locus-tag	class	description
CH54_1	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH54_1	COG0116	Belongs to the methyltransferase superfamily
CH54_10	COG1067	ATP-dependent peptidase activity
CH54_100	COG1252	NADH dehydrogenase
CH54_1000	COG1380	Effector of murein hydrolase LrgA
CH54_1001	COG1346	cytolysis
CH54_1004	COG0281	malic enzyme
CH54_1005	COG2949	membrane
CH54_1006	COG0298	carbon dioxide binding
CH54_1007	COG0375	protein maturation
CH54_1008	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH54_1009	COG0651	ATP synthesis coupled electron transport
CH54_1010	COG0650	Formate hydrogenlyase subunit 4
CH54_1011	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH54_1012	COG4237	Hydrogenase 4 membrane
CH54_1013	COG0651	ATP synthesis coupled electron transport
CH54_1014	COG3261	NADH dehydrogenase
CH54_1014	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CH54_1015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH54_1016	COG3260	NADH ubiquinone oxidoreductase 20
CH54_1018	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH54_1019	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH54_102	COG3134	Outer membrane lipoprotein
CH54_1020	COG3383	formate dehydrogenase (NAD+) activity
CH54_1021	COG3604	Transcriptional regulator
CH54_1022	COG2116	formate transmembrane transporter activity
CH54_1027	COG2311	Membrane
CH54_1028	COG0302	gtp cyclohydrolase
CH54_1029	COG0477	Major facilitator Superfamily
CH54_103	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH54_1030	COG0583	DNA-binding transcription factor activity
CH54_1036	COG1136	(ABC) transporter
CH54_1036	COG0577	efflux transmembrane transporter activity
CH54_1038	COG0477	Major facilitator Superfamily
CH54_104	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH54_1040	COG0303	'Molybdopterin
CH54_1041	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH54_1042	COG0488	(ABC) transporter
CH54_1044	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH54_1047	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CH54_1050	COG4106	trans-aconitate 2-methyltransferase activity
CH54_1051	COG0783	Belongs to the Dps family
CH54_1052	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_1053	COG0765	amino acid transport
CH54_1054	COG1126	abc transporter atp-binding protein
CH54_1056	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CH54_1059	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH54_106	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH54_1060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH54_1061	COG1199	ATP-dependent helicase activity
CH54_1064	COG0697	spore germination
CH54_1067	COG1174	glycine betaine transport
CH54_1068	COG1125	glycine betaine transport
CH54_1069	COG1174	glycine betaine transport
CH54_107	COG1940	carbohydrate kinase activity
CH54_1070	COG1732	Glycine betaine
CH54_1073	COG2897	thiosulfate sulfurtransferase activity
CH54_1074	COG4807	Protein conserved in bacteria
CH54_1077	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CH54_1079	COG2261	transglycosylase associated protein
CH54_108	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH54_1081	COG1403	HNH endonuclease
CH54_1083	COG0277	FAD linked oxidase domain protein
CH54_1084	COG1686	Belongs to the peptidase S11 family
CH54_1086	COG2239	Acts as a magnesium transporter
CH54_1088	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH54_1089	COG0513	Belongs to the DEAD box helicase family
CH54_1090	COG1309	transcriptional regulator
CH54_1091	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_1092	COG1131	(ABC) transporter
CH54_1093	COG0842	Transport permease protein
CH54_1094	COG0842	Transport permease protein
CH54_1095	COG0670	Belongs to the BI1 family
CH54_1096	COG0314	molybdopterin synthase activity
CH54_1097	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH54_1098	COG0315	cyclic pyranopterin monophosphate synthase activity
CH54_1099	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH54_11	COG3120	sequence-specific DNA binding
CH54_110	COG2850	peptidyl-arginine hydroxylation
CH54_1100	COG4628	conserved protein (DUF2132)
CH54_1101	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH54_1102	COG0556	nucleotide-excision repair
CH54_1103	COG0410	ABC transporter
CH54_1104	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH54_1105	COG2226	methyltransferase
CH54_1106	COG0156	8-amino-7-oxononanoate synthase activity
CH54_1107	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CH54_1109	COG2706	6-phosphogluconolactonase activity
CH54_1110	COG0561	phosphatase activity
CH54_1112	COG4149	molybdate abc transporter
CH54_1113	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH54_1115	COG2005	Transcriptional regulator
CH54_1115	COG3585	molybdate ion transport
CH54_1116	COG1119	ATPase activity
CH54_1118	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH54_112	COG0745	RESPONSE REGULATOR receiver
CH54_1120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CH54_1121	COG2017	converts alpha-aldose to the beta-anomer
CH54_1123	COG0588	phosphoglycerate mutase activity
CH54_1124	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH54_1125	COG1230	cation diffusion facilitator family transporter
CH54_1127	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CH54_1132	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH54_1133	COG2885	chlorophyll binding
CH54_1134	COG0823	Involved in the tonB-independent uptake of proteins
CH54_1135	COG3064	Membrane
CH54_1135	COG3064	Membrane
CH54_1136	COG0848	biopolymer transport protein
CH54_1137	COG0811	peptide transport
CH54_1138	COG0824	Thioesterase
CH54_1139	COG3790	cyd operon protein YbgE
CH54_114	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH54_1140	COG4890	Cyd operon protein YbgT
CH54_1141	COG1294	oxidase, subunit
CH54_1142	COG1271	oxidase subunit
CH54_1143	COG0737	Belongs to the 5'-nucleotidase family
CH54_1144	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH54_1146	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH54_1147	COG0567	Dehydrogenase, E1 component
CH54_1149	COG1053	succinate dehydrogenase
CH54_115	COG2915	High frequency lysogenization protein hflD homolog
CH54_1150	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH54_1151	COG2009	succinate dehydrogenase
CH54_1153	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CH54_1156	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CH54_1157	COG1984	allophanate hydrolase subunit 2
CH54_1158	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH54_1159	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH54_116	COG0482	sulfurtransferase activity
CH54_1160	COG5212	phosphodiesterase
CH54_1162	COG3272	Protein of unknown function (DUF1722)
CH54_1164	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CH54_1165	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CH54_1166	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CH54_1167	COG2205	protein histidine kinase activity
CH54_1168	COG0745	RESPONSE REGULATOR receiver
CH54_1171	COG0033	Phosphoglucomutase
CH54_1172	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH54_1173	COG0596	Alpha beta hydrolase
CH54_1176	COG0840	transmembrane signaling receptor activity
CH54_1178	COG0735	belongs to the Fur family
CH54_118	COG1187	pseudouridine synthase activity
CH54_1182	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH54_1183	COG1263	PTS System
CH54_1183	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_1183	COG2190	(PTS) system
CH54_1184	COG0363	glucosamine-6-phosphate deaminase activity
CH54_1185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH54_1186	COG1940	carbohydrate kinase activity
CH54_1186	COG1846	Transcriptional regulator
CH54_1187	COG0647	UMP catabolic process
CH54_1188	COG0367	asparagine synthase
CH54_119	COG0538	isocitrate dehydrogenase activity
CH54_1195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH54_1196	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CH54_1197	COG1702	phosphate starvation-inducible protein PhoH
CH54_1198	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CH54_1199	COG4535	Mg2 and Co2 transporter CorC
CH54_12	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH54_12	COG2885	chlorophyll binding
CH54_1200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH54_1203	COG0765	amino acid transport
CH54_1204	COG0765	amino acid transport
CH54_1205	COG1126	abc transporter atp-binding protein
CH54_1207	COG2888	peptidyl-tyrosine sulfation
CH54_1209	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CH54_1210	COG1466	dna polymerase III delta subunit
CH54_1211	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CH54_1212	COG0799	negative regulation of ribosome biogenesis
CH54_1214	COG0768	penicillin binding
CH54_1215	COG0772	Belongs to the SEDS family
CH54_1216	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH54_1217	COG1686	Belongs to the peptidase S11 family
CH54_1218	COG2921	Belongs to the UPF0250 family
CH54_1219	COG0321	lipoyl(octanoyl) transferase activity
CH54_1220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CH54_1221	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH54_1222	COG3706	GGDEF domain
CH54_1223	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH54_1224	COG1278	Cold shock
CH54_1225	COG1278	Cold shock
CH54_1226	COG2197	response regulator
CH54_1231	COG5265	(ABC) transporter
CH54_1232	COG2850	peptidyl-arginine hydroxylation
CH54_1233	COG2824	Alkylphosphonate utilization operon protein PhnA
CH54_1237	COG2723	6-phospho-beta-galactosidase activity
CH54_1238	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_1238	COG1263	PTS System
CH54_1239	COG1609	Transcriptional regulator
CH54_1240	COG2353	YceI-like domain
CH54_1241	COG3038	cytochrome b561
CH54_1244	COG1127	ABC transporter
CH54_1245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH54_1249	COG0531	amino acid
CH54_1250	COG2951	lytic endotransglycosylase activity
CH54_1254	COG1280	lysine exporter protein (LysE YggA)
CH54_1256	COG0243	molybdopterin cofactor binding
CH54_1257	COG0437	4 iron, 4 sulfur cluster binding
CH54_1258	COG3302	dmso reductase anchor subunit
CH54_1259	COG3381	protein complex oligomerization
CH54_126	COG0840	transmembrane signaling receptor activity
CH54_1265	COG3038	cytochrome b561
CH54_1266	COG0436	Aminotransferase
CH54_1269	COG3275	phosphorelay sensor kinase activity
CH54_127	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH54_1270	COG3279	Response regulator of the LytR AlgR family
CH54_1271	COG2223	nitrite transmembrane transporter activity
CH54_1272	COG0837	glucose binding
CH54_1274	COG0583	DNA-binding transcription factor activity
CH54_1275	COG0667	Aldo Keto reductase
CH54_1279	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH54_1284	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH54_129	COG2873	o-acetylhomoserine
CH54_1290	COG3530	Putative quorum-sensing-regulated virulence factor
CH54_1291	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH54_1294	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CH54_1295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_1296	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH54_1297	COG2190	(PTS) system
CH54_1298	COG2205	protein histidine kinase activity
CH54_1299	COG0745	RESPONSE REGULATOR receiver
CH54_13	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CH54_130	COG0702	epimerase
CH54_1302	COG4208	sulfate ABC transporter
CH54_1303	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH54_1304	COG4150	thiosulfate binding
CH54_1306	COG1737	Transcriptional regulator
CH54_1307	COG2731	YhcH YjgK YiaL family protein
CH54_131	COG1733	regulation of RNA biosynthetic process
CH54_1310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH54_1311	COG2837	iron assimilation
CH54_1313	COG3111	PFAM Bacterial OB fold (BOF) protein
CH54_1314	COG0456	acetyltransferase
CH54_1315	COG0408	coproporphyrinogen oxidase activity
CH54_1316	COG1671	Belongs to the UPF0178 family
CH54_1318	COG0494	nUDIX hydrolase
CH54_1321	COG3005	denitrification pathway
CH54_1322	COG3043	anaerobic respiration
CH54_1323	COG0243	molybdopterin cofactor binding
CH54_1324	COG3062	negative regulation of establishment of protein localization
CH54_1326	COG2197	response regulator
CH54_1328	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH54_1329	COG3842	ATPase activity
CH54_1331	COG1840	ABC-type Fe3 transport system, periplasmic component
CH54_1335	COG1393	Belongs to the ArsC family
CH54_1336	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH54_1337	COG1876	peptidase activity
CH54_1339	COG0400	carboxylic ester hydrolase activity
CH54_134	COG3755	Protein conserved in bacteria
CH54_1340	COG1444	tRNA N-acetyltransferase activity
CH54_1341	COG2707	UPF0756 membrane protein
CH54_1342	COG2321	neutral zinc metallopeptidase
CH54_1343	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CH54_1344	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH54_1345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH54_1346	COG2716	regulation of RNA biosynthetic process
CH54_1347	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH54_1348	COG0628	permease
CH54_1349	COG4783	chaperone-mediated protein folding
CH54_1350	COG1393	Belongs to the ArsC family
CH54_1351	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH54_1352	COG2233	PERMEase
CH54_1353	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CH54_1354	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CH54_1355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH54_1356	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH54_1359	COG0581	inorganic phosphate transmembrane transporter activity
CH54_136	COG4251	negative regulation of phosphorylation
CH54_136	COG3706	GGDEF domain
CH54_136	COG2203	Gaf domain
CH54_136	COG5001	Diguanylate cyclase
CH54_1360	COG0573	inorganic phosphate transmembrane transporter activity
CH54_1361	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH54_1362	COG0248	Ppx GppA phosphatase
CH54_1364	COG2239	Acts as a magnesium transporter
CH54_1365	COG3447	MASE1 domain protein
CH54_1365	COG5002	protein histidine kinase activity
CH54_1365	COG5001	Diguanylate cyclase
CH54_1366	COG0443	Heat shock 70 kDa protein
CH54_1368	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_1370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH54_1371	COG2205	protein histidine kinase activity
CH54_1372	COG0745	RESPONSE REGULATOR receiver
CH54_1373	COG3422	double-strand break repair
CH54_1375	COG1597	lipid kinase activity
CH54_1376	COG3730	PTS system glucitol sorbitol-specific
CH54_1379	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_138	COG1132	(ABC) transporter
CH54_1380	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_1381	COG1349	DNA-binding transcription factor activity
CH54_1385	COG0351	phosphomethylpyrimidine kinase
CH54_1393	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CH54_14	COG3070	regulator of competence-specific genes
CH54_1420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH54_143	COG2207	Transcriptional regulator
CH54_1439	COG0582	viral genome integration into host DNA
CH54_1440	COG0519	Catalyzes the synthesis of GMP from XMP
CH54_1440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CH54_1441	COG0516	GMP reductase activity
CH54_1441	COG0517	IMP dehydrogenase activity
CH54_1442	COG1570	exodeoxyribonuclease VII activity
CH54_1443	COG1645	bacterial-type flagellum-dependent swarming motility
CH54_1445	COG1160	GTP binding
CH54_1446	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH54_1447	COG2976	Protein conserved in bacteria
CH54_1448	COG0124	histidyl-tRNA synthetase
CH54_1452	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CH54_1455	COG4953	penicillin-binding protein 1C
CH54_1456	COG2373	Large extracellular alpha-helical protein
CH54_1457	COG3468	outer membrane autotransporter barrel domain protein
CH54_1460	COG2975	iron-sulfur cluster assembly
CH54_1461	COG0633	Ferredoxin
CH54_1462	COG0443	Heat shock 70 kDa protein
CH54_1463	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH54_1466	COG0822	iron-sulfur transferase activity
CH54_1468	COG1959	2 iron, 2 sulfur cluster binding
CH54_1469	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CH54_1470	COG0483	inositol monophosphate 1-phosphatase activity
CH54_1471	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH54_1472	COG3683	transport system, periplasmic component
CH54_1473	COG2814	Major facilitator Superfamily
CH54_1474	COG3711	transcriptional antiterminator
