locus-tag class description HRD68_00040 ENOG4108BUD transposase HRD68_00050 ENOG4108S1B Periplasmic chaperone protein HRD68_00055 ENOG4108D1K outer membrane usher protein HRD68_00100 ENOG4108BUD transposase HRD68_00130 ENOG4108X73 DNA- binding protein HRD68_00135 ENOG4105KF5 hemolysin expression-modulating protein HRD68_00170 ENOG4108PCE TRANSFER protein HRD68_00175 ENOG4105PDG Type IV secretion system protein VirB8 HRD68_00195 ENOG4105KRQ Addiction module toxin, Txe YoeB family HRD68_00200 ENOG4105VTW prevent-host-death family HRD68_00265 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HRD68_00275 ENOG4108BUD transposase HRD68_00290 ENOG4108BUD transposase HRD68_00310 ENOG4108BUD transposase HRD68_00340 ENOG4108BUD transposase HRD68_00365 ENOG4108BUD transposase HRD68_00370 ENOG4105VT3 DNA binding domain protein, excisionase family HRD68_00395 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HRD68_00400 ENOG4105KT5 UmuD protein HRD68_00480 ENOG41060NJ transcriptional regulator HRD68_00490 ENOG4105C87 Aminotransferase class I and II HRD68_00660 ENOG4108C33 Resolvase HRD68_00715 ENOG4106H6R UPF0380 protein HRD68_00805 ENOG4105VDM plasmid maintenance system antidote protein, xre family HRD68_00810 ENOG41080ET plasmid maintenance system killer protein HRD68_00825 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HRD68_00955 ENOG4107QHF type ii secretion system protein e HRD68_00970 ENOG4105K5T PilT protein HRD68_01120 ENOG4105TKZ Tail Sheath HRD68_01225 ENOG4105HRS Antitermination protein HRD68_01295 ENOG4105DFP Integrase HRD68_01305 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HRD68_01310 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HRD68_01320 ENOG4105KT5 UmuD protein HRD68_01325 ENOG4105DR4 Methyltransferase HRD68_01330 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HRD68_01335 ENOG4105K4P CoA-binding domain protein HRD68_01345 ENOG4108Z5K methylglyoxal synthase HRD68_01350 ENOG41088T4 Helicase IV HRD68_01355 ENOG410901E Membrane HRD68_01360 ENOG4105EM2 membrane HRD68_01365 ENOG4108RZ1 DNA transformation protein HRD68_01370 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HRD68_01380 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HRD68_01385 ENOG4105DAN ATP-dependent protease HRD68_01390 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HRD68_01400 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRD68_01405 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HRD68_01410 ENOG4108Q2G (LipO)protein HRD68_01415 ENOG4105DY2 Paraquat-inducible protein b HRD68_01420 ENOG4105F1S paraquat-inducible protein a HRD68_01425 ENOG4105C5H ABC transporter HRD68_01430 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HRD68_01435 ENOG4105QVC MOSC domain-containing protein HRD68_01440 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HRD68_01445 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HRD68_01450 ENOG4105CD8 aminopeptidase N HRD68_01455 ENOG4107RH7 Nicotinate phosphoribosyltransferase HRD68_01460 ENOG4105C5S asparaginyl-tRNA synthetase HRD68_01470 ENOG4105CGF Aromatic amino acid aminotransferase HRD68_01475 ENOG4105BZU Histidine kinase HRD68_01480 ENOG4105C5X domain protein HRD68_01485 ENOG4105EAQ (twin-arginine translocation) pathway signal HRD68_01490 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HRD68_01505 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HRD68_01510 ENOG4106371 Methyltransferase HRD68_01515 ENOG4107S90 membrAne HRD68_01520 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HRD68_01530 ENOG4105W49 UPF0434 protein HRD68_01535 ENOG4105VEQ Cold shock protein HRD68_01540 ENOG4105E32 cytoplasmic protein HRD68_01560 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HRD68_01565 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HRD68_01575 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HRD68_01585 ENOG4107VMU Membrane HRD68_01590 ENOG4105HDK L-asparaginase HRD68_01595 ENOG4105DDY UPF0142 protein ycaO HRD68_01600 ENOG4105TMB Formate nitrite transporter HRD68_01605 ENOG4105C6N Formate acetyltransferase HRD68_01610 ENOG4105F1A Pyruvate formate-lyase HRD68_01615 ENOG4108ISG Major Facilitator HRD68_01620 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HRD68_01625 ENOG4105D1H recombination factor protein RarA HRD68_01630 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HRD68_01635 ENOG4105CNU cell division protein FtsK HRD68_01640 ENOG4105EW9 transcriptional regulator AsnC family HRD68_01645 ENOG4105C3M thioredoxin reductase HRD68_01650 ENOG4108JJ9 ABC, transporter HRD68_01655 ENOG4108JJ8 (ABC) transporter HRD68_01660 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HRD68_01670 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HRD68_01675 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HRD68_01680 ENOG4105VEQ Cold shock protein HRD68_01690 ENOG4105DJY efflux transporter, rnd family, mfp subunit HRD68_01695 ENOG4108MJ5 VirK protein HRD68_01700 ENOG4105CPB ATP-dependent endonuclease of the OLD family HRD68_01705 ENOG4105DWU Membrane HRD68_01710 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HRD68_01715 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HRD68_01720 ENOG4105C7K acetolactate synthase HRD68_01730 ENOG4105C5W Aldolase HRD68_01735 ENOG4105CGD Nad-dependent epimerase dehydratase HRD68_01740 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HRD68_01745 ENOG41064MM (LipO)protein HRD68_01750 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) HRD68_01755 ENOG4105E5Z arginine transporter ATP-binding subunit HRD68_01760 ENOG4106PMH Extracellular solute-binding protein family 3 HRD68_01765 ENOG4105GBT ABC transporter HRD68_01770 ENOG4105DMR ABC, transporter HRD68_01775 ENOG4106TNF Periplasmic binding protein HRD68_01790 ENOG4105D38 putrescine abc transporter HRD68_01795 ENOG4105F38 ABC transporter, permease HRD68_01800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRD68_01805 ENOG4107RUE extracellular solute-binding protein family 1 HRD68_01810 ENOG4108RMJ sensory transduction regulator HRD68_01815 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HRD68_01820 ENOG41090BQ Glutaredoxin HRD68_01825 ENOG4105D0C transport protein HRD68_01840 ENOG4105DNE Transposase HRD68_01850 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HRD68_01855 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HRD68_01860 ENOG4107FB0 transcriptional regulator DeoR family HRD68_01865 ENOG4105C44 Serine transporter HRD68_01870 ENOG4105EJQ L-serine dehydratase HRD68_01875 ENOG4105DZ1 carboxypeptidase HRD68_01885 ENOG4105C28 cystathionine HRD68_01900 ENOG4108UMI ABC transporter, permease HRD68_01910 ENOG4105D01 (LipO)protein HRD68_01925 ENOG4108TGY Glutathione S-transferase HRD68_01930 ENOG4105D05 Receptor HRD68_01935 ENOG4108IQI permease HRD68_01940 ENOG4105DUM transcriptional regulator, lysR family HRD68_01950 ENOG4105HMI Membrane HRD68_01955 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HRD68_01960 ENOG4105DM4 PTS System HRD68_01965 ENOG4105DE4 1-phosphofructokinase HRD68_01970 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HRD68_01980 ENOG4105KRS Proteinase inhibitor HRD68_01990 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HRD68_02000 ENOG4105DEI Mannitol dehydrogenase HRD68_02005 ENOG4107YCY Transcriptional regulator HRD68_02015 ENOG4105CKI cobalamin synthesis protein HRD68_02020 ENOG41076MN Phosphoesterase, PA-phosphatase related HRD68_02025 ENOG4107TT5 NLP P60 protein HRD68_02030 ENOG4105CXC rtn protein HRD68_02035 ENOG4105E43 Extracellular solute-binding protein, family 5 HRD68_02040 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HRD68_02045 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HRD68_02050 ENOG4108JQ5 ABC transporter HRD68_02055 ENOG4105HG6 HRD68_02060 ENOG4105C2C drug resistance transporter, Bcr CflA HRD68_02065 ENOG4105I08 Pseudouridine synthase HRD68_02070 ENOG4105CFI type iii restriction protein res subunit HRD68_02080 ENOG4106V8H Nucleoid-associated protein HRD68_02085 ENOG4105PAN UPF0352 protein HRD68_02090 ENOG4105E68 Sulfatase HRD68_02115 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HRD68_02120 ENOG4108T65 Fimbrial HRD68_02125 ENOG4108SQA Fimbrial HRD68_02135 ENOG4108NAE Fimbrial chaperone protein HRD68_02140 ENOG4108RQP Major type 1 subunit fimbrin HRD68_02145 ENOG4105CS2 ec 3.2.1.21 HRD68_02150 ENOG4105C5Y PTS System HRD68_02155 ENOG4108Q3X Transcriptional regulator HRD68_02175 ENOG4108VEV chaperone HRD68_02185 ENOG4105Y50 Virulence Protein HRD68_02195 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_02205 ENOG4105CT4 transporter HRD68_02210 ENOG4107R6D beta-lactam binding protein AmpH HRD68_02225 ENOG4105FCK Membrane HRD68_02230 ENOG4107QZV Type I secretion membrane fusion protein HRD68_02235 ENOG4105BZ1 (ABC) transporter HRD68_02250 ENOG4106UW1 Major Facilitator superfamily HRD68_02255 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HRD68_02260 ENOG41068CG regulatoR HRD68_02265 ENOG4105BZU Histidine kinase HRD68_02270 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRD68_02280 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HRD68_02285 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HRD68_02290 ENOG4105XPH Ferredoxin HRD68_02295 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) HRD68_02305 ENOG4105E0U tyrosine-specific transport protein HRD68_02310 ENOG4108UII YfaZ family HRD68_02315 ENOG4105CH6 catalase HRD68_02320 ENOG4105CEY Amp-dependent synthetase and ligase HRD68_02325 ENOG4105DNI Converts SHCHC to OSB (By similarity) HRD68_02330 ENOG4108IPT Naphthoate synthase HRD68_02340 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HRD68_02345 ENOG4105E4F Isochorismate synthase HRD68_02355 ENOG4105TNS Conserved Protein HRD68_02360 ENOG4105C01 Dihydroxy-acid dehydratase HRD68_02365 ENOG41090KN UPF0303 protein HRD68_02375 ENOG4105C5I Dehydrogenase HRD68_02380 ENOG4105K2J Transcriptional regulator HRD68_02385 ENOG4105CHR reductase HRD68_02390 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HRD68_02395 ENOG4108R66 Conserved Protein HRD68_02400 ENOG4108UQ5 membrane protein YcdZ HRD68_02415 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRD68_02420 ENOG4105C8S subunit m HRD68_02425 ENOG4105D65 subunit l HRD68_02430 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRD68_02435 ENOG4107UFS subunit j HRD68_02440 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRD68_02445 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HRD68_02450 ENOG4108IEH NADH dehydrogenase subunit g HRD68_02455 ENOG4107QIZ NADH dehydrogenase HRD68_02460 ENOG4105GKE subunit e HRD68_02465 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRD68_02470 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRD68_02475 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HRD68_02480 ENOG4107NQ8 LysR family Transcriptional regulator HRD68_02485 ENOG4105CHM Aminotransferase HRD68_02490 ENOG4105DK2 UPF0207 protein HRD68_02495 ENOG4107QWE )-transporter HRD68_02505 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HRD68_02510 ENOG4105XWI UPF0304 protein HRD68_02515 ENOG4105PQ6 UPF0208 membrane protein HRD68_02525 ENOG4105C6K Malic enzyme HRD68_02530 ENOG4107P2S Transcriptional regulator HRD68_02535 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HRD68_02545 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HRD68_02555 ENOG4105E0C molybdate abc transporter HRD68_02560 ENOG4105Y50 Virulence Protein HRD68_02590 ENOG4105Y9F tail fiber protein HRD68_02595 ENOG4105Y0G tail protein HRD68_02600 ENOG4108T86 baseplate J family protein HRD68_02645 ENOG4105TKZ Tail Sheath HRD68_02695 ENOG4105CAR Terminase, large subunit HRD68_02740 ENOG4105CDU Replicative dna helicase HRD68_02745 ENOG4106CVF DNA replication protein HRD68_02885 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HRD68_02895 ENOG4105F4R Transcriptional regulator mode HRD68_02900 ENOG4105DKW ABC transporter HRD68_02910 ENOG4105CMR udp-glucose 4-epimerase HRD68_02915 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HRD68_02920 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HRD68_02925 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HRD68_02935 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HRD68_02940 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HRD68_02945 ENOG4105PGM cation diffusion facilitator family transporter HRD68_02950 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HRD68_02955 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HRD68_02985 ENOG4105UFD tol-pal system protein YbgF HRD68_02990 ENOG4105KCK Peptidoglycan-associated lipoprotein HRD68_02995 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HRD68_03000 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HRD68_03000 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HRD68_03010 ENOG4105E02 MotA TolQ exbB proton channel HRD68_03015 ENOG4107YD3 Thioesterase HRD68_03020 ENOG4105KJB cyd operon protein YbgE HRD68_03030 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HRD68_03035 ENOG4105C4M (Ubiquinol oxidase) subunit I HRD68_03040 ENOG4105CGH 5'-nucleotidase HRD68_03045 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HRD68_03055 ENOG4105C7S Dehydrogenase HRD68_03060 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HRD68_03065 ENOG4105E33 succinate dehydrogenase HRD68_03075 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HRD68_03080 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HRD68_03085 ENOG4105BZN citrate synthase HRD68_03105 ENOG4105E7W lamb ycsf family protein HRD68_03110 ENOG4107R7A Allophanate hydrolase subunit 2 HRD68_03115 ENOG4105P4J Allophanate hydrolase, subunit 1 HRD68_03120 ENOG4107QNR UPF0135 protein HRD68_03125 ENOG4107RF4 Phosphodiesterase HRD68_03130 ENOG4105CVP deoxyribo-dipyrimidine photolyase HRD68_03135 ENOG4107SEY Conserved Protein HRD68_03140 ENOG4105XIQ Protein of unknown function (DUF2517) HRD68_03150 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HRD68_03155 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HRD68_03160 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HRD68_03165 ENOG4105C08 Histidine kinase HRD68_03170 ENOG4105EEX Two component transcriptional regulator (Winged helix family HRD68_03180 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HRD68_03190 ENOG4105EV9 Alpha Beta Hydrolase HRD68_03195 ENOG4105NNH LexA regulated protein HRD68_03200 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_03205 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HRD68_03210 ENOG41090R7 Ferric uptake HRD68_03225 ENOG4105GX6 (LipO)protein HRD68_03235 ENOG4105CX6 glutaminyL-tRNA synthetase HRD68_03240 ENOG4105CI1 PTS System HRD68_03250 ENOG4105CE4 GlcNAc 6-P deacetylase HRD68_03255 ENOG4105E2R ROK family HRD68_03260 ENOG4105D4U had-superfamily hydrolase, subfamily iia HRD68_03265 ENOG4105CAQ asparagine synthetase HRD68_03300 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HRD68_03305 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HRD68_03310 ENOG4105C9A Phoh family HRD68_03315 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HRD68_03320 ENOG4108JU5 Magnesium and cobalt efflux protein HRD68_03325 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HRD68_03335 ENOG4107RP9 extracellular solute-binding protein, family 3 HRD68_03340 ENOG4105EAD ABC transporter HRD68_03345 ENOG4105DRP amino acid AbC transporter HRD68_03350 ENOG4105CDA abc transporter atp-binding protein HRD68_03355 ENOG4107PAI alpha helical protein HRD68_03365 ENOG4108U2H Rare lipoprotein B HRD68_03370 ENOG4105DJF DNA polymerase III, delta' subunit HRD68_03375 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HRD68_03380 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HRD68_03390 ENOG4105CJN penicillin-binding protein HRD68_03395 ENOG4105CNI cell division protein FtsW HRD68_03400 ENOG4105K6T rare lipoprotein A HRD68_03405 ENOG4105DZ1 carboxypeptidase HRD68_03410 ENOG4108Z43 UPF0250 protein HRD68_03415 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HRD68_03420 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HRD68_03425 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HRD68_03430 ENOG4105BZU Histidine kinase HRD68_03450 ENOG4108N8T regulatoR HRD68_03460 ENOG4108R1E Serine threonine protein phosphatase 1 HRD68_03475 ENOG4108JJ7 ABC transporter HRD68_03485 ENOG4105EZE Cupin 4 family protein HRD68_03495 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HRD68_03500 ENOG4107QPK )-transporter HRD68_03510 ENOG4108Q2J Inner membrane protein YebE HRD68_03520 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HRD68_03525 ENOG4105D7K pfkb domain protein HRD68_03530 ENOG4108HKT sucrose-6-phosphate hydrolase HRD68_03535 ENOG4106NDP Transcriptional regulator HRD68_03550 ENOG4105DD7 kinase (PfkB family HRD68_03555 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HRD68_03560 ENOG4105D9N nucleoside HRD68_03585 ENOG410822N TonB family HRD68_03605 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HRD68_03625 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HRD68_03630 ENOG4105WQ3 Rna-binding protein HRD68_03650 ENOG4105UGQ Fimbrial HRD68_03660 ENOG4108FZ9 Chaperone HRD68_03665 ENOG4106PG1 outer membrane usher protein HRD68_03685 ENOG4105C8N cysteinyl-tRNA synthetase HRD68_03690 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HRD68_03695 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HRD68_03700 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HRD68_03705 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HRD68_03710 ENOG4105CV6 ABC transporter, permease HRD68_03715 ENOG4108I0Y (ABC) transporter HRD68_03720 ENOG4108UJV acyl-CoA thioesterase i HRD68_03725 ENOG4105E1F short-chain dehydrogenase reductase HRD68_03730 ENOG4107QR8 Thioredoxin HRD68_03735 ENOG4107QX8 SPFH domain, Band 7 family protein HRD68_03740 ENOG4105G5H Membrane HRD68_03750 ENOG4105C59 p-type ATPase HRD68_03755 ENOG4105MBR gumn family HRD68_03760 ENOG4108Z66 YbaK ebsC protein HRD68_03765 ENOG4105CGH 5'-nucleotidase HRD68_03770 ENOG4105EU0 Major facilitator Superfamily HRD68_03775 ENOG4105CKD glutathione-regulated potassium-efflux system protein HRD68_03780 ENOG4107RE1 Inosine-guanosine kinase HRD68_03785 ENOG4108QY5 Ferric enterobactin transport protein HRD68_03790 ENOG4105CMR udp-glucose 4-epimerase HRD68_03800 ENOG4105DMT epimerase dehydratase HRD68_03825 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HRD68_03830 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HRD68_03835 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HRD68_03840 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HRD68_03850 ENOG4107QMP dna polymerase iii subunits gamma and tau HRD68_03855 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HRD68_03860 ENOG4105WD1 Membrane HRD68_03870 ENOG4106428 Protein of unknown function (DUF2496) HRD68_03875 ENOG4105EGS Mechanosensitive