locus-tag	class	description
HRD68_00050	COG3121	Chaperone
HRD68_00055	COG3188	usher protein
HRD68_00075	COG1393	Belongs to the ArsC family
HRD68_00170	COG3504	Conjugal transfer protein
HRD68_00175	COG3736	Type IV secretory pathway, component VirB8
HRD68_00195	COG4115	mRNA cleavage
HRD68_00200	COG2161	toxin-antitoxin pair type II binding
HRD68_00245	COG1192	Involved in chromosome partitioning
HRD68_00265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRD68_00370	COG3311	Transcriptional regulator
HRD68_00375	COG1569	PIN domain
HRD68_00395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRD68_00400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRD68_00480	COG1609	Transcriptional regulator
HRD68_00490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRD68_00660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HRD68_00805	COG3093	addiction module antidote protein HigA
HRD68_00810	COG3549	Plasmid maintenance system killer
HRD68_00955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRD68_00970	COG0741	lytic transglycosylase activity
HRD68_01120	COG4386	tail sheath protein
HRD68_01295	COG0582	viral genome integration into host DNA
HRD68_01305	COG2920	part of a sulfur-relay system
HRD68_01310	COG1254	Belongs to the acylphosphatase family
HRD68_01320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRD68_01325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRD68_01330	COG3785	DNA binding
HRD68_01335	COG1832	CoA-binding protein
HRD68_01345	COG1803	Methylglyoxal synthase
HRD68_01350	COG0210	DNA helicase
HRD68_01355	COG3304	Inner membrane component domain
HRD68_01360	COG1289	transmembrane transporter activity
HRD68_01365	COG3070	regulator of competence-specific genes
HRD68_01370	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
HRD68_01380	COG3120	sequence-specific DNA binding
HRD68_01385	COG1067	ATP-dependent peptidase activity
HRD68_01390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRD68_01400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD68_01405	COG3130	regulation of translation
HRD68_01410	COG3009	Protein conserved in bacteria
HRD68_01415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRD68_01415	COG3008	intermembrane lipid transfer
HRD68_01420	COG2995	paraquat-inducible protein a
HRD68_01425	COG0488	(ABC) transporter
HRD68_01430	COG0116	Belongs to the methyltransferase superfamily
HRD68_01430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRD68_01435	COG0633	Ferredoxin
HRD68_01435	COG3217	Mosc domain protein beta barrel domain protein
HRD68_01445	COG0167	dihydroorotate dehydrogenase activity
HRD68_01450	COG0308	aminopeptidase N
HRD68_01455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HRD68_01460	COG0017	Asparaginyl-tRNA synthetase
HRD68_01470	COG1448	Aminotransferase
HRD68_01475	COG2200	EAL domain
HRD68_01480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD68_01485	COG3108	Peptidase M15
HRD68_01490	COG2989	Protein conserved in bacteria
HRD68_01505	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HRD68_01510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD68_01515	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HRD68_01520	COG3173	Aminoglycoside phosphotransferase
HRD68_01530	COG2835	tetraacyldisaccharide 4'-kinase activity
HRD68_01535	COG1278	Cold shock
HRD68_01540	COG5383	Protein conserved in bacteria
HRD68_01560	COG0776	regulation of translation
HRD68_01565	COG0539	negative regulation of cytoplasmic translation
HRD68_01575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRD68_01585	COG2323	membrane
HRD68_01590	COG0252	asparaginase activity
HRD68_01595	COG1944	ATP diphosphatase activity
HRD68_01600	COG2116	formate transmembrane transporter activity
HRD68_01605	COG1882	Formate acetyltransferase
HRD68_01610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRD68_01615	COG2814	Major facilitator Superfamily
HRD68_01620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRD68_01625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRD68_01630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HRD68_01635	COG1674	ftsk spoiiie
HRD68_01635	COG3107	peptidoglycan biosynthetic process
HRD68_01645	COG0492	ferredoxin-NADP+ reductase activity
HRD68_01650	COG4988	ABC transporter
HRD68_01655	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HRD68_01660	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HRD68_01665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRD68_01670	COG0542	response to heat
HRD68_01675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRD68_01680	COG1278	Cold shock
HRD68_01690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_01695	COG2990	Protein conserved in bacteria
HRD68_01700	COG3593	DNA synthesis involved in DNA repair
HRD68_01705	COG2431	L-lysine efflux transmembrane transporter activity
HRD68_01710	COG1151	hydroxylamine reductase activity
HRD68_01715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD68_01720	COG0028	Belongs to the TPP enzyme family
HRD68_01730	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HRD68_01735	COG0702	epimerase
HRD68_01740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD68_01750	COG1605	Chorismate mutase
HRD68_01755	COG1126	abc transporter atp-binding protein
HRD68_01760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_01765	COG4215	(ABC) transporter
HRD68_01770	COG4160	amino acid transport
HRD68_01775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_01790	COG1177	transmembrane transport
HRD68_01795	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRD68_01800	COG3842	ATPase activity
HRD68_01805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HRD68_01825	COG2985	domain, Protein
HRD68_01825	COG0569	domain protein
HRD68_01840	COG5464	transposase or invertase
HRD68_01850	COG0671	phosphoesterase, PA-phosphatase related
HRD68_01855	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRD68_01860	COG1349	DNA-binding transcription factor activity
HRD68_01865	COG0814	amino acid
HRD68_01870	COG1760	l-serine dehydratase
HRD68_01875	COG1686	Belongs to the peptidase S11 family
HRD68_01885	COG0626	cystathionine gamma-synthase activity
HRD68_01900	COG2011	ABC-type metal ion transport system permease component
HRD68_01925	COG0625	glutathione transferase activity
HRD68_01930	COG4771	TonB-dependent receptor
HRD68_01935	COG0833	amino acid
HRD68_01940	COG0583	DNA-binding transcription factor activity
HRD68_01950	COG2855	membrane
HRD68_01955	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HRD68_01960	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HRD68_01960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRD68_01960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRD68_01965	COG1105	Belongs to the carbohydrate kinase PfkB family
HRD68_01990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRD68_02000	COG0246	Mannitol dehydrogenase
HRD68_02005	COG2186	Transcriptional regulator
HRD68_02015	COG0523	cobalamin synthesis protein
HRD68_02020	COG0671	phosphoesterase, PA-phosphatase related
HRD68_02025	COG0791	NLP P60 protein
HRD68_02030	COG2200	EAL domain
HRD68_02035	COG4166	transmembrane transport
HRD68_02040	COG4174	ABC transporter (Permease)
HRD68_02045	COG4239	(ABC) transporter, permease
HRD68_02050	COG4172	Belongs to the ABC transporter superfamily
HRD68_02060	COG2814	Major facilitator Superfamily
HRD68_02065	COG1187	pseudouridine synthase activity
HRD68_02070	COG1061	Type III restriction enzyme res subunit
HRD68_02080	COG3081	Nucleoid-associated protein
HRD68_02085	COG3082	Protein of unknown function (DUF1414)
HRD68_02110	COG0657	acetylesterase activity
HRD68_02110	COG2755	lipolytic protein G-D-S-L family
HRD68_02115	COG3539	Fimbrial protein
HRD68_02120	COG3539	Fimbrial protein
HRD68_02125	COG3539	Fimbrial protein
HRD68_02135	COG3121	Chaperone
HRD68_02140	COG3539	Fimbrial protein
HRD68_02145	COG2723	6-phospho-beta-galactosidase activity
HRD68_02150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_02150	COG2190	(PTS) system
HRD68_02150	COG1263	PTS System
HRD68_02155	COG1737	Transcriptional regulator
HRD68_02175	COG3121	Chaperone
HRD68_02210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HRD68_02235	COG1132	(ABC) transporter
HRD68_02250	COG2223	nitrite transmembrane transporter activity
HRD68_02255	COG0642	Histidine kinase
HRD68_02255	COG2198	Histidine kinase
HRD68_02265	COG2205	protein histidine kinase activity
HRD68_02265	COG0784	Response regulator, receiver
HRD68_02280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD68_02290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD68_02295	COG4574	serine-type endopeptidase inhibitor activity
HRD68_02305	COG0814	amino acid
HRD68_02325	COG1441	menaquinone biosynthetic process
HRD68_02330	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HRD68_02340	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HRD68_02345	COG1169	isochorismate synthase
HRD68_02355	COG4575	ribosome binding
HRD68_02360	COG0129	dihydroxy-acid dehydratase activity
HRD68_02365	COG4702	Belongs to the UPF0303 family
HRD68_02375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRD68_02380	COG1609	Transcriptional regulator
HRD68_02385	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_02390	COG3265	gluconokinase activity
HRD68_02395	COG2731	YhcH YjgK YiaL family protein
HRD68_02415	COG1007	ATP synthesis coupled electron transport
HRD68_02420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_02425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRD68_02430	COG0713	ATP synthesis coupled electron transport
HRD68_02435	COG0839	Belongs to the complex I subunit 6 family
HRD68_02440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_02445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRD68_02450	COG1034	ATP synthesis coupled electron transport
HRD68_02465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_02465	COG0649	NAD binding
HRD68_02470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_02475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_02480	COG0583	DNA-binding transcription factor activity
HRD68_02485	COG0436	Aminotransferase
HRD68_02490	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HRD68_02495	COG0471	metal ion transport
HRD68_02495	COG0490	domain, Protein
HRD68_02505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD68_02510	COG3013	Belongs to the UPF0304 family
HRD68_02515	COG3092	negative regulation of chromosome organization
HRD68_02525	COG0280	phosphate acetyltransferase
HRD68_02525	COG0857	belongs to the CobB CobQ family
HRD68_02530	COG1609	Transcriptional regulator
HRD68_02535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_02545	COG3037	sugar-specific permease SgaT UlaA
HRD68_02555	COG4149	molybdate abc transporter
HRD68_02595	COG3778	Protein conserved in bacteria
HRD68_02600	COG3299	homolog of phage Mu protein gp47
HRD68_02645	COG4386	tail sheath protein
HRD68_02695	COG1802	Transcriptional regulator
HRD68_02695	COG4626	Terminase
HRD68_02740	COG0305	Participates in initiation and elongation during chromosome replication
HRD68_02745	COG1484	DNA-dependent DNA replication
HRD68_02765	COG1396	sequence-specific DNA binding
HRD68_02880	COG0582	viral genome integration into host DNA
HRD68_02885	COG0725	ABC transporter, periplasmic molybdate-binding protein
HRD68_02895	COG3585	molybdate ion transport
HRD68_02895	COG2005	Transcriptional regulator
HRD68_02900	COG1119	ATPase activity
HRD68_02910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRD68_02915	COG1085	galactose-1-phosphate uridylyltransferase
HRD68_02920	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HRD68_02925	COG2017	converts alpha-aldose to the beta-anomer
HRD68_02935	COG0588	phosphoglycerate mutase activity
HRD68_02940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRD68_02945	COG1230	cation diffusion facilitator family transporter
HRD68_02955	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HRD68_02985	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HRD68_02990	COG2885	chlorophyll binding
HRD68_02995	COG0823	Involved in the tonB-independent uptake of proteins
HRD68_03000	COG3064	Membrane
HRD68_03000	COG3064	Membrane
HRD68_03005	COG0848	biopolymer transport protein
HRD68_03010	COG0811	peptide transport
HRD68_03015	COG0824	Thioesterase
HRD68_03020	COG3790	cyd operon protein YbgE
HRD68_03025	COG4890	Cyd operon protein YbgT
HRD68_03030	COG1294	oxidase, subunit
HRD68_03035	COG1271	oxidase subunit
HRD68_03040	COG0737	Belongs to the 5'-nucleotidase family
HRD68_03045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HRD68_03055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD68_03060	COG0567	Dehydrogenase, E1 component
HRD68_03065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRD68_03070	COG1053	succinate dehydrogenase
HRD68_03075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HRD68_03105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HRD68_03110	COG1984	allophanate hydrolase subunit 2
HRD68_03115	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HRD68_03120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRD68_03125	COG5212	phosphodiesterase
HRD68_03135	COG3272	Protein of unknown function (DUF1722)
HRD68_03150	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HRD68_03155	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HRD68_03160	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HRD68_03165	COG2205	protein histidine kinase activity
HRD68_03170	COG0745	RESPONSE REGULATOR receiver
HRD68_03180	COG0033	Phosphoglucomutase
HRD68_03185	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HRD68_03190	COG0596	Alpha beta hydrolase
HRD68_03200	COG0840	transmembrane signaling receptor activity
HRD68_03210	COG0735	belongs to the Fur family
HRD68_03235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRD68_03240	COG2190	(PTS) system
HRD68_03240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_03240	COG1263	PTS System
HRD68_03250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRD68_03255	COG1940	carbohydrate kinase activity
HRD68_03255	COG1846	Transcriptional regulator
HRD68_03260	COG0647	UMP catabolic process
HRD68_03265	COG0367	asparagine synthase
HRD68_03300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD68_03305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRD68_03310	COG1702	phosphate starvation-inducible protein PhoH
HRD68_03315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRD68_03320	COG4535	Mg2 and Co2 transporter CorC
HRD68_03325	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRD68_03335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_03340	COG0765	amino acid transport
HRD68_03345	COG0765	amino acid transport
HRD68_03350	COG1126	abc transporter atp-binding protein
HRD68_03355	COG2888	peptidyl-tyrosine sulfation
HRD68_03365	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HRD68_03370	COG1466	dna polymerase III delta subunit
HRD68_03375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRD68_03380	COG0799	negative regulation of ribosome biogenesis
HRD68_03390	COG0768	penicillin binding
HRD68_03395	COG0772	Belongs to the SEDS family
HRD68_03400	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRD68_03405	COG1686	Belongs to the peptidase S11 family
HRD68_03410	COG2921	Belongs to the UPF0250 family
HRD68_03415	COG0321	lipoyl(octanoyl) transferase activity
HRD68_03420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRD68_03425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD68_03430	COG3706	GGDEF domain
HRD68_03445	COG1278	Cold shock
HRD68_03450	COG2197	response regulator
HRD68_03460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRD68_03475	COG5265	(ABC) transporter
HRD68_03485	COG2850	peptidyl-arginine hydroxylation
HRD68_03490	COG2188	Transcriptional regulator
HRD68_03500	COG0471	metal ion transport
HRD68_03510	COG2979	Protein of unknown function (DUF533)
HRD68_03550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD68_03555	COG2313	pseudouridylate synthase activity
HRD68_03560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD68_03585	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HRD68_03605	COG3064	Membrane
HRD68_03625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRD68_03630	COG2501	S4 domain
HRD68_03650	COG3539	Fimbrial protein
HRD68_03660	COG3121	Chaperone
HRD68_03665	COG3188	usher protein
HRD68_03685	COG0215	cysteine-tRNA ligase activity
HRD68_03690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRD68_03695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD68_03700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRD68_03705	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HRD68_03710	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HRD68_03715	COG4181	ATPase activity
HRD68_03720	COG2755	lipolytic protein G-D-S-L family
HRD68_03725	COG0300	oxidoreductase activity
HRD68_03730	COG3118	belongs to the thioredoxin family
HRD68_03735	COG0330	HflC and HflK could
HRD68_03740	COG1585	Membrane protein implicated in regulation of membrane protease activity
HRD68_03750	COG2217	Heavy metal translocating P-type atpase
HRD68_03755	COG3735	TraB family
HRD68_03760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRD68_03765	COG0737	Belongs to the 5'-nucleotidase family