CH54_1475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CH54_1476	COG1017	nitric oxide dioxygenase activity
CH54_1476	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH54_1477	COG2188	Transcriptional regulator
CH54_1479	COG0347	Belongs to the P(II) protein family
CH54_1480	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH54_1480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH54_1481	COG2204	response regulator
CH54_1482	COG3170	Tfp pilus assembly protein FimV
CH54_1483	COG2205	protein histidine kinase activity
CH54_1485	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CH54_1486	COG0590	tRNA wobble adenosine to inosine editing
CH54_1488	COG0560	Phosphoserine phosphatase
CH54_1492	COG1737	Transcriptional regulator
CH54_1493	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH54_1494	COG2610	gluconate transmembrane transporter activity
CH54_1495	COG0736	holo-[acyl-carrier-protein] synthase activity
CH54_1496	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH54_1497	COG1381	Involved in DNA repair and RecF pathway recombination
CH54_1498	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CH54_15	COG1289	transmembrane transporter activity
CH54_150	COG1113	amino acid transport
CH54_1500	COG0681	Belongs to the peptidase S26 family
CH54_1501	COG0481	GTPase activity
CH54_1503	COG3086	response to oxidative stress
CH54_1505	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH54_1507	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH54_1508	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CH54_1509	COG0513	Belongs to the DEAD box helicase family
CH54_1510	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CH54_1511	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CH54_1512	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CH54_1513	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH54_1514	COG0497	DNA recombination
CH54_1515	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH54_1517	COG2867	negative regulation of translational initiation
CH54_1518	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CH54_1519	COG0582	viral genome integration into host DNA
CH54_152	COG1278	Cold shock
CH54_1522	COG1061	Type III restriction enzyme res subunit
CH54_1527	COG3311	Transcriptional regulator
CH54_1535	COG2003	Belongs to the UPF0758 family
CH54_1537	COG3394	polysaccharide catabolic process
CH54_1538	COG1917	Cupin 2, conserved barrel domain protein
CH54_1538	COG2169	Transcriptional regulator
CH54_1539	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH54_154	COG0768	penicillin binding
CH54_1540	COG2723	6-phospho-beta-galactosidase activity
CH54_1541	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH54_1542	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH54_1543	COG2133	pyrroloquinoline quinone binding
CH54_1544	COG0667	Aldo Keto reductase
CH54_1546	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH54_1547	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH54_1549	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH54_155	COG2226	methyltransferase
CH54_1550	COG4413	Urea transporter
CH54_1551	COG0829	nickel cation binding
CH54_1552	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH54_1554	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CH54_1555	COG0804	urea catabolic process
CH54_1556	COG0832	Belongs to the urease beta subunit family
CH54_1559	COG1124	(ABC) transporter
CH54_1561	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH54_1563	COG0747	negative chemotaxis
CH54_1567	COG1278	Cold shock
CH54_157	COG5002	protein histidine kinase activity
CH54_157	COG5001	Diguanylate cyclase
CH54_157	COG3447	MASE1 domain protein
CH54_1574	COG4575	ribosome binding
CH54_1576	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH54_1577	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH54_1578	COG1780	Probably involved in ribonucleotide reductase function
CH54_1580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH54_1582	COG4176	ABC-type proline glycine betaine transport system permease component
CH54_1583	COG2113	Glycine betaine
CH54_1585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH54_1586	COG0328	RNA-DNA hybrid ribonuclease activity
CH54_1587	COG2226	methyltransferase
CH54_1588	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH54_1589	COG0741	lytic transglycosylase activity
CH54_1589	COG1388	LysM domain
CH54_159	COG1971	Probably functions as a manganese efflux pump
CH54_1590	COG3021	interspecies interaction between organisms
CH54_1592	COG2814	Major facilitator Superfamily
CH54_1593	COG0583	DNA-binding transcription factor activity
CH54_1594	COG0656	L-ascorbic acid biosynthetic process
CH54_16	COG3304	Inner membrane component domain
CH54_160	COG4811	Protein of unknown function (DUF986)
CH54_1600	COG0542	response to heat
CH54_1602	COG0564	pseudouridine synthase activity
CH54_1603	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH54_1604	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH54_1605	COG0077	Prephenate dehydratase
CH54_1605	COG1605	Chorismate mutase
CH54_1606	COG0287	Prephenate dehydrogenase
CH54_1606	COG1605	Chorismate mutase
CH54_1607	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH54_1608	COG3279	Response regulator of the LytR AlgR family
CH54_1609	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH54_161	COG3716	PTS system mannose fructose sorbose family IID component
CH54_1610	COG3137	Salt-induced outer membrane protein
CH54_1611	COG0335	large ribosomal subunit rRNA binding
CH54_1612	COG0336	Belongs to the RNA methyltransferase TrmD family
CH54_1613	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CH54_1615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH54_1616	COG4137	Cytochrome C assembly protein
CH54_1617	COG4536	flavin adenine dinucleotide binding
CH54_1618	COG1854	S-ribosylhomocysteine lyase activity
CH54_1619	COG2918	glutathione biosynthetic process
CH54_162	COG3715	PTS system
CH54_1620	COG1238	metal cluster binding
CH54_1621	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH54_1626	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH54_1627	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH54_1628	COG2137	regulation of response to DNA damage stimulus
CH54_1629	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH54_163	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_163	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_1632	COG3381	protein complex oligomerization
CH54_1633	COG3302	dmso reductase anchor subunit
CH54_1634	COG0437	4 iron, 4 sulfur cluster binding
CH54_1635	COG0243	molybdopterin cofactor binding
CH54_1636	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH54_1636	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH54_1638	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH54_1639	COG4177	L-phenylalanine transmembrane transporter activity
CH54_164	COG1253	flavin adenine dinucleotide binding
CH54_1640	COG1137	ATPase activity
CH54_1641	COG0410	ABC transporter
CH54_1653	COG0640	Transcriptional regulator
CH54_1654	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CH54_1656	COG1858	cytochrome C peroxidase
CH54_1658	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_166	COG1760	l-serine dehydratase
CH54_1662	COG1538	Outer membrane efflux protein
CH54_1663	COG0577	efflux transmembrane transporter activity
CH54_1663	COG1136	(ABC) transporter
CH54_1664	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_167	COG0494	nUDIX hydrolase
CH54_1670	COG3539	Fimbrial protein
CH54_1671	COG3539	Fimbrial protein
CH54_1673	COG3121	Chaperone
CH54_1674	COG3188	usher protein
CH54_1679	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH54_1680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH54_1681	COG1388	LysM domain
CH54_1681	COG4942	peptidase
CH54_1682	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CH54_1683	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CH54_1684	COG0585	pseudouridine synthase activity
CH54_1685	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CH54_1687	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CH54_1689	COG0765	amino acid transport
CH54_169	COG3140	Belongs to the UPF0181 family
CH54_1692	COG0529	Catalyzes the synthesis of activated sulfate
CH54_1693	COG2895	sulfate adenylyltransferase (ATP) activity
CH54_1694	COG0175	sulfate reduction
CH54_1695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH54_1695	COG1648	precorrin-2 dehydrogenase activity
CH54_1696	COG2234	aminopeptidase activity
CH54_1697	COG0175	sulfate reduction
CH54_1698	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH54_1699	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CH54_17	COG0210	DNA helicase
CH54_170	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CH54_1700	COG0720	synthase
CH54_1701	COG0602	queuosine metabolic process
CH54_1707	COG0148	phosphopyruvate hydratase activity
CH54_1708	COG0504	CTP synthase activity
CH54_1709	COG3956	TIGRFAM MazG family protein
CH54_171	COG0513	Belongs to the DEAD box helicase family
CH54_1710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH54_1711	COG4999	Histidine kinase
CH54_1711	COG2205	protein histidine kinase activity
CH54_1711	COG3850	Histidine kinase
CH54_1711	COG3437	response regulator, receiver
CH54_1712	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH54_1713	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CH54_1714	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH54_1716	COG2860	membrane
CH54_1718	COG0316	Belongs to the HesB IscA family
CH54_172	COG3141	response to X-ray
CH54_1720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CH54_1721	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH54_1722	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH54_1723	COG1120	ATPase activity
CH54_1724	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH54_1725	COG1643	Atp-dependent helicase
CH54_1726	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CH54_1727	COG1489	DNA binding
CH54_1728	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH54_1730	COG0617	tRNA 3'-terminal CCA addition
CH54_1731	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH54_1732	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CH54_1733	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CH54_1734	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CH54_1735	COG0726	polysaccharide deacetylase
CH54_1736	COG0842	Transport permease protein
CH54_1737	COG1131	(ABC) transporter
CH54_1738	COG0288	reversible hydration of carbon dioxide
CH54_1739	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH54_1741	COG2132	Multicopper oxidase
CH54_1743	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CH54_1744	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CH54_1746	COG3210	domain, Protein
CH54_1747	COG3112	Uncharacterised protein family (UPF0231)
CH54_1748	COG0697	spore germination
CH54_175	COG1770	oligopeptidase
CH54_1750	COG1049	propionate catabolic process, 2-methylcitrate cycle
CH54_1752	COG4977	sequence-specific DNA binding
CH54_1754	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH54_1755	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH54_1756	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH54_1757	COG2186	Transcriptional regulator
CH54_1758	COG1113	amino acid transport
CH54_1759	COG3725	Membrane protein required for beta-lactamase induction
CH54_176	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH54_1762	COG4969	Belongs to the N-Me-Phe pilin family
CH54_1763	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH54_1764	COG1459	type II secretion system
CH54_1765	COG0516	GMP reductase activity
CH54_1766	COG0237	dephospho-CoA kinase activity
CH54_1768	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CH54_1769	COG0494	nUDIX hydrolase
CH54_1770	COG0653	protein targeting
CH54_1774	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH54_1775	COG0849	cell division
CH54_1776	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH54_1778	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH54_1779	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CH54_1780	COG0772	Belongs to the SEDS family
CH54_1783	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH54_1784	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH54_1785	COG0768	penicillin binding
CH54_1786	COG3116	cell division
CH54_1787	COG0275	rRNA processing
CH54_1788	COG2001	Belongs to the MraZ family
CH54_179	COG1528	Iron-storage protein
CH54_1790	COG1609	Transcriptional regulator
CH54_1792	COG0028	Belongs to the TPP enzyme family
CH54_1793	COG1022	Amp-dependent synthetase and ligase
CH54_1796	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CH54_1797	COG0473	3-isopropylmalate dehydrogenase activity
CH54_1798	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CH54_180	COG2372	response to copper ion
CH54_1801	COG3033	Beta-eliminating lyase
CH54_1802	COG2814	Major facilitator Superfamily
CH54_1804	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH54_1805	COG4533	DNA binding
CH54_1806	COG4143	(ABC) transporter
CH54_1807	COG1178	ABC-type Fe3 transport system permease component
CH54_1809	COG0586	Pfam SNARE associated Golgi protein
CH54_181	COG1276	copper resistance
CH54_1810	COG0417	DNA replication proofreading
CH54_1811	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CH54_1812	COG0564	pseudouridine synthase activity
CH54_1814	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH54_1815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH54_1816	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CH54_1818	COG2967	ApaG domain
CH54_1819	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH54_1822	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH54_1824	COG2966	Psort location CytoplasmicMembrane, score
CH54_1825	COG1280	lysine exporter protein (LysE YggA)
CH54_1826	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH54_1827	COG0505	Belongs to the CarA family
CH54_1828	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CH54_1829	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CH54_1830	COG1047	Peptidyl-prolyl cis-trans
CH54_1831	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CH54_1832	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CH54_1833	COG0196	riboflavin kinase activity
CH54_1835	COG0583	DNA-binding transcription factor activity
CH54_1836	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH54_1837	COG0484	heat shock protein binding
CH54_1839	COG1584	GPR1 FUN34 yaaH family protein
CH54_1842	COG0477	Major facilitator Superfamily
CH54_1843	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH54_1844	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH54_1845	COG3022	response to hydroperoxide
CH54_1847	COG0083	homoserine kinase activity
CH54_1849	COG0745	RESPONSE REGULATOR receiver
CH54_185	COG2026	Addiction module toxin, RelE StbE family
CH54_1850	COG3045	CreA protein
CH54_1852	COG2207	Transcriptional regulator
CH54_1852	COG3708	Transcriptional regulator
CH54_1853	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CH54_1854	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH54_1855	COG0741	lytic transglycosylase activity
CH54_1856	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH54_1857	COG0488	(ABC) transporter
CH54_1859	COG0604	alcohol dehydrogenase
CH54_186	COG3077	Addiction module antitoxin, RelB DinJ family
CH54_1863	COG0560	Phosphoserine phosphatase
CH54_1864	COG3726	membrane protein affecting hemolysin expression
CH54_1866	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH54_1867	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CH54_1868	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH54_1869	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH54_1870	COG0084	hydrolase, TatD family'
CH54_1871	COG4667	esterase of the alpha-beta hydrolase superfamily
CH54_1873	COG2823	Periplasmic or secreted lipoprotein
CH54_1874	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CH54_1875	COG0456	acetyltransferase
CH54_1876	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH54_1877	COG2813	Specifically methylates the guanine in position
CH54_1878	COG0667	Aldo Keto reductase
CH54_1879	COG0583	DNA-binding transcription factor activity
CH54_1883	COG3706	GGDEF domain
CH54_1884	COG3284	Transcriptional regulator
CH54_1889	COG2192	nodulation
CH54_189	COG1187	pseudouridine synthase activity