ion channel HRD68_03880 ENOG41090EX DsrE family HRD68_03885 ENOG4107XI7 Tetr family transcriptional regulator HRD68_03890 ENOG4105C1P efflux transporter, rnd family, mfp subunit HRD68_03895 ENOG4105BZS acriflavin resistance protein HRD68_03900 ENOG4105RMW regulation of transcription, DNA-dependent HRD68_03905 ENOG4108626 Racemase HRD68_03910 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HRD68_03915 ENOG4105NRA 50s ribosomal protein l31 type b HRD68_03920 ENOG4105YK5 50S ribosomal protein L36 HRD68_03925 ENOG4105DSE periplasmic solute binding protein HRD68_03930 ENOG4105CC5 ABC transporter HRD68_03935 ENOG4105DIK (ABC) transporter HRD68_03945 ENOG4108UKR Biofilm formation regulator YbaJ HRD68_03950 ENOG4105KF5 hemolysin expression-modulating protein HRD68_03970 ENOG41080UX Methyltransferase HRD68_03975 ENOG4108MNP Glycoprotein polysaccharide metabolism HRD68_03980 ENOG4105C29 acyl-CoA thioesterase HRD68_03985 ENOG4105BZU Histidine kinase HRD68_03990 ENOG4108YZA Nitrogen regulatory protein pii HRD68_03995 ENOG4105BZ1 (ABC) transporter HRD68_04000 ENOG4105BZ1 (ABC) transporter HRD68_04005 ENOG4108XM1 transcriptional regulator AsnC family HRD68_04015 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HRD68_04020 ENOG4108NFA extracellular solute-binding protein HRD68_04025 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HRD68_04030 ENOG4108TGP Thioesterase superfamily protein HRD68_04035 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HRD68_04040 ENOG4105EIN peptidylprolyl cis-trans isomerase HRD68_04045 ENOG4105K70 DNA-binding protein HRD68_04050 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HRD68_04055 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HRD68_04060 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HRD68_04065 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HRD68_04070 ENOG4105M85 Bola protein HRD68_04075 ENOG4105IEY (LipO)protein HRD68_04080 ENOG4105EYM Major Facilitator superfamily HRD68_04085 ENOG4108NFH Sugar hydrolase HRD68_04090 ENOG4105E2S oxidase) subunit II HRD68_04095 ENOG4105BZ9 Cytochrome C oxidase, subunit I HRD68_04100 ENOG4105CCU oxidase (Subunit III) HRD68_04105 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HRD68_04110 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HRD68_04115 ENOG4107RDB Major Facilitator HRD68_04120 ENOG4108VPT UPF0234 protein HRD68_04125 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HRD68_04130 ENOG4107S0N DJ-1 family HRD68_04135 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HRD68_04145 ENOG4105CTB Polyprenyl synthetase HRD68_04150 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HRD68_04155 ENOG4108ZAI phosphatidylglycerophosphatase a HRD68_04160 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HRD68_04175 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HRD68_04180 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HRD68_04190 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HRD68_04195 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HRD68_04200 ENOG4105VIE preprotein translocase, subunit YajC HRD68_04205 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HRD68_04215 ENOG4108ZYK Acyl carrier protein phosphodiesterase HRD68_04220 ENOG4105D3R alkyl hydroperoxide reductase HRD68_04230 ENOG4105CHR reductase HRD68_04235 ENOG4107R28 alpha amylase, catalytic region HRD68_04240 ENOG4105C85 amino acid HRD68_04245 ENOG4105CWM branched-chain amino acid transport system II carrier protein HRD68_04250 ENOG4105DJH phosphate HRD68_04255 ENOG4105BZU Histidine kinase HRD68_04260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HRD68_04265 ENOG4107RH8 nuclease SbcCD subunit D HRD68_04270 ENOG4105EYH Exonuclease HRD68_04275 ENOG4105DKQ ROK family HRD68_04280 ENOG4105DH7 May be involved in recombination (By similarity) HRD68_04285 ENOG4105NBK UPF0345 protein HRD68_04290 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HRD68_04305 ENOG4105F2W methyltransferase HRD68_04320 ENOG4105E2V Glycosyltransferase 36 HRD68_04330 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HRD68_04335 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HRD68_04340 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HRD68_04345 ENOG4105V1F Fermentation respiration switch protein HRD68_04355 ENOG4105CIN aminoacyl-histidine dipeptidase HRD68_04360 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HRD68_04375 ENOG4105CJ2 (LipO)protein HRD68_04380 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HRD68_04385 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRD68_04390 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRD68_04395 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRD68_04400 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRD68_04405 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HRD68_04410 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HRD68_04415 ENOG4105E7A Glutamine amidotransferase HRD68_04425 ENOG4107QPN acyl-Coa dehydrogenase HRD68_04430 ENOG4106YJS accessory processing protein HRD68_04445 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HRD68_04455 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HRD68_04465 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HRD68_04470 ENOG4105CHM Aminotransferase HRD68_04480 ENOG4105C5R Aminotransferase HRD68_04485 ENOG4105EQ0 Major Facilitator superfamily HRD68_04490 ENOG4108UMN azlc family HRD68_04495 ENOG4105ZED uncharacterized protein ygaH HRD68_04500 ENOG4105NTK Transcriptional repressor Mpra HRD68_04510 ENOG4105CW7 secretion protein, HlyD family HRD68_04515 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRD68_04520 ENOG4105EIB trna rrna methyltransferase HRD68_04525 ENOG4105K63 Thioredoxin HRD68_04530 ENOG4106IUH DTW domain containing protein HRD68_04535 ENOG4105CD5 CoA-binding domain protein HRD68_04540 ENOG4105JIM Phosphatidylserine synthase HRD68_04570 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HRD68_04575 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HRD68_04580 ENOG4105C34 Pseudouridine synthase HRD68_04585 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HRD68_04590 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HRD68_04595 ENOG4105CQC Prephenate dehydratase HRD68_04600 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HRD68_04605 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HRD68_04610 ENOG4108NEV two component transcriptional regulator, LytTR family HRD68_04615 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HRD68_04620 ENOG4108NE3 Salt-induced outer membrane protein HRD68_04625 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HRD68_04635 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HRD68_04645 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HRD68_04650 ENOG4106KVJ cytochrome C assembly protein HRD68_04655 ENOG4108JU6 CBS domain protein HRD68_04660 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HRD68_04665 ENOG4105D9M gamma-glutamylcysteine synthetase HRD68_04670 ENOG4105W39 Membrane HRD68_04675 ENOG4107VXZ Hydrolase HRD68_04705 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HRD68_04710 ENOG4105Y3E Modulates RecA activity (By similarity) HRD68_04715 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HRD68_04740 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HRD68_04745 ENOG4108IUS Transketolase HRD68_04750 ENOG4108HHA Transketolase HRD68_04755 ENOG4105CNN ABC, transporter HRD68_04760 ENOG4105C2J ABC transporter HRD68_04785 ENOG4108NEM leader-binding protein dmsD HRD68_04790 ENOG4107KGK dmso reductase anchor subunit HRD68_04795 ENOG4105QAX Iron-sulfur HRD68_04800 ENOG4107QY8 reductase HRD68_04805 ENOG4105C0A alcohol dehydrogenase HRD68_04810 ENOG4107W7X Aldolase HRD68_04815 ENOG4105EDR glucose galactose transporter HRD68_04825 ENOG4105CMG Carbohydrate kinase HRD68_04835 ENOG4107EDW L-fucose operon activator HRD68_04840 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HRD68_04845 ENOG4105E98 transcriptional regulator DeoR family HRD68_04855 ENOG4105C2J ABC transporter HRD68_04860 ENOG4105CNN ABC, transporter HRD68_04870 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HRD68_04875 ENOG4105CMG Carbohydrate kinase HRD68_04880 ENOG4107GFK fumarate HRD68_04890 ENOG4105C32 Amino acid ABC transporter (Permease) HRD68_04895 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HRD68_04900 ENOG4108IUZ ABC transporter HRD68_04905 ENOG4108IV0 ABC, transporter HRD68_04930 ENOG4105DKT Transcriptional regulator HRD68_04935 ENOG4108XCU pts system HRD68_04940 ENOG4105KPI PTS system sorbose subfamily IIB component HRD68_04945 ENOG4105ETZ PTS System HRD68_04950 ENOG4105F3R pts system mannose fructose sorbose family iid HRD68_04955 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HRD68_04960 ENOG4105YVS arsR family transcriptional regulator HRD68_04965 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HRD68_04980 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HRD68_04985 ENOG4105CDA abc transporter atp-binding protein HRD68_04990 ENOG4105E5Q amino acid AbC transporter HRD68_04995 ENOG4105E5Q amino acid AbC transporter HRD68_05000 ENOG4105EAB amino acid AbC transporter HRD68_05005 ENOG4105BZC d-serine deaminase HRD68_05010 ENOG4105C6Z Gluconate HRD68_05015 ENOG4105W8I Transcriptional regulator HRD68_05020 ENOG4108JQ7 (ABC) transporter HRD68_05030 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRD68_05035 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRD68_05040 ENOG4105DEF Extracellular solute-binding protein, family 5 HRD68_05045 ENOG4105CXK mandelate racemase muconate lactonizing HRD68_05050 ENOG4105CIH Imidazole acetol-phosphate transaminase HRD68_05055 ENOG4105F87 Dehydratase HRD68_05065 ENOG4105CHR reductase HRD68_05080 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRD68_05085 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HRD68_05090 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HRD68_05095 ENOG4105DJY efflux transporter, rnd family, mfp subunit HRD68_05100 ENOG4108JJA ABC, transporter HRD68_05125 ENOG4105H8W Fimbrial protein HRD68_05130 ENOG4105NEV Fimbrial HRD68_05145 ENOG4108FZ9 Chaperone HRD68_05150 ENOG4106PG1 outer membrane usher protein HRD68_05175 ENOG4105EHZ conserved protein UCP016719 HRD68_05185 ENOG4105D17 glycoside hydrolase, family 3 domain protein HRD68_05190 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) HRD68_05195 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HRD68_05200 ENOG4105C5Y PTS System HRD68_05210 ENOG4105CW0 outer membrane usher protein HRD68_05215 ENOG4108VCD Chaperone HRD68_05220 ENOG4108VCD Chaperone HRD68_05230 ENOG4108VCD Chaperone HRD68_05245 ENOG4105C28 cystathionine HRD68_05255 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HRD68_05260 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRD68_05265 ENOG4108K5P (LipO)protein HRD68_05270 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HRD68_05275 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HRD68_05280 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HRD68_05285 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HRD68_05295 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HRD68_05300 ENOG4106PMH Extracellular solute-binding protein family 3 HRD68_05305 ENOG4105DRP amino acid AbC transporter HRD68_05315 ENOG4105N0Z inner membrane protein ygbE HRD68_05320 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HRD68_05325 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HRD68_05330 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HRD68_05335 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HRD68_05340 ENOG4108MXK alkaline phosphatase isozyme conversion HRD68_05345 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HRD68_05350 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HRD68_05355 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HRD68_05360 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HRD68_05365 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HRD68_05380 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HRD68_05385 ENOG4105DXN mazG family HRD68_05390 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HRD68_05395 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HRD68_05400 ENOG4105BZU Histidine kinase HRD68_05405 ENOG4105C0H protease HRD68_05410 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HRD68_05415 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HRD68_05425 ENOG4105EN6 Membrane HRD68_05435 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HRD68_05445 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HRD68_05450 ENOG4105S6R Iron-hydroxamate transporter permease subunit HRD68_05455 ENOG4105J76 Periplasmic binding protein HRD68_05460 ENOG4105E0A ABC, transporter HRD68_05465 ENOG4105BZ4 penicillin-binding protein HRD68_05470 ENOG4105CQ7 ATP-dependent helicase HRD68_05475 ENOG4107XID 2'-5' rna ligase HRD68_05485 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HRD68_05495 ENOG4105DJ0 Poly(A) Polymerase HRD68_05500 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HRD68_05505 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HRD68_05510 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HRD68_05515 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HRD68_05520 ENOG4107BJW polysaccharide deacetylase HRD68_05525 ENOG4105E3A (ABC) transporter HRD68_05530 ENOG4105DA5 (ABC) transporter HRD68_05535 ENOG41077A9 carbonic anhydrase HRD68_05540 ENOG4108UGV hypoxanthine phosphoribosyltransferase HRD68_05550 ENOG4105E3B Multicopper oxidase HRD68_05555 ENOG4108ZRK uncharacterized protein yacC HRD68_05560 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HRD68_05575 ENOG4108ZIG UPF0231 protein HRD68_05580 ENOG4107QIJ Aconitate hydratase 2 HRD68_05585 ENOG4107RNH Outer membrane receptor FepA HRD68_05595 ENOG4107QN2 dihydrolipoyl dehydrogenase HRD68_05600 ENOG4107QSN dihydrolipoamide acetyltransferase HRD68_05605 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HRD68_05610 ENOG41073TP transcriptional regulator HRD68_05615 ENOG4105C85 amino acid HRD68_05625 ENOG4106A72 regulatory protein AmpE HRD68_05630 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HRD68_05635 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HRD68_05640 ENOG4108ZUW Major pilin subunit HRD68_05645 ENOG4107QHF type ii secretion system protein e HRD68_05650 ENOG4105D7Q type ii secretion system HRD68_05655 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HRD68_05670 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HRD68_05675 ENOG4105M6F mutator MutT protein HRD68_05680 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HRD68_05685 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HRD68_05700 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HRD68_05705 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HRD68_05710 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HRD68_05720 ENOG4105DFU Cell wall formation (By similarity) HRD68_05725 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HRD68_05730 ENOG4105CNI cell division protein FtsW HRD68_05740 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HRD68_05745 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HRD68_05750 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HRD68_05755 ENOG4105CJN penicillin-binding protein HRD68_05760 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HRD68_05765 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HRD68_05780 ENOG4107B7Y DNA-binding transcriptional regulator FruR HRD68_05785 ENOG4108ZP8 Acetolactate synthase small subunit HRD68_05790 ENOG4105C7K acetolactate synthase HRD68_05795 ENOG4108IQE Amp-dependent synthetase and ligase HRD68_05800 ENOG41064T2 transcriptional regulator, lysR family HRD68_05815 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HRD68_05820 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HRD68_05835 ENOG4105C0F tryptophanase EC 4.1.99.1 HRD68_05840 ENOG4105CIC tryptophan-specific transport protein HRD68_05845 ENOG4105S8Q sugar efflux transporter HRD68_05855 ENOG4105F1A Pyruvate formate-lyase HRD68_05860 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HRD68_05865 ENOG4105DP9 ABC transporter HRD68_05870 ENOG4106SMU thiamine transporter membrane protein HRD68_05875 ENOG4107T0D ABC, transporter HRD68_05880 ENOG4108KF1 Membrane HRD68_05885 ENOG4105CQ2 DNA polymerase HRD68_05895 ENOG4105Q26 Siderophore-interacting protein HRD68_05915 ENOG4105DUU IucA IucC family protein HRD68_05920 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HRD68_05930 ENOG4105D3G Pseudouridine synthase HRD68_05940 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HRD68_05945 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HRD68_05960 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HRD68_05965 ENOG4105NWN ApaG protein HRD68_05970 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HRD68_05975 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HRD68_05985 ENOG4105DWK Membrane HRD68_05990 ENOG4105N14 lysine exporter protein LysE YggA HRD68_05995 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HRD68_06010 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HRD68_06015 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HRD68_06025 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HRD68_06030 ENOG4105DTN riboflavin biosynthesis protein ribF HRD68_06050 ENOG41063Z6 transcriptional regulator, lysR family HRD68_06055 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HRD68_06065 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HRD68_06075 ENOG4106HK8 GPR1 FUN34 yaaH family protein HRD68_06085 ENOG4105CSH Transporter HRD68_06090 ENOG4108RIR Molybdenum cofactor biosynthesis protein HRD68_06095 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HRD68_06100 ENOG4105D1Q UPF0246 protein HRD68_06110 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HRD68_06125 ENOG41065U4 response regulator HRD68_06130 ENOG4108RH0 Crea protein HRD68_06135 ENOG4105UEI Transcriptional Regulator AraC Family HRD68_06140 ENOG4105CVJ phosphoglycerate mutase HRD68_06145 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HRD68_06150 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HRD68_06155 ENOG4107SC1 transglycosylase HRD68_06170 ENOG4108KHX Diguanylate cyclase HRD68_06175 ENOG41090EK ompa motb domain protein HRD68_06180 ENOG4105C5H ABC transporter HRD68_06215 ENOG4105C0A alcohol dehydrogenase HRD68_06230 ENOG4105CIS alcohol dehydrogenase HRD68_06235 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HRD68_06240 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HRD68_06245 ENOG4105EAC phosphoserine phosphatase HRD68_06250 ENOG41062Z9 Membrane HRD68_06255 ENOG4105K4U addiction module toxin, RelE StbE family HRD68_06270 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HRD68_06285 ENOG4105D9N nucleoside