activity
HRD70_21475	COG2974	May be involved in recombination
HRD70_21480	COG3123	guanosine phosphorylase activity
HRD70_21485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRD70_21495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRD70_21510	COG2226	methyltransferase
HRD70_21525	COG3459	Glycosyltransferase 36 associated
HRD70_21545	COG2188	Transcriptional regulator
HRD70_21550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD70_21555	COG2313	pseudouridylate synthase activity
HRD70_21560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD70_21565	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRD70_21570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRD70_21585	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HRD70_21590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRD70_21605	COG0438	transferase activity, transferring glycosyl groups
HRD70_21630	COG1086	Polysaccharide biosynthesis protein
HRD70_21650	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HRD70_21655	COG2195	Cleaves the N-terminal amino acid of tripeptides
HRD70_21660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRD70_21675	COG2964	Protein conserved in bacteria
HRD70_21690	COG2991	Protein conserved in bacteria
HRD70_21695	COG1477	protein flavinylation
HRD70_21700	COG2871	sodium ion transport
HRD70_21705	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD70_21710	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD70_21715	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD70_21720	COG1805	sodium ion transport
HRD70_21725	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD70_21730	COG3034	peptidoglycan biosynthetic process
HRD70_21735	COG0121	glutamine amidotransferase
HRD70_21745	COG1960	acyl-CoA dehydrogenase activity
HRD70_21750	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
HRD70_21760	COG2831	hemolysin activation secretion protein
HRD70_21765	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HRD70_21770	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HRD70_21775	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HRD70_21780	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HRD70_21785	COG0235	Class ii aldolase
HRD70_21795	COG0436	Aminotransferase
HRD70_21810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HRD70_21820	COG0765	amino acid transport
HRD70_21825	COG0765	amino acid transport
HRD70_21885	COG2814	Major facilitator Superfamily
HRD70_21890	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HRD70_21900	COG1846	Transcriptional regulator
HRD70_21905	COG1538	Outer membrane efflux protein
HRD70_21910	COG1566	PFAM secretion protein HlyD family protein
HRD70_21915	COG2814	Major facilitator Superfamily
HRD70_21920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD70_21925	COG3118	belongs to the thioredoxin family
HRD70_21940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRD70_21945	COG5544	Lipoprotein
HRD70_21980	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HRD70_21990	COG2011	ABC-type metal ion transport system permease component
HRD70_21995	COG1464	Belongs to the NlpA lipoprotein family
HRD70_22005	COG1720	tRNA m6t6A37 methyltransferase activity
HRD70_22010	COG0442	prolyl-tRNA aminoacylation
HRD70_22015	COG3015	lipoprotein NlpE involved in copper resistance
HRD70_22025	COG4681	YaeQ
HRD70_22035	COG4568	rho-dependent transcription termination
HRD70_22050	COG0346	lactoylglutathione lyase activity
HRD70_22060	COG0825	malonyl-CoA metabolic process
HRD70_22065	COG0587	DNA-directed DNA polymerase activity
HRD70_22070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRD70_22080	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD70_22085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRD70_22090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD70_22095	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HRD70_22105	COG0750	zinc metalloprotease
HRD70_22110	COG0575	Belongs to the CDS family
HRD70_22120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRD70_22125	COG0233	cytoplasmic translational termination
HRD70_22130	COG0528	UMP kinase activity
HRD70_22135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRD70_22140	COG0052	Belongs to the universal ribosomal protein uS2 family