locus-tag	class	description
HRD69_00015	COG0804	urea catabolic process
HRD69_00025	COG0831	urea catabolic process
HRD69_00040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD69_00045	COG0601	transmembrane transport
HRD69_00050	COG0747	negative chemotaxis
HRD69_00055	COG1278	Cold shock
HRD69_00080	COG4575	ribosome binding
HRD69_00090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD69_00095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRD69_00100	COG1780	Probably involved in ribonucleotide reductase function
HRD69_00105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD69_00110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD69_00115	COG4175	Glycine betaine
HRD69_00125	COG2113	Glycine betaine
HRD69_00160	COG3210	domain, Protein
HRD69_00165	COG2831	hemolysin activation secretion protein
HRD69_00175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD69_00180	COG0328	RNA-DNA hybrid ribonuclease activity
HRD69_00185	COG2226	methyltransferase
HRD69_00190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD69_00195	COG1388	LysM domain
HRD69_00195	COG0741	lytic transglycosylase activity
HRD69_00200	COG3021	interspecies interaction between organisms
HRD69_00205	COG0656	L-ascorbic acid biosynthetic process
HRD69_00210	COG0583	DNA-binding transcription factor activity
HRD69_00215	COG2814	Major facilitator Superfamily
HRD69_00240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HRD69_00250	COG2011	ABC-type metal ion transport system permease component
HRD69_00255	COG1464	Belongs to the NlpA lipoprotein family
HRD69_00265	COG1720	tRNA m6t6A37 methyltransferase activity
HRD69_00275	COG3015	lipoprotein NlpE involved in copper resistance
HRD69_00285	COG4681	YaeQ
HRD69_00295	COG4568	rho-dependent transcription termination
HRD69_00310	COG0346	lactoylglutathione lyase activity
HRD69_00325	COG0825	malonyl-CoA metabolic process
HRD69_00330	COG0587	DNA-directed DNA polymerase activity
HRD69_00335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRD69_00345	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD69_00355	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD69_00360	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HRD69_00370	COG0750	zinc metalloprotease
HRD69_00375	COG0575	Belongs to the CDS family
HRD69_00385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRD69_00390	COG0233	cytoplasmic translational termination
HRD69_00395	COG0528	UMP kinase activity
HRD69_00400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRD69_00405	COG0052	Belongs to the universal ribosomal protein uS2 family
HRD69_00415	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HRD69_00420	COG2171	N-acyltransferase activity
HRD69_00440	COG0564	pseudouridine synthase activity
HRD69_00445	COG3098	single-species biofilm formation
HRD69_00455	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRD69_00455	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRD69_00460	COG1611	Belongs to the LOG family
HRD69_00470	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HRD69_00475	COG2363	Small membrane protein
HRD69_00480	COG0583	DNA-binding transcription factor activity
HRD69_00490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRD69_00495	COG2166	iron-sulfur cluster assembly
HRD69_00500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HRD69_00505	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HRD69_00525	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRD69_00530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HRD69_00530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRD69_00535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRD69_00540	COG1074	ATP-dependent DNA helicase activity
HRD69_00545	COG1025	Belongs to the peptidase M16 family
HRD69_00550	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HRD69_00565	COG4795	General secretion pathway protein
HRD69_00580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRD69_00590	COG1051	belongs to the nudix hydrolase family
HRD69_00600	COG0861	Integral membrane protein TerC family
HRD69_00605	COG0667	Aldo Keto reductase
HRD69_00610	COG0477	Major facilitator Superfamily
HRD69_00615	COG0318	PFAM AMP-dependent synthetase and ligase
HRD69_00615	COG0204	Acyl-transferase
HRD69_00625	COG1609	Transcriptional regulator
HRD69_00635	COG0583	DNA-binding transcription factor activity
HRD69_00640	COG2814	Major facilitator Superfamily
HRD69_00645	COG0583	DNA-binding transcription factor activity
HRD69_00660	COG0840	transmembrane signaling receptor activity
HRD69_00685	COG0288	reversible hydration of carbon dioxide
HRD69_00690	COG1733	regulation of RNA biosynthetic process
HRD69_00695	COG1028	Short-chain dehydrogenase reductase Sdr
HRD69_00705	COG0484	heat shock protein binding
HRD69_00715	COG2271	Major facilitator Superfamily
HRD69_00730	COG3706	GGDEF domain
HRD69_00740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRD69_00750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRD69_00755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRD69_00760	COG4974	Belongs to the 'phage' integrase family
HRD69_00765	COG0716	FMN binding
HRD69_00770	COG4452	Inner membrane protein CreD
HRD69_00775	COG2205	protein histidine kinase activity
HRD69_00780	COG0745	RESPONSE REGULATOR receiver
HRD69_00795	COG0354	folic acid binding
HRD69_00800	COG1272	protein, Hemolysin III
HRD69_00805	COG1028	Short-chain dehydrogenase reductase Sdr
HRD69_00810	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRD69_00810	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRD69_00815	COG0509	glycine decarboxylation via glycine cleavage system
HRD69_00820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRD69_00825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD69_00830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD69_00835	COG0006	proline dipeptidase activity
HRD69_00840	COG3079	Belongs to the UPF0149 family
HRD69_00845	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HRD69_00855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRD69_00860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD69_00865	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HRD69_00870	COG0583	DNA-binding transcription factor activity
HRD69_00880	COG1279	arginine transmembrane transporter activity
HRD69_00890	COG0191	fructose-bisphosphate aldolase activity
HRD69_00895	COG0126	phosphoglycerate kinase activity
HRD69_00900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRD69_00905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRD69_00910	COG0501	Belongs to the peptidase M48B family
HRD69_00920	COG1166	arginine decarboxylase activity
HRD69_00925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRD69_00940	COG0640	Transcriptional regulator
HRD69_00945	COG3091	SprT-like family
HRD69_00950	COG2356	endonuclease I
HRD69_00955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRD69_00960	COG0189	ligase activity
HRD69_00965	COG1678	Uncharacterized ACR, COG1678
HRD69_00970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRD69_00975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD69_00985	COG2805	Type II/IV secretion system protein
HRD69_00990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRD69_00995	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRD69_01000	COG0762	integral membrane protein
HRD69_01005	COG1872	DUF167
HRD69_01010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRD69_01015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRD69_01025	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HRD69_01025	COG3064	Membrane
HRD69_01025	COG1073	alpha beta
HRD69_01040	COG3171	Protein conserved in bacteria
HRD69_01045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRD69_01050	COG1194	a g-specific adenine glycosylase
HRD69_01060	COG0741	lytic transglycosylase activity
HRD69_01065	COG1982	Orn Lys Arg decarboxylase major
HRD69_01240	COG2885	chlorophyll binding
HRD69_01240	COG3047	cAMP biosynthetic process
HRD69_01270	COG2979	Protein of unknown function (DUF533)
HRD69_01335	COG3596	GTP binding
HRD69_01380	COG0436	Aminotransferase
HRD69_01390	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HRD69_01460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRD69_01470	COG0024	Methionine aminopeptidase
HRD69_01475	COG4604	ABC transporter, ATP-binding protein
HRD69_01480	COG4605	iron ion homeostasis
HRD69_01490	COG4607	ABC-type enterochelin transport system periplasmic component
HRD69_01495	COG0477	Major facilitator Superfamily
HRD69_01500	COG1609	Transcriptional regulator
HRD69_01510	COG1283	sodium-dependent phosphate transmembrane transporter activity
HRD69_01525	COG0477	Major facilitator Superfamily
HRD69_01530	COG4302	ethanolamine ammonia-lyase activity
HRD69_01535	COG4303	Ethanolamine ammonia lyase large subunit
HRD69_01555	COG5001	Diguanylate cyclase
HRD69_01565	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HRD69_01570	COG0309	Hydrogenase expression formation protein (HypE)
HRD69_01575	COG0409	Hydrogenase expression formation protein
HRD69_01580	COG0298	carbon dioxide binding
HRD69_01585	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRD69_01595	COG1773	rubredoxin
HRD69_01600	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HRD69_01605	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HRD69_01610	COG5557	Pfam Polysulphide reductase, NrfD
HRD69_01615	COG0437	4 iron, 4 sulfur cluster binding
HRD69_01620	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HRD69_01635	COG3133	Outer membrane lipoprotein
HRD69_01655	COG0840	transmembrane signaling receptor activity
HRD69_01660	COG4178	(ABC) transporter
HRD69_01665	COG0612	Peptidase, M16
HRD69_01670	COG4771	TonB-dependent receptor
HRD69_01680	COG1595	DNA-templated transcription, initiation
HRD69_01685	COG4592	Periplasmic binding protein
HRD69_01690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD69_01695	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD69_01700	COG1120	ATPase activity
HRD69_01725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD69_01730	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD69_01755	COG4964	Belongs to the GSP D family
HRD69_01800	COG0848	biopolymer transport protein
HRD69_01815	COG0586	Pfam SNARE associated Golgi protein
HRD69_01820	COG2207	Transcriptional regulator
HRD69_01825	COG1979	alcohol dehydrogenase
HRD69_01830	COG0656	L-ascorbic acid biosynthetic process
HRD69_01840	COG2132	Multicopper oxidase
HRD69_01845	COG0204	Acyl-transferase
HRD69_01850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRD69_01855	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRD69_01860	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HRD69_01875	COG3150	esterase
HRD69_01880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HRD69_01885	COG3151	Protein conserved in bacteria
HRD69_01890	COG0494	nUDIX hydrolase
HRD69_01895	COG1538	Outer membrane efflux protein
HRD69_01905	COG0754	glutathionylspermidine amidase activity
HRD69_01910	COG3384	dioxygenase
HRD69_01915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRD69_01925	COG0531	amino acid
HRD69_01930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRD69_01930	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HRD69_01935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HRD69_01940	COG3025	triphosphatase activity
HRD69_01945	COG4991	sh3 domain protein
HRD69_01950	COG0617	tRNA 3'-terminal CCA addition
HRD69_01955	COG1968	undecaprenyl-diphosphatase activity
HRD69_01960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HRD69_01965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HRD69_01970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRD69_01975	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRD69_01980	COG0358	DNA primase activity
HRD69_02025	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRD69_02035	COG1580	Controls the rotational direction of flagella during chemotaxis
HRD69_02040	COG3144	bacterial-type flagellum assembly
HRD69_02050	COG1157	protein secretion by the type III secretion system
HRD69_02065	COG1766	The M ring may be actively involved in energy transduction
HRD69_02070	COG1677	Flagellar hook-basal body complex protein FliE
HRD69_02075	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HRD69_02080	COG2201	protein-glutamate methylesterase activity
HRD69_02085	COG0745	RESPONSE REGULATOR receiver
HRD69_02090	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HRD69_02095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD69_02100	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD69_02135	COG0840	transmembrane signaling receptor activity
HRD69_02140	COG0835	chemotaxis
HRD69_02145	COG2198	Histidine kinase
HRD69_02145	COG0643	Histidine kinase
HRD69_02150	COG1360	Flagellar Motor Protein
HRD69_02175	COG0840	transmembrane signaling receptor activity
HRD69_02180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRD69_02190	COG1705	Flagellar rod assembly protein muramidase FlgJ
HRD69_02190	COG3951	Flagellar rod assembly protein muramidase FlgJ
HRD69_02195	COG1706	bacterial-type flagellum-dependent cell motility
HRD69_02230	COG1815	bacterial-type flagellum-dependent cell motility
HRD69_02235	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HRD69_02250	COG3247	response to pH
HRD69_02255	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRD69_02255	COG1902	pentaerythritol trinitrate reductase activity
HRD69_02290	COG0583	DNA-binding transcription factor activity
HRD69_02300	COG2813	Specifically methylates the guanine in position
HRD69_02310	COG1451	nucleotide metabolic process
HRD69_02315	COG0673	inositol 2-dehydrogenase activity
HRD69_02320	COG0861	Integral membrane protein TerC family
HRD69_02325	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HRD69_02335	COG2721	sulfolactate sulfo-lyase activity
HRD69_02345	COG1904	glucuronate isomerase
HRD69_02350	COG2271	Major facilitator Superfamily
HRD69_02365	COG0586	Pfam SNARE associated Golgi protein
HRD69_02380	COG4575	ribosome binding
HRD69_02385	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HRD69_02395	COG2259	Doxx family
HRD69_02400	COG0583	DNA-binding transcription factor activity
HRD69_02405	COG1741	Belongs to the pirin family
HRD69_02410	COG1064	alcohol dehydrogenase
HRD69_02430	COG1834	amidinotransferase
HRD69_02435	COG0574	Belongs to the PEP-utilizing enzyme family
HRD69_02435	COG3848	Pyruvate phosphate dikinase
HRD69_02440	COG4521	taurine ABC transporter
HRD69_02450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRD69_02465	COG3424	synthase
HRD69_02505	COG3188	usher protein
HRD69_02515	COG3539	Fimbrial protein
HRD69_02525	COG2200	EAL domain
HRD69_02540	COG3121	Chaperone
HRD69_02545	COG3188	usher protein
HRD69_02560	COG2963	transposase activity
HRD69_02565	COG2197	response regulator
HRD69_02570	COG2205	protein histidine kinase activity
HRD69_02570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD69_02585	COG3188	usher protein
HRD69_02675	COG3501	Rhs element vgr protein
HRD69_02745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRD69_02755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRD69_02790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRD69_02800	COG0792	nuclease activity
HRD69_02805	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HRD69_02810	COG2823	Periplasmic or secreted lipoprotein
HRD69_02815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD69_02820	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HRD69_02825	COG5002	protein histidine kinase activity
HRD69_02825	COG2198	Histidine kinase
HRD69_02825	COG0784	Response regulator, receiver
HRD69_02830	COG1242	4 iron, 4 sulfur cluster binding
HRD69_02835	COG0067	glutamate synthase
HRD69_02835	COG0069	glutamate synthase activity
HRD69_02835	COG0070	glutamate synthase
HRD69_02840	COG0493	'glutamate synthase
HRD69_02850	COG2969	positive regulation of protein catabolic process
HRD69_02855	COG0625	glutathione transferase activity
HRD69_02860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRD69_02865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRD69_02870	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HRD69_02875	COG3105	Protein conserved in bacteria