HRD68_06290 ENOG4105EYA deoxyribonuclease HRD68_06295 ENOG4108NRW Phospholipase, patatin family HRD68_06305 ENOG4105K3G Periplasmic Protein HRD68_06310 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HRD68_06315 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HRD68_06320 ENOG4108WPU DNA polymerase III subunit psi HRD68_06325 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HRD68_06330 ENOG4105CPC Aldo Keto reductase HRD68_06355 ENOG4105YBH Protein of unknown function (DUF1435) HRD68_06360 ENOG4105BZU Histidine kinase HRD68_06365 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HRD68_06375 ENOG4106UW1 Major Facilitator superfamily HRD68_06400 ENOG4105VDH Dihydroxyacetone kinase HRD68_06405 ENOG4108UTZ Dihydroxyacetone kinase HRD68_06410 ENOG4105CMT Dihydroxyacetone kinase HRD68_06420 ENOG4105BZS acriflavin resistance protein HRD68_06425 ENOG410624X efflux transporter, rnd family, mfp subunit HRD68_06430 ENOG4105CEU Arginine dihydrolase HRD68_06435 ENOG4105D5Q Arginine ornithine antiporter HRD68_06445 ENOG4105DKP glycosyl transferase, family 9 HRD68_06450 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HRD68_06455 ENOG4105DKT Transcriptional regulator HRD68_06460 ENOG4105C2J ABC transporter HRD68_06465 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HRD68_06470 ENOG4105F5R ABC transporter HRD68_06480 ENOG41061GT Aldolase HRD68_06490 ENOG4105RI1 glycoprotein receptor HRD68_06495 ENOG4105CAF HipA N-terminal domain protein HRD68_06500 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HRD68_06530 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HRD68_06535 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HRD68_06540 ENOG4106549 Antirestriction protein HRD68_06545 ENOG4106H6R UPF0380 protein HRD68_06595 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HRD68_06650 ENOG4108K5H permease YjgP YjgQ family protein HRD68_06655 ENOG4108M8S permease YjgP YjgQ family protein HRD68_06660 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HRD68_06665 ENOG4105MYG DNA polymerase iii, chi subunit HRD68_06675 ENOG4108MJ3 acetyltransferase HRD68_06680 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HRD68_06690 ENOG4105XEP YhcH YjgK YiaL family protein HRD68_06700 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRD68_06705 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRD68_06710 ENOG4105C3U ABC transporter HRD68_06715 ENOG4108JQ7 (ABC) transporter HRD68_06730 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HRD68_06735 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HRD68_06750 ENOG4107RJJ Transcriptional regulator HRD68_06755 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HRD68_06760 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HRD68_06765 ENOG4105EKV Phosphonate metabolism protein HRD68_06770 ENOG4105FT8 Phosphonate metabolism HRD68_06775 ENOG4105ENV phosphonate C-P lyase system protein PhnK HRD68_06780 ENOG4105HRV phosphonate c-p lyase system protein phnl HRD68_06785 ENOG4105FD8 phosphonate metabolism protein PhnM HRD68_06790 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HRD68_06795 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HRD68_06800 ENOG4105K4T epimerase HRD68_06820 ENOG4105DRS transport system, permease HRD68_06840 ENOG4105EY3 heparinase II III family protein HRD68_06850 ENOG4105CXN decarboxylase HRD68_06855 ENOG4105D5Q Arginine ornithine antiporter HRD68_06865 ENOG4108YYD acetyltransferase HRD68_06885 ENOG4105CEM UPF0597 protein HRD68_06890 ENOG4105C44 Serine transporter HRD68_06895 ENOG4105DEN Luciferase family HRD68_06900 ENOG4105C1J atp-dependent rna helicase HRD68_06915 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HRD68_06925 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HRD68_06930 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HRD68_06940 ENOG4105CHV Transcription elongation factor NusA HRD68_06960 ENOG4105NTZ Preprotein translocase subunit SecG HRD68_06970 ENOG4105EEI dihydropteroate synthase HRD68_06975 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HRD68_06980 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HRD68_06985 ENOG4105HBR Rna-binding protein HRD68_06995 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HRD68_07010 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HRD68_07015 ENOG4105QYV Membrane HRD68_07020 ENOG4105K46 50S ribosomal protein l27 HRD68_07030 ENOG4105EAH synthase HRD68_07040 ENOG4105HVQ Regulatory factor of maltose metabolism HRD68_07060 ENOG4105DFU Cell wall formation (By similarity) HRD68_07070 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_07075 ENOG4105F0N pyrophosphate phospho-hydrolase HRD68_07080 ENOG4108ZHD aig2 family HRD68_07085 ENOG4105MA0 exported protein HRD68_07095 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HRD68_07100 ENOG4105C37 (CBS) domain HRD68_07105 ENOG41061GZ Protein of unknown function (DUF1107) HRD68_07110 ENOG4108UUE Transcriptional regulator HRD68_07115 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HRD68_07120 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HRD68_07130 ENOG4108V1T peptidylprolyl cis-trans isomerase HRD68_07135 ENOG4105FHY Opacity-associated protein A HRD68_07145 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HRD68_07160 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HRD68_07165 ENOG4105RID UPF0379 protein yhcN HRD68_07170 ENOG4108MXZ Esterase HRD68_07175 ENOG4105WSB biofilm stress and motility protein A HRD68_07180 ENOG4105CSU acyl-Coa dehydrogenase HRD68_07185 ENOG4105C2N RNA methyltransferase TrmH family group 3 HRD68_07190 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HRD68_07195 ENOG4105KPV Transcriptional regulator HRD68_07210 ENOG4105EPW hflc protein HRD68_07215 ENOG4107QJR hflk protein HRD68_07220 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HRD68_07230 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HRD68_07240 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HRD68_07245 ENOG4105K8N protein family UPF0079, ATPase HRD68_07250 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HRD68_07255 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HRD68_07275 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HRD68_07280 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HRD68_07285 ENOG4105DJ4 phosphatidylserine decarboxylase HRD68_07290 ENOG4105EGS Mechanosensitive ion channel HRD68_07310 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HRD68_07315 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HRD68_07335 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HRD68_07340 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HRD68_07345 ENOG4108ZVF (LipO)protein HRD68_07350 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HRD68_07355 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HRD68_07370 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HRD68_07380 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HRD68_07385 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HRD68_07390 ENOG4105BZ8 glutamate synthase HRD68_07395 ENOG4105BZ8 glutamate synthase HRD68_07400 ENOG4105DJB Major Facilitator Superfamily HRD68_07405 ENOG4105BZW Glycerate kinase HRD68_07410 ENOG4105CTX dehydratase HRD68_07415 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HRD68_07420 ENOG4105BZW Glycerate kinase HRD68_07425 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HRD68_07430 ENOG4105CNV Aldolase HRD68_07435 ENOG4108SIC Transcriptional regulator HRD68_07445 ENOG4108EX3 reductase HRD68_07450 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HRD68_07455 ENOG4105FAW cDP-glucose 4,6-dehydratase HRD68_07460 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HRD68_07495 ENOG4105D1F ATP-binding protein HRD68_07505 ENOG4107EEX Cellulose synthase regulator protein HRD68_07510 ENOG4105EJG cellulose synthase HRD68_07520 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HRD68_07525 ENOG4105D4P Coproporphyrinogen iii oxidase HRD68_07530 ENOG41090JE Utilization Protein HRD68_07540 ENOG4107F3C Hemin uptake protein HRD68_07545 ENOG4107ENK receptor HRD68_07550 ENOG4106QJH hemin transport protein HRD68_07555 ENOG4107R4I Periplasmic binding protein HRD68_07560 ENOG4105EHG Permease protein HRD68_07565 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HRD68_07570 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HRD68_07580 ENOG4105E0K tonB-dependent siderophore receptor HRD68_07585 ENOG4105EGS Mechanosensitive ion channel HRD68_07625 ENOG4108TN6 type iii secretion HRD68_07630 ENOG4105U07 type iii secretion HRD68_07635 ENOG41075IY surface presentation of antigens protein SpaP HRD68_07655 ENOG4108JIR Flagellum-specific ATP synthase HRD68_07665 ENOG4108HR8 type iii secretion HRD68_07670 ENOG4105X27 type iii secretion HRD68_07680 ENOG4108KB1 transcriptional regulator, arac family HRD68_07700 ENOG4108RBT type iii secretion HRD68_07720 ENOG4105FTC Lytic transglycosylase catalytic HRD68_07735 ENOG4105WH1 Two component transcriptional regulator luxr family HRD68_07740 ENOG4108FKE two-component system sensor kinase HRD68_07780 ENOG4107QHF type ii secretion system protein e HRD68_07785 ENOG4105D7Q type ii secretion system HRD68_07800 ENOG4105X5Z General secretion pathway protein I HRD68_07825 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HRD68_07835 ENOG4108M1A Chitin-binding protein HRD68_07845 ENOG4107RAN Peptidase, M16 HRD68_07850 ENOG4105CQ0 ABC transporter HRD68_07855 ENOG4105PE1 Receptor HRD68_07860 ENOG4108S3W Anti-feci sigma factor, fecr HRD68_07865 ENOG4108SF5 RNA Polymerase HRD68_07880 ENOG4105VDM plasmid maintenance system antidote protein, xre family HRD68_07890 ENOG41066VF YeeE YedE family protein HRD68_07895 ENOG4108IUF type iii secretion HRD68_07900 ENOG4108TN6 type iii secretion HRD68_07905 ENOG41083GP type iii secretion HRD68_07910 ENOG4108HHI Type III secretion system protein HRD68_07930 ENOG4108JIR Flagellum-specific ATP synthase HRD68_07940 ENOG4106H1D secretion system apparatus protein HRD68_07945 ENOG4105UQF type iii secretion HRD68_08000 ENOG4106FZW pathogenicity island effector protein HRD68_08005 ENOG4108SZ7 secretion system effector HRD68_08015 ENOG4105ZQI secreted protein HRD68_08045 ENOG4105BZU Histidine kinase HRD68_08055 ENOG4105CK2 sodium dicarboxylate symporter HRD68_08060 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HRD68_08065 ENOG41062QD Membrane HRD68_08070 ENOG4107QN1 sodium solute HRD68_08115 ENOG4105C12 Phosphoribosylglycinamide synthetase HRD68_08120 ENOG4108T8B Protein of unknown function (DUF1481) HRD68_08130 ENOG4105R2J Conserved Protein HRD68_08135 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HRD68_08145 ENOG4105E09 nadh pyrophosphatase HRD68_08150 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor HRD68_08165 ENOG4105D06 uba thif-type nad fad binding protein HRD68_08170 ENOG4105WHD thiamine biosynthesis protein ThiS HRD68_08180 ENOG4105D41 biosynthesis protein thiH HRD68_08185 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HRD68_08190 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HRD68_08195 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HRD68_08200 ENOG4108VZM 50s ribosomal protein L10 HRD68_08210 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HRD68_08215 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HRD68_08220 ENOG4105PM1 preprotein translocase subunit SecE HRD68_08255 ENOG4105CS9 pantothenic acid kinase HRD68_08260 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HRD68_08290 ENOG4108RR8 protoporphyrinogen oxidase HRD68_08295 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HRD68_08300 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HRD68_08310 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HRD68_08315 ENOG4105CHU acetyl-coa acetyltransferase HRD68_08320 ENOG4107QK7 reductase HRD68_08325 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HRD68_08330 ENOG4105MDZ Transcriptional activator rfaH HRD68_08335 ENOG4105D52 delta-aminolevulinic acid dehydratase HRD68_08345 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HRD68_08355 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HRD68_08360 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HRD68_08365 ENOG4105JC1 sterol-binding domain protein HRD68_08370 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HRD68_08375 ENOG4105CGY Dna recombination protein HRD68_08380 ENOG4108KF1 Membrane HRD68_08395 ENOG4107SXA Phosphorylase HRD68_08400 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HRD68_08405 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HRD68_08410 ENOG4105DZ2 Transcriptional regulator HRD68_08415 ENOG4105EMK carboxylate amino acid amine transporter HRD68_08420 ENOG4105RK9 auxin efflux carrier HRD68_08425 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HRD68_08430 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRD68_08435 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HRD68_08440 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HRD68_08445 ENOG4105BZ7 extracellular solute-binding protein family 1 HRD68_08480 ENOG4108IV0 ABC, transporter HRD68_08485 ENOG4105C0Z ABC transporter HRD68_08490 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HRD68_08495 ENOG4105C32 Amino acid ABC transporter (Permease) HRD68_08500 ENOG4105CP9 extracellular ligand-binding receptor HRD68_08505 ENOG4105U59 -acetyltransferase HRD68_08515 ENOG4105CRP Part of the ABC transporter FtsEX involved in HRD68_08520 ENOG4105CAK Cell division ATP-binding protein ftsE HRD68_08525 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HRD68_08525 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HRD68_08530 ENOG4106H78 methyltransferase HRD68_08535 ENOG4105MG3 Membrane HRD68_08550 ENOG4107FS9 Membrane HRD68_08560 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HRD68_08565 ENOG4105EX9 Membrane HRD68_08570 ENOG4108W1V Lipoprotein HRD68_08575 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HRD68_08585 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HRD68_08590 ENOG4105CXY transporter HRD68_08595 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HRD68_08600 ENOG4105DQF Hydrolase HRD68_08605 ENOG4108EUD Lysophospholipase HRD68_08610 ENOG410829K Lysine exporter protein (Lyse ygga) HRD68_08615 ENOG4105CCF Lysine exporter protein (Lyse ygga) HRD68_08620 ENOG4105C9U ATP-dependent DNA helicase RecQ HRD68_08625 ENOG4105HDD phospholipase HRD68_08630 ENOG4108VUY thioesterase Superfamily protein HRD68_08635 ENOG4105FR1 rard protein HRD68_08660 ENOG4105C4R Atp-dependent dna helicase HRD68_08665 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HRD68_08670 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HRD68_08675 ENOG4105CT0 Protein of unknown function, DUF484 HRD68_08680 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HRD68_08685 ENOG4105S7Z (LipO)protein HRD68_08700 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HRD68_08705 ENOG41076E6 Uroporphyrinogen-III Synthase HRD68_08710 ENOG4105ECF c-methyltransferase HRD68_08715 ENOG410601J HemY protein HRD68_08740 ENOG4105C85 amino acid HRD68_08755 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HRD68_08760 ENOG4105EGZ biosynthesis protein HRD68_08765 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HRD68_08770 ENOG4108WJ1 acetyltransferase HRD68_08775 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HRD68_08780 ENOG4105C1B dTDP-glucose 4-6-dehydratase HRD68_08785 ENOG4108IJ1 Dehydrogenase HRD68_08790 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HRD68_08795 ENOG4105SFE lipopolysaccharide biosynthesis protein HRD68_08800 ENOG4105ESV Glycosyl transferase, family 4 HRD68_08805 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HRD68_08820 ENOG4105C9X ppx gppa phosphatase HRD68_08830 ENOG4105C4R Atp-dependent dna helicase HRD68_08835 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HRD68_08845 ENOG4108MQF Chaperone HRD68_08850 ENOG4105CW0 outer membrane usher protein HRD68_08860 ENOG4108VEV chaperone HRD68_08865 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HRD68_08870 ENOG4105EMY transcriptional regulator HRD68_08880 ENOG4105C7B Threonine dehydratase HRD68_08885 ENOG4105C01 Dihydroxy-acid dehydratase HRD68_08890 ENOG4105CM2 brancheD-chain amino acid aminotransferase HRD68_08895 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HRD68_08910 ENOG4105C0P Mg chelatase subunit ChlI HRD68_08915 ENOG4108WFC UPF0438 protein yifE HRD68_08920 ENOG4105CVI Transcriptional regulator HRD68_08925 ENOG41062B0 ABC transporter, permease HRD68_08930 ENOG4107R9N ABC transporter HRD68_08935 ENOG4105C2J ABC transporter HRD68_08940 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HRD68_08980 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HRD68_08990 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HRD68_08995 ENOG4108Y73 Membrane HRD68_09005 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HRD68_09010 ENOG4105C5Q Transcriptional regulator HRD68_09015 ENOG4105EHV domain protein HRD68_09020 ENOG4107QN2 dihydrolipoyl dehydrogenase HRD68_09030 ENOG4107QZV Type I secretion membrane fusion protein HRD68_09045 ENOG4105X58 receptor HRD68_09050 ENOG4105CH7 arginosuccinase HRD68_09070 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HRD68_09075 ENOG4105DP0 ferredoxin-NADP reductase HRD68_09080 ENOG4105E5M Multidrug resistance protein D HRD68_09085 ENOG4105CBT Fructose-1,6-bisphosphatase HRD68_09090 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HRD68_09095 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HRD68_09100 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HRD68_09105 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HRD68_09110 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HRD68_09115 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HRD68_09120 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HRD68_09125 ENOG41063M6 Cell Division Protein HRD68_09130 ENOG4105ETE Transcriptional regulator (LacI family HRD68_09135 ENOG4105C25 Primosomal protein n' HRD68_09140 ENOG4105VFB Binds the 23S rRNA (By similarity) HRD68_09145 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HRD68_09150 ENOG4105C28 cystathionine HRD68_09155 ENOG4105CFH Aspartokinase HRD68_09160 ENOG4105SYT Methylenetetrahydrofolate reductase HRD68_09165 ENOG4108VTS Membrane HRD68_09170 ENOG4105EBK exported protein HRD68_09185 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HRD68_09195 ENOG41076HS cation diffusion facilitator family transporter HRD68_09200 ENOG4105FMW periplasmic HRD68_09205 ENOG4105E3W Two component transcriptional regulator (Winged helix family HRD68_09210 ENOG4105E0F Histidine kinase HRD68_09215 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HRD68_09220 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HRD68_09225 ENOG4105D7W serine acetyltransferase HRD68_09230 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HRD68_09235 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HRD68_09240 ENOG4105VW4 glutaredoxin 3 HRD68_09245 ENOG4107YZP Rhodanese domain protein HRD68_09250 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HRD68_09255 ENOG41063SB peptidase HRD68_09260 ENOG4105PXI polysaccharide deacetylase HRD68_09270 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HRD68_09275 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HRD68_09280 ENOG4105XA0 heptosyltransferase ii HRD68_09285 ENOG4105D16 lipopolysaccharide heptosyltransferase i HRD68_09290 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HRD68_09305 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HRD68_09310 ENOG4105W0E 50S ribosomal protein L33 HRD68_09315 ENOG4105KDC 50s ribosomal protein l28 HRD68_09325 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HRD68_09330 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HRD68_09335 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HRD68_09345 ENOG4108PU9 oligogalacturonate-specific porin HRD68_09355 ENOG4105BZU Histidine kinase HRD68_09360 ENOG4108JQ7 (ABC) transporter HRD68_09365 ENOG4105C3U ABC transporter HRD68_09370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRD68_09375 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRD68_09380 ENOG4105DEF Extracellular solute-binding protein, family 5 HRD68_09390 ENOG4105D5K Hemolysin activator protein HRD68_09400 ENOG4105CXY transporter HRD68_09405 ENOG4105BZU Histidine kinase HRD68_09410 ENOG4108KX4 response regulator HRD68_09415 ENOG4105DIJ Phosphoethanolamine transferase HRD68_09420 ENOG4108ZHJ Organic hydroperoxide resistance protein HRD68_09430 ENOG4105C85 amino acid HRD68_09435 ENOG4105C84 Histidine ammonia-lyase HRD68_09440 ENOG4105CGP Urocanate hydratase HRD68_09445 ENOG4105BZU Histidine kinase HRD68_09450 ENOG4105E39 Enoyl-CoA hydratase HRD68_09455 ENOG4105D9N nucleoside HRD68_09465 ENOG4105EN6 Membrane HRD68_09470 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HRD68_09480 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HRD68_09485 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HRD68_09490 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HRD68_09495 ENOG4105CB5 ATP-dependent DNA helicase recG HRD68_09500 ENOG4105D6U Sodium Glutamate Symporter HRD68_09505 ENOG4105C2W permease HRD68_09510 ENOG4105JV1 AsmA family HRD68_09530 ENOG4105SUU thioesterase domain HRD68_09540 ENOG4107S2Z UPF0761 membrane protein HRD68_09545 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HRD68_09550 ENOG4105CI3 gtp-binding protein typa HRD68_09555 ENOG4105C5F glutamine synthetase HRD68_09560 ENOG4105CUX Signal transduction histidine kinase HRD68_09565 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HRD68_09570 ENOG4105D4P Coproporphyrinogen iii oxidase HRD68_09575 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HRD68_09580 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HRD68_09585 ENOG4105C2M dna polymerase I HRD68_09590 ENOG4108Z33 Thiol disulfide Interchange Protein HRD68_09595 ENOG4105E27 serine threonine protein kinase HRD68_09600 ENOG4105PC1 Conserved Protein HRD68_09610 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HRD68_09635 ENOG4107EJG GntR family transcriptional regulator HRD68_09640 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRD68_09645 ENOG4105ETE Transcriptional regulator (LacI family HRD68_09650 ENOG4108RVA ribokinase HRD68_09655 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HRD68_09660 ENOG4105CNN ABC, transporter HRD68_09670 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HRD68_09680 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) HRD68_09685 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HRD68_09695 ENOG4105CU9 asparagine synthetase A HRD68_09700 ENOG4108VVK transcriptional Regulator, AsnC HRD68_09705 ENOG4105QTB Flavodoxin HRD68_09710 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HRD68_09715 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HRD68_09720 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HRD68_09725 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HRD68_09730 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HRD68_09735 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HRD68_09740 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HRD68_09745 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HRD68_09750 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HRD68_09755 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HRD68_09760 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HRD68_09765 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HRD68_09775 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HRD68_09780 ENOG4105C8U phosphate abc transporter HRD68_09785 ENOG4105E2Z phosphate ABC transporter (Permease HRD68_09800 ENOG4106PMH Extracellular solute-binding protein family 3 HRD68_09805 ENOG4105EAD ABC transporter HRD68_09810 ENOG4105DRP amino acid AbC transporter HRD68_09815 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HRD68_09820 ENOG4105C7N Xanthine uracil vitamin C permease HRD68_09835 ENOG4105BZU Histidine kinase HRD68_09840 ENOG4108YYH Nadph-dependent fmn reductase HRD68_09845 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_09850 ENOG4108UMI ABC transporter, permease HRD68_09855 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HRD68_09885 ENOG4105RKW reductase (By HRD68_09890 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HRD68_09895 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HRD68_09905 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HRD68_09915 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HRD68_09920 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HRD68_09930 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRD68_09935 ENOG410667J hydrolase HRD68_09950 ENOG4108SGR YheO domain-containing protein HRD68_09955 ENOG4105D99 atp gtp-binding protein HRD68_09960 ENOG4105R2A (LipO)protein HRD68_09975 ENOG4105D0C transport protein HRD68_09980 ENOG4105JKW Valine--pyruvate aminotransferase HRD68_09985 ENOG4107T9C Alpha amylase catalytic region HRD68_10005 ENOG4108ZG0 Ompa motb domain protein HRD68_10020 ENOG4108R3E Dna-3-methyladenine glycosylase i HRD68_10030 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HRD68_10035 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HRD68_10040 ENOG4106JH6 (LipO)protein HRD68_10050 ENOG4105EM7 Selenocysteine-specific translation elongation factor HRD68_10055 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HRD68_10060 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HRD68_10065 ENOG4108MG3 formate dehydrogenase HRD68_10070 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HRD68_10080 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HRD68_10085 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HRD68_10090 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_10095 ENOG4108RPX mosc domain containing protein HRD68_10105 ENOG4108YYI Protein of unknown function (DUF2810) HRD68_10110 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HRD68_10120 ENOG4105E61 Mannitol repressor protein HRD68_10125 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HRD68_10130 ENOG4105CTS PTS system mannitol-specific HRD68_10135 ENOG4105MEV Acyl-transferase HRD68_10140 ENOG4105ECQ AraC Family Transcriptional Regulator HRD68_10145 ENOG4108RWI nicotinamidase HRD68_10160 ENOG4108TTM chaperone HRD68_10170 ENOG4105CMG Carbohydrate kinase HRD68_10175 ENOG4105C93 Xylose Isomerase HRD68_10180 ENOG4105DFW ABC transporter HRD68_10190 ENOG4108HWW ABC transporter HRD68_10195 ENOG4105T16 Transcriptional regulator (AraC family) HRD68_10205 ENOG4105DFP Integrase HRD68_10215 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HRD68_10235 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HRD68_10285 ENOG4106H6R UPF0380 protein HRD68_10290 ENOG4108XS9 dna repair protein HRD68_10295 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HRD68_10300 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HRD68_10310 ENOG4105CKT filamentous hemagglutinin HRD68_10315 ENOG4105D5K Hemolysin activator protein HRD68_10335 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HRD68_10355 ENOG4105DSJ YicC domain protein HRD68_10360 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HRD68_10365 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HRD68_10370 ENOG4105CK2 sodium dicarboxylate symporter HRD68_10375 ENOG4105CS0 peptidase HRD68_10380 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HRD68_10385 ENOG4105VSH 4-oxalocrotonate tautomerase HRD68_10390 ENOG4105CMB EAL domain-containing protein HRD68_10395 ENOG41066T0 asmA family HRD68_10400 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HRD68_10405 ENOG4107H3J ribonuclease HRD68_10410 ENOG4105DC8 reductase HRD68_10415 ENOG4105D6S protein involved in catabolism of external DNA HRD68_10425 ENOG4105DGW oligopeptidase A HRD68_10430 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HRD68_10445 ENOG4108M6U Universal stress protein A HRD68_10450 ENOG4108V6B universal stress protein B HRD68_10455 ENOG4105CJ3 phosphate transporter HRD68_10460 ENOG4105CBX hi0933 family HRD68_10465 ENOG4108Q9V regulatoR HRD68_10470 ENOG4107ZHV Transcriptional regulator HRD68_10480 ENOG4105CR8 Transcriptional regulator HRD68_10485 ENOG4105EQ0 Major Facilitator superfamily HRD68_10500 ENOG4105C26 Dehydrogenase HRD68_10505 ENOG4105DH8 myo-inositol catabolism HRD68_10525 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HRD68_10530 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HRD68_10535 ENOG4105WCN acetyltransferase HRD68_10540 ENOG4105C2I pirin domain protein HRD68_10545 ENOG4105DIQ Transcriptional regulator HRD68_10550 ENOG4105C6Z Gluconate HRD68_10555 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HRD68_10560 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HRD68_10565 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HRD68_10570 ENOG4108HRK Histidine kinase HRD68_10575 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HRD68_10580 ENOG4108IUM Glycogen debranching enzyme HRD68_10590 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HRD68_10595 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HRD68_10600 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HRD68_10605 ENOG4105E98 transcriptional regulator DeoR family HRD68_10610 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HRD68_10625 ENOG41061ZR Transcriptional regulator HRD68_10630 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HRD68_10635 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HRD68_10640 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HRD68_10645 ENOG4105MJ2 Competence protein HRD68_10650 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HRD68_10655 ENOG4105RID UPF0379 protein yhcN HRD68_10660 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HRD68_10665 ENOG4105CE1 Ferrous iron transport protein b HRD68_10670 ENOG4105XFK Ferrous iron transport protein A HRD68_10675 ENOG4105BZM domain protein HRD68_10680 ENOG4108RRZ Transcription elongation factor GreB HRD68_10690 ENOG4105E0F Histidine kinase HRD68_10705 ENOG4108S1B Periplasmic chaperone protein HRD68_10710 ENOG4108D1K outer membrane usher protein HRD68_10730 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HRD68_10740 ENOG4105VEJ Heat shock protein HRD68_10745 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HRD68_10750 ENOG4105DQY intracellular growth attenuator HRD68_10755 ENOG4107RK2 ADP-ribose diphosphatase NudE HRD68_10760 ENOG4108JQC penicillin-binding protein 1A HRD68_10785 ENOG4105E4G Type IV pilus HRD68_10790 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HRD68_10810 ENOG4105DJV ribulose-phosphate 3-epimerase HRD68_10820 ENOG4105C31 Tryptophanyl-tRNA synthetase HRD68_10825 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HRD68_10830 ENOG4107V9H nitrite transporter HRD68_10835 ENOG4105WZK nitrite reductase NADPH small subunit HRD68_10840 ENOG4107QZF nitrite reductase NADPH large subunit HRD68_10845 ENOG4105DZC cytosine deaminase HRD68_10850 ENOG4106DTQ Protein TsgA homolog HRD68_10860 ENOG4107RNH Outer membrane receptor FepA HRD68_10865 ENOG41060NJ transcriptional regulator HRD68_10870 ENOG4105F8D glycoside hydrolase family 4 HRD68_10875 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HRD68_10880 ENOG4105D7A ATP-binding protein HRD68_10890 ENOG4105C8Y Acetylornithine aminotransferase HRD68_10925 ENOG4105TNG K13735 adhesin invasin HRD68_10940 ENOG410613R integral membrane protein, YccS YhfK family HRD68_10945 ENOG4107RYR Transcriptional regulator, Crp Fnr family HRD68_10950 ENOG4108UKZ OsmC family HRD68_10955 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HRD68_10960 ENOG4105YP7 UPF0270 protein HRD68_10965 ENOG4105DNZ Alpha Beta Hydrolase HRD68_10975 ENOG4105JAB phenazine biosynthesis protein, phzf family HRD68_10980 ENOG4106FTQ Taurine ABC transporter, periplasmic HRD68_10990 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HRD68_10995 ENOG4105E2B Taurine dioxygenase HRD68_11005 ENOG4105C5H ABC transporter HRD68_11010 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HRD68_11020 ENOG4105VKU nucleicacid-binding protein HRD68_11025 ENOG4108YZY peptidylprolyl cis-trans isomerase HRD68_11035 ENOG4108V1T peptidylprolyl cis-trans isomerase HRD68_11040 ENOG4105WWK YheO domain protein HRD68_11045 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HRD68_11055 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HRD68_11065 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HRD68_11075 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HRD68_11095 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HRD68_11100 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HRD68_11105 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HRD68_11115 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HRD68_11120 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HRD68_11125 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HRD68_11130 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HRD68_11135 ENOG41083MP 50s ribosomal protein l29 HRD68_11140 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HRD68_11160 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HRD68_11170 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HRD68_11175 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HRD68_11180 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HRD68_11185 ENOG4105VPB 50S ribosomal protein L30 HRD68_11190 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HRD68_11195 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HRD68_11205 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HRD68_11210 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HRD68_11215 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HRD68_11220 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HRD68_11225 ENOG4108ZT0 50S ribosomal protein l17 HRD68_11230 ENOG4105VTS DnaJ-like, subfamily C HRD68_11235 ENOG4105W1Y Transcriptional regulator HRD68_11240 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HRD68_11245 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HRD68_11250 ENOG4105C1A potassium transporter peripheral membrane HRD68_11255 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HRD68_11260 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HRD68_11265 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HRD68_11270 ENOG4105C79 DNA protecting protein DprA HRD68_11280 ENOG4108WI1 Dna topoisomerase HRD68_11285 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HRD68_11290 ENOG4105E2X shikimate dehydrogenase HRD68_11295 ENOG4108Z0R Transferase HRD68_11325 ENOG4105CVG Homoserine O-transsuccinylase HRD68_11330 ENOG4107QP3 malate synthase g HRD68_11335 ENOG4108I9X Isocitrate lyase HRD68_11340 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HRD68_11345 ENOG41069M3 Transcriptional regulator HRD68_11350 ENOG4105C3R Methionine synthase HRD68_11355 ENOG4105C09 Bile acid HRD68_11360 ENOG4105CFH Aspartokinase HRD68_11375 ENOG4105EG2 ABC transporter, permease HRD68_11380 ENOG4105D56 permease protein HRD68_11385 ENOG4107FKK extracellular solute-binding protein family 1 HRD68_11395 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HRD68_11400 ENOG4107W52 maltose operon periplasmic protein HRD68_11405 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HRD68_11415 ENOG4105E55 glycerol-3-phosphate acyltransferase HRD68_11420 ENOG41080IJ Diacylglycerol kinase HRD68_11425 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HRD68_11430 ENOG4105VDW Csbd family HRD68_11435 ENOG4105MYN Zinc uptake regulation protein HRD68_11445 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HRD68_11450 ENOG4105P4Z Phage shock protein G HRD68_11455 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HRD68_11460 ENOG4105CDU Replicative dna helicase HRD68_11470 ENOG4105CGF Aromatic amino acid aminotransferase HRD68_11475 ENOG4105MSB protein, conserved in bacteria HRD68_11480 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HRD68_11485 ENOG4108UUM single-stranded DNA-binding protein HRD68_11505 ENOG4105C7N Xanthine uracil vitamin C permease HRD68_11510 ENOG4105EEQ Na H antiporter HRD68_11515 ENOG4105CMU LysR family (Transcriptional regulator HRD68_11525 ENOG41067MG lrgb family HRD68_11530 ENOG4105CDA abc transporter atp-binding protein HRD68_11535 ENOG4105DRP amino acid AbC transporter HRD68_11540 ENOG4105EZ7 amino acid ABC transporter HRD68_11555 ENOG4105D1S lipid A biosynthesis HRD68_11565 ENOG4105C2J ABC transporter HRD68_11570 ENOG4105CNN ABC, transporter HRD68_11580 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HRD68_11585 ENOG4105C2X Arabinose 5-phosphate isomerase HRD68_11590 ENOG4107QPK )-transporter HRD68_11595 ENOG4105VEQ Cold shock protein HRD68_11600 ENOG4105VEQ Cold shock protein HRD68_11605 ENOG4108XTF Outer Membrane Lipoprotein HRD68_11620 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HRD68_11625 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HRD68_11630 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HRD68_11635 ENOG4108IA2 Sodium pantothenate symporter HRD68_11640 ENOG4105RG0 Membrane HRD68_11645 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HRD68_11650 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HRD68_11660 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HRD68_11670 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HRD68_11675 ENOG41062P1 Diguanylate cyclase phosphodiesterase HRD68_11685 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HRD68_11690 ENOG4105VQ7 Rod shape-determining protein MreD HRD68_11695 ENOG4108Z03 MAF-like protein HRD68_11700 ENOG4105C03 ribonuclease HRD68_11705 ENOG4105QD6 exported protein HRD68_11715 