HRD68_03770	COG2223	nitrite transmembrane transporter activity
HRD68_03775	COG4651	solute:proton antiporter activity
HRD68_03775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRD68_03780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD68_03785	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HRD68_03800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD68_03825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRD68_03830	COG0563	adenylate kinase activity
HRD68_03835	COG0326	Molecular chaperone. Has ATPase activity
HRD68_03840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRD68_03855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRD68_03860	COG2832	Protein of unknown function (DUF454)
HRD68_03875	COG1196	nuclear chromosome segregation
HRD68_03875	COG3264	Mechanosensitive ion channel
HRD68_03880	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HRD68_03885	COG1309	transcriptional regulator
HRD68_03890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_03895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD68_03905	COG3457	Alanine racemase
HRD68_03910	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HRD68_03915	COG0254	rRNA binding
HRD68_03920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRD68_03925	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRD68_03930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD68_03935	COG1121	(ABC) transporter
HRD68_03970	COG3695	enzyme binding
HRD68_03975	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HRD68_03980	COG1946	Acyl-CoA thioesterase
HRD68_03985	COG0004	ammonium transporteR
HRD68_03990	COG0347	Belongs to the P(II) protein family
HRD68_03995	COG1132	(ABC) transporter
HRD68_04000	COG1132	(ABC) transporter
HRD68_04005	COG1522	sequence-specific DNA binding
HRD68_04015	COG0561	phosphatase activity
HRD68_04020	COG4533	DNA binding
HRD68_04025	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRD68_04030	COG0824	Thioesterase
HRD68_04035	COG1555	photosystem II stabilization
HRD68_04040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRD68_04045	COG0776	regulation of translation
HRD68_04050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRD68_04055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRD68_04060	COG0740	serine-type endopeptidase activity
HRD68_04065	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRD68_04070	COG0271	Belongs to the BolA IbaG family
HRD68_04075	COG3056	Lipoprotein
HRD68_04080	COG2223	nitrite transmembrane transporter activity
HRD68_04090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HRD68_04095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRD68_04100	COG1845	cytochrome c oxidase, subunit III
HRD68_04105	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HRD68_04110	COG0109	protoheme IX farnesyltransferase activity
HRD68_04115	COG2814	Major facilitator Superfamily
HRD68_04120	COG1666	GTP binding
HRD68_04125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HRD68_04130	COG0693	protein deglycase activity
HRD68_04135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRD68_04135	COG0301	tRNA thio-modification
HRD68_04145	COG0142	geranyltranstransferase activity
HRD68_04150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRD68_04155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HRD68_04160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HRD68_04175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRD68_04175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRD68_04180	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRD68_04190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRD68_04195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRD68_04200	COG1862	Preprotein translocase
HRD68_04205	COG0343	queuine tRNA-ribosyltransferase activity
HRD68_04215	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HRD68_04220	COG0450	alkyl hydroperoxide reductase
HRD68_04235	COG0366	Alpha amylase catalytic
HRD68_04255	COG5002	protein histidine kinase activity
HRD68_04260	COG0745	RESPONSE REGULATOR receiver
HRD68_04265	COG0420	3'-5' exonuclease activity
HRD68_04270	COG0419	ATPase involved in DNA repair
HRD68_04275	COG1940	carbohydrate kinase activity
HRD68_04280	COG2974	May be involved in recombination
HRD68_04285	COG3123	guanosine phosphorylase activity
HRD68_04290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRD68_04305	COG2226	methyltransferase
HRD68_04320	COG3459	Glycosyltransferase 36 associated
HRD68_04330	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRD68_04335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRD68_04355	COG2195	Cleaves the N-terminal amino acid of tripeptides
HRD68_04360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRD68_04370	COG2991	Protein conserved in bacteria
HRD68_04375	COG1477	protein flavinylation
HRD68_04380	COG2871	sodium ion transport
HRD68_04385	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD68_04390	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD68_04395	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD68_04400	COG1805	sodium ion transport
HRD68_04405	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD68_04410	COG3034	peptidoglycan biosynthetic process
HRD68_04415	COG0121	glutamine amidotransferase
HRD68_04425	COG1960	acyl-CoA dehydrogenase activity
HRD68_04430	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
HRD68_04445	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HRD68_04455	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HRD68_04465	COG0235	Class ii aldolase
HRD68_04470	COG0436	Aminotransferase
HRD68_04480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HRD68_04485	COG2814	Major facilitator Superfamily
HRD68_04490	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HRD68_04500	COG1846	Transcriptional regulator
HRD68_04510	COG1566	PFAM secretion protein HlyD family protein
HRD68_04515	COG2814	Major facilitator Superfamily
HRD68_04520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD68_04525	COG3118	belongs to the thioredoxin family
HRD68_04535	COG0045	succinate-CoA ligase (ADP-forming) activity
HRD68_04535	COG1042	CoA-binding domain protein
HRD68_04535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD68_04540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRD68_04570	COG0542	response to heat
HRD68_04580	COG0564	pseudouridine synthase activity
HRD68_04585	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD68_04590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRD68_04595	COG1605	Chorismate mutase
HRD68_04595	COG0077	Prephenate dehydratase
HRD68_04600	COG0287	Prephenate dehydrogenase
HRD68_04600	COG1605	Chorismate mutase
HRD68_04605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRD68_04610	COG3279	Response regulator of the LytR AlgR family
HRD68_04615	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HRD68_04620	COG3137	Salt-induced outer membrane protein
HRD68_04625	COG0335	large ribosomal subunit rRNA binding
HRD68_04635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRD68_04645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HRD68_04650	COG4137	Cytochrome C assembly protein
HRD68_04655	COG4536	flavin adenine dinucleotide binding
HRD68_04660	COG1854	S-ribosylhomocysteine lyase activity
HRD68_04665	COG2918	glutathione biosynthetic process
HRD68_04670	COG1238	metal cluster binding
HRD68_04675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD68_04700	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HRD68_04705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRD68_04710	COG2137	regulation of response to DNA damage stimulus
HRD68_04715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRD68_04740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD68_04745	COG3958	Transketolase
HRD68_04750	COG3959	Transketolase, thiamine diphosphate binding domain
HRD68_04755	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_04760	COG1129	ABC transporter
HRD68_04785	COG3381	protein complex oligomerization
HRD68_04790	COG3302	dmso reductase anchor subunit
HRD68_04795	COG0437	4 iron, 4 sulfur cluster binding
HRD68_04800	COG0243	molybdopterin cofactor binding
HRD68_04805	COG1454	alcohol dehydrogenase
HRD68_04810	COG0235	Class ii aldolase
HRD68_04815	COG0738	Major facilitator superfamily
HRD68_04825	COG1070	Carbohydrate kinase
HRD68_04835	COG1349	DNA-binding transcription factor activity
HRD68_04845	COG1349	DNA-binding transcription factor activity
HRD68_04855	COG1129	ABC transporter
HRD68_04860	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_04870	COG3623	hexulose-6-phosphate isomerase
HRD68_04875	COG1070	Carbohydrate kinase
HRD68_04880	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD68_04880	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD68_04895	COG4177	L-phenylalanine transmembrane transporter activity
HRD68_04900	COG1137	ATPase activity
HRD68_04905	COG0410	ABC transporter
HRD68_04960	COG0640	Transcriptional regulator
HRD68_04965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRD68_04980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD68_04985	COG1126	abc transporter atp-binding protein
HRD68_04990	COG0765	amino acid transport
HRD68_04995	COG0765	amino acid transport
HRD68_05005	COG3048	D-serine ammonia-lyase activity
HRD68_05010	COG2610	gluconate transmembrane transporter activity
HRD68_05015	COG0583	DNA-binding transcription factor activity
HRD68_05020	COG4608	Belongs to the ABC transporter superfamily
HRD68_05025	COG0444	Belongs to the ABC transporter superfamily
HRD68_05035	COG0601	transmembrane transport
HRD68_05040	COG0747	negative chemotaxis
HRD68_05045	COG4948	Mandelate Racemase Muconate Lactonizing
HRD68_05050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD68_05065	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_05085	COG1538	Outer membrane efflux protein
HRD68_05090	COG1136	(ABC) transporter
HRD68_05090	COG0577	efflux transmembrane transporter activity
HRD68_05095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_05125	COG3539	Fimbrial protein
HRD68_05130	COG3539	Fimbrial protein
HRD68_05145	COG3121	Chaperone
HRD68_05150	COG3188	usher protein
HRD68_05175	COG3876	Protein conserved in bacteria
HRD68_05185	COG1472	Belongs to the glycosyl hydrolase 3 family
HRD68_05195	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HRD68_05200	COG1263	PTS System
HRD68_05200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_05215	COG3121	Chaperone
HRD68_05220	COG3121	Chaperone
HRD68_05230	COG3121	Chaperone
HRD68_05245	COG0626	cystathionine gamma-synthase activity
HRD68_05255	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HRD68_05260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRD68_05265	COG4942	peptidase
HRD68_05265	COG1388	LysM domain
HRD68_05270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRD68_05275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRD68_05280	COG0585	pseudouridine synthase activity
HRD68_05285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRD68_05295	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HRD68_05305	COG0765	amino acid transport
HRD68_05320	COG0529	Catalyzes the synthesis of activated sulfate
HRD68_05325	COG2895	sulfate adenylyltransferase (ATP) activity
HRD68_05330	COG0175	sulfate reduction
HRD68_05335	COG1648	precorrin-2 dehydrogenase activity
HRD68_05335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRD68_05340	COG2234	aminopeptidase activity
HRD68_05345	COG0175	sulfate reduction
HRD68_05350	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD68_05355	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HRD68_05360	COG0720	synthase
HRD68_05365	COG0602	queuosine metabolic process
HRD68_05380	COG0504	CTP synthase activity
HRD68_05385	COG3956	TIGRFAM MazG family protein
HRD68_05390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD68_05395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRD68_05405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD68_05410	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRD68_05415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRD68_05425	COG2860	membrane
HRD68_05435	COG0316	Belongs to the HesB IscA family
HRD68_05445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRD68_05450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD68_05455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRD68_05460	COG1120	ATPase activity
HRD68_05465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD68_05470	COG1643	Atp-dependent helicase
HRD68_05475	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HRD68_05495	COG0617	tRNA 3'-terminal CCA addition
HRD68_05500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRD68_05505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRD68_05510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRD68_05515	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HRD68_05520	COG0726	polysaccharide deacetylase
HRD68_05525	COG0842	Transport permease protein
HRD68_05530	COG1131	(ABC) transporter
HRD68_05535	COG0288	reversible hydration of carbon dioxide
HRD68_05540	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HRD68_05550	COG2132	Multicopper oxidase
HRD68_05560	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HRD68_05575	COG3112	Uncharacterised protein family (UPF0231)
HRD68_05595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD68_05600	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD68_05605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HRD68_05610	COG2186	Transcriptional regulator
HRD68_05615	COG1113	amino acid transport
HRD68_05625	COG3725	Membrane protein required for beta-lactamase induction
HRD68_05630	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRD68_05640	COG4969	Belongs to the N-Me-Phe pilin family
HRD68_05645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRD68_05650	COG1459	type II secretion system
HRD68_05655	COG0516	GMP reductase activity
HRD68_05670	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HRD68_05675	COG0494	nUDIX hydrolase
HRD68_05680	COG0653	protein targeting
HRD68_05700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HRD68_05705	COG0849	cell division
HRD68_05710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HRD68_05720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRD68_05725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRD68_05730	COG0772	Belongs to the SEDS family
HRD68_05740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRD68_05745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRD68_05750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRD68_05755	COG0768	penicillin binding
HRD68_05760	COG3116	cell division
HRD68_05765	COG0275	rRNA processing
HRD68_05790	COG0028	Belongs to the TPP enzyme family
HRD68_05795	COG1022	Amp-dependent synthetase and ligase
HRD68_05815	COG0473	3-isopropylmalate dehydrogenase activity
HRD68_05820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRD68_05835	COG3033	Beta-eliminating lyase
HRD68_05840	COG0814	amino acid
HRD68_05845	COG2814	Major facilitator Superfamily
HRD68_05850	COG1882	Formate acetyltransferase
HRD68_05855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRD68_05860	COG4533	DNA binding
HRD68_05865	COG4143	(ABC) transporter
HRD68_05870	COG1178	ABC-type Fe3 transport system permease component
HRD68_05875	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HRD68_05880	COG0586	Pfam SNARE associated Golgi protein
HRD68_05885	COG0417	DNA replication proofreading
HRD68_05895	COG2375	cellular response to nickel ion
HRD68_05930	COG0564	pseudouridine synthase activity
HRD68_05940	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HRD68_05945	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD68_05960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRD68_05965	COG2967	ApaG domain
HRD68_05970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRD68_05975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HRD68_05985	COG2966	Psort location CytoplasmicMembrane, score
HRD68_05990	COG1280	lysine exporter protein (LysE YggA)
HRD68_05995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRD68_06010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRD68_06015	COG1047	Peptidyl-prolyl cis-trans
HRD68_06025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRD68_06030	COG0196	riboflavin kinase activity
HRD68_06050	COG0583	DNA-binding transcription factor activity
HRD68_06055	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRD68_06065	COG0484	heat shock protein binding
HRD68_06075	COG1584	GPR1 FUN34 yaaH family protein
HRD68_06090	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRD68_06095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRD68_06100	COG3022	response to hydroperoxide
HRD68_06110	COG0083	homoserine kinase activity
HRD68_06125	COG0745	RESPONSE REGULATOR receiver
HRD68_06130	COG3045	CreA protein
HRD68_06135	COG2207	Transcriptional regulator
HRD68_06135	COG3708	Transcriptional regulator
HRD68_06140	COG0406	alpha-ribazole phosphatase activity
HRD68_06145	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HRD68_06150	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HRD68_06155	COG0741	lytic transglycosylase activity
