locus-tag class description M479_1 ENOG4105HVQ Regulatory factor of maltose metabolism M479_100 ENOG4105BZN citrate synthase M479_1000 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) M479_1001 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) M479_1002 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) M479_1005 ENOG4108V06 Glutathione peroxidase M479_1006 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) M479_101 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit M479_1014 ENOG4108QBX (LipO)protein M479_1017 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) M479_1019 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) M479_102 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein M479_1020 ENOG4105IPI Membrane M479_1021 ENOG4105CQB FAD linked oxidase domain protein M479_1022 ENOG4105KA0 thioesterase Superfamily protein M479_1023 ENOG4108Z4V iron-sulfur cluster assembly M479_1024 ENOG4105DIW FeS assembly protein SUFB M479_1025 ENOG4105C3K feS assembly ATPase SufC M479_1026 ENOG4105JRK feS assembly protein SufD M479_1029 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein M479_1033 ENOG4105KMX major outer membrane lipoprotein M479_1034 ENOG4105CA9 Pyruvate kinase M479_1038 ENOG4108R6K riboflavin synthase, subunit alpha M479_1039 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase M479_104 ENOG4105E33 succinate dehydrogenase M479_1040 ENOG4105CZQ inner membrane transport protein YdhC M479_1041 ENOG4105F52 Transcriptional regulator M479_1044 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) M479_1045 ENOG4105K4H Nlp p60 protein M479_1047 ENOG4105M2J Glutaredoxin M479_1049 ENOG4108UYE Lactoylglutathione lyase M479_105 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 M479_1051 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase M479_1052 ENOG4108WUH Transcriptional regulator, TetR family M479_1053 ENOG4105DIJ Phosphoethanolamine transferase M479_1054 ENOG4105XZD Fe-S protein M479_1055 ENOG4107RGM aldo keto reductase M479_1056 ENOG4108XTF Outer Membrane Lipoprotein M479_1058 ENOG410642K Lysozyme inhibitor M479_106 ENOG4105C7S Dehydrogenase M479_1062 ENOG4108K3A Glutathione S-transferase M479_1063 ENOG4108ZR5 Conserved Protein M479_1064 ENOG41069YE inner membrane protein yohC M479_1065 ENOG4105DUX Transporter M479_1067 ENOG4105Q4T oxidoreductase M479_1068 ENOG4108JQ2 peptide transport system atp-binding protein M479_1069 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein M479_1070 ENOG4108EU3 peptide transport system, permease M479_1071 ENOG4108I5W peptide transport system, permease protein M479_1072 ENOG4108HIY periplasmic M479_1074 ENOG4105E51 psp operon transcriptional activator M479_1075 ENOG41087YS Phage shock protein A M479_1076 ENOG4105YYT phage shock protein B M479_1077 ENOG4105FM1 phage shock protein C M479_1079 ENOG4105CM6 amino acid regulated cytosolic protein M479_108 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha M479_1089 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) M479_109 ENOG4108RS6 transposase M479_1090 ENOG4107S8C mandelate racemase muconate lactonizing M479_1091 ENOG4105KXI murein peptide amidase A M479_1092 ENOG4107QSI ABC, transporter M479_1098 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) M479_11 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) M479_110 ENOG4105C4M (Ubiquinol oxidase) subunit I M479_1100 ENOG4105KT7 mgtC SapB transporter M479_1102 ENOG41090X5 Heat shock protein hslJ M479_1103 ENOG4105C5I Dehydrogenase M479_1104 ENOG4107H52 Dicarboxylate transport M479_1105 ENOG410689M (LipO)protein M479_1106 ENOG4105WXT Conserved Protein M479_1107 ENOG4105DEI Mannitol dehydrogenase M479_1108 ENOG4105DKT Transcriptional regulator M479_111 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii M479_1110 ENOG4105CQ7 ATP-dependent helicase M479_1113 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap M479_1115 ENOG4105DS1 cytochrome b561 M479_1120 ENOG4105CTD carboxy-peptidase M479_1121 ENOG4105JJR Histidine kinase M479_1122 ENOG4107EXC regulatoR M479_1124 ENOG4105D5Q Arginine ornithine antiporter M479_1125 ENOG4105C5D exported protein M479_1126 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) M479_1127 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) M479_1128 ENOG4105Q9Y Universal stress protein M479_1129 ENOG4105DS0 Transcriptional regulator, Crp Fnr family M479_113 ENOG4105KJB cyd operon protein YbgE M479_1130 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) M479_1133 ENOG4105PAD Hydrolase M479_1134 ENOG4105M71 acetolactate synthase 1 regulatory subunit M479_1135 ENOG4105C7K acetolactate synthase M479_114 ENOG4107YD3 Thioesterase M479_1141 ENOG4105FYV Amp nucleosidase M479_1143 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component M479_1144 ENOG4107UWC ABC, transporter M479_1145 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M479_1147 ENOG41060NJ transcriptional regulator M479_1148 ENOG4105KBG Protein of unknown function (DUF1161) M479_1149 ENOG4105CMQ Chloride channel M479_115 ENOG4105E02 MotA TolQ exbB proton channel M479_1150 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) M479_1152 ENOG4105DAG ROK family M479_1153 ENOG4106NZI LysR family Transcriptional regulator M479_1154 ENOG4105D94 Major Facilitator Superfamily M479_1155 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) M479_1156 ENOG4105C9Q fumarate hydratase class II M479_1157 ENOG4105EIP mannose-6-phosphate isomerase M479_1158 ENOG4106J39 exported protein M479_116 ENOG4105M8F Biopolymer transport protein exbD tolR M479_1160 ENOG4105DHU Bile acid M479_1161 ENOG4105D9R oxidoreductase M479_1163 ENOG4105CNN ABC, transporter M479_1164 ENOG4105CNN ABC, transporter M479_1166 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator M479_117 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA M479_117 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA M479_1170 ENOG4108JJA ABC, transporter M479_1171 ENOG4105C42 Type I secretion membrane fusion protein (HlyD M479_1173 ENOG4105BZ1 (ABC) transporter M479_1174 ENOG4108JJA ABC, transporter M479_1175 ENOG4105M9B inner membrane protein ydgK M479_1179 ENOG4105UEI Transcriptional Regulator AraC Family M479_1180 ENOG4105D6A Electron transport complex M479_1181 ENOG4108UQQ Electron transport complex M479_1183 ENOG4105CSM endonuclease III M479_1184 ENOG4105EXW epimerase dehydratase M479_1185 ENOG4105CSP Major Facilitator Superfamily M479_1187 ENOG4105D22 carbon starvation protein M479_1188 ENOG4105VCD cytoplasmic protein M479_1189 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) M479_119 ENOG4105KCK Peptidoglycan-associated lipoprotein M479_1191 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase M479_1193 ENOG4108ZJT translation initiation factor, Sui1 M479_1196 ENOG4105CFV Tetratricopeptide repeat protein M479_1197 ENOG4105Q4A inner membrane protein yciS M479_1198 ENOG4105EYK Phosphatidylglycerophosphatase B M479_1199 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) M479_12 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M479_120 ENOG4105UFD tol-pal system protein YbgF M479_1200 ENOG4107QM5 aconitate hydratase M479_1202 ENOG4107R11 Transcriptional regulator M479_1203 ENOG4108RS6 transposase M479_1204 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) M479_1206 ENOG4105RKX Protein of unknown function (DUF2498) M479_1207 ENOG4105ERU peptidase M479_1208 ENOG4105UBK short-chain dehydrogenase reductase M479_1209 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase M479_1210 ENOG4105FE9 pseudouridine synthase M479_1211 ENOG4107RTD sua5 ycio yrdc ywlc family protein M479_1212 ENOG4105DB7 PHP domain protein M479_1214 ENOG4105DDQ anthranilate synthase M479_1216 ENOG4105DK0 Indole-3-glycerol phosphate synthase M479_1220 ENOG4105EIF outer membrane protein W M479_1225 ENOG4105NAU thioesterase Superfamily protein M479_1227 ENOG410822N TonB family M479_1228 ENOG4105K9H YciI-like protein M479_1231 ENOG4108T1M outer membrane protein x M479_1235 ENOG4108JQ7 (ABC) transporter M479_1236 ENOG4105C3U ABC transporter M479_1237 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M479_1239 ENOG4107QSI ABC, transporter M479_1240 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein M479_1241 ENOG4108EKI Dehydrogenase M479_1242 ENOG4107104 thymidine kinase M479_1245 ENOG4105C6Y Udp-glucose 6-dehydrogenase M479_1246 ENOG4105I93 response regulator M479_1248 ENOG4105CIY formyltetrahydrofolate deformylase M479_1252 ENOG4105SKE transcriptional Regulator LysR family M479_1253 ENOG4105CGK Exodeoxyribonuclease III M479_1254 ENOG4105M6F mutator MutT protein M479_1255 ENOG4105MTM Protein of unknown function (DUF1496) M479_1256 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) M479_1257 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) M479_1258 ENOG41069NU Nitroreductase M479_1259 ENOG4105D07 Signal peptide peptidase, SppA M479_126 ENOG4106Z1T Nicotinamide Mononucleotide Transporter M479_1260 ENOG4105HDK L-asparaginase M479_1261 ENOG4108RWI nicotinamidase M479_1262 ENOG4105VUT cytoplasmic protein M479_1265 ENOG4105DSB aldose 1-epimerase M479_1266 ENOG4105GNX MltA-interacting MipA family protein M479_1267 ENOG4105CYN Serine protein kinase M479_127 ENOG4105PGM cation diffusion facilitator family transporter M479_1270 ENOG4105HEI LysR family (Transcriptional regulator M479_1271 ENOG4105EUB pirin domain protein M479_1272 ENOG4105CNH Multidrug resistance protein MdtL M479_1274 ENOG4105ED1 spovr family M479_128 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) M479_1280 ENOG4105C3J Cysteine desulfurase M479_1282 ENOG4105UZW Tail fiber assembly protein M479_129 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) M479_1298 ENOG4108RS6 transposase M479_13 ENOG4105C2J ABC transporter M479_132 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) M479_1326 ENOG4105HRS Antitermination protein M479_1328 ENOG4105NY2 NinB protein M479_1333 ENOG4107R08 Integrase M479_1335 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase M479_1336 ENOG4105CVE Lytic murein transglycosylase M479_1339 ENOG4107QMS site-determining protein M479_1340 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) M479_1341 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) M479_1342 ENOG4105CEY Amp-dependent synthetase and ligase M479_1343 ENOG4105Y4Z Outer Membrane Lipoprotein M479_1344 ENOG41072GX Peptidase M22 Glycoprotease M479_1345 ENOG4105DVT helicase M479_1346 ENOG4105M4H endoribonuclease L-psp M479_1349 ENOG4108UHU Aldolase M479_135 ENOG4105F0Z galactose-1-phosphate uridylyltransferase M479_1351 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase M479_1352 ENOG4106KNT transcriptional regulator M479_1353 ENOG4105CA9 Pyruvate kinase M479_1354 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase M479_1355 ENOG4105DR5 peptidase M479_1356 ENOG4105NXV High-affinity zinc uptake system protein M479_1358 ENOG4105FAV ABC, transporter M479_136 ENOG4105CMR udp-glucose 4-epimerase M479_1363 ENOG4108TIT dATP pyrophosphohydrolase M479_1365 ENOG41081XQ Conserved Protein M479_1366 ENOG4105WJG Glutathione M479_1370 ENOG4106ZCM YecM protein M479_1374 ENOG4105CJR Integral membrane protein (MviN M479_1375 ENOG4105EP9 oxidoreductase M479_1376 ENOG4105D9U N-acetyltransferase M479_1378 ENOG4105F3T (LipO)protein M479_1379 ENOG4107XHZ cytoplasmic chaperone TorD family protein M479_1382 ENOG4105E2R ROK family M479_1383 ENOG4108QXE glycerophosphoryl diester phosphodiesterase M479_1384 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) M479_1385 ENOG4108RS6 transposase M479_1387 ENOG4105F38 ABC transporter, permease M479_1388 ENOG4105EG2 ABC transporter, permease M479_1392 ENOG4105CHH sulfate transporter M479_1394 ENOG41063JG Transcriptional regulator M479_1395 ENOG4108YY7 Invasion gene expression up-regulator SirB M479_1396 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) M479_14 ENOG4105CNN ABC, transporter M479_140 ENOG4105DKW ABC transporter M479_1401 ENOG4105C5T Phosphoribosyl pyrophosphate synthase M479_1402 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria M479_1404 ENOG4105C3G gtp-binding protein M479_141 ENOG4105F4R Transcriptional regulator mode M479_1413 ENOG4105ENX hydrolase M479_1414 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M479_1418 ENOG4105GR3 Histidine kinase M479_142 ENOG410680R Protein of unknown function (DUF2592) M479_1427 ENOG4108WF3 methyltransferase M479_143 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein M479_144 ENOG4105E0C molybdate abc transporter M479_1441 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase M479_1442 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) M479_1443 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) M479_1445 ENOG41090B9 response to stress M479_1446 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) M479_1447 ENOG4105CZE histidine utilization repressor M479_146 ENOG4108K4B hydrolase M479_1461 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family M479_1462 ENOG4105BZU Histidine kinase M479_1464 ENOG4105EWV