HRD69_02880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD69_02885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD69_02895	COG5007	Belongs to the BolA IbaG family
HRD69_02900	COG3113	response to antibiotic
HRD69_02905	COG2854	intermembrane phospholipid transfer
HRD69_02910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRD69_02915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRD69_02920	COG1127	ABC transporter
HRD69_02925	COG0530	calcium, potassium:sodium antiporter activity
HRD69_02930	COG0517	IMP dehydrogenase activity
HRD69_02930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HRD69_02935	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HRD69_02940	COG3117	lipopolysaccharide transmembrane transporter activity
HRD69_02945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HRD69_02950	COG1137	ATPase activity
HRD69_02955	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HRD69_02970	COG1660	Displays ATPase and GTPase activities
HRD69_02975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD69_02980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRD69_02985	COG0679	Auxin Efflux Carrier
HRD69_02990	COG0540	Belongs to the ATCase OTCase family
HRD69_02995	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HRD69_03005	COG2308	Evidence 4 Homologs of previously reported genes of
HRD69_03040	COG1609	Transcriptional regulator
HRD69_03045	COG1263	PTS System
HRD69_03045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD69_03050	COG0366	Alpha amylase catalytic
HRD69_03055	COG3711	transcriptional antiterminator
HRD69_03055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD69_03070	COG3964	amidohydrolase
HRD69_03100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRD69_03105	COG3783	Cytochrome b(562)
HRD69_03115	COG0312	modulator of DNA gyrase
HRD69_03120	COG3028	Belongs to the UPF0307 family
HRD69_03125	COG2732	(Barnase) inhibitor
HRD69_03135	COG1012	belongs to the aldehyde dehydrogenase family
HRD69_03140	COG1289	transmembrane transporter activity
HRD69_03145	COG1566	PFAM secretion protein HlyD family protein
HRD69_03155	COG0583	DNA-binding transcription factor activity
HRD69_03200	COG0312	modulator of DNA gyrase
HRD69_03205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD69_03210	COG3164	Protein of unknown function
HRD69_03215	COG1530	ribonuclease E activity
HRD69_03220	COG0424	maF-like protein
HRD69_03225	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HRD69_03230	COG1792	Involved in formation and maintenance of cell shape
HRD69_03235	COG1077	Cell shape determining protein MreB Mrl
HRD69_03240	COG2200	EAL domain
HRD69_03240	COG2199	diguanylate cyclase activity
HRD69_03245	COG0604	alcohol dehydrogenase
HRD69_03255	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HRD69_03260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HRD69_03265	COG0511	ligase activity, forming carbon-carbon bonds
HRD69_03270	COG0439	Biotin carboxylase
HRD69_03275	COG3924	membrane
HRD69_03280	COG4145	pantothenate transmembrane transporter activity
HRD69_03285	COG2264	protein methyltransferase activity
HRD69_03290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD69_03295	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HRD69_03305	COG3133	Outer membrane lipoprotein
HRD69_03310	COG1278	Cold shock
HRD69_03315	COG1278	Cold shock
HRD69_03320	COG0471	metal ion transport
HRD69_03330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD69_03340	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD69_03345	COG1129	ABC transporter
HRD69_03355	COG1560	Kdo2-lipid A biosynthetic process
HRD69_03360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD69_03365	COG4597	amino acid ABC transporter
HRD69_03370	COG0765	amino acid transport
HRD69_03375	COG1126	abc transporter atp-binding protein
HRD69_03395	COG1380	Effector of murein hydrolase LrgA
HRD69_03400	COG0583	DNA-binding transcription factor activity
HRD69_03405	COG0025	NhaP-type Na H and K H
HRD69_03410	COG2252	PERMEase
HRD69_03420	COG0629	single-stranded DNA binding
HRD69_03425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRD69_03430	COG2315	Protein conserved in bacteria
HRD69_03435	COG1448	Aminotransferase
HRD69_03465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD69_03470	COG0735	belongs to the Fur family
HRD69_03475	COG3237	CsbD-like
HRD69_03480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRD69_03485	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HRD69_03490	COG2937	Belongs to the GPAT DAPAT family
HRD69_03500	COG3161	chorismate lyase activity
HRD69_03525	COG1175	transmembrane transport
HRD69_03530	COG3833	ABC-type maltose transport systems, permease component
HRD69_03535	COG3223	Belongs to the PsiE family
HRD69_03545	COG0527	aspartate kinase activity
HRD69_03560	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HRD69_03565	COG2224	Isocitrate lyase
HRD69_03570	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HRD69_03575	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HRD69_03620	COG0151	Belongs to the GarS family
HRD69_03640	COG1515	deoxyribonuclease V activity
HRD69_03645	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HRD69_03650	COG2816	NAD+ diphosphatase activity
HRD69_03655	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HRD69_03670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRD69_03675	COG2104	thiamine diphosphate biosynthetic process
HRD69_03680	COG2022	thiamine diphosphate biosynthetic process
HRD69_03685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRD69_03690	COG0823	Involved in the tonB-independent uptake of proteins
HRD69_03700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRD69_03705	COG0085	RNA polymerase activity
HRD69_03710	COG0222	ribosome binding
HRD69_03715	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRD69_03720	COG0081	regulation of translation
HRD69_03725	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRD69_03730	COG0250	Participates in transcription elongation, termination and antitermination
HRD69_03740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRD69_03775	COG1072	(Pantothenic acid kinase))
HRD69_03815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRD69_03820	COG1739	Uncharacterized protein family UPF0029
HRD69_03830	COG1024	Enoyl-CoA hydratase
HRD69_03830	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD69_03835	COG0183	Belongs to the thiolase family
HRD69_03845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HRD69_03865	COG0805	protein transport
HRD69_03870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD69_03875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD69_03880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRD69_03890	COG2226	methyltransferase
HRD69_03895	COG1322	Protein conserved in bacteria
HRD69_03900	COG0586	Pfam SNARE associated Golgi protein
HRD69_03905	COG1966	Carbon starvation protein
HRD69_03920	COG0412	Dienelactone hydrolase
HRD69_03925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HRD69_03930	COG0583	DNA-binding transcription factor activity
HRD69_03935	COG0697	spore germination
HRD69_03940	COG0679	Auxin Efflux Carrier
HRD69_03945	COG0584	glycerophosphoryl diester phosphodiesterase
HRD69_03950	COG3842	ATPase activity
HRD69_03955	COG0395	ABC-type sugar transport system, permease component
HRD69_03960	COG1175	transmembrane transport
HRD69_03965	COG1653	transport
HRD69_04015	COG0410	ABC transporter
HRD69_04025	COG4177	L-phenylalanine transmembrane transporter activity
HRD69_04035	COG0683	leucine binding
HRD69_04040	COG0456	acetyltransferase
HRD69_04050	COG2177	Part of the ABC transporter FtsEX involved in
HRD69_04055	COG2884	Cell division ATP-binding protein ftsE
HRD69_04060	COG0552	protein localization to endoplasmic reticulum
HRD69_04060	COG0552	protein localization to endoplasmic reticulum
HRD69_04065	COG0742	ribosomal rna small subunit methyltransferase
HRD69_04070	COG3776	membrane
HRD69_04085	COG3714	YhhN family
HRD69_04100	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HRD69_04110	COG0247	lactate metabolic process
HRD69_04120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRD69_04125	COG2271	Major facilitator Superfamily
HRD69_04130	COG0584	glycerophosphoryl diester phosphodiesterase
HRD69_04135	COG0561	phosphatase activity
HRD69_04140	COG2267	carboxylic ester hydrolase activity
HRD69_04145	COG1280	lysine exporter protein (LysE YggA)
HRD69_04150	COG1280	lysine exporter protein (LysE YggA)
HRD69_04155	COG0514	ATP-dependent DNA helicase (RecQ)
HRD69_04160	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HRD69_04165	COG2050	protein possibly involved in aromatic compounds catabolism
HRD69_04185	COG5564	TIM-barrel signal transduction protein
HRD69_04190	COG5441	Belongs to the UPF0261 family
HRD69_04200	COG0210	DNA helicase
HRD69_04205	COG1011	Hydrolase
HRD69_04210	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HRD69_04215	COG3159	Protein conserved in bacteria
HRD69_04220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRD69_04225	COG5567	small periplasmic lipoprotein
HRD69_04230	COG1965	Belongs to the frataxin family
HRD69_04235	COG3072	Adenylate cyclase
HRD69_04240	COG0181	hydroxymethylbilane synthase activity
HRD69_04245	COG1587	Uroporphyrinogen-III synthase
HRD69_04250	COG2959	enzyme of heme biosynthesis
HRD69_04255	COG3071	HemY protein
HRD69_04295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD69_04300	COG2244	polysaccharide biosynthetic process
HRD69_04305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD69_04310	COG0456	acetyltransferase
HRD69_04315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HRD69_04320	COG1088	dTDP-glucose 4,6-dehydratase activity
HRD69_04325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HRD69_04330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HRD69_04335	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HRD69_04340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRD69_04345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HRD69_04350	COG3118	belongs to the thioredoxin family
HRD69_04360	COG0248	Ppx GppA phosphatase
HRD69_04400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRD69_04410	COG3121	Chaperone
HRD69_04425	COG3121	Chaperone
HRD69_04480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRD69_04485	COG0583	DNA-binding transcription factor activity
HRD69_04495	COG2337	Toxic component of a toxin-antitoxin (TA) module
HRD69_04500	COG2336	PFAM SpoVT AbrB
HRD69_04530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRD69_04535	COG0129	dihydroxy-acid dehydratase activity
HRD69_04540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRD69_04545	COG3978	acetolactate synthase activity
HRD69_04565	COG3085	chromosome segregation
HRD69_04570	COG0583	DNA-binding transcription factor activity
HRD69_04575	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD69_04580	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD69_04585	COG1129	ABC transporter
HRD69_04590	COG1879	ABC-type sugar transport system periplasmic component
HRD69_04630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRD69_04640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRD69_04655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD69_04665	COG0678	peroxiredoxin activity
HRD69_04665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRD69_04670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD69_04730	COG0165	Argininosuccinate lyase
HRD69_04760	COG2814	Major facilitator Superfamily
HRD69_04765	COG1494	fructose-1,6-bisphosphatase
HRD69_04770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD69_04775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRD69_04780	COG3074	FtsZ-dependent cytokinesis
HRD69_04785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRD69_04790	COG1575	Belongs to the MenA family. Type 1 subfamily
HRD69_04795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HRD69_04800	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HRD69_04805	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRD69_04810	COG1609	Transcriptional regulator
HRD69_04815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRD69_04820	COG0254	rRNA binding
HRD69_04825	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HRD69_04830	COG0626	cystathionine gamma-synthase activity
HRD69_04835	COG0527	aspartate kinase activity
HRD69_04835	COG0460	homoserine dehydrogenase
HRD69_04850	COG3152	Membrane
HRD69_04865	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HRD69_04875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRD69_04880	COG3678	ATP-independent chaperone mediated protein folding
HRD69_04885	COG0745	RESPONSE REGULATOR receiver
HRD69_04890	COG2205	protein histidine kinase activity
HRD69_04895	COG2169	Transcriptional regulator
HRD69_04895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRD69_04900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HRD69_04905	COG1045	serine acetyltransferase
HRD69_04910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRD69_04915	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HRD69_04920	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRD69_04925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRD69_04930	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HRD69_04935	COG4942	peptidase
HRD69_04940	COG2861	carbohydrate metabolic process
HRD69_04950	COG0156	8-amino-7-oxononanoate synthase activity
HRD69_04955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD69_04960	COG0859	PFAM glycosyl transferase family 9
HRD69_04965	COG0859	PFAM glycosyl transferase family 9
HRD69_04970	COG1519	Transferase
HRD69_04990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRD69_04995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRD69_05005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HRD69_05010	COG0756	dUTP diphosphatase activity
HRD69_05015	COG1309	transcriptional regulator
HRD69_05025	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD69_05030	COG2200	EAL domain
HRD69_05030	COG2199	diguanylate cyclase activity
HRD69_05035	COG4608	Belongs to the ABC transporter superfamily
HRD69_05040	COG0444	Belongs to the ABC transporter superfamily
HRD69_05045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD69_05050	COG0601	transmembrane transport
HRD69_05055	COG0747	negative chemotaxis
HRD69_05065	COG2831	hemolysin activation secretion protein
HRD69_05075	COG2271	Major facilitator Superfamily
HRD69_05080	COG3851	Histidine kinase
HRD69_05085	COG2197	response regulator
HRD69_05090	COG2194	sulfuric ester hydrolase activity
HRD69_05095	COG1764	response to oxidative stress
HRD69_05110	COG2986	histidine ammonia-lyase
HRD69_05115	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HRD69_05120	COG5001	Diguanylate cyclase
HRD69_05125	COG1024	Enoyl-CoA hydratase
HRD69_05130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD69_05140	COG2860	membrane
HRD69_05145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRD69_05160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD69_05165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD69_05170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRD69_05175	COG0786	glutamate:sodium symporter activity
HRD69_05180	COG2233	PERMEase
HRD69_05185	COG2982	Protein involved in outer membrane biogenesis
HRD69_05210	COG3423	Transcriptional regulator
HRD69_05225	COG2204	response regulator
HRD69_05230	COG0456	acetyltransferase
HRD69_05235	COG1490	D-aminoacyl-tRNA deacylase activity
HRD69_05240	COG1295	ribonuclease BN
HRD69_05245	COG1011	Hydrolase
HRD69_05260	COG3852	Histidine kinase
HRD69_05270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRD69_05275	COG3078	GTPase activator activity
HRD69_05285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD69_05285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRD69_05290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRD69_05295	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HRD69_05300	COG3084	Protein conserved in bacteria
HRD69_05310	COG1763	Mo-molybdopterin cofactor biosynthetic process