HRD68_06160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HRD68_06170	COG2199	diguanylate cyclase activity
HRD68_06175	COG2885	chlorophyll binding
HRD68_06180	COG0488	(ABC) transporter
HRD68_06215	COG1454	alcohol dehydrogenase
HRD68_06230	COG0604	alcohol dehydrogenase
HRD68_06245	COG0560	Phosphoserine phosphatase
HRD68_06250	COG3726	membrane protein affecting hemolysin expression
HRD68_06255	COG2026	Addiction module toxin, RelE StbE family
HRD68_06270	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HRD68_06285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD68_06290	COG0084	hydrolase, TatD family'
HRD68_06295	COG4667	esterase of the alpha-beta hydrolase superfamily
HRD68_06305	COG2823	Periplasmic or secreted lipoprotein
HRD68_06310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HRD68_06320	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HRD68_06325	COG2813	Specifically methylates the guanine in position
HRD68_06330	COG0667	Aldo Keto reductase
HRD68_06360	COG3706	GGDEF domain
HRD68_06365	COG3284	Transcriptional regulator
HRD68_06375	COG0738	Major facilitator superfamily
HRD68_06390	COG2192	nodulation
HRD68_06400	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HRD68_06400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD68_06400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_06405	COG1461	Dihydroxyacetone kinase
HRD68_06410	COG2376	Dihydroxyacetone kinase
HRD68_06420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD68_06425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_06430	COG2235	arginine
HRD68_06445	COG0859	PFAM glycosyl transferase family 9
HRD68_06450	COG1070	Carbohydrate kinase
HRD68_06455	COG2390	Transcriptional regulator
HRD68_06460	COG1129	ABC transporter
HRD68_06465	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_06470	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_06480	COG1830	Aldolase
HRD68_06495	COG3550	peptidyl-serine autophosphorylation
HRD68_06500	COG1396	sequence-specific DNA binding
HRD68_06515	COG2771	luxR family
HRD68_06595	COG1401	restriction endodeoxyribonuclease activity
HRD68_06640	COG0582	viral genome integration into host DNA
HRD68_06650	COG0795	lipopolysaccharide-transporting ATPase activity
HRD68_06655	COG0795	lipopolysaccharide-transporting ATPase activity
HRD68_06660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRD68_06665	COG2927	DNA polymerase III (CHI subunit)
HRD68_06680	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HRD68_06690	COG2731	YhcH YjgK YiaL family protein
HRD68_06700	COG0601	transmembrane transport
HRD68_06710	COG0444	Belongs to the ABC transporter superfamily
HRD68_06715	COG4608	Belongs to the ABC transporter superfamily
HRD68_06735	COG0602	queuosine metabolic process
HRD68_06750	COG2188	Transcriptional regulator
HRD68_06755	COG3624	Phosphonate C-P lyase system protein PhnG
HRD68_06760	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HRD68_06765	COG3626	phosphonate metabolism
HRD68_06770	COG3627	carbon phosphorus lyase activity
HRD68_06775	COG4107	phosphonate C-P lyase system protein PhnK
HRD68_06780	COG4778	phosphonate C-P lyase system protein PhnL
HRD68_06785	COG3454	Phosphonate metabolism
HRD68_06790	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HRD68_06795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HRD68_06800	COG0702	epimerase
HRD68_06815	COG3842	ATPase activity
HRD68_06820	COG0395	ABC-type sugar transport system, permease component
HRD68_06825	COG1175	transmembrane transport
HRD68_06830	COG1653	transport
HRD68_06850	COG1982	Orn Lys Arg decarboxylase major
HRD68_06855	COG0531	amino acid
HRD68_06865	COG3153	acetyltransferase
HRD68_06870	COG3154	lipid carrier protein
HRD68_06875	COG0826	peptidase U32
HRD68_06880	COG0826	peptidase U32
HRD68_06885	COG3681	Belongs to the UPF0597 family
HRD68_06890	COG0814	amino acid
HRD68_06895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD68_06900	COG0513	Belongs to the DEAD box helicase family
HRD68_06915	COG1185	polyribonucleotide nucleotidyltransferase activity
HRD68_06925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRD68_06930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRD68_06940	COG0195	Participates in both transcription termination and antitermination
HRD68_06960	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRD68_06970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRD68_06980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HRD68_06985	COG1534	Rna-binding protein
HRD68_06995	COG2027	D-alanyl-D-alanine carboxypeptidase
HRD68_07000	COG0745	RESPONSE REGULATOR receiver
HRD68_07005	COG0642	Histidine kinase
HRD68_07010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRD68_07015	COG0697	spore germination
HRD68_07020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRD68_07030	COG0142	geranyltranstransferase activity
HRD68_07040	COG3423	Transcriptional regulator
HRD68_07060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRD68_07075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRD68_07080	COG2105	PFAM AIG2 family protein
HRD68_07085	COG2911	Protein conserved in bacteria
HRD68_07095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRD68_07100	COG1253	flavin adenine dinucleotide binding
HRD68_07110	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HRD68_07115	COG1218	3'(2'),5'-bisphosphate nucleotidase
HRD68_07120	COG0737	Belongs to the 5'-nucleotidase family
HRD68_07130	COG0545	Peptidyl-prolyl cis-trans isomerase
HRD68_07135	COG3061	Opacity-associated protein A
HRD68_07145	COG0359	binds to the 23S rRNA
HRD68_07150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRD68_07160	COG0360	Binds together with S18 to 16S ribosomal RNA
HRD68_07170	COG1073	alpha beta
HRD68_07175	COG3650	response to hydrogen peroxide
HRD68_07180	COG1960	acyl-CoA dehydrogenase activity
HRD68_07185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD68_07190	COG0557	exoribonuclease II activity
HRD68_07195	COG1959	2 iron, 2 sulfur cluster binding
HRD68_07205	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HRD68_07210	COG0330	HflC and HflK could
HRD68_07215	COG0330	HflC and HflK could
HRD68_07220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRD68_07230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRD68_07245	COG0802	atpase or kinase
HRD68_07250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRD68_07250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRD68_07255	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRD68_07275	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HRD68_07280	COG1162	GTPase activity
HRD68_07285	COG0688	phosphatidylethanolamine metabolic process
HRD68_07290	COG3264	Mechanosensitive ion channel
HRD68_07290	COG1511	domain protein
HRD68_07300	COG1053	succinate dehydrogenase
HRD68_07305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRD68_07310	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HRD68_07315	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HRD68_07335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRD68_07350	COG0459	protein refolding
HRD68_07355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRD68_07370	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HRD68_07380	COG4232	protein-disulfide reductase activity
HRD68_07385	COG3383	formate dehydrogenase (NAD+) activity
HRD68_07390	COG0493	'glutamate synthase
HRD68_07390	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_07395	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_07395	COG0493	'glutamate synthase
HRD68_07400	COG2271	Major facilitator Superfamily
HRD68_07405	COG1929	Belongs to the glycerate kinase type-1 family
HRD68_07410	COG2721	sulfolactate sulfo-lyase activity
HRD68_07415	COG3835	regulator
HRD68_07420	COG1929	Belongs to the glycerate kinase type-1 family
HRD68_07425	COG2084	Dehydrogenase
HRD68_07435	COG1309	transcriptional regulator
HRD68_07445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD68_07445	COG0543	2 iron, 2 sulfur cluster binding
HRD68_07450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRD68_07480	COG0463	Glycosyl transferase, family 2
HRD68_07495	COG0489	protein tyrosine kinase activity
HRD68_07505	COG1215	transferase activity, transferring glycosyl groups
HRD68_07510	COG0457	Tetratricopeptide repeat
HRD68_07520	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HRD68_07530	COG3721	Heme iron utilization protein
HRD68_07535	COG0702	epimerase
HRD68_07545	COG4771	TonB-dependent receptor
HRD68_07550	COG3720	iron ion transport
HRD68_07555	COG4558	Periplasmic binding protein
HRD68_07560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD68_07565	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HRD68_07570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD68_07580	COG4774	siderophore transport
HRD68_07585	COG3264	Mechanosensitive ion channel
HRD68_07585	COG1196	nuclear chromosome segregation
HRD68_07735	COG2197	response regulator
HRD68_07740	COG2205	protein histidine kinase activity
HRD68_07780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRD68_07825	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HRD68_07835	COG3397	chitin binding
HRD68_07845	COG0612	Peptidase, M16
HRD68_07850	COG4178	(ABC) transporter
HRD68_07855	COG4771	TonB-dependent receptor
HRD68_07860	COG3712	iron ion homeostasis
HRD68_07865	COG1595	DNA-templated transcription, initiation
HRD68_07880	COG3093	addiction module antidote protein HigA
HRD68_07885	COG0425	Belongs to the sulfur carrier protein TusA family
HRD68_07890	COG2391	methyltransferase activity
HRD68_08055	COG1301	dicarboxylic acid transport
HRD68_08060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRD68_08065	COG3162	membrane
HRD68_08070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRD68_08115	COG0151	Belongs to the GarS family
HRD68_08135	COG1515	deoxyribonuclease V activity
HRD68_08145	COG2816	NAD+ diphosphatase activity
HRD68_08150	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HRD68_08165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRD68_08170	COG2104	thiamine diphosphate biosynthetic process
HRD68_08185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRD68_08190	COG0085	RNA polymerase activity
HRD68_08195	COG0222	ribosome binding
HRD68_08200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRD68_08210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRD68_08215	COG0250	Participates in transcription elongation, termination and antitermination
HRD68_08255	COG1072	(Pantothenic acid kinase))
HRD68_08260	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HRD68_08260	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HRD68_08295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRD68_08300	COG1739	Uncharacterized protein family UPF0029
HRD68_08310	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD68_08310	COG1024	Enoyl-CoA hydratase
HRD68_08315	COG0183	Belongs to the thiolase family
HRD68_08325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HRD68_08345	COG0805	protein transport
HRD68_08355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD68_08360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRD68_08370	COG2226	methyltransferase
HRD68_08375	COG1322	Protein conserved in bacteria
HRD68_08380	COG0586	Pfam SNARE associated Golgi protein
HRD68_08385	COG1966	Carbon starvation protein
HRD68_08400	COG0412	Dienelactone hydrolase
HRD68_08405	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HRD68_08410	COG0583	DNA-binding transcription factor activity
HRD68_08415	COG0697	spore germination
HRD68_08420	COG0679	Auxin Efflux Carrier
HRD68_08425	COG0584	glycerophosphoryl diester phosphodiesterase
HRD68_08430	COG3842	ATPase activity
HRD68_08435	COG0395	ABC-type sugar transport system, permease component
HRD68_08440	COG1175	transmembrane transport
HRD68_08445	COG1653	transport
HRD68_08480	COG0410	ABC transporter
HRD68_08490	COG4177	L-phenylalanine transmembrane transporter activity
HRD68_08500	COG0683	leucine binding
HRD68_08505	COG0456	acetyltransferase
HRD68_08515	COG2177	Part of the ABC transporter FtsEX involved in
HRD68_08520	COG2884	Cell division ATP-binding protein ftsE
HRD68_08525	COG0552	protein localization to endoplasmic reticulum
HRD68_08525	COG0552	protein localization to endoplasmic reticulum
HRD68_08530	COG0742	ribosomal rna small subunit methyltransferase
HRD68_08535	COG3776	membrane
HRD68_08550	COG3714	YhhN family
HRD68_08560	COG0425	Belongs to the sulfur carrier protein TusA family
HRD68_08565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HRD68_08575	COG0247	lactate metabolic process
HRD68_08585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRD68_08590	COG2271	Major facilitator Superfamily
HRD68_08595	COG0584	glycerophosphoryl diester phosphodiesterase
HRD68_08600	COG0561	phosphatase activity
HRD68_08605	COG2267	carboxylic ester hydrolase activity
HRD68_08610	COG1280	lysine exporter protein (LysE YggA)
HRD68_08615	COG1280	lysine exporter protein (LysE YggA)
HRD68_08620	COG0514	ATP-dependent DNA helicase (RecQ)
HRD68_08625	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HRD68_08630	COG2050	protein possibly involved in aromatic compounds catabolism
HRD68_08645	COG5564	TIM-barrel signal transduction protein
HRD68_08660	COG0210	DNA helicase
HRD68_08665	COG1011	Hydrolase
HRD68_08670	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HRD68_08675	COG3159	Protein conserved in bacteria
HRD68_08680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRD68_08685	COG5567	small periplasmic lipoprotein
HRD68_08695	COG3072	Adenylate cyclase
HRD68_08700	COG0181	hydroxymethylbilane synthase activity
HRD68_08705	COG1587	Uroporphyrinogen-III synthase
HRD68_08710	COG2959	enzyme of heme biosynthesis
HRD68_08715	COG3071	HemY protein
HRD68_08740	COG1113	amino acid transport
HRD68_08755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD68_08760	COG2244	polysaccharide biosynthetic process
HRD68_08765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD68_08770	COG0456	acetyltransferase
HRD68_08775	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HRD68_08780	COG1088	dTDP-glucose 4,6-dehydratase activity
HRD68_08785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HRD68_08790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HRD68_08795	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HRD68_08800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRD68_08805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HRD68_08810	COG3118	belongs to the thioredoxin family
HRD68_08820	COG0248	Ppx GppA phosphatase
HRD68_08835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRD68_08845	COG3121	Chaperone
HRD68_08860	COG3121	Chaperone
HRD68_08865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRD68_08870	COG0583	DNA-binding transcription factor activity
HRD68_08880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRD68_08885	COG0129	dihydroxy-acid dehydratase activity
HRD68_08890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRD68_08895	COG3978	acetolactate synthase activity
HRD68_08915	COG3085	chromosome segregation
HRD68_08920	COG0583	DNA-binding transcription factor activity
HRD68_08925	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_08930	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_08935	COG1129	ABC transporter
HRD68_08940	COG1879	ABC-type sugar transport system periplasmic component
HRD68_08980	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRD68_08990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRD68_09005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD68_09015	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRD68_09015	COG0678	peroxiredoxin activity
HRD68_09020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD68_09045	COG1629	transport
HRD68_09050	COG0165	Argininosuccinate lyase
HRD68_09070	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HRD68_09080	COG2814	Major facilitator Superfamily
HRD68_09085	COG1494	fructose-1,6-bisphosphatase
HRD68_09090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD68_09095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRD68_09100	COG3074	FtsZ-dependent cytokinesis
HRD68_09105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRD68_09110	COG1575	Belongs to the MenA family. Type 1 subfamily
HRD68_09115	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HRD68_09120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HRD68_09125	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRD68_09130	COG1609	Transcriptional regulator
HRD68_09135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRD68_09140	COG0254	rRNA binding
HRD68_09145	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HRD68_09150	COG0626	cystathionine gamma-synthase activity
HRD68_09155	COG0527	aspartate kinase activity
HRD68_09155	COG0460	homoserine dehydrogenase
HRD68_09165	COG3152	Membrane
HRD68_09185	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HRD68_09195	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRD68_09200	COG3678	ATP-independent chaperone mediated protein folding
HRD68_09205	COG0745	RESPONSE REGULATOR receiver