Sodium calcium exchanger membrane region M479_1465 ENOG4105D5M phosphate starvation-inducible protein M479_1468 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD M479_1469 ENOG4105CND Glycosyl transferase, family 2 M479_1470 ENOG4107BJW polysaccharide deacetylase M479_1471 ENOG4108TUY outer membrane protein PgaA M479_1472 ENOG4105H1N peptidase, M24 M479_1476 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) M479_1478 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) M479_1481 ENOG4107SJW iron permease, FTR1 M479_1484 ENOG4105CSV Glutaminase M479_1485 ENOG4105MVE transcriptional regulator M479_1486 ENOG4105C85 amino acid M479_1487 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family M479_1488 ENOG4106MMI NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) M479_1491 ENOG4107RGD Major Facilitator superfamily M479_1496 ENOG4105DJG MaoC domain protein dehydratase M479_1497 ENOG4105CYC Transferase M479_1499 ENOG4108Q9V regulatoR M479_15 ENOG4105CK5 oxidoreductase M479_1500 ENOG4105BZU Histidine kinase M479_1503 ENOG4105CW0 outer membrane usher protein M479_1505 ENOG4108MQF Chaperone M479_151 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) M479_1511 ENOG4105EYM Major Facilitator superfamily M479_1512 ENOG4105BZ1 (ABC) transporter M479_1515 ENOG4105C0W non-ribosomal peptide synthetase M479_1519 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase M479_152 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) M479_1520 ENOG4107ZSV Receptor M479_153 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) M479_1532 ENOG4108IJ9 (ABC) transporter M479_1533 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component M479_1536 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) M479_1537 ENOG4105FDP GntR family transcriptional regulator M479_154 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) M479_155 ENOG4105VYA Uncharacterized conserved protein (DUF2132) M479_1556 ENOG4108WC9 type VI secretion system effector, hcp1 family M479_156 ENOG4105CHW UPF0052 protein M479_1567 ENOG4105WH1 Two component transcriptional regulator luxr family M479_1568 ENOG4105XVG cytoplasmic protein M479_1569 ENOG4105RA2 Membrane M479_1571 ENOG4108T1M outer membrane protein x M479_1573 ENOG4105C85 amino acid M479_1576 ENOG4105DBE peroxidase M479_1579 ENOG4105CK7 Sodium proline symporter M479_158 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) M479_1581 ENOG4105C26 Dehydrogenase M479_1584 ENOG4105CDA abc transporter atp-binding protein M479_1585 ENOG4105E5Q amino acid AbC transporter M479_1586 ENOG4105EAB amino acid AbC transporter M479_1587 ENOG4105EAB amino acid AbC transporter M479_1588 ENOG4105K6H D-cysteine desulfhydrase M479_1589 ENOG4108M9K flagella biosynthesis protein FliZ M479_1590 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M479_1591 ENOG4105I03 Flagellin M479_1592 ENOG4105DTS flagellar hook-associated M479_1593 ENOG4105MQ3 flagellar protein FliS M479_1596 ENOG4105DHT Metal Dependent Phosphohydrolase M479_16 ENOG4105EDK PfkB domain protein M479_160 ENOG4105M00 molybdopterin converting factor, subunit 1 M479_1600 ENOG4105VQ0 flagellar hook-basal body complex protein fliE M479_1601 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) M479_1602 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) M479_1603 ENOG41090PJ Flagellar assembly protein M479_1604 ENOG4108JIR Flagellum-specific ATP synthase M479_1605 ENOG4105GSA Flagellar export protein flij M479_1606 ENOG4105WF4 Flagellar hook-length control protein M479_1607 ENOG4107ZI8 flagellar basal body-associated protein flil M479_1608 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) M479_1609 ENOG4105DD5 Flagellar motor switch protein M479_161 ENOG4108ZAF Molybdopterin M479_1611 ENOG4105CN7 Flagellar biosynthetic protein FliP M479_1612 ENOG4105VS8 Flagellar biosynthetic protein fliq M479_1613 ENOG4105D19 Role in flagellar biosynthesis (By similarity) M479_1616 ENOG4108MGF sugar kinase M479_1617 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane M479_1618 ENOG4105C2J ABC transporter M479_162 ENOG4105HFZ Membrane M479_1620 ENOG4105CNN ABC, transporter M479_1622 ENOG4105DKT Transcriptional regulator M479_1623 ENOG4105DTJ flagellar hook-associated protein M479_1624 ENOG4105E1Q flagellar hook-associated protein M479_1625 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj M479_1628 ENOG4105CGA flagellar basal-body rod protein FlgG M479_1629 ENOG4108KPB Flagellar basal-body rod protein FlgF M479_163 ENOG4108RS6 transposase M479_1630 ENOG4105BZE flagellar hook protein, FlgE M479_1631 ENOG4105W00 Flagellar hook capping protein M479_1632 ENOG4108ZC9 flagellar basal-body rod protein flgc M479_1633 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) M479_1634 ENOG4105CKS Flagella basal body P-ring formation protein flgA M479_1635 ENOG4105M9M anti-sigma28 factor FlgM M479_1636 ENOG4105QVD Flagella synthesis protein FlgN M479_1640 ENOG4105W13 flagellar protein M479_1641 ENOG4105D7B Flagellar biosynthesis protein flha M479_1642 ENOG4105D00 flagellar biosynthetic protein flhB M479_1645 ENOG4105NKT exported protein M479_1647 ENOG4105FXM Copper resistance protein M479_1648 ENOG41090A1 ferritin M479_1649 ENOG4105MPK DNA polymerase III subunit theta M479_1651 ENOG4105CUG Oligopeptidase b M479_1654 ENOG4105X2V dna damage-inducible protein M479_1655 ENOG4105C1J atp-dependent rna helicase M479_1658 ENOG4105CRQ synthase (Component I) M479_1660 ENOG4105EJQ L-serine dehydratase M479_1661 ENOG4107UWN reductase M479_1662 ENOG4105EFA 4-hydroxyphenylacetate M479_1667 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase M479_1668 ENOG4105C26 Dehydrogenase M479_167 ENOG4105C94 Transporter M479_1671 ENOG4108V8F Transcriptional regulator, MarR family M479_1672 ENOG4105EE5 Membrane protein terC M479_1673 ENOG4108EQA pts system M479_1674 ENOG4105ETZ PTS System M479_1675 ENOG4105F3R pts system mannose fructose sorbose family iid M479_1679 ENOG4105BZU Histidine kinase M479_168 ENOG4105CN8 Transcriptional regulator M479_1681 ENOG4105DHI Methyltransferase M479_1682 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase M479_1683 ENOG4105VEQ Cold shock protein M479_1686 ENOG4105C85 amino acid M479_1689 ENOG41064PC M479_1690 ENOG4105TIK M479_1691 ENOG4105N4N Protein of unknown function (DUF2766) M479_1695 ENOG4105BZ1 (ABC) transporter M479_1696 ENOG4108RS6 transposase M479_170 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) M479_1702 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) M479_1706 ENOG4108TSE Transferase M479_1707 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit M479_1709 ENOG4105CG6 trap dicarboxylate transporter dctm subunit M479_171 ENOG4105EAA nucleoside M479_1710 ENOG4108KX4 response regulator M479_1712 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme M479_1716 ENOG4105UQX Mate efflux family protein M479_1720 ENOG4105DIA mandelate racemase muconate lactonizing M479_1722 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr M479_1723 ENOG4105KIR Thiol-disulfide oxidoreductase dcc M479_1724 ENOG4105CSP Major Facilitator Superfamily M479_1726 ENOG4105TNG K13735 adhesin invasin M479_1729 ENOG4105CJB Exodeoxyribonuclease I M479_1730 ENOG4105CUB amino acid M479_1732 ENOG4107SCQ Iron-containing alcohol dehydrogenase M479_1733 ENOG4105C2J ABC transporter M479_1735 ENOG4105CNN ABC, transporter M479_1737 ENOG4108535 NAD dependent epimerase/dehydratase family M479_1739 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) M479_174 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) M479_1741 ENOG4105ECC imidazole-glycerol-phosphate dehydratase M479_1742 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) M479_1745 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase M479_1746 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) M479_1747 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase M479_1748 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase M479_1749 ENOG4105DUU IucA IucC family protein M479_1750 ENOG4105CNM Receptor M479_1751 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) M479_1752 ENOG4105DQ5 transport system permease protein M479_1753 ENOG4105TVJ transport system, permease M479_1754 ENOG4105E0A ABC, transporter M479_1755 ENOG4105DUU IucA IucC family protein M479_1757 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) M479_1758 ENOG4105DY8 decarboxylase M479_1759 ENOG4108819 ferric iron reductase M479_176 ENOG41061WM D-Alanyl-D-Alanine M479_1760 ENOG4105EE5 Membrane protein terC M479_1761 ENOG4108GAE asmA family M479_1764 ENOG4105D1F ATP-binding protein M479_1766 ENOG4108RS6 transposase M479_177 ENOG4105CXG d-lactate dehydrogenase M479_1770 ENOG4105E5W Transporter M479_1772 ENOG41067MG lrgb family M479_1775 ENOG4107GZ4 SanA protein M479_1776 ENOG4107SDZ Galactoside transport system permease protein mglC M479_1778 ENOG4108HWV )-transporter M479_1781 ENOG4105DHF Membrane M479_1783 ENOG4105CBP Major Facilitator M479_1784 ENOG4105EGI Transcriptional regulator M479_1789 ENOG4105ENT Efflux transporter rnd family, mfp subunit M479_179 ENOG4105N1F Hnh endonuclease M479_1790 ENOG4105C19 ABC transporter M479_1792 ENOG4105CVM Molybdenum cofactor synthesis domain protein M479_1793 ENOG4105D06 uba thif-type nad fad binding protein M479_1795 ENOG4105C5H ABC transporter M479_18 ENOG4105DH8 myo-inositol catabolism M479_181 ENOG4105Y3U Transglycosylase-associated protein M479_1814 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M479_1816 ENOG4105CDV Ompa motb domain protein M479_1822 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase M479_1823 ENOG41062T2 Acyl carrier protein M479_1825 ENOG4105CHR reductase M479_1826 ENOG4108KQ6 Enoyl-CoA hydratase M479_1828 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase M479_1829 ENOG4105CHR reductase M479_183 ENOG4106ZX3 phosphonate ABC transporter, periplasmic phosphonate-binding protein M479_1830 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) M479_1831 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) M479_1838 ENOG4108BUD transposase M479_1840 ENOG4108Z0T Part of a sulfur-relay system (By similarity) M479_1844 ENOG4105K4P CoA-binding domain protein M479_1845 ENOG4108Q67 UPF0319 protein M479_1847 ENOG41088T4 Helicase IV M479_1848 ENOG410901E Membrane M479_1849 ENOG4105EM2 membrane M479_1850 ENOG4108RZ1 DNA transformation protein M479_1852 ENOG4105UYK outer membrane protein a M479_1853 ENOG4108RS6 transposase M479_1855 ENOG4105DAN ATP-dependent protease M479_1858 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) M479_186 ENOG4108W15 Protein of unknown function (DUF1456) M479_1860 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) M479_1861 ENOG4108RS6 transposase M479_1863 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) M479_1867 ENOG4105C3F Signal peptidase i M479_1870 ENOG4105WMJ Positive regulator of sigma E, RseC MucC M479_1871 ENOG4105VQK sigma E regulatory protein, MucB RseB M479_1872 ENOG41069PW sigma-e factor negative regulatory protein M479_1874 ENOG4108IYU L-aspartate oxidase M479_1876 ENOG4105C1J atp-dependent rna helicase M479_188 ENOG4105C32 Amino acid ABC transporter (Permease) M479_1887 ENOG4107R7A Allophanate hydrolase subunit 2 M479_1888 ENOG4105P4J Allophanate hydrolase, subunit 1 M479_189 ENOG4105CNN ABC, transporter M479_1890 ENOG4107QNR UPF0135 protein M479_1891 ENOG4107RF4 Phosphodiesterase M479_1892 ENOG4105CVP deoxyribo-dipyrimidine photolyase M479_1893 ENOG4107SEY Conserved Protein M479_1894 ENOG4105XIQ Protein of unknown function (DUF2517) M479_1898 ENOG4105C08 Histidine kinase M479_1899 ENOG4105C08 Histidine kinase M479_190 ENOG4108JJB ABC transporter M479_1900 ENOG4105EEX Two component transcriptional regulator (Winged helix family M479_1904 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 M479_1909 ENOG4105EZV Transcriptional regulator M479_191 ENOG4108IV0 ABC, transporter M479_1910 ENOG4105VCP PTS System M479_1911 ENOG4105CK1 PTS System M479_1912 ENOG4105VZJ PTS System M479_1913 ENOG41085Q9 Protein CrcB homolog M479_1914 ENOG41086WQ Protein CrcB homolog M479_1915 ENOG4107SVH Potassium channel protein M479_1916 ENOG4105XXV Acid-resistance protein M479_1920 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) M479_1927 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) M479_1928 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) M479_1929 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M479_1930 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M479_1931 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein M479_1932 ENOG4105VEQ Cold shock protein M479_1934 ENOG4108SAJ Protein of unknown function (DUF1198) M479_1935 ENOG4108WMJ Protein of unknown function (DUF2002) M479_194 ENOG4105KHC sulfurtransferase M479_1940 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M479_1941 ENOG4108IJ7 Glycine betaine M479_1942 ENOG4108HQS Glycine betaine M479_1943 ENOG4105GIJ Glycine betaine M479_1945 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease M479_1947 ENOG4108JDX DNA polymerase