CH54_1891	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH54_1891	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CH54_1891	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_1892	COG1461	Dihydroxyacetone kinase
CH54_1893	COG2376	Dihydroxyacetone kinase
CH54_1895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH54_1896	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_1897	COG2235	arginine
CH54_190	COG0786	glutamate:sodium symporter activity
CH54_1900	COG0859	PFAM glycosyl transferase family 9
CH54_1901	COG1070	Carbohydrate kinase
CH54_1902	COG2390	Transcriptional regulator
CH54_1903	COG1129	ABC transporter
CH54_1904	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH54_1905	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH54_1906	COG1879	ABC-type sugar transport system periplasmic component
CH54_1907	COG1830	Aldolase
CH54_1908	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH54_1916	COG2831	hemolysin activation secretion protein
CH54_1917	COG3210	domain, Protein
CH54_1920	COG3210	domain, Protein
CH54_1925	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CH54_1929	COG0795	lipopolysaccharide-transporting ATPase activity
CH54_1930	COG0795	lipopolysaccharide-transporting ATPase activity
CH54_1931	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CH54_1932	COG2927	DNA polymerase III (CHI subunit)
CH54_1935	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH54_1937	COG2731	YhcH YjgK YiaL family protein
CH54_1939	COG0601	transmembrane transport
CH54_1941	COG0444	Belongs to the ABC transporter superfamily
CH54_1942	COG4608	Belongs to the ABC transporter superfamily
CH54_1945	COG2188	Transcriptional regulator
CH54_1946	COG3624	Phosphonate C-P lyase system protein PhnG
CH54_1947	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CH54_1948	COG3626	phosphonate metabolism
CH54_1949	COG3627	carbon phosphorus lyase activity
CH54_1950	COG4107	phosphonate C-P lyase system protein PhnK
CH54_1951	COG4778	phosphonate C-P lyase system protein PhnL
CH54_1952	COG3454	Phosphonate metabolism
CH54_1953	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CH54_1954	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CH54_1955	COG0702	epimerase
CH54_1956	COG3787	Belongs to the UPF0306 family
CH54_1958	COG3842	ATPase activity
CH54_1959	COG0395	ABC-type sugar transport system, permease component
CH54_196	COG0668	transmembrane transport
CH54_1961	COG1653	transport
CH54_1964	COG1982	Orn Lys Arg decarboxylase major
CH54_1965	COG0531	amino acid
CH54_1966	COG3153	acetyltransferase
CH54_1967	COG2827	Endonuclease containing a URI domain
CH54_1971	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH54_1972	COG0513	Belongs to the DEAD box helicase family
CH54_1974	COG1185	polyribonucleotide nucleotidyltransferase activity
CH54_1976	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CH54_1977	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CH54_1978	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CH54_1979	COG0195	Participates in both transcription termination and antitermination
CH54_1980	COG0779	Required for maturation of 30S ribosomal subunits
CH54_1983	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH54_1985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH54_1986	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CH54_1987	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CH54_1988	COG1534	Rna-binding protein
CH54_1989	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH54_1990	COG2027	D-alanyl-D-alanine carboxypeptidase
CH54_1991	COG0745	RESPONSE REGULATOR receiver
CH54_1992	COG0642	Histidine kinase
CH54_1993	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CH54_1994	COG0697	spore germination
CH54_1997	COG0142	geranyltranstransferase activity
CH54_1999	COG3423	Transcriptional regulator
CH54_2	COG0488	(ABC) transporter
CH54_20	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CH54_2000	COG0039	L-malate dehydrogenase activity
CH54_2001	COG1438	arginine binding
CH54_2004	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH54_2005	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CH54_2006	COG0840	transmembrane signaling receptor activity
CH54_2007	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH54_2008	COG2105	PFAM AIG2 family protein
CH54_2009	COG2911	Protein conserved in bacteria
CH54_2010	COG0729	surface antigen
CH54_2011	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH54_2012	COG1253	flavin adenine dinucleotide binding
CH54_2014	COG1218	3'(2'),5'-bisphosphate nucleotidase
CH54_2015	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH54_2016	COG0737	Belongs to the 5'-nucleotidase family
CH54_2019	COG0545	Peptidyl-prolyl cis-trans isomerase
CH54_2020	COG3061	Opacity-associated protein A
CH54_2022	COG0359	binds to the 23S rRNA
CH54_2023	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH54_2024	COG2965	DNA replication, synthesis of RNA primer
CH54_2025	COG0360	Binds together with S18 to 16S ribosomal RNA
CH54_2027	COG1073	alpha beta
CH54_2028	COG3650	response to hydrogen peroxide
CH54_2029	COG1960	acyl-CoA dehydrogenase activity
CH54_2030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH54_2031	COG0557	exoribonuclease II activity
CH54_2032	COG1959	2 iron, 2 sulfur cluster binding
CH54_2033	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CH54_2034	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH54_2035	COG0330	HflC and HflK could
CH54_2036	COG0330	HflC and HflK could
CH54_2037	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH54_2039	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CH54_204	COG4251	negative regulation of phosphorylation
CH54_204	COG2203	Gaf domain
CH54_204	COG3706	GGDEF domain
CH54_204	COG5001	Diguanylate cyclase
CH54_2040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CH54_2041	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH54_2042	COG0802	atpase or kinase
CH54_2043	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH54_2043	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH54_2044	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH54_2048	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH54_2049	COG1162	GTPase activity
CH54_2050	COG0688	phosphatidylethanolamine metabolic process
CH54_2051	COG1511	domain protein
CH54_2051	COG3264	Mechanosensitive ion channel
CH54_2052	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CH54_2053	COG1053	succinate dehydrogenase
CH54_2054	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH54_2055	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH54_2056	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH54_2058	COG2076	Multidrug Resistance protein
CH54_2060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH54_2063	COG0459	protein refolding
CH54_2064	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CH54_2067	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH54_2069	COG4232	protein-disulfide reductase activity
CH54_2070	COG3383	formate dehydrogenase (NAD+) activity
CH54_2071	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH54_2072	COG0493	'glutamate synthase
CH54_2072	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH54_2074	COG2271	Major facilitator Superfamily
CH54_2075	COG2721	sulfolactate sulfo-lyase activity
CH54_2076	COG3835	regulator
CH54_2077	COG1929	Belongs to the glycerate kinase type-1 family
CH54_2078	COG2084	Dehydrogenase
CH54_2080	COG1309	transcriptional regulator
CH54_2082	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH54_2087	COG2826	transposase and inactivated derivatives, IS30 family
CH54_2089	COG0210	DNA helicase
CH54_2090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH54_21	COG1832	CoA-binding protein
CH54_2103	COG3657	addiction module killer protein
CH54_211	COG2814	Major facilitator Superfamily
CH54_2119	COG3547	Transposase (IS116 IS110 IS902 family)
CH54_213	COG3008	intermembrane lipid transfer
CH54_214	COG2995	paraquat-inducible protein a
CH54_215	COG1956	GAF domain-containing protein
CH54_2156	COG0305	Participates in initiation and elongation during chromosome replication
CH54_2161	COG3720	iron ion transport
CH54_2162	COG4558	Periplasmic binding protein
CH54_2163	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH54_2164	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH54_2165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH54_2167	COG4774	siderophore transport
CH54_2168	COG3264	Mechanosensitive ion channel
CH54_2168	COG1511	domain protein
CH54_2169	COG0425	Belongs to the sulfur carrier protein TusA family
CH54_217	COG0793	Belongs to the peptidase S41A family
CH54_2170	COG2391	methyltransferase activity
CH54_218	COG0501	Belongs to the peptidase M48B family
CH54_22	COG3785	DNA binding
CH54_220	COG2814	Major facilitator Superfamily
CH54_2203	COG1301	dicarboxylic acid transport
CH54_2204	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CH54_2205	COG3162	membrane
CH54_2206	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH54_221	COG0823	Involved in the tonB-independent uptake of proteins
CH54_2213	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH54_2214	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH54_2215	COG0009	L-threonylcarbamoyladenylate synthase
CH54_2216	COG0551	DNA topoisomerase type I activity
CH54_2218	COG0758	DNA mediated transformation
CH54_2219	COG0242	peptide deformylase activity
CH54_2220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH54_2221	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CH54_2221	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH54_2222	COG0569	domain protein
CH54_2223	COG1970	mechanosensitive ion channel activity
CH54_2224	COG3036	rescue of stalled ribosome
CH54_2225	COG0789	Transcriptional regulator
CH54_2227	COG0203	ribosomal protein L17
CH54_2228	COG0202	RNA polymerase activity
CH54_2229	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH54_223	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH54_2230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CH54_2231	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CH54_2232	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH54_2233	COG0201	protein transport
CH54_2234	COG0200	Binds to the 23S rRNA
CH54_2235	COG1841	ribosomal large subunit assembly
CH54_2237	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CH54_2238	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CH54_2240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CH54_2242	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CH54_2243	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH54_2244	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH54_2245	COG0255	Belongs to the universal ribosomal protein uL29 family
CH54_2246	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH54_2247	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CH54_2248	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CH54_2249	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH54_225	COG1988	membrane-bound metal-dependent
CH54_2250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CH54_2251	COG0089	rRNA binding
CH54_2253	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CH54_2254	COG0051	transcription antitermination factor activity, RNA binding
CH54_2257	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CH54_2259	COG0049	tRNA binding
CH54_226	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH54_2260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH54_2261	COG2168	tRNA wobble position uridine thiolation
CH54_2262	COG2923	Belongs to the DsrF TusC family
CH54_2263	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH54_2264	COG2964	Protein conserved in bacteria
CH54_2265	COG0545	Peptidyl-prolyl cis-trans isomerase
CH54_2266	COG2900	Belongs to the SlyX family
CH54_2267	COG1047	Peptidyl-prolyl cis-trans
CH54_2268	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH54_227	COG1653	transport
CH54_2270	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH54_2271	COG0488	(ABC) transporter
CH54_2273	COG2175	clavaminate synthase activity
CH54_2275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH54_2277	COG4521	taurine ABC transporter
CH54_228	COG3842	ATPase activity
CH54_2280	COG0429	hydrolase of the alpha beta-hydrolase fold
CH54_2281	COG3089	Belongs to the UPF0270 family
CH54_2282	COG3954	Phosphoribulokinase
CH54_2283	COG1765	OsmC-like protein
CH54_2285	COG1289	transmembrane transporter activity
CH54_2289	COG0433	COG0433 Predicted ATPase
CH54_229	COG0395	ABC-type sugar transport system, permease component
CH54_2290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH54_2291	COG1486	melibiose metabolic process
CH54_2292	COG1609	Transcriptional regulator
CH54_2293	COG0738	Major facilitator superfamily
CH54_2294	COG0402	S-adenosylhomocysteine deaminase activity
CH54_2296	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH54_2297	COG2146	nitrite reductase [NAD(P)H] activity
CH54_2299	COG1648	precorrin-2 dehydrogenase activity
CH54_2299	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH54_23	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH54_230	COG1175	transmembrane transport
CH54_2300	COG0180	Tryptophanyl-tRNA synthetase
CH54_2302	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH54_2306	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH54_2307	COG4796	Type ii and iii secretion system protein
CH54_2312	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH54_2313	COG0494	nUDIX hydrolase
CH54_2315	COG1011	Hydrolase
CH54_2316	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH54_2318	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CH54_232	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_2320	COG0745	RESPONSE REGULATOR receiver
CH54_2321	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH54_2326	COG2183	response to ionizing radiation
CH54_2327	COG1918	ferrous iron import across plasma membrane
CH54_2328	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CH54_233	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CH54_2331	COG0596	Alpha beta hydrolase
CH54_2333	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CH54_2333	COG0316	Belongs to the HesB IscA family
CH54_2334	COG1640	4-alpha-glucanotransferase
CH54_2335	COG0058	SHG alpha-glucan phosphorylase activity
CH54_2336	COG2909	trisaccharide binding
CH54_2338	COG0705	Rhomboid family
CH54_2339	COG1349	DNA-binding transcription factor activity
CH54_234	COG1917	Cupin 2, conserved barrel domain protein
CH54_2342	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH54_2343	COG0058	SHG alpha-glucan phosphorylase activity
CH54_2344	COG0297	glycogen (starch) synthase activity
CH54_2346	COG1523	belongs to the glycosyl hydrolase 13 family
CH54_2347	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CH54_2348	COG3275	phosphorelay sensor kinase activity
CH54_235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH54_2353	COG0463	Glycosyl transferase, family 2
CH54_2356	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH54_2357	COG2095	MarC family integral membrane protein
CH54_2358	COG3265	gluconokinase activity
CH54_2359	COG2610	gluconate transmembrane transporter activity
CH54_2360	COG1609	Transcriptional regulator
CH54_2361	COG1741	Belongs to the pirin family
CH54_2362	COG1247	-acetyltransferase
CH54_2363	COG1082	Xylose isomerase domain protein TIM barrel
CH54_2364	COG1082	Xylose isomerase domain protein TIM barrel
CH54_2365	COG0673	inositol 2-dehydrogenase activity
CH54_2366	COG3962	Belongs to the TPP enzyme family
CH54_2367	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH54_2369	COG3718	enzyme involved in inositol metabolism
CH54_2377	COG3121	Chaperone
CH54_238	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH54_2382	COG2081	HI0933 family
CH54_2383	COG0306	phosphate transporter
CH54_2385	COG0589	response to stress
CH54_2389	COG0742	ribosomal rna small subunit methyltransferase
CH54_239	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH54_2391	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH54_2392	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH54_2394	COG1295	ribonuclease BN
CH54_2395	COG2134	cdp-diacylglycerol pyrophosphatase
CH54_2396	COG2982	Protein involved in outer membrane biogenesis
CH54_2397	COG2200	EAL domain
CH54_2398	COG1942	4-Oxalocrotonate Tautomerase
CH54_2399	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH54_240	COG1121	(ABC) transporter
CH54_2400	COG0612	Peptidase, M16
CH54_2401	COG1301	dicarboxylic acid transport