HRD68_09210	COG2205	protein histidine kinase activity
HRD68_09215	COG2169	Transcriptional regulator
HRD68_09215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRD68_09220	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HRD68_09225	COG1045	serine acetyltransferase
HRD68_09230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRD68_09235	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HRD68_09240	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRD68_09245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRD68_09250	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HRD68_09255	COG4942	peptidase
HRD68_09260	COG2861	carbohydrate metabolic process
HRD68_09270	COG0156	8-amino-7-oxononanoate synthase activity
HRD68_09275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD68_09280	COG0859	PFAM glycosyl transferase family 9
HRD68_09285	COG0859	PFAM glycosyl transferase family 9
HRD68_09290	COG1519	Transferase
HRD68_09305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRD68_09310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRD68_09315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRD68_09325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HRD68_09330	COG0756	dUTP diphosphatase activity
HRD68_09335	COG1309	transcriptional regulator
HRD68_09345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD68_09355	COG2199	diguanylate cyclase activity
HRD68_09355	COG2200	EAL domain
HRD68_09360	COG4608	Belongs to the ABC transporter superfamily
HRD68_09365	COG0444	Belongs to the ABC transporter superfamily
HRD68_09370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD68_09375	COG0601	transmembrane transport
HRD68_09380	COG0747	negative chemotaxis
HRD68_09390	COG2831	hemolysin activation secretion protein
HRD68_09400	COG2271	Major facilitator Superfamily
HRD68_09405	COG3851	Histidine kinase
HRD68_09410	COG2197	response regulator
HRD68_09415	COG2194	sulfuric ester hydrolase activity
HRD68_09420	COG1764	response to oxidative stress
HRD68_09435	COG2986	histidine ammonia-lyase
HRD68_09440	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HRD68_09445	COG5001	Diguanylate cyclase
HRD68_09450	COG1024	Enoyl-CoA hydratase
HRD68_09455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD68_09465	COG2860	membrane
HRD68_09470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRD68_09480	COG1758	RNA polymerase activity
HRD68_09485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD68_09490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD68_09495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRD68_09500	COG0786	glutamate:sodium symporter activity
HRD68_09505	COG2233	PERMEase
HRD68_09510	COG2982	Protein involved in outer membrane biogenesis
HRD68_09530	COG0456	acetyltransferase
HRD68_09540	COG1295	ribonuclease BN
HRD68_09545	COG1011	Hydrolase
HRD68_09560	COG3852	Histidine kinase
HRD68_09570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRD68_09575	COG3078	GTPase activator activity
HRD68_09580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HRD68_09585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD68_09585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD68_09590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRD68_09595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HRD68_09600	COG3084	Protein conserved in bacteria
HRD68_09610	COG1763	Mo-molybdopterin cofactor biosynthetic process
HRD68_09635	COG2186	Transcriptional regulator
HRD68_09640	COG0477	Major facilitator Superfamily
HRD68_09645	COG1609	Transcriptional regulator
HRD68_09650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD68_09655	COG1879	ABC-type sugar transport system periplasmic component
HRD68_09660	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_09670	COG1869	D-ribose catabolic process
HRD68_09675	COG3158	transport of potassium into the cell
HRD68_09680	COG0714	Associated with various cellular activities
HRD68_09685	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HRD68_09695	COG2502	aspartate--ammonia ligase
HRD68_09700	COG1522	sequence-specific DNA binding
HRD68_09705	COG0716	FMN binding
HRD68_09710	COG0445	tRNA wobble uridine modification
HRD68_09715	COG0357	Ribosomal RNA small subunit methyltransferase G
HRD68_09720	COG3312	ion transport
HRD68_09725	COG0356	it plays a direct role in the translocation of protons across the membrane
HRD68_09735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRD68_09740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRD68_09745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRD68_09750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRD68_09755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRD68_09760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRD68_09765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRD68_09775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRD68_09780	COG0573	inorganic phosphate transmembrane transporter activity
HRD68_09785	COG0581	inorganic phosphate transmembrane transporter activity
HRD68_09795	COG0704	Plays a role in the regulation of phosphate uptake
HRD68_09800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_09805	COG0765	amino acid transport
HRD68_09810	COG0765	amino acid transport
HRD68_09815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD68_09820	COG2252	PERMEase
HRD68_09835	COG4191	Histidine kinase
HRD68_09840	COG0431	NADPH-dependent FMN reductase
HRD68_09845	COG0840	transmembrane signaling receptor activity
HRD68_09850	COG2011	ABC-type metal ion transport system permease component
HRD68_09855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRD68_09885	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRD68_09890	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRD68_09895	COG0706	membrane insertase activity
HRD68_09905	COG0594	ribonuclease P activity
HRD68_09910	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRD68_09915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRD68_09920	COG0592	DNA-directed DNA polymerase activity
HRD68_09930	COG0187	DNA topoisomerase II activity
HRD68_09935	COG0561	phosphatase activity
HRD68_09940	COG2423	ornithine cyclodeaminase activity
HRD68_09955	COG0823	Involved in the tonB-independent uptake of proteins
HRD68_09960	COG5645	(Lipo)protein
HRD68_09975	COG2985	domain, Protein
HRD68_09975	COG0569	domain protein
HRD68_09980	COG3977	Valine--pyruvate aminotransferase
HRD68_09985	COG0366	Alpha amylase catalytic
HRD68_10005	COG2885	chlorophyll binding
HRD68_10020	COG2818	Glycosylase
HRD68_10030	COG0752	glycyl-tRNA synthetase alpha subunit
HRD68_10035	COG0751	glycine-tRNA ligase activity
HRD68_10050	COG3276	selenocysteine insertion sequence binding
HRD68_10055	COG1921	L-seryl-tRNASec selenium transferase activity
HRD68_10060	COG3058	Necessary for formate dehydrogenase activity
HRD68_10065	COG2864	formate dehydrogenase
HRD68_10070	COG0437	4 iron, 4 sulfur cluster binding
HRD68_10080	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HRD68_10085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRD68_10090	COG0840	transmembrane signaling receptor activity
HRD68_10095	COG2258	MOSC domain
HRD68_10110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD68_10120	COG3722	fumarate hydratase activity
HRD68_10125	COG0246	Mannitol dehydrogenase
HRD68_10130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_10130	COG2213	PTS system mannitol-specific
HRD68_10135	COG3274	enterobacterial common antigen metabolic process
HRD68_10145	COG1335	isochorismatase
HRD68_10155	COG3188	usher protein
HRD68_10160	COG3121	Chaperone
HRD68_10170	COG1070	Carbohydrate kinase
HRD68_10175	COG2115	Belongs to the xylose isomerase family
HRD68_10180	COG4213	ABC transporter substrate-binding protein
HRD68_10190	COG4214	carbohydrate transport
HRD68_10195	COG2207	Transcriptional regulator
HRD68_10195	COG1609	Transcriptional regulator
HRD68_10205	COG0582	viral genome integration into host DNA
HRD68_10215	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRD68_10235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRD68_10290	COG2003	Belongs to the UPF0758 family
HRD68_10335	COG4529	Protein conserved in bacteria
HRD68_10355	COG1561	YicC-like family, N-terminal region
HRD68_10360	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HRD68_10365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HRD68_10370	COG1301	dicarboxylic acid transport
HRD68_10375	COG0612	Peptidase, M16
HRD68_10380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD68_10385	COG1942	4-Oxalocrotonate Tautomerase
HRD68_10390	COG2200	EAL domain
HRD68_10395	COG2982	Protein involved in outer membrane biogenesis
HRD68_10400	COG2134	cdp-diacylglycerol pyrophosphatase
HRD68_10405	COG1295	ribonuclease BN
HRD68_10410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD68_10415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HRD68_10430	COG0742	ribosomal rna small subunit methyltransferase
HRD68_10445	COG0589	response to stress
HRD68_10455	COG0306	phosphate transporter
HRD68_10460	COG2081	HI0933 family
HRD68_10465	COG2197	response regulator
HRD68_10480	COG0583	DNA-binding transcription factor activity
HRD68_10485	COG2814	Major facilitator Superfamily
HRD68_10495	COG2814	Major facilitator Superfamily
HRD68_10505	COG3718	enzyme involved in inositol metabolism
HRD68_10525	COG0673	inositol 2-dehydrogenase activity
HRD68_10530	COG1082	Xylose isomerase domain protein TIM barrel
HRD68_10535	COG1247	-acetyltransferase
HRD68_10540	COG1741	Belongs to the pirin family
HRD68_10545	COG1609	Transcriptional regulator
HRD68_10550	COG2610	gluconate transmembrane transporter activity
HRD68_10555	COG3265	gluconokinase activity
HRD68_10560	COG2095	MarC family integral membrane protein
HRD68_10565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRD68_10570	COG3275	phosphorelay sensor kinase activity
HRD68_10575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRD68_10580	COG1523	belongs to the glycosyl hydrolase 13 family
HRD68_10590	COG0297	glycogen (starch) synthase activity
HRD68_10595	COG0058	SHG alpha-glucan phosphorylase activity
HRD68_10600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRD68_10605	COG1349	DNA-binding transcription factor activity
HRD68_10610	COG0705	Rhomboid family
HRD68_10625	COG2909	trisaccharide binding
HRD68_10630	COG0058	SHG alpha-glucan phosphorylase activity
HRD68_10635	COG1640	4-alpha-glucanotransferase
HRD68_10640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HRD68_10640	COG0316	Belongs to the HesB IscA family
HRD68_10645	COG1040	competence protein
HRD68_10650	COG0596	Alpha beta hydrolase
HRD68_10670	COG1918	ferrous iron import across plasma membrane
HRD68_10675	COG2183	response to ionizing radiation
HRD68_10680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRD68_10685	COG0745	RESPONSE REGULATOR receiver
HRD68_10705	COG3121	Chaperone
HRD68_10710	COG3188	usher protein
HRD68_10730	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HRD68_10740	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HRD68_10745	COG1011	Hydrolase
HRD68_10755	COG0494	nUDIX hydrolase
HRD68_10760	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRD68_10785	COG4796	Type ii and iii secretion system protein
HRD68_10790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRD68_10810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRD68_10820	COG0180	Tryptophanyl-tRNA synthetase
HRD68_10825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRD68_10825	COG1648	precorrin-2 dehydrogenase activity
HRD68_10840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD68_10845	COG0402	S-adenosylhomocysteine deaminase activity
HRD68_10850	COG0738	Major facilitator superfamily
HRD68_10860	COG4771	TonB-dependent receptor
HRD68_10870	COG1486	melibiose metabolic process
HRD68_10875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRD68_10880	COG0433	COG0433 Predicted ATPase
HRD68_10925	COG1470	cell adhesion involved in biofilm formation
HRD68_10925	COG1388	LysM domain
HRD68_10940	COG1289	transmembrane transporter activity
HRD68_10950	COG1765	OsmC-like protein
HRD68_10955	COG3954	Phosphoribulokinase
HRD68_10960	COG3089	Belongs to the UPF0270 family
HRD68_10965	COG0429	hydrolase of the alpha beta-hydrolase fold
HRD68_10980	COG4521	taurine ABC transporter
HRD68_10990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRD68_10995	COG2175	clavaminate synthase activity
HRD68_11005	COG0488	(ABC) transporter
HRD68_11010	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRD68_11020	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HRD68_11025	COG1047	Peptidyl-prolyl cis-trans
HRD68_11035	COG0545	Peptidyl-prolyl cis-trans isomerase
HRD68_11040	COG2964	Protein conserved in bacteria
HRD68_11045	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HRD68_11055	COG2168	tRNA wobble position uridine thiolation
HRD68_11060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRD68_11065	COG0049	tRNA binding
HRD68_11075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRD68_11090	COG0051	transcription antitermination factor activity, RNA binding
HRD68_11095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRD68_11100	COG0088	Forms part of the polypeptide exit tunnel
HRD68_11105	COG0089	rRNA binding
HRD68_11115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRD68_11120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRD68_11125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRD68_11130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRD68_11135	COG0255	Belongs to the universal ribosomal protein uL29 family
HRD68_11140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRD68_11145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRD68_11160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRD68_11170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRD68_11175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRD68_11180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRD68_11185	COG1841	ribosomal large subunit assembly
HRD68_11190	COG0200	Binds to the 23S rRNA
HRD68_11195	COG0201	protein transport
HRD68_11200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRD68_11205	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRD68_11210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRD68_11215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRD68_11225	COG0203	ribosomal protein L17
HRD68_11235	COG0789	Transcriptional regulator
HRD68_11240	COG3036	rescue of stalled ribosome
HRD68_11245	COG1970	mechanosensitive ion channel activity
HRD68_11255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRD68_11255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRD68_11260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRD68_11265	COG0242	peptide deformylase activity
HRD68_11270	COG0758	DNA mediated transformation
HRD68_11280	COG0551	DNA topoisomerase type I activity
HRD68_11285	COG0009	L-threonylcarbamoyladenylate synthase
HRD68_11290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRD68_11295	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HRD68_11325	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HRD68_11330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HRD68_11335	COG2224	Isocitrate lyase
HRD68_11340	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HRD68_11345	COG1414	Transcriptional regulator
HRD68_11350	COG0646	methionine synthase
HRD68_11350	COG1410	methionine synthase
HRD68_11360	COG0527	aspartate kinase activity
HRD68_11375	COG3833	ABC-type maltose transport systems, permease component
HRD68_11380	COG1175	transmembrane transport
HRD68_11385	COG2182	Extracellular solute-binding protein
HRD68_11395	COG4580	involved in the transport of maltose and maltodextrins
HRD68_11405	COG3161	chorismate lyase activity
HRD68_11415	COG2937	Belongs to the GPAT DAPAT family
HRD68_11420	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HRD68_11425	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRD68_11430	COG3237	CsbD-like
HRD68_11435	COG0735	belongs to the Fur family
HRD68_11445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD68_11470	COG1448	Aminotransferase
HRD68_11475	COG2315	Protein conserved in bacteria
HRD68_11480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRD68_11485	COG0629	single-stranded DNA binding
HRD68_11505	COG2252	PERMEase
HRD68_11510	COG0025	NhaP-type Na H and K H
HRD68_11515	COG0583	DNA-binding transcription factor activity
HRD68_11520	COG1380	Effector of murein hydrolase LrgA
HRD68_11525	COG1346	cytolysis
HRD68_11530	COG1126	abc transporter atp-binding protein
HRD68_11535	COG0765	amino acid transport
HRD68_11540	COG4597	amino acid ABC transporter
HRD68_11545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_11555	COG1560	Kdo2-lipid A biosynthetic process
HRD68_11565	COG1129	ABC transporter
HRD68_11570	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_11580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD68_11590	COG0471	metal ion transport
HRD68_11595	COG1278	Cold shock
HRD68_11600	COG1278	Cold shock
HRD68_11605	COG3133	Outer membrane lipoprotein
HRD68_11620	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HRD68_11625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD68_11630	COG2264	protein methyltransferase activity