iii, epsilon subunit M479_1949 ENOG4105D1A Methyltransferase M479_195 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system M479_1951 ENOG4105E9H Lytic Murein transglycosylase M479_1954 ENOG4105CV8 reductase M479_196 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component M479_1960 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase M479_1962 ENOG4108UMI ABC transporter, permease M479_1963 ENOG4105D01 (LipO)protein M479_1964 ENOG4108R8X outer membrane lipoprotein M479_1965 ENOG4108R96 Methyltransferase, YaeB family M479_1967 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion M479_1968 ENOG4108YZN class I peptide chain release factor M479_1969 ENOG4108VWS Yaeq family M479_197 ENOG4108IJ8 ABC transporter M479_1971 ENOG4105M1T rho-binding antiterminator M479_1973 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) M479_1974 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase M479_1976 ENOG4105C0B DNA polymerase III (alpha subunit) M479_1978 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) M479_198 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component M479_1982 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) M479_1984 ENOG4105DZP Membrane-associated zinc metalloprotease M479_1985 ENOG4105KNE Phosphatidate cytidylyltransferase M479_1986 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) M479_199 ENOG4105D5Q Arginine ornithine antiporter M479_1992 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) M479_1996 ENOG4105QDK Flavodoxin M479_1997 ENOG4105DR9 pseudouridine synthase M479_1998 ENOG4105WP7 tRNA pseudouridine synthase C M479_1999 ENOG4108RS6 transposase M479_2 ENOG4108JQB penicillin-binding protein 1C M479_20 ENOG4108JJ7 ABC transporter M479_200 ENOG4105CXN decarboxylase M479_2002 ENOG4105EWT decarboxylase family M479_2003 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease M479_2005 ENOG4105M08 Membrane M479_2006 ENOG4105ETT transcriptional Regulator, LysR family M479_2008 ENOG4105C9B Cysteine desulfurase M479_2009 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) M479_2010 ENOG4105CUZ uba thif-type nad fad binding protein M479_2011 ENOG4105CA3 membrane-bound lytic murein transglycosylase M479_2014 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M479_2015 ENOG4107QZM n-acetylglutamate synthase M479_2019 ENOG4107QYX exodeoxyribonuclease v alpha M479_202 ENOG4105CXN decarboxylase M479_2020 ENOG4107QKA exodeoxyribonuclease V beta M479_2021 ENOG4107QXK peptidase M479_2022 ENOG4105DSY exodeoxyribonuclease V, gamma M479_2030 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase M479_2033 ENOG4105CPC Aldo Keto reductase M479_2039 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) M479_204 ENOG4105FDR Membrane M479_2040 ENOG41060NJ transcriptional regulator M479_2041 ENOG4105F27 Major Facilitator M479_2042 ENOG4105RQF LysR family Transcriptional regulator M479_2043 ENOG4105EJC lysr family transcriptional regulator M479_2045 ENOG4105C8Q Methyl-accepting chemotaxis M479_206 ENOG4105DVT helicase M479_2060 ENOG4105D7Q type ii secretion system M479_2062 ENOG4107QHF type ii secretion system protein e M479_2066 ENOG4107B2H carbonic anhydrase M479_207 ENOG4105CH6 catalase M479_2074 ENOG4105CBG Sulfatase M479_2075 ENOG4105E98 transcriptional regulator DeoR family M479_2076 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of M479_2077 ENOG4105E70 isomerase M479_2078 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB M479_2079 ENOG4105ETZ PTS System M479_208 ENOG4108UII YfaZ family M479_2080 ENOG4105F3R pts system mannose fructose sorbose family iid M479_2081 ENOG4108YTN IIa component M479_2082 ENOG4105CE4 GlcNAc 6-P deacetylase M479_2083 ENOG4105CHR reductase M479_2085 ENOG4105C4X radical SAM domain protein M479_2086 ENOG4105ENH Sulfatase M479_2088 ENOG4105D2N Aldolase M479_209 ENOG4105E0U tyrosine-specific transport protein M479_2091 ENOG4105ETE Transcriptional regulator (LacI family M479_2092 ENOG4105DPW Major facilitator superfamily MFS_1 M479_2094 ENOG4105ETE Transcriptional regulator (LacI family M479_2096 ENOG4105CI1 PTS System M479_2097 ENOG4105C4C beta-galactosidase M479_2098 ENOG4105C4C beta-galactosidase M479_2100 ENOG4105EG2 ABC transporter, permease M479_2102 ENOG4107FKK extracellular solute-binding protein family 1 M479_2105 ENOG4105CNN ABC, transporter M479_2106 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M479_2108 ENOG4108UY0 (LipO)protein M479_2109 ENOG4105NTW Transcriptional regulator M479_212 ENOG4105XPH Ferredoxin M479_2126 ENOG4105WJ3 XRE family Transcriptional regulator M479_2127 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation M479_213 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M479_2131 ENOG4105DFP Integrase M479_2135 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) M479_2136 ENOG4105T95 Thiol disulfide interChange protein M479_2137 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) M479_2138 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) M479_2139 ENOG4105CT7 inner membrane cred family protein M479_214 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M479_2140 ENOG4105EB3 Histidine kinase M479_2141 ENOG4105E3W Two component transcriptional regulator (Winged helix family M479_2142 ENOG4105Y75 tpr repeat protein M479_2145 ENOG4108UT2 hemolysin iii M479_2153 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family M479_2154 ENOG4105D0A hydroxylase M479_2155 ENOG4107RAQ aminopeptidase M479_2158 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase M479_2159 ENOG4108RS6 transposase M479_216 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M479_2160 ENOG4108JQ1 Dehydrogenase M479_2161 ENOG4105E66 phosphoriboisomerase A M479_2163 ENOG4105MPN Membrane M479_2165 ENOG4105D64 Mechanosensitive ion channel M479_2166 ENOG4105D2N Aldolase M479_217 ENOG4105BZU Histidine kinase M479_2170 ENOG4105CV1 Transketolase (EC 2.2.1.1) M479_2171 ENOG4108K0D peptidase, M48 M479_2173 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) M479_2177 ENOG4105RWS endonuclease I M479_2178 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) M479_2179 ENOG4105D7Z glutathione synthase M479_218 ENOG41068CG regulatoR M479_2182 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) M479_2184 ENOG4105CZX twitching motility protein M479_2185 ENOG4105DFA alanine racemase domain protein M479_2186 ENOG4105II7 pyrroline-5-carboxylate reductase M479_2187 ENOG4108VIA integral membrane protein M479_2189 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) M479_219 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC M479_2190 ENOG4105CSA Coproporphyrinogen iii oxidase M479_2191 ENOG4105EUK rtx toxin RtxA M479_2192 ENOG4105K33 Periplasmic Protein M479_2193 ENOG4105K33 Periplasmic Protein M479_2194 ENOG4105CSV Glutaminase M479_2195 ENOG41090ED Protein with unknown function (DUF469) M479_2197 ENOG4105CEN a g-specific adenine glycosylase M479_220 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC M479_2202 ENOG4105CNN ABC, transporter M479_2203 ENOG4105C2J ABC transporter M479_2204 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M479_2205 ENOG4105CXN decarboxylase M479_221 ENOG4106UW1 Major Facilitator superfamily M479_2214 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M479_2216 ENOG4105CDV Ompa motb domain protein M479_222 ENOG4106UW1 Major Facilitator superfamily M479_2235 ENOG4105DUU IucA IucC family protein M479_2236 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) M479_2238 ENOG4105CT4 transporter M479_2239 ENOG4105DQ6 Transposase M479_224 ENOG4105FCK Membrane M479_2241 ENOG4108XTF Outer Membrane Lipoprotein M479_2246 ENOG4107RD7 Flagellar Motor Protein, MotA M479_2252 ENOG410804A Flagellar hook-associated 2 domain-containing protein M479_2257 ENOG4108M3R transcriptional activator CadC M479_2261 ENOG4105E1Q flagellar hook-associated protein M479_2263 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) M479_2264 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) M479_2265 ENOG4105CGA flagellar basal-body rod protein FlgG M479_2266 ENOG4108KPB Flagellar basal-body rod protein FlgF M479_2267 ENOG4105BZE flagellar hook protein, FlgE M479_2268 ENOG4105W00 Flagellar hook capping protein M479_2269 ENOG4108ZC9 flagellar basal-body rod protein flgc M479_227 ENOG4107R6D beta-lactam binding protein AmpH M479_2270 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) M479_2271 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA M479_2275 ENOG4108JIR Flagellum-specific ATP synthase M479_2278 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) M479_228 ENOG4105CT4 transporter M479_2280 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family M479_2282 ENOG4105DD5 Flagellar motor switch protein M479_2283 ENOG4105CN7 Flagellar biosynthetic protein FliP M479_2284 ENOG4105VS8 Flagellar biosynthetic protein fliq M479_2285 ENOG4105D19 Role in flagellar biosynthesis (By similarity) M479_2286 ENOG4105D00 flagellar biosynthetic protein flhB M479_2290 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein M479_2293 ENOG4106P2F Pfam:Pili_assembly_C M479_2294 ENOG4106PG1 outer membrane usher protein M479_230 ENOG4105C8Q Methyl-accepting chemotaxis M479_2309 ENOG4108ZZF transport protein (ExbD) M479_2311 ENOG4105CWK Biopolymer transport protein, ExbB M479_2312 ENOG4105C28 cystathionine M479_2313 ENOG4108K81 inner membrane protein YghB M479_2314 ENOG4105CF7 AraC family transcriptional regulator M479_2315 ENOG4108I6A alcohol dehydrogenase M479_2316 ENOG4105CV8 reductase M479_2319 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) M479_2320 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase M479_2321 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M479_2322 ENOG4105NF4 modulator of drug activity M479_2323 ENOG4105CR8 Transcriptional regulator M479_2324 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M479_2325 ENOG4105IPS esterase M479_2326 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) M479_2327 ENOG4108SX3 cytoplasmic protein M479_2328 ENOG41087AY ADP-Ribose pyrophosphatase M479_2329 ENOG4105DFG type I secretion outer membrane protein M479_233 ENOG4105Y50 Virulence Protein M479_2332 ENOG4106032 Glutathionylspermidine synthase M479_2333 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b M479_2336 ENOG4105W0Z cytoplasmic protein M479_2337 ENOG4105DVH amino acid M479_2340 ENOG4105I7R Adenylate cyclase M479_2341 ENOG4106MWK domain protein M479_2344 ENOG4107ZVW dihydroneopterin aldolase M479_2347 ENOG4105VCC 30S ribosomal protein S21 M479_2348 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) M479_2349 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M479_235 ENOG4105HRS Antitermination protein M479_236 ENOG4105G63 Type III effector Hrp-dependent M479_2366 ENOG4105KME endoribonuclease L-psp M479_2370 ENOG4105CHM Aminotransferase M479_2373 ENOG4105J12 Multidrug resistance protein mdtN M479_2374 ENOG4108MI0 Resistance protein M479_2376 ENOG4107QK4 glycoside hydrolase, family 3 domain protein M479_2378 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component M479_238 ENOG4105MVE transcriptional regulator M479_2380 ENOG4108IJG ABC transporter substrate-binding protein M479_2381 ENOG4107KJX Transcriptional regulator M479_2382 ENOG4107T40 Inherit from COG: Glycosyltransferase 36 M479_2387 ENOG4105CKT filamentous hemagglutinin M479_2389 ENOG4105CKT filamentous hemagglutinin M479_239 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) M479_2391 ENOG4105CKT filamentous hemagglutinin M479_2392 ENOG4105D5K Hemolysin activator protein M479_2393 ENOG4108M24 von Willebrand factor, type A M479_2396 ENOG4108M24 von Willebrand factor, type A M479_2399 ENOG4108YK4 Acid-resistance membrane protein M479_2400 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase M479_2403 ENOG4108VKG metal-dependent hydrolase M479_2404 ENOG4105EE0 oxidoreductase M479_2407 ENOG4108RS6 transposase M479_2408 ENOG4105P66 Membrane M479_2409 ENOG4105CTX dehydratase M479_2410 ENOG4107QZW Altronate oxidoreductase M479_2412 ENOG4105DPW Major facilitator superfamily MFS_1 M479_2413 ENOG4105DPW Major facilitator superfamily MFS_1 M479_2416 ENOG4106W5V Membrane M479_2419 ENOG4105NE1 Conserved Protein M479_2420 ENOG41090KG Inner membrane protein YqjE M479_2422 ENOG4108VBZ doxx family M479_2423 ENOG4105CHF Glutathione S-transferase M479_2424 ENOG4105CWB LysR family transcriptional Regulator M479_2425 ENOG4108CNN domain protein M479_2426 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) M479_243 ENOG4105TKZ Tail Sheath M479_2430 ENOG4105W4M Transport-associated protein M479_2432 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain M479_2433 ENOG4105BZU Histidine kinase M479_2434 ENOG4105N5T Radical SAM Protein M479_2435 ENOG4105CBC glutamate synthase M479_2436 ENOG4105BZ8 glutamate synthase M479_2438 ENOG4105KB2 stringent starvation protein b M479_2439 ENOG4107MKT Stringent starvation protein a M479_2442 ENOG4105D6Z AFG1 family ATPase M479_2443 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III M479_2444 ENOG4105C0H protease M479_2445 ENOG4108RS6 transposase M479_2446 ENOG4105C0H protease M479_2448 ENOG4105VFK BolA family M479_2449 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane M479_2450 ENOG4105E3I toluene tolerance M479_2451 ENOG4107PE3 Mammalian cell entry related domain protein M479_2452 ENOG4105CY3 ABC transporter, permease M479_2453 ENOG4105DHJ ABC, transporter M479_2454 ENOG4105FEU K -dependent Na -Ca exchanger M479_2455 ENOG4105C2X Arabinose 5-phosphate isomerase M479_2456 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase M479_2457 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) M479_2458 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA M479_2459 ENOG4108IUZ ABC transporter M479_2460 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M479_2461 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA M479_2462 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN M479_2464 ENOG41080Z8 PHOSPHOCARRIER protein M479_2467 ENOG4105KME endoribonuclease L-psp M479_2469 ENOG4105D4X repressor M479_2470 ENOG4105C5Y PTS System M479_2471 ENOG4105CG3 alpha amylase, catalytic region M479_2472 ENOG4105NXH GreA GreB family elongation factor M479_2473 ENOG4108XVM Cytochrome b(562) M479_2475 ENOG4105CMS peptidase U62, modulator of DNA gyrase M479_2477 ENOG4105UNR (Barnase) inhibitor M479_2480 ENOG4105C26 Dehydrogenase M479_2484 ENOG4105CR8 Transcriptional regulator M479_2495 ENOG4105D1U peptidase U62 modulator of DNA gyrase M479_2497 ENOG4105QD6 exported protein M479_2498 ENOG4105C03 ribonuclease M479_25 ENOG4108N8T regulatoR M479_2500 ENOG4105VQ7 Rod shape-determining protein MreD M479_2501 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) M479_2502 ENOG4105DFF Rod shape-determining protein mreb M479_2503 ENOG41062P1 Diguanylate cyclase phosphodiesterase M479_2504 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family M479_2505 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) M479_2508 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein M479_2509 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase M479_2511 ENOG4105RG0 Membrane M479_2512 ENOG4108IA2 Sodium pantothenate symporter M479_2514 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) M479_2515 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) M479_2518 ENOG4105CSH Transporter M479_2519 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase M479_252 ENOG4108T86 baseplate J family protein M479_2522 ENOG4108XTF Outer Membrane Lipoprotein M479_2523 ENOG4105VEQ Cold shock protein M479_2524 ENOG4105VEQ Cold shock protein M479_2525 ENOG4108RS6 transposase M479_2528 ENOG4105CYM Glutathione S-transferase M479_2529 ENOG4105C2X Arabinose 5-phosphate isomerase M479_2530 ENOG4105EF1 ribulokinase M479_2532 ENOG4105CNN ABC, transporter M479_2533 ENOG4105C2J ABC transporter M479_2535 ENOG4105D1S lipid A biosynthesis M479_2537 ENOG4105EEQ Na H antiporter M479_2538 ENOG4105C7N Xanthine uracil vitamin C permease M479_2541 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component M479_2543 ENOG4105GVF (ABC) transporter M479_2545 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) M479_2546 ENOG4108RVA ribokinase M479_2547 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) M479_2548 ENOG4105W4W Transcriptional regulator M479_2549 ENOG4107TYG Oxidoreductase domain-containing protein M479_2552 ENOG4105CNA YD repeat protein M479_2554 ENOG4105CS6 Rhs element vgr protein M479_256 ENOG4108Q3X Transcriptional regulator M479_2560 ENOG4105CNA YD repeat protein M479_2563 ENOG4105CS6 Rhs element vgr protein M479_2570 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M479_2579 ENOG4105DQ6 Transposase M479_258 ENOG4105CS2 ec 3.2.1.21 M479_2583 ENOG4108WC9 type VI secretion system effector, hcp1 family M479_2585 ENOG4107W52 maltose operon periplasmic protein M479_2589 ENOG4107FKK extracellular solute-binding protein family 1 M479_2590 ENOG4105D56 permease protein M479_2591 ENOG4105EG2 ABC transporter, permease M479_2594 ENOG4105CFH Aspartokinase M479_2598 ENOG4105C3R Methionine synthase M479_2599 ENOG41069M3 Transcriptional regulator M479_2601 ENOG4108I9X Isocitrate lyase M479_2602 ENOG4107QP3 malate synthase g M479_2613 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M479_2614 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase M479_2615 ENOG4105C34 Pseudouridine synthase M479_2616 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane M479_2617 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA M479_2619 ENOG4105EHE chorismate mutase- prephenate dehydrogenase M479_262 ENOG4105GMB type VI secretion system effector, hcp1 family M479_2623 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) M479_2624 ENOG4108NEV two component transcriptional regulator, LytTR family M479_2625 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter M479_2626 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter M479_2627 ENOG4108NE3 Salt-induced outer membrane protein M479_2632 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY M479_2633 ENOG4106KVJ cytochrome C assembly protein M479_2634 ENOG4108JU6 CBS domain protein M479_2636 ENOG4105D9M gamma-glutamylcysteine synthetase M479_2637 ENOG4105W39 Membrane M479_2638 ENOG4107VXZ Hydrolase M479_2642 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) M479_2643 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) M479_265 ENOG4105E68 Sulfatase M479_2650 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) M479_2651 ENOG4108IUS Transketolase M479_2652 ENOG4108HHA Transketolase M479_2653 ENOG4105CNN ABC, transporter M479_2654 ENOG4105C2J ABC transporter M479_2658 ENOG4108XVM Cytochrome b(562) M479_2659 ENOG4105CPW cytochrome b561 M479_266 ENOG4105PAN UPF0352 protein M479_2660 ENOG4108NEM leader-binding protein dmsD M479_2661 ENOG4107KGK dmso reductase anchor subunit M479_2662 ENOG4105QAX Iron-sulfur M479_2663 ENOG4107QY8 reductase M479_2664 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase M479_2665 ENOG4105E98 transcriptional regulator DeoR family M479_2667 ENOG4105C2J ABC transporter M479_2668 ENOG4105CNN ABC, transporter M479_2669 ENOG4105F5R ABC transporter M479_2670 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase M479_2671 ENOG4105CMG Carbohydrate kinase M479_2672 ENOG4107GFK fumarate M479_2674 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) M479_2676 ENOG4105D05 Receptor M479_2678 ENOG4105CA0 peroxidase M479_2679 ENOG4105E89 ABC transporter M479_268 ENOG4108RS6 transposase M479_2684 ENOG4105DKT Transcriptional regulator M479_2686 ENOG4105CMT Dihydroxyacetone kinase M479_2687 ENOG4105CHR reductase M479_2688 ENOG4105CPQ Dehydrogenase M479_2689 ENOG4108YZG isomerase M479_2690 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) M479_2691 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M479_2692 ENOG4108K5P (LipO)protein M479_2697 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) M479_2699 ENOG4105N0Z inner membrane protein ygbE M479_27 ENOG4105VEQ Cold shock protein M479_270 ENOG4105CFI type iii restriction protein res subunit M479_2700 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) M479_271 ENOG4105I08 Pseudouridine synthase M479_2711 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase M479_2712 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) M479_2716 ENOG4105DXN mazG family M479_2717 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) M479_2718 ENOG4105BZU Histidine kinase M479_2719 ENOG4105C0H protease M479_272 ENOG4105C2C drug resistance transporter, Bcr CflA M479_2721 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) M479_2723 ENOG4105EN6 Membrane M479_2727 ENOG4105S6R Iron-hydroxamate transporter permease subunit M479_2728 ENOG4105J76 Periplasmic binding protein M479_2729 ENOG4105E0A ABC, transporter M479_273 ENOG4105HG6 M479_2730 ENOG4105BZ4 penicillin-binding protein M479_2731 ENOG4105CQ7 ATP-dependent helicase M479_2732 ENOG4107XID 2'-5' rna ligase M479_2734 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters M479_2735 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) M479_2736 ENOG4105DJ0 Poly(A) Polymerase M479_2737 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase M479_274 ENOG4108JQ5 ABC transporter M479_2741 ENOG4107BJW polysaccharide deacetylase M479_2743 ENOG4105E3A (ABC) transporter M479_2744 ENOG4105DA5 (ABC) transporter M479_2745 ENOG41077A9 carbonic anhydrase M479_2746 ENOG4108UGV hypoxanthine phosphoribosyltransferase M479_2747 ENOG4105E3B Multicopper oxidase M479_2748 ENOG4108ZRK uncharacterized protein yacC M479_275 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component M479_2751 ENOG4105RPH Inner membrane protein YddG M479_2753 ENOG4107QIJ Aconitate hydratase 2 M479_2754 ENOG4108RS6 transposase M479_2755 ENOG4107QN2 dihydrolipoyl dehydrogenase M479_2756 ENOG4107QSN dihydrolipoamide acetyltransferase M479_2757 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) M479_2758 ENOG41073TP transcriptional regulator M479_2759 ENOG4105C85 amino acid M479_276 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component M479_2760 ENOG4106A72 regulatory protein AmpE M479_2761 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase M479_2762 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase M479_2763 ENOG4108ZUW Major pilin subunit M479_2764 ENOG4107QHF type ii secretion system protein e M479_2765 ENOG4105D7Q type ii secretion system M479_2767 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) M479_277 ENOG4105E43 Extracellular solute-binding protein, family 5 M479_2774 ENOG4105M6F mutator MutT protein M479_2779 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) M479_278 ENOG4105CXC rtn protein M479_2780 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) M479_2781 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) M479_2785 ENOG4105CNI cell division protein FtsW M479_2788 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) M479_2789 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) M479_2790 ENOG4105CJN penicillin-binding protein M479_2791 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) M479_2794 ENOG4108RNS Exports L-alanine (By similarity) M479_2796 ENOG4107B7Y DNA-binding transcriptional regulator FruR M479_2797 ENOG4108RS6 transposase M479_2798 ENOG4108ZP8 Acetolactate synthase small subunit M479_2799 ENOG4105C7K acetolactate synthase M479_28 ENOG4107Z6W Protein CrcB homolog M479_280 ENOG4107TT5 NLP P60 protein M479_2801 ENOG4108IQE Amp-dependent synthetase and ligase M479_2802 ENOG41064T2 transcriptional regulator, lysR family M479_2805 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) M479_2808 ENOG4105S8Q sugar efflux transporter M479_281 ENOG41076MN Phosphoesterase, PA-phosphatase related M479_2811 ENOG4105DP9 ABC transporter M479_2812 ENOG4106SMU thiamine transporter membrane protein M479_2814 ENOG4108KF1 Membrane M479_2815 ENOG4105CQ2 DNA polymerase M479_282 ENOG4105CKI cobalamin synthesis protein M479_2826 ENOG4105CS6 Rhs element vgr protein M479_2827 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M479_2836 ENOG4105D3G Pseudouridine synthase M479_2837 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) M479_2839 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) M479_284 ENOG4107YCY Transcriptional regulator M479_2840 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) M479_2845 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) M479_2847 ENOG4105DWK Membrane M479_2848 ENOG4105N14 lysine exporter protein LysE YggA M479_2849 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain M479_285 ENOG4105DEI Mannitol dehydrogenase M479_2850 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain M479_2853 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase M479_2856 ENOG4105DTN riboflavin biosynthesis protein ribF M479_2858 ENOG41063Z6 transcriptional regulator, lysR family M479_286 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) M479_2862 ENOG4106HK8 GPR1 FUN34 yaaH family protein M479_2865 ENOG4108RIR Molybdenum cofactor biosynthesis protein M479_2873 ENOG41065U4 response regulator M479_2874 ENOG4108RH0 Crea protein M479_2877 ENOG4105UEI Transcriptional Regulator AraC Family M479_2878 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) M479_2880 ENOG4107SC1 transglycosylase M479_2883 ENOG4108KHX Diguanylate cyclase M479_2884 ENOG41090EK ompa motb domain protein M479_2885 ENOG4105C5H ABC transporter M479_2888 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase M479_2889 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) M479_289 ENOG4105KRS Proteinase inhibitor M479_2890 ENOG4105EAC phosphoserine phosphatase M479_2891 ENOG41062Z9 Membrane M479_2895 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) M479_2896 ENOG4105D9N nucleoside M479_2897 ENOG4105D9N nucleoside M479_2898 ENOG4105EYA deoxyribonuclease M479_2899 ENOG4108NRW Phospholipase, patatin family M479_29 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) M479_290 ENOG4105CHR reductase M479_2901 ENOG4105K3G Periplasmic Protein M479_2903 ENOG4105KEG ribosomal-protein-alanine acetyltransferase M479_2904 ENOG4108WPU DNA polymerase III subunit psi M479_2907 ENOG4105YBH Protein of unknown function (DUF1435) M479_2908 ENOG4105BZU Histidine kinase M479_2911 ENOG4105BZS acriflavin resistance protein M479_2912 ENOG410624X efflux transporter, rnd family, mfp subunit M479_2915 ENOG4105DKP glycosyl transferase, family 9 M479_2917 ENOG4105DKT Transcriptional regulator M479_2924 ENOG4105RI1 glycoprotein receptor M479_2925 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) M479_2926 ENOG4105DM4 PTS System M479_2927 ENOG4108YRF PTS System M479_2928 ENOG4106R3P AraC family transcriptional regulator M479_2929 ENOG4108XCZ PTS System M479_293 ENOG4105C26 Dehydrogenase M479_2931 ENOG4108M3P Membrane M479_2943 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 M479_2946 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) M479_295 ENOG4105E66 phosphoriboisomerase A M479_2950 ENOG4108K5H permease YjgP YjgQ family protein M479_2951 ENOG4108M8S permease YjgP YjgQ family protein M479_2953 ENOG4105MYG DNA polymerase iii, chi subunit M479_2954 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) M479_2955 ENOG4108MJ3 acetyltransferase M479_2956 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) M479_2957 ENOG4105DBV ornithine carbamoyltransferase M479_2958 ENOG4105XEP YhcH YjgK YiaL family protein M479_2961 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M479_2962 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M479_2963 ENOG4105C3U ABC transporter M479_2964 ENOG4108JQ7 (ABC) transporter M479_2965 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase M479_2966 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) M479_2968 ENOG4107RJJ Transcriptional regulator M479_2969 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG M479_297 ENOG4105C2J ABC transporter M479_2970 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH M479_2971 ENOG4105EKV Phosphonate metabolism protein M479_2972 ENOG4105FT8 Phosphonate metabolism M479_2973 ENOG4105ENV phosphonate C-P lyase system protein PhnK M479_2974 ENOG4105HRV phosphonate c-p lyase system protein phnl M479_2975 ENOG4105FD8 phosphonate metabolism protein PhnM M479_2976 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) M479_2977 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein M479_2978 ENOG4105K4T epimerase M479_298 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane M479_2982 ENOG4105DRS transport system, permease M479_2983 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component M479_2988 ENOG4108YYD acetyltransferase M479_2989 ENOG4105XPQ lipid carrier protein M479_2990 ENOG4105CFP Peptidase U32 M479_2991 ENOG4106RZ4 Peptidase U32 M479_2992 ENOG4105ENJ RND efflux system, outer membrane lipoprotein M479_2993 ENOG4105BZS acriflavin resistance protein M479_2996 ENOG4105DEN Luciferase family M479_2999 ENOG4105C1J atp-dependent rna helicase M479_3 ENOG4105DN3 alpha-2-macroglobulin domain protein M479_300 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein M479_3003 ENOG4105DQ6 Transposase M479_3006 ENOG4105C6V Glycerol-3-phosphate dehydrogenase M479_3007 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) M479_301 ENOG4105DE4 1-phosphofructokinase M479_3012 ENOG4108HRK Histidine kinase M479_3018 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) M479_3019 ENOG41076UM multiple antibiotic resistance (MarC)-related protein M479_302 ENOG4105DM4 PTS System M479_3023 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family M479_3024 ENOG4105C6Z Gluconate M479_3025 ENOG4105DIQ Transcriptional regulator M479_3026 ENOG4105DIQ Transcriptional regulator M479_3027 ENOG4105C2I pirin domain protein M479_3029 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M479_303 ENOG4108SGD regulatory protein M479_3031 ENOG4105D2N Aldolase M479_3033 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M479_3034 ENOG4105CNN ABC, transporter M479_3037 ENOG4105CBX hi0933 family M479_3038 ENOG4105CJ3 phosphate transporter M479_3041 ENOG4108M6U Universal stress protein A M479_3045 ENOG4105DGW oligopeptidase A M479_3046 ENOG4105D6S protein involved in catabolism of external DNA M479_3047 ENOG4105DC8 reductase M479_3048 ENOG4107VHA regulatoR M479_3049 ENOG4107QQ0 gntp family M479_3050 ENOG4105BZW Glycerate kinase M479_3055 ENOG4107H3J ribonuclease M479_3056 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) M479_3057 ENOG41066T0 asmA family M479_3058 ENOG4105CMB EAL domain-containing protein M479_3059 ENOG4105VSH 4-oxalocrotonate tautomerase M479_306 ENOG4108UIF Chaperone M479_3060 ENOG4107SS6 2-dehydro-3-deoxygluconokinase M479_3061 ENOG4105CS0 peptidase M479_3066 ENOG4108PU9 oligogalacturonate-specific porin M479_3067 ENOG4105BZU Histidine kinase M479_3068 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) M479_3069 ENOG4108JQ7 (ABC) transporter M479_307 ENOG4108D1K outer membrane usher protein M479_3070 ENOG4105C3U ABC transporter M479_3071 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M479_3072 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M479_3073 ENOG4105DEF Extracellular solute-binding protein, family 5 M479_3075 ENOG4105D5K Hemolysin activator protein M479_3079 ENOG4105CXY transporter M479_3080 ENOG4105BZU Histidine kinase M479_3081 ENOG4108KX4 response regulator M479_3082 ENOG4105DIJ Phosphoethanolamine transferase M479_3086 ENOG4105WSB biofilm stress and motility protein A M479_3087 ENOG4105CSU acyl-Coa dehydrogenase M479_3088 ENOG4105C2N RNA methyltransferase TrmH family group 3 M479_3089 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) M479_309 ENOG4105HMI Membrane M479_3093 ENOG4105EPW hflc protein M479_3094 ENOG4107QJR hflk protein M479_3095 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) M479_3099 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M479_310 ENOG4105DUM transcriptional regulator, lysR family M479_3100 ENOG4105K8N protein family UPF0079, ATPase M479_3101 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) M479_3102 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) M479_3105 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) M479_3108 ENOG4105EGS Mechanosensitive ion channel M479_3113 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) M479_3114 ENOG4105KPY Small multidrug resistance protein M479_3116 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein M479_3117 ENOG4108ZVF (LipO)protein M479_312 ENOG4108IQI permease M479_3122 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter M479_3125 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) M479_3126 ENOG4108RC0 Electron transport protein M479_3127 ENOG4105BZ8 glutamate synthase M479_3128 ENOG4108SIC Transcriptional regulator M479_3143 ENOG4105C0A alcohol dehydrogenase M479_3145 ENOG4108UUM single-stranded DNA-binding protein M479_3146 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) M479_3147 ENOG4105MSB protein, conserved in bacteria M479_3148 ENOG4105CGF Aromatic amino acid aminotransferase M479_3149 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) M479_315 ENOG4105EHG Permease protein M479_3150 ENOG4105CDU Replicative dna helicase M479_3151 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein M479_3152 ENOG4105P4Z Phage shock protein G M479_3153 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) M479_3154 ENOG4105MYN Zinc uptake regulation protein M479_3156 ENOG41080IJ Diacylglycerol kinase M479_3165 ENOG4108S1B Periplasmic chaperone protein M479_317 ENOG4105D05 Receptor M479_3177 ENOG4105DAX Pfam:DUF2983 M479_318 ENOG4108TGY Glutathione S-transferase M479_3181 ENOG4105D4P Coproporphyrinogen iii oxidase M479_3182 ENOG41090JE Utilization Protein M479_3184 ENOG4107F3C Hemin uptake protein M479_3185 ENOG4107ENK receptor M479_3186 ENOG4106QJH hemin transport protein M479_3187 ENOG4107R4I Periplasmic binding protein M479_3188 ENOG4105EHG Permease protein M479_3190 ENOG4105C28 cystathionine M479_3191 ENOG4105C44 Serine transporter M479_3192 ENOG4105EQ2 LysR family Transcriptional regulator M479_3193 ENOG4105KSU Redox protein M479_3194 ENOG41066VF YeeE YedE family protein M479_3195 ENOG4108IUF type iii secretion M479_3196 ENOG4108TN6 type iii secretion M479_3197 ENOG41083GP type iii secretion M479_3198 ENOG4108HHI Type III secretion system protein M479_3199 ENOG41063Q7 Type III secretion system protein M479_3202 ENOG4108JIR Flagellum-specific ATP synthase M479_3214 ENOG4105BZU Histidine kinase M479_3215 ENOG4105WH1 Two component transcriptional regulator luxr family M479_3216 ENOG4105CK2 sodium dicarboxylate symporter M479_3218 ENOG41062QD Membrane M479_322 ENOG4105D01 (LipO)protein M479_3224 ENOG4105CMM transposase M479_3231 ENOG4108Z0R Transferase M479_3234 ENOG4108WI1 Dna topoisomerase M479_3236 ENOG4105C79 DNA protecting protein DprA M479_324 ENOG4108UMI ABC transporter, permease M479_3240 ENOG4105C1A potassium transporter peripheral membrane M479_3242 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system M479_3243 ENOG4105W1Y Transcriptional regulator M479_3246 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) M479_3249 ENOG41067V7 50S ribosomal protein L36 M479_325 ENOG4105DZ1 carboxypeptidase M479_3250 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) M479_3252 ENOG4105VPB 50S ribosomal protein L30 M479_326 ENOG4105C44 Serine transporter M479_3261 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal M479_3263 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) M479_3264 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) M479_3266 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) M479_327 ENOG4107FB0 transcriptional regulator DeoR family M479_3274 ENOG4108RS6 transposase M479_3277 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) M479_328 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) M479_3282 ENOG4105WWK YheO domain protein M479_3283 ENOG4108V1T peptidylprolyl cis-trans isomerase M479_3285 ENOG4108YZY peptidylprolyl cis-trans isomerase M479_3286 ENOG4105VKU nucleicacid-binding protein M479_3289 ENOG4105C5H ABC transporter M479_329 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase M479_3290 ENOG4105K64 Glycosyl transferase, family 2 M479_3293 ENOG4105E2B Taurine dioxygenase M479_3294 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component M479_3296 ENOG4106FTQ Taurine ABC transporter, periplasmic M479_3298 ENOG4105DNZ Alpha Beta Hydrolase M479_33 ENOG4105DZ1 carboxypeptidase M479_3300 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) M479_3302 ENOG4108UKZ OsmC family M479_3304 ENOG410613R integral membrane protein, YccS YhfK family M479_3305 ENOG4105C8Y Acetylornithine aminotransferase M479_3307 ENOG4105D7A ATP-binding protein M479_3308 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) M479_3309 ENOG4105F8D glycoside hydrolase family 4 M479_331 ENOG4105D0C transport protein M479_3310 ENOG41060NJ transcriptional regulator M479_3313 ENOG4105DZC cytosine deaminase M479_3314 ENOG4107QZF nitrite reductase NADPH large subunit M479_3315 ENOG4105WZK nitrite reductase NADPH small subunit M479_3316 ENOG4107V9H nitrite transporter M479_3318 ENOG4105C31 Tryptophanyl-tRNA synthetase M479_3319 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) M479_332 ENOG41090BQ Glutaredoxin M479_3320 ENOG4105DJV ribulose-phosphate 3-epimerase M479_3325 ENOG4105E4G Type IV pilus M479_333 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress M479_3330 ENOG4108JQC penicillin-binding protein 1A M479_3331 ENOG4107RK2 ADP-ribose diphosphatase NudE M479_3333 ENOG4105DQY intracellular growth attenuator M479_3334 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 M479_3335 ENOG4105VEJ Heat shock protein M479_3338 ENOG4105E0F Histidine kinase M479_3339 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M479_334 ENOG4108RMJ sensory transduction regulator M479_3340 ENOG4108RRZ Transcription elongation factor GreB M479_3341 ENOG4105BZM domain protein M479_3342 ENOG4105XFK Ferrous iron transport protein A M479_3343 ENOG4105CE1 Ferrous iron transport protein b M479_3345 ENOG4105RID UPF0379 protein yhcN M479_3347 ENOG4105MJ2 Competence protein M479_3349 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) M479_335 ENOG4107RUE extracellular solute-binding protein family 1 M479_3350 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) M479_3354 ENOG4105E98 transcriptional regulator DeoR family M479_3356 ENOG4105DQ6 Transposase M479_336 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) M479_3362 ENOG4105D13 transposase M479_3363 ENOG4105EM7 Selenocysteine-specific translation elongation factor M479_3366 ENOG4108MG3 formate dehydrogenase M479_3367 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein M479_3368 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) M479_3369 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) M479_337 ENOG4105F38 ABC transporter, permease M479_3371 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) M479_3372 ENOG4105C8Q Methyl-accepting chemotaxis M479_3376 ENOG4108YYI Protein of unknown function (DUF2810) M479_3378 ENOG4105E61 Mannitol repressor protein M479_338 ENOG4105D38 putrescine abc transporter M479_3380 ENOG4105CTS PTS system mannitol-specific M479_3381 ENOG4106JH6 (LipO)protein M479_3385 ENOG4108R3E Dna-3-methyladenine glycosylase i M479_3387 ENOG4108ZG0 Ompa motb domain protein M479_339 ENOG4105RBQ inner membrane protein ybjO M479_3390 ENOG4107T9C Alpha amylase catalytic region M479_3392 ENOG4105JKW Valine--pyruvate aminotransferase M479_3396 ENOG4105R2A (LipO)protein M479_3397 ENOG4105D99 atp gtp-binding protein M479_3398 ENOG4105D99 atp gtp-binding protein M479_3399 ENOG4105C7B Threonine dehydratase M479_34 ENOG4105K6T rare lipoprotein A M479_3402 ENOG4105DQ6 Transposase M479_3403 ENOG410667J hydrolase M479_3404 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M479_3405 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) M479_3406 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) M479_3409 ENOG4105VG0 50S ribosomal protein l34 M479_3412 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins M479_3417 ENOG4105C7N Xanthine uracil vitamin C permease M479_3418 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 M479_3419 ENOG4105DRP amino acid AbC transporter M479_3420 ENOG4105EAD ABC transporter M479_3421 ENOG4106PMH Extracellular solute-binding protein family 3 M479_3425 ENOG4105E2Z phosphate ABC transporter (Permease M479_3426 ENOG4105C8U phosphate abc transporter M479_3427 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) M479_3428 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) M479_3436 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) M479_3438 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation M479_3441 ENOG4105QTB Flavodoxin M479_3442 ENOG4108VVK transcriptional Regulator, AsnC M479_3448 ENOG4108RVA ribokinase M479_3449 ENOG4108RVA ribokinase M479_345 ENOG4105DQ5 transport system permease protein M479_3450 ENOG4105C0R drug resistance transporter emrb qaca subfamily M479_3452 ENOG4107EJG GntR family transcriptional regulator M479_3458 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b M479_346 ENOG4105E0A ABC, transporter M479_3460 ENOG4105PC1 Conserved Protein M479_3461 ENOG4105E27 serine threonine protein kinase M479_3462 ENOG4108Z33 Thiol disulfide Interchange Protein M479_3463 ENOG4105C2M dna polymerase I M479_3466 ENOG4105D4P Coproporphyrinogen iii oxidase M479_3467 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family M479_3468 ENOG4105CUX Signal transduction histidine kinase M479_3469 ENOG4105C5F glutamine synthetase M479_347 ENOG410642S Nicotianamine synthase protein M479_3471 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 M479_3472 ENOG4107S2Z UPF0761 membrane protein M479_3476 ENOG4105SUU thioesterase domain M479_3477 ENOG4105JV1 AsmA family M479_3478 ENOG4105C2W permease M479_3479 ENOG4105D6U Sodium Glutamate Symporter M479_348 ENOG4108MRU Uncharacterized protein conserved in bacteria (DUF2338) M479_3480 ENOG4105CB5 ATP-dependent DNA helicase recG M479_3481 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase M479_3482 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) M479_3485 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) M479_3486 ENOG4105EN6 Membrane M479_3487 ENOG4105DSJ YicC domain protein M479_349 ENOG4108I0N Transporter, RarD family, DMT superfamily protein M479_3492 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase M479_3495 ENOG4105W0E 50S ribosomal protein L33 M479_3499 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase M479_35 ENOG4105CNI cell division protein FtsW M479_350 ENOG4105DMR ABC, transporter M479_3500 ENOG4105D16 lipopolysaccharide heptosyltransferase i M479_3501 ENOG4105XA0 heptosyltransferase ii M479_3503 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) M479_3505 ENOG4105PXI polysaccharide deacetylase M479_3506 ENOG4105PXI polysaccharide deacetylase M479_3507 ENOG41063SB peptidase M479_3509 ENOG4107YZP Rhodanese domain protein M479_351 ENOG4105GBT ABC transporter M479_3510 ENOG4105VW4 glutaredoxin 3 M479_3513 ENOG4105D7W serine acetyltransferase M479_3514 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) M479_3515 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) M479_3516 ENOG4105E0F Histidine kinase M479_3517 ENOG4105E3W Two component transcriptional regulator (Winged helix family M479_3518 ENOG4105FMW periplasmic M479_352 ENOG4106PMH Extracellular solute-binding protein family 3 M479_3523 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein M479_3525 ENOG4107QPK )-transporter M479_3526 ENOG4107QPK )-transporter M479_3527 ENOG4105JSC dimethylmenaquinone methyltransferase M479_3529 ENOG4107F9Y LysR family transcriptional regulator M479_353 ENOG4105E5Z arginine transporter ATP-binding subunit M479_3531 ENOG4105EBK exported protein M479_3532 ENOG4108VTS Membrane M479_3533 ENOG4105DP0 ferredoxin-NADP reductase M479_3534 ENOG4105CBT Fructose-1,6-bisphosphatase M479_3535 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) M479_3536 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) M479_3539 ENOG4108JJA ABC, transporter M479_354 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) M479_3540 ENOG4108MBX Secretion Protein M479_3544 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase M479_3547 ENOG41063M6 Cell Division Protein M479_3548 ENOG4105ETE Transcriptional regulator (LacI family M479_355 ENOG41064MM (LipO)protein M479_3550 ENOG4105C25 Primosomal protein n' M479_3552 ENOG4108Z12 YiaAB two helix domain-containing protein M479_3554 ENOG4105C28 cystathionine M479_3555 ENOG4105CFH Aspartokinase M479_3556 ENOG4105SYT Methylenetetrahydrofolate reductase M479_3557 ENOG4105DQ6 Transposase M479_356 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase M479_3560 ENOG4105MEV Acyl-transferase M479_3561 ENOG4106EAR Fimbrial protein M479_3564 ENOG4108TTM chaperone M479_3566 ENOG4105CMG Carbohydrate kinase M479_3568 ENOG4105DFW ABC transporter M479_357 ENOG4105CGD Nad-dependent epimerase dehydratase M479_3570 ENOG4107RNG ABC transporter M479_3571 ENOG4105T16 Transcriptional regulator (AraC family) M479_3573 ENOG4105DFP Integrase M479_3575 ENOG4105ZTC transcriptional activator, Ogr delta M479_358 ENOG4105C5W Aldolase M479_3580 ENOG4108IPW abc transporter atp-binding protein M479_3582 ENOG4105CM4 permease protein M479_3588 ENOG4105C6T cysteine synthase M479_359 ENOG4105C7K acetolactate synthase M479_3590 ENOG4105C84 Histidine ammonia-lyase M479_3591 ENOG4105C85 amino acid M479_36 ENOG4105CJN penicillin-binding protein M479_360 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) M479_3601 ENOG4105PM1 preprotein translocase subunit SecE M479_3602 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) M479_3610 ENOG4105D41 biosynthesis protein thiH M479_3611 ENOG4105D41 biosynthesis protein thiH M479_3615 ENOG4105D06 uba thif-type nad fad binding protein M479_3617 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) M479_362 ENOG4105DWU Membrane M479_3622 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) M479_3623 ENOG4105R2J Conserved Protein M479_3625 ENOG4108T8B Protein of unknown function (DUF1481) M479_3626 ENOG4105C12 Phosphoribosylglycinamide synthetase M479_363 ENOG4105CPB ATP-dependent endonuclease of the OLD family M479_3636 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator M479_3637 ENOG4105C2J ABC transporter M479_3638 ENOG4107R9N ABC transporter M479_364 ENOG4108MJ5 VirK protein M479_3640 ENOG41062B0 ABC transporter, permease M479_3641 ENOG4108WFC UPF0438 protein yifE M479_3642 ENOG4105C0P Mg chelatase subunit ChlI M479_3644 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit M479_3645 ENOG4105CM2 brancheD-chain amino acid aminotransferase M479_3647 ENOG4105C7B Threonine dehydratase M479_365 ENOG4105DJY efflux transporter, rnd family, mfp subunit M479_3653 ENOG4105EMY transcriptional regulator M479_3660 ENOG4108VEV chaperone M479_3662 ENOG4105CW0 outer membrane usher protein M479_3663 ENOG4105GQR Chaperone M479_3666 ENOG4105KQ5 peptidylprolyl cis-trans isomerase M479_3667 ENOG4105C4R Atp-dependent dna helicase M479_367 ENOG4105VEQ Cold shock protein M479_3670 ENOG4105K63 Thioredoxin M479_3672 ENOG4105ESV Glycosyl transferase, family 4 M479_3673 ENOG4105SFE lipopolysaccharide biosynthesis protein M479_3674 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase M479_3675 ENOG4108IJ1 Dehydrogenase M479_3676 ENOG4105C1B dTDP-glucose 4-6-dehydratase M479_3677 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) M479_3678 ENOG4108WJ1 acetyltransferase M479_3679 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase M479_3680 ENOG4105EGZ biosynthesis protein M479_3684 ENOG4105C85 amino acid M479_369 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M479_3691 ENOG410601J HemY protein M479_3692 ENOG4105ECF c-methyltransferase M479_3693 ENOG41076E6 Uroporphyrinogen-III Synthase M479_3695 ENOG4107T0K Adenylate cyclase M479_3697 ENOG4105S7Z (LipO)protein M479_3699 ENOG4105CT0 Protein of unknown function, DUF484 M479_3700 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) M479_3701 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant M479_3702 ENOG4105C4R Atp-dependent dna helicase M479_3704 ENOG4105EQN UPF0261 protein M479_3706 ENOG4107QUT magnesium and cobalt transport protein CorA M479_3707 ENOG4105FR1 rard protein M479_3708 ENOG4108VUY thioesterase Superfamily protein M479_3709 ENOG4105HDD phospholipase M479_371 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) M479_3710 ENOG4105C9U ATP-dependent DNA helicase RecQ M479_3711 ENOG4105CCF Lysine exporter protein (Lyse ygga) M479_3713 ENOG4108EUD Lysophospholipase M479_3714 ENOG4105DQF Hydrolase M479_3716 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase M479_3717 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A M479_3719 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) M479_3720 ENOG4108W1V Lipoprotein M479_3721 ENOG4105EX9 Membrane M479_3724 ENOG4107FS9 Membrane M479_3727 ENOG4105MG3 Membrane M479_3728 ENOG4106H78 methyltransferase M479_3729 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) M479_3729 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) M479_373 ENOG4108JJ8 (ABC) transporter M479_3730 ENOG4105CAK Cell division ATP-binding protein ftsE M479_3731 ENOG4105CRP Part of the ABC transporter FtsEX involved in M479_3733 ENOG4108RS6 transposase M479_3734 ENOG4105U59 -acetyltransferase M479_3735 ENOG4105CP9 extracellular ligand-binding receptor M479_3736 ENOG4105C32 Amino acid ABC transporter (Permease) M479_3737 ENOG4105CF8 branched-chain amino acid ABC transporter, permease M479_3738 ENOG4105C0Z ABC transporter M479_3739 ENOG4108IV0 ABC, transporter M479_374 ENOG4108JJ9 ABC, transporter M479_375 ENOG4105C3M thioredoxin reductase M479_3751 ENOG4107T6V glycerophosphoryl diester phosphodiesterase M479_3752 ENOG4105RK9 auxin efflux carrier M479_3753 ENOG4105DZ2 Transcriptional regulator M479_3754 ENOG4105EMK carboxylate amino acid amine transporter M479_3756 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) M479_3757 ENOG4108I5U Uridine phosphorylase M479_376 ENOG4105EW9 transcriptional regulator AsnC family M479_3760 ENOG4108KF1 Membrane M479_3761 ENOG4105CGY Dna recombination protein M479_3763 ENOG4105JC1 sterol-binding domain protein M479_3765 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) M479_3767 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) M479_3769 ENOG4105D52 delta-aminolevulinic acid dehydratase M479_377 ENOG4105CNU cell division protein FtsK M479_3770 ENOG4105MDZ Transcriptional activator rfaH M479_3772 ENOG4107QK7 reductase M479_3776 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein M479_3777 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) M479_3778 ENOG4108RR8 protoporphyrinogen oxidase M479_3784 ENOG4105D4A Cell wall formation (By similarity) M479_3785 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase M479_3790 ENOG4108MXZ Esterase M479_3793 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) M479_3795 ENOG4108RS6 transposase M479_3797 ENOG4105FHY Opacity-associated protein A M479_3798 ENOG4108V1T peptidylprolyl cis-trans isomerase M479_38 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) M479_380 ENOG4105D1H recombination factor protein RarA M479_3800 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic M479_3801 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase M479_3802 ENOG4108UUE Transcriptional regulator M479_3803 ENOG41061GZ Protein of unknown function (DUF1107) M479_3804 ENOG4105C37 (CBS) domain M479_3806 ENOG4105CFU surface antigen M479_3807 ENOG4105MA0 exported protein M479_3808 ENOG4108ZHD aig2 family M479_3809 ENOG4105F0N pyrophosphate phospho-hydrolase M479_3811 ENOG4105DFU Cell wall formation (By similarity) M479_3815 ENOG4105HVQ Regulatory factor of maltose metabolism M479_3817 ENOG4105EAH synthase M479_382 ENOG4108ISG Major Facilitator M479_3820 ENOG4105QYV Membrane M479_3824 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase M479_3825 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) M479_3826 ENOG4105HBR Rna-binding protein M479_3828 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) M479_3829 ENOG4105EEI dihydropteroate synthase M479_383 ENOG4105F1A Pyruvate formate-lyase M479_3835 ENOG4105CHV Transcription elongation factor NusA M479_3840 ENOG4105DQ6 Transposase M479_3844 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase M479_3848 ENOG4105X58 receptor M479_385 ENOG4105C6N Formate acetyltransferase M479_3851 ENOG4107QZV Type I secretion membrane fusion protein M479_3852 ENOG4105YHG TonB family M479_3853 ENOG4107QN2 dihydrolipoyl dehydrogenase M479_3854 ENOG4105EHV domain protein M479_3856 ENOG4105C5Q Transcriptional regulator M479_3859 ENOG4108Y73 Membrane M479_386 ENOG4105TMB Formate nitrite transporter M479_3868 ENOG4105T42 (LipO)protein M479_3869 ENOG4105JIM Phosphatidylserine synthase M479_387 ENOG4105DDY UPF0142 protein ycaO M479_3870 ENOG4105CD5 CoA-binding domain protein M479_3871 ENOG4106IUH DTW domain containing protein M479_3872 ENOG4105K63 Thioredoxin M479_3873 ENOG4105EIB trna rrna methyltransferase M479_3874 ENOG4105C0R drug resistance transporter emrb qaca subfamily M479_3875 ENOG4105CW7 secretion protein, HlyD family M479_3876 ENOG4105NTK Transcriptional repressor Mpra M479_3877 ENOG4105ZED uncharacterized protein ygaH M479_3878 ENOG4108UMN azlc family M479_3879 ENOG4105EQ0 Major Facilitator superfamily M479_388 ENOG4105HDK L-asparaginase M479_3886 ENOG4105E5Q amino acid AbC transporter M479_3888 ENOG4105C5R Aminotransferase M479_389 ENOG4105EUR Domain-Containing protein M479_389 ENOG4105EUR Domain-Containing protein M479_3891 ENOG4105C5R Aminotransferase M479_3894 ENOG4105CHM Aminotransferase M479_3902 ENOG4106YJS accessory processing protein M479_3905 ENOG4107QPN acyl-Coa dehydrogenase M479_3907 ENOG4105F7V ErfK ybiS ycfS ynhG family protein M479_3908 ENOG4105E7A Glutamine amidotransferase M479_3909 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) M479_3910 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) M479_3911 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) M479_3915 ENOG4105CJ2 (LipO)protein M479_3919 ENOG4105CIN aminoacyl-histidine dipeptidase M479_3930 ENOG4105F2W methyltransferase M479_3935 ENOG4105DKQ ROK family M479_3936 ENOG4105EYH Exonuclease M479_3937 ENOG4107RH8 nuclease SbcCD subunit D M479_3938 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M479_3939 ENOG4105BZU Histidine kinase M479_394 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) M479_3941 ENOG4105CWM branched-chain amino acid transport system II carrier protein M479_3942 ENOG4105C85 amino acid M479_3943 ENOG4107R28 alpha amylase, catalytic region M479_3944 ENOG4105CHR reductase M479_3947 ENOG4105D3R alkyl hydroperoxide reductase M479_3948 ENOG4108ZYK Acyl carrier protein phosphodiesterase M479_3949 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) M479_3951 ENOG4105VIE preprotein translocase, subunit YajC M479_3952 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) M479_3953 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) M479_3958 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) M479_3961 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) M479_3962 ENOG4108ZAI phosphatidylglycerophosphatase a M479_3965 ENOG4105CTB Polyprenyl synthetase M479_3968 ENOG4107S0N DJ-1 family M479_3969 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) M479_397 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 M479_3971 ENOG4107RDB Major Facilitator M479_3973 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) M479_3974 ENOG4105CCU oxidase (Subunit III) M479_3975 ENOG4105BZ9 Cytochrome C oxidase, subunit I M479_3976 ENOG4105E2S oxidase) subunit II M479_3977 ENOG4108NFH Sugar hydrolase M479_3978 ENOG4105EYM Major Facilitator superfamily M479_3979 ENOG4105IEY (LipO)protein M479_3980 ENOG4105M85 Bola protein M479_3985 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) M479_3986 ENOG4105K70 DNA-binding protein M479_3988 ENOG4108RS6 transposase M479_3989 ENOG4105EIN peptidylprolyl cis-trans isomerase M479_3990 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein M479_3991 ENOG4108TGP Thioesterase superfamily protein M479_3993 ENOG4108NFA extracellular solute-binding protein M479_3995 ENOG4105C6T cysteine synthase M479_3996 ENOG4108XM1 transcriptional regulator AsnC family M479_3997 ENOG4105BZ1 (ABC) transporter M479_3998 ENOG4105BZ1 (ABC) transporter M479_3999 ENOG4108YZA Nitrogen regulatory protein pii M479_40 ENOG4105DJF DNA polymerase III, delta' subunit M479_400 ENOG4105E32 cytoplasmic protein M479_4000 ENOG4105BZU Histidine kinase M479_4001 ENOG4105C29 acyl-CoA thioesterase M479_4002 ENOG4108MNP Glycoprotein polysaccharide metabolism M479_4003 ENOG41080UX Methyltransferase M479_4004 ENOG4105KF5 hemolysin expression-modulating protein M479_4005 ENOG4108UKR Biofilm formation regulator YbaJ M479_4007 ENOG4105YK5 50S ribosomal protein L36 M479_4009 ENOG4105BZS acriflavin resistance protein M479_401 ENOG4105VEQ Cold shock protein M479_4010 ENOG4105C1P efflux transporter, rnd family, mfp subunit M479_4011 ENOG4108IG5 Transcriptional regulator M479_4012 ENOG41090EX DsrE family M479_4013 ENOG4105EGS Mechanosensitive ion channel M479_4015 ENOG4105WD1 Membrane M479_4017 ENOG4107QMP dna polymerase iii subunits gamma and tau M479_402 ENOG4105W49 UPF0434 protein M479_4023 ENOG4108EX3 reductase M479_4024 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase M479_4025 ENOG4105FAW cDP-glucose 4,6-dehydratase M479_4026 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase M479_4027 ENOG4108SMP Nad-dependent epimerase dehydratase M479_4034 ENOG4108TJN glycosyl transferase group 1 M479_4035 ENOG4105C0K Gdp-mannose 4,6-dehydratase M479_4036 ENOG4105C0K Gdp-mannose 4,6-dehydratase M479_4037 ENOG4105C30 Nad-dependent epimerase dehydratase M479_4038 ENOG4105CJT Mannose-1-phosphate guanylyltransferase M479_404 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups M479_4041 ENOG4108QY5 Ferric enterobactin transport protein M479_4042 ENOG4107RE1 Inosine-guanosine kinase M479_4043 ENOG4105CKD glutathione-regulated potassium-efflux system protein M479_4044 ENOG4105EU0 Major facilitator Superfamily M479_4045 ENOG4105EU0 Major facilitator Superfamily M479_4046 ENOG4105CGH 5'-nucleotidase M479_4047 ENOG4105CGH 5'-nucleotidase M479_4048 ENOG4105CGH 5'-nucleotidase M479_405 ENOG4106371 Methyltransferase M479_4051 ENOG4108Z66 YbaK ebsC protein M479_4052 ENOG4105MBR gumn family M479_4053 ENOG4105C59 p-type ATPase M479_4054 ENOG4108Z6Z Transcriptional regulator M479_4055 ENOG4105G5H Membrane M479_4056 ENOG4107QX8 SPFH domain, Band 7 family protein M479_4057 ENOG4107QR8 Thioredoxin M479_4058 ENOG4105E1F short-chain dehydrogenase reductase M479_4059 ENOG4108UJV acyl-CoA thioesterase i M479_406 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) M479_4060 ENOG4108I0Y (ABC) transporter M479_4061 ENOG4105CV6 ABC transporter, permease M479_4062 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit M479_4063 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) M479_4065 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) M479_4068 ENOG4108RS6 transposase M479_4069 ENOG4105WQ3 Rna-binding protein M479_407 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) M479_4076 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase M479_4077 ENOG4108HPI phosphatidate Cytidylyltransferase M479_4079 ENOG4105E8V Alpha Beta Hydrolase Fold protein M479_4080 ENOG41077RS Phosphatase M479_4088 ENOG4105EQ2 LysR family Transcriptional regulator M479_4089 ENOG4107SET aldo keto reductase M479_4092 ENOG4107QK4 glycoside hydrolase, family 3 domain protein M479_4096 ENOG4105EZE Cupin 4 family protein M479_410 ENOG4105DIT ErfK YbiS YcfS YnhG family protein M479_4101 ENOG4108WC9 type VI secretion system effector, hcp1 family M479_4106 ENOG4108X9F tail fiber protein M479_4106 ENOG4108X9F tail fiber protein M479_4107 ENOG4105UZW Tail fiber assembly protein M479_411 ENOG4105EAQ (twin-arginine translocation) pathway signal M479_4110 ENOG4105FEQ ParB domain protein nuclease M479_4114 ENOG41073YN Protein of unknown function (DUF1380) M479_4119 ENOG4106RMF ParB family M479_412 ENOG4105C5X domain protein M479_4128 ENOG4105EQR Transposase IS116 IS110 IS902 M479_413 ENOG4105CGF Aromatic amino acid aminotransferase M479_4130 ENOG4106CQM replication M479_4132 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) M479_4169 ENOG4106PHM regulatory protein M479_417 ENOG4105CD8 aminopeptidase N M479_4170 ENOG4108UIF Chaperone M479_4171 ENOG4108D1K outer membrane usher protein M479_4178 ENOG4106J5W DNA polymerase III (alpha subunit) M479_4184 ENOG4105C2M dna polymerase I M479_4186 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) M479_419 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) M479_4195 ENOG4106JVB Replication Protein M479_4197 ENOG4105D2X ABC transporter substrate-binding protein M479_420 ENOG4105QVC MOSC domain-containing protein M479_4203 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M479_4204 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M479_4206 ENOG4108RS6 transposase M479_4216 ENOG4105CB5 ATP-dependent DNA helicase recG M479_4217 ENOG4105FA0 parb-like partition protein M479_4218 ENOG4105FA0 parb-like partition protein M479_422 ENOG4105C5H ABC transporter M479_423 ENOG4105F1S paraquat-inducible protein a M479_4237 ENOG4108NYK Tape measure protein M479_424 ENOG4105DY2 Paraquat-inducible protein b M479_425 ENOG4108Q2G (LipO)protein M479_4257 ENOG4105CMM transposase M479_426 ENOG4108RS6 transposase M479_4260 ENOG4105CMM transposase M479_4269 ENOG4106CQM replication M479_427 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding M479_4270 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) M479_4279 ENOG4105D13 transposase M479_428 ENOG4106G6Q Transcriptional regulator M479_4281 ENOG4108C33 Resolvase M479_4285 ENOG4105CMM transposase M479_4289 ENOG4105CMM transposase M479_4295 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB M479_4296 ENOG4105EZN Cobyrinic acid ac-diamide synthase M479_43 ENOG4107PAI alpha helical protein M479_430 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB M479_431 ENOG4108Z6B deaminase M479_438 ENOG4107WP9 Histidine kinase M479_439 ENOG4108SKK alpha helix protein M479_44 ENOG4105CDA abc transporter atp-binding protein M479_440 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family M479_441 ENOG4105C4K Nad synthetase M479_442 ENOG4108YZA Nitrogen regulatory protein pii M479_443 ENOG4108M21 M479_446 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) M479_449 ENOG4108MN2 Stationary phase inducible protein CsiE M479_45 ENOG4105DRP amino acid AbC transporter M479_450 ENOG4105D8G Major Facilitator superfamily M479_451 ENOG41065CD Exported protein M479_452 ENOG4105D7X high-affinity nickel-transporter M479_456 ENOG4105C3J Cysteine desulfurase M479_457 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins M479_46 ENOG4105EAD ABC transporter M479_460 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB M479_461 ENOG4108ZIT Ferredoxin, 2FE-2S M479_462 ENOG4105WVQ Fe-S assembly protein IscX M479_464 ENOG4105YYA enhanced serine sensitivity protein SseB M479_466 ENOG4108MGN ATP-binding component of a transport system M479_467 ENOG4108MGN ATP-binding component of a transport system M479_47 ENOG4107RP9 extracellular solute-binding protein, family 3 M479_475 ENOG4105N21 Membrane M479_476 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) M479_479 ENOG4105VPD cellular component movement M479_48 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) M479_481 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) M479_483 ENOG4108RS6 transposase M479_484 ENOG4108WC9 type VI secretion system effector, hcp1 family M479_49 ENOG4108JU5 Magnesium and cobalt efflux protein M479_493 ENOG4105DWF phosphomethylpyrimidine kinase M479_495 ENOG4108ZGU inhibitor of vertebrate lysozyme M479_497 ENOG4105CFP Peptidase U32 M479_498 ENOG4105KWI UPF0339 protein M479_499 ENOG4105E3W Two component transcriptional regulator (Winged helix family M479_500 ENOG4105EB3 Histidine kinase M479_506 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) M479_508 ENOG4108JPW Aminotransferase M479_51 ENOG4105C9A Phoh family M479_510 ENOG4105F38 ABC transporter, permease M479_511 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component M479_512 ENOG4105R8A Heat shock protein M479_513 ENOG4105CJW magnesium transporter M479_514 ENOG4105C9X ppx gppa phosphatase M479_515 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) M479_516 ENOG4105C8U phosphate abc transporter M479_517 ENOG4105E2Z phosphate ABC transporter (Permease M479_519 ENOG4108C80 FliB family M479_520 ENOG4108C80 FliB family M479_521 ENOG4108MK9 spermidine N(1)-acetyltransferase M479_522 ENOG4108V3E phosphoribosylglycinamide formyltransferase M479_525 ENOG4108RS6 transposase M479_527 ENOG4105K89 arsenate reductase M479_528 ENOG4105ERG peptidase m48, ste24p M479_529 ENOG4105C02 permease M479_53 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family M479_532 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen M479_533 ENOG4105RH4 Glycine cleavage system transcriptional repressor M479_535 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) M479_536 ENOG4108RS6 transposase M479_538 ENOG4105CGZ zinc metallopeptidase M479_544 ENOG4105KUZ arsenate reductase M479_546 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC M479_547 ENOG4107Z33 ABC transporter, permease M479_548 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) M479_549 ENOG4105ENH Sulfatase M479_550 ENOG4105C4X radical SAM domain protein M479_551 ENOG4105S2T inner membrane protein YbcI M479_553 ENOG4105BZS acriflavin resistance protein M479_555 ENOG4105WH1 Two component transcriptional regulator luxr family M479_556 ENOG4108ZNS ferredoxin-type protein NapF M479_557 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase M479_559 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) M479_560 ENOG4105CUW cytochrome C-TYPE protein M479_562 ENOG4105C6K Malic enzyme M479_569 ENOG4105H4F exported protein M479_571 ENOG4105E7K (LipO)protein M479_572 ENOG4105EZR dyp-type peroxidase family protein M479_577 ENOG4108R66 Conserved Protein M479_578 ENOG4105QEK Transcriptional regulator M479_580 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein M479_581 ENOG4108I5D sulfate abc transporter M479_582 ENOG4105ECW sulfate abc transporter M479_583 ENOG4108IJ6 ABC transporter M479_584 ENOG4105C6T cysteine synthase M479_586 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M479_587 ENOG41062D9 Histidine kinase M479_589 ENOG4105C87 Aminotransferase class I and II M479_591 ENOG4107RAQ aminopeptidase M479_593 ENOG4105E1V na solute symporter M479_596 ENOG4105DJY efflux transporter, rnd family, mfp subunit M479_597 ENOG4105E3W Two component transcriptional regulator (Winged helix family M479_598 ENOG4105E0F Histidine kinase M479_60 ENOG4105CAQ asparagine synthetase M479_601 ENOG4105C5Y PTS System M479_603 ENOG4105KZ7 phosphocarrier protein hpr M479_604 ENOG4105C6T cysteine synthase M479_605 ENOG4105EXN Sulfate transport protein CysZ M479_608 ENOG4105VRT cytoplasmic protein M479_61 ENOG4105D4U had-superfamily hydrolase, subfamily iia M479_611 ENOG4108RS6 transposase M479_618 ENOG4105D9N nucleoside M479_62 ENOG4105E2R ROK family M479_621 ENOG4105CPC Aldo Keto reductase M479_622 ENOG4105C5Q Transcriptional regulator M479_625 ENOG41072TH Protein of unknown function (DUF1479) M479_626 ENOG4105CHM Aminotransferase M479_627 ENOG4108VKM cytochrome b561 M479_629 ENOG4106B0W Curli production assembly transport component CsgG M479_63 ENOG4105CE4 GlcNAc 6-P deacetylase M479_631 ENOG4107Y60 (LipO)protein M479_633 ENOG4108NEM leader-binding protein dmsD M479_634 ENOG4107KGK dmso reductase anchor subunit M479_635 ENOG4105QAX Iron-sulfur M479_636 ENOG4107QY8 reductase M479_638 ENOG4108WC9 type VI secretion system effector, hcp1 family M479_643 ENOG4105CVE Lytic murein transglycosylase M479_65 ENOG4105CI1 PTS System M479_653 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M479_655 ENOG4105GQR Chaperone M479_656 ENOG4105CW0 outer membrane usher protein M479_658 ENOG4105CW0 outer membrane usher protein M479_671 ENOG4105CS6 Rhs element vgr protein M479_677 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA M479_679 ENOG4108V0P LemA family M479_683 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) M479_684 ENOG41060IM Heme exporter protein M479_685 ENOG4105X3C heme exporter protein M479_687 ENOG4105DA4 cytochrome c-type biogenesis protein M479_688 ENOG4107QX9 Thiol disulfide interChange protein M479_689 ENOG4105KWW Biogenesis protein M479_690 ENOG4105KWW Biogenesis protein M479_691 ENOG410903C (LipO)protein M479_692 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation M479_693 ENOG4105KZW UPF0381 protein M479_696 ENOG4108BY2 phosphohistidine phosphatase M479_698 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) M479_70 ENOG41090R7 Ferric uptake M479_701 ENOG4105EJ9 Membrane M479_702 ENOG4108BPE -transporting atpase M479_703 ENOG4105MH2 YfcL protein M479_705 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) M479_708 ENOG4106WZ1 flagella biosynthesis regulator M479_709 ENOG410631K Membrane M479_71 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) M479_712 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) M479_714 ENOG4105DQR SNARE associated Golgi M479_716 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase M479_717 ENOG4108S3P Sporulation domain protein M479_718 ENOG4105E96 Colicin v production protein M479_719 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase M479_72 ENOG4105NNH LexA regulated protein M479_720 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase M479_721 ENOG4105E89 ABC transporter M479_722 ENOG4105DSP amino acid AbC transporter M479_723 ENOG4106YG3 ABC transporter M479_724 ENOG4108JEH abc transporter atp-binding protein M479_725 ENOG4105ECP epimerase M479_727 ENOG4108RE9 Phosphodiesterase M479_728 ENOG4108RE9 Phosphodiesterase M479_729 ENOG4105PTV Nudix Hydrolase M479_730 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC M479_733 ENOG4107P2S Transcriptional regulator M479_734 ENOG4105C6K Malic enzyme M479_738 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 M479_739 ENOG4107QWE )-transporter M479_74 ENOG4105EV9 Alpha Beta Hydrolase M479_741 ENOG4105CHM Aminotransferase M479_742 ENOG4107NQ8 LysR family Transcriptional regulator M479_744 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) M479_746 ENOG4105GKE subunit e M479_747 ENOG4107QIZ NADH dehydrogenase M479_748 ENOG4108IEH NADH dehydrogenase subunit g M479_751 ENOG4107UFS subunit j M479_753 ENOG4105D65 subunit l M479_754 ENOG4105C8S subunit m M479_757 ENOG4108R66 Conserved Protein M479_758 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family M479_759 ENOG4105CHR reductase M479_760 ENOG4105F32 YngK protein M479_761 ENOG4105K2J Transcriptional regulator M479_762 ENOG4105C5I Dehydrogenase M479_765 ENOG4105C01 Dihydroxy-acid dehydratase M479_767 ENOG4105TNS Conserved Protein M479_769 ENOG4105E4F Isochorismate synthase M479_77 ENOG4105DFP Integrase M479_772 ENOG4108IPT Naphthoate synthase M479_774 ENOG4105CEY Amp-dependent synthetase and ligase M479_775 ENOG4108MTB glycosyl transferase family M479_776 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction M479_778 ENOG4107SDU Methyl-accepting chemotaxis M479_779 ENOG4105CDA abc transporter atp-binding protein M479_780 ENOG4105E5Q amino acid AbC transporter M479_781 ENOG4107R0W ABC transporter M479_787 ENOG4108T1M outer membrane protein x M479_791 ENOG4105CPQ Dehydrogenase M479_792 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M479_794 ENOG4105C2J ABC transporter M479_795 ENOG4105CNN ABC, transporter M479_796 ENOG4105FKQ transcriptional regulator M479_797 ENOG4105EJC lysr family transcriptional regulator M479_798 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) M479_799 ENOG4105C94 Transporter M479_8 ENOG4105C26 Dehydrogenase M479_800 ENOG4105DVW rieske (2Fe-2S) M479_801 ENOG4105E3J oxidoreductase M479_802 ENOG4105D5K Hemolysin activator protein M479_803 ENOG4105CKT filamentous hemagglutinin M479_806 ENOG4105CKT filamentous hemagglutinin M479_81 ENOG4105VUH addiction module killer protein M479_810 ENOG4105CKT filamentous hemagglutinin M479_813 ENOG4108IJ9 (ABC) transporter M479_815 ENOG4105ETE Transcriptional regulator (LacI family M479_818 ENOG4105DRS transport system, permease M479_819 ENOG4105HY2 Glycosidase related protein M479_823 ENOG4105CUY Mechanosensitive ion channel M479_824 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) M479_825 ENOG4107IIZ CRISPR-associated helicase, Cas3 M479_826 ENOG4105ENG CRISPR-associated protein, Csy1 family M479_827 ENOG4105DZX CRISPR-associated protein, Csy2 family M479_828 ENOG4105M6W Crispr-associated protein, Csy3 family M479_829 ENOG4108Y1S CRISPR-associated protein, Csy4 family M479_830 ENOG4105CPC Aldo Keto reductase M479_832 ENOG4105C54 Major Facilitator superfamily M479_834 ENOG4105ETT transcriptional Regulator, LysR family M479_835 ENOG4107YC3 synthase M479_836 ENOG4105VJY transcriptional regulator M479_840 ENOG4105DSF transport protein M479_843 ENOG4105PVA Biofilm formation regulatory protein BssS M479_847 ENOG41067V3 Antibiotic biosynthesis monooxygenase M479_848 ENOG4107QQB Ribonuclease E M479_849 ENOG4105EI2 Pseudouridine synthase M479_851 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein M479_852 ENOG4105VGS 50s ribosomal protein l32 M479_855 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase M479_856 ENOG4105CHR reductase M479_858 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) M479_859 ENOG4108RS6 transposase M479_860 ENOG4105YAZ 4-amino-4-deoxychorismate lyase M479_861 ENOG4105HHA aminodeoxychorismate lyase M479_863 ENOG4107QRG dna polymerase iii M479_864 ENOG4105F8V Hydrolase, tatD family M479_865 ENOG4105CI1 PTS System M479_867 ENOG4105F9E Shikimate 5-dehydrogenase M479_868 ENOG4105K59 histidine triad (HIT) protein M479_869 ENOG41090DQ Lipoprotein M479_872 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) M479_874 ENOG4105CEP NADH dehydrogenase M479_878 ENOG4107MBR 17 kDa surface antigen M479_879 ENOG4108JA2 transcriptioN-repair coupling factor M479_880 ENOG4105D60 lipoprotein releasing system transmembrane protein M479_882 ENOG4105D60 lipoprotein releasing system transmembrane protein M479_884 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) M479_886 ENOG4105EZE Cupin 4 family protein M479_888 ENOG4105XJC Two component transcriptional regulator (Winged helix family M479_890 ENOG4107QTF adenylosuccinate lyase M479_894 ENOG4108R99 pseudouridine synthase M479_895 ENOG4108HMX isocitrate dehydrogenase (NADP) M479_896 ENOG4106NDP Transcriptional regulator M479_898 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor M479_899 ENOG4105ECR NmrA family M479_9 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) M479_900 ENOG4105KVH Transcriptional regulator M479_902 ENOG4105D6F Phosphatase M479_903 ENOG41061EV selenium-binding protein YdfZ M479_905 ENOG4108XM1 transcriptional regulator AsnC family M479_906 ENOG4105GSJ Inner membrane protein ylaC M479_91 ENOG4105DFP Integrase M479_910 ENOG4105VEQ Cold shock protein M479_912 ENOG4105C8Q Methyl-accepting chemotaxis M479_913 ENOG4105C8Q Methyl-accepting chemotaxis M479_915 ENOG4105KT7 mgtC SapB transporter M479_916 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic M479_917 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) M479_918 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region M479_919 ENOG4107RD7 Flagellar Motor Protein, MotA M479_920 ENOG4105ER2 Ompa motb domain protein M479_921 ENOG4105CBS Chea signal transduction histidine kinase M479_922 ENOG4108V3W Chemotaxis protein, CheW M479_923 ENOG4105R9B Major Facilitator M479_924 ENOG4105KME endoribonuclease L-psp M479_926 ENOG4105WWK YheO domain protein M479_930 ENOG4105C8Q Methyl-accepting chemotaxis M479_931 ENOG4105C8Q Methyl-accepting chemotaxis M479_932 ENOG4105BZU Histidine kinase M479_934 ENOG4108VYJ response regulator receiver protein M479_935 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) M479_936 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase M479_937 ENOG4105EUR Domain-Containing protein M479_938 ENOG4105EUR Domain-Containing protein M479_94 ENOG4108Z1B Cyclase dehydrase M479_941 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) M479_950 ENOG4105WT8 Protein of unknown function (DUF1480) M479_953 ENOG4105GQR Chaperone M479_957 ENOG4105DY2 Paraquat-inducible protein b M479_958 ENOG4105H2K paraquat-inducible protein a M479_959 ENOG4108ZGC gaf domain protein M479_96 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) M479_961 ENOG4105CN1 protease M479_964 ENOG4105H8W Fimbrial protein M479_965 ENOG4108VEV chaperone M479_968 ENOG4108VEV chaperone M479_969 ENOG4105C0R drug resistance transporter emrb qaca subfamily M479_97 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) M479_970 ENOG4105CAZ oligogalacturonide lyase M479_972 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase M479_973 ENOG4108ETY sodium dicarboxylate symporter M479_974 ENOG4107K5X Membrane-bound metal-dependent hydrolase M479_975 ENOG4108PU9 oligogalacturonate-specific porin M479_976 ENOG4105WEM extracellular solute-binding protein M479_978 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component M479_979 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component M479_98 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) M479_980 ENOG41061NF Pectate lyase M479_981 ENOG4105CHR reductase M479_983 ENOG4105M5J Cupin 2, conserved barrel domain protein M479_985 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 M479_986 ENOG4107PN8 YfeABCD locus regulator M479_987 ENOG4105FGM Fructosamine kinase M479_988 ENOG4105CC5 ABC transporter M479_989 ENOG4105CC5 ABC transporter M479_990 ENOG4105DIK (ABC) transporter M479_991 ENOG4105DSE periplasmic solute binding protein M479_995 ENOG41087WU