HRD69_05335	COG2186	Transcriptional regulator
HRD69_05340	COG0477	Major facilitator Superfamily
HRD69_05345	COG1609	Transcriptional regulator
HRD69_05350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD69_05355	COG1879	ABC-type sugar transport system periplasmic component
HRD69_05360	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD69_05365	COG1129	ABC transporter
HRD69_05370	COG1869	D-ribose catabolic process
HRD69_05375	COG3158	transport of potassium into the cell
HRD69_05380	COG0714	Associated with various cellular activities
HRD69_05385	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HRD69_05395	COG2502	aspartate--ammonia ligase
HRD69_05400	COG1522	sequence-specific DNA binding
HRD69_05405	COG0716	FMN binding
HRD69_05410	COG0445	tRNA wobble uridine modification
HRD69_05415	COG0357	Ribosomal RNA small subunit methyltransferase G
HRD69_05420	COG3312	ion transport
HRD69_05425	COG0356	it plays a direct role in the translocation of protons across the membrane
HRD69_05435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRD69_05440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRD69_05445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRD69_05455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRD69_05460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRD69_05465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRD69_05485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRD69_05490	COG0573	inorganic phosphate transmembrane transporter activity
HRD69_05495	COG0581	inorganic phosphate transmembrane transporter activity
HRD69_05505	COG0704	Plays a role in the regulation of phosphate uptake
HRD69_05510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD69_05515	COG0765	amino acid transport
HRD69_05520	COG0765	amino acid transport
HRD69_05525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD69_05530	COG2252	PERMEase
HRD69_05545	COG4191	Histidine kinase
HRD69_05550	COG0431	NADPH-dependent FMN reductase
HRD69_05555	COG0840	transmembrane signaling receptor activity
HRD69_05560	COG2011	ABC-type metal ion transport system permease component
HRD69_05565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRD69_05575	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRD69_05580	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRD69_05585	COG0706	membrane insertase activity
HRD69_05595	COG0594	ribonuclease P activity
HRD69_05600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRD69_05605	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRD69_05610	COG0592	DNA-directed DNA polymerase activity
HRD69_05620	COG0187	DNA topoisomerase II activity
HRD69_05625	COG0561	phosphatase activity
HRD69_05630	COG2423	ornithine cyclodeaminase activity
HRD69_05635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRD69_05645	COG0823	Involved in the tonB-independent uptake of proteins
HRD69_05650	COG5645	(Lipo)protein
HRD69_05665	COG0569	domain protein
HRD69_05665	COG2985	domain, Protein
HRD69_05675	COG4221	oxidoreductase activity
HRD69_05680	COG2814	Major facilitator Superfamily
HRD69_05685	COG1408	metallophosphoesterase
HRD69_05690	COG0583	DNA-binding transcription factor activity
HRD69_05705	COG0667	Aldo Keto reductase
HRD69_05710	COG2814	Major facilitator Superfamily
HRD69_05715	COG3977	Valine--pyruvate aminotransferase
HRD69_05720	COG0366	Alpha amylase catalytic
HRD69_05740	COG2885	chlorophyll binding
HRD69_05755	COG2818	Glycosylase
HRD69_05765	COG0752	glycyl-tRNA synthetase alpha subunit
HRD69_05770	COG0751	glycine-tRNA ligase activity
HRD69_05785	COG2213	PTS system mannitol-specific
HRD69_05785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD69_05790	COG0246	Mannitol dehydrogenase
HRD69_05795	COG3722	fumarate hydratase activity
HRD69_05805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD69_05825	COG2258	MOSC domain
HRD69_05830	COG0840	transmembrane signaling receptor activity
HRD69_05835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRD69_05840	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HRD69_05850	COG0437	4 iron, 4 sulfur cluster binding
HRD69_05855	COG2864	formate dehydrogenase
HRD69_05860	COG3058	Necessary for formate dehydrogenase activity
HRD69_05865	COG1921	L-seryl-tRNASec selenium transferase activity
HRD69_05870	COG3276	selenocysteine insertion sequence binding
HRD69_05875	COG3622	Belongs to the hyi family
HRD69_05880	COG0235	Class ii aldolase
HRD69_05885	COG3395	kinase activity
HRD69_05890	COG1349	DNA-binding transcription factor activity
HRD69_05895	COG2271	Major facilitator Superfamily
HRD69_05900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD69_05915	COG3274	enterobacterial common antigen metabolic process
HRD69_05925	COG1335	isochorismatase
HRD69_05930	COG1070	Carbohydrate kinase
HRD69_05935	COG2115	Belongs to the xylose isomerase family
HRD69_05940	COG4213	ABC transporter substrate-binding protein
HRD69_05950	COG4214	carbohydrate transport
HRD69_05955	COG2207	Transcriptional regulator
HRD69_05955	COG1609	Transcriptional regulator
HRD69_05965	COG0582	viral genome integration into host DNA
HRD69_06025	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRD69_06035	COG1396	sequence-specific DNA binding
HRD69_06040	COG3423	Transcriptional regulator
HRD69_06050	COG3645	SOS response
HRD69_06130	COG1561	YicC-like family, N-terminal region
HRD69_06135	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HRD69_06145	COG1301	dicarboxylic acid transport
HRD69_06150	COG0612	Peptidase, M16
HRD69_06155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD69_06160	COG1942	4-Oxalocrotonate Tautomerase
HRD69_06165	COG2200	EAL domain
HRD69_06170	COG2982	Protein involved in outer membrane biogenesis
HRD69_06175	COG2134	cdp-diacylglycerol pyrophosphatase
HRD69_06180	COG1295	ribonuclease BN
HRD69_06190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD69_06195	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HRD69_06205	COG0742	ribosomal rna small subunit methyltransferase
HRD69_06220	COG0589	response to stress
HRD69_06230	COG0306	phosphate transporter
HRD69_06235	COG2081	HI0933 family
HRD69_06280	COG0583	DNA-binding transcription factor activity
HRD69_06285	COG2814	Major facilitator Superfamily
HRD69_06305	COG3718	enzyme involved in inositol metabolism
HRD69_06315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD69_06320	COG3962	Belongs to the TPP enzyme family
HRD69_06325	COG0673	inositol 2-dehydrogenase activity
HRD69_06330	COG1082	Xylose isomerase domain protein TIM barrel
HRD69_06335	COG1247	-acetyltransferase
HRD69_06340	COG1741	Belongs to the pirin family
HRD69_06345	COG1609	Transcriptional regulator
HRD69_06350	COG2610	gluconate transmembrane transporter activity
HRD69_06355	COG3265	gluconokinase activity
HRD69_06360	COG2095	MarC family integral membrane protein
HRD69_06365	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRD69_06380	COG0463	Glycosyl transferase, family 2
HRD69_06400	COG3275	phosphorelay sensor kinase activity
HRD69_06405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRD69_06410	COG1523	belongs to the glycosyl hydrolase 13 family
HRD69_06420	COG0297	glycogen (starch) synthase activity
HRD69_06425	COG0058	SHG alpha-glucan phosphorylase activity
HRD69_06430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRD69_06440	COG1349	DNA-binding transcription factor activity
HRD69_06445	COG0705	Rhomboid family
HRD69_06460	COG2909	trisaccharide binding
HRD69_06465	COG0058	SHG alpha-glucan phosphorylase activity
HRD69_06470	COG1640	4-alpha-glucanotransferase
HRD69_06475	COG0316	Belongs to the HesB IscA family
HRD69_06475	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HRD69_06485	COG0596	Alpha beta hydrolase
HRD69_06500	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HRD69_06505	COG1918	ferrous iron import across plasma membrane
HRD69_06510	COG2183	response to ionizing radiation
HRD69_06515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRD69_06520	COG0745	RESPONSE REGULATOR receiver
HRD69_06535	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HRD69_06545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HRD69_06550	COG1011	Hydrolase
HRD69_06560	COG0494	nUDIX hydrolase
HRD69_06565	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRD69_06590	COG4796	Type ii and iii secretion system protein
HRD69_06595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRD69_06615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRD69_06625	COG0180	Tryptophanyl-tRNA synthetase
HRD69_06630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRD69_06630	COG1648	precorrin-2 dehydrogenase activity
HRD69_06645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD69_06650	COG0402	S-adenosylhomocysteine deaminase activity
HRD69_06655	COG0738	Major facilitator superfamily
HRD69_06670	COG1609	Transcriptional regulator
HRD69_06675	COG1486	melibiose metabolic process
HRD69_06680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRD69_06685	COG0433	COG0433 Predicted ATPase
HRD69_06700	COG1289	transmembrane transporter activity
HRD69_06710	COG1765	OsmC-like protein
HRD69_06715	COG3954	Phosphoribulokinase
HRD69_06720	COG3089	Belongs to the UPF0270 family
HRD69_06725	COG0429	hydrolase of the alpha beta-hydrolase fold
HRD69_06740	COG4521	taurine ABC transporter
HRD69_06750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRD69_06755	COG2175	clavaminate synthase activity
HRD69_06765	COG0488	(ABC) transporter
HRD69_06770	COG2249	NAD(P)H dehydrogenase (quinone) activity
HRD69_06780	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HRD69_06785	COG1047	Peptidyl-prolyl cis-trans
HRD69_06795	COG0545	Peptidyl-prolyl cis-trans isomerase
HRD69_06800	COG2964	Protein conserved in bacteria
HRD69_06805	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HRD69_06810	COG2923	Belongs to the DsrF TusC family
HRD69_06815	COG2168	tRNA wobble position uridine thiolation
HRD69_06820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRD69_06825	COG0049	tRNA binding
HRD69_06835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRD69_06850	COG0051	transcription antitermination factor activity, RNA binding
HRD69_06855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRD69_06865	COG0089	rRNA binding
HRD69_06870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRD69_06875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRD69_06880	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRD69_06885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRD69_06890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRD69_06895	COG0255	Belongs to the universal ribosomal protein uL29 family
HRD69_06900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRD69_06905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRD69_06920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRD69_06930	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRD69_06935	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRD69_06940	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRD69_06945	COG1841	ribosomal large subunit assembly
HRD69_06950	COG0200	Binds to the 23S rRNA
HRD69_06955	COG0201	protein transport
HRD69_06960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRD69_06965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRD69_06970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRD69_06975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRD69_06985	COG0203	ribosomal protein L17
HRD69_06990	COG0789	Transcriptional regulator
HRD69_06995	COG3036	rescue of stalled ribosome
HRD69_07000	COG1970	mechanosensitive ion channel activity
HRD69_07010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRD69_07010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRD69_07015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRD69_07020	COG0242	peptide deformylase activity
HRD69_07025	COG0758	DNA mediated transformation
HRD69_07035	COG0551	DNA topoisomerase type I activity
HRD69_07040	COG0009	L-threonylcarbamoyladenylate synthase
HRD69_07045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRD69_07050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HRD69_07080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRD69_07085	COG3162	membrane
HRD69_07090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRD69_07095	COG1301	dicarboxylic acid transport
HRD69_07115	COG2391	methyltransferase activity
HRD69_07120	COG0425	Belongs to the sulfur carrier protein TusA family
HRD69_07140	COG1191	sigma factor activity
HRD69_07145	COG3712	iron ion homeostasis
HRD69_07150	COG4771	TonB-dependent receptor
HRD69_07155	COG4178	(ABC) transporter
HRD69_07160	COG0612	Peptidase, M16
HRD69_07165	COG3397	chitin binding
HRD69_07175	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HRD69_07220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRD69_07230	COG3031	protein transport across the cell outer membrane
HRD69_07265	COG2205	protein histidine kinase activity
HRD69_07385	COG3264	Mechanosensitive ion channel
HRD69_07385	COG1196	nuclear chromosome segregation
HRD69_07400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD69_07405	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HRD69_07410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD69_07415	COG4558	Periplasmic binding protein
HRD69_07420	COG3720	iron ion transport
HRD69_07435	COG3721	Heme iron utilization protein
HRD69_07450	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HRD69_07460	COG0457	Tetratricopeptide repeat
HRD69_07465	COG1215	transferase activity, transferring glycosyl groups
HRD69_07475	COG0489	protein tyrosine kinase activity
HRD69_07485	COG3423	Transcriptional regulator
HRD69_07495	COG3916	Acyl-homoserine-lactone synthase
HRD69_07500	COG3391	amine dehydrogenase activity
HRD69_07510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRD69_07550	COG1309	transcriptional regulator
HRD69_07560	COG2084	Dehydrogenase
HRD69_07565	COG1929	Belongs to the glycerate kinase type-1 family
HRD69_07570	COG3835	regulator
HRD69_07575	COG2721	sulfolactate sulfo-lyase activity
HRD69_07580	COG2271	Major facilitator Superfamily
HRD69_07585	COG0493	'glutamate synthase
HRD69_07585	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD69_07590	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD69_07595	COG3383	formate dehydrogenase (NAD+) activity
HRD69_07600	COG4232	protein-disulfide reductase activity
HRD69_07610	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HRD69_07625	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRD69_07630	COG0459	protein refolding
HRD69_07655	COG3397	chitin binding
HRD69_07665	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HRD69_07670	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HRD69_07675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRD69_07680	COG1053	succinate dehydrogenase
HRD69_07690	COG3264	Mechanosensitive ion channel
HRD69_07690	COG1511	domain protein
HRD69_07695	COG0688	phosphatidylethanolamine metabolic process
HRD69_07700	COG1162	GTPase activity
HRD69_07705	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HRD69_07725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRD69_07730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRD69_07730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRD69_07735	COG0802	atpase or kinase
HRD69_07740	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRD69_07745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HRD69_07755	COG1923	regulation of RNA biosynthetic process
HRD69_07760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRD69_07765	COG0330	HflC and HflK could
HRD69_07770	COG0330	HflC and HflK could
HRD69_07775	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HRD69_07785	COG1959	2 iron, 2 sulfur cluster binding
HRD69_07790	COG0557	exoribonuclease II activity
HRD69_07795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD69_07800	COG1960	acyl-CoA dehydrogenase activity
HRD69_07805	COG3650	response to hydrogen peroxide
HRD69_07810	COG1073	alpha beta
HRD69_07820	COG0360	Binds together with S18 to 16S ribosomal RNA
HRD69_07830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRD69_07845	COG3061	Opacity-associated protein A