HRD68_11635	COG4145	pantothenate transmembrane transporter activity
HRD68_11640	COG3924	membrane
HRD68_11645	COG0439	Biotin carboxylase
HRD68_11650	COG0511	ligase activity, forming carbon-carbon bonds
HRD68_11660	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HRD68_11670	COG0604	alcohol dehydrogenase
HRD68_11675	COG2199	diguanylate cyclase activity
HRD68_11675	COG2200	EAL domain
HRD68_11680	COG1077	Cell shape determining protein MreB Mrl
HRD68_11685	COG1792	Involved in formation and maintenance of cell shape
HRD68_11690	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HRD68_11695	COG0424	maF-like protein
HRD68_11700	COG1530	ribonuclease E activity
HRD68_11705	COG3164	Protein of unknown function
HRD68_11710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD68_11715	COG0312	modulator of DNA gyrase
HRD68_11720	COG0583	DNA-binding transcription factor activity
HRD68_11730	COG1566	PFAM secretion protein HlyD family protein
HRD68_11735	COG1289	transmembrane transporter activity
HRD68_11750	COG2732	(Barnase) inhibitor
HRD68_11755	COG3028	Belongs to the UPF0307 family
HRD68_11760	COG0312	modulator of DNA gyrase
HRD68_11770	COG3783	Cytochrome b(562)
HRD68_11775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRD68_11805	COG3964	amidohydrolase
HRD68_11820	COG3711	transcriptional antiterminator
HRD68_11820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_11830	COG1609	Transcriptional regulator
HRD68_11835	COG1263	PTS System
HRD68_11835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_11840	COG0366	Alpha amylase catalytic
HRD68_11870	COG2308	Evidence 4 Homologs of previously reported genes of
HRD68_11880	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HRD68_11885	COG0540	Belongs to the ATCase OTCase family
HRD68_11890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_11910	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HRD68_11915	COG1137	ATPase activity
HRD68_11920	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HRD68_11925	COG3117	lipopolysaccharide transmembrane transporter activity
HRD68_11930	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HRD68_11935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HRD68_11935	COG0517	IMP dehydrogenase activity
HRD68_11940	COG0530	calcium, potassium:sodium antiporter activity
HRD68_11945	COG1127	ABC transporter
HRD68_11950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRD68_11955	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRD68_11960	COG2854	intermembrane phospholipid transfer
HRD68_11965	COG3113	response to antibiotic
HRD68_11970	COG5007	Belongs to the BolA IbaG family
HRD68_11975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRD68_11980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD68_11985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD68_11990	COG3105	Protein conserved in bacteria
HRD68_12000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRD68_12005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRD68_12010	COG0625	glutathione transferase activity
HRD68_12015	COG2969	positive regulation of protein catabolic process
HRD68_12025	COG0493	'glutamate synthase
HRD68_12030	COG0070	glutamate synthase
HRD68_12030	COG0069	glutamate synthase activity
HRD68_12030	COG0067	glutamate synthase
HRD68_12035	COG1242	4 iron, 4 sulfur cluster binding
HRD68_12040	COG0784	Response regulator, receiver
HRD68_12040	COG2198	Histidine kinase
HRD68_12040	COG5002	protein histidine kinase activity
HRD68_12045	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HRD68_12050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD68_12055	COG2823	Periplasmic or secreted lipoprotein
HRD68_12060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HRD68_12065	COG0792	nuclease activity
HRD68_12075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRD68_12110	COG1064	alcohol dehydrogenase
HRD68_12115	COG1741	Belongs to the pirin family
HRD68_12120	COG0583	DNA-binding transcription factor activity
HRD68_12125	COG0435	Glutathione S-transferase
HRD68_12130	COG2259	Doxx family
HRD68_12140	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HRD68_12145	COG4575	ribosome binding
HRD68_12160	COG0586	Pfam SNARE associated Golgi protein
HRD68_12175	COG2271	Major facilitator Superfamily
HRD68_12180	COG1904	glucuronate isomerase
HRD68_12185	COG0246	Mannitol dehydrogenase
HRD68_12190	COG2721	sulfolactate sulfo-lyase activity
HRD68_12200	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HRD68_12205	COG0861	Integral membrane protein TerC family
HRD68_12215	COG0673	inositol 2-dehydrogenase activity
HRD68_12220	COG1451	nucleotide metabolic process
HRD68_12225	COG2813	Specifically methylates the guanine in position
HRD68_12235	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRD68_12235	COG1902	pentaerythritol trinitrate reductase activity
HRD68_12240	COG3247	response to pH
HRD68_12250	COG0800	Aldolase
HRD68_12255	COG2271	Major facilitator Superfamily
HRD68_12270	COG1454	alcohol dehydrogenase
HRD68_12275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD68_12290	COG4974	Belongs to the 'phage' integrase family
HRD68_12350	COG4695	Portal protein
HRD68_12425	COG2856	Zn peptidase
HRD68_12515	COG0358	DNA primase activity
HRD68_12520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRD68_12525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRD68_12530	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HRD68_12535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HRD68_12540	COG1968	undecaprenyl-diphosphatase activity
HRD68_12545	COG0617	tRNA 3'-terminal CCA addition
HRD68_12550	COG4991	sh3 domain protein
HRD68_12555	COG3025	triphosphatase activity
HRD68_12560	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HRD68_12565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRD68_12565	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HRD68_12570	COG0531	amino acid
HRD68_12580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRD68_12585	COG3384	dioxygenase
HRD68_12590	COG0754	glutathionylspermidine amidase activity
HRD68_12595	COG5463	Belongs to the UPF0441 family
HRD68_12600	COG1538	Outer membrane efflux protein
HRD68_12605	COG0494	nUDIX hydrolase
HRD68_12610	COG3151	Protein conserved in bacteria
HRD68_12615	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HRD68_12620	COG3150	esterase
HRD68_12635	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HRD68_12640	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRD68_12650	COG0204	Acyl-transferase
HRD68_12655	COG2132	Multicopper oxidase
HRD68_12665	COG0656	L-ascorbic acid biosynthetic process
HRD68_12670	COG1979	alcohol dehydrogenase
HRD68_12675	COG2207	Transcriptional regulator
HRD68_12680	COG0586	Pfam SNARE associated Golgi protein
HRD68_12685	COG0626	cystathionine gamma-synthase activity
HRD68_12695	COG0848	biopolymer transport protein
HRD68_12745	COG4964	Belongs to the GSP D family
HRD68_12770	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD68_12775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_12800	COG1120	ATPase activity
HRD68_12805	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD68_12810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD68_12830	COG1609	Transcriptional regulator
HRD68_12840	COG4592	Periplasmic binding protein
HRD68_12845	COG0840	transmembrane signaling receptor activity
HRD68_12860	COG3710	Transcriptional regulator
HRD68_12865	COG3133	Outer membrane lipoprotein
HRD68_12870	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HRD68_12875	COG0437	4 iron, 4 sulfur cluster binding
HRD68_12880	COG5557	Pfam Polysulphide reductase, NrfD
HRD68_12885	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HRD68_12890	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HRD68_12895	COG1773	rubredoxin
HRD68_12905	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRD68_12910	COG0298	carbon dioxide binding
HRD68_12915	COG0409	Hydrogenase expression formation protein
HRD68_12920	COG0309	Hydrogenase expression formation protein (HypE)
HRD68_12925	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HRD68_12935	COG5001	Diguanylate cyclase
HRD68_12940	COG0471	metal ion transport
HRD68_12945	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD68_12950	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD68_12960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_12975	COG4303	Ethanolamine ammonia lyase large subunit
HRD68_12980	COG4302	ethanolamine ammonia-lyase activity
HRD68_12985	COG0477	Major facilitator Superfamily
HRD68_13010	COG1609	Transcriptional regulator
HRD68_13015	COG0477	Major facilitator Superfamily
HRD68_13020	COG4607	ABC-type enterochelin transport system periplasmic component
HRD68_13030	COG4605	iron ion homeostasis
HRD68_13035	COG4604	ABC transporter, ATP-binding protein
HRD68_13040	COG0024	Methionine aminopeptidase
HRD68_13060	COG2222	sugar isomerase
HRD68_13065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRD68_13070	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_13075	COG3716	PTS system mannose fructose sorbose family IID component
HRD68_13085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_13095	COG1349	DNA-binding transcription factor activity
HRD68_13100	COG2226	methyltransferase
HRD68_13105	COG0747	negative chemotaxis
HRD68_13110	COG0601	transmembrane transport
HRD68_13115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD68_13120	COG0444	Belongs to the ABC transporter superfamily
HRD68_13125	COG1124	(ABC) transporter
HRD68_13130	COG2831	hemolysin activation secretion protein
HRD68_13135	COG3210	domain, Protein
HRD68_13215	COG2885	chlorophyll binding
HRD68_13245	COG0791	NLP P60 protein
HRD68_13245	COG1388	LysM domain
HRD68_13305	COG1228	amidohydrolase
HRD68_13320	COG1289	transmembrane transporter activity
HRD68_13390	COG4964	Belongs to the GSP D family
HRD68_13440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRD68_13460	COG2373	Large extracellular alpha-helical protein
HRD68_13460	COG1388	LysM domain
HRD68_13460	COG4932	domain protein
HRD68_13480	COG0840	transmembrane signaling receptor activity
HRD68_13485	COG2197	response regulator
HRD68_13510	COG2747	anti-sigma28 factor FlgM
HRD68_13520	COG1815	bacterial-type flagellum-dependent cell motility
HRD68_13530	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HRD68_13570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRD68_13575	COG1191	sigma factor activity
HRD68_13600	COG2198	Histidine kinase
HRD68_13600	COG0643	Histidine kinase
HRD68_13605	COG0835	chemotaxis
HRD68_13650	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD68_13660	COG0745	RESPONSE REGULATOR receiver
HRD68_13670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HRD68_13675	COG1677	Flagellar hook-basal body complex protein FliE
HRD68_13680	COG1766	The M ring may be actively involved in energy transduction
HRD68_13690	COG1317	bacterial-type flagellum organization
HRD68_13695	COG1157	protein secretion by the type III secretion system
HRD68_13705	COG3144	bacterial-type flagellum assembly
HRD68_13710	COG1580	Controls the rotational direction of flagella during chemotaxis
HRD68_13720	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRD68_13735	COG1987	bacterial-type flagellum assembly
HRD68_13750	COG0745	RESPONSE REGULATOR receiver
HRD68_13775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRD68_13790	COG0673	inositol 2-dehydrogenase activity
HRD68_13795	COG0823	Involved in the tonB-independent uptake of proteins
HRD68_13800	COG1653	transport
HRD68_13805	COG1082	Xylose isomerase domain protein TIM barrel
HRD68_13810	COG0626	cystathionine gamma-synthase activity
HRD68_13815	COG0814	amino acid
HRD68_13820	COG0583	DNA-binding transcription factor activity
HRD68_13830	COG3655	Transcriptional regulator
HRD68_13845	COG3121	Chaperone
HRD68_13850	COG3188	usher protein
HRD68_13865	COG2197	response regulator
HRD68_13875	COG1982	Orn Lys Arg decarboxylase major
HRD68_13880	COG0741	lytic transglycosylase activity
HRD68_13890	COG1194	a g-specific adenine glycosylase
HRD68_13895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRD68_13900	COG3171	Protein conserved in bacteria
HRD68_13915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRD68_13925	COG1872	DUF167
HRD68_13930	COG0762	integral membrane protein
HRD68_13935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRD68_13940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRD68_13945	COG2805	Type II/IV secretion system protein
HRD68_13955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD68_13960	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRD68_13965	COG1678	Uncharacterized ACR, COG1678
HRD68_13970	COG0189	ligase activity
HRD68_13975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRD68_13980	COG2356	endonuclease I
HRD68_13985	COG3091	SprT-like family
HRD68_13990	COG0640	Transcriptional regulator
HRD68_14005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRD68_14010	COG1166	arginine decarboxylase activity
HRD68_14020	COG0501	Belongs to the peptidase M48B family
HRD68_14025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRD68_14030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRD68_14035	COG0126	phosphoglycerate kinase activity
HRD68_14040	COG0191	fructose-bisphosphate aldolase activity
HRD68_14055	COG1279	arginine transmembrane transporter activity
HRD68_14065	COG0583	DNA-binding transcription factor activity
HRD68_14070	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HRD68_14075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD68_14080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRD68_14090	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HRD68_14095	COG3079	Belongs to the UPF0149 family
HRD68_14100	COG0006	proline dipeptidase activity
HRD68_14105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD68_14110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD68_14115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRD68_14120	COG0509	glycine decarboxylation via glycine cleavage system
HRD68_14125	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRD68_14125	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRD68_14130	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_14135	COG1272	protein, Hemolysin III
HRD68_14140	COG0354	folic acid binding
HRD68_14155	COG0745	RESPONSE REGULATOR receiver
HRD68_14160	COG2205	protein histidine kinase activity
HRD68_14165	COG4452	Inner membrane protein CreD
HRD68_14170	COG0716	FMN binding
HRD68_14175	COG4974	Belongs to the 'phage' integrase family
HRD68_14180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRD68_14185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRD68_14210	COG0656	L-ascorbic acid biosynthetic process
HRD68_14230	COG3706	GGDEF domain
HRD68_14235	COG1522	sequence-specific DNA binding
HRD68_14250	COG2271	Major facilitator Superfamily
HRD68_14260	COG0484	heat shock protein binding
HRD68_14270	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_14275	COG1733	regulation of RNA biosynthetic process
HRD68_14310	COG0583	DNA-binding transcription factor activity
HRD68_14315	COG2814	Major facilitator Superfamily
HRD68_14320	COG0583	DNA-binding transcription factor activity
HRD68_14330	COG1609	Transcriptional regulator
HRD68_14340	COG0204	Acyl-transferase
HRD68_14340	COG0318	PFAM AMP-dependent synthetase and ligase
HRD68_14345	COG0477	Major facilitator Superfamily
HRD68_14350	COG5499	transcription regulator containing HTH domain
HRD68_14355	COG0667	Aldo Keto reductase
HRD68_14360	COG0861	Integral membrane protein TerC family
HRD68_14365	COG3066	DNA modification
HRD68_14370	COG1051	belongs to the nudix hydrolase family
HRD68_14380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRD68_14390	COG2165	general secretion pathway protein
HRD68_14410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HRD68_14415	COG1025	Belongs to the peptidase M16 family
HRD68_14420	COG1074	ATP-dependent DNA helicase activity
HRD68_14425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRD68_14430	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HRD68_14430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRD68_14435	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRD68_14455	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HRD68_14460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HRD68_14465	COG2166	iron-sulfur cluster assembly
HRD68_14470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRD68_14480	COG0583	DNA-binding transcription factor activity
HRD68_14485	COG2363	Small membrane protein
HRD68_14490	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HRD68_14500	COG1611	Belongs to the LOG family
HRD68_14505	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRD68_14505	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRD68_14515	COG3098	single-species biofilm formation
HRD68_14520	COG0564	pseudouridine synthase activity
HRD68_14540	COG2171	N-acyltransferase activity
HRD68_14545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HRD68_14560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRD68_14565	COG0528	UMP kinase activity
HRD68_14575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRD68_14585	COG0575	Belongs to the CDS family
HRD68_14590	COG0750	zinc metalloprotease
HRD68_14600	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HRD68_14605	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD68_14615	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD68_14625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRD68_14630	COG0587	DNA-directed DNA polymerase activity
HRD68_14635	COG0825	malonyl-CoA metabolic process
HRD68_14640	COG0346	lactoylglutathione lyase activity
HRD68_14655	COG4568	rho-dependent transcription termination
HRD68_14665	COG4681	YaeQ
HRD68_14675	COG3015	lipoprotein NlpE involved in copper resistance
HRD68_14680	COG0442	prolyl-tRNA aminoacylation
HRD68_14685	COG1720	tRNA m6t6A37 methyltransferase activity
HRD68_14695	COG1464	Belongs to the NlpA lipoprotein family
HRD68_14700	COG2011	ABC-type metal ion transport system permease component
HRD68_14710	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HRD68_14745	COG0583	DNA-binding transcription factor activity
HRD68_14750	COG0656	L-ascorbic acid biosynthetic process
HRD68_14755	COG3021	interspecies interaction between organisms
HRD68_14760	COG1388	LysM domain
HRD68_14760	COG0741	lytic transglycosylase activity
HRD68_14765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD68_14770	COG2226	methyltransferase
HRD68_14780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD68_14790	COG2113	Glycine betaine
HRD68_14795	COG4176	ABC-type proline glycine betaine transport system permease component
HRD68_14805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD68_14815	COG1780	Probably involved in ribonucleotide reductase function
HRD68_14825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD68_14835	COG4575	ribosome binding
HRD68_14860	COG0747	negative chemotaxis
HRD68_14870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD68_14875	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HRD68_14890	COG0831	urea catabolic process
HRD68_14895	COG0832	Belongs to the urease beta subunit family
HRD68_14900	COG0804	urea catabolic process
HRD68_14905	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HRD68_14915	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRD68_14925	COG4413	Urea transporter
HRD68_14930	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HRD68_14940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRD68_14955	COG2133	pyrroloquinoline quinone binding
HRD68_14960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD68_14965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD68_14970	COG1447	Phosphotransferase system cellobiose-specific component IIA
HRD68_14975	COG2169	Transcriptional regulator
HRD68_14975	COG1917	Cupin 2, conserved barrel domain protein
HRD68_14980	COG3394	polysaccharide catabolic process
HRD68_14990	COG1595	DNA-templated transcription, initiation
HRD68_14995	COG3712	iron ion homeostasis
HRD68_15000	COG4772	TonB-dependent receptor
HRD68_15005	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HRD68_15010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD68_15015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD68_15020	COG1120	ATPase activity
HRD68_15035	COG0789	Transcriptional regulator
HRD68_15050	COG0251	oxidation-reduction process
HRD68_15055	COG0563	adenylate kinase activity
HRD68_15070	COG1401	restriction endodeoxyribonuclease activity
HRD68_15120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRD68_15125	COG2867	negative regulation of translational initiation
HRD68_15135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD68_15140	COG0497	DNA recombination
HRD68_15145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRD68_15150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRD68_15155	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRD68_15160	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HRD68_15165	COG0513	Belongs to the DEAD box helicase family
HRD68_15170	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HRD68_15175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HRD68_15190	COG3026	antisigma factor binding
HRD68_15195	COG3086	response to oxidative stress
HRD68_15225	COG1381	Involved in DNA repair and RecF pathway recombination
HRD68_15230	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HRD68_15235	COG0736	holo-[acyl-carrier-protein] synthase activity
HRD68_15240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_15245	COG1737	Transcriptional regulator
HRD68_15250	COG0560	Phosphoserine phosphatase
HRD68_15260	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HRD68_15275	COG2205	protein histidine kinase activity
HRD68_15280	COG3170	Tfp pilus assembly protein FimV
HRD68_15285	COG2204	response regulator
HRD68_15290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRD68_15290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD68_15295	COG0347	Belongs to the P(II) protein family
HRD68_15310	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HRD68_15315	COG3457	Alanine racemase
HRD68_15325	COG2188	Transcriptional regulator
HRD68_15330	COG1017	nitric oxide dioxygenase activity
HRD68_15330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD68_15340	COG2814	Major facilitator Superfamily
HRD68_15345	COG3711	transcriptional antiterminator
HRD68_15350	COG3683	transport system, periplasmic component
HRD68_15355	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HRD68_15360	COG0483	inositol monophosphate 1-phosphatase activity
HRD68_15365	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HRD68_15370	COG1959	2 iron, 2 sulfur cluster binding
HRD68_15380	COG0822	iron-sulfur transferase activity
HRD68_15390	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HRD68_15395	COG0443	Heat shock 70 kDa protein
HRD68_15400	COG0633	Ferredoxin
HRD68_15405	COG2975	iron-sulfur cluster assembly
HRD68_15420	COG3468	outer membrane autotransporter barrel domain protein
HRD68_15425	COG2373	Large extracellular alpha-helical protein
HRD68_15430	COG4953	penicillin-binding protein 1C
HRD68_15455	COG1426	Protein conserved in bacteria
HRD68_15470	COG2976	Protein conserved in bacteria
HRD68_15475	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD68_15480	COG1160	GTP binding
HRD68_15490	COG1645	bacterial-type flagellum-dependent swarming motility
HRD68_15495	COG1570	exodeoxyribonuclease VII activity
HRD68_15500	COG0516	GMP reductase activity
HRD68_15500	COG0517	IMP dehydrogenase activity
HRD68_15505	COG0519	Catalyzes the synthesis of GMP from XMP
HRD68_15505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRD68_15515	COG3710	Transcriptional regulator
HRD68_15525	COG2197	response regulator
HRD68_15540	COG3121	Chaperone
HRD68_15550	COG3121	Chaperone
HRD68_15555	COG3121	Chaperone
HRD68_15570	COG0351	phosphomethylpyrimidine kinase
HRD68_15590	COG1349	DNA-binding transcription factor activity
HRD68_15595	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_15600	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_15615	COG3730	PTS system glucitol sorbitol-specific
HRD68_15620	COG1597	lipid kinase activity
HRD68_15630	COG3422	double-strand break repair
HRD68_15635	COG0745	RESPONSE REGULATOR receiver
HRD68_15640	COG2205	protein histidine kinase activity
HRD68_15645	COG0477	Major facilitator Superfamily
HRD68_15650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD68_15660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_15685	COG0443	Heat shock 70 kDa protein
HRD68_15690	COG5001	Diguanylate cyclase
HRD68_15690	COG5002	protein histidine kinase activity
HRD68_15690	COG3447	MASE1 domain protein
HRD68_15695	COG2239	Acts as a magnesium transporter
HRD68_15710	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRD68_15720	COG0581	inorganic phosphate transmembrane transporter activity
HRD68_15730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD68_15735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRD68_15745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRD68_15750	COG2233	PERMEase
HRD68_15755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRD68_15760	COG1393	Belongs to the ArsC family
HRD68_15765	COG4783	chaperone-mediated protein folding
HRD68_15770	COG0628	permease
HRD68_15775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRD68_15780	COG2716	regulation of RNA biosynthetic process
HRD68_15785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD68_15790	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HRD68_15795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRD68_15800	COG2321	neutral zinc metallopeptidase
HRD68_15805	COG2707	UPF0756 membrane protein
HRD68_15810	COG1444	tRNA N-acetyltransferase activity
HRD68_15815	COG0400	carboxylic ester hydrolase activity
HRD68_15825	COG1876	peptidase activity
HRD68_15830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD68_15835	COG1393	Belongs to the ArsC family
HRD68_15840	COG0583	DNA-binding transcription factor activity
HRD68_15845	COG2197	response regulator
HRD68_15860	COG1175	transmembrane transport
HRD68_15865	COG3842	ATPase activity
HRD68_15870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD68_15880	COG2197	response regulator
HRD68_15885	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_15885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_15890	COG3062	negative regulation of establishment of protein localization
HRD68_15895	COG0243	molybdopterin cofactor binding
HRD68_15900	COG3043	anaerobic respiration
HRD68_15905	COG3005	denitrification pathway
HRD68_15910	COG0494	nUDIX hydrolase
HRD68_15925	COG0408	coproporphyrinogen oxidase activity
HRD68_15930	COG0456	acetyltransferase
HRD68_15940	COG1129	ABC transporter
HRD68_15945	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_15970	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_15975	COG3111	PFAM Bacterial OB fold (BOF) protein
HRD68_15985	COG2837	iron assimilation
HRD68_15990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD68_16005	COG2731	YhcH YjgK YiaL family protein
HRD68_16010	COG1737	Transcriptional regulator
HRD68_16025	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HRD68_16030	COG4208	sulfate ABC transporter
HRD68_16065	COG1216	Glycosyl transferase, family 2
HRD68_16095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_16100	COG0745	RESPONSE REGULATOR receiver
HRD68_16105	COG2205	protein histidine kinase activity
HRD68_16120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_16130	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HRD68_16140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRD68_16145	COG3530	Putative quorum-sensing-regulated virulence factor
HRD68_16170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRD68_16205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD68_16215	COG1914	H( )-stimulated, divalent metal cation uptake system
HRD68_16225	COG0667	Aldo Keto reductase
HRD68_16230	COG3961	Belongs to the TPP enzyme family
HRD68_16245	COG0837	glucose binding
HRD68_16250	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HRD68_16260	COG2223	nitrite transmembrane transporter activity
HRD68_16265	COG3279	Response regulator of the LytR AlgR family
HRD68_16270	COG3275	phosphorelay sensor kinase activity
HRD68_16285	COG0436	Aminotransferase
HRD68_16290	COG3038	cytochrome b561
HRD68_16300	COG1598	PFAM Uncharacterised protein family UPF0150
HRD68_16320	COG0406	alpha-ribazole phosphatase activity
HRD68_16350	COG3302	dmso reductase anchor subunit
HRD68_16355	COG0437	4 iron, 4 sulfur cluster binding
HRD68_16360	COG0243	molybdopterin cofactor binding
HRD68_16375	COG2951	lytic endotransglycosylase activity
HRD68_16380	COG0531	amino acid
HRD68_16400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRD68_16405	COG1127	ABC transporter
HRD68_16420	COG3038	cytochrome b561
HRD68_16425	COG2353	YceI-like domain
HRD68_16430	COG1609	Transcriptional regulator
HRD68_16435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_16435	COG1263	PTS System
HRD68_16440	COG2723	6-phospho-beta-galactosidase activity
HRD68_16450	COG1695	Transcriptional regulator
HRD68_16455	COG2824	Alkylphosphonate utilization operon protein PhnA
HRD68_16460	COG2226	methyltransferase
HRD68_16465	COG0076	glutamate decarboxylase activity
HRD68_16470	COG0531	amino acid
HRD68_16485	COG2095	MarC family integral membrane protein
HRD68_16495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_16495	COG2205	protein histidine kinase activity
HRD68_16495	COG2198	Histidine kinase
HRD68_16495	COG0784	Response regulator, receiver
HRD68_16500	COG2197	response regulator
HRD68_16505	COG2181	nitrate reductase activity
HRD68_16510	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HRD68_16515	COG1140	nitrate reductase beta subunit
HRD68_16520	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HRD68_16525	COG2223	nitrite transmembrane transporter activity
HRD68_16530	COG2197	response regulator
HRD68_16535	COG3005	denitrification pathway
HRD68_16540	COG0243	molybdopterin cofactor binding
HRD68_16685	COG0305	Participates in initiation and elongation during chromosome replication
HRD68_16750	COG3772	lysozyme
HRD68_16775	COG5410	chromosome segregation
HRD68_16920	COG0582	viral genome integration into host DNA
HRD68_16930	COG2116	formate transmembrane transporter activity
HRD68_16940	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD68_16945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD68_16950	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD68_16955	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HRD68_16960	COG1138	Cytochrome C-type biogenesis protein
HRD68_16965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD68_16970	COG3088	subunit of a heme lyase
HRD68_16970	COG4235	cytochrome complex assembly
HRD68_16975	COG3088	subunit of a heme lyase
HRD68_16975	COG4235	cytochrome complex assembly
HRD68_17000	COG3691	Protein conserved in bacteria
HRD68_17005	COG0183	Belongs to the thiolase family
HRD68_17010	COG1024	Enoyl-CoA hydratase
HRD68_17010	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD68_17015	COG2062	phosphohistidine phosphatase, SixA
HRD68_17025	COG2840	Smr protein MutS2
HRD68_17030	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD68_17040	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HRD68_17045	COG0730	response to heat
HRD68_17050	COG3101	peptidyl-lysine hydroxylation
HRD68_17060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HRD68_17060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD68_17065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD68_17075	COG1794	racemase activity, acting on amino acids and derivatives
HRD68_17085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HRD68_17100	COG4232	protein-disulfide reductase activity
HRD68_17110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD68_17135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRD68_17145	COG0586	Pfam SNARE associated Golgi protein
HRD68_17150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HRD68_17155	COG0285	dihydrofolate synthase activity
HRD68_17160	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HRD68_17165	COG1286	toxin biosynthetic process
HRD68_17170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HRD68_17180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_17185	COG4215	(ABC) transporter
HRD68_17190	COG4160	amino acid transport
HRD68_17195	COG4598	ABC transporter
HRD68_17200	COG1090	epimerase
HRD68_17210	COG0622	Phosphoesterase
HRD68_17215	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HRD68_17220	COG0561	phosphatase activity
HRD68_17225	COG2706	6-phosphogluconolactonase activity
HRD68_17235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRD68_17240	COG0156	8-amino-7-oxononanoate synthase activity
HRD68_17245	COG2226	methyltransferase
HRD68_17260	COG0556	nucleotide-excision repair
HRD68_17265	COG4628	conserved protein (DUF2132)
HRD68_17270	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HRD68_17275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRD68_17280	COG0315	cyclic pyranopterin monophosphate synthase activity
HRD68_17285	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HRD68_17290	COG0314	molybdopterin synthase activity
HRD68_17295	COG0670	Belongs to the BI1 family
HRD68_17300	COG4774	siderophore transport
HRD68_17315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRD68_17325	COG4592	Periplasmic binding protein
HRD68_17330	COG1169	isochorismate synthase
HRD68_17335	COG1021	2,3-dihydroxybenzoate-AMP ligase
HRD68_17340	COG3433	isochorismatase activity
HRD68_17340	COG1535	isochorismatase
HRD68_17345	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_17350	COG0842	Transport permease protein
HRD68_17355	COG0842	Transport permease protein
HRD68_17360	COG1131	(ABC) transporter
HRD68_17365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD68_17370	COG1309	transcriptional regulator
HRD68_17375	COG0513	Belongs to the DEAD box helicase family
HRD68_17380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD68_17390	COG1686	Belongs to the peptidase S11 family
HRD68_17395	COG0277	FAD linked oxidase domain protein
HRD68_17415	COG2261	transglycosylase associated protein
HRD68_17425	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HRD68_17440	COG4807	Protein conserved in bacteria
HRD68_17470	COG2897	thiosulfate sulfurtransferase activity
HRD68_17485	COG1732	Glycine betaine
HRD68_17490	COG1174	glycine betaine transport
HRD68_17495	COG1125	glycine betaine transport
HRD68_17500	COG1174	glycine betaine transport
HRD68_17510	COG0531	amino acid
HRD68_17515	COG1982	Orn Lys Arg decarboxylase major
HRD68_17525	COG0697	spore germination
HRD68_17540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRD68_17545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRD68_17560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRD68_17565	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HRD68_17575	COG1126	abc transporter atp-binding protein
HRD68_17580	COG0765	amino acid transport
HRD68_17585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_17590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HRD68_17595	COG0783	Belongs to the Dps family
HRD68_17600	COG4106	trans-aconitate 2-methyltransferase activity
HRD68_17615	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HRD68_17630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HRD68_17650	COG0488	(ABC) transporter
HRD68_17655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRD68_17660	COG0303	'Molybdopterin
HRD68_17670	COG0477	Major facilitator Superfamily
HRD68_17685	COG0583	DNA-binding transcription factor activity
HRD68_17690	COG0477	Major facilitator Superfamily
HRD68_17695	COG0302	gtp cyclohydrolase
HRD68_17700	COG2311	Membrane
HRD68_17725	COG2116	formate transmembrane transporter activity
HRD68_17730	COG3604	Transcriptional regulator
HRD68_17735	COG3383	formate dehydrogenase (NAD+) activity
HRD68_17740	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_17745	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HRD68_17755	COG3260	NADH ubiquinone oxidoreductase 20
HRD68_17760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_17765	COG3261	NADH dehydrogenase
HRD68_17765	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HRD68_17770	COG0651	ATP synthesis coupled electron transport
HRD68_17775	COG4237	Hydrogenase 4 membrane
HRD68_17780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRD68_17785	COG0650	Formate hydrogenlyase subunit 4
HRD68_17790	COG0651	ATP synthesis coupled electron transport
HRD68_17795	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD68_17800	COG0375	protein maturation
HRD68_17805	COG0298	carbon dioxide binding
HRD68_17810	COG2949	membrane
HRD68_17815	COG0281	malic enzyme
HRD68_17825	COG1346	cytolysis
HRD68_17830	COG1380	Effector of murein hydrolase LrgA
HRD68_17835	COG2814	Major facilitator Superfamily
HRD68_17850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD68_17850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD68_17855	COG0489	protein tyrosine kinase activity
HRD68_17870	COG2982	Protein involved in outer membrane biogenesis
HRD68_17875	COG3069	C4-dicarboxylate transmembrane transporter activity
HRD68_17880	COG1253	flavin adenine dinucleotide binding
HRD68_17905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD68_17915	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HRD68_17935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRD68_17940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRD68_17945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRD68_17950	COG0140	phosphoribosyl-ATP diphosphatase activity
HRD68_17950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRD68_17955	COG0107	imidazoleglycerol-phosphate synthase activity
HRD68_17960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRD68_17970	COG0131	Imidazoleglycerol-phosphate dehydratase
HRD68_17970	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HRD68_17975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD68_17980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRD68_17985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRD68_17995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD68_18000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_18005	COG1129	ABC transporter
HRD68_18010	COG0371	Dehydrogenase
HRD68_18015	COG0531	amino acid
HRD68_18020	COG2925	Exonuclease
HRD68_18030	COG1289	transmembrane transporter activity
HRD68_18035	COG2926	Belongs to the UPF0265 family
HRD68_18045	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_18050	COG1129	ABC transporter
HRD68_18065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD68_18075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HRD68_18095	COG4656	Part of a membrane complex involved in electron transport
HRD68_18105	COG1012	belongs to the aldehyde dehydrogenase family
HRD68_18190	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HRD68_18200	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HRD68_18265	COG1492	cobalamin metabolic process
HRD68_18285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HRD68_18290	COG0583	DNA-binding transcription factor activity
HRD68_18300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HRD68_18305	COG2211	Major facilitator Superfamily
HRD68_18310	COG0137	argininosuccinate synthase activity
HRD68_18315	COG0534	Mate efflux family protein
HRD68_18320	COG0784	Response regulator, receiver
HRD68_18320	COG0835	chemotaxis
HRD68_18325	COG4221	oxidoreductase activity
HRD68_18330	COG3550	peptidyl-serine autophosphorylation
HRD68_18335	COG3550	peptidyl-serine autophosphorylation
HRD68_18375	COG1187	pseudouridine synthase activity
HRD68_18380	COG3121	Chaperone
HRD68_18395	COG3121	Chaperone
HRD68_18405	COG2205	protein histidine kinase activity
HRD68_18405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD68_18420	COG3842	ATPase activity
HRD68_18430	COG1840	ABC-type Fe3 transport system, periplasmic component
HRD68_18435	COG2271	Major facilitator Superfamily
HRD68_18450	COG4565	transcriptional regulatory protein
HRD68_18455	COG3290	protein histidine kinase activity
HRD68_18460	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HRD68_18465	COG3052	prosthetic group binding
HRD68_18470	COG2301	Belongs to the HpcH HpaI aldolase family
HRD68_18475	COG3051	citrate lyase alpha subunit
HRD68_18485	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HRD68_18490	COG0471	metal ion transport
HRD68_18510	COG0700	Nucleoside recognition
HRD68_18515	COG3366	ferrous iron transmembrane transporter activity
HRD68_18525	COG0471	metal ion transport
HRD68_18530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRD68_18535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HRD68_18540	COG0583	DNA-binding transcription factor activity
HRD68_18550	COG3122	Protein conserved in bacteria
HRD68_18605	COG3615	Tellurite resistance protein tehB
HRD68_18630	COG0583	DNA-binding transcription factor activity
HRD68_18660	COG3228	Belongs to the MtfA family
HRD68_18690	COG0604	alcohol dehydrogenase
HRD68_18690	COG3321	synthase
HRD68_18690	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_18695	COG3250	beta-galactosidase activity
HRD68_18700	COG1609	Transcriptional regulator
HRD68_18715	COG0840	transmembrane signaling receptor activity
HRD68_18720	COG1285	pathogenesis
HRD68_18730	COG2130	NADP-dependent
HRD68_18735	COG0589	response to stress
HRD68_18760	COG2198	Histidine kinase
HRD68_18760	COG0643	Histidine kinase
HRD68_18765	COG0835	chemotaxis
HRD68_18770	COG0840	transmembrane signaling receptor activity
HRD68_18775	COG0840	transmembrane signaling receptor activity
HRD68_18780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HRD68_18790	COG0745	RESPONSE REGULATOR receiver
HRD68_18795	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HRD68_18800	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD68_18805	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD68_18820	COG3418	PFAM FlgN family protein
HRD68_18825	COG2747	anti-sigma28 factor FlgM
HRD68_18835	COG1815	bacterial-type flagellum-dependent cell motility
HRD68_18840	COG1558	bacterial-type flagellum-dependent cell motility
HRD68_18845	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HRD68_18880	COG1256	bacterial-type flagellum assembly
HRD68_18900	COG1338	Plays a role in the flagellum-specific transport system
HRD68_18935	COG1157	protein secretion by the type III secretion system
HRD68_18940	COG1317	bacterial-type flagellum organization
HRD68_18955	COG1677	Flagellar hook-basal body complex protein FliE
HRD68_18960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HRD68_18965	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HRD68_19000	COG1191	sigma factor activity
HRD68_19010	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HRD68_19040	COG0506	proline dehydrogenase activity
HRD68_19040	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRD68_19040	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRD68_19050	COG0672	)-iron permease
HRD68_19055	COG2822	iron ion transport
HRD68_19075	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HRD68_19080	COG2233	PERMEase
HRD68_19085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRD68_19090	COG0778	Nitroreductase
HRD68_19095	COG2267	carboxylic ester hydrolase activity
HRD68_19100	COG0251	oxidation-reduction process
HRD68_19105	COG1335	isochorismatase
HRD68_19110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD68_19115	COG1309	transcriptional regulator
HRD68_19120	COG1113	amino acid transport
HRD68_19130	COG2264	protein methyltransferase activity
HRD68_19145	COG0366	Alpha amylase catalytic
HRD68_19155	COG3136	membrane protein required for alginate biosynthesis
HRD68_19165	COG2197	response regulator
HRD68_19170	COG0322	excinuclease ABC activity
HRD68_19175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRD68_19205	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HRD68_19235	COG1802	Transcriptional regulator
HRD68_19235	COG4626	Terminase
HRD68_19240	COG4725	Belongs to the MT-A70-like family
HRD68_19245	COG3646	Phage regulatory protein
HRD68_19245	COG3645	SOS response
HRD68_19250	COG1403	HNH endonuclease
HRD68_19265	COG3179	chitinase
HRD68_19295	COG4626	Terminase
HRD68_19295	COG1802	Transcriptional regulator
HRD68_19305	COG4695	Portal protein
HRD68_19435	COG3069	C4-dicarboxylate transmembrane transporter activity
HRD68_19440	COG1737	Transcriptional regulator
HRD68_19445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRD68_19475	COG0840	transmembrane signaling receptor activity
HRD68_19485	COG2873	o-acetylhomoserine
HRD68_19490	COG0702	epimerase
HRD68_19495	COG1733	regulation of RNA biosynthetic process
HRD68_19510	COG0246	Mannitol dehydrogenase
HRD68_19515	COG1063	alcohol dehydrogenase
HRD68_19520	COG1802	Transcriptional regulator
HRD68_19525	COG2271	Major facilitator Superfamily
HRD68_19530	COG0697	spore germination
HRD68_19555	COG3706	GGDEF domain
HRD68_19555	COG4251	negative regulation of phosphorylation
HRD68_19555	COG5001	Diguanylate cyclase
HRD68_19555	COG2203	Gaf domain
HRD68_19565	COG1132	(ABC) transporter
HRD68_19580	COG2207	Transcriptional regulator
HRD68_19615	COG1113	amino acid transport
HRD68_19640	COG0768	penicillin binding
HRD68_19655	COG3447	MASE1 domain protein
HRD68_19655	COG5002	protein histidine kinase activity
HRD68_19655	COG5001	Diguanylate cyclase
HRD68_19665	COG1971	Probably functions as a manganese efflux pump
HRD68_19675	COG3716	PTS system mannose fructose sorbose family IID component
HRD68_19680	COG3715	PTS system
HRD68_19685	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD68_19685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_19690	COG1253	flavin adenine dinucleotide binding
HRD68_19700	COG1760	l-serine dehydratase
HRD68_19705	COG0494	nUDIX hydrolase
HRD68_19715	COG3140	Belongs to the UPF0181 family
HRD68_19720	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HRD68_19725	COG0513	Belongs to the DEAD box helicase family
HRD68_19730	COG3141	response to X-ray
HRD68_19745	COG1770	oligopeptidase
HRD68_19750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD68_19770	COG1528	Iron-storage protein
HRD68_19775	COG2372	response to copper ion
HRD68_19780	COG1276	copper resistance
HRD68_19795	COG0346	lactoylglutathione lyase activity
HRD68_19835	COG0625	glutathione transferase activity
HRD68_19860	COG4251	negative regulation of phosphorylation
HRD68_19860	COG2203	Gaf domain
HRD68_19860	COG3706	GGDEF domain
HRD68_19860	COG5001	Diguanylate cyclase
HRD68_19895	COG2814	Major facilitator Superfamily
HRD68_19905	COG3008	intermembrane lipid transfer
HRD68_19910	COG2995	paraquat-inducible protein a
HRD68_19915	COG1956	GAF domain-containing protein
HRD68_19920	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HRD68_19925	COG0793	Belongs to the peptidase S41A family
HRD68_19930	COG0501	Belongs to the peptidase M48B family
HRD68_19935	COG2814	Major facilitator Superfamily
HRD68_19940	COG0823	Involved in the tonB-independent uptake of proteins
HRD68_19950	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRD68_19960	COG1988	membrane-bound metal-dependent
HRD68_19965	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD68_19975	COG3842	ATPase activity
HRD68_19980	COG0395	ABC-type sugar transport system, permease component
HRD68_19985	COG1175	transmembrane transport
HRD68_19995	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_20000	COG1917	Cupin 2, conserved barrel domain protein
HRD68_20005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD68_20015	COG3001	Fructosamine kinase
HRD68_20020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD68_20025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD68_20030	COG1121	(ABC) transporter
HRD68_20035	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRD68_20060	COG3623	hexulose-6-phosphate isomerase
HRD68_20065	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HRD68_20070	COG1070	Carbohydrate kinase
HRD68_20090	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_20095	COG1129	ABC transporter
HRD68_20100	COG1414	Transcriptional regulator
HRD68_20105	COG1811	Na channel or pump
HRD68_20110	COG4249	Peptidase C14 caspase catalytic subunit p20
HRD68_20155	COG0776	regulation of translation
HRD68_20160	COG2719	SpoVR family
HRD68_20165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD68_20170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRD68_20175	COG0642	Histidine kinase
HRD68_20185	COG3111	PFAM Bacterial OB fold (BOF) protein
HRD68_20190	COG2814	Major facilitator Superfamily
HRD68_20195	COG2199	diguanylate cyclase activity
HRD68_20195	COG2200	EAL domain
HRD68_20195	COG2202	Pas domain
HRD68_20205	COG0583	DNA-binding transcription factor activity
HRD68_20215	COG2718	Belongs to the UPF0229 family
HRD68_20220	COG2766	serine protein kinase
HRD68_20225	COG3713	MltA-interacting MipA family protein
HRD68_20255	COG3139	Protein of unknown function (DUF1315)
HRD68_20260	COG1335	isochorismatase
HRD68_20265	COG0252	asparaginase activity
HRD68_20270	COG0616	signal peptide processing
HRD68_20275	COG0778	Nitroreductase
HRD68_20285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRD68_20295	COG0494	nUDIX hydrolase
HRD68_20300	COG0708	Exodeoxyribonuclease III
HRD68_20305	COG0583	DNA-binding transcription factor activity
HRD68_20325	COG0788	formyltetrahydrofolate deformylase activity
HRD68_20330	COG3012	SEC-C Motif Domain Protein
HRD68_20340	COG1752	Esterase of the alpha-beta hydrolase superfamily
HRD68_20345	COG0745	RESPONSE REGULATOR receiver
HRD68_20355	COG2916	Histone family protein nucleoid-structuring protein H-NS
HRD68_20365	COG1454	alcohol dehydrogenase
HRD68_20365	COG1012	belongs to the aldehyde dehydrogenase family
HRD68_20370	COG2095	MarC family integral membrane protein
HRD68_20375	COG4166	transmembrane transport
HRD68_20390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD68_20395	COG0444	Belongs to the ABC transporter superfamily
HRD68_20400	COG4608	Belongs to the ABC transporter superfamily
HRD68_20405	COG3099	Belongs to the UPF0263 family
HRD68_20410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRD68_20420	COG2200	EAL domain
HRD68_20430	COG2350	Protein conserved in bacteria
HRD68_20435	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HRD68_20445	COG2917	probably involved in intracellular septation
HRD68_20460	COG3047	cAMP biosynthetic process
HRD68_20470	COG0159	tryptophan synthase activity
HRD68_20475	COG0133	tryptophan synthase activity
HRD68_20480	COG0135	phosphoribosylanthranilate isomerase activity
HRD68_20480	COG0134	indole-3-glycerol-phosphate synthase activity
HRD68_20490	COG0512	Glutamine amidotransferase of anthranilate synthase
HRD68_20505	COG0613	PHP domain protein
HRD68_20510	COG0009	L-threonylcarbamoyladenylate synthase
HRD68_20520	COG2197	response regulator
HRD68_20530	COG1187	pseudouridine synthase activity
HRD68_20540	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_20545	COG0616	signal peptide processing
HRD68_20560	COG0583	DNA-binding transcription factor activity
HRD68_20570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRD68_20580	COG0671	phosphoesterase, PA-phosphatase related
HRD68_20585	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HRD68_20590	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HRD68_20605	COG0284	orotidine-5'-phosphate decarboxylase activity
HRD68_20610	COG0023	Translation Initiation Factor
HRD68_20620	COG0235	Class ii aldolase
HRD68_20630	COG1349	DNA-binding transcription factor activity
HRD68_20645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRD68_20650	COG2879	small protein
HRD68_20655	COG1966	Carbon starvation protein
HRD68_20660	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HRD68_20665	COG0243	molybdopterin cofactor binding
HRD68_20670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HRD68_20680	COG4659	FMN binding
HRD68_20690	COG3708	Transcriptional regulator
HRD68_20690	COG2207	Transcriptional regulator
HRD68_20705	COG4657	Part of a membrane complex involved in electron transport
HRD68_20715	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HRD68_20730	COG2274	protein secretion by the type I secretion system
HRD68_20735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRD68_20740	COG2160	L-arabinose isomerase activity
HRD68_20750	COG1879	ABC-type sugar transport system periplasmic component
HRD68_20755	COG1129	ABC transporter
HRD68_20760	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_20770	COG0673	inositol 2-dehydrogenase activity
HRD68_20775	COG0385	Bile acid
HRD68_20780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRD68_20785	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRD68_20790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_20790	COG1263	PTS System
HRD68_20795	COG1609	Transcriptional regulator
HRD68_20815	COG5339	Protein conserved in bacteria
HRD68_20825	COG0114	fumarate hydratase activity
HRD68_20840	COG2814	Major facilitator Superfamily
HRD68_20845	COG0583	DNA-binding transcription factor activity
HRD68_20850	COG1940	carbohydrate kinase activity
HRD68_20855	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HRD68_20875	COG1742	UPF0060 membrane protein
HRD68_20880	COG4221	oxidoreductase activity
HRD68_20885	COG0477	Major facilitator Superfamily
HRD68_20910	COG2211	Major facilitator Superfamily
HRD68_20925	COG0625	glutathione transferase activity
HRD68_20935	COG1522	sequence-specific DNA binding
HRD68_20960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRD68_20985	COG0076	glutamate decarboxylase activity
HRD68_20990	COG0531	amino acid
HRD68_21000	COG1011	Hydrolase
HRD68_21025	COG1028	Short-chain dehydrogenase reductase Sdr
HRD68_21035	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HRD68_21050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRD68_21055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD68_21060	COG0589	response to stress
HRD68_21065	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HRD68_21070	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HRD68_21080	COG0531	amino acid
HRD68_21090	COG0745	RESPONSE REGULATOR receiver
HRD68_21095	COG2205	protein histidine kinase activity
HRD68_21100	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HRD68_21110	COG3591	Belongs to the peptidase S1B family
HRD68_21120	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HRD68_21125	COG1643	Atp-dependent helicase
HRD68_21130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRD68_21135	COG0477	Major facilitator Superfamily
HRD68_21145	COG3423	Transcriptional regulator
HRD68_21155	COG0246	Mannitol dehydrogenase
HRD68_21160	COG1070	Carbohydrate kinase
HRD68_21170	COG3784	Protein of unknown function (DUF1318)
HRD68_21180	COG2911	Protein conserved in bacteria
HRD68_21185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRD68_21190	COG3042	response to heat
HRD68_21200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRD68_21200	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRD68_21200	COG1013	pyruvate-flavodoxin oxidoreductase activity
HRD68_21200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD68_21205	COG2723	6-phospho-beta-galactosidase activity
HRD68_21210	COG2190	(PTS) system
HRD68_21210	COG1263	PTS System
HRD68_21210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_21215	COG3711	transcriptional antiterminator
HRD68_21220	COG0037	tRNA processing
HRD68_21230	COG4166	transmembrane transport
HRD68_21235	COG2866	Carboxypeptidase
HRD68_21240	COG4948	Mandelate Racemase Muconate Lactonizing
HRD68_21245	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HRD68_21255	COG5642	Protein of unknown function (DUF2384)
HRD68_21260	COG5654	RES domain protein
HRD68_21265	COG3768	UPF0283 membrane protein
HRD68_21270	COG3106	COG3106 Predicted ATPase
HRD68_21280	COG1983	PspC domain protein
HRD68_21290	COG1842	Phage shock protein A
HRD68_21295	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HRD68_21300	COG4166	transmembrane transport
HRD68_21310	COG4171	peptide transport system, permease
HRD68_21320	COG4172	Belongs to the ABC transporter superfamily
HRD68_21325	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD68_21325	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD68_21330	COG3104	oligopeptide transport
HRD68_21335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD68_21355	COG0625	glutathione transferase activity
HRD68_21365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRD68_21375	COG3895	Periplasmic Protein
HRD68_21380	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HRD68_21385	COG3133	Outer membrane lipoprotein
HRD68_21390	COG1846	Transcriptional regulator
HRD68_21400	COG1566	PFAM secretion protein HlyD family protein
HRD68_21410	COG4989	oxidoreductase activity
HRD68_21415	COG3313	Fe-S protein
HRD68_21420	COG2194	sulfuric ester hydrolase activity
HRD68_21425	COG1309	transcriptional regulator
HRD68_21430	COG1902	pentaerythritol trinitrate reductase activity
HRD68_21435	COG0346	lactoylglutathione lyase activity
HRD68_21440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD68_21445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HRD68_21450	COG0791	NLP P60 protein
HRD68_21465	COG1609	Transcriptional regulator
HRD68_21470	COG0583	DNA-binding transcription factor activity
HRD68_21475	COG2814	Major facilitator Superfamily
HRD68_21480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRD68_21485	COG0307	riboflavin synthase, alpha
HRD68_21490	COG0534	Mate efflux family protein
HRD68_21515	COG1388	LysM domain
HRD68_21515	COG1376	ErfK ybiS ycfS ynhG family protein
HRD68_21520	COG2166	iron-sulfur cluster assembly
HRD68_21530	COG0719	Fe-S assembly protein
HRD68_21535	COG0396	ATPase activity
HRD68_21540	COG0719	Fe-S assembly protein
HRD68_21545	COG0316	Belongs to the HesB IscA family
HRD68_21550	COG2050	protein possibly involved in aromatic compounds catabolism
HRD68_21555	COG0247	lactate metabolic process
HRD68_21555	COG0277	FAD linked oxidase domain protein
HRD68_21560	COG0628	permease
HRD68_21570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD68_21570	COG0574	Belongs to the PEP-utilizing enzyme family
HRD68_21575	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HRD68_21590	COG0095	Lipoate-protein ligase
HRD68_21595	COG0791	NLP P60 protein
HRD68_21600	COG2076	Multidrug Resistance protein
HRD68_21610	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRD68_21615	COG0726	polysaccharide deacetylase
HRD68_21625	COG0463	Glycosyl transferase, family 2
HRD68_21630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD68_21635	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HRD68_21640	COG0386	Belongs to the glutathione peroxidase family
HRD68_21645	COG4139	cobalamin transport
HRD68_21655	COG0791	NLP P60 protein
HRD68_21660	COG2186	Transcriptional regulator
HRD68_21665	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRD68_21670	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HRD68_21680	COG2983	Belongs to the UPF0260 family
HRD68_21685	COG0179	Fumarylacetoacetate (FAA) hydrolase
HRD68_21690	COG3100	YcgL domain-containing protein
HRD68_21695	COG0850	regulation of cytokinetic process
HRD68_21700	COG2894	cell division
HRD68_21705	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HRD68_21710	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRD68_21715	COG0318	PFAM AMP-dependent synthetase and ligase
HRD68_21720	COG3065	identical protein binding
HRD68_21730	COG1199	ATP-dependent helicase activity
HRD68_21735	COG0251	oxidation-reduction process
HRD68_21740	COG2076	Multidrug Resistance protein
HRD68_21745	COG2076	Multidrug Resistance protein
HRD68_21750	COG3397	chitin binding
HRD68_21755	COG0800	Aldolase
HRD68_21760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRD68_21765	COG1737	Transcriptional regulator
HRD68_21770	COG0469	pyruvate kinase activity
HRD68_21775	COG1560	Kdo2-lipid A biosynthetic process
HRD68_21780	COG0739	heme binding
HRD68_21785	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HRD68_21790	COG1121	(ABC) transporter
HRD68_21795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD68_21800	COG2255	four-way junction helicase activity
HRD68_21805	COG0632	four-way junction helicase activity
HRD68_21815	COG0217	transcriptional regulatory protein
HRD68_21820	COG0494	nUDIX hydrolase
HRD68_21825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRD68_21830	COG1335	isochorismatase
HRD68_21835	COG1801	Protein of unknown function DUF72
HRD68_21840	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HRD68_21850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD68_21855	COG3142	Participates in the control of copper homeostasis
HRD68_21860	COG3102	Protein conserved in bacteria
HRD68_21870	COG0728	peptidoglycan biosynthetic process
HRD68_21875	COG0673	inositol 2-dehydrogenase activity
HRD68_21885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD68_21890	COG0477	Major facilitator Superfamily
HRD68_21900	COG3381	protein complex oligomerization
HRD68_21910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD68_21925	COG3706	GGDEF domain
HRD68_21930	COG0659	secondary active sulfate transmembrane transporter activity
HRD68_21950	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD68_21955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRD68_21960	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HRD68_21965	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HRD68_21975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRD68_21985	COG0193	aminoacyl-tRNA hydrolase activity
HRD68_21995	COG0012	GTP binding
HRD68_22000	COG0582	viral genome integration into host DNA
HRD68_22045	COG4974	Belongs to the 'phage' integrase family
HRD68_22050	COG2003	Belongs to the UPF0758 family
HRD68_22070	COG3423	Transcriptional regulator
HRD68_22130	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HRD68_22135	COG2831	hemolysin activation secretion protein
HRD68_22140	COG3210	domain, Protein
HRD68_22185	COG0786	glutamate:sodium symporter activity
HRD68_22190	COG0288	reversible hydration of carbon dioxide
HRD68_22220	COG0667	Aldo Keto reductase
HRD68_22225	COG0318	PFAM AMP-dependent synthetase and ligase
HRD68_22230	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HRD68_22235	COG0644	oxidoreductase
HRD68_22240	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HRD68_22245	COG2086	electron transfer activity
HRD68_22250	COG2207	Transcriptional regulator
HRD68_22250	COG1917	Cupin 2, conserved barrel domain protein
HRD68_22255	COG1960	acyl-CoA dehydrogenase activity
HRD68_22260	COG4670	ketone body catabolic process
HRD68_22275	COG2271	Major facilitator Superfamily
HRD68_22280	COG0583	DNA-binding transcription factor activity
HRD68_22285	COG0738	Major facilitator superfamily
HRD68_22295	COG4942	peptidase
HRD68_22305	COG3443	Belongs to the bacterial solute-binding protein 9 family
HRD68_22310	COG4211	Belongs to the binding-protein-dependent transport system permease family
HRD68_22315	COG1129	ABC transporter
HRD68_22330	COG0402	S-adenosylhomocysteine deaminase activity
HRD68_22340	COG1228	amidohydrolase
HRD68_22355	COG2988	succinylglutamate desuccinylase activity
HRD68_22360	COG3724	N-succinylarginine dihydrolase activity
HRD68_22370	COG3138	arginine N-succinyltransferase
HRD68_22375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRD68_22380	COG3866	Pectate lyase
HRD68_22385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD68_22390	COG1271	oxidase subunit
HRD68_22395	COG1294	oxidase, subunit
HRD68_22405	COG3850	Histidine kinase
HRD68_22420	COG0387	Pfam Sodium calcium exchanger
HRD68_22425	COG1702	phosphate starvation-inducible protein PhoH
HRD68_22435	COG3658	cytochrome
HRD68_22440	COG1215	transferase activity, transferring glycosyl groups
HRD68_22445	COG1649	PFAM Uncharacterised BCR, COG1649
HRD68_22445	COG0726	polysaccharide deacetylase
HRD68_22450	COG0457	Tetratricopeptide repeat
HRD68_22455	COG0006	proline dipeptidase activity
HRD68_22485	COG0577	efflux transmembrane transporter activity
HRD68_22485	COG1136	(ABC) transporter
HRD68_22495	COG0577	efflux transmembrane transporter activity
HRD68_22495	COG1136	(ABC) transporter
HRD68_22510	COG0672	)-iron permease
HRD68_22520	COG1447	Phosphotransferase system cellobiose-specific component IIA
HRD68_22525	COG2723	6-phospho-beta-galactosidase activity
HRD68_22530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD68_22530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD68_22535	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD68_22540	COG1609	Transcriptional regulator
HRD68_22555	COG2066	Belongs to the glutaminase family
HRD68_22560	COG3290	protein histidine kinase activity
HRD68_22565	COG4565	transcriptional regulatory protein
HRD68_22570	COG3493	citrate carrier protein
HRD68_22580	COG3189	MarR family transcriptional regulator
HRD68_22590	COG2223	nitrite transmembrane transporter activity
HRD68_22595	COG0561	phosphatase activity
HRD68_22615	COG0538	isocitrate dehydrogenase activity
HRD68_22620	COG1187	pseudouridine synthase activity
HRD68_22630	COG0482	sulfurtransferase activity
HRD68_22635	COG2915	High frequency lysogenization protein hflD homolog
HRD68_22640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRD68_22650	COG0745	RESPONSE REGULATOR receiver
HRD68_22655	COG2205	protein histidine kinase activity
HRD68_22660	COG2850	peptidyl-arginine hydroxylation
HRD68_22675	COG1940	carbohydrate kinase activity
HRD68_22680	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRD68_22690	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRD68_22695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HRD68_22700	COG3134	Outer membrane lipoprotein
HRD68_22705	COG1252	NADH dehydrogenase
HRD68_22710	COG3150	esterase
HRD68_22725	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HRD68_22730	COG5633	Lipoprotein
HRD68_22735	COG0537	adenosine 5'-monophosphoramidase activity
HRD68_22740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRD68_22750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_22750	COG1263	PTS System
HRD68_22755	COG0084	hydrolase, TatD family'
HRD68_22760	COG0470	DNA polymerase III
HRD68_22765	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRD68_22770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRD68_22775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRD68_22780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD68_22805	COG0416	fatty acid biosynthetic process
HRD68_22810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRD68_22815	COG1399	metal-binding, possibly nucleic acid-binding protein
HRD68_22825	COG0564	pseudouridine synthase activity
HRD68_22830	COG1530	ribonuclease E activity
HRD68_22835	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HRD68_22840	COG0418	dihydroorotase activity
HRD68_22860	COG2197	response regulator
HRD68_22870	COG0628	permease
HRD68_22880	COG0697	spore germination
HRD68_22915	COG1560	Kdo2-lipid A biosynthetic process
HRD68_22920	COG2259	Doxx family
HRD68_22925	COG2814	Major facilitator Superfamily
HRD68_22930	COG3104	oligopeptide transport
HRD68_22940	COG5645	(Lipo)protein
HRD68_22945	COG2943	transferase activity, transferring hexosyl groups
HRD68_22950	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HRD68_22965	COG3263	regulation of cellular component size
HRD68_22975	COG3916	Acyl-homoserine-lactone synthase
HRD68_22980	COG2771	luxR family
HRD68_22985	COG3088	subunit of a heme lyase
HRD68_22985	COG4235	cytochrome complex assembly
HRD68_22990	COG3088	subunit of a heme lyase
HRD68_22995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD68_23000	COG1138	Cytochrome C-type biogenesis protein
HRD68_23005	COG3301	Polysulphide reductase, NrfD
HRD68_23010	COG0437	4 iron, 4 sulfur cluster binding
HRD68_23015	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HRD68_23040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRD68_23045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRD68_23050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD68_23050	COG1263	PTS System
HRD68_23060	COG0698	ribose 5-phosphate isomerase
HRD68_23065	COG1737	Transcriptional regulator
HRD68_23070	COG1879	ABC-type sugar transport system periplasmic component
HRD68_23075	COG1129	ABC transporter
HRD68_23080	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD68_23085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRD68_23090	COG1940	carbohydrate kinase activity
HRD68_23095	COG1349	DNA-binding transcription factor activity
HRD68_23105	COG0738	Major facilitator superfamily
HRD68_23140	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1