CH54_2403	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH54_2404	COG2200	EAL domain
CH54_2404	COG2199	diguanylate cyclase activity
CH54_2405	COG0457	Tetratricopeptide repeat
CH54_2405	COG3118	belongs to the thioredoxin family
CH54_2406	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CH54_2407	COG1215	transferase activity, transferring glycosyl groups
CH54_2408	COG1215	transferase activity, transferring glycosyl groups
CH54_2409	COG1192	Involved in chromosome partitioning
CH54_241	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH54_2413	COG2194	sulfuric ester hydrolase activity
CH54_2414	COG4608	Belongs to the ABC transporter superfamily
CH54_2415	COG0444	Belongs to the ABC transporter superfamily
CH54_2416	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH54_2417	COG0601	transmembrane transport
CH54_2418	COG0747	negative chemotaxis
CH54_2419	COG3210	domain, Protein
CH54_2420	COG2831	hemolysin activation secretion protein
CH54_2424	COG2271	Major facilitator Superfamily
CH54_2425	COG3851	Histidine kinase
CH54_2426	COG2197	response regulator
CH54_2427	COG2194	sulfuric ester hydrolase activity
CH54_2428	COG1764	response to oxidative stress
CH54_2432	COG2986	histidine ammonia-lyase
CH54_2433	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CH54_2438	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_2438	COG2205	protein histidine kinase activity
CH54_2440	COG1609	Transcriptional regulator
CH54_2440	COG2207	Transcriptional regulator
CH54_2441	COG4214	carbohydrate transport
CH54_2443	COG4213	ABC transporter substrate-binding protein
CH54_2444	COG2115	Belongs to the xylose isomerase family
CH54_2445	COG1070	Carbohydrate kinase
CH54_2446	COG3121	Chaperone
CH54_2447	COG1335	isochorismatase
CH54_2448	COG3274	enterobacterial common antigen metabolic process
CH54_2450	COG3550	peptidyl-serine autophosphorylation
CH54_2454	COG3276	selenocysteine insertion sequence binding
CH54_2455	COG1921	L-seryl-tRNASec selenium transferase activity
CH54_2456	COG3058	Necessary for formate dehydrogenase activity
CH54_2457	COG2864	formate dehydrogenase
CH54_2458	COG0437	4 iron, 4 sulfur cluster binding
CH54_2459	COG0243	molybdopterin cofactor binding
CH54_2459	COG3383	formate dehydrogenase (NAD+) activity
CH54_2460	COG0243	molybdopterin cofactor binding
CH54_2460	COG3383	formate dehydrogenase (NAD+) activity
CH54_2461	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CH54_2462	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH54_2463	COG0840	transmembrane signaling receptor activity
CH54_2465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH54_2466	COG3722	fumarate hydratase activity
CH54_2468	COG0246	Mannitol dehydrogenase
CH54_2469	COG2213	PTS system mannitol-specific
CH54_2469	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_2471	COG0751	glycine-tRNA ligase activity
CH54_2472	COG0752	glycyl-tRNA synthetase alpha subunit
CH54_2475	COG2818	Glycosylase
CH54_2476	COG0456	acetyltransferase
CH54_248	COG1811	Na channel or pump
CH54_2481	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH54_2482	COG0366	Alpha amylase catalytic
CH54_2483	COG3977	Valine--pyruvate aminotransferase
CH54_2484	COG2985	domain, Protein
CH54_2484	COG0569	domain protein
CH54_2487	COG5645	(Lipo)protein
CH54_2488	COG0823	Involved in the tonB-independent uptake of proteins
CH54_249	COG3328	transposase activity
CH54_2491	COG2423	ornithine cyclodeaminase activity
CH54_2492	COG0561	phosphatase activity
CH54_2493	COG0187	DNA topoisomerase II activity
CH54_2494	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH54_2495	COG0592	DNA-directed DNA polymerase activity
CH54_2496	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH54_2497	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH54_2498	COG0594	ribonuclease P activity
CH54_25	COG1254	Belongs to the acylphosphatase family
CH54_2500	COG0706	membrane insertase activity
CH54_2501	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CH54_2502	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CH54_2505	COG2011	ABC-type metal ion transport system permease component
CH54_2506	COG0840	transmembrane signaling receptor activity
CH54_2507	COG0431	NADPH-dependent FMN reductase
CH54_2508	COG4191	Histidine kinase
CH54_2509	COG4566	intracellular signal transduction
CH54_2511	COG2252	PERMEase
CH54_2512	COG0765	amino acid transport
CH54_2513	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH54_2514	COG0765	amino acid transport
CH54_2515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_2517	COG0704	Plays a role in the regulation of phosphate uptake
CH54_2519	COG0581	inorganic phosphate transmembrane transporter activity
CH54_252	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CH54_2520	COG0573	inorganic phosphate transmembrane transporter activity
CH54_2521	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH54_2522	COG0659	secondary active sulfate transmembrane transporter activity
CH54_2523	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CH54_2524	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CH54_2525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CH54_2526	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CH54_2528	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CH54_2529	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CH54_253	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CH54_2530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CH54_2532	COG0356	it plays a direct role in the translocation of protons across the membrane
CH54_2533	COG3312	ion transport
CH54_2534	COG0357	Ribosomal RNA small subunit methyltransferase G
CH54_2535	COG0445	tRNA wobble uridine modification
CH54_2536	COG0716	FMN binding
CH54_2537	COG1522	sequence-specific DNA binding
CH54_2538	COG2502	aspartate--ammonia ligase
CH54_254	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CH54_2540	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CH54_2541	COG0714	Associated with various cellular activities
CH54_2542	COG3158	transport of potassium into the cell
CH54_2543	COG1869	D-ribose catabolic process
CH54_2545	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH54_2546	COG1879	ABC-type sugar transport system periplasmic component
CH54_2547	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH54_2548	COG0477	Major facilitator Superfamily
CH54_2549	COG1609	Transcriptional regulator
CH54_2550	COG2186	Transcriptional regulator
CH54_2555	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH54_2557	COG3084	Protein conserved in bacteria
CH54_2558	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH54_2559	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH54_2560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH54_2560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH54_2561	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CH54_2562	COG3078	GTPase activator activity
CH54_2563	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH54_2565	COG3852	Histidine kinase
CH54_2566	COG0174	glutamine synthetase
CH54_2568	COG1011	Hydrolase
CH54_2569	COG1295	ribonuclease BN
CH54_2570	COG1490	D-aminoacyl-tRNA deacylase activity
CH54_2571	COG0456	acetyltransferase
CH54_2572	COG3423	Transcriptional regulator
CH54_2575	COG2982	Protein involved in outer membrane biogenesis
CH54_2576	COG2233	PERMEase
CH54_2577	COG0786	glutamate:sodium symporter activity
CH54_2578	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH54_2579	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH54_258	COG0776	regulation of translation
CH54_2580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH54_2581	COG1758	RNA polymerase activity
CH54_2583	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH54_2584	COG2860	membrane
CH54_2587	COG1024	Enoyl-CoA hydratase
CH54_2588	COG5001	Diguanylate cyclase
CH54_259	COG3122	Protein conserved in bacteria
CH54_2594	COG1561	YicC-like family, N-terminal region
CH54_26	COG2920	part of a sulfur-relay system
CH54_261	COG4139	cobalamin transport
CH54_262	COG0386	Belongs to the glutathione peroxidase family
CH54_2622	COG4695	Portal protein
CH54_263	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH54_2630	COG5002	protein histidine kinase activity
CH54_2630	COG2176	DNA-directed DNA polymerase activity
CH54_264	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH54_2640	COG4974	Belongs to the 'phage' integrase family
CH54_2642	COG1309	transcriptional regulator
CH54_2643	COG0756	dUTP diphosphatase activity
CH54_2644	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH54_2645	COG2003	Belongs to the UPF0758 family
CH54_2646	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CH54_2647	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH54_2648	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CH54_265	COG0463	Glycosyl transferase, family 2
CH54_2651	COG1519	Transferase
CH54_2652	COG0859	PFAM glycosyl transferase family 9
CH54_2653	COG0859	PFAM glycosyl transferase family 9
CH54_2654	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH54_2655	COG0156	8-amino-7-oxononanoate synthase activity
CH54_2656	COG1063	alcohol dehydrogenase
CH54_2657	COG2861	carbohydrate metabolic process
CH54_2658	COG4942	peptidase
CH54_2659	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CH54_266	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH54_266	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH54_2660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH54_2661	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH54_2663	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CH54_2664	COG1045	serine acetyltransferase
CH54_2665	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH54_2666	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH54_2666	COG2169	Transcriptional regulator
CH54_2667	COG2205	protein histidine kinase activity
CH54_2668	COG0745	RESPONSE REGULATOR receiver
CH54_2669	COG3678	ATP-independent chaperone mediated protein folding
CH54_267	COG0726	polysaccharide deacetylase
CH54_2670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CH54_2672	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH54_2676	COG3152	Membrane
CH54_2678	COG2814	Major facilitator Superfamily
CH54_2679	COG1494	fructose-1,6-bisphosphatase
CH54_268	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CH54_2680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH54_2681	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH54_2682	COG3074	FtsZ-dependent cytokinesis
CH54_2683	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CH54_2684	COG1575	Belongs to the MenA family. Type 1 subfamily
CH54_2685	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CH54_2686	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CH54_2687	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH54_2688	COG1609	Transcriptional regulator
CH54_2689	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH54_269	COG2076	Multidrug Resistance protein
CH54_2690	COG0254	rRNA binding
CH54_2691	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CH54_2692	COG0626	cystathionine gamma-synthase activity
CH54_2693	COG0527	aspartate kinase activity
CH54_2693	COG0460	homoserine dehydrogenase
CH54_2695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CH54_2697	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CH54_2698	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH54_2699	COG0165	Argininosuccinate lyase
CH54_270	COG2076	Multidrug Resistance protein
CH54_2708	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH54_2709	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH54_2709	COG0678	peroxiredoxin activity
CH54_271	COG0791	NLP P60 protein
CH54_2710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH54_2714	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH54_2716	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CH54_272	COG0095	Lipoate-protein ligase
CH54_2724	COG0583	DNA-binding transcription factor activity
CH54_2725	COG3085	chromosome segregation
CH54_2728	COG3978	acetolactate synthase activity
CH54_2729	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH54_2730	COG0129	dihydroxy-acid dehydratase activity
CH54_2731	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH54_2732	COG0583	DNA-binding transcription factor activity
CH54_2733	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CH54_2739	COG3121	Chaperone
CH54_274	COG4558	Periplasmic binding protein
CH54_2742	COG3121	Chaperone
CH54_2744	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH54_2746	COG0248	Ppx GppA phosphatase
CH54_2748	COG3118	belongs to the thioredoxin family
CH54_2749	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH54_275	COG3720	iron ion transport
CH54_2750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH54_2751	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH54_2752	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH54_2753	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH54_2754	COG1088	dTDP-glucose 4,6-dehydratase activity
CH54_2755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH54_2756	COG0456	acetyltransferase
CH54_2757	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH54_2758	COG2244	polysaccharide biosynthetic process
CH54_2759	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH54_2762	COG1113	amino acid transport
CH54_2769	COG3071	HemY protein
CH54_2770	COG2959	enzyme of heme biosynthesis
CH54_2771	COG1587	Uroporphyrinogen-III synthase
CH54_2772	COG0181	hydroxymethylbilane synthase activity
CH54_2773	COG3072	Adenylate cyclase
CH54_2774	COG1965	Belongs to the frataxin family
CH54_2775	COG5567	small periplasmic lipoprotein
CH54_2776	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CH54_2777	COG3159	Protein conserved in bacteria
CH54_2778	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH54_2779	COG1011	Hydrolase
CH54_278	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CH54_2780	COG0210	DNA helicase
CH54_2782	COG5441	Belongs to the UPF0261 family
CH54_2783	COG5564	TIM-barrel signal transduction protein
CH54_2785	COG0598	Magnesium transport protein CorA
CH54_2787	COG2050	protein possibly involved in aromatic compounds catabolism
CH54_2788	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CH54_2789	COG0514	ATP-dependent DNA helicase (RecQ)
CH54_279	COG0574	Belongs to the PEP-utilizing enzyme family
CH54_279	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH54_2790	COG1280	lysine exporter protein (LysE YggA)
CH54_2791	COG1280	lysine exporter protein (LysE YggA)
CH54_2792	COG2267	carboxylic ester hydrolase activity
CH54_2793	COG0561	phosphatase activity
CH54_2794	COG0584	glycerophosphoryl diester phosphodiesterase
CH54_2795	COG2271	Major facilitator Superfamily
CH54_2796	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH54_2798	COG0247	lactate metabolic process
CH54_28	COG1518	maintenance of DNA repeat elements
CH54_280	COG0628	permease
CH54_2800	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH54_2801	COG0425	Belongs to the sulfur carrier protein TusA family
CH54_2803	COG3714	YhhN family
CH54_2806	COG3776	membrane
CH54_2807	COG0742	ribosomal rna small subunit methyltransferase
CH54_2808	COG0552	protein localization to endoplasmic reticulum
CH54_2809	COG2884	Cell division ATP-binding protein ftsE
CH54_281	COG0247	lactate metabolic process
CH54_281	COG0277	FAD linked oxidase domain protein
CH54_2810	COG2177	Part of the ABC transporter FtsEX involved in
CH54_2814	COG0683	leucine binding
CH54_2815	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH54_2816	COG4177	L-phenylalanine transmembrane transporter activity
CH54_2817	COG0411	ABC transporter
CH54_2818	COG0410	ABC transporter
CH54_282	COG2050	protein possibly involved in aromatic compounds catabolism
CH54_2825	COG1653	transport
CH54_2826	COG1175	transmembrane transport
CH54_2827	COG0395	ABC-type sugar transport system, permease component
CH54_2828	COG3842	ATPase activity
CH54_2829	COG0584	glycerophosphoryl diester phosphodiesterase
CH54_283	COG0316	Belongs to the HesB IscA family
CH54_2830	COG0679	Auxin Efflux Carrier
CH54_2831	COG0583	DNA-binding transcription factor activity
CH54_2833	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CH54_2834	COG0412	Dienelactone hydrolase
CH54_2835	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CH54_2837	COG1966	Carbon starvation protein
CH54_2838	COG0586	Pfam SNARE associated Golgi protein