HRD69_07850	COG0545	Peptidyl-prolyl cis-trans isomerase
HRD69_07860	COG0737	Belongs to the 5'-nucleotidase family
HRD69_07865	COG1218	3'(2'),5'-bisphosphate nucleotidase
HRD69_07870	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HRD69_07880	COG1253	flavin adenine dinucleotide binding
HRD69_07885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRD69_07890	COG0729	surface antigen
HRD69_07900	COG2105	PFAM AIG2 family protein
HRD69_07905	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRD69_07915	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HRD69_07920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRD69_07940	COG3423	Transcriptional regulator
HRD69_07950	COG0142	geranyltranstransferase activity
HRD69_07965	COG0697	spore germination
HRD69_07970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRD69_07975	COG0642	Histidine kinase
HRD69_07980	COG0745	RESPONSE REGULATOR receiver
HRD69_07985	COG2027	D-alanyl-D-alanine carboxypeptidase
HRD69_07995	COG1534	Rna-binding protein
HRD69_08000	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HRD69_08010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRD69_08020	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRD69_08040	COG0195	Participates in both transcription termination and antitermination
HRD69_08050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRD69_08055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRD69_08065	COG1185	polyribonucleotide nucleotidyltransferase activity
HRD69_08080	COG0513	Belongs to the DEAD box helicase family
HRD69_08085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRD69_08105	COG0826	peptidase U32
HRD69_08110	COG0826	peptidase U32
HRD69_08115	COG3154	lipid carrier protein
HRD69_08120	COG3153	acetyltransferase
HRD69_08125	COG2827	Endonuclease containing a URI domain
HRD69_08130	COG0531	amino acid
HRD69_08135	COG1982	Orn Lys Arg decarboxylase major
HRD69_08145	COG3787	Belongs to the UPF0306 family
HRD69_08150	COG0702	epimerase
HRD69_08155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HRD69_08160	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HRD69_08165	COG3454	Phosphonate metabolism
HRD69_08170	COG4778	phosphonate C-P lyase system protein PhnL
HRD69_08175	COG4107	phosphonate C-P lyase system protein PhnK
HRD69_08180	COG3627	carbon phosphorus lyase activity
HRD69_08185	COG3626	phosphonate metabolism
HRD69_08190	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HRD69_08195	COG3624	Phosphonate C-P lyase system protein PhnG
HRD69_08200	COG2188	Transcriptional regulator
HRD69_08215	COG0602	queuosine metabolic process
HRD69_08225	COG4608	Belongs to the ABC transporter superfamily
HRD69_08230	COG0444	Belongs to the ABC transporter superfamily
HRD69_08235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD69_08240	COG0601	transmembrane transport
HRD69_08250	COG2731	YhcH YjgK YiaL family protein
HRD69_08260	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HRD69_08275	COG2927	DNA polymerase III (CHI subunit)
HRD69_08280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRD69_08285	COG0795	lipopolysaccharide-transporting ATPase activity
HRD69_08290	COG0795	lipopolysaccharide-transporting ATPase activity
HRD69_08300	COG0582	viral genome integration into host DNA
HRD69_08325	COG3338	carbonate dehydratase activity
HRD69_08330	COG3423	Transcriptional regulator
HRD69_08370	COG1830	Aldolase
HRD69_08375	COG1879	ABC-type sugar transport system periplasmic component
HRD69_08380	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD69_08385	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD69_08390	COG1129	ABC transporter
HRD69_08395	COG2390	Transcriptional regulator
HRD69_08400	COG1070	Carbohydrate kinase
HRD69_08405	COG0859	PFAM glycosyl transferase family 9
HRD69_08420	COG2235	arginine
HRD69_08435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD69_08440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD69_08460	COG2376	Dihydroxyacetone kinase
HRD69_08465	COG1461	Dihydroxyacetone kinase
HRD69_08470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD69_08470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD69_08470	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HRD69_08480	COG2192	nodulation
HRD69_08505	COG3284	Transcriptional regulator
HRD69_08535	COG3706	GGDEF domain
HRD69_08565	COG0667	Aldo Keto reductase
HRD69_08590	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HRD69_08595	COG2823	Periplasmic or secreted lipoprotein
HRD69_08605	COG4667	esterase of the alpha-beta hydrolase superfamily
HRD69_08610	COG0084	hydrolase, TatD family'
HRD69_08615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD69_08630	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HRD69_08640	COG3550	peptidyl-serine autophosphorylation
HRD69_08645	COG3726	membrane protein affecting hemolysin expression
HRD69_08650	COG0560	Phosphoserine phosphatase
HRD69_08665	COG0604	alcohol dehydrogenase
HRD69_08670	COG0583	DNA-binding transcription factor activity
HRD69_08680	COG0488	(ABC) transporter
HRD69_08685	COG2885	chlorophyll binding
HRD69_08690	COG2199	diguanylate cyclase activity
HRD69_08700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HRD69_08705	COG0741	lytic transglycosylase activity
HRD69_08710	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HRD69_08715	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HRD69_08725	COG2207	Transcriptional regulator
HRD69_08725	COG3708	Transcriptional regulator
HRD69_08730	COG3045	CreA protein
HRD69_08735	COG0745	RESPONSE REGULATOR receiver
HRD69_08750	COG0083	homoserine kinase activity
HRD69_08760	COG3022	response to hydroperoxide
HRD69_08765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRD69_08770	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRD69_08775	COG0477	Major facilitator Superfamily
HRD69_08785	COG1584	GPR1 FUN34 yaaH family protein
HRD69_08795	COG0484	heat shock protein binding
HRD69_08805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRD69_08810	COG0583	DNA-binding transcription factor activity
HRD69_08830	COG0196	riboflavin kinase activity
HRD69_08835	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRD69_08840	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRD69_08845	COG1047	Peptidyl-prolyl cis-trans
HRD69_08850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRD69_08855	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRD69_08865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRD69_08875	COG2966	Psort location CytoplasmicMembrane, score
HRD69_08885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HRD69_08890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRD69_08895	COG2967	ApaG domain
HRD69_08900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRD69_08915	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD69_08920	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HRD69_08930	COG0564	pseudouridine synthase activity
HRD69_08940	COG0417	DNA replication proofreading
HRD69_08945	COG0586	Pfam SNARE associated Golgi protein
HRD69_08955	COG1178	ABC-type Fe3 transport system permease component
HRD69_08960	COG4143	(ABC) transporter
HRD69_08980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRD69_08985	COG1882	Formate acetyltransferase
HRD69_08990	COG2814	Major facilitator Superfamily
HRD69_09000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRD69_09005	COG0473	3-isopropylmalate dehydrogenase activity
HRD69_09025	COG1022	Amp-dependent synthetase and ligase
HRD69_09030	COG0028	Belongs to the TPP enzyme family
HRD69_09055	COG0275	rRNA processing
HRD69_09060	COG3116	cell division
HRD69_09065	COG0768	penicillin binding
HRD69_09070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRD69_09075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRD69_09080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRD69_09090	COG0772	Belongs to the SEDS family
HRD69_09095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRD69_09100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRD69_09110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HRD69_09115	COG0849	cell division
HRD69_09120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HRD69_09140	COG0653	protein targeting
HRD69_09145	COG0494	nUDIX hydrolase
HRD69_09150	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HRD69_09165	COG0516	GMP reductase activity
HRD69_09170	COG1459	type II secretion system
HRD69_09175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRD69_09180	COG4969	Belongs to the N-Me-Phe pilin family
HRD69_09190	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRD69_09195	COG3725	Membrane protein required for beta-lactamase induction
HRD69_09205	COG1113	amino acid transport
HRD69_09210	COG2186	Transcriptional regulator
HRD69_09215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HRD69_09220	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD69_09225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRD69_09230	COG2207	Transcriptional regulator
HRD69_09245	COG3112	Uncharacterised protein family (UPF0231)
HRD69_09300	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HRD69_09310	COG2132	Multicopper oxidase
HRD69_09320	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HRD69_09325	COG0288	reversible hydration of carbon dioxide
HRD69_09330	COG1131	(ABC) transporter
HRD69_09335	COG0842	Transport permease protein
HRD69_09340	COG0726	polysaccharide deacetylase
HRD69_09345	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HRD69_09360	COG1289	transmembrane transporter activity
HRD69_09365	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRD69_09370	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRD69_09375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRD69_09385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRD69_09395	COG1489	DNA binding
HRD69_09400	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HRD69_09405	COG1643	Atp-dependent helicase
HRD69_09410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRD69_09415	COG1120	ATPase activity
HRD69_09420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRD69_09425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRD69_09435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRD69_09445	COG0316	Belongs to the HesB IscA family
HRD69_09455	COG2860	membrane
HRD69_09465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRD69_09470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRD69_09475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRD69_09485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRD69_09490	COG3956	TIGRFAM MazG family protein
HRD69_09495	COG0504	CTP synthase activity
HRD69_09500	COG0148	phosphopyruvate hydratase activity
HRD69_09515	COG0602	queuosine metabolic process
HRD69_09520	COG0720	synthase
HRD69_09525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HRD69_09530	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRD69_09535	COG0175	sulfate reduction
HRD69_09550	COG2234	aminopeptidase activity
HRD69_09555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRD69_09555	COG1648	precorrin-2 dehydrogenase activity
HRD69_09560	COG0175	sulfate reduction
HRD69_09565	COG2895	sulfate adenylyltransferase (ATP) activity
HRD69_09570	COG0529	Catalyzes the synthesis of activated sulfate
HRD69_09580	COG0698	ribose 5-phosphate isomerase
HRD69_09585	COG1063	alcohol dehydrogenase
HRD69_09590	COG2814	Major facilitator Superfamily
HRD69_09595	COG1028	Short-chain dehydrogenase reductase Sdr
HRD69_09600	COG2376	Dihydroxyacetone kinase
HRD69_09605	COG1461	Dihydroxyacetone kinase
HRD69_09610	COG2390	Transcriptional regulator
HRD69_09615	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HRD69_09625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRD69_09630	COG0585	pseudouridine synthase activity
HRD69_09635	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRD69_09640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRD69_09645	COG1388	LysM domain
HRD69_09645	COG4942	peptidase
HRD69_09650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRD69_09655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HRD69_09680	COG3188	usher protein
HRD69_09685	COG3121	Chaperone
HRD69_09695	COG3539	Fimbrial protein
HRD69_09700	COG3539	Fimbrial protein
HRD69_09730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD69_09740	COG1538	Outer membrane efflux protein
HRD69_09760	COG1028	Short-chain dehydrogenase reductase Sdr
HRD69_09790	COG4948	Mandelate Racemase Muconate Lactonizing
HRD69_09795	COG0747	negative chemotaxis
HRD69_09800	COG0601	transmembrane transport
HRD69_09810	COG0444	Belongs to the ABC transporter superfamily
HRD69_09815	COG4608	Belongs to the ABC transporter superfamily
HRD69_09820	COG2214	Heat shock protein DnaJ domain protein
HRD69_09825	COG0443	Heat shock 70 kDa protein
HRD69_09835	COG0765	amino acid transport
HRD69_09840	COG0765	amino acid transport
HRD69_09845	COG1126	abc transporter atp-binding protein
HRD69_09850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD69_09865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRD69_09870	COG0640	Transcriptional regulator
HRD69_09905	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD69_09905	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HRD69_09920	COG1129	ABC transporter
HRD69_09925	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD69_09930	COG3959	Transketolase, thiamine diphosphate binding domain
HRD69_09935	COG3958	Transketolase
HRD69_09940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRD69_09965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRD69_09970	COG2137	regulation of response to DNA damage stimulus
HRD69_09975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRD69_09980	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HRD69_10005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD69_10010	COG1238	metal cluster binding
HRD69_10015	COG2918	glutathione biosynthetic process
HRD69_10020	COG1854	S-ribosylhomocysteine lyase activity
HRD69_10025	COG4536	flavin adenine dinucleotide binding
HRD69_10030	COG4137	Cytochrome C assembly protein
HRD69_10035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HRD69_10045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRD69_10055	COG0335	large ribosomal subunit rRNA binding
HRD69_10060	COG3137	Salt-induced outer membrane protein
HRD69_10065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HRD69_10070	COG3279	Response regulator of the LytR AlgR family
HRD69_10075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRD69_10080	COG0287	Prephenate dehydrogenase
HRD69_10080	COG1605	Chorismate mutase
HRD69_10085	COG1605	Chorismate mutase
HRD69_10085	COG0077	Prephenate dehydratase
HRD69_10090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRD69_10095	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD69_10100	COG0564	pseudouridine synthase activity
HRD69_10110	COG0542	response to heat
HRD69_10155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRD69_10160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD69_10160	COG0045	succinate-CoA ligase (ADP-forming) activity
HRD69_10160	COG1042	CoA-binding domain protein
HRD69_10170	COG3118	belongs to the thioredoxin family
HRD69_10175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRD69_10180	COG2814	Major facilitator Superfamily
HRD69_10185	COG1566	PFAM secretion protein HlyD family protein
HRD69_10190	COG1846	Transcriptional regulator
HRD69_10200	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HRD69_10215	COG0436	Aminotransferase
HRD69_10220	COG0235	Class ii aldolase
HRD69_10230	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HRD69_10240	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HRD69_10255	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
HRD69_10260	COG1960	acyl-CoA dehydrogenase activity
HRD69_10270	COG0121	glutamine amidotransferase
HRD69_10275	COG3034	peptidoglycan biosynthetic process
HRD69_10280	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD69_10285	COG1805	sodium ion transport
