locus-tag	class	description
M481_1	COG0849	cell division
M481_10	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M481_100	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
M481_1002	COG0557	exoribonuclease II activity
M481_1003	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M481_1004	COG1960	acyl-CoA dehydrogenase activity
M481_1005	COG3650	response to hydrogen peroxide
M481_1008	COG1073	alpha beta
M481_1011	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M481_1015	COG3061	Opacity-associated protein A
M481_1016	COG0545	Peptidyl-prolyl cis-trans isomerase
M481_1018	COG0737	Belongs to the 5'-nucleotidase family
M481_102	COG0741	lytic transglycosylase activity
M481_1020	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M481_1022	COG1253	flavin adenine dinucleotide binding
M481_1024	COG0729	surface antigen
M481_1025	COG2911	Protein conserved in bacteria
M481_1026	COG2105	PFAM AIG2 family protein
M481_1027	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M481_1029	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M481_1033	COG3423	Transcriptional regulator
M481_1035	COG0142	geranyltranstransferase activity
M481_1038	COG0697	spore germination
M481_1040	COG0642	Histidine kinase
M481_1041	COG0745	RESPONSE REGULATOR receiver
M481_1042	COG2027	D-alanyl-D-alanine carboxypeptidase
M481_1043	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M481_1044	COG1534	Rna-binding protein
M481_1046	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M481_1047	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M481_1049	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M481_105	COG2199	diguanylate cyclase activity
M481_1053	COG0195	Participates in both transcription termination and antitermination
M481_1058	COG2801	Transposase and inactivated derivatives
M481_106	COG2885	chlorophyll binding
M481_1062	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M481_1066	COG1629	transport
M481_107	COG0488	(ABC) transporter
M481_1071	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M481_1072	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M481_1072	COG0678	peroxiredoxin activity
M481_1086	COG5544	Lipoprotein
M481_1087	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M481_1088	COG0045	succinate-CoA ligase (ADP-forming) activity
M481_1088	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M481_1088	COG1042	CoA-binding domain protein
M481_1090	COG3118	belongs to the thioredoxin family
M481_1091	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M481_1092	COG2814	Major facilitator Superfamily
M481_1093	COG1566	PFAM secretion protein HlyD family protein
M481_1094	COG1846	Transcriptional regulator
M481_1096	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M481_1097	COG2814	Major facilitator Superfamily
M481_11	COG0768	penicillin binding
M481_1106	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M481_1109	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M481_1112	COG0436	Aminotransferase
M481_112	COG0560	Phosphoserine phosphatase
M481_1120	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
M481_1123	COG1960	acyl-CoA dehydrogenase activity
M481_1125	COG3034	peptidoglycan biosynthetic process
M481_1126	COG0121	glutamine amidotransferase
M481_1127	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M481_1128	COG1805	sodium ion transport
M481_1129	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M481_113	COG3726	membrane protein affecting hemolysin expression
M481_1133	COG1477	protein flavinylation
M481_1137	COG2195	Cleaves the N-terminal amino acid of tripeptides
M481_1148	COG2226	methyltransferase
M481_1153	COG1940	carbohydrate kinase activity
M481_1154	COG0419	ATPase involved in DNA repair
M481_1155	COG0420	3'-5' exonuclease activity
M481_1156	COG0745	RESPONSE REGULATOR receiver
M481_1157	COG5002	protein histidine kinase activity
M481_1159	COG1114	Component of the transport system for branched-chain amino acids
M481_1161	COG0366	Alpha amylase catalytic
M481_1165	COG0450	alkyl hydroperoxide reductase
M481_1166	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M481_1167	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M481_1169	COG1862	Preprotein translocase
M481_117	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M481_1170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M481_1171	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M481_1176	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M481_1176	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M481_1179	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M481_118	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M481_1180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M481_1183	COG0142	geranyltranstransferase activity
M481_1186	COG0693	protein deglycase activity
M481_1187	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M481_1189	COG2814	Major facilitator Superfamily
M481_119	COG0084	hydrolase, TatD family'
M481_1191	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M481_1192	COG1845	cytochrome c oxidase, subunit III
M481_1193	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M481_1194	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M481_1196	COG2223	nitrite transmembrane transporter activity
M481_1197	COG3056	Lipoprotein
M481_1198	COG0271	Belongs to the BolA IbaG family
M481_12	COG3116	cell division
M481_120	COG4667	esterase of the alpha-beta hydrolase superfamily
M481_1203	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M481_1204	COG0776	regulation of translation
M481_1206	COG1943	Transposase
M481_1207	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M481_1208	COG1555	photosystem II stabilization
M481_1209	COG0824	Thioesterase
M481_1211	COG4533	DNA binding
M481_1214	COG1522	sequence-specific DNA binding
M481_1215	COG1132	(ABC) transporter
M481_1216	COG1132	(ABC) transporter
M481_1217	COG0347	Belongs to the P(II) protein family
M481_1218	COG0004	ammonium transporteR
M481_1219	COG1946	Acyl-CoA thioesterase
M481_122	COG2823	Periplasmic or secreted lipoprotein
M481_1220	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M481_1221	COG3695	enzyme binding
M481_1225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M481_1227	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M481_1228	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M481_1229	COG1309	transcriptional regulator
M481_1230	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M481_1231	COG3264	Mechanosensitive ion channel
M481_1231	COG1196	nuclear chromosome segregation
M481_1233	COG2832	Protein of unknown function (DUF454)
M481_1235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M481_124	COG0456	acetyltransferase
M481_1241	COG0543	2 iron, 2 sulfur cluster binding
M481_1241	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M481_1245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M481_125	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
M481_1253	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
M481_1254	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
M481_1255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M481_1259	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M481_1260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M481_1261	COG4651	solute:proton antiporter activity
M481_1261	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M481_1262	COG2223	nitrite transmembrane transporter activity
M481_1263	COG2223	nitrite transmembrane transporter activity
M481_1264	COG0737	Belongs to the 5'-nucleotidase family
M481_1265	COG0737	Belongs to the 5'-nucleotidase family
M481_1266	COG0737	Belongs to the 5'-nucleotidase family
M481_1269	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M481_1270	COG3735	TraB family
M481_1271	COG2217	Heavy metal translocating P-type atpase
M481_1272	COG0789	Transcriptional regulator
M481_1273	COG1585	Membrane protein implicated in regulation of membrane protease activity
M481_1274	COG0330	HflC and HflK could
M481_1275	COG3118	belongs to the thioredoxin family
M481_1276	COG0300	oxidoreductase activity
M481_1277	COG2755	lipolytic protein G-D-S-L family
M481_1278	COG4181	ATPase activity
M481_1279	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M481_1280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M481_1281	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M481_1283	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M481_1286	COG2501	S4 domain
M481_129	COG3706	GGDEF domain
M481_1293	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M481_1294	COG4589	Belongs to the CDS family
M481_1296	COG2267	carboxylic ester hydrolase activity
M481_1297	COG0671	phosphoesterase, PA-phosphatase related
M481_1297	COG2453	phosphatase
M481_1304	COG0667	Aldo Keto reductase
M481_1305	COG0656	L-ascorbic acid biosynthetic process
M481_1311	COG3328	transposase activity
M481_1312	COG2850	peptidyl-arginine hydroxylation
M481_132	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M481_1321	COG3423	Transcriptional regulator
M481_1322	COG4953	penicillin-binding protein 1C
M481_1323	COG2373	Large extracellular alpha-helical protein
M481_1329	COG3962	Belongs to the TPP enzyme family
M481_133	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M481_1330	COG0673	inositol 2-dehydrogenase activity
M481_1331	COG0673	inositol 2-dehydrogenase activity
M481_1332	COG1879	ABC-type sugar transport system periplasmic component
M481_1333	COG1129	ABC transporter
M481_1334	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_1335	COG0673	inositol 2-dehydrogenase activity
M481_1336	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M481_1338	COG3718	enzyme involved in inositol metabolism
M481_1340	COG5265	(ABC) transporter
M481_1345	COG2197	response regulator
M481_1346	COG1278	Cold shock
M481_1347	COG1278	Cold shock
M481_1348	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M481_1349	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M481_1353	COG1686	Belongs to the peptidase S11 family
M481_1354	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M481_1355	COG0772	Belongs to the SEDS family
M481_1356	COG0768	penicillin binding
M481_1358	COG0799	negative regulation of ribosome biogenesis
M481_136	COG0859	PFAM glycosyl transferase family 9
M481_1360	COG1466	dna polymerase III delta subunit
M481_1363	COG2888	peptidyl-tyrosine sulfation
M481_1364	COG1126	abc transporter atp-binding protein
M481_1365	COG0765	amino acid transport
M481_1366	COG0765	amino acid transport
M481_1368	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M481_1369	COG4535	Mg2 and Co2 transporter CorC
M481_1371	COG1702	phosphate starvation-inducible protein PhoH
M481_1373	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M481_138	COG2390	Transcriptional regulator
M481_1380	COG0367	asparagine synthase
M481_1381	COG0647	UMP catabolic process
M481_1382	COG1940	carbohydrate kinase activity
M481_1382	COG1846	Transcriptional regulator
M481_1383	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M481_1385	COG2190	(PTS) system
M481_1385	COG1263	PTS System
M481_1385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M481_1390	COG0735	belongs to the Fur family
M481_1394	COG0596	Alpha beta hydrolase
M481_1396	COG2963	transposase activity
M481_1397	COG0582	viral genome integration into host DNA
M481_1402	COG3657	addiction module killer protein
M481_1412	COG0582	viral genome integration into host DNA
M481_1415	COG2867	negative regulation of translational initiation
M481_1417	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M481_1418	COG0497	DNA recombination
M481_1419	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M481_1422	COG2009	succinate dehydrogenase
M481_1423	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M481_1424	COG1053	succinate dehydrogenase
M481_1426	COG0567	Dehydrogenase, E1 component
M481_1427	COG0508	dehydrogenase complex catalyzes the overall conversion of
M481_1429	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M481_1430	COG1943	Transposase
M481_1431	COG1271	oxidase subunit
M481_1432	COG1294	oxidase, subunit
M481_1433	COG4890	Cyd operon protein YbgT
M481_1434	COG3790	cyd operon protein YbgE
M481_1435	COG0824	Thioesterase
M481_1436	COG0811	peptide transport
M481_1437	COG0848	biopolymer transport protein
M481_1438	COG3064	Membrane
M481_1438	COG3064	Membrane
M481_1440	COG2885	chlorophyll binding
M481_1441	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M481_1447	COG1230	cation diffusion facilitator family transporter
M481_1448	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M481_1449	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M481_1452	COG2017	converts alpha-aldose to the beta-anomer
M481_1455	COG1085	galactose-1-phosphate uridylyltransferase
M481_1456	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M481_146	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M481_146	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M481_146	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M481_1460	COG1119	ATPase activity
M481_1461	COG3585	molybdate ion transport
M481_1461	COG2005	Transcriptional regulator
M481_1463	COG0725	ABC transporter, periplasmic molybdate-binding protein
M481_1464	COG4149	molybdate abc transporter
M481_1466	COG0561	phosphatase activity
M481_147	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M481_1471	COG2226	methyltransferase
M481_1472	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M481_1474	COG0556	nucleotide-excision repair
M481_1475	COG4628	conserved protein (DUF2132)
M481_1476	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M481_1478	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M481_148	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M481_1480	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M481_1481	COG0314	molybdopterin synthase activity
M481_1482	COG0670	Belongs to the BI1 family
M481_1483	COG1943	Transposase
M481_1487	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M481_1488	COG0583	DNA-binding transcription factor activity
M481_149	COG2207	Transcriptional regulator
M481_1490	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M481_1491	COG2211	Major facilitator Superfamily
M481_1494	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M481_1496	COG1686	Belongs to the peptidase S11 family
M481_1497	COG0277	FAD linked oxidase domain protein
M481_1499	COG1403	HNH endonuclease
M481_150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M481_1501	COG2261	transglycosylase associated protein
M481_1503	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
M481_1506	COG4807	Protein conserved in bacteria
M481_1510	COG1122	ATPase activity
M481_1511	COG0410	ABC transporter
M481_1514	COG2897	thiosulfate sulfurtransferase activity
M481_1515	COG1732	Glycine betaine
M481_1516	COG1174	glycine betaine transport
M481_1517	COG1125	glycine betaine transport
M481_1518	COG1174	glycine betaine transport
M481_1519	COG0531	amino acid
M481_152	COG4269	membrane
M481_1520	COG1982	Orn Lys Arg decarboxylase major
M481_1521	COG3328	transposase activity
M481_1522	COG1982	Orn Lys Arg decarboxylase major
M481_1524	COG0697	spore germination
M481_1529	COG0814	amino acid
M481_1532	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M481_1537	COG2205	protein histidine kinase activity
M481_1537	COG0784	Response regulator, receiver
M481_1539	COG0642	Histidine kinase
M481_1539	COG2198	Histidine kinase
M481_1540	COG2198	Histidine kinase
M481_1540	COG0642	Histidine kinase
M481_1541	COG2223	nitrite transmembrane transporter activity
M481_1542	COG2223	nitrite transmembrane transporter activity
M481_1544	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M481_1547	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M481_1556	COG3395	kinase activity
M481_1557	COG0235	Class ii aldolase
M481_1558	COG1349	DNA-binding transcription factor activity
M481_1559	COG3622	Belongs to the hyi family
M481_1563	COG4386	tail sheath protein
M481_1572	COG3299	homolog of phage Mu protein gp47
M481_1576	COG1737	Transcriptional regulator
M481_1578	COG2723	6-phospho-beta-galactosidase activity
M481_1582	COG3157	Type VI secretion system effector, Hcp
M481_1585	COG3083	sulfuric ester hydrolase activity
M481_1586	COG3082	Protein of unknown function (DUF1414)
M481_1588	COG1943	Transposase
M481_1590	COG1061	Type III restriction enzyme res subunit
M481_1591	COG1187	pseudouridine synthase activity
M481_1592	COG2814	Major facilitator Superfamily
M481_1594	COG4172	Belongs to the ABC transporter superfamily
M481_1595	COG4239	(ABC) transporter, permease
M481_1596	COG4174	ABC transporter (Permease)
M481_1597	COG4166	transmembrane transport
M481_1598	COG2200	EAL domain
M481_1600	COG0791	NLP P60 protein
M481_1601	COG0671	phosphoesterase, PA-phosphatase related
M481_1602	COG0523	cobalamin synthesis protein
M481_1604	COG2186	Transcriptional regulator
M481_1605	COG0246	Mannitol dehydrogenase
M481_1606	COG1312	Catalyzes the dehydration of D-mannonate
M481_161	COG2963	transposase activity
M481_1610	COG1028	Short-chain dehydrogenase reductase Sdr
M481_1615	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M481_1617	COG1129	ABC transporter
M481_1618	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_1619	COG0494	nUDIX hydrolase
M481_1621	COG1105	Belongs to the carbohydrate kinase PfkB family
M481_1622	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M481_1622	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M481_1622	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M481_1623	COG3710	Transcriptional regulator
M481_1626	COG3121	Chaperone
M481_1627	COG3188	usher protein
M481_1629	COG2855	membrane
M481_163	COG1401	restriction endodeoxyribonuclease activity
M481_1630	COG0583	DNA-binding transcription factor activity
M481_1632	COG0833	amino acid
M481_1635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M481_1637	COG4771	TonB-dependent receptor
M481_1638	COG0625	glutathione transferase activity
M481_1644	COG2011	ABC-type metal ion transport system permease component
M481_1645	COG1686	Belongs to the peptidase S11 family
M481_1646	COG0814	amino acid
M481_1647	COG1349	DNA-binding transcription factor activity
M481_1648	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M481_1649	COG0671	phosphoesterase, PA-phosphatase related
M481_1651	COG2985	domain, Protein
M481_1651	COG0569	domain protein
M481_1652	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M481_1655	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M481_1656	COG3842	ATPase activity
M481_1657	COG1176	ABC-type spermidine putrescine transport system, permease component I
M481_1658	COG1177	transmembrane transport
M481_1661	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M481_1666	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M481_1667	COG1120	ATPase activity
M481_1671	COG4160	amino acid transport
M481_1672	COG4215	(ABC) transporter
M481_1673	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M481_1674	COG1126	abc transporter atp-binding protein
M481_1675	COG1605	Chorismate mutase
M481_1677	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M481_1678	COG0702	epimerase
M481_1679	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M481_168	COG0582	viral genome integration into host DNA
M481_1680	COG0028	Belongs to the TPP enzyme family
M481_1681	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M481_1683	COG2431	L-lysine efflux transmembrane transporter activity
M481_1684	COG3593	DNA synthesis involved in DNA repair
M481_1685	COG2990	Protein conserved in bacteria
M481_1686	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M481_1688	COG1278	Cold shock
M481_1690	COG0542	response to heat
M481_1692	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M481_1694	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M481_1696	COG0492	ferredoxin-NADP+ reductase activity
M481_1698	COG1674	ftsk spoiiie
M481_1698	COG3107	peptidoglycan biosynthetic process
M481_17	COG1609	Transcriptional regulator
M481_170	COG0795	lipopolysaccharide-transporting ATPase activity
M481_1701	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M481_1703	COG2814	Major facilitator Superfamily
M481_1704	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M481_1706	COG1882	Formate acetyltransferase
M481_1707	COG2116	formate transmembrane transporter activity
M481_1708	COG1944	ATP diphosphatase activity
M481_1709	COG0252	asparaginase activity
M481_171	COG0795	lipopolysaccharide-transporting ATPase activity
M481_1710	COG5295	Hep Hag repeat protein
M481_1710	COG5295	Hep Hag repeat protein
M481_1715	COG0539	negative regulation of cytoplasmic translation
M481_1718	COG2333	competence protein COMEC
M481_1718	COG0658	competence protein
M481_1721	COG5383	Protein conserved in bacteria
M481_1722	COG1278	Cold shock
M481_1723	COG2835	tetraacyldisaccharide 4'-kinase activity
M481_1725	COG3173	Aminoglycoside phosphotransferase
M481_1726	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M481_1727	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
M481_1728	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M481_173	COG2927	DNA polymerase III (CHI subunit)
M481_1731	COG2989	Protein conserved in bacteria
M481_1732	COG3108	Peptidase M15
M481_1733	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M481_1734	COG1448	Aminotransferase
M481_1738	COG0308	aminopeptidase N
M481_174	COG0525	valine-tRNA ligase activity
M481_1741	COG3217	Mosc domain protein beta barrel domain protein
M481_1741	COG0633	Ferredoxin
M481_1743	COG0488	(ABC) transporter
M481_1744	COG2995	paraquat-inducible protein a
M481_1745	COG3008	intermembrane lipid transfer
M481_1745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M481_1746	COG3009	Protein conserved in bacteria
M481_1747	COG1943	Transposase
M481_1748	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M481_1749	COG1737	Transcriptional regulator
M481_1751	COG0560	Phosphoserine phosphatase
M481_1752	COG0590	tRNA wobble adenosine to inosine editing
M481_1758	COG1943	Transposase
M481_1759	COG2205	protein histidine kinase activity
M481_176	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
M481_1760	COG3170	Tfp pilus assembly protein FimV
M481_1761	COG2204	response regulator
M481_1762	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M481_1762	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M481_1763	COG0347	Belongs to the P(II) protein family
M481_1764	COG2188	Transcriptional regulator
M481_1767	COG1017	nitric oxide dioxygenase activity
M481_1767	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M481_177	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M481_1770	COG3711	transcriptional antiterminator
M481_1771	COG2814	Major facilitator Superfamily
M481_1772	COG3683	transport system, periplasmic component
M481_1773	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
M481_1774	COG0483	inositol monophosphate 1-phosphatase activity
M481_1777	COG1104	cysteine desulfurase activity
M481_1778	COG0822	iron-sulfur transferase activity
M481_178	COG2731	YhcH YjgK YiaL family protein
M481_1781	COG0443	Heat shock 70 kDa protein
M481_1782	COG0633	Ferredoxin
M481_1783	COG2975	iron-sulfur cluster assembly
M481_1787	COG3468	outer membrane autotransporter barrel domain protein
M481_1788	COG3468	outer membrane autotransporter barrel domain protein
M481_1796	COG2976	Protein conserved in bacteria
M481_1797	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M481_18	COG1943	Transposase
M481_1800	COG1645	bacterial-type flagellum-dependent swarming motility
M481_1802	COG0516	GMP reductase activity
M481_1802	COG0517	IMP dehydrogenase activity
M481_1804	COG1943	Transposase
M481_181	COG0601	transmembrane transport
M481_1811	COG3328	transposase activity
M481_1814	COG0351	phosphomethylpyrimidine kinase
M481_1819	COG3422	double-strand break repair
M481_182	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M481_1820	COG0745	RESPONSE REGULATOR receiver
M481_1821	COG2205	protein histidine kinase activity
M481_1827	COG3842	ATPase activity
M481_1829	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M481_183	COG0444	Belongs to the ABC transporter superfamily
M481_1831	COG1176	ABC-type spermidine putrescine transport system, permease component I
M481_1832	COG1177	transmembrane transport
M481_1833	COG0443	Heat shock 70 kDa protein
M481_1834	COG2239	Acts as a magnesium transporter
M481_1835	COG0248	Ppx GppA phosphatase
M481_1836	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M481_1838	COG0581	inorganic phosphate transmembrane transporter activity
M481_184	COG4608	Belongs to the ABC transporter superfamily
M481_1842	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M481_1843	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M481_1846	COG1943	Transposase
M481_1848	COG1393	Belongs to the ArsC family
M481_1849	COG4783	chaperone-mediated protein folding
M481_1850	COG0628	permease
M481_1853	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M481_1854	COG2716	regulation of RNA biosynthetic process
M481_1856	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M481_1857	COG1943	Transposase
M481_1859	COG2321	neutral zinc metallopeptidase
M481_1863	COG1876	peptidase activity
M481_1865	COG1393	Belongs to the ArsC family
M481_1867	COG1840	ABC-type Fe3 transport system, periplasmic component
M481_1868	COG1175	transmembrane transport
M481_1869	COG3842	ATPase activity
M481_1870	COG3119	arylsulfatase activity
M481_1871	COG0641	radical SAM
M481_1872	COG1988	membrane-bound metal-dependent
M481_1874	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M481_1876	COG2197	response regulator
M481_1877	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
M481_1877	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M481_1878	COG3062	negative regulation of establishment of protein localization
M481_188	COG2188	Transcriptional regulator
M481_1880	COG3043	anaerobic respiration
M481_1881	COG3005	denitrification pathway
M481_1889	COG1943	Transposase
M481_189	COG3624	Phosphonate C-P lyase system protein PhnG
M481_1891	COG3111	PFAM Bacterial OB fold (BOF) protein
M481_1894	COG2837	iron assimilation
M481_1895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M481_1897	COG4886	Leucine-rich repeat (LRR) protein
M481_1899	COG2731	YhcH YjgK YiaL family protein
M481_190	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
M481_1900	COG1737	Transcriptional regulator
M481_1902	COG4150	thiosulfate binding
M481_1903	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M481_1904	COG4208	sulfate ABC transporter
M481_1905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M481_1908	COG0745	RESPONSE REGULATOR receiver
M481_1909	COG3850	Histidine kinase
M481_1909	COG5002	protein histidine kinase activity
M481_191	COG3626	phosphonate metabolism
M481_1911	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M481_1913	COG0006	proline dipeptidase activity
M481_1915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M481_1918	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M481_1919	COG0745	RESPONSE REGULATOR receiver
M481_192	COG3627	carbon phosphorus lyase activity
M481_1920	COG2205	protein histidine kinase activity
M481_1923	COG2190	(PTS) system
M481_1925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M481_1926	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M481_1927	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M481_193	COG4107	phosphonate C-P lyase system protein PhnK
M481_1930	COG3530	Putative quorum-sensing-regulated virulence factor
M481_1933	COG1943	Transposase
M481_194	COG4778	phosphonate C-P lyase system protein PhnL
M481_1940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M481_1943	COG0667	Aldo Keto reductase
M481_1948	COG0436	Aminotransferase
M481_1949	COG3038	cytochrome b561
M481_195	COG3454	Phosphonate metabolism
M481_1955	COG3381	protein complex oligomerization
M481_1956	COG3302	dmso reductase anchor subunit
M481_1957	COG0437	4 iron, 4 sulfur cluster binding
M481_1958	COG0243	molybdopterin cofactor binding
M481_196	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
M481_1965	COG2951	lytic endotransglycosylase activity
M481_197	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M481_1977	COG3121	Chaperone
M481_1978	COG3188	usher protein
M481_1979	COG3328	transposase activity
M481_198	COG0702	epimerase
M481_1980	COG3188	usher protein
M481_1994	COG3501	Rhs element vgr protein
M481_2	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M481_20	COG0028	Belongs to the TPP enzyme family
M481_2000	COG2824	Alkylphosphonate utilization operon protein PhnA
M481_2002	COG1704	LemA family
M481_2006	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M481_2007	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M481_2008	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M481_201	COG3842	ATPase activity
M481_2010	COG1138	Cytochrome C-type biogenesis protein
M481_2011	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M481_2012	COG3088	subunit of a heme lyase
M481_2012	COG4235	cytochrome complex assembly
M481_2013	COG4235	cytochrome complex assembly
M481_2013	COG3088	subunit of a heme lyase
M481_2016	COG3691	Protein conserved in bacteria
M481_2019	COG2062	phosphohistidine phosphatase, SixA
M481_202	COG0395	ABC-type sugar transport system, permease component
M481_2021	COG2890	protein-(glutamine-N5) methyltransferase activity
M481_2024	COG0730	response to heat
M481_2025	COG3101	peptidyl-lysine hydroxylation
M481_2028	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M481_2029	COG1794	racemase activity, acting on amino acids and derivatives
M481_2032	COG0697	spore germination
M481_2035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M481_2037	COG0586	Pfam SNARE associated Golgi protein
M481_2039	COG0285	dihydrofolate synthase activity
M481_204	COG1653	transport
M481_2040	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M481_2041	COG1286	toxin biosynthetic process
M481_2042	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M481_2043	COG0163	prenyltransferase activity
M481_2044	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M481_2045	COG4215	(ABC) transporter
M481_2046	COG4160	amino acid transport
M481_2047	COG4598	ABC transporter
M481_2048	COG1090	epimerase
M481_2050	COG0622	Phosphoesterase
M481_2051	COG0622	Phosphoesterase
M481_2052	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M481_2053	COG3037	sugar-specific permease SgaT UlaA
M481_2056	COG1609	Transcriptional regulator
M481_2057	COG0280	phosphate acetyltransferase
M481_2057	COG0857	belongs to the CobB CobQ family
M481_2061	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M481_2062	COG0471	metal ion transport
M481_2062	COG0490	domain, Protein
M481_2064	COG0436	Aminotransferase
M481_2065	COG0583	DNA-binding transcription factor activity
M481_2067	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M481_2069	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M481_2071	COG1034	ATP synthesis coupled electron transport
M481_2074	COG0839	Belongs to the complex I subunit 6 family
M481_2076	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M481_2077	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M481_208	COG3153	acetyltransferase
M481_2080	COG2731	YhcH YjgK YiaL family protein
M481_2081	COG3265	gluconokinase activity
M481_2082	COG1028	Short-chain dehydrogenase reductase Sdr
M481_2084	COG1609	Transcriptional regulator
M481_2085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M481_2088	COG0129	dihydroxy-acid dehydratase activity
M481_2090	COG4575	ribosome binding
M481_2092	COG1169	isochorismate synthase
M481_2095	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M481_2098	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M481_21	COG3328	transposase activity
M481_2102	COG1126	abc transporter atp-binding protein
M481_2103	COG0765	amino acid transport
M481_2104	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M481_2110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M481_2114	COG1063	alcohol dehydrogenase
M481_2115	COG1879	ABC-type sugar transport system periplasmic component
M481_2117	COG1129	ABC transporter
M481_2118	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_2119	COG1609	Transcriptional regulator
M481_2120	COG0583	DNA-binding transcription factor activity
M481_2121	COG0473	3-isopropylmalate dehydrogenase activity
M481_2122	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M481_2123	COG4638	Rieske (2fe-2S)
M481_2124	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M481_2125	COG2831	hemolysin activation secretion protein
M481_2126	COG3210	domain, Protein
M481_2129	COG3210	domain, Protein
M481_213	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M481_2133	COG3210	domain, Protein
M481_2135	COG3842	ATPase activity
M481_2137	COG1609	Transcriptional regulator
M481_2140	COG0395	ABC-type sugar transport system, permease component
M481_2141	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
M481_2145	COG0668	transmembrane transport
M481_2146	COG1518	maintenance of DNA repeat elements
M481_2147	COG1203	CRISPR-associated helicase, Cas3
M481_2152	COG0667	Aldo Keto reductase
M481_2154	COG0477	Major facilitator Superfamily
M481_2156	COG0583	DNA-binding transcription factor activity
M481_2157	COG3916	Acyl-homoserine-lactone synthase
M481_2158	COG2771	luxR family
M481_216	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M481_2162	COG0628	permease
M481_2166	COG3328	transposase activity
M481_2169	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M481_2170	COG1530	ribonuclease E activity
M481_2171	COG0564	pseudouridine synthase activity
M481_2173	COG1399	metal-binding, possibly nucleic acid-binding protein
M481_2174	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M481_2178	COG1028	Short-chain dehydrogenase reductase Sdr
M481_2180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M481_2181	COG1943	Transposase
M481_2182	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M481_2183	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M481_2185	COG0470	DNA polymerase III
M481_2186	COG0084	hydrolase, TatD family'
M481_2187	COG1263	PTS System
M481_2187	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M481_2189	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M481_219	COG0513	Belongs to the DEAD box helicase family
M481_2190	COG0537	adenosine 5'-monophosphoramidase activity
M481_2191	COG5633	Lipoprotein
M481_2194	COG1472	Belongs to the glycosyl hydrolase 3 family
M481_2196	COG1252	NADH dehydrogenase
M481_2199	COG3328	transposase activity
M481_22	COG1022	Amp-dependent synthetase and ligase
M481_2200	COG3134	Outer membrane lipoprotein
M481_2201	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M481_2202	COG4591	ABC-type transport system involved in lipoprotein release permease component
M481_2204	COG4591	ABC-type transport system involved in lipoprotein release permease component
M481_2206	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M481_2208	COG2850	peptidyl-arginine hydroxylation
M481_2210	COG0745	RESPONSE REGULATOR receiver
M481_2212	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M481_2216	COG1187	pseudouridine synthase activity
M481_2217	COG0538	isocitrate dehydrogenase activity
M481_2220	COG0840	transmembrane signaling receptor activity
M481_2221	COG0702	epimerase
M481_2222	COG1733	regulation of RNA biosynthetic process
M481_2227	COG1522	sequence-specific DNA binding
M481_2229	COG0604	alcohol dehydrogenase
M481_2229	COG3321	synthase
M481_2229	COG1028	Short-chain dehydrogenase reductase Sdr
M481_223	COG2801	Transposase and inactivated derivatives
M481_2231	COG1278	Cold shock
M481_2233	COG0840	transmembrane signaling receptor activity
M481_2234	COG0840	transmembrane signaling receptor activity
M481_2235	COG1285	pathogenesis
M481_2240	COG1360	Flagellar Motor Protein
M481_2241	COG2198	Histidine kinase
M481_2241	COG0643	Histidine kinase
M481_2242	COG0835	chemotaxis
M481_2243	COG2271	Major facilitator Superfamily
M481_2244	COG0251	oxidation-reduction process
M481_2246	COG2964	Protein conserved in bacteria
M481_2250	COG0840	transmembrane signaling receptor activity
M481_2251	COG0840	transmembrane signaling receptor activity
M481_2252	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M481_2254	COG0745	RESPONSE REGULATOR receiver
M481_2255	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M481_2256	COG3023	N-Acetylmuramoyl-L-alanine amidase
M481_2258	COG5295	Hep Hag repeat protein
M481_226	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M481_2261	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M481_227	COG0058	SHG alpha-glucan phosphorylase activity
M481_2273	COG3121	Chaperone
M481_2277	COG3008	intermembrane lipid transfer
M481_2278	COG2995	paraquat-inducible protein a
M481_2279	COG1956	GAF domain-containing protein
M481_2281	COG0793	Belongs to the peptidase S41A family
M481_2284	COG3539	Fimbrial protein
M481_2285	COG3121	Chaperone
M481_2288	COG3121	Chaperone
M481_2289	COG2814	Major facilitator Superfamily
M481_229	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M481_2290	COG0823	Involved in the tonB-independent uptake of proteins
M481_2292	COG3023	N-Acetylmuramoyl-L-alanine amidase
M481_2294	COG1988	membrane-bound metal-dependent
M481_2295	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M481_2296	COG1653	transport
M481_2297	COG3842	ATPase activity
M481_2298	COG0395	ABC-type sugar transport system, permease component
M481_2299	COG1175	transmembrane transport
M481_2301	COG1028	Short-chain dehydrogenase reductase Sdr
M481_2303	COG1917	Cupin 2, conserved barrel domain protein
M481_2304	COG3328	transposase activity
M481_2305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M481_2308	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M481_2309	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M481_2310	COG1121	(ABC) transporter
M481_2311	COG0803	Belongs to the bacterial solute-binding protein 9 family
M481_2315	COG4249	Peptidase C14 caspase catalytic subunit p20
M481_232	COG3275	phosphorelay sensor kinase activity
M481_2320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M481_2321	COG0072	phenylalanine-tRNA ligase activity
M481_2321	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M481_2322	COG0776	regulation of translation
M481_2325	COG0386	Belongs to the glutathione peroxidase family
M481_2326	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
M481_2334	COG0791	NLP P60 protein
M481_2339	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M481_2339	COG0574	Belongs to the PEP-utilizing enzyme family
M481_2340	COG0628	permease
M481_2341	COG0247	lactate metabolic process
M481_2341	COG0277	FAD linked oxidase domain protein
M481_2342	COG2050	protein possibly involved in aromatic compounds catabolism
M481_2343	COG0316	Belongs to the HesB IscA family
M481_2344	COG0719	Fe-S assembly protein
M481_2345	COG0396	ATPase activity
M481_2346	COG0719	Fe-S assembly protein
M481_2349	COG1376	ErfK ybiS ycfS ynhG family protein
M481_2349	COG1388	LysM domain
M481_2353	COG4238	major outer membrane lipoprotein
M481_2358	COG0307	riboflavin synthase, alpha
M481_2359	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M481_2360	COG2814	Major facilitator Superfamily
M481_2361	COG0583	DNA-binding transcription factor activity
M481_2364	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M481_2365	COG0791	NLP P60 protein
M481_2367	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M481_2369	COG0346	lactoylglutathione lyase activity
M481_2371	COG1902	pentaerythritol trinitrate reductase activity
M481_2372	COG1309	transcriptional regulator
M481_2373	COG2194	sulfuric ester hydrolase activity
M481_2374	COG3313	Fe-S protein
M481_2375	COG4989	oxidoreductase activity
M481_2377	COG3133	Outer membrane lipoprotein
M481_2379	COG3895	Periplasmic Protein
M481_238	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M481_2383	COG0625	glutathione transferase activity
M481_2386	COG3104	oligopeptide transport
M481_2388	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M481_2388	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M481_2389	COG4172	Belongs to the ABC transporter superfamily
M481_239	COG2095	MarC family integral membrane protein
M481_2391	COG4171	peptide transport system, permease
M481_2392	COG4168	peptide transport system, permease
M481_2393	COG4166	transmembrane transport
M481_2395	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M481_2396	COG1842	Phage shock protein A
M481_2398	COG1983	PspC domain protein
M481_2400	COG3106	COG3106 Predicted ATPase
M481_2408	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M481_2409	COG4948	Mandelate Racemase Muconate Lactonizing
M481_2410	COG2866	Carboxypeptidase
M481_2411	COG4166	transmembrane transport
M481_2414	COG2755	lipolytic protein G-D-S-L family
M481_2414	COG0657	acetylesterase activity
M481_2417	COG0674	pyruvate-flavodoxin oxidoreductase activity
M481_2417	COG1013	pyruvate-flavodoxin oxidoreductase activity
M481_2417	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M481_2417	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M481_2419	COG1285	pathogenesis
M481_2420	COG3042	response to heat
M481_2421	COG3187	Heat shock protein
M481_2422	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M481_2423	COG2911	Protein conserved in bacteria
M481_2425	COG3784	Protein of unknown function (DUF1318)
M481_2426	COG0246	Mannitol dehydrogenase
M481_2427	COG2390	Transcriptional regulator
M481_2429	COG1643	Atp-dependent helicase
M481_243	COG3265	gluconokinase activity
M481_2432	COG3591	Belongs to the peptidase S1B family
M481_2434	COG3038	cytochrome b561
M481_2439	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M481_244	COG2610	gluconate transmembrane transporter activity
M481_2440	COG2205	protein histidine kinase activity
M481_2441	COG0745	RESPONSE REGULATOR receiver
M481_2443	COG0531	amino acid
M481_2445	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M481_2446	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M481_2447	COG0589	response to stress
M481_2448	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M481_2449	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M481_245	COG1609	Transcriptional regulator
M481_2452	COG1011	Hydrolase
M481_2453	COG0440	acetolactate synthase activity
M481_2454	COG0028	Belongs to the TPP enzyme family
M481_246	COG1741	Belongs to the pirin family
M481_2460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M481_2462	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M481_2463	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M481_2464	COG1879	ABC-type sugar transport system periplasmic component
M481_2466	COG1609	Transcriptional regulator
M481_2468	COG0038	chloride channel
M481_2469	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M481_2471	COG1940	carbohydrate kinase activity
M481_2472	COG0583	DNA-binding transcription factor activity
M481_2473	COG2814	Major facilitator Superfamily
M481_2475	COG0114	fumarate hydratase activity
M481_2477	COG5339	Protein conserved in bacteria
M481_2479	COG0385	Bile acid
M481_248	COG0745	RESPONSE REGULATOR receiver
M481_2480	COG0673	inositol 2-dehydrogenase activity
M481_2482	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_2483	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_2485	COG1879	ABC-type sugar transport system periplasmic component
M481_2489	COG2274	protein secretion by the type I secretion system
M481_2490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M481_2492	COG1132	(ABC) transporter
M481_2498	COG3708	Transcriptional regulator
M481_2498	COG2207	Transcriptional regulator
M481_2499	COG4658	electron transport chain
M481_250	COG0191	fructose-bisphosphate aldolase activity
M481_2500	COG4659	FMN binding
M481_2502	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M481_2503	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M481_2504	COG2271	Major facilitator Superfamily
M481_2506	COG1966	Carbon starvation protein
M481_2507	COG2879	small protein
M481_2508	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M481_2512	COG0023	Translation Initiation Factor
M481_2515	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M481_2516	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M481_2517	COG0671	phosphoesterase, PA-phosphatase related
M481_2518	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M481_2519	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M481_252	COG1879	ABC-type sugar transport system periplasmic component
M481_2521	COG0583	DNA-binding transcription factor activity
M481_2522	COG1943	Transposase
M481_2523	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M481_2526	COG0616	signal peptide processing
M481_2527	COG1028	Short-chain dehydrogenase reductase Sdr
M481_2529	COG1187	pseudouridine synthase activity
M481_253	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_2530	COG0009	L-threonylcarbamoyladenylate synthase
M481_2533	COG0512	Glutamine amidotransferase of anthranilate synthase
M481_2535	COG0134	indole-3-glycerol-phosphate synthase activity
M481_2535	COG0135	phosphoribosylanthranilate isomerase activity
M481_2539	COG3047	cAMP biosynthetic process
M481_2544	COG1607	acyl-coa hydrolase
M481_2545	COG3328	transposase activity
M481_2546	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M481_2547	COG2350	Protein conserved in bacteria
M481_2554	COG4608	Belongs to the ABC transporter superfamily
M481_2555	COG0444	Belongs to the ABC transporter superfamily
M481_2556	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M481_2557	COG0601	transmembrane transport
M481_2559	COG2095	MarC family integral membrane protein
M481_256	COG2081	HI0933 family
M481_2560	COG1012	belongs to the aldehyde dehydrogenase family
M481_2560	COG1454	alcohol dehydrogenase
M481_2561	COG1435	thymidine kinase activity
M481_2563	COG3328	transposase activity
M481_2566	COG0745	RESPONSE REGULATOR receiver
M481_2568	COG0788	formyltetrahydrofolate deformylase activity
M481_257	COG0306	phosphate transporter
M481_2571	COG3328	transposase activity
M481_2572	COG0583	DNA-binding transcription factor activity
M481_2573	COG0708	Exodeoxyribonuclease III
M481_2574	COG0494	nUDIX hydrolase
M481_2576	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M481_2577	COG0709	Synthesizes selenophosphate from selenide and ATP
M481_2578	COG0778	Nitroreductase
M481_2579	COG0616	signal peptide processing
M481_2580	COG0252	asparaginase activity
M481_2581	COG1335	isochorismatase
M481_2582	COG3139	Protein of unknown function (DUF1315)
M481_2586	COG3713	MltA-interacting MipA family protein
M481_2587	COG2766	serine protein kinase
M481_2590	COG0583	DNA-binding transcription factor activity
M481_2592	COG2814	Major facilitator Superfamily
M481_2594	COG2719	SpoVR family
M481_26	COG0473	3-isopropylmalate dehydrogenase activity
M481_260	COG0589	response to stress
M481_2600	COG1104	cysteine desulfurase activity
M481_264	COG0339	signal peptide processing
M481_265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M481_2652	COG0582	viral genome integration into host DNA
M481_2654	COG0179	Fumarylacetoacetate (FAA) hydrolase
M481_2655	COG2951	lytic endotransglycosylase activity
M481_2658	COG2894	cell division
M481_2659	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M481_266	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M481_2660	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M481_2661	COG0318	PFAM AMP-dependent synthetase and ligase
M481_2662	COG3065	identical protein binding
M481_2664	COG1199	ATP-dependent helicase activity
M481_2665	COG0251	oxidation-reduction process
M481_2668	COG0800	Aldolase
M481_267	COG3835	regulator
M481_2670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M481_2671	COG1737	Transcriptional regulator
M481_2672	COG0469	pyruvate kinase activity
M481_2673	COG1560	Kdo2-lipid A biosynthetic process
M481_2674	COG0739	heme binding
M481_2675	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M481_2677	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M481_268	COG2610	gluconate transmembrane transporter activity
M481_2682	COG0494	nUDIX hydrolase
M481_2684	COG1801	Protein of unknown function DUF72
M481_2685	COG3788	relative of glutathione S-transferase, MAPEG superfamily
M481_2689	COG3102	Protein conserved in bacteria
M481_269	COG1929	Belongs to the glycerate kinase type-1 family
M481_2694	COG0728	peptidoglycan biosynthetic process
M481_2695	COG0673	inositol 2-dehydrogenase activity
M481_2696	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M481_2699	COG3381	protein complex oligomerization
M481_2702	COG1940	carbohydrate kinase activity
M481_2703	COG0584	glycerophosphoryl diester phosphodiesterase
M481_2704	COG3842	ATPase activity
M481_2707	COG1176	ABC-type spermidine putrescine transport system, permease component I
M481_2708	COG3833	ABC-type maltose transport systems, permease component
M481_2712	COG0659	secondary active sulfate transmembrane transporter activity
M481_2714	COG2912	Transglutaminase-like superfamily
M481_2715	COG3094	Invasion gene expression up-regulator, SirB
M481_2716	COG2890	protein-(glutamine-N5) methyltransferase activity
M481_2721	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M481_2724	COG0012	GTP binding
M481_2734	COG0745	RESPONSE REGULATOR receiver
M481_274	COG1295	ribonuclease BN
M481_2740	COG5002	protein histidine kinase activity
M481_2749	COG0500	methyltransferase
M481_275	COG2134	cdp-diacylglycerol pyrophosphatase
M481_2754	COG3328	transposase activity
M481_276	COG2982	Protein involved in outer membrane biogenesis
M481_2763	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M481_2764	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M481_2765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M481_2768	COG0402	S-adenosylhomocysteine deaminase activity
M481_277	COG2200	EAL domain
M481_2775	COG3328	transposase activity
M481_278	COG1942	4-Oxalocrotonate Tautomerase
M481_2784	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M481_2785	COG3850	Histidine kinase
M481_2787	COG0387	Pfam Sodium calcium exchanger
M481_2788	COG1702	phosphate starvation-inducible protein PhoH
M481_279	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M481_2791	COG3658	cytochrome
M481_2792	COG1215	transferase activity, transferring glycosyl groups
M481_2793	COG0726	polysaccharide deacetylase
M481_2793	COG1649	PFAM Uncharacterised BCR, COG1649
M481_2794	COG0457	Tetratricopeptide repeat
M481_2795	COG0006	proline dipeptidase activity
M481_2799	COG0577	efflux transmembrane transporter activity
M481_2799	COG1136	(ABC) transporter
M481_280	COG0612	Peptidase, M16
M481_2801	COG1136	(ABC) transporter
M481_2801	COG0577	efflux transmembrane transporter activity
M481_2804	COG0672	)-iron permease
M481_2807	COG2066	Belongs to the glutaminase family
M481_2808	COG1349	DNA-binding transcription factor activity
M481_2810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M481_2811	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M481_2819	COG2030	dehydratase
M481_2820	COG0427	acetyl-CoA hydrolase
M481_2823	COG2205	protein histidine kinase activity
M481_2823	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M481_2826	COG3188	usher protein
M481_2828	COG3121	Chaperone
M481_2829	COG3328	transposase activity
M481_2832	COG0582	viral genome integration into host DNA
M481_2833	COG1169	isochorismate synthase
M481_2834	COG2814	Major facilitator Superfamily
M481_2835	COG1132	(ABC) transporter
M481_2838	COG2226	methyltransferase
M481_2838	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M481_2838	COG3433	isochorismatase activity
M481_2842	COG1021	2,3-dihydroxybenzoate-AMP ligase
M481_2843	COG4771	TonB-dependent receptor
M481_2856	COG0395	ABC-type sugar transport system, permease component
M481_2857	COG1175	transmembrane transport
M481_2859	COG0673	inositol 2-dehydrogenase activity
M481_286	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M481_2866	COG3328	transposase activity
M481_2867	COG3328	transposase activity
M481_287	COG2200	EAL domain
M481_287	COG2199	diguanylate cyclase activity
M481_288	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M481_289	COG4608	Belongs to the ABC transporter superfamily
M481_2890	COG2197	response regulator
M481_2892	COG3136	membrane protein required for alginate biosynthesis
M481_2896	COG1113	amino acid transport
M481_2899	COG2837	iron assimilation
M481_29	COG2814	Major facilitator Superfamily
M481_290	COG0444	Belongs to the ABC transporter superfamily
M481_2904	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M481_2904	COG0506	proline dehydrogenase activity
M481_2904	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M481_291	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M481_2911	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M481_2913	COG1191	sigma factor activity
M481_2919	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M481_292	COG0601	transmembrane transport
M481_2920	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M481_2923	COG1677	Flagellar hook-basal body complex protein FliE
M481_2925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M481_2927	COG1157	protein secretion by the type III secretion system
M481_2928	COG2882	bacterial-type flagellum organization
M481_293	COG0747	negative chemotaxis
M481_2930	COG1580	Controls the rotational direction of flagella during chemotaxis
M481_2935	COG1987	bacterial-type flagellum assembly
M481_2939	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M481_2940	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_2941	COG1129	ABC transporter
M481_2943	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_2944	COG3347	Dehydrogenase
M481_2944	COG1028	Short-chain dehydrogenase reductase Sdr
M481_2945	COG2390	Transcriptional regulator
M481_2947	COG1256	bacterial-type flagellum assembly
M481_295	COG2831	hemolysin activation secretion protein
M481_2951	COG4786	Flagellar basal body rod
M481_2953	COG1749	Flagellar hook protein flgE
M481_2954	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M481_2955	COG1558	bacterial-type flagellum-dependent cell motility
M481_2956	COG1815	bacterial-type flagellum-dependent cell motility
M481_2958	COG2747	anti-sigma28 factor FlgM
M481_2959	COG3418	PFAM FlgN family protein
M481_2964	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M481_2965	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M481_2970	COG2372	response to copper ion
M481_2971	COG1528	Iron-storage protein
M481_2974	COG1770	oligopeptidase
M481_2977	COG3141	response to X-ray
M481_2978	COG0513	Belongs to the DEAD box helicase family
M481_2983	COG1760	l-serine dehydratase
M481_2984	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M481_2985	COG2368	4-hydroxyphenylacetate
M481_2988	COG3971	2-oxopent-4-enoate hydratase activity
M481_299	COG2271	Major facilitator Superfamily
M481_2990	COG3384	dioxygenase
M481_2991	COG1012	belongs to the aldehyde dehydrogenase family
M481_2994	COG1846	Transcriptional regulator
M481_2995	COG1253	flavin adenine dinucleotide binding
M481_2996	COG1253	flavin adenine dinucleotide binding
M481_2997	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M481_2997	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M481_2998	COG3715	PTS system
M481_2999	COG3716	PTS system mannose fructose sorbose family IID component
M481_300	COG3851	Histidine kinase
M481_3003	COG3447	MASE1 domain protein
M481_3003	COG5001	Diguanylate cyclase
M481_3003	COG5002	protein histidine kinase activity
M481_3005	COG2226	methyltransferase
M481_3007	COG1278	Cold shock
M481_301	COG2197	response regulator
M481_3010	COG1113	amino acid transport
M481_3017	COG2207	Transcriptional regulator
M481_3019	COG1132	(ABC) transporter
M481_302	COG2194	sulfuric ester hydrolase activity
M481_3020	COG1943	Transposase
M481_3026	COG2223	nitrite transmembrane transporter activity
M481_3031	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M481_3036	COG3122	Protein conserved in bacteria
M481_3040	COG0534	Mate efflux family protein
M481_3044	COG4948	Mandelate Racemase Muconate Lactonizing
M481_3046	COG1028	Short-chain dehydrogenase reductase Sdr
M481_3047	COG3011	Protein conserved in bacteria
M481_3048	COG2271	Major facilitator Superfamily
M481_3049	COG3328	transposase activity
M481_3050	COG1388	LysM domain
M481_3050	COG1470	cell adhesion involved in biofilm formation
M481_3051	COG3328	transposase activity
M481_3054	COG2925	Exonuclease
M481_3055	COG0531	amino acid
M481_3057	COG0371	Dehydrogenase
M481_3058	COG1129	ABC transporter
M481_3059	COG1129	ABC transporter
M481_3060	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_3062	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M481_3064	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M481_3066	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M481_3066	COG0131	Imidazoleglycerol-phosphate dehydratase
M481_3067	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M481_3070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M481_3070	COG0140	phosphoribosyl-ATP diphosphatase activity
M481_3072	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M481_3073	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M481_3076	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M481_3077	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M481_3078	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M481_3079	COG1120	ATPase activity
M481_308	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M481_3082	COG3486	L-lysine 6-monooxygenase (NADPH) activity
M481_3083	COG0076	glutamate decarboxylase activity
M481_3084	COG4114	ferric iron reductase
M481_3085	COG1253	flavin adenine dinucleotide binding
M481_3086	COG2982	Protein involved in outer membrane biogenesis
M481_3089	COG0489	protein tyrosine kinase activity
M481_3091	COG1943	Transposase
M481_3095	COG2814	Major facilitator Superfamily
M481_3097	COG1346	cytolysis
M481_3100	COG2949	membrane
M481_3104	COG4211	Belongs to the binding-protein-dependent transport system permease family
M481_3107	COG2311	Membrane
M481_3109	COG0477	Major facilitator Superfamily
M481_3110	COG0583	DNA-binding transcription factor activity
M481_3116	COG1136	(ABC) transporter
M481_3118	COG0303	'Molybdopterin
M481_3121	COG0488	(ABC) transporter
M481_313	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
M481_314	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M481_3148	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M481_3149	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M481_315	COG1739	Uncharacterized protein family UPF0029
M481_3151	COG1028	Short-chain dehydrogenase reductase Sdr
M481_3152	COG1024	Enoyl-CoA hydratase
M481_3154	COG3425	synthase
M481_3155	COG1028	Short-chain dehydrogenase reductase Sdr
M481_3156	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M481_3157	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M481_3159	COG1028	Short-chain dehydrogenase reductase Sdr
M481_3166	COG2920	part of a sulfur-relay system
M481_3170	COG1832	CoA-binding protein
M481_3171	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M481_3173	COG0210	DNA helicase
M481_3174	COG3304	Inner membrane component domain
M481_3175	COG1289	transmembrane transporter activity
M481_3176	COG3070	regulator of competence-specific genes
M481_3178	COG2885	chlorophyll binding
M481_3178	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M481_3179	COG1943	Transposase
M481_3181	COG1067	ATP-dependent peptidase activity
M481_3184	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M481_3188	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M481_3189	COG1943	Transposase
M481_3191	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M481_3195	COG0681	Belongs to the peptidase S26 family
M481_3198	COG3086	response to oxidative stress
M481_3199	COG3026	antisigma factor binding
M481_32	COG4143	(ABC) transporter
M481_3200	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
M481_3202	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M481_3204	COG0513	Belongs to the DEAD box helicase family
M481_3215	COG1984	allophanate hydrolase subunit 2
M481_3216	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M481_3218	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M481_3219	COG5212	phosphodiesterase
M481_3221	COG3272	Protein of unknown function (DUF1722)
M481_3226	COG2205	protein histidine kinase activity
M481_3227	COG2205	protein histidine kinase activity
M481_3228	COG0745	RESPONSE REGULATOR receiver
M481_3232	COG0033	Phosphoglucomutase
M481_3233	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M481_3237	COG1917	Cupin 2, conserved barrel domain protein
M481_3237	COG2169	Transcriptional regulator
M481_3238	COG1447	Phosphotransferase system cellobiose-specific component IIA
M481_3239	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M481_324	COG0805	protein transport
M481_3240	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M481_3241	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M481_3242	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M481_3243	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M481_3245	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M481_3246	COG4413	Urea transporter
M481_3248	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M481_3255	COG1124	(ABC) transporter
M481_3256	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M481_3257	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M481_3259	COG0747	negative chemotaxis
M481_326	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M481_3260	COG1278	Cold shock
M481_3268	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M481_3269	COG4175	Glycine betaine
M481_3270	COG4176	ABC-type proline glycine betaine transport system permease component
M481_3271	COG2113	Glycine betaine
M481_3273	COG1953	Uracil, thiamine, allantoin
M481_3275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M481_3277	COG2226	methyltransferase
M481_3279	COG0741	lytic transglycosylase activity
M481_3279	COG1388	LysM domain
M481_3282	COG0656	L-ascorbic acid biosynthetic process
M481_3288	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M481_3290	COG2011	ABC-type metal ion transport system permease component
M481_3291	COG1464	Belongs to the NlpA lipoprotein family
M481_3293	COG1720	tRNA m6t6A37 methyltransferase activity
M481_3295	COG3015	lipoprotein NlpE involved in copper resistance
M481_3297	COG4681	YaeQ
M481_3299	COG4568	rho-dependent transcription termination
M481_33	COG1178	ABC-type Fe3 transport system permease component
M481_330	COG1322	Protein conserved in bacteria
M481_3301	COG0037	tRNA processing
M481_3302	COG0346	lactoylglutathione lyase activity
M481_3304	COG0587	DNA-directed DNA polymerase activity
M481_3306	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M481_331	COG0586	Pfam SNARE associated Golgi protein
M481_3310	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M481_3312	COG0750	zinc metalloprotease
M481_3313	COG0575	Belongs to the CDS family
M481_3314	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M481_332	COG1966	Carbon starvation protein
M481_3320	COG0024	Methionine aminopeptidase
M481_3325	COG0564	pseudouridine synthase activity
M481_3326	COG3098	single-species biofilm formation
M481_3327	COG1943	Transposase
M481_3330	COG1611	Belongs to the LOG family
M481_3331	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M481_3333	COG2363	Small membrane protein
M481_3334	COG0583	DNA-binding transcription factor activity
M481_3336	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M481_3337	COG2166	iron-sulfur cluster assembly
M481_3338	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M481_3339	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M481_334	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M481_3343	COG0860	N-Acetylmuramoyl-L-alanine amidase
M481_3344	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M481_3344	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M481_3349	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M481_335	COG0412	Dienelactone hydrolase
M481_3350	COG1074	ATP-dependent DNA helicase activity
M481_3352	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M481_3363	COG0667	Aldo Keto reductase
M481_3369	COG0019	diaminopimelate decarboxylase activity
M481_3370	COG1609	Transcriptional regulator
M481_3371	COG2814	Major facilitator Superfamily
M481_3372	COG0583	DNA-binding transcription factor activity
M481_3373	COG0583	DNA-binding transcription factor activity
M481_3375	COG0840	transmembrane signaling receptor activity
M481_3378	COG3328	transposase activity
M481_338	COG0583	DNA-binding transcription factor activity
M481_339	COG0679	Auxin Efflux Carrier
M481_3395	COG0288	reversible hydration of carbon dioxide
M481_340	COG0584	glycerophosphoryl diester phosphodiesterase
M481_3403	COG3119	arylsulfatase activity
M481_3404	COG1349	DNA-binding transcription factor activity
M481_3406	COG2222	sugar isomerase
M481_3407	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M481_3408	COG3715	PTS system
M481_3409	COG3716	PTS system mannose fructose sorbose family IID component
M481_3410	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M481_3412	COG1028	Short-chain dehydrogenase reductase Sdr
M481_3414	COG0641	radical SAM
M481_3415	COG3119	arylsulfatase activity
M481_3417	COG0191	fructose-bisphosphate aldolase activity
M481_3421	COG2271	Major facilitator Superfamily
M481_3425	COG1263	PTS System
M481_3425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M481_3426	COG1874	Beta-galactosidase
M481_3427	COG1874	Beta-galactosidase
M481_3428	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M481_3429	COG3833	ABC-type maltose transport systems, permease component
M481_3430	COG1175	transmembrane transport
M481_3431	COG2182	Extracellular solute-binding protein
M481_3433	COG1129	ABC transporter
M481_3434	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_3435	COG1879	ABC-type sugar transport system periplasmic component
M481_3437	COG0791	NLP P60 protein
M481_3438	COG1695	Transcriptional regulator
M481_3455	COG2944	sequence-specific DNA binding
M481_3460	COG0582	viral genome integration into host DNA
M481_3464	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M481_3465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M481_3466	COG4974	Belongs to the 'phage' integrase family
M481_3467	COG0716	FMN binding
M481_3468	COG4452	Inner membrane protein CreD
M481_3469	COG2205	protein histidine kinase activity
M481_3470	COG0745	RESPONSE REGULATOR receiver
M481_3471	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M481_3474	COG1272	protein, Hemolysin III
M481_3476	COG5295	Hep Hag repeat protein
M481_3482	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M481_3483	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M481_3484	COG0006	proline dipeptidase activity
M481_3487	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M481_3488	COG1943	Transposase
M481_3489	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M481_3490	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M481_3495	COG0191	fructose-bisphosphate aldolase activity
M481_3499	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M481_35	COG0586	Pfam SNARE associated Golgi protein
M481_3500	COG0501	Belongs to the peptidase M48B family
M481_3502	COG1166	arginine decarboxylase activity
M481_3506	COG2356	endonuclease I
M481_3507	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M481_3508	COG0189	ligase activity
M481_3511	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M481_3513	COG2805	Type II/IV secretion system protein
M481_3514	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M481_3515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M481_3516	COG0762	integral membrane protein
M481_3518	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M481_3519	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M481_352	COG0410	ABC transporter
M481_3520	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M481_3520	COG3064	Membrane
M481_3520	COG1073	alpha beta
M481_3523	COG2066	Belongs to the glutaminase family
M481_3524	COG3171	Protein conserved in bacteria
M481_3526	COG1194	a g-specific adenine glycosylase
M481_353	COG0411	ABC transporter
M481_3530	COG4774	siderophore transport
M481_3531	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_3532	COG1129	ABC transporter
M481_3533	COG1879	ABC-type sugar transport system periplasmic component
M481_3534	COG1982	Orn Lys Arg decarboxylase major
M481_3538	COG1662	PFAM IS1 transposase
M481_354	COG4177	L-phenylalanine transmembrane transporter activity
M481_355	COG0559	Belongs to the binding-protein-dependent transport system permease family
M481_3556	COG2771	luxR family
M481_3557	COG3916	Acyl-homoserine-lactone synthase
M481_356	COG0683	leucine binding
M481_3567	COG2211	Major facilitator Superfamily
M481_3568	COG2801	Transposase and inactivated derivatives
M481_3570	COG3133	Outer membrane lipoprotein
M481_3575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M481_3576	COG1191	sigma factor activity
M481_358	COG1943	Transposase
M481_3581	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M481_3583	COG3328	transposase activity
M481_3584	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M481_3587	COG3710	Transcriptional regulator
M481_3591	COG1256	bacterial-type flagellum assembly
M481_3593	COG1706	bacterial-type flagellum-dependent cell motility
M481_3594	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M481_3595	COG4786	Flagellar basal body rod
M481_3596	COG4787	bacterial-type flagellum-dependent cell motility
M481_3597	COG1749	Flagellar hook protein flgE
M481_3598	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M481_3599	COG1558	bacterial-type flagellum-dependent cell motility
M481_36	COG0417	DNA replication proofreading
M481_360	COG2177	Part of the ABC transporter FtsEX involved in
M481_3600	COG1815	bacterial-type flagellum-dependent cell motility
M481_3601	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
M481_361	COG2884	Cell division ATP-binding protein ftsE
M481_3610	COG2204	response regulator
M481_3614	COG1987	bacterial-type flagellum assembly
M481_3615	COG1684	flagellar biosynthetic protein fliR
M481_3616	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M481_362	COG0552	protein localization to endoplasmic reticulum
M481_362	COG0552	protein localization to endoplasmic reticulum
M481_3620	COG4592	Periplasmic binding protein
M481_3628	COG4964	Belongs to the GSP D family
M481_3629	COG4964	Belongs to the GSP D family
M481_363	COG0742	ribosomal rna small subunit methyltransferase
M481_3639	COG0848	biopolymer transport protein
M481_364	COG3776	membrane
M481_3641	COG0811	peptide transport
M481_3642	COG0626	cystathionine gamma-synthase activity
M481_3643	COG0586	Pfam SNARE associated Golgi protein
M481_3644	COG2207	Transcriptional regulator
M481_3645	COG1979	alcohol dehydrogenase
M481_3646	COG0656	L-ascorbic acid biosynthetic process
M481_3649	COG2132	Multicopper oxidase
M481_3650	COG0204	Acyl-transferase
M481_3651	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M481_3652	COG2249	NAD(P)H dehydrogenase (quinone) activity
M481_3653	COG0583	DNA-binding transcription factor activity
M481_3654	COG0187	DNA topoisomerase II activity
M481_3655	COG3150	esterase
M481_3656	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M481_3657	COG3151	Protein conserved in bacteria
M481_3658	COG0494	nUDIX hydrolase
M481_3659	COG1538	Outer membrane efflux protein
M481_3662	COG0754	glutathionylspermidine amidase activity
M481_3663	COG3384	dioxygenase
M481_3667	COG0531	amino acid
M481_367	COG3714	YhhN family
M481_3670	COG3025	triphosphatase activity
M481_3671	COG4991	sh3 domain protein
M481_3674	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M481_3678	COG0358	DNA primase activity
M481_3679	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M481_3696	COG0251	oxidation-reduction process
M481_370	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M481_3704	COG1289	transmembrane transporter activity
M481_3708	COG0395	ABC-type sugar transport system, permease component
M481_3710	COG1653	transport
M481_3711	COG1609	Transcriptional regulator
M481_3712	COG3459	Glycosyltransferase 36 associated
M481_3713	COG3842	ATPase activity
M481_3717	COG3210	domain, Protein
M481_3719	COG3210	domain, Protein
M481_372	COG0247	lactate metabolic process
M481_3721	COG3210	domain, Protein
M481_3722	COG2831	hemolysin activation secretion protein
M481_3723	COG4245	von Willebrand factor, type A
M481_3730	COG3247	response to pH
M481_3731	COG1902	pentaerythritol trinitrate reductase activity
M481_3731	COG0446	pyridine nucleotide-disulphide oxidoreductase
M481_3734	COG1451	nucleotide metabolic process
M481_3735	COG0673	inositol 2-dehydrogenase activity
M481_3738	COG1943	Transposase
M481_374	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M481_3740	COG2721	sulfolactate sulfo-lyase activity
M481_3741	COG0246	Mannitol dehydrogenase
M481_3743	COG2271	Major facilitator Superfamily
M481_3744	COG2271	Major facilitator Superfamily
M481_3747	COG0586	Pfam SNARE associated Golgi protein
M481_375	COG0584	glycerophosphoryl diester phosphodiesterase
M481_3750	COG4575	ribosome binding
M481_3751	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
M481_3753	COG2259	Doxx family
M481_3754	COG0435	Glutathione S-transferase
M481_3755	COG0583	DNA-binding transcription factor activity
M481_3756	COG1741	Belongs to the pirin family
M481_3757	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M481_3761	COG2823	Periplasmic or secreted lipoprotein
M481_3763	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M481_3764	COG0784	Response regulator, receiver
M481_3764	COG2198	Histidine kinase
M481_3764	COG5002	protein histidine kinase activity
M481_3765	COG1242	4 iron, 4 sulfur cluster binding
M481_3766	COG0070	glutamate synthase
M481_3766	COG0069	glutamate synthase activity
M481_3766	COG0067	glutamate synthase
M481_3767	COG0493	'glutamate synthase
M481_3769	COG2969	positive regulation of protein catabolic process
M481_377	COG0561	phosphatase activity
M481_3770	COG0625	glutathione transferase activity
M481_3773	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M481_3774	COG3105	Protein conserved in bacteria
M481_3775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M481_3776	COG1943	Transposase
M481_3777	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M481_3779	COG5007	Belongs to the BolA IbaG family
M481_378	COG2267	carboxylic ester hydrolase activity
M481_3780	COG3113	response to antibiotic
M481_3781	COG2854	intermembrane phospholipid transfer
M481_3782	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M481_3783	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M481_3784	COG1127	ABC transporter
M481_3785	COG0530	calcium, potassium:sodium antiporter activity
M481_3786	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M481_3786	COG0517	IMP dehydrogenase activity
M481_3787	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M481_3788	COG3117	lipopolysaccharide transmembrane transporter activity
M481_3789	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M481_379	COG1280	lysine exporter protein (LysE YggA)
M481_3790	COG1137	ATPase activity
M481_3791	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M481_3793	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M481_3795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M481_380	COG1280	lysine exporter protein (LysE YggA)
M481_3800	COG1609	Transcriptional regulator
M481_3801	COG1263	PTS System
M481_3801	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M481_3802	COG0366	Alpha amylase catalytic
M481_3803	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M481_3804	COG3783	Cytochrome b(562)
M481_3806	COG0312	modulator of DNA gyrase
M481_3808	COG2732	(Barnase) inhibitor
M481_381	COG0514	ATP-dependent DNA helicase (RecQ)
M481_3811	COG1012	belongs to the aldehyde dehydrogenase family
M481_3815	COG0583	DNA-binding transcription factor activity
M481_382	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
M481_3825	COG0312	modulator of DNA gyrase
M481_3826	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M481_3827	COG3164	Protein of unknown function
M481_3828	COG1530	ribonuclease E activity
M481_383	COG2050	protein possibly involved in aromatic compounds catabolism
M481_3830	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M481_3831	COG1792	Involved in formation and maintenance of cell shape
M481_3832	COG1077	Cell shape determining protein MreB Mrl
M481_3833	COG2199	diguanylate cyclase activity
M481_3833	COG2200	EAL domain
M481_3834	COG0604	alcohol dehydrogenase
M481_3835	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M481_3838	COG0511	ligase activity, forming carbon-carbon bonds
M481_3839	COG0439	Biotin carboxylase
M481_3841	COG3924	membrane
M481_3842	COG4145	pantothenate transmembrane transporter activity
M481_3844	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M481_3845	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M481_3849	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M481_385	COG0598	Magnesium transport protein CorA
M481_3851	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M481_3852	COG3133	Outer membrane lipoprotein
M481_3853	COG1278	Cold shock
M481_3854	COG1278	Cold shock
M481_3855	COG1943	Transposase
M481_3858	COG0625	glutathione transferase activity
M481_386	COG5564	TIM-barrel signal transduction protein
M481_3860	COG1069	ribulokinase activity
M481_3862	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_3863	COG1129	ABC transporter
M481_3865	COG1560	Kdo2-lipid A biosynthetic process
M481_3867	COG0025	NhaP-type Na H and K H
M481_3868	COG2252	PERMEase
M481_3869	COG3077	Addiction module antitoxin, RelB DinJ family
M481_387	COG5441	Belongs to the UPF0261 family
M481_3871	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M481_3873	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M481_3874	COG0431	NADPH-dependent FMN reductase
M481_3876	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M481_3877	COG1869	D-ribose catabolic process
M481_3878	COG2207	Transcriptional regulator
M481_3878	COG1917	Cupin 2, conserved barrel domain protein
M481_3879	COG0673	inositol 2-dehydrogenase activity
M481_3882	COG3209	COG3209 Rhs family protein
M481_3884	COG3501	Rhs element vgr protein
M481_3890	COG3209	COG3209 Rhs family protein
M481_3893	COG3501	Rhs element vgr protein
M481_390	COG0210	DNA helicase
M481_3909	COG2801	Transposase and inactivated derivatives
M481_391	COG1011	Hydrolase
M481_392	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M481_3920	COG1175	transmembrane transport
M481_3921	COG3833	ABC-type maltose transport systems, permease component
M481_3924	COG0527	aspartate kinase activity
M481_3929	COG1414	Transcriptional regulator
M481_393	COG3159	Protein conserved in bacteria
M481_3931	COG2224	Isocitrate lyase
M481_3932	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M481_3943	COG0542	response to heat
M481_3945	COG0564	pseudouridine synthase activity
M481_3946	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M481_3947	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M481_3949	COG0077	Prephenate dehydratase
M481_3949	COG1605	Chorismate mutase
M481_395	COG5567	small periplasmic lipoprotein
M481_3950	COG1605	Chorismate mutase
M481_3950	COG0287	Prephenate dehydrogenase
M481_3951	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M481_3957	COG0237	dephospho-CoA kinase activity
M481_3959	COG1459	type II secretion system
M481_3960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M481_3961	COG4969	Belongs to the N-Me-Phe pilin family
M481_3963	COG3023	N-Acetylmuramoyl-L-alanine amidase
M481_3964	COG3725	Membrane protein required for beta-lactamase induction
M481_3965	COG1113	amino acid transport
M481_3966	COG2186	Transcriptional regulator
M481_3967	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M481_3968	COG0508	dehydrogenase complex catalyzes the overall conversion of
M481_3969	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M481_397	COG3072	Adenylate cyclase
M481_3970	COG1943	Transposase
M481_3971	COG1049	propionate catabolic process, 2-methylcitrate cycle
M481_3973	COG0697	spore germination
M481_3977	COG2132	Multicopper oxidase
M481_3978	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M481_3979	COG0288	reversible hydration of carbon dioxide
M481_3980	COG1131	(ABC) transporter
M481_3981	COG0842	Transport permease protein
M481_3983	COG0726	polysaccharide deacetylase
M481_3987	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M481_3988	COG0617	tRNA 3'-terminal CCA addition
M481_3989	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M481_399	COG1587	Uroporphyrinogen-III synthase
M481_3990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M481_3992	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M481_3993	COG1643	Atp-dependent helicase
M481_3994	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M481_3995	COG1120	ATPase activity
M481_3996	COG1120	ATPase activity
M481_3997	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M481_3998	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M481_40	COG2885	chlorophyll binding
M481_40	COG3047	cAMP biosynthetic process
M481_400	COG2959	enzyme of heme biosynthesis
M481_4002	COG2860	membrane
M481_4004	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M481_4006	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M481_4007	COG3437	response regulator, receiver
M481_4007	COG3850	Histidine kinase
M481_4007	COG2205	protein histidine kinase activity
M481_4007	COG4999	Histidine kinase
M481_4008	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M481_4009	COG3956	TIGRFAM MazG family protein
M481_401	COG3071	HemY protein
M481_4013	COG0602	queuosine metabolic process
M481_4014	COG0720	synthase
M481_4025	COG0529	Catalyzes the synthesis of activated sulfate
M481_4028	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M481_4033	COG1388	LysM domain
M481_4033	COG4942	peptidase
M481_4034	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M481_4035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M481_4036	COG0698	ribose 5-phosphate isomerase
M481_4037	COG1063	alcohol dehydrogenase
M481_4038	COG1028	Short-chain dehydrogenase reductase Sdr
M481_4039	COG2376	Dihydroxyacetone kinase
M481_4042	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M481_4046	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M481_4047	COG1858	cytochrome C peroxidase
M481_4049	COG4771	TonB-dependent receptor
M481_4051	COG0024	Methionine aminopeptidase
M481_4053	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M481_4053	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M481_4054	COG1070	Carbohydrate kinase
M481_4055	COG3623	hexulose-6-phosphate isomerase
M481_4056	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_4057	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_4058	COG1129	ABC transporter
M481_4060	COG1349	DNA-binding transcription factor activity
M481_4061	COG0235	Class ii aldolase
M481_4062	COG0243	molybdopterin cofactor binding
M481_4063	COG0437	4 iron, 4 sulfur cluster binding
M481_4064	COG3302	dmso reductase anchor subunit
M481_4065	COG3381	protein complex oligomerization
M481_4066	COG3038	cytochrome b561
M481_4067	COG3783	Cytochrome b(562)
M481_4071	COG1129	ABC transporter
M481_4072	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_4073	COG3959	Transketolase, thiamine diphosphate binding domain
M481_4074	COG3958	Transketolase
M481_4075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M481_408	COG1113	amino acid transport
M481_4082	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M481_4083	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M481_4087	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M481_4088	COG1238	metal cluster binding
M481_4089	COG2918	glutathione biosynthetic process
M481_4091	COG4536	flavin adenine dinucleotide binding
M481_4092	COG4137	Cytochrome C assembly protein
M481_4093	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M481_4098	COG3137	Salt-induced outer membrane protein
M481_4099	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M481_4100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M481_4101	COG3279	Response regulator of the LytR AlgR family
M481_4102	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M481_4105	COG0494	nUDIX hydrolase
M481_4110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M481_4118	COG3328	transposase activity
M481_412	COG2244	polysaccharide biosynthetic process
M481_413	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M481_414	COG0456	acetyltransferase
M481_4142	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M481_4144	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M481_415	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M481_4154	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M481_416	COG1088	dTDP-glucose 4,6-dehydratase activity
M481_4160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M481_4161	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M481_4163	COG1943	Transposase
M481_417	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M481_4173	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M481_4174	COG1475	DNA binding
M481_4175	COG1475	DNA binding
M481_418	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M481_419	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M481_4193	COG3941	tape measure
M481_420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M481_4200	COG5301	cellulose 1,4-beta-cellobiosidase activity
M481_4200	COG5301	cellulose 1,4-beta-cellobiosidase activity
M481_4201	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M481_4204	COG1475	DNA binding
M481_421	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M481_422	COG3118	belongs to the thioredoxin family
M481_4220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M481_4227	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M481_4227	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M481_4232	COG3328	transposase activity
M481_4249	COG2801	Transposase and inactivated derivatives
M481_4253	COG2801	Transposase and inactivated derivatives
M481_4258	COG2801	Transposase and inactivated derivatives
M481_426	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M481_4274	COG0515	serine threonine protein kinase
M481_4276	COG2801	Transposase and inactivated derivatives
M481_4281	COG2801	Transposase and inactivated derivatives
M481_4282	COG2963	transposase activity
M481_4283	COG5599	Phosphatase
M481_4284	COG1317	bacterial-type flagellum organization
M481_4286	COG4669	(LipO)protein
M481_429	COG3121	Chaperone
M481_4295	COG2207	Transcriptional regulator
M481_4297	COG4792	protein secretion
M481_4298	COG4791	protein targeting
M481_4299	COG4794	Type iii secretion
M481_4300	COG4790	Type iii secretion
M481_4301	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M481_4310	COG4789	Type iii secretion
M481_4314	COG0457	Tetratricopeptide repeat
M481_4317	COG3328	transposase activity
M481_4318	COG3328	transposase activity
M481_432	COG3121	Chaperone
M481_4320	COG4886	Leucine-rich repeat (LRR) protein
M481_4325	COG3177	Filamentation induced by cAMP protein fic
M481_4329	COG2801	Transposase and inactivated derivatives
M481_4331	COG1192	Involved in chromosome partitioning
M481_4332	COG1475	DNA binding
M481_4334	COG3609	addiction module antidote protein, CC2985 family
M481_4336	COG5599	Phosphatase
M481_439	COG0583	DNA-binding transcription factor activity
M481_447	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M481_448	COG3978	acetolactate synthase activity
M481_451	COG3085	chromosome segregation
M481_452	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_454	COG1172	Belongs to the binding-protein-dependent transport system permease family
M481_455	COG1129	ABC transporter
M481_456	COG1879	ABC-type sugar transport system periplasmic component
M481_465	COG0151	Belongs to the GarS family
M481_468	COG3068	Protein conserved in bacteria
M481_469	COG1515	deoxyribonuclease V activity
M481_47	COG3501	Rhs element vgr protein
M481_474	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M481_476	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M481_481	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M481_489	COG0250	Participates in transcription elongation, termination and antitermination
M481_490	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M481_501	COG2986	histidine ammonia-lyase
M481_504	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M481_507	COG4607	ABC-type enterochelin transport system periplasmic component
M481_509	COG4605	iron ion homeostasis
M481_511	COG4604	ABC transporter, ATP-binding protein
M481_518	COG0582	viral genome integration into host DNA
M481_520	COG1609	Transcriptional regulator
M481_520	COG2207	Transcriptional regulator
M481_521	COG4214	carbohydrate transport
M481_523	COG4213	ABC transporter substrate-binding protein
M481_525	COG1070	Carbohydrate kinase
M481_527	COG3121	Chaperone
M481_528	COG3188	usher protein
M481_529	COG3188	usher protein
M481_531	COG3274	enterobacterial common antigen metabolic process
M481_533	COG2801	Transposase and inactivated derivatives
M481_535	COG0460	homoserine dehydrogenase
M481_535	COG0527	aspartate kinase activity
M481_536	COG0626	cystathionine gamma-synthase activity
M481_538	COG4682	membrane
M481_540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M481_542	COG1609	Transcriptional regulator
M481_543	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M481_546	COG1575	Belongs to the MenA family. Type 1 subfamily
M481_554	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M481_555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M481_556	COG1494	fructose-1,6-bisphosphatase
M481_558	COG3152	Membrane
M481_561	COG0583	DNA-binding transcription factor activity
M481_562	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M481_563	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M481_564	COG0471	metal ion transport
M481_565	COG0471	metal ion transport
M481_567	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M481_57	COG0564	pseudouridine synthase activity
M481_572	COG3678	ATP-independent chaperone mediated protein folding
M481_573	COG0745	RESPONSE REGULATOR receiver
M481_574	COG2205	protein histidine kinase activity
M481_575	COG2169	Transcriptional regulator
M481_575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M481_576	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M481_577	COG1045	serine acetyltransferase
M481_58	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M481_580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M481_581	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M481_583	COG4942	peptidase
M481_584	COG2861	carbohydrate metabolic process
M481_585	COG2861	carbohydrate metabolic process
M481_587	COG0156	8-amino-7-oxononanoate synthase activity
M481_589	COG0859	PFAM glycosyl transferase family 9
M481_590	COG0859	PFAM glycosyl transferase family 9
M481_591	COG1519	Transferase
M481_595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M481_598	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M481_6	COG0772	Belongs to the SEDS family
M481_60	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M481_603	COG1561	YicC-like family, N-terminal region
M481_604	COG2860	membrane
M481_605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M481_608	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M481_609	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M481_61	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M481_610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M481_611	COG0786	glutamate:sodium symporter activity
M481_612	COG2233	PERMEase
M481_613	COG2982	Protein involved in outer membrane biogenesis
M481_614	COG0456	acetyltransferase
M481_618	COG1295	ribonuclease BN
M481_619	COG1011	Hydrolase
M481_621	COG0174	glutamine synthetase
M481_622	COG3852	Histidine kinase
M481_624	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M481_627	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M481_627	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M481_628	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M481_629	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M481_630	COG3084	Protein conserved in bacteria
M481_632	COG1763	Mo-molybdopterin cofactor biosynthetic process
M481_633	COG3328	transposase activity
M481_638	COG2186	Transcriptional regulator
M481_640	COG0477	Major facilitator Superfamily
M481_641	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M481_642	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M481_648	COG1522	sequence-specific DNA binding
M481_649	COG0716	FMN binding
M481_652	COG3312	ion transport
M481_66	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M481_662	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M481_663	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M481_664	COG0573	inorganic phosphate transmembrane transporter activity
M481_665	COG0581	inorganic phosphate transmembrane transporter activity
M481_667	COG0704	Plays a role in the regulation of phosphate uptake
M481_669	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M481_670	COG0765	amino acid transport
M481_671	COG0765	amino acid transport
M481_672	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M481_673	COG2252	PERMEase
M481_678	COG0706	membrane insertase activity
M481_68	COG2966	Psort location CytoplasmicMembrane, score
M481_681	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M481_684	COG0592	DNA-directed DNA polymerase activity
M481_685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M481_686	COG0187	DNA topoisomerase II activity
M481_687	COG0561	phosphatase activity
M481_688	COG2801	Transposase and inactivated derivatives
M481_69	COG1280	lysine exporter protein (LysE YggA)
M481_690	COG2423	ornithine cyclodeaminase activity
M481_691	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M481_692	COG0823	Involved in the tonB-independent uptake of proteins
M481_693	COG0823	Involved in the tonB-independent uptake of proteins
M481_694	COG5645	(Lipo)protein
M481_698	COG3977	Valine--pyruvate aminotransferase
M481_70	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M481_700	COG0366	Alpha amylase catalytic
M481_703	COG2885	chlorophyll binding
M481_705	COG2818	Glycosylase
M481_71	COG0505	Belongs to the CarA family
M481_710	COG2213	PTS system mannitol-specific
M481_710	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M481_712	COG3722	fumarate hydratase activity
M481_719	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M481_721	COG0243	molybdopterin cofactor binding
M481_721	COG3383	formate dehydrogenase (NAD+) activity
M481_722	COG3383	formate dehydrogenase (NAD+) activity
M481_722	COG0243	molybdopterin cofactor binding
M481_723	COG0437	4 iron, 4 sulfur cluster binding
M481_724	COG2864	formate dehydrogenase
M481_727	COG3276	selenocysteine insertion sequence binding
M481_729	COG3328	transposase activity
M481_734	COG2801	Transposase and inactivated derivatives
M481_736	COG1349	DNA-binding transcription factor activity
M481_74	COG1047	Peptidyl-prolyl cis-trans
M481_740	COG0058	SHG alpha-glucan phosphorylase activity
M481_741	COG1640	4-alpha-glucanotransferase
M481_748	COG1918	ferrous iron import across plasma membrane
M481_749	COG2183	response to ionizing radiation
M481_750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M481_751	COG0745	RESPONSE REGULATOR receiver
M481_755	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M481_756	COG1011	Hydrolase
M481_759	COG0494	nUDIX hydrolase
M481_760	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M481_765	COG4796	Type ii and iii secretion system protein
M481_77	COG0196	riboflavin kinase activity
M481_770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M481_771	COG0546	phosphoglycolate phosphatase activity
M481_772	COG0180	Tryptophanyl-tRNA synthetase
M481_775	COG2146	nitrite reductase [NAD(P)H] activity
M481_776	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M481_777	COG0402	S-adenosylhomocysteine deaminase activity
M481_781	COG1486	melibiose metabolic process
M481_782	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M481_783	COG0433	COG0433 Predicted ATPase
M481_786	COG1289	transmembrane transporter activity
M481_788	COG1765	OsmC-like protein
M481_79	COG0583	DNA-binding transcription factor activity
M481_790	COG3954	Phosphoribulokinase
M481_792	COG0429	hydrolase of the alpha beta-hydrolase fold
M481_794	COG4521	taurine ABC transporter
M481_796	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M481_797	COG2175	clavaminate synthase activity
M481_800	COG1216	Glycosyl transferase, family 2
M481_801	COG0488	(ABC) transporter
M481_804	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M481_805	COG1047	Peptidyl-prolyl cis-trans
M481_807	COG0545	Peptidyl-prolyl cis-trans isomerase
M481_808	COG2964	Protein conserved in bacteria
M481_813	COG0049	tRNA binding
M481_816	COG1943	Transposase
M481_821	COG0051	transcription antitermination factor activity, RNA binding
M481_826	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M481_828	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M481_829	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M481_83	COG1584	GPR1 FUN34 yaaH family protein
M481_831	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M481_832	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M481_840	COG1841	ribosomal large subunit assembly
M481_842	COG0201	protein transport
M481_843	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M481_846	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M481_849	COG0789	Transcriptional regulator
M481_850	COG3036	rescue of stalled ribosome
M481_852	COG0569	domain protein
M481_856	COG0758	DNA mediated transformation
M481_858	COG0551	DNA topoisomerase type I activity
M481_86	COG0521	Mo-molybdopterin cofactor biosynthetic process
M481_861	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M481_868	COG2801	Transposase and inactivated derivatives
M481_874	COG3162	membrane
M481_876	COG1301	dicarboxylic acid transport
M481_898	COG2391	methyltransferase activity
M481_899	COG0425	Belongs to the sulfur carrier protein TusA family
M481_9	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M481_900	COG0583	DNA-binding transcription factor activity
M481_901	COG0814	amino acid
M481_902	COG0626	cystathionine gamma-synthase activity
M481_904	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M481_905	COG4558	Periplasmic binding protein
M481_906	COG3720	iron ion transport
M481_907	COG4771	TonB-dependent receptor
M481_909	COG0702	epimerase
M481_910	COG3721	Heme iron utilization protein
M481_915	COG1358	cellular component organization or biogenesis
M481_927	COG3121	Chaperone
M481_936	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M481_938	COG0735	belongs to the Fur family
M481_939	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M481_942	COG0305	Participates in initiation and elongation during chromosome replication
M481_943	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M481_944	COG1448	Aminotransferase
M481_945	COG2315	Protein conserved in bacteria
M481_946	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M481_947	COG0629	single-stranded DNA binding
M481_949	COG1454	alcohol dehydrogenase
M481_95	COG0745	RESPONSE REGULATOR receiver
M481_96	COG3045	CreA protein
M481_963	COG1309	transcriptional regulator
M481_964	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M481_964	COG0493	'glutamate synthase
M481_965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M481_966	COG3383	formate dehydrogenase (NAD+) activity
M481_969	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M481_977	COG2076	Multidrug Resistance protein
M481_978	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M481_980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M481_981	COG1053	succinate dehydrogenase
M481_983	COG3264	Mechanosensitive ion channel
M481_983	COG1511	domain protein
M481_986	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M481_989	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M481_99	COG2207	Transcriptional regulator
M481_99	COG3708	Transcriptional regulator
M481_990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M481_990	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M481_991	COG0802	atpase or kinase
M481_992	COG0860	N-Acetylmuramoyl-L-alanine amidase
M481_996	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M481_997	COG0330	HflC and HflK could
M481_998	COG0330	HflC and HflK could
M481_999	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)