CH54_2839	COG1322	Protein conserved in bacteria
CH54_284	COG0719	Fe-S assembly protein
CH54_2840	COG2226	methyltransferase
CH54_2842	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CH54_2843	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH54_2844	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH54_2845	COG0805	protein transport
CH54_2849	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CH54_285	COG0396	ATPase activity
CH54_2851	COG0183	Belongs to the thiolase family
CH54_2852	COG1024	Enoyl-CoA hydratase
CH54_2852	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH54_2854	COG0006	proline dipeptidase activity
CH54_2855	COG1739	Uncharacterized protein family UPF0029
CH54_2856	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH54_286	COG0719	Fe-S assembly protein
CH54_2864	COG1072	(Pantothenic acid kinase))
CH54_2873	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CH54_2874	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH54_2875	COG0250	Participates in transcription elongation, termination and antitermination
CH54_2876	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CH54_2877	COG0081	regulation of translation
CH54_2878	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CH54_288	COG2166	iron-sulfur cluster assembly
CH54_2880	COG0085	RNA polymerase activity
CH54_2882	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CH54_2883	COG2022	thiamine diphosphate biosynthetic process
CH54_2884	COG2104	thiamine diphosphate biosynthetic process
CH54_2885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH54_2887	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CH54_2888	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CH54_2889	COG2816	NAD+ diphosphatase activity
CH54_289	COG1388	LysM domain
CH54_289	COG1376	ErfK ybiS ycfS ynhG family protein
CH54_2890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CH54_2891	COG1515	deoxyribonuclease V activity
CH54_2892	COG3068	Protein conserved in bacteria
CH54_2895	COG0151	Belongs to the GarS family
CH54_2896	COG0138	bifunctional purine biosynthesis protein purh
CH54_29	COG1203	CRISPR-associated helicase, Cas3
CH54_290	COG4238	major outer membrane lipoprotein
CH54_2904	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CH54_2905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH54_2906	COG2224	Isocitrate lyase
CH54_2907	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CH54_2908	COG1414	Transcriptional regulator
CH54_2913	COG0527	aspartate kinase activity
CH54_2916	COG3223	Belongs to the PsiE family
CH54_2917	COG3833	ABC-type maltose transport systems, permease component
CH54_2918	COG1175	transmembrane transport
CH54_2919	COG2182	Extracellular solute-binding protein
CH54_2924	COG3161	chorismate lyase activity
CH54_2925	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CH54_2926	COG2937	Belongs to the GPAT DAPAT family
CH54_2927	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH54_2928	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CH54_2929	COG3237	CsbD-like
CH54_2930	COG0735	belongs to the Fur family
CH54_2931	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH54_2935	COG0305	Participates in initiation and elongation during chromosome replication
CH54_2936	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH54_2937	COG1448	Aminotransferase
CH54_2938	COG2315	Protein conserved in bacteria
CH54_2939	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH54_2945	COG2252	PERMEase
CH54_2946	COG0025	NhaP-type Na H and K H
CH54_2947	COG0583	DNA-binding transcription factor activity
CH54_2948	COG1380	Effector of murein hydrolase LrgA
CH54_295	COG0534	Mate efflux family protein
CH54_2951	COG1560	Kdo2-lipid A biosynthetic process
CH54_2952	COG0471	metal ion transport
CH54_2954	COG1278	Cold shock
CH54_2955	COG1278	Cold shock
CH54_2956	COG3133	Outer membrane lipoprotein
CH54_2957	COG3706	GGDEF domain
CH54_2958	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH54_2959	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH54_296	COG0307	riboflavin synthase, alpha
CH54_2960	COG2264	protein methyltransferase activity
CH54_2961	COG4145	pantothenate transmembrane transporter activity
CH54_2962	COG3924	membrane
CH54_2963	COG0439	Biotin carboxylase
CH54_2964	COG0511	ligase activity, forming carbon-carbon bonds
CH54_2965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CH54_2966	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CH54_2968	COG0604	alcohol dehydrogenase
CH54_2969	COG2200	EAL domain
CH54_2969	COG2199	diguanylate cyclase activity
CH54_297	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH54_2970	COG1077	Cell shape determining protein MreB Mrl
CH54_2971	COG1792	Involved in formation and maintenance of cell shape
CH54_2972	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH54_2974	COG1530	ribonuclease E activity
CH54_2975	COG3164	Protein of unknown function
CH54_2976	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH54_2977	COG0312	modulator of DNA gyrase
CH54_2978	COG0583	DNA-binding transcription factor activity
CH54_298	COG2814	Major facilitator Superfamily
CH54_2980	COG1566	PFAM secretion protein HlyD family protein
CH54_2981	COG1289	transmembrane transporter activity
CH54_2984	COG2732	(Barnase) inhibitor
CH54_2985	COG3028	Belongs to the UPF0307 family
CH54_2986	COG0312	modulator of DNA gyrase
CH54_2987	COG3783	Cytochrome b(562)
CH54_2988	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH54_299	COG0583	DNA-binding transcription factor activity
CH54_2994	COG3964	amidohydrolase
CH54_2997	COG2706	6-phosphogluconolactonase activity
CH54_2998	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_2998	COG3711	transcriptional antiterminator
CH54_2999	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH54_3	COG2995	paraquat-inducible protein a
CH54_300	COG1609	Transcriptional regulator
CH54_3001	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_3001	COG1263	PTS System
CH54_3002	COG0366	Alpha amylase catalytic
CH54_3004	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CH54_3005	COG0540	Belongs to the ATCase OTCase family
CH54_3007	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_3008	COG1660	Displays ATPase and GTPase activities
CH54_3009	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_3011	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH54_3012	COG1137	ATPase activity
CH54_3013	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH54_3014	COG3117	lipopolysaccharide transmembrane transporter activity
CH54_3015	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH54_3016	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH54_3016	COG0517	IMP dehydrogenase activity
CH54_3017	COG0530	calcium, potassium:sodium antiporter activity
CH54_3018	COG1127	ABC transporter
CH54_3019	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH54_302	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH54_3020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH54_3021	COG2854	intermembrane phospholipid transfer
CH54_3022	COG3113	response to antibiotic
CH54_3023	COG5007	Belongs to the BolA IbaG family
CH54_3024	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CH54_3025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH54_3026	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH54_3027	COG3105	Protein conserved in bacteria
CH54_3028	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH54_3029	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CH54_303	COG0791	NLP P60 protein
CH54_3030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CH54_3031	COG0625	glutathione transferase activity
CH54_3032	COG2969	positive regulation of protein catabolic process
CH54_3034	COG0493	'glutamate synthase
CH54_3035	COG0069	glutamate synthase activity
CH54_3035	COG0070	glutamate synthase
CH54_3035	COG0067	glutamate synthase
CH54_3036	COG1242	4 iron, 4 sulfur cluster binding
CH54_3037	COG2198	Histidine kinase
CH54_3037	COG5002	protein histidine kinase activity
CH54_3037	COG0784	Response regulator, receiver
CH54_3038	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH54_3039	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH54_304	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH54_3040	COG2823	Periplasmic or secreted lipoprotein
CH54_3041	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH54_3042	COG0792	nuclease activity
CH54_3044	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH54_305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH54_306	COG0346	lactoylglutathione lyase activity
CH54_3061	COG0667	Aldo Keto reductase
CH54_3063	COG4221	oxidoreductase activity
CH54_3064	COG1064	alcohol dehydrogenase
CH54_3065	COG1741	Belongs to the pirin family
CH54_3066	COG0583	DNA-binding transcription factor activity
CH54_3067	COG0435	Glutathione S-transferase
CH54_3068	COG2259	Doxx family
CH54_307	COG1902	pentaerythritol trinitrate reductase activity
CH54_3070	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH54_3071	COG4575	ribosome binding
CH54_3074	COG0586	Pfam SNARE associated Golgi protein
CH54_3077	COG2271	Major facilitator Superfamily
CH54_3078	COG1904	glucuronate isomerase
CH54_3079	COG0246	Mannitol dehydrogenase
CH54_308	COG1309	transcriptional regulator
CH54_3080	COG2721	sulfolactate sulfo-lyase activity
CH54_3082	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CH54_3083	COG0861	Integral membrane protein TerC family
CH54_3084	COG0673	inositol 2-dehydrogenase activity
CH54_3085	COG1451	nucleotide metabolic process
CH54_3087	COG2813	Specifically methylates the guanine in position
CH54_3088	COG1902	pentaerythritol trinitrate reductase activity
CH54_3088	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH54_309	COG2194	sulfuric ester hydrolase activity
CH54_3090	COG3247	response to pH
CH54_3092	COG0076	glutamate decarboxylase activity
CH54_3093	COG0531	amino acid
CH54_3095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_3095	COG1263	PTS System
CH54_3096	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CH54_3098	COG1472	Belongs to the glycosyl hydrolase 3 family
CH54_3100	COG3876	Protein conserved in bacteria
CH54_3102	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH54_3103	COG0358	DNA primase activity
CH54_3106	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CH54_3107	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CH54_3108	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH54_3109	COG1968	undecaprenyl-diphosphatase activity
CH54_311	COG3313	Fe-S protein
CH54_3110	COG0617	tRNA 3'-terminal CCA addition
CH54_3111	COG4991	sh3 domain protein
CH54_3112	COG3025	triphosphatase activity
CH54_3113	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CH54_3114	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH54_3114	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CH54_3115	COG0531	amino acid
CH54_3117	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH54_3118	COG3384	dioxygenase
CH54_3119	COG0754	glutathionylspermidine amidase activity
CH54_3120	COG5463	Belongs to the UPF0441 family
CH54_3121	COG1538	Outer membrane efflux protein
CH54_3122	COG0494	nUDIX hydrolase
CH54_3123	COG3151	Protein conserved in bacteria
CH54_3124	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH54_3125	COG3150	esterase
CH54_3126	COG0187	DNA topoisomerase II activity
CH54_3127	COG0583	DNA-binding transcription factor activity
CH54_3128	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH54_3129	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH54_313	COG4989	oxidoreductase activity
CH54_3131	COG0204	Acyl-transferase
CH54_3132	COG2132	Multicopper oxidase
CH54_3134	COG0656	L-ascorbic acid biosynthetic process
CH54_3135	COG1979	alcohol dehydrogenase
CH54_3136	COG2207	Transcriptional regulator
CH54_3137	COG0586	Pfam SNARE associated Golgi protein
CH54_3139	COG0811	peptide transport
CH54_314	COG1289	transmembrane transporter activity
CH54_3140	COG0848	biopolymer transport protein
CH54_315	COG1566	PFAM secretion protein HlyD family protein
CH54_3150	COG4964	Belongs to the GSP D family
CH54_3156	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH54_3157	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_3161	COG4774	siderophore transport
CH54_3164	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH54_3167	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH54_3168	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH54_3169	COG1120	ATPase activity
CH54_317	COG1846	Transcriptional regulator
CH54_3170	COG4592	Periplasmic binding protein
CH54_3171	COG1169	isochorismate synthase
CH54_3172	COG1021	2,3-dihydroxybenzoate-AMP ligase
CH54_3173	COG1535	isochorismatase
CH54_3173	COG3433	isochorismatase activity
CH54_3174	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_3175	COG2271	Major facilitator Superfamily
CH54_3176	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH54_3179	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH54_318	COG3133	Outer membrane lipoprotein
CH54_3181	COG1987	bacterial-type flagellum assembly
CH54_3185	COG2204	response regulator
CH54_3186	COG1677	Flagellar hook-basal body complex protein FliE
CH54_319	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH54_3195	COG1815	bacterial-type flagellum-dependent cell motility
CH54_3196	COG1558	bacterial-type flagellum-dependent cell motility
CH54_3197	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH54_320	COG3895	Periplasmic Protein
CH54_3200	COG4786	Flagellar basal body rod
CH54_3202	COG1706	bacterial-type flagellum-dependent cell motility
CH54_3205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH54_3208	COG3710	Transcriptional regulator
CH54_3209	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH54_3210	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CH54_3211	COG1516	flagellar protein fliS
CH54_3215	COG1191	sigma factor activity
CH54_3216	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CH54_3218	COG3133	Outer membrane lipoprotein
CH54_3219	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CH54_322	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CH54_3220	COG0437	4 iron, 4 sulfur cluster binding
CH54_3221	COG5557	Pfam Polysulphide reductase, NrfD
CH54_3222	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CH54_3223	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH54_3224	COG1773	rubredoxin
CH54_3225	COG0375	protein maturation
CH54_3226	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH54_3227	COG0298	carbon dioxide binding
CH54_3228	COG0409	Hydrogenase expression formation protein
CH54_3229	COG0309	Hydrogenase expression formation protein (HypE)
CH54_3230	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CH54_3232	COG5001	Diguanylate cyclase
CH54_3233	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_3237	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CH54_3238	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH54_3239	COG1283	sodium-dependent phosphate transmembrane transporter activity
CH54_324	COG0625	glutathione transferase activity
CH54_3243	COG0477	Major facilitator Superfamily
CH54_3246	COG4607	ABC-type enterochelin transport system periplasmic component
CH54_3248	COG4605	iron ion homeostasis
CH54_3249	COG4604	ABC transporter, ATP-binding protein
CH54_3250	COG0024	Methionine aminopeptidase
CH54_3255	COG1289	transmembrane transporter activity
CH54_3262	COG2885	chlorophyll binding
CH54_3266	COG3179	chitinase
CH54_3273	COG3179	chitinase
CH54_328	COG3104	oligopeptide transport
CH54_3293	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH54_3295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH54_3297	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH54_3298	COG0656	L-ascorbic acid biosynthetic process
CH54_330	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH54_330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH54_3305	COG2211	Major facilitator Superfamily
CH54_331	COG4172	Belongs to the ABC transporter superfamily
CH54_3315	COG2040	homocysteine
CH54_3320	COG3047	cAMP biosynthetic process
CH54_3320	COG2885	chlorophyll binding
CH54_333	COG4171	peptide transport system, permease
CH54_334	COG4168	peptide transport system, permease
CH54_3344	COG0210	DNA helicase
CH54_3349	COG0582	viral genome integration into host DNA
CH54_335	COG4166	transmembrane transport
CH54_3351	COG0305	Participates in initiation and elongation during chromosome replication
CH54_3355	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH54_3357	COG1982	Orn Lys Arg decarboxylase major
CH54_3359	COG0741	lytic transglycosylase activity
CH54_3360	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CH54_3361	COG1194	a g-specific adenine glycosylase
CH54_3362	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CH54_3363	COG3171	Protein conserved in bacteria
CH54_3364	COG2066	Belongs to the glutaminase family
CH54_3366	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH54_3367	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH54_3368	COG1872	DUF167
CH54_3369	COG0762	integral membrane protein
CH54_3370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH54_3371	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH54_3372	COG2805	Type II/IV secretion system protein
CH54_3374	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH54_3375	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CH54_3376	COG1678	Uncharacterized ACR, COG1678
CH54_3377	COG0189	ligase activity
CH54_3378	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH54_3379	COG2356	endonuclease I
CH54_338	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH54_3380	COG3091	SprT-like family
CH54_3381	COG0640	Transcriptional regulator
CH54_3385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CH54_3386	COG1166	arginine decarboxylase activity
CH54_3388	COG0501	Belongs to the peptidase M48B family
CH54_3389	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH54_339	COG1842	Phage shock protein A
CH54_3390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH54_3391	COG0126	phosphoglycerate kinase activity
CH54_3392	COG0191	fructose-bisphosphate aldolase activity
CH54_3395	COG1279	arginine transmembrane transporter activity
CH54_3397	COG0583	DNA-binding transcription factor activity
CH54_3398	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH54_3399	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH54_3400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH54_3401	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CH54_3402	COG3079	Belongs to the UPF0149 family
CH54_3403	COG0006	proline dipeptidase activity
CH54_3404	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH54_3405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH54_3406	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CH54_3407	COG0509	glycine decarboxylation via glycine cleavage system
CH54_3408	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH54_3408	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH54_3409	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_341	COG1983	PspC domain protein
CH54_3411	COG1272	protein, Hemolysin III
CH54_3412	COG0354	folic acid binding
CH54_3413	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CH54_3415	COG0745	RESPONSE REGULATOR receiver
CH54_3416	COG2205	protein histidine kinase activity
CH54_3417	COG4452	Inner membrane protein CreD
CH54_3418	COG0716	FMN binding
CH54_3419	COG4974	Belongs to the 'phage' integrase family
CH54_3420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH54_3421	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH54_3422	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CH54_3423	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CH54_3425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CH54_343	COG3106	COG3106 Predicted ATPase
CH54_344	COG3768	UPF0283 membrane protein
CH54_3444	COG1522	sequence-specific DNA binding
CH54_3447	COG2271	Major facilitator Superfamily
CH54_3448	COG1609	Transcriptional regulator
CH54_3449	COG0484	heat shock protein binding
CH54_3451	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_3452	COG1733	regulation of RNA biosynthetic process
CH54_3453	COG0288	reversible hydration of carbon dioxide
CH54_3457	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH54_3459	COG2165	general secretion pathway protein
CH54_3473	COG0583	DNA-binding transcription factor activity
CH54_3474	COG2814	Major facilitator Superfamily
CH54_3475	COG0583	DNA-binding transcription factor activity
CH54_3476	COG0019	diaminopimelate decarboxylase activity
CH54_3477	COG1609	Transcriptional regulator
CH54_3479	COG0318	PFAM AMP-dependent synthetase and ligase
CH54_3479	COG0204	Acyl-transferase
CH54_348	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH54_3480	COG0477	Major facilitator Superfamily
CH54_3481	COG0667	Aldo Keto reductase
CH54_3482	COG0861	Integral membrane protein TerC family
CH54_3483	COG3066	DNA modification
CH54_3484	COG1051	belongs to the nudix hydrolase family
CH54_3486	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CH54_3487	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CH54_349	COG2866	Carboxypeptidase
CH54_3491	COG4967	type IV pilus modification protein PilV
CH54_3492	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH54_3493	COG1025	Belongs to the peptidase M16 family
CH54_3494	COG1074	ATP-dependent DNA helicase activity
CH54_3495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH54_3496	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CH54_3496	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH54_3497	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH54_350	COG4948	Mandelate Racemase Muconate Lactonizing
CH54_3501	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH54_3502	COG2166	iron-sulfur cluster assembly
CH54_3503	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH54_3504	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH54_3506	COG0583	DNA-binding transcription factor activity
CH54_3507	COG2363	Small membrane protein
CH54_3508	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CH54_3509	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH54_351	COG4166	transmembrane transport
CH54_3510	COG1611	Belongs to the LOG family
CH54_3511	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH54_3511	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH54_3513	COG3098	single-species biofilm formation
CH54_3514	COG0564	pseudouridine synthase activity
CH54_3517	COG2171	N-acyltransferase activity
CH54_3518	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CH54_3519	COG0024	Methionine aminopeptidase
CH54_3520	COG0052	Belongs to the universal ribosomal protein uS2 family
CH54_3521	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CH54_3522	COG0528	UMP kinase activity
CH54_3523	COG0233	cytoplasmic translational termination
CH54_3524	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CH54_3525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CH54_3526	COG0575	Belongs to the CDS family
CH54_3527	COG0750	zinc metalloprotease
CH54_3529	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH54_353	COG0598	Magnesium transport protein CorA
CH54_3530	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH54_3531	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH54_3532	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH54_3533	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH54_3534	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CH54_3535	COG0587	DNA-directed DNA polymerase activity
CH54_3536	COG0825	malonyl-CoA metabolic process
CH54_354	COG0037	tRNA processing
CH54_3540	COG0346	lactoylglutathione lyase activity
CH54_3541	COG0037	tRNA processing
CH54_3543	COG4568	rho-dependent transcription termination
CH54_3545	COG4681	YaeQ
CH54_3547	COG3015	lipoprotein NlpE involved in copper resistance
CH54_3548	COG0442	prolyl-tRNA aminoacylation
CH54_3549	COG1720	tRNA m6t6A37 methyltransferase activity
CH54_3551	COG1464	Belongs to the NlpA lipoprotein family
CH54_3552	COG2011	ABC-type metal ion transport system permease component
CH54_3554	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH54_356	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH54_356	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH54_356	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH54_356	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH54_3560	COG5544	Lipoprotein
CH54_3561	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH54_3562	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH54_3562	COG1042	CoA-binding domain protein
CH54_3562	COG0045	succinate-CoA ligase (ADP-forming) activity
CH54_3564	COG3118	belongs to the thioredoxin family
CH54_3565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH54_3566	COG2814	Major facilitator Superfamily
CH54_3567	COG1566	PFAM secretion protein HlyD family protein
CH54_3568	COG1846	Transcriptional regulator
CH54_3570	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH54_3571	COG2814	Major facilitator Superfamily
CH54_3573	COG0436	Aminotransferase
CH54_3574	COG0235	Class ii aldolase
CH54_3575	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CH54_3576	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CH54_3577	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CH54_3578	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CH54_3579	COG1960	acyl-CoA dehydrogenase activity
CH54_358	COG1285	pathogenesis
CH54_3580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH54_3581	COG3034	peptidoglycan biosynthetic process
CH54_3582	COG0121	glutamine amidotransferase
CH54_3583	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH54_3584	COG1805	sodium ion transport
CH54_3585	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH54_3586	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH54_3587	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH54_3588	COG2871	sodium ion transport
CH54_3589	COG1477	protein flavinylation
CH54_359	COG3042	response to heat
CH54_3590	COG2991	Protein conserved in bacteria
CH54_3593	COG1181	Belongs to the D-alanine--D-alanine ligase family
CH54_3594	COG2964	Protein conserved in bacteria
CH54_3597	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CH54_3598	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH54_3599	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH54_360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH54_3603	COG1086	Polysaccharide biosynthesis protein
CH54_3608	COG0438	transferase activity, transferring glycosyl groups
CH54_361	COG2911	Protein conserved in bacteria
CH54_3611	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH54_3613	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CH54_3616	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CH54_3618	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CH54_3619	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH54_3620	COG2313	pseudouridylate synthase activity
CH54_3621	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH54_3622	COG2188	Transcriptional regulator
CH54_3626	COG3459	Glycosyltransferase 36 associated
CH54_3629	COG2226	methyltransferase
CH54_363	COG3784	Protein of unknown function (DUF1318)
CH54_3636	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH54_3637	COG3123	guanosine phosphorylase activity
CH54_3638	COG2974	May be involved in recombination
CH54_3639	COG1940	carbohydrate kinase activity
CH54_364	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CH54_3640	COG0419	ATPase involved in DNA repair
CH54_3641	COG0420	3'-5' exonuclease activity
CH54_3643	COG0745	RESPONSE REGULATOR receiver
CH54_3644	COG5002	protein histidine kinase activity
CH54_3646	COG1114	Component of the transport system for branched-chain amino acids
CH54_3648	COG0366	Alpha amylase catalytic
CH54_365	COG1643	Atp-dependent helicase
CH54_3651	COG0450	alkyl hydroperoxide reductase
CH54_3652	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH54_3653	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CH54_3657	COG0343	queuine tRNA-ribosyltransferase activity
CH54_3658	COG1862	Preprotein translocase
CH54_3659	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH54_3660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH54_3663	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH54_3663	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH54_3664	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CH54_3665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH54_3666	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH54_3667	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH54_3668	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CH54_3669	COG0142	geranyltranstransferase activity
CH54_3670	COG1722	exodeoxyribonuclease VII activity
CH54_3671	COG0301	tRNA thio-modification
CH54_3671	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH54_3672	COG0693	protein deglycase activity
CH54_3673	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH54_3674	COG1666	GTP binding
CH54_3675	COG2814	Major facilitator Superfamily
CH54_3676	COG0109	protoheme IX farnesyltransferase activity
CH54_3677	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH54_3678	COG1845	cytochrome c oxidase, subunit III
CH54_3679	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH54_368	COG3591	Belongs to the peptidase S1B family
CH54_3680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH54_3682	COG2223	nitrite transmembrane transporter activity
CH54_3683	COG3056	Lipoprotein
CH54_3684	COG0271	Belongs to the BolA IbaG family
CH54_3685	COG0544	peptidyl-prolyl cis-trans isomerase activity
CH54_3687	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH54_3688	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH54_3689	COG0776	regulation of translation
CH54_3691	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH54_3692	COG1555	photosystem II stabilization
CH54_3693	COG0824	Thioesterase
CH54_3694	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CH54_3695	COG4533	DNA binding
CH54_3696	COG0561	phosphatase activity
CH54_3698	COG1522	sequence-specific DNA binding
CH54_3699	COG1132	(ABC) transporter
CH54_3700	COG1132	(ABC) transporter
CH54_3701	COG0347	Belongs to the P(II) protein family
CH54_3702	COG0004	ammonium transporteR
CH54_3703	COG1946	Acyl-CoA thioesterase
CH54_3704	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH54_3705	COG3695	enzyme binding
CH54_3709	COG1121	(ABC) transporter
CH54_371	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH54_3710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH54_3711	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH54_3712	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH54_3713	COG0254	rRNA binding
CH54_3716	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH54_3717	COG3457	Alanine racemase
CH54_3719	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH54_372	COG2205	protein histidine kinase activity
CH54_3720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_3721	COG1309	transcriptional regulator
CH54_3722	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH54_3723	COG3264	Mechanosensitive ion channel
CH54_3723	COG1196	nuclear chromosome segregation
CH54_3725	COG2832	Protein of unknown function (DUF454)
CH54_3726	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH54_3727	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CH54_3728	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CH54_3729	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CH54_373	COG0745	RESPONSE REGULATOR receiver
CH54_3730	COG0326	Molecular chaperone. Has ATPase activity
CH54_3731	COG0563	adenylate kinase activity
CH54_3732	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CH54_3733	COG2244	polysaccharide biosynthetic process
CH54_3734	COG1442	glycosyl transferase family 8
CH54_3734	COG1216	Glycosyl transferase, family 2
CH54_3735	COG1215	transferase activity, transferring glycosyl groups
CH54_3736	COG0438	transferase activity, transferring glycosyl groups
CH54_3737	COG0438	transferase activity, transferring glycosyl groups
CH54_3738	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH54_3742	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH54_3743	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH54_3743	COG4651	solute:proton antiporter activity
CH54_3744	COG2223	nitrite transmembrane transporter activity
CH54_3745	COG0737	Belongs to the 5'-nucleotidase family
CH54_3746	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH54_3747	COG3735	TraB family
CH54_3748	COG2217	Heavy metal translocating P-type atpase
CH54_3749	COG0789	Transcriptional regulator
CH54_375	COG0531	amino acid
CH54_3750	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH54_3751	COG0330	HflC and HflK could
CH54_3752	COG3118	belongs to the thioredoxin family
CH54_3753	COG0300	oxidoreductase activity
CH54_3754	COG2755	lipolytic protein G-D-S-L family
CH54_3755	COG4181	ATPase activity
CH54_3756	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH54_3757	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH54_3758	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH54_3759	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH54_3760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH54_3761	COG0215	cysteine-tRNA ligase activity
CH54_3762	COG2501	S4 domain
CH54_3763	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CH54_3765	COG0582	viral genome integration into host DNA
CH54_377	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH54_3776	COG3723	Recombinational DNA repair protein, rece pathway
CH54_378	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH54_379	COG0589	response to stress
CH54_3793	COG0305	Participates in initiation and elongation during chromosome replication
CH54_38	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CH54_380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH54_3806	COG3772	lysozyme
CH54_381	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH54_3811	COG3728	DNA packaging
CH54_384	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CH54_3843	COG0582	viral genome integration into host DNA
CH54_3845	COG2116	formate transmembrane transporter activity
CH54_3847	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH54_3848	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH54_3849	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH54_3850	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CH54_3851	COG1138	Cytochrome C-type biogenesis protein
CH54_3852	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH54_3853	COG4235	cytochrome complex assembly
CH54_3853	COG3088	subunit of a heme lyase
CH54_3854	COG3088	subunit of a heme lyase
CH54_3854	COG4235	cytochrome complex assembly
CH54_3857	COG3691	Protein conserved in bacteria
CH54_3858	COG0183	Belongs to the thiolase family
CH54_3859	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH54_3859	COG1024	Enoyl-CoA hydratase
CH54_3860	COG2062	phosphohistidine phosphatase, SixA
CH54_3861	COG2840	Smr protein MutS2
CH54_3862	COG2890	protein-(glutamine-N5) methyltransferase activity
CH54_3863	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CH54_3864	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH54_3865	COG0730	response to heat
CH54_3866	COG3101	peptidyl-lysine hydroxylation
CH54_3868	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CH54_3868	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH54_3869	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH54_387	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_3870	COG3706	GGDEF domain
CH54_3871	COG1794	racemase activity, acting on amino acids and derivatives
CH54_3873	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH54_3874	COG2723	6-phospho-beta-galactosidase activity
CH54_3875	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH54_3877	COG1609	Transcriptional regulator
CH54_3879	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH54_3881	COG4232	protein-disulfide reductase activity
CH54_3883	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH54_3884	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH54_3886	COG0697	spore germination
CH54_3887	COG2207	Transcriptional regulator
CH54_3888	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH54_3889	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH54_3892	COG0586	Pfam SNARE associated Golgi protein
CH54_3895	COG0285	dihydrofolate synthase activity
CH54_3897	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH54_3898	COG1286	toxin biosynthetic process
CH54_3899	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH54_39	COG0437	4 iron, 4 sulfur cluster binding
CH54_390	COG1011	Hydrolase
CH54_3900	COG0163	prenyltransferase activity
CH54_3901	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_3902	COG4215	(ABC) transporter
CH54_3903	COG4160	amino acid transport
CH54_3904	COG4598	ABC transporter
CH54_3905	COG1090	epimerase
CH54_3907	COG0622	Phosphoesterase
CH54_3908	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH54_3909	COG3037	sugar-specific permease SgaT UlaA
CH54_391	COG0440	acetolactate synthase activity
CH54_3912	COG1609	Transcriptional regulator
CH54_3913	COG0280	phosphate acetyltransferase
CH54_3913	COG0857	belongs to the CobB CobQ family
CH54_3915	COG3092	negative regulation of chromosome organization
CH54_3916	COG3013	Belongs to the UPF0304 family
CH54_3917	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH54_392	COG0028	Belongs to the TPP enzyme family
CH54_3920	COG0471	metal ion transport
CH54_3920	COG0490	domain, Protein
CH54_3921	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CH54_3923	COG0436	Aminotransferase
CH54_3924	COG0583	DNA-binding transcription factor activity
CH54_3926	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH54_3927	COG0649	NAD binding
CH54_3927	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH54_3928	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CH54_3930	COG1034	ATP synthesis coupled electron transport
CH54_3931	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CH54_3932	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH54_3933	COG0839	Belongs to the complex I subunit 6 family
CH54_3934	COG0713	ATP synthesis coupled electron transport
CH54_3935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH54_3936	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH54_3937	COG1007	ATP synthesis coupled electron transport
CH54_394	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH54_3940	COG2731	YhcH YjgK YiaL family protein
CH54_3941	COG3265	gluconokinase activity
CH54_3942	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_3943	COG1609	Transcriptional regulator
CH54_3944	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH54_3946	COG4702	Belongs to the UPF0303 family
CH54_3947	COG0129	dihydroxy-acid dehydratase activity
CH54_3948	COG4575	ribosome binding
CH54_3950	COG1169	isochorismate synthase
CH54_3951	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CH54_3952	COG0596	Alpha beta hydrolase
CH54_3953	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH54_3954	COG1441	menaquinone biosynthetic process
CH54_3958	COG0814	amino acid
CH54_3960	COG4574	serine-type endopeptidase inhibitor activity
CH54_3961	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH54_3963	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH54_3964	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH54_3966	COG2205	protein histidine kinase activity
CH54_3966	COG0784	Response regulator, receiver
CH54_3968	COG2198	Histidine kinase
CH54_3968	COG0642	Histidine kinase
CH54_3969	COG2223	nitrite transmembrane transporter activity
CH54_3972	COG1132	(ABC) transporter
CH54_3974	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH54_3977	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH54_398	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH54_3985	COG2190	(PTS) system
CH54_3985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_3985	COG1263	PTS System
CH54_3986	COG2723	6-phospho-beta-galactosidase activity
CH54_3989	COG3082	Protein of unknown function (DUF1414)
CH54_3990	COG3081	Nucleoid-associated protein
CH54_3992	COG1061	Type III restriction enzyme res subunit
CH54_3993	COG1187	pseudouridine synthase activity
CH54_3994	COG2814	Major facilitator Superfamily
CH54_3996	COG4172	Belongs to the ABC transporter superfamily
CH54_3997	COG4239	(ABC) transporter, permease
CH54_3998	COG4174	ABC transporter (Permease)
CH54_3999	COG4166	transmembrane transport
CH54_4	COG3008	intermembrane lipid transfer
CH54_4	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH54_40	COG3301	Polysulphide reductase, NrfD
CH54_4000	COG2200	EAL domain
CH54_4001	COG0791	NLP P60 protein
CH54_4002	COG0523	cobalamin synthesis protein
CH54_4004	COG2186	Transcriptional regulator
CH54_4005	COG0246	Mannitol dehydrogenase
CH54_4006	COG1312	Catalyzes the dehydration of D-mannonate
CH54_4007	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH54_4013	COG1105	Belongs to the carbohydrate kinase PfkB family
CH54_4014	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH54_4014	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH54_4014	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH54_4015	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CH54_4016	COG2855	membrane
CH54_402	COG4215	(ABC) transporter
CH54_4020	COG0583	DNA-binding transcription factor activity
CH54_4021	COG0833	amino acid
CH54_4022	COG4139	cobalamin transport
CH54_4023	COG4771	TonB-dependent receptor
CH54_4024	COG0625	glutathione transferase activity
CH54_4030	COG2011	ABC-type metal ion transport system permease component
CH54_4033	COG0626	cystathionine gamma-synthase activity
CH54_4035	COG1686	Belongs to the peptidase S11 family
CH54_4036	COG1760	l-serine dehydratase
CH54_4037	COG0814	amino acid
CH54_4038	COG1349	DNA-binding transcription factor activity
CH54_4039	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH54_404	COG1522	sequence-specific DNA binding
CH54_4040	COG0671	phosphoesterase, PA-phosphatase related
CH54_4042	COG2985	domain, Protein
CH54_4042	COG0569	domain protein
CH54_4043	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH54_4046	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH54_4047	COG3842	ATPase activity
CH54_4048	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH54_4049	COG1177	transmembrane transport
CH54_4051	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH54_4052	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_4053	COG4160	amino acid transport
CH54_4054	COG4215	(ABC) transporter
CH54_4055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_4056	COG1126	abc transporter atp-binding protein
CH54_4058	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH54_4059	COG0702	epimerase
CH54_406	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH54_4060	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH54_4062	COG0028	Belongs to the TPP enzyme family
CH54_4063	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH54_4064	COG1151	hydroxylamine reductase activity
CH54_4065	COG2431	L-lysine efflux transmembrane transporter activity
CH54_4066	COG3593	DNA synthesis involved in DNA repair
CH54_4067	COG2990	Protein conserved in bacteria
CH54_4068	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_407	COG1773	rubredoxin
CH54_407	COG0426	domain, Protein
CH54_4070	COG1278	Cold shock
CH54_4071	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CH54_4072	COG0542	response to heat
CH54_4073	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH54_4074	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CH54_4075	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH54_4078	COG0492	ferredoxin-NADP+ reductase activity
CH54_408	COG3604	Transcriptional regulator
CH54_4080	COG1522	sequence-specific DNA binding
CH54_4081	COG1674	ftsk spoiiie
CH54_4081	COG3107	peptidoglycan biosynthetic process
CH54_4082	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CH54_4083	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH54_4084	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CH54_4085	COG2814	Major facilitator Superfamily
CH54_4086	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH54_4087	COG1882	Formate acetyltransferase
CH54_4088	COG2116	formate transmembrane transporter activity
CH54_4089	COG1944	ATP diphosphatase activity
CH54_409	COG0625	glutathione transferase activity
CH54_4090	COG0252	asparaginase activity
CH54_4091	COG2323	membrane
CH54_4093	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CH54_4094	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CH54_4095	COG0539	negative regulation of cytoplasmic translation
CH54_4098	COG2333	competence protein COMEC
CH54_4098	COG0658	competence protein
CH54_41	COG1138	Cytochrome C-type biogenesis protein
CH54_4100	COG1663	tetraacyldisaccharide 4'-kinase activity
CH54_4101	COG5383	Protein conserved in bacteria
CH54_4102	COG1278	Cold shock
CH54_4103	COG2835	tetraacyldisaccharide 4'-kinase activity
CH54_4104	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CH54_4105	COG3173	Aminoglycoside phosphotransferase
CH54_4106	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CH54_4107	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH54_4108	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH54_4109	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CH54_4110	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CH54_4111	COG2989	Protein conserved in bacteria
CH54_4112	COG3108	Peptidase M15
CH54_4113	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH54_4114	COG2200	EAL domain
CH54_4115	COG1448	Aminotransferase
CH54_4117	COG0017	Asparaginyl-tRNA synthetase
CH54_4118	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CH54_4119	COG0308	aminopeptidase N
CH54_4120	COG0167	dihydroorotate dehydrogenase activity
CH54_4122	COG0633	Ferredoxin
CH54_4122	COG3217	Mosc domain protein beta barrel domain protein
CH54_413	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CH54_42	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH54_420	COG0640	Transcriptional regulator
CH54_421	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH54_422	COG1393	Belongs to the ArsC family
CH54_423	COG3316	Transposase and inactivated derivatives
CH54_424	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH54_425	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CH54_426	COG3316	Transposase and inactivated derivatives
CH54_428	COG4221	oxidoreductase activity
CH54_429	COG1742	UPF0060 membrane protein
CH54_43	COG3088	subunit of a heme lyase
CH54_43	COG4235	cytochrome complex assembly
CH54_433	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH54_434	COG1940	carbohydrate kinase activity
CH54_435	COG0583	DNA-binding transcription factor activity
CH54_436	COG2814	Major facilitator Superfamily
CH54_44	COG4235	cytochrome complex assembly
CH54_440	COG0114	fumarate hydratase activity
CH54_442	COG5339	Protein conserved in bacteria
CH54_445	COG1609	Transcriptional regulator
CH54_447	COG1263	PTS System
CH54_447	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_448	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH54_449	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CH54_450	COG0385	Bile acid
CH54_451	COG0673	inositol 2-dehydrogenase activity
CH54_457	COG2160	L-arabinose isomerase activity
CH54_458	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH54_462	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CH54_466	COG4656	Part of a membrane complex involved in electron transport
CH54_467	COG3708	Transcriptional regulator
CH54_467	COG2207	Transcriptional regulator
CH54_468	COG4658	electron transport chain
CH54_469	COG4659	FMN binding
CH54_47	COG3263	regulation of cellular component size
CH54_471	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH54_475	COG0243	molybdopterin cofactor binding
CH54_477	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CH54_478	COG1966	Carbon starvation protein
CH54_479	COG2879	small protein
CH54_480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH54_481	COG1349	DNA-binding transcription factor activity
CH54_483	COG0235	Class ii aldolase
CH54_485	COG0023	Translation Initiation Factor
CH54_486	COG0284	orotidine-5'-phosphate decarboxylase activity
CH54_489	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH54_490	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH54_491	COG0671	phosphoesterase, PA-phosphatase related
CH54_492	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH54_496	COG0583	DNA-binding transcription factor activity
CH54_497	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH54_499	COG0616	signal peptide processing
CH54_5	COG3009	Protein conserved in bacteria
CH54_50	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CH54_500	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_501	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CH54_503	COG1187	pseudouridine synthase activity
CH54_51	COG2943	transferase activity, transferring hexosyl groups
CH54_52	COG5645	(Lipo)protein
CH54_523	COG0009	L-threonylcarbamoyladenylate synthase
CH54_524	COG0613	PHP domain protein
CH54_525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CH54_526	COG0512	Glutamine amidotransferase of anthranilate synthase
CH54_528	COG0135	phosphoribosylanthranilate isomerase activity
CH54_528	COG0134	indole-3-glycerol-phosphate synthase activity
CH54_529	COG0133	tryptophan synthase activity
CH54_530	COG0159	tryptophan synthase activity
CH54_532	COG3047	cAMP biosynthetic process
CH54_535	COG2917	probably involved in intracellular septation
CH54_536	COG1607	acyl-coa hydrolase
CH54_537	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH54_538	COG2350	Protein conserved in bacteria
CH54_541	COG2200	EAL domain
CH54_542	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH54_544	COG4608	Belongs to the ABC transporter superfamily
CH54_545	COG0444	Belongs to the ABC transporter superfamily
CH54_546	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH54_55	COG3104	oligopeptide transport
CH54_550	COG2095	MarC family integral membrane protein
CH54_551	COG1012	belongs to the aldehyde dehydrogenase family
CH54_551	COG1454	alcohol dehydrogenase
CH54_554	COG1435	thymidine kinase activity
CH54_555	COG2916	Histone family protein nucleoid-structuring protein H-NS
CH54_557	COG0745	RESPONSE REGULATOR receiver
CH54_558	COG1752	Esterase of the alpha-beta hydrolase superfamily
CH54_56	COG2814	Major facilitator Superfamily
CH54_560	COG3012	SEC-C Motif Domain Protein
CH54_561	COG0788	formyltetrahydrofolate deformylase activity
CH54_565	COG0583	DNA-binding transcription factor activity
CH54_566	COG0708	Exodeoxyribonuclease III
CH54_567	COG0494	nUDIX hydrolase
CH54_569	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH54_57	COG2259	Doxx family
CH54_571	COG0778	Nitroreductase
CH54_572	COG0616	signal peptide processing
CH54_573	COG0252	asparaginase activity
CH54_574	COG1335	isochorismatase
CH54_575	COG3139	Protein of unknown function (DUF1315)
CH54_576	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH54_579	COG3713	MltA-interacting MipA family protein
CH54_580	COG2766	serine protein kinase
CH54_581	COG2718	Belongs to the UPF0229 family
CH54_583	COG0583	DNA-binding transcription factor activity
CH54_585	COG2200	EAL domain
CH54_585	COG2199	diguanylate cyclase activity
CH54_585	COG2202	Pas domain
CH54_586	COG2814	Major facilitator Superfamily
CH54_587	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH54_588	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH54_589	COG2719	SpoVR family
CH54_59	COG1560	Kdo2-lipid A biosynthetic process
CH54_590	COG2186	Transcriptional regulator
CH54_591	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH54_592	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CH54_595	COG2983	Belongs to the UPF0260 family
CH54_596	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH54_597	COG2951	lytic endotransglycosylase activity
CH54_598	COG3100	YcgL domain-containing protein
CH54_6	COG3130	regulation of translation
CH54_600	COG0850	regulation of cytokinetic process
CH54_601	COG2894	cell division
CH54_602	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH54_603	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH54_604	COG0318	PFAM AMP-dependent synthetase and ligase
CH54_605	COG3065	identical protein binding
CH54_607	COG1199	ATP-dependent helicase activity
CH54_608	COG0251	oxidation-reduction process
CH54_609	COG2076	Multidrug Resistance protein
CH54_610	COG2076	Multidrug Resistance protein
CH54_611	COG0800	Aldolase
CH54_612	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH54_613	COG1737	Transcriptional regulator
CH54_614	COG0469	pyruvate kinase activity
CH54_615	COG1560	Kdo2-lipid A biosynthetic process
CH54_616	COG0739	heme binding
CH54_617	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH54_618	COG1121	(ABC) transporter
CH54_619	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH54_62	COG0628	permease
CH54_620	COG3104	oligopeptide transport
CH54_621	COG2255	four-way junction helicase activity
CH54_622	COG0632	four-way junction helicase activity
CH54_623	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CH54_624	COG0217	transcriptional regulatory protein
CH54_625	COG0494	nUDIX hydrolase
CH54_627	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CH54_628	COG1335	isochorismatase
CH54_629	COG1801	Protein of unknown function DUF72
CH54_630	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH54_631	COG2226	methyltransferase
CH54_632	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH54_633	COG3142	Participates in the control of copper homeostasis
CH54_634	COG3102	Protein conserved in bacteria
CH54_635	COG0018	arginyl-trna synthetase
CH54_636	COG0728	peptidoglycan biosynthetic process
CH54_637	COG0673	inositol 2-dehydrogenase activity
CH54_639	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH54_640	COG0477	Major facilitator Superfamily
CH54_642	COG3381	protein complex oligomerization
CH54_643	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CH54_644	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH54_650	COG0659	secondary active sulfate transmembrane transporter activity
CH54_651	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CH54_652	COG2912	Transglutaminase-like superfamily
CH54_653	COG3094	Invasion gene expression up-regulator, SirB
CH54_654	COG2890	protein-(glutamine-N5) methyltransferase activity
CH54_655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CH54_656	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CH54_657	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CH54_659	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH54_661	COG0193	aminoacyl-tRNA hydrolase activity
CH54_663	COG0012	GTP binding
CH54_665	COG4942	peptidase
CH54_667	COG3443	Belongs to the bacterial solute-binding protein 9 family
CH54_668	COG4211	Belongs to the binding-protein-dependent transport system permease family
CH54_669	COG1129	ABC transporter
CH54_672	COG0402	S-adenosylhomocysteine deaminase activity
CH54_674	COG1228	amidohydrolase
CH54_677	COG2988	succinylglutamate desuccinylase activity
CH54_678	COG3724	N-succinylarginine dihydrolase activity
CH54_68	COG0418	dihydroorotase activity
CH54_680	COG3138	arginine N-succinyltransferase
CH54_681	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CH54_682	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH54_684	COG1271	oxidase subunit
CH54_685	COG1294	oxidase, subunit
CH54_686	COG3850	Histidine kinase
CH54_687	COG0583	DNA-binding transcription factor activity
CH54_689	COG0387	Pfam Sodium calcium exchanger
CH54_69	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH54_690	COG1702	phosphate starvation-inducible protein PhoH
CH54_693	COG3658	cytochrome
CH54_694	COG1215	transferase activity, transferring glycosyl groups
CH54_695	COG1649	PFAM Uncharacterised BCR, COG1649
CH54_695	COG0726	polysaccharide deacetylase
CH54_696	COG0457	Tetratricopeptide repeat
CH54_697	COG0006	proline dipeptidase activity
CH54_698	COG4114	ferric iron reductase
CH54_699	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH54_7	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH54_70	COG1530	ribonuclease E activity
CH54_70	COG1530	ribonuclease E activity
CH54_704	COG0577	efflux transmembrane transporter activity
CH54_704	COG1136	(ABC) transporter
CH54_706	COG0577	efflux transmembrane transporter activity
CH54_706	COG1136	(ABC) transporter
CH54_709	COG0672	)-iron permease
CH54_71	COG0564	pseudouridine synthase activity
CH54_713	COG2066	Belongs to the glutaminase family
CH54_714	COG3622	Belongs to the hyi family
CH54_715	COG0235	Class ii aldolase
CH54_716	COG3395	kinase activity
CH54_717	COG1349	DNA-binding transcription factor activity
CH54_718	COG3290	protein histidine kinase activity
CH54_719	COG4565	transcriptional regulatory protein
CH54_720	COG3493	citrate carrier protein
CH54_728	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH54_729	COG0322	excinuclease ABC activity
CH54_73	COG1399	metal-binding, possibly nucleic acid-binding protein
CH54_730	COG2197	response regulator
CH54_733	COG0366	Alpha amylase catalytic
CH54_74	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH54_740	COG0582	viral genome integration into host DNA
CH54_741	COG0582	viral genome integration into host DNA
CH54_743	COG1113	amino acid transport
CH54_744	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CH54_746	COG3423	Transcriptional regulator
CH54_748	COG0477	Major facilitator Superfamily
CH54_749	COG0655	NAD(P)H dehydrogenase (quinone) activity
CH54_75	COG0416	fatty acid biosynthetic process
CH54_754	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH54_754	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH54_754	COG0506	proline dehydrogenase activity
CH54_761	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH54_763	COG1191	sigma factor activity
CH54_769	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH54_77	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH54_770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CH54_772	COG1677	Flagellar hook-basal body complex protein FliE
CH54_774	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH54_775	COG1317	bacterial-type flagellum organization
CH54_777	COG2882	bacterial-type flagellum organization
CH54_779	COG1580	Controls the rotational direction of flagella during chemotaxis
CH54_78	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_783	COG1338	Plays a role in the flagellum-specific transport system
CH54_786	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH54_787	COG1256	bacterial-type flagellum assembly
CH54_791	COG4786	Flagellar basal body rod
CH54_793	COG1749	Flagellar hook protein flgE
CH54_794	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH54_795	COG1558	bacterial-type flagellum-dependent cell motility
CH54_796	COG1815	bacterial-type flagellum-dependent cell motility
CH54_798	COG2747	anti-sigma28 factor FlgM
CH54_799	COG3418	PFAM FlgN family protein
CH54_80	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH54_802	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH54_803	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH54_805	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH54_806	COG0745	RESPONSE REGULATOR receiver
CH54_808	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH54_809	COG0840	transmembrane signaling receptor activity
CH54_81	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH54_810	COG0840	transmembrane signaling receptor activity
CH54_811	COG0835	chemotaxis
CH54_812	COG2198	Histidine kinase
CH54_812	COG0643	Histidine kinase
CH54_813	COG1360	Flagellar Motor Protein
CH54_817	COG0589	response to stress
CH54_818	COG2130	NADP-dependent
CH54_82	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH54_820	COG1285	pathogenesis
CH54_821	COG0840	transmembrane signaling receptor activity
CH54_823	COG1278	Cold shock
CH54_824	COG1609	Transcriptional regulator
CH54_825	COG3250	beta-galactosidase activity
CH54_826	COG3321	synthase
CH54_826	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_826	COG0604	alcohol dehydrogenase
CH54_83	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CH54_832	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH54_835	COG0671	phosphoesterase, PA-phosphatase related
CH54_835	COG2453	phosphatase
CH54_836	COG2267	carboxylic ester hydrolase activity
CH54_838	COG4589	Belongs to the CDS family
CH54_839	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH54_84	COG0470	DNA polymerase III
CH54_840	COG3121	Chaperone
CH54_844	COG3547	Transposase (IS116 IS110 IS902 family)
CH54_846	COG3228	Belongs to the MtfA family
CH54_85	COG0084	hydrolase, TatD family'
CH54_854	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH54_857	COG0471	metal ion transport
CH54_859	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CH54_859	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
CH54_86	COG1263	PTS System
CH54_86	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_860	COG3051	citrate lyase alpha subunit
CH54_861	COG2301	Belongs to the HpcH HpaI aldolase family
CH54_862	COG3052	prosthetic group binding
CH54_863	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CH54_864	COG3290	protein histidine kinase activity
CH54_865	COG4565	transcriptional regulatory protein
CH54_868	COG2271	Major facilitator Superfamily
CH54_869	COG1840	ABC-type Fe3 transport system, periplasmic component
CH54_871	COG3842	ATPase activity
CH54_877	COG4171	peptide transport system, permease
CH54_878	COG0601	transmembrane transport
CH54_880	COG4771	TonB-dependent receptor
CH54_882	COG1169	isochorismate synthase
CH54_883	COG1021	2,3-dihydroxybenzoate-AMP ligase
CH54_888	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH54_888	COG2226	methyltransferase
CH54_888	COG3433	isochorismatase activity
CH54_891	COG2977	Belongs to the P-Pant transferase superfamily
CH54_893	COG0251	oxidation-reduction process
CH54_896	COG2205	protein histidine kinase activity
CH54_896	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_898	COG3121	Chaperone
CH54_9	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH54_90	COG0641	radical SAM
CH54_901	COG3121	Chaperone
CH54_903	COG0784	Response regulator, receiver
CH54_903	COG0835	chemotaxis
CH54_904	COG0583	DNA-binding transcription factor activity
CH54_906	COG2814	Major facilitator Superfamily
CH54_907	COG1349	DNA-binding transcription factor activity
CH54_908	COG0561	phosphatase activity
CH54_909	COG0352	thiamine-phosphate diphosphorylase activity
CH54_911	COG0534	Mate efflux family protein
CH54_912	COG0137	argininosuccinate synthase activity
CH54_913	COG2211	Major facilitator Superfamily
CH54_914	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CH54_916	COG0583	DNA-binding transcription factor activity
CH54_917	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CH54_918	COG0406	alpha-ribazole phosphatase activity
CH54_921	COG1492	cobalamin metabolic process
CH54_93	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH54_931	COG2875	Belongs to the precorrin methyltransferase family
CH54_933	COG2241	protein methyltransferase activity
CH54_934	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CH54_936	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CH54_94	COG0537	adenosine 5'-monophosphoramidase activity
CH54_941	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CH54_948	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CH54_95	COG5633	Lipoprotein
CH54_954	COG1012	belongs to the aldehyde dehydrogenase family
CH54_956	COG4656	Part of a membrane complex involved in electron transport
CH54_958	COG4810	utilization protein
CH54_96	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CH54_960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH54_961	COG1648	precorrin-2 dehydrogenase activity
CH54_961	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH54_962	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH54_964	COG1879	ABC-type sugar transport system periplasmic component
CH54_966	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH54_969	COG1289	transmembrane transporter activity
CH54_97	COG0510	thiamine kinase activity
CH54_970	COG1022	Amp-dependent synthetase and ligase
CH54_970	COG3320	Male sterility
CH54_971	COG2925	Exonuclease
CH54_972	COG0531	amino acid
CH54_974	COG0371	Dehydrogenase
CH54_975	COG1129	ABC transporter
CH54_976	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH54_977	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH54_978	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CH54_98	COG1472	Belongs to the glycosyl hydrolase 3 family
CH54_980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH54_981	COG0131	Imidazoleglycerol-phosphate dehydratase
CH54_981	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH54_982	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CH54_983	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CH54_984	COG0107	imidazoleglycerol-phosphate synthase activity
CH54_985	COG0140	phosphoribosyl-ATP diphosphatase activity
CH54_985	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH54_986	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CH54_987	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH54_988	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH54_989	COG1253	flavin adenine dinucleotide binding
CH54_99	COG3150	esterase
CH54_990	COG3069	C4-dicarboxylate transmembrane transporter activity
CH54_991	COG2982	Protein involved in outer membrane biogenesis
CH54_992	COG0717	Belongs to the dCTP deaminase family
CH54_993	COG0572	uridine kinase
CH54_994	COG0489	protein tyrosine kinase activity
CH54_995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH54_995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH54_999	COG2814	Major facilitator Superfamily