HRD69_10290	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD69_10295	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD69_10300	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HRD69_10305	COG2871	sodium ion transport
HRD69_10310	COG1477	protein flavinylation
HRD69_10315	COG2991	Protein conserved in bacteria
HRD69_10325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRD69_10330	COG2195	Cleaves the N-terminal amino acid of tripeptides
HRD69_10355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRD69_10365	COG3459	Glycosyltransferase 36 associated
HRD69_10390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRD69_10395	COG3123	guanosine phosphorylase activity
HRD69_10400	COG2974	May be involved in recombination
HRD69_10405	COG1940	carbohydrate kinase activity
HRD69_10410	COG0419	ATPase involved in DNA repair
HRD69_10415	COG0420	3'-5' exonuclease activity
HRD69_10420	COG0745	RESPONSE REGULATOR receiver
HRD69_10425	COG5002	protein histidine kinase activity
HRD69_10445	COG0366	Alpha amylase catalytic
HRD69_10465	COG0450	alkyl hydroperoxide reductase
HRD69_10470	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HRD69_10475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HRD69_10485	COG0343	queuine tRNA-ribosyltransferase activity
HRD69_10490	COG1862	Preprotein translocase
HRD69_10495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRD69_10500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRD69_10505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRD69_10510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRD69_10510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRD69_10515	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HRD69_10525	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HRD69_10530	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HRD69_10535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRD69_10540	COG0142	geranyltranstransferase activity
HRD69_10550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRD69_10550	COG0301	tRNA thio-modification
HRD69_10555	COG0693	protein deglycase activity
HRD69_10560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HRD69_10565	COG1666	GTP binding
HRD69_10570	COG2814	Major facilitator Superfamily
HRD69_10575	COG0109	protoheme IX farnesyltransferase activity
HRD69_10580	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HRD69_10585	COG1845	cytochrome c oxidase, subunit III
HRD69_10590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRD69_10595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HRD69_10605	COG2223	nitrite transmembrane transporter activity
HRD69_10610	COG3056	Lipoprotein
HRD69_10615	COG0271	Belongs to the BolA IbaG family
HRD69_10620	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRD69_10625	COG0740	serine-type endopeptidase activity
HRD69_10630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRD69_10635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRD69_10640	COG0776	regulation of translation
HRD69_10645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRD69_10650	COG1555	photosystem II stabilization
HRD69_10655	COG0824	Thioesterase
HRD69_10660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRD69_10665	COG4533	DNA binding
HRD69_10670	COG0561	phosphatase activity
HRD69_10680	COG1522	sequence-specific DNA binding
HRD69_10685	COG1132	(ABC) transporter
HRD69_10690	COG1132	(ABC) transporter
HRD69_10695	COG0347	Belongs to the P(II) protein family
HRD69_10700	COG0004	ammonium transporteR
HRD69_10705	COG1946	Acyl-CoA thioesterase
HRD69_10710	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HRD69_10715	COG3695	enzyme binding
HRD69_10740	COG1121	(ABC) transporter
HRD69_10745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD69_10750	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRD69_10755	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRD69_10760	COG0254	rRNA binding
HRD69_10765	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HRD69_10770	COG3457	Alanine racemase
HRD69_10775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD69_10780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD69_10785	COG1309	transcriptional regulator
HRD69_10790	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HRD69_10795	COG3264	Mechanosensitive ion channel
HRD69_10795	COG1196	nuclear chromosome segregation
HRD69_10810	COG2832	Protein of unknown function (DUF454)
HRD69_10815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRD69_10820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRD69_10830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRD69_10835	COG0326	Molecular chaperone. Has ATPase activity
HRD69_10840	COG0563	adenylate kinase activity
HRD69_10845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRD69_10850	COG0543	2 iron, 2 sulfur cluster binding
HRD69_10850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD69_10855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRD69_10870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD69_10875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD69_10910	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HRD69_10915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD69_10930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRD69_10935	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HRD69_10940	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HRD69_10955	COG1215	transferase activity, transferring glycosyl groups
HRD69_10965	COG0463	Glycosyl transferase, family 2
HRD69_10970	COG2226	methyltransferase
HRD69_10980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD69_10985	COG0300	oxidoreductase activity
HRD69_10990	COG0673	inositol 2-dehydrogenase activity
HRD69_11010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HRD69_11015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRD69_11030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRD69_11035	COG4651	solute:proton antiporter activity
HRD69_11035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRD69_11040	COG2223	nitrite transmembrane transporter activity
HRD69_11045	COG0737	Belongs to the 5'-nucleotidase family
HRD69_11055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRD69_11060	COG3735	TraB family
HRD69_11065	COG2217	Heavy metal translocating P-type atpase
HRD69_11070	COG0789	Transcriptional regulator
HRD69_11075	COG1585	Membrane protein implicated in regulation of membrane protease activity
HRD69_11080	COG0330	HflC and HflK could
HRD69_11085	COG3118	belongs to the thioredoxin family
HRD69_11090	COG0300	oxidoreductase activity
HRD69_11095	COG2755	lipolytic protein G-D-S-L family
HRD69_11100	COG4181	ATPase activity
HRD69_11105	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HRD69_11110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HRD69_11115	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRD69_11120	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRD69_11125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRD69_11130	COG0215	cysteine-tRNA ligase activity
HRD69_11135	COG2501	S4 domain
HRD69_11140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRD69_11150	COG0582	viral genome integration into host DNA
HRD69_11195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRD69_11205	COG2197	response regulator
HRD69_11210	COG1278	Cold shock
HRD69_11225	COG3706	GGDEF domain
HRD69_11230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRD69_11235	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRD69_11240	COG0321	lipoyl(octanoyl) transferase activity
HRD69_11245	COG2921	Belongs to the UPF0250 family
HRD69_11250	COG1686	Belongs to the peptidase S11 family
HRD69_11255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRD69_11260	COG0772	Belongs to the SEDS family
HRD69_11265	COG0768	penicillin binding
HRD69_11275	COG0799	negative regulation of ribosome biogenesis
HRD69_11280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRD69_11285	COG1466	dna polymerase III delta subunit
HRD69_11290	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HRD69_11295	COG0495	leucyl-tRNA aminoacylation
HRD69_11300	COG2888	peptidyl-tyrosine sulfation
HRD69_11305	COG1126	abc transporter atp-binding protein
HRD69_11310	COG0765	amino acid transport
HRD69_11315	COG0765	amino acid transport
HRD69_11330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRD69_11335	COG4535	Mg2 and Co2 transporter CorC
HRD69_11340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRD69_11345	COG1702	phosphate starvation-inducible protein PhoH
HRD69_11350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRD69_11355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRD69_11390	COG0367	asparagine synthase
HRD69_11395	COG0647	UMP catabolic process
HRD69_11400	COG1846	Transcriptional regulator
HRD69_11400	COG1940	carbohydrate kinase activity
HRD69_11405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRD69_11415	COG1263	PTS System
HRD69_11415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD69_11415	COG2190	(PTS) system
HRD69_11420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRD69_11435	COG0735	belongs to the Fur family
HRD69_11445	COG0840	transmembrane signaling receptor activity
HRD69_11455	COG0596	Alpha beta hydrolase
HRD69_11460	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HRD69_11465	COG0033	Phosphoglucomutase
HRD69_11480	COG0745	RESPONSE REGULATOR receiver
HRD69_11485	COG2205	protein histidine kinase activity
HRD69_11495	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HRD69_11500	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HRD69_11515	COG3272	Protein of unknown function (DUF1722)
HRD69_11525	COG5212	phosphodiesterase
HRD69_11530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRD69_11535	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HRD69_11540	COG1984	allophanate hydrolase subunit 2
HRD69_11545	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HRD69_11575	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HRD69_11580	COG1053	succinate dehydrogenase
HRD69_11585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRD69_11590	COG0567	Dehydrogenase, E1 component
HRD69_11595	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRD69_11605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HRD69_11610	COG0737	Belongs to the 5'-nucleotidase family
HRD69_11615	COG1271	oxidase subunit
HRD69_11620	COG1294	oxidase, subunit
HRD69_11625	COG4890	Cyd operon protein YbgT
HRD69_11630	COG3790	cyd operon protein YbgE
HRD69_11635	COG0824	Thioesterase
HRD69_11640	COG0811	peptide transport
HRD69_11645	COG0848	biopolymer transport protein
HRD69_11650	COG3064	Membrane
HRD69_11650	COG3064	Membrane
HRD69_11655	COG0823	Involved in the tonB-independent uptake of proteins
HRD69_11660	COG2885	chlorophyll binding
HRD69_11665	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HRD69_11705	COG1230	cation diffusion facilitator family transporter
HRD69_11710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRD69_11715	COG0588	phosphoglycerate mutase activity
HRD69_11725	COG2017	converts alpha-aldose to the beta-anomer
HRD69_11730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HRD69_11735	COG1085	galactose-1-phosphate uridylyltransferase
HRD69_11740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRD69_11750	COG1119	ATPase activity
HRD69_11755	COG3585	molybdate ion transport
HRD69_11755	COG2005	Transcriptional regulator
HRD69_11765	COG0725	ABC transporter, periplasmic molybdate-binding protein
HRD69_11770	COG4149	molybdate abc transporter
HRD69_11780	COG3037	sugar-specific permease SgaT UlaA
HRD69_11790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD69_11795	COG1609	Transcriptional regulator
HRD69_11800	COG0280	phosphate acetyltransferase
HRD69_11800	COG0857	belongs to the CobB CobQ family
HRD69_11810	COG3092	negative regulation of chromosome organization
HRD69_11815	COG3013	Belongs to the UPF0304 family
HRD69_11820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD69_11825	COG0471	metal ion transport
HRD69_11825	COG0490	domain, Protein
HRD69_11830	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HRD69_11835	COG0436	Aminotransferase
HRD69_11840	COG0583	DNA-binding transcription factor activity
HRD69_11845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD69_11850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD69_11855	COG0649	NAD binding
HRD69_11855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD69_11870	COG1034	ATP synthesis coupled electron transport
HRD69_11875	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRD69_11880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD69_11885	COG0839	Belongs to the complex I subunit 6 family
HRD69_11890	COG0713	ATP synthesis coupled electron transport
HRD69_11895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRD69_11900	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD69_11905	COG1007	ATP synthesis coupled electron transport
HRD69_11925	COG2731	YhcH YjgK YiaL family protein
HRD69_11930	COG3265	gluconokinase activity
HRD69_11935	COG1028	Short-chain dehydrogenase reductase Sdr
HRD69_11940	COG1609	Transcriptional regulator
HRD69_11945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRD69_11960	COG0129	dihydroxy-acid dehydratase activity
HRD69_11965	COG4575	ribosome binding
HRD69_11980	COG1169	isochorismate synthase
HRD69_11985	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HRD69_11995	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HRD69_12000	COG1441	menaquinone biosynthetic process
HRD69_12025	COG0814	amino acid
HRD69_12045	COG4574	serine-type endopeptidase inhibitor activity
HRD69_12050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD69_12060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRD69_12065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD69_12075	COG2205	protein histidine kinase activity
HRD69_12075	COG0784	Response regulator, receiver
HRD69_12085	COG2198	Histidine kinase
HRD69_12085	COG0642	Histidine kinase
HRD69_12090	COG2223	nitrite transmembrane transporter activity
HRD69_12105	COG1132	(ABC) transporter
HRD69_12120	COG2840	Smr protein MutS2
HRD69_12125	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD69_12130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRD69_12135	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HRD69_12140	COG0730	response to heat
HRD69_12145	COG3101	peptidyl-lysine hydroxylation
HRD69_12155	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HRD69_12155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRD69_12160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD69_12170	COG1794	racemase activity, acting on amino acids and derivatives
HRD69_12180	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HRD69_12195	COG4232	protein-disulfide reductase activity
HRD69_12205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD69_12220	COG0697	spore germination
HRD69_12235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRD69_12245	COG0586	Pfam SNARE associated Golgi protein
HRD69_12255	COG0285	dihydrofolate synthase activity
HRD69_12260	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HRD69_12265	COG1286	toxin biosynthetic process
HRD69_12270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HRD69_12280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD69_12285	COG4215	(ABC) transporter
HRD69_12290	COG4160	amino acid transport
HRD69_12300	COG1090	epimerase
HRD69_12310	COG0622	Phosphoesterase
HRD69_12315	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HRD69_12320	COG0561	phosphatase activity
HRD69_12325	COG2706	6-phosphogluconolactonase activity
HRD69_12335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRD69_12340	COG0156	8-amino-7-oxononanoate synthase activity
HRD69_12345	COG2226	methyltransferase
HRD69_12360	COG0556	nucleotide-excision repair
HRD69_12365	COG4628	conserved protein (DUF2132)
HRD69_12370	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HRD69_12375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRD69_12380	COG0315	cyclic pyranopterin monophosphate synthase activity
HRD69_12385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HRD69_12390	COG0314	molybdopterin synthase activity