ENOG4105D1U peptidase U62 modulator of DNA gyrase HRD68_11720 ENOG4105CR8 Transcriptional regulator HRD68_11725 ENOG4105ZQC membrane protein AaeX HRD68_11730 ENOG4105Y49 secretion protein, HlyD family HRD68_11735 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HRD68_11750 ENOG4105UNR (Barnase) inhibitor HRD68_11755 ENOG4105N42 UPF0307 protein HRD68_11760 ENOG4105CMS peptidase U62, modulator of DNA gyrase HRD68_11770 ENOG4108XVM Cytochrome b(562) HRD68_11775 ENOG4105NXH GreA GreB family elongation factor HRD68_11805 ENOG41069H0 dihydroorotase EC 3.5.2.3 HRD68_11820 ENOG4105EMD TRANSCRIPTIONal HRD68_11830 ENOG4105D4X repressor HRD68_11835 ENOG4105C5Y PTS System HRD68_11840 ENOG4105CG3 alpha amylase, catalytic region HRD68_11845 ENOG4105I03 Flagellin HRD68_11875 ENOG4105KME endoribonuclease L-psp HRD68_11880 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HRD68_11885 ENOG4105CXT aspartate transcarbamylase HRD68_11890 ENOG41080Z8 PHOSPHOCARRIER protein HRD68_11900 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HRD68_11905 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HRD68_11910 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRD68_11915 ENOG4108IUZ ABC transporter HRD68_11920 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HRD68_11925 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HRD68_11930 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HRD68_11935 ENOG4105C2X Arabinose 5-phosphate isomerase HRD68_11940 ENOG4105FEU K -dependent Na -Ca exchanger HRD68_11945 ENOG4105DHJ ABC, transporter HRD68_11950 ENOG4105CY3 ABC transporter, permease HRD68_11955 ENOG4107PE3 Mammalian cell entry related domain protein HRD68_11960 ENOG4105E3I toluene tolerance HRD68_11965 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HRD68_11970 ENOG4105VFK BolA family HRD68_11975 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HRD68_11980 ENOG4105C0H protease HRD68_11985 ENOG4105C0H protease HRD68_11990 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HRD68_12000 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HRD68_12005 ENOG4108UJD 30S ribosomal protein S9 HRD68_12010 ENOG4107MKT Stringent starvation protein a HRD68_12015 ENOG4105KB2 stringent starvation protein b HRD68_12025 ENOG4105BZ8 glutamate synthase HRD68_12030 ENOG4105CBC glutamate synthase HRD68_12035 ENOG4105N5T Radical SAM Protein HRD68_12040 ENOG4105BZU Histidine kinase HRD68_12045 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HRD68_12050 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HRD68_12055 ENOG4105W4M Transport-associated protein HRD68_12060 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HRD68_12065 ENOG41082RQ UPF0102 protein HRD68_12075 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HRD68_12100 ENOG4105EQ2 LysR family Transcriptional regulator HRD68_12110 ENOG4105DQ4 alcohol dehydrogenase HRD68_12115 ENOG4108CNN domain protein HRD68_12120 ENOG4105CWB LysR family transcriptional Regulator HRD68_12125 ENOG4105CHF Glutathione S-transferase HRD68_12130 ENOG4108VBZ doxx family HRD68_12135 ENOG4105YJD HRD68_12140 ENOG41090KG Inner membrane protein YqjE HRD68_12145 ENOG4105NE1 Conserved Protein HRD68_12160 ENOG4106W5V Membrane HRD68_12175 ENOG4105DPW Major facilitator superfamily MFS_1 HRD68_12180 ENOG4105D2H Uronic isomerase HRD68_12185 ENOG4107QZW Altronate oxidoreductase HRD68_12190 ENOG4105CTX dehydratase HRD68_12195 ENOG4105P66 Membrane HRD68_12200 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HRD68_12205 ENOG4105DU1 integral membrane protein, terc HRD68_12215 ENOG4105EE0 oxidoreductase HRD68_12220 ENOG4108VKG metal-dependent hydrolase HRD68_12225 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HRD68_12235 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HRD68_12240 ENOG4108YK4 Acid-resistance membrane protein HRD68_12250 ENOG4108UHU Aldolase HRD68_12255 ENOG4108I5G Major Facilitator superfamily HRD68_12270 ENOG4105C0A alcohol dehydrogenase HRD68_12275 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HRD68_12290 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HRD68_12350 ENOG4105ED4 portal protein HRD68_12425 ENOG4105M03 Domain of unknown function (DUF955) HRD68_12500 ENOG4105ZTC transcriptional activator, Ogr delta HRD68_12510 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRD68_12515 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HRD68_12525 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HRD68_12530 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HRD68_12535 ENOG4107ZVW dihydroneopterin aldolase HRD68_12540 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HRD68_12545 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HRD68_12550 ENOG4106MWK domain protein HRD68_12555 ENOG4105I7R Adenylate cyclase HRD68_12560 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HRD68_12565 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HRD68_12570 ENOG4105DVH amino acid HRD68_12575 ENOG4105W0Z cytoplasmic protein HRD68_12580 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HRD68_12585 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HRD68_12590 ENOG4106032 Glutathionylspermidine synthase HRD68_12595 ENOG4105F1G UPF0441 protein HRD68_12600 ENOG4105DFG type I secretion outer membrane protein HRD68_12605 ENOG41087AY ADP-Ribose pyrophosphatase HRD68_12610 ENOG4108SX3 cytoplasmic protein HRD68_12615 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HRD68_12620 ENOG4105IPS esterase HRD68_12625 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRD68_12630 ENOG4105JQN Transcriptional regulator HRD68_12635 ENOG4105VRH Antibiotic biosynthesis monooxygenase HRD68_12640 ENOG4105NF4 modulator of drug activity HRD68_12645 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HRD68_12650 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HRD68_12655 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HRD68_12665 ENOG4105CV8 reductase HRD68_12670 ENOG4108I6A alcohol dehydrogenase HRD68_12675 ENOG4105CF7 AraC family transcriptional regulator HRD68_12680 ENOG4108K81 inner membrane protein YghB HRD68_12685 ENOG4105C28 cystathionine HRD68_12690 ENOG4105CWK Biopolymer transport protein, ExbB HRD68_12695 ENOG4108ZZF transport protein (ExbD) HRD68_12770 ENOG4108IJF Heavy metal efflux pump, CzcA HRD68_12775 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HRD68_12800 ENOG4105E0A ABC, transporter HRD68_12805 ENOG4105TVJ transport system, permease HRD68_12810 ENOG4105DQ5 transport system permease protein HRD68_12830 ENOG4105ETE Transcriptional regulator (LacI family HRD68_12840 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HRD68_12845 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_12860 ENOG4108M3R transcriptional activator CadC HRD68_12865 ENOG4108XTF Outer Membrane Lipoprotein HRD68_12870 ENOG4105E3S small subunit HRD68_12875 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HRD68_12880 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HRD68_12885 ENOG4105DPX Hydrogenase, large subunit HRD68_12890 ENOG4108USZ hydrogenase HRD68_12895 ENOG4108WGS hydrogenase 2-specific chaperone HRD68_12900 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HRD68_12905 ENOG4107RSS Hydrogenase accessory protein HypB HRD68_12910 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HRD68_12915 ENOG4105CQS hydrogenase expression formation protein HypD HRD68_12920 ENOG4105C45 hydrogenase expression formation protein (HypE) HRD68_12925 ENOG4105C8H hydrogenase maturation protein Hypf HRD68_12930 ENOG4108KKZ (LipO)protein HRD68_12940 ENOG4107QPK )-transporter HRD68_12945 ENOG4107GFK fumarate HRD68_12950 ENOG4106DSS Tartrate dehydratase subunit alpha HRD68_12955 ENOG4105EJC lysr family transcriptional regulator HRD68_12960 ENOG4105C1P efflux transporter, rnd family, mfp subunit HRD68_12970 ENOG4105C85 amino acid HRD68_12975 ENOG4105CPD ethanolamine ammonia-lyase HRD68_12980 ENOG4107FQ9 ethanolamine ammonia-lyase HRD68_12985 ENOG4105CSH Transporter HRD68_13000 ENOG4105EAM Na Pi-cotransporter HRD68_13010 ENOG4105ETE Transcriptional regulator (LacI family HRD68_13030 ENOG4105CM4 permease protein HRD68_13035 ENOG4108IPW abc transporter atp-binding protein HRD68_13040 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HRD68_13055 ENOG4105D2N Aldolase HRD68_13060 ENOG4105E70 isomerase HRD68_13065 ENOG4105CE4 GlcNAc 6-P deacetylase HRD68_13070 ENOG4108YTN IIa component HRD68_13075 ENOG4105F3R pts system mannose fructose sorbose family iid HRD68_13085 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HRD68_13090 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HRD68_13095 ENOG4105E98 transcriptional regulator DeoR family HRD68_13100 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HRD68_13105 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HRD68_13110 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRD68_13115 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRD68_13120 ENOG4108RZA ABC transporter HRD68_13125 ENOG4108S9F abc transporter, atp-binding protein HRD68_13130 ENOG4105D5K Hemolysin activator protein HRD68_13135 ENOG4105CKT filamentous hemagglutinin HRD68_13215 ENOG4108ZG0 Ompa motb domain protein HRD68_13225 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HRD68_13305 ENOG4105CI2 imidazolone-5-propionate hydrolase HRD68_13315 ENOG4105J12 Multidrug resistance protein mdtN HRD68_13320 ENOG4108MI0 Resistance protein HRD68_13440 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HRD68_13460 ENOG4105TNG K13735 adhesin invasin HRD68_13480 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_13485 ENOG4108WQH regulatoR HRD68_13510 ENOG4105M9M anti-sigma28 factor FlgM HRD68_13520 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HRD68_13525 ENOG4108ZC9 flagellar basal-body rod protein flgc HRD68_13530 ENOG4105W00 Flagellar hook capping protein HRD68_13535 ENOG4105BZE flagellar hook protein, FlgE HRD68_13540 ENOG4108KPB Flagellar basal-body rod protein FlgF HRD68_13545 ENOG4105CGA flagellar basal-body rod protein FlgG HRD68_13560 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HRD68_13565 ENOG4105E1Q flagellar hook-associated protein HRD68_13570 ENOG4105DTJ flagellar hook-associated protein HRD68_13575 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRD68_13580 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HRD68_13585 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HRD68_13590 ENOG4107RD7 Flagellar Motor Protein, MotA HRD68_13595 ENOG4105ER2 Ompa motb domain protein HRD68_13600 ENOG4105CBS Chea signal transduction histidine kinase HRD68_13605 ENOG4108V3W Chemotaxis protein, CheW HRD68_13615 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_13620 ENOG4105I03 Flagellin HRD68_13625 ENOG4105DTS flagellar hook-associated HRD68_13630 ENOG4105MQ3 flagellar protein FliS HRD68_13645 ENOG4105D7B Flagellar biosynthesis protein flha HRD68_13650 ENOG4105D00 flagellar biosynthetic protein flhB HRD68_13655 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HRD68_13660 ENOG4108VYJ response regulator receiver protein HRD68_13665 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HRD68_13670 ENOG4105BZU Histidine kinase HRD68_13675 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HRD68_13680 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HRD68_13685 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HRD68_13690 ENOG4108CG0 Flagellar assembly protein HRD68_13695 ENOG4108JIR Flagellum-specific ATP synthase HRD68_13705 ENOG4105WF4 Flagellar hook-length control protein HRD68_13710 ENOG4107ZI8 flagellar basal body-associated protein flil HRD68_13715 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HRD68_13720 ENOG4105DD5 Flagellar motor switch protein HRD68_13730 ENOG4105CN7 Flagellar biosynthetic protein FliP HRD68_13740 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HRD68_13750 ENOG4105CJZ response regulator HRD68_13755 ENOG41066YJ Beta-lactamase HRD68_13765 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HRD68_13775 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HRD68_13780 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) HRD68_13790 ENOG4105DDC Oxidoreductase domain protein HRD68_13795 ENOG4105CAZ oligogalacturonide lyase HRD68_13800 ENOG410769Z extracellular solute-binding protein family 1 HRD68_13805 ENOG4107TRE AP endonuclease, family 2 HRD68_13810 ENOG4105C28 cystathionine HRD68_13815 ENOG4105C44 Serine transporter HRD68_13820 ENOG4105CR8 Transcriptional regulator HRD68_13830 ENOG4105VMP Transcriptional regulator HRD68_13845 ENOG4105GQR Chaperone HRD68_13850 ENOG4105CW0 outer membrane usher protein HRD68_13875 ENOG4105CXN decarboxylase HRD68_13880 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HRD68_13890 ENOG4105CEN a g-specific adenine glycosylase HRD68_13895 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HRD68_13900 ENOG41090ED Protein with unknown function (DUF469) HRD68_13910 ENOG4105K33 Periplasmic Protein HRD68_13915 ENOG4105CSA Coproporphyrinogen iii oxidase HRD68_13925 ENOG4105VZ9 UPF0235 protein HRD68_13930 ENOG4108VIA integral membrane protein HRD68_13935 ENOG4105II7 pyrroline-5-carboxylate reductase HRD68_13940 ENOG4105DFA alanine racemase domain protein HRD68_13945 ENOG4105CZX twitching motility protein HRD68_13955 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) HRD68_13960 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HRD68_13965 ENOG4108UJU UPF0301 protein HRD68_13970 ENOG4105D7Z glutathione synthase HRD68_13975 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HRD68_13980 ENOG4105RWS endonuclease I HRD68_13985 ENOG4105GPY SprT protein HRD68_13990 ENOG41080HT Transcriptional regulator, arsr family HRD68_14005 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HRD68_14010 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HRD68_14020 ENOG4108K0D peptidase, M48 HRD68_14025 ENOG4105CV1 Transketolase (EC 2.2.1.1) HRD68_14030 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HRD68_14035 ENOG4105BZA Phosphoglycerate kinase HRD68_14040 ENOG4105D2N Aldolase HRD68_14050 ENOG4105D64 Mechanosensitive ion channel HRD68_14055 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HRD68_14060 ENOG4105MPN Membrane HRD68_14065 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HRD68_14070 ENOG4105E66 phosphoriboisomerase A HRD68_14075 ENOG4108JQ1 Dehydrogenase HRD68_14080 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HRD68_14090 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HRD68_14095 ENOG4105E07 UPF0149 protein HRD68_14100 ENOG4107RAQ aminopeptidase HRD68_14105 ENOG4105D0A hydroxylase HRD68_14110 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HRD68_14115 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HRD68_14120 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HRD68_14125 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HRD68_14130 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HRD68_14135 ENOG4108UT2 hemolysin iii HRD68_14140 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HRD68_14155 ENOG4105E3W Two component transcriptional regulator (Winged helix family HRD68_14160 ENOG4105EB3 Histidine kinase HRD68_14165 ENOG4105CT7 inner membrane cred family protein HRD68_14170 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HRD68_14175 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HRD68_14180 ENOG4105T95 Thiol disulfide interChange protein HRD68_14185 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HRD68_14230 ENOG4105BZU Histidine kinase HRD68_14235 ENOG4105F7P transcriptional regulator AsnC family HRD68_14250 ENOG4105DPW Major facilitator superfamily MFS_1 HRD68_14260 ENOG4105DVC DnaJ domain protein HRD68_14270 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HRD68_14275 ENOG4105KVH Transcriptional regulator HRD68_14310 ENOG4105EJC lysr family transcriptional regulator HRD68_14315 ENOG4105F27 Major Facilitator HRD68_14320 ENOG4105RQF LysR family Transcriptional regulator HRD68_14330 ENOG41060NJ transcriptional regulator HRD68_14340 ENOG4105CEY Amp-dependent synthetase and ligase HRD68_14345 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) HRD68_14350 ENOG4108Z3N Transcriptional regulator HRD68_14355 ENOG4105CPC Aldo Keto reductase HRD68_14360 ENOG4105EE5 Membrane protein terC HRD68_14365 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HRD68_14370 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HRD68_14375 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HRD68_14380 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HRD68_14410 ENOG4105DSY exodeoxyribonuclease V, gamma HRD68_14415 ENOG4107QXK peptidase HRD68_14420 ENOG4107QKA exodeoxyribonuclease V beta HRD68_14425 ENOG4107QYX exodeoxyribonuclease v alpha HRD68_14430 ENOG4107QZM n-acetylglutamate synthase HRD68_14435 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HRD68_14455 ENOG4105CA3 membrane-bound lytic murein transglycosylase HRD68_14460 ENOG4105CUZ uba thif-type nad fad binding protein HRD68_14465 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HRD68_14470 ENOG4105C9B Cysteine desulfurase HRD68_14475 ENOG4105M5B (LipO)protein HRD68_14480 ENOG4105ETT transcriptional Regulator, LysR family HRD68_14485 ENOG4105M08 Membrane HRD68_14490 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HRD68_14500 ENOG4105EWT decarboxylase family HRD68_14505 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HRD68_14510 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HRD68_14515 ENOG4105WP7 tRNA pseudouridine synthase C HRD68_14520 ENOG4105DR9 pseudouridine synthase HRD68_14525 ENOG4105QDK Flavodoxin HRD68_14535 ENOG4108T8E UPF0325 protein HRD68_14540 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HRD68_14545 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HRD68_14550 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HRD68_14560 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HRD68_14565 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HRD68_14575 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HRD68_14585 ENOG4105KNE Phosphatidate cytidylyltransferase HRD68_14590 ENOG4105DZP Membrane-associated zinc metalloprotease HRD68_14600 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HRD68_14605 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HRD68_14615 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HRD68_14625 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HRD68_14630 ENOG4105C0B DNA polymerase III (alpha subunit) HRD68_14635 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HRD68_14640 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HRD68_14655 ENOG4105M1T rho-binding antiterminator HRD68_14665 ENOG4108VWS Yaeq family HRD68_14670 ENOG4108YZN class I peptide chain release factor HRD68_14675 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HRD68_14680 