HRD69_12395	COG0670	Belongs to the BI1 family
HRD69_12400	COG0842	Transport permease protein
HRD69_12405	COG0842	Transport permease protein
HRD69_12410	COG1131	(ABC) transporter
HRD69_12415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD69_12420	COG1309	transcriptional regulator
HRD69_12425	COG0513	Belongs to the DEAD box helicase family
HRD69_12430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRD69_12445	COG1686	Belongs to the peptidase S11 family
HRD69_12450	COG0277	FAD linked oxidase domain protein
HRD69_12470	COG2261	transglycosylase associated protein
HRD69_12480	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HRD69_12495	COG4807	Protein conserved in bacteria
HRD69_12525	COG2897	thiosulfate sulfurtransferase activity
HRD69_12540	COG1732	Glycine betaine
HRD69_12545	COG1174	glycine betaine transport
HRD69_12550	COG1125	glycine betaine transport
HRD69_12555	COG1174	glycine betaine transport
HRD69_12570	COG0697	spore germination
HRD69_12590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRD69_12595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRD69_12605	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HRD69_12615	COG1126	abc transporter atp-binding protein
HRD69_12620	COG0765	amino acid transport
HRD69_12625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD69_12630	COG0783	Belongs to the Dps family
HRD69_12635	COG4106	trans-aconitate 2-methyltransferase activity
HRD69_12650	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HRD69_12665	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HRD69_12685	COG0488	(ABC) transporter
HRD69_12690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRD69_12695	COG0303	'Molybdopterin
HRD69_12705	COG0477	Major facilitator Superfamily
HRD69_12710	COG0577	efflux transmembrane transporter activity
HRD69_12710	COG1136	(ABC) transporter
HRD69_12735	COG0583	DNA-binding transcription factor activity
HRD69_12740	COG0477	Major facilitator Superfamily
HRD69_12745	COG0302	gtp cyclohydrolase
HRD69_12750	COG2311	Membrane
HRD69_12775	COG3604	Transcriptional regulator
HRD69_12780	COG3383	formate dehydrogenase (NAD+) activity
HRD69_12785	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD69_12790	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HRD69_12800	COG3260	NADH ubiquinone oxidoreductase 20
HRD69_12805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD69_12810	COG3261	NADH dehydrogenase
HRD69_12810	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HRD69_12815	COG0651	ATP synthesis coupled electron transport
HRD69_12820	COG4237	Hydrogenase 4 membrane
HRD69_12825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRD69_12830	COG0650	Formate hydrogenlyase subunit 4
HRD69_12835	COG0651	ATP synthesis coupled electron transport
HRD69_12840	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD69_12845	COG0375	protein maturation
HRD69_12850	COG0298	carbon dioxide binding
HRD69_12855	COG2949	membrane
HRD69_12860	COG0281	malic enzyme
HRD69_12870	COG1346	cytolysis
HRD69_12875	COG1380	Effector of murein hydrolase LrgA
HRD69_12880	COG2814	Major facilitator Superfamily
HRD69_12895	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD69_12895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRD69_12900	COG0489	protein tyrosine kinase activity
HRD69_12905	COG0572	uridine kinase
HRD69_12915	COG2982	Protein involved in outer membrane biogenesis
HRD69_12920	COG3069	C4-dicarboxylate transmembrane transporter activity
HRD69_12925	COG1253	flavin adenine dinucleotide binding
HRD69_12930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRD69_12935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRD69_12940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRD69_12945	COG0140	phosphoribosyl-ATP diphosphatase activity
HRD69_12945	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRD69_12965	COG0131	Imidazoleglycerol-phosphate dehydratase
HRD69_12965	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HRD69_12970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD69_12975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRD69_12980	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRD69_12990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD69_12995	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD69_13000	COG1129	ABC transporter
HRD69_13005	COG0371	Dehydrogenase
HRD69_13010	COG0531	amino acid
HRD69_13015	COG2925	Exonuclease
HRD69_13025	COG1289	transmembrane transporter activity
HRD69_13030	COG2926	Belongs to the UPF0265 family
HRD69_13040	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD69_13045	COG1129	ABC transporter
HRD69_13060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRD69_13070	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HRD69_13090	COG4656	Part of a membrane complex involved in electron transport
HRD69_13100	COG1012	belongs to the aldehyde dehydrogenase family
HRD69_13185	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HRD69_13195	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HRD69_13260	COG1492	cobalamin metabolic process
HRD69_13280	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HRD69_13285	COG0583	DNA-binding transcription factor activity
HRD69_13295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HRD69_13300	COG2211	Major facilitator Superfamily
HRD69_13310	COG0534	Mate efflux family protein
HRD69_13315	COG0835	chemotaxis
HRD69_13315	COG0784	Response regulator, receiver
HRD69_13320	COG0488	(ABC) transporter
HRD69_13325	COG3122	Protein conserved in bacteria
HRD69_13340	COG1187	pseudouridine synthase activity
HRD69_13345	COG3121	Chaperone
HRD69_13360	COG3121	Chaperone
HRD69_13370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD69_13370	COG2205	protein histidine kinase activity
HRD69_13385	COG3842	ATPase activity
HRD69_13395	COG1840	ABC-type Fe3 transport system, periplasmic component
HRD69_13400	COG2271	Major facilitator Superfamily
HRD69_13415	COG4565	transcriptional regulatory protein
HRD69_13420	COG3290	protein histidine kinase activity
HRD69_13425	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HRD69_13430	COG3052	prosthetic group binding
HRD69_13435	COG2301	Belongs to the HpcH HpaI aldolase family
HRD69_13440	COG3051	citrate lyase alpha subunit
HRD69_13455	COG0471	metal ion transport
HRD69_13475	COG3228	Belongs to the MtfA family
HRD69_13510	COG0604	alcohol dehydrogenase
HRD69_13510	COG1028	Short-chain dehydrogenase reductase Sdr
HRD69_13510	COG3321	synthase
HRD69_13515	COG3250	beta-galactosidase activity
HRD69_13520	COG1609	Transcriptional regulator
HRD69_13535	COG0840	transmembrane signaling receptor activity
HRD69_13540	COG1285	pathogenesis
HRD69_13550	COG0589	response to stress
HRD69_13575	COG0643	Histidine kinase
HRD69_13575	COG2198	Histidine kinase
HRD69_13580	COG0835	chemotaxis
HRD69_13585	COG0840	transmembrane signaling receptor activity
HRD69_13590	COG0840	transmembrane signaling receptor activity
HRD69_13595	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HRD69_13605	COG0745	RESPONSE REGULATOR receiver
HRD69_13610	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HRD69_13615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD69_13620	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRD69_13635	COG3418	PFAM FlgN family protein
HRD69_13640	COG2747	anti-sigma28 factor FlgM
HRD69_13650	COG1815	bacterial-type flagellum-dependent cell motility
HRD69_13655	COG1558	bacterial-type flagellum-dependent cell motility
HRD69_13660	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HRD69_13700	COG1256	bacterial-type flagellum assembly
HRD69_13705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRD69_13760	COG1317	bacterial-type flagellum organization
HRD69_13775	COG1677	Flagellar hook-basal body complex protein FliE
HRD69_13785	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HRD69_13820	COG1191	sigma factor activity
HRD69_13830	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HRD69_13860	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRD69_13860	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HRD69_13860	COG0506	proline dehydrogenase activity
HRD69_13865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRD69_13870	COG0672	)-iron permease
HRD69_13875	COG2822	iron ion transport
HRD69_13890	COG0477	Major facilitator Superfamily
HRD69_13900	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HRD69_13905	COG1113	amino acid transport
HRD69_13915	COG2226	methyltransferase
HRD69_13935	COG0840	transmembrane signaling receptor activity
HRD69_13945	COG3136	membrane protein required for alginate biosynthesis
HRD69_13955	COG2197	response regulator
HRD69_13960	COG0322	excinuclease ABC activity
HRD69_13965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRD69_14025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HRD69_14165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRD69_14215	COG0840	transmembrane signaling receptor activity
HRD69_14220	COG2873	o-acetylhomoserine
HRD69_14225	COG0702	epimerase
HRD69_14230	COG1733	regulation of RNA biosynthetic process
HRD69_14240	COG3755	Protein conserved in bacteria
HRD69_14250	COG2203	Gaf domain
HRD69_14250	COG3706	GGDEF domain
HRD69_14250	COG4251	negative regulation of phosphorylation
HRD69_14250	COG5001	Diguanylate cyclase
HRD69_14260	COG1132	(ABC) transporter
HRD69_14275	COG2207	Transcriptional regulator
HRD69_14310	COG1113	amino acid transport
HRD69_14335	COG0768	penicillin binding
HRD69_14340	COG2226	methyltransferase
HRD69_14350	COG5001	Diguanylate cyclase
HRD69_14350	COG3447	MASE1 domain protein
HRD69_14350	COG5002	protein histidine kinase activity
HRD69_14360	COG1971	Probably functions as a manganese efflux pump
HRD69_14365	COG4811	Protein of unknown function (DUF986)
HRD69_14370	COG3716	PTS system mannose fructose sorbose family IID component
HRD69_14375	COG3715	PTS system
HRD69_14380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD69_14380	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD69_14385	COG1253	flavin adenine dinucleotide binding
HRD69_14390	COG1760	l-serine dehydratase
HRD69_14395	COG0494	nUDIX hydrolase
HRD69_14405	COG3140	Belongs to the UPF0181 family
HRD69_14410	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HRD69_14415	COG0513	Belongs to the DEAD box helicase family
HRD69_14425	COG1770	oligopeptidase
HRD69_14440	COG1528	Iron-storage protein
HRD69_14445	COG2372	response to copper ion
HRD69_14450	COG1276	copper resistance
HRD69_14530	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HRD69_14545	COG0625	glutathione transferase activity
HRD69_14565	COG2203	Gaf domain
HRD69_14565	COG3706	GGDEF domain
HRD69_14565	COG5001	Diguanylate cyclase
HRD69_14565	COG4251	negative regulation of phosphorylation
HRD69_14600	COG2814	Major facilitator Superfamily
HRD69_14610	COG3008	intermembrane lipid transfer
HRD69_14615	COG2995	paraquat-inducible protein a
HRD69_14620	COG1956	GAF domain-containing protein
HRD69_14630	COG0793	Belongs to the peptidase S41A family
HRD69_14635	COG0501	Belongs to the peptidase M48B family
HRD69_14640	COG2814	Major facilitator Superfamily
HRD69_14645	COG0823	Involved in the tonB-independent uptake of proteins
HRD69_14655	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRD69_14665	COG1988	membrane-bound metal-dependent
HRD69_14670	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRD69_14680	COG3842	ATPase activity
HRD69_14685	COG0395	ABC-type sugar transport system, permease component
HRD69_14690	COG1175	transmembrane transport
HRD69_14700	COG1028	Short-chain dehydrogenase reductase Sdr
HRD69_14705	COG1917	Cupin 2, conserved barrel domain protein
HRD69_14710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRD69_14720	COG0583	DNA-binding transcription factor activity
HRD69_14725	COG0427	acetyl-CoA hydrolase
HRD69_14730	COG1024	Enoyl-CoA hydratase
HRD69_14735	COG1703	isobutyryl-CoA mutase activity
HRD69_14740	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRD69_14740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRD69_14745	COG3001	Fructosamine kinase
HRD69_14750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD69_14755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD69_14760	COG1121	(ABC) transporter
HRD69_14765	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRD69_14795	COG1811	Na channel or pump
HRD69_14800	COG4249	Peptidase C14 caspase catalytic subunit p20
HRD69_14810	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRD69_14815	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRD69_14840	COG0776	regulation of translation
HRD69_14845	COG2719	SpoVR family
HRD69_14855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRD69_14860	COG0642	Histidine kinase
HRD69_14870	COG3111	PFAM Bacterial OB fold (BOF) protein
HRD69_14875	COG2814	Major facilitator Superfamily
HRD69_14880	COG2200	EAL domain
HRD69_14880	COG2202	Pas domain
HRD69_14880	COG2199	diguanylate cyclase activity
HRD69_14890	COG0583	DNA-binding transcription factor activity
HRD69_14900	COG2718	Belongs to the UPF0229 family
HRD69_14905	COG2766	serine protein kinase
HRD69_14910	COG3713	MltA-interacting MipA family protein
HRD69_14940	COG3139	Protein of unknown function (DUF1315)
HRD69_14945	COG1335	isochorismatase
HRD69_14950	COG0252	asparaginase activity
HRD69_14955	COG0616	signal peptide processing
HRD69_14960	COG0778	Nitroreductase
HRD69_14970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRD69_14980	COG0494	nUDIX hydrolase
HRD69_14985	COG0708	Exodeoxyribonuclease III
HRD69_14990	COG0583	DNA-binding transcription factor activity
HRD69_15015	COG0788	formyltetrahydrofolate deformylase activity
HRD69_15020	COG3012	SEC-C Motif Domain Protein
HRD69_15025	COG0745	RESPONSE REGULATOR receiver
HRD69_15035	COG2916	Histone family protein nucleoid-structuring protein H-NS
HRD69_15045	COG1012	belongs to the aldehyde dehydrogenase family
HRD69_15045	COG1454	alcohol dehydrogenase
HRD69_15050	COG2095	MarC family integral membrane protein
HRD69_15055	COG4166	transmembrane transport
HRD69_15070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRD69_15075	COG0444	Belongs to the ABC transporter superfamily
HRD69_15090	COG3099	Belongs to the UPF0263 family
HRD69_15095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRD69_15105	COG2200	EAL domain
HRD69_15120	COG2350	Protein conserved in bacteria
HRD69_15125	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HRD69_15135	COG2917	probably involved in intracellular septation
HRD69_15150	COG3047	cAMP biosynthetic process
HRD69_15160	COG0159	tryptophan synthase activity
HRD69_15165	COG0133	tryptophan synthase activity
HRD69_15170	COG0134	indole-3-glycerol-phosphate synthase activity
HRD69_15170	COG0135	phosphoribosylanthranilate isomerase activity
HRD69_15185	COG0613	PHP domain protein
HRD69_15190	COG0009	L-threonylcarbamoyladenylate synthase
HRD69_15245	COG1187	pseudouridine synthase activity
HRD69_15255	COG1028	Short-chain dehydrogenase reductase Sdr
HRD69_15260	COG0616	signal peptide processing
HRD69_15275	COG0583	DNA-binding transcription factor activity
HRD69_15285	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRD69_15295	COG0671	phosphoesterase, PA-phosphatase related
HRD69_15300	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HRD69_15305	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HRD69_15325	COG0023	Translation Initiation Factor
HRD69_15335	COG0235	Class ii aldolase
HRD69_15345	COG1349	DNA-binding transcription factor activity
HRD69_15350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRD69_15355	COG2879	small protein
HRD69_15360	COG1966	Carbon starvation protein
HRD69_15365	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HRD69_15370	COG0243	molybdopterin cofactor binding
HRD69_15375	COG0791	NLP P60 protein
HRD69_15385	COG3121	Chaperone
HRD69_15390	COG3188	usher protein
HRD69_15405	COG1733	regulation of RNA biosynthetic process
HRD69_15410	COG0604	alcohol dehydrogenase
HRD69_15445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HRD69_15455	COG4659	FMN binding
HRD69_15465	COG2207	Transcriptional regulator
HRD69_15465	COG3708	Transcriptional regulator
HRD69_15480	COG4657	Part of a membrane complex involved in electron transport
HRD69_15490	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HRD69_15495	COG2274	protein secretion by the type I secretion system
HRD69_15505	COG2274	protein secretion by the type I secretion system
HRD69_15520	COG1879	ABC-type sugar transport system periplasmic component
HRD69_15525	COG1129	ABC transporter
HRD69_15530	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRD69_15540	COG0673	inositol 2-dehydrogenase activity
HRD69_15545	COG0385	Bile acid
HRD69_15550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRD69_15560	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRD69_15565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD69_15565	COG1263	PTS System
HRD69_15570	COG1609	Transcriptional regulator
HRD69_15580	COG5339	Protein conserved in bacteria
HRD69_15585	COG1482	cell wall glycoprotein biosynthetic process
HRD69_15590	COG0114	fumarate hydratase activity
HRD69_15605	COG2814	Major facilitator Superfamily
HRD69_15610	COG0583	DNA-binding transcription factor activity
HRD69_15615	COG1940	carbohydrate kinase activity
HRD69_15620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HRD69_15640	COG1742	UPF0060 membrane protein
HRD69_15650	COG4221	oxidoreductase activity
HRD69_15675	COG0625	glutathione transferase activity
HRD69_15685	COG3604	Transcriptional regulator
HRD69_15690	COG0426	domain, Protein
HRD69_15690	COG1773	rubredoxin
HRD69_15695	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRD69_15705	COG1522	sequence-specific DNA binding
HRD69_15735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HRD69_15750	COG0583	DNA-binding transcription factor activity
HRD69_15755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRD69_15780	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRD69_15790	COG0076	glutamate decarboxylase activity
HRD69_15795	COG0531	amino acid
HRD69_15805	COG1011	Hydrolase
HRD69_15820	COG1028	Short-chain dehydrogenase reductase Sdr
HRD69_15830	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HRD69_15840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRD69_15845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRD69_15850	COG0589	response to stress
HRD69_15855	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HRD69_15860	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HRD69_15870	COG0531	amino acid
HRD69_15880	COG0745	RESPONSE REGULATOR receiver
HRD69_15885	COG2205	protein histidine kinase activity
HRD69_15890	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HRD69_15900	COG3591	Belongs to the peptidase S1B family
HRD69_15915	COG1643	Atp-dependent helicase
HRD69_15920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRD69_15945	COG3423	Transcriptional regulator
HRD69_15955	COG3784	Protein of unknown function (DUF1318)
HRD69_15965	COG2911	Protein conserved in bacteria
HRD69_15970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRD69_15975	COG3042	response to heat
HRD69_15980	COG1285	pathogenesis
HRD69_15990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRD69_15990	COG1013	pyruvate-flavodoxin oxidoreductase activity
HRD69_15990	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRD69_15990	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRD69_16000	COG0037	tRNA processing
HRD69_16015	COG4166	transmembrane transport
HRD69_16020	COG2866	Carboxypeptidase
HRD69_16025	COG4948	Mandelate Racemase Muconate Lactonizing
HRD69_16030	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HRD69_16040	COG5642	Protein of unknown function (DUF2384)
HRD69_16045	COG5654	RES domain protein
HRD69_16050	COG3768	UPF0283 membrane protein
HRD69_16055	COG3106	COG3106 Predicted ATPase
HRD69_16065	COG1983	PspC domain protein
HRD69_16075	COG1842	Phage shock protein A
HRD69_16080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HRD69_16090	COG4168	peptide transport system, permease
HRD69_16095	COG4171	peptide transport system, permease
HRD69_16105	COG4172	Belongs to the ABC transporter superfamily
HRD69_16110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD69_16110	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRD69_16115	COG3104	oligopeptide transport
HRD69_16135	COG0625	glutathione transferase activity
HRD69_16145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRD69_16155	COG3895	Periplasmic Protein
HRD69_16160	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HRD69_16165	COG3133	Outer membrane lipoprotein
HRD69_16170	COG1846	Transcriptional regulator
HRD69_16180	COG1566	PFAM secretion protein HlyD family protein
HRD69_16190	COG4989	oxidoreductase activity
HRD69_16195	COG3313	Fe-S protein
HRD69_16200	COG2194	sulfuric ester hydrolase activity
HRD69_16205	COG1309	transcriptional regulator
HRD69_16210	COG1902	pentaerythritol trinitrate reductase activity
HRD69_16215	COG0346	lactoylglutathione lyase activity
HRD69_16220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRD69_16225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HRD69_16230	COG0791	NLP P60 protein
HRD69_16245	COG1609	Transcriptional regulator
HRD69_16250	COG0583	DNA-binding transcription factor activity
HRD69_16255	COG2814	Major facilitator Superfamily
HRD69_16260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRD69_16265	COG0307	riboflavin synthase, alpha
HRD69_16270	COG0534	Mate efflux family protein
HRD69_16295	COG1388	LysM domain
HRD69_16295	COG1376	ErfK ybiS ycfS ynhG family protein
HRD69_16300	COG2166	iron-sulfur cluster assembly
HRD69_16310	COG0719	Fe-S assembly protein
HRD69_16315	COG0396	ATPase activity
HRD69_16320	COG0719	Fe-S assembly protein
HRD69_16325	COG0316	Belongs to the HesB IscA family
HRD69_16330	COG2050	protein possibly involved in aromatic compounds catabolism
HRD69_16335	COG0277	FAD linked oxidase domain protein
HRD69_16335	COG0247	lactate metabolic process
HRD69_16340	COG0628	permease
HRD69_16350	COG0574	Belongs to the PEP-utilizing enzyme family
HRD69_16350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRD69_16355	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HRD69_16370	COG4771	TonB-dependent receptor
HRD69_16380	COG0095	Lipoate-protein ligase
HRD69_16385	COG0791	NLP P60 protein
HRD69_16390	COG2076	Multidrug Resistance protein
HRD69_16395	COG2076	Multidrug Resistance protein
HRD69_16400	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRD69_16405	COG0726	polysaccharide deacetylase
HRD69_16415	COG0463	Glycosyl transferase, family 2
HRD69_16420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRD69_16425	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HRD69_16430	COG0386	Belongs to the glutathione peroxidase family
HRD69_16435	COG4139	cobalamin transport
HRD69_16440	COG2186	Transcriptional regulator
HRD69_16445	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRD69_16450	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HRD69_16465	COG2983	Belongs to the UPF0260 family
HRD69_16470	COG0179	Fumarylacetoacetate (FAA) hydrolase
HRD69_16480	COG0850	regulation of cytokinetic process
HRD69_16485	COG2894	cell division
HRD69_16490	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HRD69_16495	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRD69_16500	COG0318	PFAM AMP-dependent synthetase and ligase
HRD69_16505	COG3065	identical protein binding
HRD69_16515	COG1199	ATP-dependent helicase activity
HRD69_16520	COG0251	oxidation-reduction process
HRD69_16525	COG2076	Multidrug Resistance protein
HRD69_16530	COG2076	Multidrug Resistance protein
HRD69_16535	COG3397	chitin binding
HRD69_16540	COG0800	Aldolase
HRD69_16545	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRD69_16550	COG1737	Transcriptional regulator
HRD69_16555	COG0469	pyruvate kinase activity
HRD69_16560	COG1560	Kdo2-lipid A biosynthetic process
HRD69_16565	COG0739	heme binding
HRD69_16570	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HRD69_16575	COG1121	(ABC) transporter
HRD69_16580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRD69_16585	COG2255	four-way junction helicase activity
HRD69_16590	COG0632	four-way junction helicase activity
HRD69_16600	COG0217	transcriptional regulatory protein
HRD69_16605	COG0494	nUDIX hydrolase
HRD69_16610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRD69_16615	COG1335	isochorismatase
HRD69_16620	COG1801	Protein of unknown function DUF72
HRD69_16625	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HRD69_16645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD69_16650	COG3142	Participates in the control of copper homeostasis
HRD69_16655	COG3102	Protein conserved in bacteria
HRD69_16660	COG0018	arginyl-trna synthetase
HRD69_16670	COG0673	inositol 2-dehydrogenase activity
HRD69_16680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD69_16685	COG0477	Major facilitator Superfamily
HRD69_16695	COG3381	protein complex oligomerization
HRD69_16705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRD69_16720	COG3706	GGDEF domain
HRD69_16725	COG0659	secondary active sulfate transmembrane transporter activity
HRD69_16730	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HRD69_16745	COG2890	protein-(glutamine-N5) methyltransferase activity
HRD69_16755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HRD69_16760	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HRD69_16770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRD69_16780	COG0193	aminoacyl-tRNA hydrolase activity
HRD69_16790	COG0012	GTP binding
HRD69_16825	COG0656	L-ascorbic acid biosynthetic process
HRD69_16830	COG4942	peptidase
HRD69_16840	COG3443	Belongs to the bacterial solute-binding protein 9 family
HRD69_16845	COG4211	Belongs to the binding-protein-dependent transport system permease family
HRD69_16850	COG1129	ABC transporter
HRD69_16875	COG1228	amidohydrolase
HRD69_16890	COG2988	succinylglutamate desuccinylase activity
HRD69_16895	COG3724	N-succinylarginine dihydrolase activity
HRD69_16905	COG3138	arginine N-succinyltransferase
HRD69_16910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRD69_16915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRD69_16920	COG1271	oxidase subunit
HRD69_16925	COG1294	oxidase, subunit
HRD69_16935	COG3850	Histidine kinase
HRD69_16940	COG0583	DNA-binding transcription factor activity
HRD69_16950	COG0387	Pfam Sodium calcium exchanger
HRD69_16955	COG1702	phosphate starvation-inducible protein PhoH
HRD69_16965	COG3658	cytochrome
HRD69_16970	COG1215	transferase activity, transferring glycosyl groups
HRD69_16975	COG1649	PFAM Uncharacterised BCR, COG1649
HRD69_16975	COG0726	polysaccharide deacetylase
HRD69_16980	COG0457	Tetratricopeptide repeat
HRD69_17005	COG0577	efflux transmembrane transporter activity
HRD69_17005	COG1136	(ABC) transporter
HRD69_17015	COG0577	efflux transmembrane transporter activity
HRD69_17015	COG1136	(ABC) transporter
HRD69_17030	COG0672	)-iron permease
HRD69_17040	COG1447	Phosphotransferase system cellobiose-specific component IIA
HRD69_17045	COG2723	6-phospho-beta-galactosidase activity
HRD69_17050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD69_17055	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD69_17060	COG1609	Transcriptional regulator
HRD69_17075	COG2066	Belongs to the glutaminase family
HRD69_17080	COG3290	protein histidine kinase activity
HRD69_17085	COG4565	transcriptional regulatory protein
HRD69_17090	COG3493	citrate carrier protein
HRD69_17105	COG2223	nitrite transmembrane transporter activity
HRD69_17110	COG0561	phosphatase activity
HRD69_17135	COG0538	isocitrate dehydrogenase activity
HRD69_17140	COG1187	pseudouridine synthase activity
HRD69_17150	COG0482	sulfurtransferase activity
HRD69_17155	COG2915	High frequency lysogenization protein hflD homolog
HRD69_17160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRD69_17165	COG0745	RESPONSE REGULATOR receiver
HRD69_17175	COG2850	peptidyl-arginine hydroxylation
HRD69_17190	COG1940	carbohydrate kinase activity
HRD69_17195	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRD69_17205	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRD69_17210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HRD69_17215	COG3134	Outer membrane lipoprotein
HRD69_17220	COG1252	NADH dehydrogenase
HRD69_17225	COG3150	esterase
HRD69_17235	COG0510	thiamine kinase activity
HRD69_17240	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HRD69_17245	COG5633	Lipoprotein
HRD69_17250	COG0537	adenosine 5'-monophosphoramidase activity
HRD69_17255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRD69_17270	COG0641	radical SAM
HRD69_17300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD69_17300	COG1263	PTS System
HRD69_17305	COG0084	hydrolase, TatD family'
HRD69_17310	COG0470	DNA polymerase III
HRD69_17315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRD69_17320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRD69_17325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRD69_17330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD69_17340	COG1028	Short-chain dehydrogenase reductase Sdr
HRD69_17355	COG0416	fatty acid biosynthetic process
HRD69_17360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRD69_17365	COG1399	metal-binding, possibly nucleic acid-binding protein
HRD69_17370	COG0424	maF-like protein
HRD69_17375	COG0564	pseudouridine synthase activity
HRD69_17380	COG1530	ribonuclease E activity
HRD69_17380	COG1530	ribonuclease E activity
HRD69_17385	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HRD69_17390	COG0418	dihydroorotase activity
HRD69_17420	COG0628	permease
HRD69_17435	COG1560	Kdo2-lipid A biosynthetic process
HRD69_17440	COG2259	Doxx family
HRD69_17445	COG2814	Major facilitator Superfamily
HRD69_17450	COG3104	oligopeptide transport
HRD69_17460	COG2943	transferase activity, transferring hexosyl groups
HRD69_17465	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HRD69_17480	COG3263	regulation of cellular component size
HRD69_17490	COG3916	Acyl-homoserine-lactone synthase
HRD69_17495	COG2771	luxR family
HRD69_17505	COG3088	subunit of a heme lyase
HRD69_17510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD69_17515	COG1138	Cytochrome C-type biogenesis protein
HRD69_17520	COG3301	Polysulphide reductase, NrfD
HRD69_17525	COG0437	4 iron, 4 sulfur cluster binding
HRD69_17530	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HRD69_17540	COG2375	cellular response to nickel ion
HRD69_17705	COG2885	chlorophyll binding
HRD69_17705	COG3047	cAMP biosynthetic process
HRD69_17735	COG2920	part of a sulfur-relay system
HRD69_17740	COG1254	Belongs to the acylphosphatase family
HRD69_17750	COG3785	DNA binding
HRD69_17755	COG1832	CoA-binding protein
HRD69_17765	COG1803	Methylglyoxal synthase
HRD69_17770	COG0210	DNA helicase
HRD69_17775	COG3304	Inner membrane component domain
HRD69_17780	COG1289	transmembrane transporter activity
HRD69_17785	COG3070	regulator of competence-specific genes
HRD69_17790	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
HRD69_17800	COG3120	sequence-specific DNA binding
HRD69_17805	COG1067	ATP-dependent peptidase activity
HRD69_17810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRD69_17820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRD69_17825	COG3130	regulation of translation
HRD69_17830	COG3009	Protein conserved in bacteria
HRD69_17835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRD69_17835	COG3008	intermembrane lipid transfer
HRD69_17840	COG2995	paraquat-inducible protein a
HRD69_17845	COG0488	(ABC) transporter
HRD69_17850	COG0116	Belongs to the methyltransferase superfamily
HRD69_17850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRD69_17855	COG0633	Ferredoxin
HRD69_17855	COG3217	Mosc domain protein beta barrel domain protein
HRD69_17865	COG0167	dihydroorotate dehydrogenase activity
HRD69_17870	COG0308	aminopeptidase N
HRD69_17875	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HRD69_17880	COG0017	Asparaginyl-tRNA synthetase
HRD69_17890	COG1448	Aminotransferase
HRD69_17895	COG2200	EAL domain
HRD69_17900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRD69_17905	COG3108	Peptidase M15
HRD69_17910	COG2989	Protein conserved in bacteria