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HRD68_14685 ENOG4108R96 Methyltransferase, YaeB family HRD68_14690 ENOG4108R8X outer membrane lipoprotein HRD68_14695 ENOG4105D01 (LipO)protein HRD68_14700 ENOG4108UMI ABC transporter, permease HRD68_14710 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HRD68_14745 ENOG4105HEI LysR family (Transcriptional regulator HRD68_14750 ENOG4105CV8 reductase HRD68_14755 ENOG4107NA1 Endonuclease Exonuclease phosphatase HRD68_14760 ENOG4105E9H Lytic Murein transglycosylase HRD68_14765 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HRD68_14770 ENOG4105D1A Methyltransferase HRD68_14780 ENOG4107RZZ dna polymerase iii epsilon subunit HRD68_14790 ENOG4105GIJ Glycine betaine HRD68_14795 ENOG4108HQS Glycine betaine HRD68_14800 ENOG4108IJ7 Glycine betaine HRD68_14805 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HRD68_14815 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HRD68_14825 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HRD68_14835 ENOG4105NE1 Conserved Protein HRD68_14845 ENOG4108WMJ Protein of unknown function (DUF2002) HRD68_14850 ENOG4108SAJ Protein of unknown function (DUF1198) HRD68_14860 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HRD68_14865 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRD68_14870 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRD68_14875 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HRD68_14880 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HRD68_14890 ENOG4108YZ9 Urea amidohydrolase subunit gamma HRD68_14895 ENOG4105KI2 Urea amidohydrolase subunit beta HRD68_14900 ENOG4105CQM Urea amidohydrolase subunit alpha HRD68_14905 ENOG4108VDS Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HRD68_14915 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HRD68_14935 ENOG4105XXV Acid-resistance protein HRD68_14940 ENOG4107SVH Potassium channel protein HRD68_14955 ENOG4105D8V Glucose sorbosone dehydrogenase HRD68_14960 ENOG4105VZJ PTS System HRD68_14965 ENOG4105CK1 PTS System HRD68_14970 ENOG4105VCP PTS System HRD68_14975 ENOG4105EZV Transcriptional regulator HRD68_14980 ENOG410901P UPF0249 protein HRD68_14990 ENOG4108SF5 RNA Polymerase HRD68_14995 ENOG4108S3W Anti-feci sigma factor, fecr HRD68_15000 ENOG4105GAV receptor HRD68_15005 ENOG4108HUF Transporter HRD68_15010 ENOG4105DQ5 transport system permease protein HRD68_15015 ENOG4108IHU transport system permease protein HRD68_15020 ENOG4105E0A ABC, transporter HRD68_15035 ENOG4105VUF Transcriptional regulator HRD68_15050 ENOG4105KME endoribonuclease L-psp HRD68_15055 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HRD68_15120 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HRD68_15125 ENOG4108Z1B Cyclase dehydrase HRD68_15135 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HRD68_15140 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HRD68_15145 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HRD68_15150 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HRD68_15155 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HRD68_15160 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HRD68_15165 ENOG4105C1J atp-dependent rna helicase HRD68_15170 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HRD68_15175 ENOG4108IYU L-aspartate oxidase HRD68_15190 ENOG4105VQK sigma E regulatory protein, MucB RseB HRD68_15195 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HRD68_15210 ENOG4105C3F Signal peptidase i HRD68_15225 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HRD68_15230 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HRD68_15235 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HRD68_15240 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HRD68_15245 ENOG4106G6Q Transcriptional regulator HRD68_15250 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HRD68_15255 ENOG4108Z6B deaminase HRD68_15260 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HRD68_15275 ENOG4107WP9 Histidine kinase HRD68_15280 ENOG4108SKK alpha helix protein HRD68_15285 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HRD68_15290 ENOG4105C4K Nad synthetase HRD68_15295 ENOG4108YZA Nitrogen regulatory protein pii HRD68_15300 ENOG4106M0N transport system permease protein HRD68_15305 ENOG4105MUZ Protein of unknown function DUF2620 HRD68_15310 ENOG41080QX K07048 phosphotriesterase-related protein HRD68_15315 ENOG4108626 Racemase HRD68_15320 ENOG4105RMW regulation of transcription, DNA-dependent HRD68_15325 ENOG4108M21 HRD68_15330 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HRD68_15340 ENOG4105D8G Major Facilitator superfamily HRD68_15345 ENOG4108MN2 Stationary phase inducible protein CsiE HRD68_15350 ENOG41065CD Exported protein HRD68_15355 ENOG4105D7X high-affinity nickel-transporter HRD68_15360 ENOG4105ECY inositol monophosphatase HRD68_15365 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HRD68_15370 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HRD68_15380 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HRD68_15390 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HRD68_15395 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HRD68_15400 ENOG4108ZIT Ferredoxin, 2FE-2S HRD68_15405 ENOG4105WVQ Fe-S assembly protein IscX HRD68_15415 ENOG4105YYA enhanced serine sensitivity protein SseB HRD68_15420 ENOG4108MGN ATP-binding component of a transport system HRD68_15425 ENOG4105DN3 alpha-2-macroglobulin domain protein HRD68_15430 ENOG4108JQB penicillin-binding protein 1C HRD68_15455 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HRD68_15470 ENOG4105N21 Membrane HRD68_15475 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HRD68_15480 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HRD68_15490 ENOG4105VPD cellular component movement HRD68_15495 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HRD68_15500 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HRD68_15505 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HRD68_15515 ENOG4108TC1 Transcriptional regulator HRD68_15540 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HRD68_15550 ENOG4108NAE Fimbrial chaperone protein HRD68_15555 ENOG4108AF8 Chaperone HRD68_15560 ENOG4105CW0 outer membrane usher protein HRD68_15570 ENOG4105DWF phosphomethylpyrimidine kinase HRD68_15580 ENOG4108ZGU inhibitor of vertebrate lysozyme HRD68_15590 ENOG410804X Transcriptional regulator HRD68_15595 ENOG4105J92 DNA-binding transcriptional activator GutM HRD68_15600 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HRD68_15605 ENOG4105VI0 Pts system, glucitol sorbitol-specific HRD68_15610 ENOG4105DZY Pts system, glucitol sorbitol-specific HRD68_15615 ENOG410787A Pts system, glucitol sorbitol-specific HRD68_15620 ENOG4107TE5 Lipid kinase HRD68_15625 ENOG4105CFP Peptidase U32 HRD68_15630 ENOG4105KWI UPF0339 protein HRD68_15635 ENOG4105E3W Two component transcriptional regulator (Winged helix family HRD68_15640 ENOG4105EB3 Histidine kinase HRD68_15645 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRD68_15650 ENOG4105BZS acriflavin resistance protein HRD68_15660 ENOG4105ENT Efflux transporter rnd family, mfp subunit HRD68_15670 ENOG4105CW0 outer membrane usher protein HRD68_15675 ENOG4108VCD Chaperone HRD68_15685 ENOG4105R8A Heat shock protein HRD68_15690 ENOG4105BZU Histidine kinase HRD68_15695 ENOG4105CJW magnesium transporter HRD68_15705 ENOG4105C9X ppx gppa phosphatase HRD68_15710 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HRD68_15715 ENOG4105C8U phosphate abc transporter HRD68_15720 ENOG4105E2Z phosphate ABC transporter (Permease HRD68_15730 ENOG4108MK9 spermidine N(1)-acetyltransferase HRD68_15735 ENOG4108V3E phosphoribosylglycinamide formyltransferase HRD68_15745 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HRD68_15750 ENOG4105C2W permease HRD68_15755 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HRD68_15760 ENOG4105K89 arsenate reductase HRD68_15765 ENOG4105ERG peptidase m48, ste24p HRD68_15770 ENOG4105C02 permease HRD68_15775 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HRD68_15780 ENOG4105RH4 Glycine cleavage system transcriptional repressor HRD68_15785 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HRD68_15790 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HRD68_15795 ENOG4105C8V SAICAR synthetase HRD68_15800 ENOG4105CGZ zinc metallopeptidase HRD68_15805 ENOG4108VMM UPF0756 membrane protein HRD68_15810 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HRD68_15815 ENOG4106KED esterase YpfH HRD68_15820 ENOG4105XYK UPF0370 protein HRD68_15830 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HRD68_15835 ENOG4105KUZ arsenate reductase HRD68_15840 ENOG4105DDW LysR family Transcriptional regulator HRD68_15845 ENOG4105PFC Transcriptional regulator HRD68_15860 ENOG4107Z33 ABC transporter, permease HRD68_15865 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRD68_15870 ENOG4105BZS acriflavin resistance protein HRD68_15880 ENOG4105WH1 Two component transcriptional regulator luxr family HRD68_15885 ENOG4108ZNS ferredoxin-type protein NapF HRD68_15890 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HRD68_15895 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HRD68_15900 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HRD68_15905 ENOG4105CUW cytochrome C-TYPE protein HRD68_15910 ENOG4107VIJ nudix hydrolase HRD68_15915 ENOG4105C6K Malic enzyme HRD68_15925 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HRD68_15930 ENOG4108R6G acetyltransferase HRD68_15935 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HRD68_15940 ENOG4105C2J ABC transporter HRD68_15945 ENOG4105CNN ABC, transporter HRD68_15950 ENOG4108NQD HRD68_15965 ENOG4105KHC sulfurtransferase HRD68_15970 ENOG4105CHR reductase HRD68_15975 ENOG4105H4F exported protein HRD68_15980 ENOG4105E7K (LipO)protein HRD68_15985 ENOG4105EZR dyp-type peroxidase family protein HRD68_16005 ENOG4108R66 Conserved Protein HRD68_16010 ENOG4105QEK Transcriptional regulator HRD68_16020 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HRD68_16025 ENOG4108I5D sulfate abc transporter HRD68_16030 ENOG4105ECW sulfate abc transporter HRD68_16040 ENOG4105C6T cysteine synthase HRD68_16045 ENOG4105ECX polysaccharide export HRD68_16050 ENOG4107V1M polysaccharide export protein HRD68_16055 ENOG4105E12 capsule polysaccharide HRD68_16060 ENOG41084CK capsule polysaccharide HRD68_16065 ENOG4105K64 Glycosyl transferase, family 2 HRD68_16085 ENOG41090SZ ABC-2 type transporter HRD68_16095 ENOG4105DJY efflux transporter, rnd family, mfp subunit HRD68_16100 ENOG4105E3W Two component transcriptional regulator (Winged helix family HRD68_16105 ENOG4105E0F Histidine kinase HRD68_16110 ENOG4105C5Y PTS System HRD68_16115 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HRD68_16125 ENOG4105C6T cysteine synthase HRD68_16130 ENOG4105EXN Sulfate transport protein CysZ HRD68_16140 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HRD68_16145 ENOG4105VRT cytoplasmic protein HRD68_16170 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HRD68_16205 ENOG4105D9N nucleoside HRD68_16215 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HRD68_16225 ENOG4105CPC Aldo Keto reductase HRD68_16230 ENOG4107RA9 decarboxylase HRD68_16235 ENOG4105C5Q Transcriptional regulator HRD68_16245 ENOG4105CHC glucokinase (EC 2.7.1.2) HRD68_16250 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HRD68_16260 ENOG4105FCD Major Facilitator HRD68_16265 ENOG4105DY9 regulatoR HRD68_16270 ENOG4108HRK Histidine kinase HRD68_16275 ENOG41072TH Protein of unknown function (DUF1479) HRD68_16285 ENOG4105CHM Aminotransferase HRD68_16290 ENOG4108VKM cytochrome b561 HRD68_16300 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HRD68_16320 ENOG4108TGR phosphatase HRD68_16325 ENOG4106B0W Curli production assembly transport component CsgG HRD68_16335 ENOG4107Y60 (LipO)protein HRD68_16350 ENOG4107KGK dmso reductase anchor subunit HRD68_16355 ENOG4105QAX Iron-sulfur HRD68_16360 ENOG4107QY8 reductase HRD68_16375 ENOG4105CVE Lytic murein transglycosylase HRD68_16380 ENOG4105CUB amino acid HRD68_16405 ENOG4105DHJ ABC, transporter HRD68_16420 ENOG4105DS1 cytochrome b561 HRD68_16425 ENOG4108YYC ycei family HRD68_16430 ENOG4105DDV Transcriptional regulator (LacI family HRD68_16435 ENOG4105C5Y PTS System HRD68_16440 ENOG4105CS2 ec 3.2.1.21 HRD68_16450 ENOG4105NTW Transcriptional regulator HRD68_16455 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HRD68_16460 ENOG4105HMZ Methyltransferase HRD68_16465 ENOG4105CVK Glutamate decarboxylase HRD68_16470 ENOG4105E5D amino acid HRD68_16485 ENOG41081FY multiple antibiotic resistance (MarC)-related HRD68_16495 ENOG4105BZU Histidine kinase HRD68_16500 ENOG4108WQH regulatoR HRD68_16505 ENOG41076YT nitrate reductase, gamma subunit HRD68_16510 ENOG4105R3A Nitrate reductase HRD68_16515 ENOG4108IUE nitrate reductase beta subunit HRD68_16520 ENOG4105CRU nitrate reductase, alpha subunit HRD68_16525 ENOG4105DQQ Major facilitator superfamily MFS_1 HRD68_16530 ENOG4105WH1 Two component transcriptional regulator luxr family HRD68_16535 ENOG4105CUW cytochrome C-TYPE protein HRD68_16540 ENOG4108J2R molybdopterin oxidoreductase HRD68_16685 ENOG4105CDU Replicative dna helicase HRD68_16745 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HRD68_16920 ENOG4105DFP Integrase HRD68_16930 ENOG4105S64 Formate nitrite transporter HRD68_16940 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HRD68_16945 ENOG41060IM Heme exporter protein HRD68_16950 ENOG4105X3C heme exporter protein HRD68_16955 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HRD68_16960 ENOG4105DA4 cytochrome c-type biogenesis protein HRD68_16965 ENOG4107QX9 Thiol disulfide interChange protein HRD68_16970 ENOG4105KWW Biogenesis protein HRD68_16975 ENOG4105KWW Biogenesis protein HRD68_16980 ENOG410903C (LipO)protein HRD68_16995 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HRD68_17000 ENOG4105KZW UPF0381 protein HRD68_17005 ENOG4105CHU acetyl-coa acetyltransferase HRD68_17010 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HRD68_17015 ENOG4108BY2 phosphohistidine phosphatase HRD68_17025 ENOG4108DG9 Smr protein MutS2 HRD68_17030 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HRD68_17040 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HRD68_17045 ENOG4105EJ9 Membrane HRD68_17050 ENOG4108BPE -transporting atpase HRD68_17055 ENOG4105MH2 YfcL protein HRD68_17060 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HRD68_17065 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRD68_17080 ENOG4105D6F Phosphatase HRD68_17085 ENOG4105F4P )-transporter HRD68_17090 ENOG4106WZ1 flagella biosynthesis regulator HRD68_17100 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HRD68_17110 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HRD68_17135 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HRD68_17145 ENOG4105DQR SNARE associated Golgi HRD68_17150 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HRD68_17155 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HRD68_17160 ENOG4108S3P Sporulation domain protein HRD68_17165 ENOG4105E96 Colicin v production protein HRD68_17170 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HRD68_17175 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HRD68_17180 ENOG4105E89 ABC transporter HRD68_17185 ENOG4105DSP amino acid AbC transporter HRD68_17190 ENOG4106YG3 ABC transporter HRD68_17195 ENOG4108JEH abc transporter atp-binding protein HRD68_17200 ENOG4105ECP epimerase HRD68_17210 ENOG4108RE9 Phosphodiesterase HRD68_17215 ENOG4105PTV Nudix Hydrolase HRD68_17220 ENOG4108K4B hydrolase HRD68_17225 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HRD68_17235 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HRD68_17240 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HRD68_17245 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HRD68_17260 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HRD68_17265 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HRD68_17270 ENOG4105CHW UPF0052 protein HRD68_17275 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HRD68_17280 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HRD68_17285 ENOG4105M00 molybdopterin converting factor, subunit 1 HRD68_17290 ENOG4108ZAF Molybdopterin HRD68_17295 ENOG4105HFZ Membrane HRD68_17300 ENOG4105E0K tonB-dependent siderophore receptor HRD68_17315 ENOG4105CEY Amp-dependent synthetase and ligase HRD68_17320 ENOG4105E8G Major facilitator Superfamily HRD68_17325 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HRD68_17330 ENOG4105E4F Isochorismate synthase HRD68_17335 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HRD68_17340 ENOG4105WQI isochorismatase HRD68_17345 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HRD68_17350 ENOG4107QWP ABC-2 type transporter HRD68_17355 ENOG4107QWP ABC-2 type transporter HRD68_17360 ENOG4105CJ1 ABC, transporter HRD68_17365 ENOG4105D0S secretion protein (HlyD HRD68_17370 ENOG4107MVR Transcriptional regulator HRD68_17375 ENOG4105C1J atp-dependent rna helicase HRD68_17380 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HRD68_17390 ENOG41061WM D-Alanyl-D-Alanine HRD68_17395 ENOG4105CXG d-lactate dehydrogenase HRD68_17405 ENOG4105N1F Hnh endonuclease HRD68_17415 ENOG4105Y3U Transglycosylase-associated protein HRD68_17425 ENOG4105EHI Phosphonate ABC transporter, periplasmic HRD68_17440 ENOG4108W15 Protein of unknown function (DUF1456) HRD68_17445 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HRD68_17450 ENOG4105C32 Amino acid ABC transporter (Permease) HRD68_17455 ENOG4105CNN ABC, transporter HRD68_17465 ENOG4108IV0 ABC, transporter HRD68_17470 ENOG4105KHC sulfurtransferase HRD68_17485 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HRD68_17490 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HRD68_17495 ENOG4108IJ8 ABC transporter HRD68_17500 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HRD68_17510 ENOG4105D5Q Arginine ornithine antiporter HRD68_17515 ENOG4105CXN decarboxylase HRD68_17525 ENOG4105FDR Membrane HRD68_17535 ENOG4105DVT helicase HRD68_17540 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HRD68_17545 ENOG4108MTB glycosyl transferase family HRD68_17555 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HRD68_17560 ENOG4107XC4 flavin reductase domain protein, FMN-binding HRD68_17565 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HRD68_17570 ENOG4107SDU Methyl-accepting chemotaxis HRD68_17575 ENOG4105CDA abc transporter atp-binding protein HRD68_17580 ENOG4105E5Q amino acid AbC transporter HRD68_17585 ENOG4107R0W ABC transporter HRD68_17590 ENOG4105KSC Transcriptional regulator, TraR DksA family HRD68_17595 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HRD68_17600 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HRD68_17630 ENOG4108T1M outer membrane protein x HRD68_17650 ENOG4105C5H ABC transporter HRD68_17655 ENOG4105D06 uba thif-type nad fad binding protein HRD68_17660 ENOG4105CVM Molybdenum cofactor synthesis domain protein HRD68_17670 ENOG4105CSH Transporter HRD68_17685 ENOG4105EGI Transcriptional regulator HRD68_17690 ENOG4105CBP Major Facilitator HRD68_17695 ENOG4105EUJ GTP cyclohydrolase i HRD68_17700 ENOG4105DHF Membrane HRD68_17705 ENOG41060NJ transcriptional regulator HRD68_17720 ENOG4107SDZ Galactoside transport system permease protein mglC HRD68_17725 ENOG4105TMB Formate nitrite transporter HRD68_17730 ENOG4108JUA Transcriptional regulator HRD68_17735 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HRD68_17740 ENOG4108RC0 Electron transport protein HRD68_17745 ENOG4108MG9 hydrogenase 3 maturation protease HRD68_17750 ENOG4105I6X formate hydrogenlyase maturation HRD68_17755 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HRD68_17765 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HRD68_17770 ENOG4108JPZ Monovalent cation H antiporter subunit D HRD68_17775 ENOG4107WQX hydrogenase 4 membrane subunit HRD68_17780 ENOG4105D65 subunit l HRD68_17785 ENOG4107TDF Formate hydrogenlyase subunit 4 HRD68_17790 ENOG4108JPZ Monovalent cation H antiporter subunit D HRD68_17795 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HRD68_17800 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HRD68_17810 ENOG4107GZ4 SanA protein HRD68_17815 ENOG4107R1I NAD-dependent malic enzyme HRD68_17825 ENOG41067MG lrgb family HRD68_17830 ENOG4105VAW lrga family HRD68_17835 ENOG4105E5W Transporter HRD68_17850 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HRD68_17855 ENOG4105D1F ATP-binding protein HRD68_17870 ENOG4108GAE asmA family HRD68_17875 ENOG4105CEE C4-dicarboxylate transporter HRD68_17880 ENOG4105EE5 Membrane protein terC HRD68_17900 ENOG4105EY8 ABC transporter HRD68_17905 ENOG4108KQJ Type 11 methyltransferase HRD68_17915 ENOG4105C0K Gdp-mannose 4,6-dehydratase HRD68_17920 ENOG4108DMA Nad-dependent epimerase dehydratase HRD68_17935 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HRD68_17940 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HRD68_17945 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HRD68_17950 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HRD68_17955 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HRD68_17960 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HRD68_17970 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HRD68_17975 ENOG4105CIH Imidazole acetol-phosphate transaminase HRD68_17980 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HRD68_17985 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HRD68_17995 ENOG4107SRH Nad-dependent epimerase dehydratase HRD68_18000 ENOG4105CNN ABC, transporter HRD68_18005 ENOG4105C2J ABC transporter HRD68_18010 ENOG4107SCQ Iron-containing alcohol dehydrogenase HRD68_18015 ENOG4105CUB amino acid HRD68_18020 ENOG4105CJB Exodeoxyribonuclease I HRD68_18030 ENOG4105DR8 Membrane HRD68_18035 ENOG41090HJ UPF0265 protein HRD68_18045 ENOG4105CNN ABC, transporter HRD68_18055 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HRD68_18060 ENOG4105JZC GHMP kinase HRD68_18065 ENOG4107QZB decarboxylase HRD68_18070 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HRD68_18075 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HRD68_18080 ENOG4105KTW ethanolamine utilization protein HRD68_18085 ENOG4105M3W utilization protein HRD68_18095 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HRD68_18105 ENOG4108EKI Dehydrogenase HRD68_18115 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HRD68_18125 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HRD68_18135 ENOG4105KNY Microcompartments protein HRD68_18145 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HRD68_18150 ENOG4108ZFT Dehydratase small subunit HRD68_18155 ENOG4105YCI dehydratase medium subunit HRD68_18160 ENOG4105DMB glycerol dehydratase HRD68_18165 ENOG4105EHR propanediol utilization protein pduB HRD68_18170 ENOG4105KNY Microcompartments protein HRD68_18175 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HRD68_18180 ENOG4107XVH Transcriptional regulator HRD68_18185 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HRD68_18190 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HRD68_18195 ENOG41081F0 Precorrin-8x methylmutase HRD68_18200 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HRD68_18205 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HRD68_18210 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HRD68_18215 ENOG4105CIA precorrin-4 C(11)-methyltransferase HRD68_18220 ENOG4108P62 biosynthesis protein (CbiG) HRD68_18225 ENOG4105E4R Precorrin-3B C17-methyltransferase HRD68_18230 ENOG4105QUC reductase HRD68_18235 ENOG4107PPM cobalt chelatase HRD68_18240 ENOG4105DVK Precorrin-2 c20-methyltransferase HRD68_18245 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HRD68_18250 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HRD68_18255 ENOG4108V4M Cobalt abc transporter HRD68_18265 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HRD68_18270 ENOG4108YZT Adenosylcobinamide kinase HRD68_18275 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HRD68_18280 ENOG4108TGR phosphatase HRD68_18285 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HRD68_18290 ENOG4105CN8 Transcriptional regulator HRD68_18300 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HRD68_18305 ENOG4105EAA nucleoside HRD68_18310 ENOG4105CDH Citrulline--aspartate ligase HRD68_18315 ENOG4105UQX Mate efflux family protein HRD68_18325 ENOG4105EMU Dehydrogenase HRD68_18330 ENOG4108KSB HipA-like N-terminal domain HRD68_18335 ENOG4105MHH HipA N-terminal domain protein HRD68_18375 ENOG4105FE9 pseudouridine synthase HRD68_18380 ENOG4108MQF Chaperone HRD68_18395 ENOG4105GQR Chaperone HRD68_18405 ENOG4105BZU Histidine kinase HRD68_18410 ENOG4108Q9V regulatoR HRD68_18420 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HRD68_18425 ENOG4107RCV ABC transporter, permease HRD68_18430 ENOG4105C4Y ABC transporter HRD68_18435 ENOG4105CXY transporter HRD68_18440 ENOG4105BZU Histidine kinase HRD68_18445 ENOG4108KX4 response regulator HRD68_18450 ENOG4106YYS transcriptional regulatory protein HRD68_18455 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HRD68_18460 ENOG4105DUA (citrate (pro-3S)-lyase ligase HRD68_18465 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HRD68_18470 ENOG4105CI0 Citrate lyase HRD68_18475 ENOG4105CHY citrate lyase, alpha HRD68_18485 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HRD68_18490 ENOG4107QPK )-transporter HRD68_18495 ENOG4108TSE Transferase HRD68_18505 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HRD68_18510 ENOG4108P2H Inner membrane protein YjiG HRD68_18515 ENOG41074DU domain protein HRD68_18525 ENOG4107QPK )-transporter HRD68_18530 ENOG4105JSC dimethylmenaquinone methyltransferase HRD68_18540 ENOG4107F9Y LysR family transcriptional regulator HRD68_18550 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HRD68_18555 ENOG4105D3G Pseudouridine synthase HRD68_18605 ENOG4108YS1 cytoplasmic protein HRD68_18615 ENOG4105EW9 transcriptional regulator AsnC family HRD68_18630 ENOG4105CBN LysR family transcriptional regulator HRD68_18660 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HRD68_18665 ENOG4105D6F Phosphatase HRD68_18670 ENOG41061EV selenium-binding protein YdfZ HRD68_18680 ENOG4105J0Q Transcriptional regulator HRD68_18685 ENOG4105GSJ Inner membrane protein ylaC HRD68_18695 ENOG4105CNT hydrolase family 2 HRD68_18700 ENOG4105ETE Transcriptional regulator (LacI family HRD68_18710 ENOG4105VZF DsrB protein HRD68_18715 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_18720 ENOG4105KT7 mgtC SapB transporter HRD68_18725 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HRD68_18730 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HRD68_18735 ENOG4108VA4 Universal stress protein HRD68_18745 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HRD68_18750 ENOG4107RD7 Flagellar Motor Protein, MotA HRD68_18755 ENOG4105ER2 Ompa motb domain protein HRD68_18760 ENOG4105CBS Chea signal transduction histidine kinase HRD68_18765 ENOG4108V3W Chemotaxis protein, CheW HRD68_18770 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_18775 ENOG4105C8Q Methyl-accepting chemotaxis HRD68_18780 ENOG4105BZU Histidine kinase HRD68_18790 ENOG4108VYJ response regulator receiver protein HRD68_18795 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HRD68_18800 ENOG4105D00 flagellar biosynthetic protein flhB HRD68_18805 ENOG4105D7B Flagellar biosynthesis protein flha HRD68_18810 ENOG4105W13 flagellar protein HRD68_18820 ENOG4105QVD Flagella synthesis protein FlgN HRD68_18825 ENOG4105M9M anti-sigma28 factor FlgM HRD68_18830 ENOG4105CKS Flagella basal body P-ring formation protein flgA HRD68_18835 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HRD68_18840 ENOG4108ZC9 flagellar basal-body rod protein flgc HRD68_18845 ENOG4105W00 Flagellar hook capping protein HRD68_18850 ENOG4105BZE flagellar hook protein, FlgE HRD68_18855 ENOG4108KPB Flagellar basal-body rod protein FlgF HRD68_18860 ENOG4105CGA flagellar basal-body rod protein FlgG HRD68_18875 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HRD68_18880 ENOG4105E1Q flagellar hook-associated protein HRD68_18885 ENOG4105DTJ flagellar hook-associated protein HRD68_18890 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HRD68_18895 ENOG4105VS8 Flagellar biosynthetic protein fliq HRD68_18900 ENOG4105CN7 Flagellar biosynthetic protein FliP HRD68_18910 ENOG4105DD5 Flagellar motor switch protein HRD68_18915 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HRD68_18920 ENOG4107ZI8 flagellar basal body-associated protein flil HRD68_18925 ENOG4105WF4 Flagellar hook-length control protein HRD68_18930 ENOG4105GSA Flagellar export protein flij HRD68_18935 ENOG4108JIR Flagellum-specific ATP synthase HRD68_18940 ENOG41090PJ Flagellar assembly protein HRD68_18945 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HRD68_18950 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HRD68_18955 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HRD68_18965 ENOG4105DHT Metal Dependent Phosphohydrolase HRD68_18970 ENOG4108NKV transcriptional regulator HRD68_18975 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HRD68_18980 ENOG4105MQ3 flagellar protein FliS HRD68_18985 ENOG4105DTS flagellar hook-associated HRD68_18995 ENOG4108C80 FliB family HRD68_19000 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HRD68_19005 ENOG4108M9K flagella biosynthesis protein FliZ HRD68_19010 ENOG4105K6H D-cysteine desulfhydrase HRD68_19015 ENOG4105EAB amino acid AbC transporter HRD68_19020 ENOG4105E5Q amino acid AbC transporter HRD68_19025 ENOG4105CDA abc transporter atp-binding protein HRD68_19040 ENOG4105C26 Dehydrogenase HRD68_19045 ENOG4105CK7 Sodium proline symporter HRD68_19050 ENOG4105EKT )-iron permease HRD68_19055 ENOG410650H (LipO)protein HRD68_19075 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) HRD68_19080 ENOG4105C2W permease HRD68_19085 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HRD68_19090 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HRD68_19095 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HRD68_19100 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HRD68_19105 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HRD68_19110 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HRD68_19115 ENOG4108R86 Transcriptional regulator HRD68_19130 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HRD68_19145 ENOG4105E5K Alpha-amylase HRD68_19155 ENOG4105RA2 Membrane HRD68_19160 ENOG4105XVG cytoplasmic protein HRD68_19165 ENOG4105WH1 Two component transcriptional regulator luxr family HRD68_19170 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HRD68_19175 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HRD68_19205 ENOG4108R7K Metal Dependent Phosphohydrolase HRD68_19225 ENOG4108S1U HRD68_19235 ENOG4105CAR Terminase, large subunit HRD68_19245 ENOG4108ZUE Phage regulatory protein rha HRD68_19250 ENOG4108MXB Protein of unknown function (DUF968) HRD68_19265 ENOG4105NVB glycoside hydrolase, family 19 HRD68_19295 ENOG4105CAR Terminase, large subunit HRD68_19305 ENOG4105EFC phage portal protein HK97 family HRD68_19435 ENOG4105CEE C4-dicarboxylate transporter HRD68_19440 ENOG4108Q3X Transcriptional regulator HRD68_19445 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HRD68_19475 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HRD68_19490 ENOG4105ECR NmrA family HRD68_19495 ENOG4105KVH Transcriptional regulator HRD68_19510 ENOG4107QZW Altronate oxidoreductase HRD68_19515 ENOG4105CPQ Dehydrogenase HRD68_19520 ENOG410617M Transcriptional regulator HRD68_19525 ENOG4108I5G Major Facilitator superfamily HRD68_19530 ENOG4105DWP Membrane HRD68_19535 ENOG4105ECQ AraC Family Transcriptional Regulator HRD68_19545 ENOG4105XXV Acid-resistance protein HRD68_19565 ENOG4105BZ1 (ABC) transporter HRD68_19570 ENOG4105D5Q Arginine ornithine antiporter HRD68_19585 ENOG4105N4N Protein of unknown function (DUF2766) HRD68_19590 ENOG4105TIK HRD68_19600 ENOG41064PC HRD68_19615 ENOG4105C85 amino acid HRD68_19620 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HRD68_19635 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HRD68_19640 ENOG4105CJN penicillin-binding protein HRD68_19655 ENOG4105BZU Histidine kinase HRD68_19665 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HRD68_19675 ENOG4105F3R pts system mannose fructose sorbose family iid HRD68_19680 ENOG4105ETZ PTS System HRD68_19685 ENOG4105DAS pts system HRD68_19690 ENOG4105EE5 Membrane protein terC HRD68_19700 ENOG4105EJQ L-serine dehydratase HRD68_19705 ENOG4105P8F nudix hydrolase HRD68_19715 ENOG4105X5C UPF0181 protein HRD68_19720 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HRD68_19725 ENOG4105C1J atp-dependent rna helicase HRD68_19730 ENOG4105X2V dna damage-inducible protein HRD68_19745 ENOG4105CUG Oligopeptidase b HRD68_19750 ENOG4105UMD exodeoxyribonuclease X HRD68_19765 ENOG4105MPK DNA polymerase III subunit theta HRD68_19770 ENOG41090A1 ferritin HRD68_19775 ENOG4105FXM Copper resistance protein HRD68_19780 ENOG4108PNC copper resistance HRD68_19785 ENOG4105NKT exported protein HRD68_19795 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HRD68_19835 ENOG4108SHQ Glutathione S-transferase HRD68_19855 ENOG4105WT8 Protein of unknown function (DUF1480) HRD68_19905 ENOG4105DY2 Paraquat-inducible protein b HRD68_19910 ENOG4105H2K paraquat-inducible protein a HRD68_19915 ENOG4108ZGC gaf domain protein HRD68_19920 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HRD68_19925 ENOG4105CN1 protease HRD68_19930 ENOG4105D0M Protease HtpX homolog HRD68_19935 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRD68_19940 ENOG4105CAZ oligogalacturonide lyase HRD68_19950 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HRD68_19955 ENOG4108ETY sodium dicarboxylate symporter HRD68_19960 ENOG4107K5X Membrane-bound metal-dependent hydrolase HRD68_19965 ENOG4108PU9 oligogalacturonate-specific porin HRD68_19975 ENOG4108IJ9 (ABC) transporter HRD68_19980 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HRD68_19985 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HRD68_19990 ENOG41061NF Pectate lyase HRD68_19995 ENOG4105CHR reductase HRD68_20000 ENOG4105M5J Cupin 2, conserved barrel domain protein HRD68_20005 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HRD68_20010 ENOG4107PN8 YfeABCD locus regulator HRD68_20020 ENOG4105CC5 ABC transporter HRD68_20025 ENOG4105CC5 ABC transporter HRD68_20030 ENOG4105DIK (ABC) transporter HRD68_20035 ENOG4105DSE periplasmic solute binding protein HRD68_20045 ENOG41082NP Multiple antibiotic resistance HRD68_20060 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HRD68_20065 ENOG4105H6Q decarboxylase HRD68_20070 ENOG4105CMG Carbohydrate kinase HRD68_20075 ENOG4105DG4 malate L-lactate dehydrogenase HRD68_20090 ENOG4105CNN ABC, transporter HRD68_20095 ENOG4105C2J ABC transporter HRD68_20100 ENOG4105J4Q Transcriptional regulator HRD68_20105 ENOG4108UQV Membrane HRD68_20110 ENOG41087WU HRD68_20115 ENOG4105VRE Pentapeptide repeat protein HRD68_20155 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HRD68_20160 ENOG4105ED1 spovr family HRD68_20165 ENOG4105MWK D-amino acid dehydrogenase, small subunit HRD68_20170 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HRD68_20175 ENOG4105DHQ Histidine kinase HRD68_20180 ENOG4105XJC Two component transcriptional regulator (Winged helix family HRD68_20185 ENOG4105H4F exported protein HRD68_20190 ENOG4105CNH Multidrug resistance protein MdtL HRD68_20195 ENOG4105BZU Histidine kinase HRD68_20200 ENOG4105EUB pirin domain protein HRD68_20205 ENOG4105HEI LysR family (Transcriptional regulator HRD68_20215 ENOG4106AKX UPF0229 protein HRD68_20220 ENOG4105CYN Serine protein kinase HRD68_20225 ENOG4105GNX MltA-interacting MipA family protein HRD68_20230 ENOG4105DSB aldose 1-epimerase HRD68_20255 ENOG4105VUT cytoplasmic protein HRD68_20260 ENOG4108RWI nicotinamidase HRD68_20265 ENOG4105HDK L-asparaginase HRD68_20270 ENOG4105D07 Signal peptide peptidase, SppA HRD68_20275 ENOG41069NU Nitroreductase HRD68_20285 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HRD68_20290 ENOG4105MTM Protein of unknown function (DUF1496) HRD68_20295 ENOG4105M6F mutator MutT protein HRD68_20300 ENOG4105CGK Exodeoxyribonuclease III HRD68_20305 ENOG4105SKE transcriptional Regulator LysR family HRD68_20325 ENOG4105CIY formyltetrahydrofolate deformylase HRD68_20330 ENOG4105K5B UPF0225 protein HRD68_20340 ENOG4105D78 K07001 NTE family protein HRD68_20345 ENOG4105I93 response regulator HRD68_20350 ENOG4105C6Y Udp-glucose 6-dehydrogenase HRD68_20365 ENOG4105C0A alcohol dehydrogenase HRD68_20370 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HRD68_20375 ENOG4108J59 Extracellular solute-binding protein, family 5 HRD68_20380 ENOG4107QSI ABC, transporter HRD68_20385 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HRD68_20390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HRD68_20395 ENOG4105C3U ABC transporter HRD68_20400 ENOG4108JQ7 (ABC) transporter HRD68_20405 ENOG4108W5H UPF0263 protein HRD68_20410 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HRD68_20420 ENOG4105CMB EAL domain-containing protein HRD68_20430 ENOG4105K9H YciI-like protein HRD68_20435 ENOG410822N TonB family HRD68_20440 ENOG4105NAU thioesterase Superfamily protein HRD68_20445 ENOG4107835 probably involved in intracellular septation (By similarity) HRD68_20455 ENOG4108S3I UPF0259 membrane protein HRD68_20460 ENOG4105EIF outer membrane protein W HRD68_20470 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HRD68_20475 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HRD68_20480 ENOG4105DK0 Indole-3-glycerol phosphate synthase HRD68_20490 ENOG4105DDQ anthranilate synthase HRD68_20505 ENOG4105DB7 PHP domain protein HRD68_20510 ENOG4107RTD sua5 ycio yrdc ywlc family protein HRD68_20520 ENOG4108Q9V regulatoR HRD68_20530 ENOG4105FE9 pseudouridine synthase HRD68_20535 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HRD68_20540 ENOG4105UBK short-chain dehydrogenase reductase HRD68_20545 ENOG4105ERU peptidase HRD68_20550 ENOG4105RKX Protein of unknown function (DUF2498) HRD68_20555 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HRD68_20560 ENOG4107R11 Transcriptional regulator HRD68_20570 ENOG4107QM5 aconitate hydratase HRD68_20580 ENOG4105EYK Phosphatidylglycerophosphatase B HRD68_20585 ENOG4105Q4A inner membrane protein yciS HRD68_20590 ENOG4105CFV Tetratricopeptide repeat protein HRD68_20600 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HRD68_20605 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HRD68_20610 ENOG4108ZJT translation initiation factor, Sui1 HRD68_20615 ENOG41061RM osmotically inducible lipoprotein HRD68_20620 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HRD68_20630 ENOG4105N2W Transcriptional regulator HRD68_20645 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HRD68_20650 ENOG4105VCD cytoplasmic protein HRD68_20655 ENOG4105D22 carbon starvation protein HRD68_20660 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HRD68_20665 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HRD68_20670 ENOG4105CSM endonuclease III HRD68_20680 ENOG4108UQQ Electron transport complex HRD68_20690 ENOG4105UEI Transcriptional Regulator AraC Family HRD68_20705 ENOG4105DGN Electron transport complex HRD68_20710 ENOG4105M9B inner membrane protein ydgK HRD68_20715 ENOG4105CKU formyltetrahydrofolate synthetase HRD68_20730 ENOG4108JJA ABC, transporter HRD68_20735 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HRD68_20740 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HRD68_20750 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HRD68_20755 ENOG4105C2J ABC transporter HRD68_20760 ENOG4105CNN ABC, transporter HRD68_20770 ENOG4105D9R oxidoreductase HRD68_20775 ENOG4105DHU Bile acid HRD68_20780 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HRD68_20785 ENOG4105C87 Aminotransferase class I and II HRD68_20790 ENOG4105CI1 PTS System HRD68_20795 ENOG4107P2S Transcriptional regulator HRD68_20815 ENOG4106J39 exported protein HRD68_20820 ENOG4105EIP mannose-6-phosphate isomerase HRD68_20825 ENOG4105C9Q fumarate hydratase class II HRD68_20830 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HRD68_20840 ENOG4105D94 Major Facilitator Superfamily HRD68_20845 ENOG4106NZI LysR family Transcriptional regulator HRD68_20850 ENOG4105DAG ROK family HRD68_20855 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HRD68_20865 ENOG4105KBG Protein of unknown function (DUF1161) HRD68_20870 ENOG4105M5Q UPF0482 protein HRD68_20875 ENOG4105KK4 UPF0060 membrane protein HRD68_20880 ENOG4105EMU Dehydrogenase HRD68_20885 ENOG4105C0R drug resistance transporter emrb qaca subfamily HRD68_20890 ENOG4105TDT uncharacterized protein yahO HRD68_20925 ENOG4105CYM Glutathione S-transferase HRD68_20935 ENOG4108RYR transcriptional regulator AsnC family HRD68_20945 ENOG4105DSP amino acid AbC transporter HRD68_20950 ENOG4105E89 ABC transporter HRD68_20955 ENOG4106V2I dimethylaminohydrolase HRD68_20960 ENOG4105FYV Amp nucleosidase HRD68_20985 ENOG4105CVK Glutamate decarboxylase HRD68_20990 ENOG4105E5D amino acid HRD68_21000 ENOG4105PAD Hydrolase HRD68_21035 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) HRD68_21050 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HRD68_21055 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HRD68_21060 ENOG4105Q9Y Universal stress protein HRD68_21065 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HRD68_21070 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HRD68_21075 ENOG4105C5D exported protein HRD68_21080 ENOG4105D5Q Arginine ornithine antiporter HRD68_21090 ENOG4107EXC regulatoR HRD68_21095 ENOG4105JJR Histidine kinase HRD68_21100 ENOG4105CTD carboxy-peptidase HRD68_21110 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HRD68_21120 ENOG4105MRD Phage derived protein Gp49-like (DUF891) HRD68_21125 ENOG4105CQ7 ATP-dependent helicase HRD68_21130 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HRD68_21135 ENOG4105CSH Transporter HRD68_21145 ENOG4105HVQ Regulatory factor of maltose metabolism HRD68_21155 ENOG4105DEI Mannitol dehydrogenase HRD68_21160 ENOG4105CMG Carbohydrate kinase HRD68_21165 ENOG4105IE8 Alpha-ketoglutarate permease HRD68_21170 ENOG4105WXT Conserved Protein HRD68_21175 ENOG410689M (LipO)protein HRD68_21180 ENOG4107H52 Dicarboxylate transport HRD68_21185 ENOG4105C5I Dehydrogenase HRD68_21190 ENOG4105IKK cytoplasmic protein HRD68_21200 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HRD68_21205 ENOG4105CS2 ec 3.2.1.21 HRD68_21210 ENOG4105C5Y PTS System HRD68_21215 ENOG4105CID antiterminator HRD68_21220 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HRD68_21230 ENOG4107QSI ABC, transporter HRD68_21235 ENOG4105KXI murein peptide amidase A HRD68_21240 ENOG4107S8C mandelate racemase muconate lactonizing HRD68_21245 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HRD68_21265 ENOG4106K28 UPF0283 membrane protein HRD68_21270 ENOG4105CM6 amino acid regulated cytosolic protein HRD68_21280 ENOG4105FM1 phage shock protein C HRD68_21285 ENOG4105YYT phage shock protein B HRD68_21290 ENOG41087YS Phage shock protein A HRD68_21295 ENOG4105E51 psp operon transcriptional activator HRD68_21300 ENOG4108HIY periplasmic HRD68_21305 ENOG4108EKA peptide transport system, permease HRD68_21310 ENOG4108EU3 peptide transport system, permease HRD68_21315 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HRD68_21320 ENOG4108JQ2 peptide transport system atp-binding protein HRD68_21325 ENOG4105Q4T oxidoreductase HRD68_21330 ENOG4105DUX Transporter HRD68_21345 ENOG41069YE inner membrane protein yohC HRD68_21350 ENOG4108ZR5 Conserved Protein HRD68_21355 ENOG4108K3A Glutathione S-transferase HRD68_21365 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HRD68_21375 ENOG410642K Lysozyme inhibitor HRD68_21380 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HRD68_21385 ENOG4108XTF Outer Membrane Lipoprotein HRD68_21390 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) HRD68_21400 ENOG4105Y49 secretion protein, HlyD family HRD68_21405 ENOG4105DSW Fusaric acid resistance protein HRD68_21410 ENOG4107RGM aldo keto reductase HRD68_21415 ENOG4105XZD Fe-S protein HRD68_21420 ENOG4105DIJ Phosphoethanolamine transferase HRD68_21425 ENOG4108WUH Transcriptional regulator, TetR family HRD68_21430 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HRD68_21435 ENOG4108UYE Lactoylglutathione lyase HRD68_21440 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HRD68_21445 ENOG4105M2J Glutaredoxin HRD68_21450 ENOG4105K4H Nlp p60 protein HRD68_21455 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HRD68_21465 ENOG4105ETE Transcriptional regulator (LacI family HRD68_21470 ENOG4105F52 Transcriptional regulator HRD68_21475 ENOG4105CZQ inner membrane transport protein YdhC HRD68_21480 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HRD68_21485 ENOG4108R6K riboflavin synthase, subunit alpha HRD68_21490 ENOG4107QI1 Mate efflux family protein HRD68_21505 ENOG4105CA9 Pyruvate kinase HRD68_21515 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HRD68_21520 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HRD68_21530 ENOG4105JRK feS assembly protein SufD HRD68_21535 ENOG4105C3K feS assembly ATPase SufC HRD68_21540 ENOG4105DIW FeS assembly protein SUFB HRD68_21545 ENOG4108Z4V iron-sulfur cluster assembly HRD68_21550 ENOG4105KA0 thioesterase Superfamily protein HRD68_21555 ENOG4105CQB FAD linked oxidase domain protein HRD68_21560 ENOG4105IPI Membrane HRD68_21570 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HRD68_21575 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HRD68_21580 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HRD68_21590 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HRD68_21595 ENOG4108QBX (LipO)protein HRD68_21600 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HRD68_21610 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HRD68_21615 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HRD68_21625 ENOG4105CKK Glycosyl transferase, family 2 HRD68_21630 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HRD68_21635 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HRD68_21640 ENOG4108V06 Glutathione peroxidase HRD68_21645 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HRD68_21655 ENOG4107TT5 NLP P60 protein HRD68_21660 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) HRD68_21665 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HRD68_21670 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HRD68_21680 ENOG4108ZZ3 UPF0260 protein HRD68_21685 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HRD68_21690 ENOG4105VNG YcgL domain-containing protein HRD68_21695 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HRD68_21700 ENOG4107QMS site-determining protein HRD68_21705 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HRD68_21710 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HRD68_21715 ENOG4105CEY Amp-dependent synthetase and ligase HRD68_21720 ENOG4105Y4Z Outer Membrane Lipoprotein HRD68_21725 ENOG41072GX Peptidase M22 Glycoprotease HRD68_21730 ENOG4105DVT helicase HRD68_21735 ENOG4105M4H endoribonuclease L-psp HRD68_21745 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HRD68_21750 ENOG4108M1A Chitin-binding protein HRD68_21755 ENOG4108UHU Aldolase HRD68_21760 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HRD68_21765 ENOG4106KNT transcriptional regulator HRD68_21770 ENOG4105CA9 Pyruvate kinase HRD68_21775 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HRD68_21780 ENOG4105DR5 peptidase HRD68_21785 ENOG4105NXV High-affinity zinc uptake system protein HRD68_21790 ENOG4105FDK ABC transporter HRD68_21795 ENOG4105FAV ABC, transporter HRD68_21800 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HRD68_21805 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HRD68_21815 ENOG4105CDY transcriptional regulatory protein HRD68_21820 ENOG4108TIT dATP pyrophosphohydrolase HRD68_21825 ENOG4105C9M aspartyl-trna synthetase HRD68_21830 ENOG4105D3W isochorismatase HRD68_21835 ENOG41081XQ Conserved Protein HRD68_21840 ENOG4105WJG Glutathione HRD68_21850 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HRD68_21855 ENOG4106N3A copper homeostasis protein cutc HRD68_21860 ENOG4106ZCM YecM protein HRD68_21870 ENOG4105CJR Integral membrane protein (MviN HRD68_21875 ENOG4105EP9 oxidoreductase HRD68_21885 ENOG4105D9U N-acetyltransferase HRD68_21890 ENOG4105EV4 Multidrug resistance protein mdtH HRD68_21895 ENOG4105F3T (LipO)protein HRD68_21900 ENOG4107XHZ cytoplasmic chaperone TorD family protein HRD68_21910 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HRD68_21925 ENOG4105BZU Histidine kinase HRD68_21930 ENOG4105CHH sulfate transporter HRD68_21940 ENOG41063JG Transcriptional regulator HRD68_21945 ENOG4108YY7 Invasion gene expression up-regulator SirB HRD68_21950 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HRD68_21955 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HRD68_21960 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HRD68_21965 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HRD68_21975 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HRD68_21980 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HRD68_21985 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HRD68_21995 ENOG4105C3G gtp-binding protein HRD68_22000 ENOG4105DFP Integrase HRD68_22045 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HRD68_22050 ENOG4108XS9 dna repair protein HRD68_22070 ENOG4105HVQ Regulatory factor of maltose metabolism HRD68_22110 ENOG4105DVF Cytosine-specific methyltransferase HRD68_22130 ENOG4105DTA methyltransferase HRD68_22135 ENOG4105D5K Hemolysin activator protein HRD68_22140 ENOG4105CKT filamentous hemagglutinin HRD68_22185 ENOG4105D6U Sodium Glutamate Symporter HRD68_22190 ENOG4107B2H carbonic anhydrase HRD68_22220 ENOG4107SET aldo keto reductase HRD68_22225 ENOG4105CEY Amp-dependent synthetase and ligase HRD68_22230 ENOG41090P5 ferredoxin-like protein HRD68_22235 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HRD68_22240 ENOG4105C10 Electron transfer flavoprotein HRD68_22245 ENOG4105CV7 Electron transfer flavoprotein HRD68_22250 ENOG4105W4W Transcriptional regulator HRD68_22255 ENOG4105C1G acyl-Coa dehydrogenase HRD68_22260 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HRD68_22275 ENOG4105EMV Major Facilitator HRD68_22280 ENOG4105DND Transcriptional regulator HRD68_22285 ENOG4105EMV Major Facilitator HRD68_22290 ENOG4105SUA Ydil protein HRD68_22295 ENOG4108K5P (LipO)protein HRD68_22305 ENOG4108MEK Metal-binding protein YodA HRD68_22310 ENOG4108HWV )-transporter HRD68_22315 ENOG4105C2J ABC transporter HRD68_22330 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HRD68_22335 ENOG4105CZE histidine utilization repressor HRD68_22340 ENOG4105CI2 imidazolone-5-propionate hydrolase HRD68_22355 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HRD68_22360 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HRD68_22370 ENOG4105F4X arginine HRD68_22375 ENOG4105C8Y Acetylornithine aminotransferase HRD68_22380 ENOG4108J20 pectate lyase HRD68_22385 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HRD68_22390 ENOG4105C4M (Ubiquinol oxidase) subunit I HRD68_22395 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HRD68_22405 ENOG4105BZU Histidine kinase HRD68_22410 ENOG4107R11 Transcriptional regulator HRD68_22420 ENOG4105EWV Sodium calcium exchanger membrane region HRD68_22425 ENOG4105D5M phosphate starvation-inducible protein HRD68_22440 ENOG4105CND Glycosyl transferase, family 2 HRD68_22445 ENOG4107BJW polysaccharide deacetylase HRD68_22450 ENOG4108TUY outer membrane protein PgaA HRD68_22455 ENOG4105H1N peptidase, M24 HRD68_22465 ENOG4105EXG Transcriptional regulator HRD68_22485 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HRD68_22495 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HRD68_22510 ENOG4107SJW iron permease, FTR1 HRD68_22520 ENOG4105VCP PTS System HRD68_22525 ENOG4105CS2 ec 3.2.1.21 HRD68_22530 ENOG4105CK1 PTS System HRD68_22535 ENOG4105VZJ PTS System HRD68_22540 ENOG4105DDV Transcriptional regulator (LacI family HRD68_22555 ENOG4105CSV Glutaminase HRD68_22560 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HRD68_22565 ENOG4108MRH transcriptional regulatory protein HRD68_22575 ENOG4105C85 amino acid HRD68_22580 ENOG4105K78 MarR family Transcriptional regulator HRD68_22590 ENOG4106UW1 Major Facilitator superfamily HRD68_22595 ENOG4108HCJ Hydrolase HRD68_22615 ENOG4108HMX isocitrate dehydrogenase (NADP) HRD68_22620 ENOG4108R99 pseudouridine synthase HRD68_22630 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HRD68_22635 ENOG41075W9 High frequency lysogenization protein HflD homolog HRD68_22640 ENOG4107QTF adenylosuccinate lyase HRD68_22650 ENOG4105XJC Two component transcriptional regulator (Winged helix family HRD68_22655 ENOG4105IFJ Histidine kinase HRD68_22660 ENOG4105EZE Cupin 4 family protein HRD68_22675 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HRD68_22680 ENOG4105D60 lipoprotein releasing system transmembrane protein HRD68_22690 ENOG4105D60 lipoprotein releasing system transmembrane protein HRD68_22695 ENOG4108JA2 transcriptioN-repair coupling factor HRD68_22700 ENOG4107MBR 17 kDa surface antigen HRD68_22705 ENOG4105CEP NADH dehydrogenase HRD68_22710 ENOG4105D0Y UPF0227 protein HRD68_22725 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HRD68_22730 ENOG41090DQ Lipoprotein HRD68_22735 ENOG4105K59 histidine triad (HIT) protein HRD68_22740 ENOG4105F9E Shikimate 5-dehydrogenase HRD68_22750 ENOG4105CI1 PTS System HRD68_22755 ENOG4105F8V Hydrolase, tatD family HRD68_22760 ENOG4107QRG dna polymerase iii HRD68_22765 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HRD68_22770 ENOG4105HHA aminodeoxychorismate lyase HRD68_22775 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HRD68_22780 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HRD68_22790 ENOG4105CHR reductase HRD68_22795 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HRD68_22805 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HRD68_22810 ENOG4105VGS 50s ribosomal protein l32 HRD68_22815 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HRD68_22825 ENOG4105EI2 Pseudouridine synthase HRD68_22830 ENOG4107QQB Ribonuclease E HRD68_22835 ENOG41067V3 Antibiotic biosynthesis monooxygenase HRD68_22840 ENOG4105EKE dihydroorotase HRD68_22850 ENOG4105PVA Biofilm formation regulatory protein BssS HRD68_22860 ENOG4105WH1 Two component transcriptional regulator luxr family HRD68_22870 ENOG4105DSF transport protein HRD68_22890 ENOG4105DB1 molybdopterin oxidoreductase HRD68_22895 ENOG4106WHD Tetrathionate reductase HRD68_22900 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HRD68_22905 ENOG4106AFQ Histidine kinase HRD68_22910 ENOG4108ZXC Two component transcriptional regulator, luxr family HRD68_22915 ENOG4105D1S lipid A biosynthesis HRD68_22920 ENOG4108VGI doxx family HRD68_22925 ENOG4105C6X Major Facilitator HRD68_22930 ENOG4105DUX Transporter HRD68_22940 ENOG4105NAC (LipO)protein HRD68_22945 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HRD68_22950 ENOG4105DJ9 glucan biosynthesis protein HRD68_22965 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HRD68_22975 ENOG4107YC3 synthase HRD68_22980 ENOG4105VJY transcriptional regulator HRD68_22985 ENOG4108DMF Cytochrome C biogenesis protein HRD68_22995 ENOG4107QX9 Thiol disulfide interChange protein HRD68_23000 ENOG4105DA4 cytochrome c-type biogenesis protein HRD68_23005 ENOG4105DVI reductase, NrfD HRD68_23010 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HRD68_23015 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HRD68_23020 ENOG4105EAU Plays a role in nitrite reduction (By similarity) HRD68_23040 ENOG4105CE4 GlcNAc 6-P deacetylase HRD68_23045 ENOG4105C83 adenylosuccinate lyase HRD68_23050 ENOG4105CI1 PTS System HRD68_23060 ENOG4108YZG isomerase HRD68_23065 ENOG4105NYY transcriptional regulator, RpiR HRD68_23070 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HRD68_23075 ENOG4105C2J ABC transporter HRD68_23080 ENOG4105CNN ABC, transporter HRD68_23085 ENOG4105UP7 3-epimerase HRD68_23090 ENOG4107TFG D-allose kinase HRD68_23095 ENOG4105E98 transcriptional regulator DeoR family HRD68_23105 ENOG4105EDR glucose galactose transporter HRD68_23115 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HRD68_23125 ENOG4105Y50 Virulence Protein HRD68_23140 ENOG4105UZW Tail fiber assembly protein