HRD69_17925	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HRD69_17930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRD69_17935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HRD69_17940	COG3173	Aminoglycoside phosphotransferase
HRD69_17950	COG2835	tetraacyldisaccharide 4'-kinase activity
HRD69_17955	COG1278	Cold shock
HRD69_17960	COG5383	Protein conserved in bacteria
HRD69_17965	COG1663	tetraacyldisaccharide 4'-kinase activity
HRD69_17975	COG2333	competence protein COMEC
HRD69_17975	COG0658	competence protein
HRD69_17980	COG0776	regulation of translation
HRD69_17985	COG0539	negative regulation of cytoplasmic translation
HRD69_17990	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HRD69_17995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRD69_18005	COG0252	asparaginase activity
HRD69_18010	COG1944	ATP diphosphatase activity
HRD69_18015	COG2116	formate transmembrane transporter activity
HRD69_18020	COG1882	Formate acetyltransferase
HRD69_18025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRD69_18030	COG2814	Major facilitator Superfamily
HRD69_18035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRD69_18040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRD69_18045	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HRD69_18050	COG1674	ftsk spoiiie
HRD69_18050	COG3107	peptidoglycan biosynthetic process
HRD69_18060	COG0492	ferredoxin-NADP+ reductase activity
HRD69_18065	COG4988	ABC transporter
HRD69_18070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HRD69_18075	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HRD69_18080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRD69_18085	COG0542	response to heat
HRD69_18090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRD69_18095	COG1278	Cold shock
HRD69_18105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD69_18110	COG2990	Protein conserved in bacteria
HRD69_18115	COG3593	DNA synthesis involved in DNA repair
HRD69_18120	COG2431	L-lysine efflux transmembrane transporter activity
HRD69_18125	COG1151	hydroxylamine reductase activity
HRD69_18130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD69_18135	COG0028	Belongs to the TPP enzyme family
HRD69_18140	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HRD69_18145	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HRD69_18150	COG0702	epimerase
HRD69_18155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRD69_18165	COG1605	Chorismate mutase
HRD69_18170	COG1126	abc transporter atp-binding protein
HRD69_18175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD69_18180	COG4215	(ABC) transporter
HRD69_18185	COG4160	amino acid transport
HRD69_18190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRD69_18205	COG1177	transmembrane transport
HRD69_18210	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRD69_18215	COG3842	ATPase activity
HRD69_18220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HRD69_18240	COG2985	domain, Protein
HRD69_18240	COG0569	domain protein
HRD69_18250	COG0671	phosphoesterase, PA-phosphatase related
HRD69_18255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRD69_18260	COG1349	DNA-binding transcription factor activity
HRD69_18265	COG0814	amino acid
HRD69_18270	COG1760	l-serine dehydratase
HRD69_18275	COG1686	Belongs to the peptidase S11 family
HRD69_18285	COG0626	cystathionine gamma-synthase activity
HRD69_18295	COG2011	ABC-type metal ion transport system permease component
HRD69_18305	COG1464	Belongs to the NlpA lipoprotein family
HRD69_18320	COG0625	glutathione transferase activity
HRD69_18325	COG4771	TonB-dependent receptor
HRD69_18330	COG0833	amino acid
HRD69_18335	COG0583	DNA-binding transcription factor activity
HRD69_18345	COG2855	membrane
HRD69_18350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HRD69_18355	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HRD69_18355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRD69_18355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRD69_18360	COG1105	Belongs to the carbohydrate kinase PfkB family
HRD69_18370	COG1051	belongs to the nudix hydrolase family
HRD69_18375	COG3005	denitrification pathway
HRD69_18380	COG0243	molybdopterin cofactor binding
HRD69_18395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRD69_18405	COG0246	Mannitol dehydrogenase
HRD69_18410	COG2186	Transcriptional regulator
HRD69_18415	COG0523	cobalamin synthesis protein
HRD69_18420	COG0671	phosphoesterase, PA-phosphatase related
HRD69_18425	COG0791	NLP P60 protein
HRD69_18430	COG2200	EAL domain
HRD69_18435	COG4166	transmembrane transport
HRD69_18440	COG4174	ABC transporter (Permease)
HRD69_18445	COG4239	(ABC) transporter, permease
HRD69_18450	COG4172	Belongs to the ABC transporter superfamily
HRD69_18460	COG2814	Major facilitator Superfamily
HRD69_18465	COG1187	pseudouridine synthase activity
HRD69_18470	COG1061	Type III restriction enzyme res subunit
HRD69_18480	COG3081	Nucleoid-associated protein
HRD69_18485	COG3082	Protein of unknown function (DUF1414)
HRD69_18550	COG3423	Transcriptional regulator
HRD69_18565	COG2723	6-phospho-beta-galactosidase activity
HRD69_18570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD69_18570	COG1263	PTS System
HRD69_18570	COG2190	(PTS) system
HRD69_18575	COG1737	Transcriptional regulator
HRD69_18590	COG3299	homolog of phage Mu protein gp47
HRD69_18630	COG4386	tail sheath protein
HRD69_18645	COG3772	lysozyme
HRD69_18695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HRD69_18700	COG2062	phosphohistidine phosphatase, SixA
HRD69_18705	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRD69_18705	COG1024	Enoyl-CoA hydratase
HRD69_18710	COG0183	Belongs to the thiolase family
HRD69_18715	COG3691	Protein conserved in bacteria
HRD69_18740	COG3088	subunit of a heme lyase
HRD69_18740	COG4235	cytochrome complex assembly
HRD69_18745	COG3088	subunit of a heme lyase
HRD69_18745	COG4235	cytochrome complex assembly
HRD69_18750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRD69_18755	COG1138	Cytochrome C-type biogenesis protein
HRD69_18760	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HRD69_18765	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD69_18770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD69_18775	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRD69_18785	COG2116	formate transmembrane transporter activity
HRD69_18815	COG2824	Alkylphosphonate utilization operon protein PhnA
HRD69_18825	COG1695	Transcriptional regulator
HRD69_18835	COG2723	6-phospho-beta-galactosidase activity
HRD69_18840	COG1263	PTS System
HRD69_18840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD69_18845	COG1609	Transcriptional regulator
HRD69_18850	COG2353	YceI-like domain
HRD69_18855	COG3038	cytochrome b561
HRD69_18870	COG1127	ABC transporter
HRD69_18875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRD69_18900	COG0531	amino acid
HRD69_18905	COG2951	lytic endotransglycosylase activity
HRD69_18920	COG2831	hemolysin activation secretion protein
HRD69_18945	COG0243	molybdopterin cofactor binding
HRD69_18950	COG0437	4 iron, 4 sulfur cluster binding
HRD69_18955	COG3302	dmso reductase anchor subunit
HRD69_18985	COG1598	PFAM Uncharacterised protein family UPF0150
HRD69_18995	COG3038	cytochrome b561
HRD69_19000	COG0436	Aminotransferase
HRD69_19015	COG3275	phosphorelay sensor kinase activity
HRD69_19020	COG3279	Response regulator of the LytR AlgR family
HRD69_19025	COG2223	nitrite transmembrane transporter activity
HRD69_19030	COG0837	glucose binding
HRD69_19045	COG3961	Belongs to the TPP enzyme family
HRD69_19050	COG0667	Aldo Keto reductase
HRD69_19060	COG1914	H( )-stimulated, divalent metal cation uptake system
HRD69_19065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HRD69_19100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRD69_19125	COG3530	Putative quorum-sensing-regulated virulence factor
HRD69_19130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRD69_19150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD69_19165	COG2205	protein histidine kinase activity
HRD69_19170	COG0745	RESPONSE REGULATOR receiver
HRD69_19175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD69_19235	COG4208	sulfate ABC transporter
HRD69_19240	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HRD69_19260	COG1737	Transcriptional regulator
HRD69_19265	COG2731	YhcH YjgK YiaL family protein
HRD69_19280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD69_19285	COG2837	iron assimilation
HRD69_19295	COG3111	PFAM Bacterial OB fold (BOF) protein
HRD69_19305	COG0456	acetyltransferase
HRD69_19310	COG0408	coproporphyrinogen oxidase activity
HRD69_19315	COG1671	Belongs to the UPF0178 family
HRD69_19330	COG3005	denitrification pathway
HRD69_19335	COG3043	anaerobic respiration
HRD69_19340	COG0243	molybdopterin cofactor binding
HRD69_19345	COG3062	negative regulation of establishment of protein localization
HRD69_19350	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD69_19350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD69_19355	COG2197	response regulator
HRD69_19365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD69_19370	COG3842	ATPase activity
HRD69_19375	COG1175	transmembrane transport
HRD69_19390	COG1393	Belongs to the ArsC family
HRD69_19395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRD69_19400	COG1876	peptidase activity
HRD69_19410	COG0400	carboxylic ester hydrolase activity
HRD69_19415	COG1444	tRNA N-acetyltransferase activity
HRD69_19420	COG2707	UPF0756 membrane protein
HRD69_19425	COG2321	neutral zinc metallopeptidase
HRD69_19430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRD69_19435	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HRD69_19440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRD69_19445	COG2716	regulation of RNA biosynthetic process
HRD69_19450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRD69_19455	COG0628	permease
HRD69_19460	COG4783	chaperone-mediated protein folding
HRD69_19465	COG1393	Belongs to the ArsC family
HRD69_19470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRD69_19475	COG2233	PERMEase
HRD69_19480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRD69_19490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRD69_19495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRD69_19505	COG0581	inorganic phosphate transmembrane transporter activity
HRD69_19510	COG0573	inorganic phosphate transmembrane transporter activity
HRD69_19515	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRD69_19520	COG0248	Ppx GppA phosphatase
HRD69_19530	COG2239	Acts as a magnesium transporter
HRD69_19535	COG5002	protein histidine kinase activity
HRD69_19535	COG5001	Diguanylate cyclase
HRD69_19535	COG3447	MASE1 domain protein
HRD69_19540	COG0443	Heat shock 70 kDa protein
HRD69_19550	COG3121	Chaperone
HRD69_19570	COG3077	Addiction module antitoxin, RelB DinJ family
HRD69_19575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRD69_19585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRD69_19590	COG2205	protein histidine kinase activity
HRD69_19595	COG0745	RESPONSE REGULATOR receiver
HRD69_19600	COG3422	double-strand break repair
HRD69_19620	COG1597	lipid kinase activity
HRD69_19625	COG3730	PTS system glucitol sorbitol-specific
HRD69_19640	COG1028	Short-chain dehydrogenase reductase Sdr
HRD69_19645	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRD69_19650	COG1349	DNA-binding transcription factor activity
HRD69_19670	COG0351	phosphomethylpyrimidine kinase
HRD69_19705	COG5265	(ABC) transporter
HRD69_19710	COG2850	peptidyl-arginine hydroxylation
HRD69_19780	COG3188	usher protein
HRD69_19785	COG3121	Chaperone
HRD69_19845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRD69_19845	COG0519	Catalyzes the synthesis of GMP from XMP
HRD69_19850	COG0516	GMP reductase activity
HRD69_19850	COG0517	IMP dehydrogenase activity
HRD69_19855	COG1570	exodeoxyribonuclease VII activity
HRD69_19860	COG1645	bacterial-type flagellum-dependent swarming motility
HRD69_19870	COG1160	GTP binding
HRD69_19875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD69_19880	COG2976	Protein conserved in bacteria
HRD69_19895	COG1426	Protein conserved in bacteria
HRD69_19920	COG4953	penicillin-binding protein 1C
HRD69_19925	COG2373	Large extracellular alpha-helical protein
HRD69_19935	COG3468	outer membrane autotransporter barrel domain protein
HRD69_19950	COG2975	iron-sulfur cluster assembly
HRD69_19955	COG0633	Ferredoxin
HRD69_19960	COG0443	Heat shock 70 kDa protein
HRD69_19975	COG0822	iron-sulfur transferase activity
HRD69_19985	COG1959	2 iron, 2 sulfur cluster binding
HRD69_19990	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HRD69_19995	COG0483	inositol monophosphate 1-phosphatase activity
HRD69_20000	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HRD69_20005	COG3683	transport system, periplasmic component
HRD69_20010	COG3711	transcriptional antiterminator
HRD69_20015	COG2814	Major facilitator Superfamily
HRD69_20025	COG1017	nitric oxide dioxygenase activity
HRD69_20025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRD69_20030	COG2188	Transcriptional regulator
HRD69_20040	COG3457	Alanine racemase
HRD69_20045	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HRD69_20060	COG0347	Belongs to the P(II) protein family
HRD69_20065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRD69_20065	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRD69_20070	COG2204	response regulator
HRD69_20075	COG3170	Tfp pilus assembly protein FimV
HRD69_20080	COG2205	protein histidine kinase activity
HRD69_20095	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HRD69_20100	COG0590	tRNA wobble adenosine to inosine editing
HRD69_20110	COG0560	Phosphoserine phosphatase
HRD69_20115	COG1263	PTS System
HRD69_20115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRD69_20125	COG1737	Transcriptional regulator
HRD69_20130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRD69_20135	COG2610	gluconate transmembrane transporter activity
HRD69_20140	COG0736	holo-[acyl-carrier-protein] synthase activity
HRD69_20145	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HRD69_20150	COG1381	Involved in DNA repair and RecF pathway recombination
HRD69_20155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRD69_20170	COG0481	GTPase activity
HRD69_20180	COG3086	response to oxidative stress
HRD69_20190	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HRD69_20200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HRD69_20205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HRD69_20210	COG0513	Belongs to the DEAD box helicase family
HRD69_20215	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HRD69_20220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRD69_20225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRD69_20230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRD69_20235	COG0497	DNA recombination
HRD69_20240	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRD69_20250	COG2867	negative regulation of translational initiation
HRD69_20255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRD69_20265	COG0582	viral genome integration into host DNA
HRD69_20275	COG3311	Transcriptional regulator
HRD69_20300	COG0210	DNA helicase
HRD69_20330	COG3596	GTP binding
HRD69_20335	COG2378	regulation of single-species biofilm formation
HRD69_20355	COG2003	Belongs to the UPF0758 family
HRD69_20400	COG0531	amino acid
HRD69_20405	COG3394	polysaccharide catabolic process
HRD69_20410	COG2169	Transcriptional regulator
HRD69_20410	COG1917	Cupin 2, conserved barrel domain protein
HRD69_20415	COG1447	Phosphotransferase system cellobiose-specific component IIA
HRD69_20420	COG2723	6-phospho-beta-galactosidase activity
HRD69_20425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD69_20430	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HRD69_20435	COG0625	glutathione transferase activity
HRD69_20450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRD69_20460	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HRD69_20465	COG4413	Urea transporter
HRD69_20475	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG