locus-tag class description M478_100 ENOG4105XXV Acid-resistance protein M478_1000 ENOG4105VUT cytoplasmic protein M478_1003 ENOG4105DSB aldose 1-epimerase M478_1004 ENOG4105GNX MltA-interacting MipA family protein M478_1005 ENOG4105CYN Serine protein kinase M478_1008 ENOG4105HEI LysR family (Transcriptional regulator M478_1009 ENOG4105EUB pirin domain protein M478_101 ENOG4107SVH Potassium channel protein M478_1010 ENOG4105CNH Multidrug resistance protein MdtL M478_1012 ENOG4105ED1 spovr family M478_1018 ENOG4105C3J Cysteine desulfurase M478_102 ENOG41086WQ Protein CrcB homolog M478_1022 ENOG4105UZW Tail fiber assembly protein M478_103 ENOG41085Q9 Protein CrcB homolog M478_104 ENOG4105VZJ PTS System M478_105 ENOG4105CK1 PTS System M478_106 ENOG4105VCP PTS System M478_1065 ENOG4105HRS Antitermination protein M478_1067 ENOG4105NY2 NinB protein M478_107 ENOG4105EZV Transcriptional regulator M478_1072 ENOG4107R08 Integrase M478_1074 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase M478_1075 ENOG4105CVE Lytic murein transglycosylase M478_1078 ENOG4107QMS site-determining protein M478_1079 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) M478_1080 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) M478_1081 ENOG4105CEY Amp-dependent synthetase and ligase M478_1082 ENOG4105Y4Z Outer Membrane Lipoprotein M478_1083 ENOG41072GX Peptidase M22 Glycoprotease M478_1084 ENOG4105DVT helicase M478_1085 ENOG4105M4H endoribonuclease L-psp M478_1088 ENOG4108UHU Aldolase M478_1090 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase M478_1091 ENOG4106KNT transcriptional regulator M478_1092 ENOG4105CA9 Pyruvate kinase M478_1093 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase M478_1094 ENOG4105DR5 peptidase M478_1095 ENOG4105NXV High-affinity zinc uptake system protein M478_1097 ENOG4105FAV ABC, transporter M478_11 ENOG4108JJ7 ABC transporter M478_1102 ENOG4108TIT dATP pyrophosphohydrolase M478_1104 ENOG41081XQ Conserved Protein M478_1105 ENOG4105WJG Glutathione M478_1109 ENOG4106ZCM YecM protein M478_1113 ENOG4105CJR Integral membrane protein (MviN M478_1114 ENOG4105EP9 oxidoreductase M478_1115 ENOG4105D9U N-acetyltransferase M478_1117 ENOG4105F3T (LipO)protein M478_1118 ENOG4107XHZ cytoplasmic chaperone TorD family protein M478_112 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 M478_1121 ENOG4105E2R ROK family M478_1122 ENOG4108QXE glycerophosphoryl diester phosphodiesterase M478_1123 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) M478_1124 ENOG4108RS6 transposase M478_1126 ENOG4105F38 ABC transporter, permease M478_1127 ENOG4105EG2 ABC transporter, permease M478_1132 ENOG4105CHH sulfate transporter M478_1134 ENOG41063JG Transcriptional regulator M478_1135 ENOG4108YY7 Invasion gene expression up-regulator SirB M478_1136 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) M478_1141 ENOG4105C5T Phosphoribosyl pyrophosphate synthase M478_1142 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria M478_1144 ENOG4105C3G gtp-binding protein M478_1153 ENOG4105ENX hydrolase M478_1155 ENOG4105GR3 Histidine kinase M478_116 ENOG4105EEX Two component transcriptional regulator (Winged helix family M478_1164 ENOG4108WF3 methyltransferase M478_117 ENOG4105C08 Histidine kinase M478_1178 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase M478_1179 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) M478_1180 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) M478_1182 ENOG41090B9 response to stress M478_1183 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) M478_1184 ENOG4105CZE histidine utilization repressor M478_1192 ENOG4108IJ9 (ABC) transporter M478_1193 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component M478_1196 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) M478_1197 ENOG4105FDP GntR family transcriptional regulator M478_121 ENOG4105XIQ Protein of unknown function (DUF2517) M478_1216 ENOG4108WC9 type VI secretion system effector, hcp1 family M478_122 ENOG4107SEY Conserved Protein M478_1227 ENOG4105WH1 Two component transcriptional regulator luxr family M478_1228 ENOG4105XVG cytoplasmic protein M478_1229 ENOG4105RA2 Membrane M478_123 ENOG4105CVP deoxyribo-dipyrimidine photolyase M478_1231 ENOG4108T1M outer membrane protein x M478_1233 ENOG4105C85 amino acid M478_1236 ENOG4105DBE peroxidase M478_1239 ENOG4105CK7 Sodium proline symporter M478_124 ENOG4107RF4 Phosphodiesterase M478_1241 ENOG4105C26 Dehydrogenase M478_1244 ENOG4105CDA abc transporter atp-binding protein M478_1245 ENOG4105E5Q amino acid AbC transporter M478_1246 ENOG4105EAB amino acid AbC transporter M478_1247 ENOG4105K6H D-cysteine desulfhydrase M478_1248 ENOG4108M9K flagella biosynthesis protein FliZ M478_1249 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M478_125 ENOG4107QNR UPF0135 protein M478_1250 ENOG4105I03 Flagellin M478_1251 ENOG4105DTS flagellar hook-associated M478_1252 ENOG4105MQ3 flagellar protein FliS M478_1255 ENOG4108T5G Adenylate M478_1256 ENOG4105DHT Metal Dependent Phosphohydrolase M478_1260 ENOG4105VQ0 flagellar hook-basal body complex protein fliE M478_1261 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) M478_1262 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) M478_1263 ENOG41090PJ Flagellar assembly protein M478_1264 ENOG4108JIR Flagellum-specific ATP synthase M478_1265 ENOG4105GSA Flagellar export protein flij M478_1266 ENOG4105WF4 Flagellar hook-length control protein M478_1267 ENOG4107ZI8 flagellar basal body-associated protein flil M478_1268 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) M478_1269 ENOG4105DD5 Flagellar motor switch protein M478_127 ENOG4105P4J Allophanate hydrolase, subunit 1 M478_1271 ENOG4105CN7 Flagellar biosynthetic protein FliP M478_1272 ENOG4105VS8 Flagellar biosynthetic protein fliq M478_1273 ENOG4105D19 Role in flagellar biosynthesis (By similarity) M478_1276 ENOG4108MGF sugar kinase M478_1277 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane M478_1278 ENOG4105C2J ABC transporter M478_128 ENOG4107R7A Allophanate hydrolase subunit 2 M478_1280 ENOG4105CNN ABC, transporter M478_1282 ENOG4105DKT Transcriptional regulator M478_1283 ENOG4105DTJ flagellar hook-associated protein M478_1284 ENOG4105E1Q flagellar hook-associated protein M478_1285 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj M478_1288 ENOG4105CGA flagellar basal-body rod protein FlgG M478_1289 ENOG4108KPB Flagellar basal-body rod protein FlgF M478_1290 ENOG4105BZE flagellar hook protein, FlgE M478_1291 ENOG4105W00 Flagellar hook capping protein M478_1292 ENOG4108ZC9 flagellar basal-body rod protein flgc M478_1293 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) M478_1294 ENOG4105CKS Flagella basal body P-ring formation protein flgA M478_1295 ENOG4105M9M anti-sigma28 factor FlgM M478_1296 ENOG4105QVD Flagella synthesis protein FlgN M478_1298 ENOG4108RS6 transposase M478_1300 ENOG4105W13 flagellar protein M478_1301 ENOG4105D7B Flagellar biosynthesis protein flha M478_1302 ENOG4105D00 flagellar biosynthetic protein flhB M478_1305 ENOG4105NKT exported protein M478_1307 ENOG4105FXM Copper resistance protein M478_1308 ENOG41090A1 ferritin M478_1309 ENOG4105MPK DNA polymerase III subunit theta M478_1311 ENOG4105CUG Oligopeptidase b M478_1314 ENOG4105X2V dna damage-inducible protein M478_1315 ENOG4105C1J atp-dependent rna helicase M478_1318 ENOG4105CRQ synthase (Component I) M478_1320 ENOG4105EJQ L-serine dehydratase M478_1321 ENOG4107UWN reductase M478_1322 ENOG4105EFA 4-hydroxyphenylacetate M478_1327 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase M478_1328 ENOG4105C26 Dehydrogenase M478_1331 ENOG4108V8F Transcriptional regulator, MarR family M478_1334 ENOG4108EQA pts system M478_1335 ENOG4105ETZ PTS System M478_1336 ENOG4105F3R pts system mannose fructose sorbose family iid M478_1341 ENOG4105BZU Histidine kinase M478_1343 ENOG4105DHI Methyltransferase M478_1344 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase M478_1345 ENOG4105VEQ Cold shock protein M478_1348 ENOG4105C85 amino acid M478_1351 ENOG41064PC M478_1352 ENOG4105TIK M478_1353 ENOG4105N4N Protein of unknown function (DUF2766) M478_1357 ENOG4105BZ1 (ABC) transporter M478_1368 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) M478_1372 ENOG4108TSE Transferase M478_1373 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit M478_1375 ENOG4105CG6 trap dicarboxylate transporter dctm subunit M478_1376 ENOG4108KX4 response regulator M478_1378 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme M478_1382 ENOG4105UQX Mate efflux family protein M478_1386 ENOG4105DIA mandelate racemase muconate lactonizing M478_1388 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr M478_1389 ENOG4105KIR Thiol-disulfide oxidoreductase dcc M478_1390 ENOG4105CSP Major Facilitator Superfamily M478_1392 ENOG4105TNG K13735 adhesin invasin M478_1395 ENOG4105CJB Exodeoxyribonuclease I M478_1396 ENOG4105CUB amino acid M478_1398 ENOG4107SCQ Iron-containing alcohol dehydrogenase M478_1399 ENOG4105C2J ABC transporter M478_140 ENOG4105C1J atp-dependent rna helicase M478_1400 ENOG4105C2J ABC transporter M478_1401 ENOG4105CNN ABC, transporter M478_1403 ENOG4108535 NAD dependent epimerase/dehydratase family M478_1405 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) M478_1407 ENOG4105ECC imidazole-glycerol-phosphate dehydratase M478_1408 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) M478_1411 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase M478_1412 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) M478_1413 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase M478_1414 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase M478_1417 ENOG4105CNM Receptor M478_1418 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) M478_1419 ENOG4105DQ5 transport system permease protein M478_142 ENOG4108IYU L-aspartate oxidase M478_1420 ENOG4105TVJ transport system, permease M478_1421 ENOG4105E0A ABC, transporter M478_1422 ENOG4105DUU IucA IucC family protein M478_1424 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) M478_1425 ENOG4105DY8 decarboxylase M478_1426 ENOG4108819 ferric iron reductase M478_1427 ENOG4105EE5 Membrane protein terC M478_1428 ENOG4108GAE asmA family M478_1431 ENOG4105D1F ATP-binding protein M478_1433 ENOG4108RS6 transposase M478_1437 ENOG4105E5W Transporter M478_1439 ENOG41067MG lrgb family M478_144 ENOG41069PW sigma-e factor negative regulatory protein M478_1442 ENOG4107GZ4 SanA protein M478_1443 ENOG4108HWV )-transporter M478_1446 ENOG4105DHF Membrane M478_1448 ENOG4105CBP Major Facilitator M478_1449 ENOG4105EGI Transcriptional regulator M478_145 ENOG4105VQK sigma E regulatory protein, MucB RseB M478_1454 ENOG4105ENT Efflux transporter rnd family, mfp subunit M478_1455 ENOG4105C19 ABC transporter M478_1457 ENOG4105CVM Molybdenum cofactor synthesis domain protein M478_1458 ENOG4105D06 uba thif-type nad fad binding protein M478_146 ENOG4105WMJ Positive regulator of sigma E, RseC MucC M478_1461 ENOG4105C5H ABC transporter M478_1481 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M478_1483 ENOG4105CDV Ompa motb domain protein M478_1489 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase M478_149 ENOG4105C3F Signal peptidase i M478_1490 ENOG41062T2 Acyl carrier protein M478_1492 ENOG4105CHR reductase M478_1493 ENOG4108KQ6 Enoyl-CoA hydratase M478_1495 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase M478_1496 ENOG4105CHR reductase M478_1497 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) M478_1498 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) M478_1505 ENOG4108BUD transposase M478_1507 ENOG4108Z0T Part of a sulfur-relay system (By similarity) M478_1511 ENOG4105K4P CoA-binding domain protein M478_1512 ENOG4108Q67 UPF0319 protein M478_1514 ENOG41088T4 Helicase IV M478_1515 ENOG410901E Membrane M478_1516 ENOG4105EM2 membrane M478_1517 ENOG4108RZ1 DNA transformation protein M478_1519 ENOG4105UYK outer membrane protein a M478_1520 ENOG4108RS6 transposase M478_1522 ENOG4105DAN ATP-dependent protease M478_1525 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) M478_1528 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) M478_1529 ENOG4108RS6 transposase M478_153 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) M478_1530 ENOG4108Q2G (LipO)protein M478_1531 ENOG4105DY2 Paraquat-inducible protein b M478_1532 ENOG4105F1S paraquat-inducible protein a M478_1533 ENOG4105C5H ABC transporter M478_1535 ENOG4105QVC MOSC domain-containing protein M478_1536 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) M478_1538 ENOG4105CD8 aminopeptidase N M478_1542 ENOG4105CGF Aromatic amino acid aminotransferase M478_1543 ENOG4105C5X domain protein M478_1544 ENOG4105EAQ (twin-arginine translocation) pathway signal M478_1545 ENOG4105DIT ErfK YbiS YcfS YnhG family protein M478_1546 ENOG4108RS6 transposase M478_1548 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) M478_1549 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) M478_155 ENOG4108RS6 transposase M478_1550 ENOG4106371 Methyltransferase M478_1551 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups M478_1553 ENOG4105W49 UPF0434 protein M478_1554 ENOG4105VEQ Cold shock protein M478_1555 ENOG4105E32 cytoplasmic protein M478_1558 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 M478_156 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding M478_1561 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) M478_1566 ENOG4105EUR Domain-Containing protein M478_1566 ENOG4105EUR Domain-Containing protein M478_1567 ENOG4105HDK L-asparaginase M478_1568 ENOG4105DDY UPF0142 protein ycaO M478_1569 ENOG4105TMB Formate nitrite transporter M478_157 ENOG4106G6Q Transcriptional regulator M478_1570 ENOG4105C6N Formate acetyltransferase M478_1572 ENOG4105F1A Pyruvate formate-lyase M478_1573 ENOG4108ISG Major Facilitator M478_1576 ENOG4108ISG Major Facilitator M478_1578 ENOG4105D1H recombination factor protein RarA M478_1581 ENOG4105CNU cell division protein FtsK M478_1582 ENOG4105EW9 transcriptional regulator AsnC family M478_1583 ENOG4105C3M thioredoxin reductase M478_1584 ENOG4108JJ9 ABC, transporter M478_1585 ENOG4108JJ8 (ABC) transporter M478_1587 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) M478_1588 ENOG4108RS6 transposase M478_1589 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M478_159 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB M478_1591 ENOG4105VEQ Cold shock protein M478_1593 ENOG4105DJY efflux transporter, rnd family, mfp subunit M478_1594 ENOG4108MJ5 VirK protein M478_1595 ENOG4105CPB ATP-dependent endonuclease of the OLD family M478_1596 ENOG4105DWU Membrane M478_1598 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) M478_1599 ENOG4105C7K acetolactate synthase M478_16 ENOG4108N8T regulatoR M478_160 ENOG4108Z6B deaminase M478_1600 ENOG4105C5W Aldolase M478_1601 ENOG4105CGD Nad-dependent epimerase dehydratase M478_1602 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase M478_1603 ENOG41064MM (LipO)protein M478_1604 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) M478_1605 ENOG4105E5Z arginine transporter ATP-binding subunit M478_1606 ENOG4106PMH Extracellular solute-binding protein family 3 M478_1607 ENOG4105GBT ABC transporter M478_1608 ENOG4105DMR ABC, transporter M478_1609 ENOG4108I0N Transporter, RarD family, DMT superfamily protein M478_1610 ENOG4108MRU Uncharacterized protein conserved in bacteria (DUF2338) M478_1611 ENOG410642S Nicotianamine synthase protein M478_1612 ENOG4105E0A ABC, transporter M478_1613 ENOG4105DQ5 transport system permease protein M478_1618 ENOG4106TNF Periplasmic binding protein M478_1620 ENOG4105RBQ inner membrane protein ybjO M478_1621 ENOG4105D38 putrescine abc transporter M478_1622 ENOG4105F38 ABC transporter, permease M478_1623 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) M478_1624 ENOG4107RUE extracellular solute-binding protein family 1 M478_1625 ENOG4108RMJ sensory transduction regulator M478_1626 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress M478_1627 ENOG41090BQ Glutaredoxin M478_1628 ENOG4105D0C transport protein M478_1630 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase M478_1631 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) M478_1632 ENOG4107FB0 transcriptional regulator DeoR family M478_1633 ENOG4105C44 Serine transporter M478_1634 ENOG4105DZ1 carboxypeptidase M478_1635 ENOG4108UMI ABC transporter, permease M478_1637 ENOG4105D01 (LipO)protein M478_1641 ENOG4108TGY Glutathione S-transferase M478_1642 ENOG4105D05 Receptor M478_1644 ENOG4105EHG Permease protein M478_1646 ENOG4108IQI permease M478_1648 ENOG4105DUM transcriptional regulator, lysR family M478_1649 ENOG4105HMI Membrane M478_1651 ENOG4108D1K outer membrane usher protein M478_1652 ENOG4108UIF Chaperone M478_1655 ENOG4108SGD regulatory protein M478_1656 ENOG4105DM4 PTS System M478_1657 ENOG4105DE4 1-phosphofructokinase M478_1658 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein M478_166 ENOG4108RS6 transposase M478_1660 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane M478_1661 ENOG4105C2J ABC transporter M478_1663 ENOG4105E66 phosphoriboisomerase A M478_1665 ENOG4105C26 Dehydrogenase M478_1668 ENOG4105CHR reductase M478_1669 ENOG4105KRS Proteinase inhibitor M478_167 ENOG4107WP9 Histidine kinase M478_1672 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) M478_1673 ENOG4105DEI Mannitol dehydrogenase M478_1674 ENOG4107YCY Transcriptional regulator M478_1676 ENOG4105CKI cobalamin synthesis protein M478_1677 ENOG41076MN Phosphoesterase, PA-phosphatase related M478_1678 ENOG4107TT5 NLP P60 protein M478_168 ENOG4108SKK alpha helix protein M478_1680 ENOG4105CXC rtn protein M478_1681 ENOG4105E43 Extracellular solute-binding protein, family 5 M478_1682 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component M478_1683 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component M478_1684 ENOG4108JQ5 ABC transporter M478_1685 ENOG4105HG6 M478_1686 ENOG4105C2C drug resistance transporter, Bcr CflA M478_1687 ENOG4105I08 Pseudouridine synthase M478_1688 ENOG4105CFI type iii restriction protein res subunit M478_169 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family M478_1690 ENOG4108RS6 transposase M478_1692 ENOG4105PAN UPF0352 protein M478_1693 ENOG4105E68 Sulfatase M478_1696 ENOG4105GMB type VI secretion system effector, hcp1 family M478_170 ENOG4105C4K Nad synthetase M478_1700 ENOG4105CS2 ec 3.2.1.21 M478_1702 ENOG4108Q3X Transcriptional regulator M478_1706 ENOG4108T86 baseplate J family protein M478_171 ENOG4108YZA Nitrogen regulatory protein pii M478_1714 ENOG4105TKZ Tail Sheath M478_1718 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) M478_1719 ENOG4105MVE transcriptional regulator M478_172 ENOG4108M21 M478_1721 ENOG4105G63 Type III effector Hrp-dependent M478_1722 ENOG4105HRS Antitermination protein M478_1724 ENOG4105Y50 Virulence Protein M478_1726 ENOG4105C8Q Methyl-accepting chemotaxis M478_1728 ENOG4105CT4 transporter M478_1729 ENOG4107R6D beta-lactam binding protein AmpH M478_173 ENOG4108M21 M478_1732 ENOG4108RS6 transposase M478_1733 ENOG4105FCK Membrane M478_1735 ENOG4106UW1 Major Facilitator superfamily M478_1736 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC M478_1737 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC M478_1738 ENOG41068CG regulatoR M478_1739 ENOG4105BZU Histidine kinase M478_1740 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M478_1742 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M478_1743 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M478_1744 ENOG4105XPH Ferredoxin M478_1747 ENOG4105E0U tyrosine-specific transport protein M478_1748 ENOG4108UII YfaZ family M478_1749 ENOG4105CH6 catalase M478_1750 ENOG4105DVT helicase M478_1752 ENOG4105FDR Membrane M478_1754 ENOG4105CXN decarboxylase M478_1755 ENOG4105D5Q Arginine ornithine antiporter M478_1756 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component M478_1757 ENOG4108IJ8 ABC transporter M478_1758 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component M478_176 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) M478_1761 ENOG4105KHC sulfurtransferase M478_1764 ENOG4108IV0 ABC, transporter M478_1765 ENOG4108JJB ABC transporter M478_1766 ENOG4105CNN ABC, transporter M478_1767 ENOG4105C32 Amino acid ABC transporter (Permease) M478_1769 ENOG4108W15 Protein of unknown function (DUF1456) M478_1772 ENOG4106ZX3 phosphonate ABC transporter, periplasmic phosphonate-binding protein M478_1774 ENOG4105Y3U Transglycosylase-associated protein M478_1776 ENOG4105N1F Hnh endonuclease M478_1778 ENOG4105CXG d-lactate dehydrogenase M478_1779 ENOG41061WM D-Alanyl-D-Alanine M478_1781 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) M478_1783 ENOG4108RS6 transposase M478_1784 ENOG4105HFZ Membrane M478_1785 ENOG4108ZAF Molybdopterin M478_1786 ENOG4105M00 molybdopterin converting factor, subunit 1 M478_1788 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) M478_179 ENOG4108MN2 Stationary phase inducible protein CsiE M478_1790 ENOG4105CHW UPF0052 protein M478_1791 ENOG4105VYA Uncharacterized conserved protein (DUF2132) M478_1792 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) M478_1793 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) M478_1794 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) M478_1795 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) M478_18 ENOG4105VEQ Cold shock protein M478_180 ENOG4105D8G Major Facilitator superfamily M478_1800 ENOG4108K4B hydrolase M478_1802 ENOG4105E0C molybdate abc transporter M478_1803 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein M478_1804 ENOG410680R Protein of unknown function (DUF2592) M478_1805 ENOG4105F4R Transcriptional regulator mode M478_1806 ENOG4105DKW ABC transporter M478_1809 ENOG4105CMR udp-glucose 4-epimerase M478_181 ENOG41065CD Exported protein M478_1810 ENOG4105F0Z galactose-1-phosphate uridylyltransferase M478_1813 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) M478_1816 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) M478_1818 ENOG4105PGM cation diffusion facilitator family transporter M478_1819 ENOG4106Z1T Nicotinamide Mononucleotide Transporter M478_182 ENOG4105D7X high-affinity nickel-transporter M478_1824 ENOG4105UFD tol-pal system protein YbgF M478_1825 ENOG4105KCK Peptidoglycan-associated lipoprotein M478_1827 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA M478_1827 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA M478_1828 ENOG4105M8F Biopolymer transport protein exbD tolR M478_1829 ENOG4105E02 MotA TolQ exbB proton channel M478_1830 ENOG4107YD3 Thioesterase M478_1831 ENOG4105KJB cyd operon protein YbgE M478_1833 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii M478_1834 ENOG4105C4M (Ubiquinol oxidase) subunit I M478_1835 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha M478_1837 ENOG4105C7S Dehydrogenase M478_1838 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 M478_1839 ENOG4105E33 succinate dehydrogenase M478_1841 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein M478_1842 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit M478_1843 ENOG4105BZN citrate synthase M478_1845 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) M478_1846 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) M478_1847 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) M478_1849 ENOG4108Z1B Cyclase dehydrase M478_1851 ENOG4108RS6 transposase M478_1852 ENOG4105DFP Integrase M478_186 ENOG4105C3J Cysteine desulfurase M478_1862 ENOG4105VUH addiction module killer protein M478_1868 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease M478_187 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins M478_1870 ENOG4108JDX DNA polymerase iii, epsilon subunit M478_1872 ENOG4105D1A Methyltransferase M478_1874 ENOG4105E9H Lytic Murein transglycosylase M478_1877 ENOG4105CV8 reductase M478_1883 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase M478_1885 ENOG4108UMI ABC transporter, permease M478_1886 ENOG4105D01 (LipO)protein M478_1887 ENOG4108R8X outer membrane lipoprotein M478_1888 ENOG4108R96 Methyltransferase, YaeB family M478_1890 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion M478_1891 ENOG4108YZN class I peptide chain release factor M478_1892 ENOG4108VWS Yaeq family M478_1894 ENOG4105M1T rho-binding antiterminator M478_1896 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) M478_1897 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase M478_1899 ENOG4105C0B DNA polymerase III (alpha subunit) M478_19 ENOG4107Z6W Protein CrcB homolog M478_1901 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) M478_1905 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) M478_1907 ENOG4105DZP Membrane-associated zinc metalloprotease M478_1908 ENOG4105KNE Phosphatidate cytidylyltransferase M478_1909 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) M478_191 ENOG4108ZIT Ferredoxin, 2FE-2S M478_1915 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) M478_1919 ENOG4105QDK Flavodoxin M478_192 ENOG4105WVQ Fe-S assembly protein IscX M478_1920 ENOG4105DR9 pseudouridine synthase M478_1921 ENOG4105WP7 tRNA pseudouridine synthase C M478_1922 ENOG4108RS6 transposase M478_1925 ENOG4105EWT decarboxylase family M478_1929 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease M478_1931 ENOG4105M08 Membrane M478_1932 ENOG4105ETT transcriptional Regulator, LysR family M478_1934 ENOG4105C9B Cysteine desulfurase M478_1935 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) M478_1936 ENOG4105CUZ uba thif-type nad fad binding protein M478_1937 ENOG4105CA3 membrane-bound lytic murein transglycosylase M478_194 ENOG4105YYA enhanced serine sensitivity protein SseB M478_1940 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M478_1942 ENOG4107QYX exodeoxyribonuclease v alpha M478_1943 ENOG4107QKA exodeoxyribonuclease V beta M478_1944 ENOG4107QXK peptidase M478_1945 ENOG4105DSY exodeoxyribonuclease V, gamma M478_1953 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase M478_1956 ENOG4105CPC Aldo Keto reductase M478_196 ENOG4108MGN ATP-binding component of a transport system M478_1962 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) M478_1963 ENOG41060NJ transcriptional regulator M478_1964 ENOG4105F27 Major Facilitator M478_1965 ENOG4105RQF LysR family Transcriptional regulator M478_1966 ENOG4105EJC lysr family transcriptional regulator M478_1968 ENOG4105C8Q Methyl-accepting chemotaxis M478_197 ENOG4108MGN ATP-binding component of a transport system M478_1981 ENOG4105D7Q type ii secretion system M478_1983 ENOG4107QHF type ii secretion system protein e M478_1987 ENOG4107B2H carbonic anhydrase M478_1995 ENOG4107ZSV Receptor M478_1996 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) M478_1997 ENOG4105CFC Transporter M478_2 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) M478_20 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) M478_2005 ENOG4105C1P efflux transporter, rnd family, mfp subunit M478_2007 ENOG4105BZU Histidine kinase M478_2008 ENOG4105DQ6 Transposase M478_2010 ENOG4105CT4 transporter M478_2012 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) M478_2013 ENOG4105DUU IucA IucC family protein M478_2032 ENOG4105CDV Ompa motb domain protein M478_2034 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M478_2047 ENOG4105CXN decarboxylase M478_2048 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M478_2049 ENOG4105C2J ABC transporter M478_205 ENOG4105N21 Membrane M478_2050 ENOG4105CNN ABC, transporter M478_2055 ENOG4105CEN a g-specific adenine glycosylase M478_2057 ENOG41090ED Protein with unknown function (DUF469) M478_2058 ENOG4105CSV Glutaminase M478_2059 ENOG4105K33 Periplasmic Protein M478_206 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) M478_2060 ENOG4105K33 Periplasmic Protein M478_2061 ENOG4105EUK rtx toxin RtxA M478_2062 ENOG4105CSA Coproporphyrinogen iii oxidase M478_2063 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) M478_2065 ENOG4108VIA integral membrane protein M478_2066 ENOG4105II7 pyrroline-5-carboxylate reductase M478_2067 ENOG4105DFA alanine racemase domain protein M478_2068 ENOG4105CZX twitching motility protein M478_2070 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) M478_2073 ENOG4105D7Z glutathione synthase M478_2074 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) M478_2075 ENOG4105RWS endonuclease I M478_2079 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) M478_2081 ENOG4108K0D peptidase, M48 M478_2082 ENOG4105CV1 Transketolase (EC 2.2.1.1) M478_2086 ENOG4105D2N Aldolase M478_2087 ENOG4105D64 Mechanosensitive ion channel M478_2089 ENOG4105MPN Membrane M478_209 ENOG4105VPD cellular component movement M478_2091 ENOG4105E66 phosphoriboisomerase A M478_2092 ENOG4108JQ1 Dehydrogenase M478_2093 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase M478_2096 ENOG4107RAQ aminopeptidase M478_2097 ENOG4105D0A hydroxylase M478_2098 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family M478_2106 ENOG4108UT2 hemolysin iii M478_211 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) M478_2113 ENOG4105Y75 tpr repeat protein M478_2114 ENOG4105E3W Two component transcriptional regulator (Winged helix family M478_2115 ENOG4105EB3 Histidine kinase M478_2116 ENOG4105CT7 inner membrane cred family protein M478_2117 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) M478_2118 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) M478_2119 ENOG4105T95 Thiol disulfide interChange protein M478_2120 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) M478_2124 ENOG4105DFP Integrase M478_2128 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation M478_2129 ENOG4105WJ3 XRE family Transcriptional regulator M478_213 ENOG4108RS6 transposase M478_214 ENOG4108WC9 type VI secretion system effector, hcp1 family M478_2146 ENOG4105NTW Transcriptional regulator M478_2147 ENOG4108UY0 (LipO)protein M478_2149 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M478_2150 ENOG4105CNN ABC, transporter M478_2153 ENOG4107FKK extracellular solute-binding protein family 1 M478_2155 ENOG4105EG2 ABC transporter, permease M478_2157 ENOG4105C4C beta-galactosidase M478_2158 ENOG4105CI1 PTS System M478_2160 ENOG4105ETE Transcriptional regulator (LacI family M478_2162 ENOG4105DPW Major facilitator superfamily MFS_1 M478_2163 ENOG4105ETE Transcriptional regulator (LacI family M478_2166 ENOG4105D2N Aldolase M478_2168 ENOG4105ENH Sulfatase M478_2169 ENOG4105C4X radical SAM domain protein M478_2171 ENOG4105CHR reductase M478_2172 ENOG4105CE4 GlcNAc 6-P deacetylase M478_2173 ENOG4108YTN IIa component M478_2174 ENOG4105F3R pts system mannose fructose sorbose family iid M478_2175 ENOG4105ETZ PTS System M478_2176 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB M478_2177 ENOG4105E70 isomerase M478_2178 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of M478_2179 ENOG4105E98 transcriptional regulator DeoR family M478_2180 ENOG4105CBG Sulfatase M478_2186 ENOG4105C0W non-ribosomal peptide synthetase M478_2188 ENOG4105C0W non-ribosomal peptide synthetase M478_2194 ENOG4105BZ1 (ABC) transporter M478_2198 ENOG4107EFN gluconate transport system permease 3 M478_2204 ENOG4105CS6 Rhs element vgr protein M478_2206 ENOG4105CNA YD repeat protein M478_2208 ENOG41062WK cellular response to acidity M478_2209 ENOG4105C8P )-transporter M478_2210 ENOG4105ETE Transcriptional regulator (LacI family M478_2211 ENOG4105DQ6 Transposase M478_2215 ENOG4108M3R transcriptional activator CadC M478_2219 ENOG4105E1Q flagellar hook-associated protein M478_2221 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) M478_2222 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) M478_2223 ENOG4105CGA flagellar basal-body rod protein FlgG M478_2224 ENOG4108KPB Flagellar basal-body rod protein FlgF M478_2225 ENOG4105BZE flagellar hook protein, FlgE M478_2226 ENOG4105W00 Flagellar hook capping protein M478_2227 ENOG4108ZC9 flagellar basal-body rod protein flgc M478_2228 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) M478_2229 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA M478_223 ENOG4105DWF phosphomethylpyrimidine kinase M478_2233 ENOG4108JIR Flagellum-specific ATP synthase M478_2236 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) M478_2238 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family M478_2240 ENOG4105DD5 Flagellar motor switch protein M478_2241 ENOG4105CN7 Flagellar biosynthetic protein FliP M478_2242 ENOG4105VS8 Flagellar biosynthetic protein fliq M478_2243 ENOG4105D19 Role in flagellar biosynthesis (By similarity) M478_2244 ENOG4105D00 flagellar biosynthetic protein flhB M478_2249 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein M478_2251 ENOG4106P2F Pfam:Pili_assembly_C M478_2252 ENOG4106PG1 outer membrane usher protein M478_2253 ENOG4108RS6 transposase M478_226 ENOG4108ZGU inhibitor of vertebrate lysozyme M478_2267 ENOG4108ZZF transport protein (ExbD) M478_2269 ENOG4105CWK Biopolymer transport protein, ExbB M478_2270 ENOG4105C28 cystathionine M478_2271 ENOG4108K81 inner membrane protein YghB M478_2272 ENOG4105CF7 AraC family transcriptional regulator M478_2273 ENOG4108I6A alcohol dehydrogenase M478_2274 ENOG4105CV8 reductase M478_2277 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) M478_2278 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase M478_2279 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M478_228 ENOG4105CFP Peptidase U32 M478_2280 ENOG4105NF4 modulator of drug activity M478_2281 ENOG4105CR8 Transcriptional regulator M478_2282 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M478_2283 ENOG4105IPS esterase M478_2284 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) M478_2285 ENOG4108SX3 cytoplasmic protein M478_2286 ENOG41087AY ADP-Ribose pyrophosphatase M478_2287 ENOG4105DFG type I secretion outer membrane protein M478_229 ENOG4105KWI UPF0339 protein M478_2290 ENOG4106032 Glutathionylspermidine synthase M478_2291 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b M478_2294 ENOG4105W0Z cytoplasmic protein M478_2295 ENOG4105DVH amino acid M478_2298 ENOG4105I7R Adenylate cyclase M478_2299 ENOG4106MWK domain protein M478_230 ENOG4105E3W Two component transcriptional regulator (Winged helix family M478_2302 ENOG4107ZVW dihydroneopterin aldolase M478_2305 ENOG4105VCC 30S ribosomal protein S21 M478_2306 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) M478_2307 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M478_231 ENOG4105EB3 Histidine kinase M478_2322 ENOG4105KME endoribonuclease L-psp M478_2326 ENOG4105CHM Aminotransferase M478_2329 ENOG4105J12 Multidrug resistance protein mdtN M478_2330 ENOG4108MI0 Resistance protein M478_2332 ENOG4107QK4 glycoside hydrolase, family 3 domain protein M478_2334 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component M478_2336 ENOG4108IJG ABC transporter substrate-binding protein M478_2337 ENOG4107KJX Transcriptional regulator M478_2338 ENOG4107T40 Inherit from COG: Glycosyltransferase 36 M478_2344 ENOG4105CKT filamentous hemagglutinin M478_2346 ENOG4105CKT filamentous hemagglutinin M478_2348 ENOG4105CKT filamentous hemagglutinin M478_2349 ENOG4105D5K Hemolysin activator protein M478_2350 ENOG4108M24 von Willebrand factor, type A M478_2353 ENOG4108M24 von Willebrand factor, type A M478_2356 ENOG4108YK4 Acid-resistance membrane protein M478_2357 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase M478_236 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) M478_2360 ENOG4108VKG metal-dependent hydrolase M478_2361 ENOG4105EE0 oxidoreductase M478_2364 ENOG4108RS6 transposase M478_2365 ENOG4105P66 Membrane M478_2366 ENOG4105CTX dehydratase M478_2367 ENOG4107QZW Altronate oxidoreductase M478_2369 ENOG4105DPW Major facilitator superfamily MFS_1 M478_2372 ENOG4106W5V Membrane M478_2375 ENOG4105NE1 Conserved Protein M478_2376 ENOG41090KG Inner membrane protein YqjE M478_2378 ENOG4108VBZ doxx family M478_2379 ENOG4105CHF Glutathione S-transferase M478_238 ENOG4108JPW Aminotransferase M478_2382 ENOG4105M6F mutator MutT protein M478_2387 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) M478_2388 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) M478_2389 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) M478_2393 ENOG4105CNI cell division protein FtsW M478_2396 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) M478_2397 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) M478_2398 ENOG4105CJN penicillin-binding protein M478_2399 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) M478_24 ENOG4105DZ1 carboxypeptidase M478_240 ENOG4105F38 ABC transporter, permease M478_2402 ENOG4108RNS Exports L-alanine (By similarity) M478_2403 ENOG4107B7Y DNA-binding transcriptional regulator FruR M478_2404 ENOG4108RS6 transposase M478_2405 ENOG4108ZP8 Acetolactate synthase small subunit M478_2406 ENOG4105C7K acetolactate synthase M478_2407 ENOG4108IQE Amp-dependent synthetase and ligase M478_2408 ENOG41064T2 transcriptional regulator, lysR family M478_241 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component M478_2410 ENOG4108RS6 transposase M478_2414 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain M478_2415 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain M478_2416 ENOG4105N14 lysine exporter protein LysE YggA M478_2417 ENOG4105DWK Membrane M478_2419 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) M478_242 ENOG4105R8A Heat shock protein M478_2425 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) M478_2426 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) M478_2428 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) M478_2429 ENOG4105D3G Pseudouridine synthase M478_243 ENOG4105CJW magnesium transporter M478_2438 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M478_2439 ENOG4105CS6 Rhs element vgr protein M478_244 ENOG4105C9X ppx gppa phosphatase M478_245 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) M478_2450 ENOG4105CQ2 DNA polymerase M478_2451 ENOG4108KF1 Membrane M478_2453 ENOG4106SMU thiamine transporter membrane protein M478_2454 ENOG4105DP9 ABC transporter M478_2457 ENOG4105S8Q sugar efflux transporter M478_246 ENOG4105C8U phosphate abc transporter M478_2460 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) M478_2462 ENOG4108RS6 transposase M478_2464 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase M478_2467 ENOG4105DTN riboflavin biosynthesis protein ribF M478_2469 ENOG41063Z6 transcriptional regulator, lysR family M478_247 ENOG4105E2Z phosphate ABC transporter (Permease M478_2473 ENOG4106HK8 GPR1 FUN34 yaaH family protein M478_2476 ENOG4108RIR Molybdenum cofactor biosynthesis protein M478_2484 ENOG41065U4 response regulator M478_2485 ENOG4108RH0 Crea protein M478_2488 ENOG4105UEI Transcriptional Regulator AraC Family M478_2489 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) M478_249 ENOG4108C80 FliB family M478_2491 ENOG4107SC1 transglycosylase M478_2494 ENOG4108KHX Diguanylate cyclase M478_2495 ENOG41090EK ompa motb domain protein M478_2496 ENOG4105C5H ABC transporter M478_2497 ENOG4105C5H ABC transporter M478_2499 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase M478_25 ENOG4105K6T rare lipoprotein A M478_250 ENOG4108C80 FliB family M478_2500 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) M478_2501 ENOG4105EAC phosphoserine phosphatase M478_2502 ENOG41062Z9 Membrane M478_2507 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) M478_2508 ENOG4105D9N nucleoside M478_2509 ENOG4105EYA deoxyribonuclease M478_251 ENOG4108MK9 spermidine N(1)-acetyltransferase M478_2510 ENOG4108NRW Phospholipase, patatin family M478_2512 ENOG4105K3G Periplasmic Protein M478_2514 ENOG4105KEG ribosomal-protein-alanine acetyltransferase M478_2515 ENOG4108WPU DNA polymerase III subunit psi M478_2518 ENOG4105YBH Protein of unknown function (DUF1435) M478_2519 ENOG4105BZU Histidine kinase M478_252 ENOG4108V3E phosphoribosylglycinamide formyltransferase M478_2522 ENOG4105BZS acriflavin resistance protein M478_2523 ENOG410624X efflux transporter, rnd family, mfp subunit M478_2526 ENOG4105DKP glycosyl transferase, family 9 M478_2528 ENOG4105DKT Transcriptional regulator M478_2529 ENOG4105DKT Transcriptional regulator M478_2536 ENOG4105RI1 glycoprotein receptor M478_2537 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) M478_2538 ENOG4105DM4 PTS System M478_2539 ENOG4108YRF PTS System M478_2540 ENOG4106R3P AraC family transcriptional regulator M478_2541 ENOG4108XCZ PTS System M478_2543 ENOG4108M3P Membrane M478_255 ENOG4108RS6 transposase M478_2555 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 M478_2560 ENOG4107S2Z UPF0761 membrane protein M478_2561 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 M478_2563 ENOG4105C5F glutamine synthetase M478_2564 ENOG4105CUX Signal transduction histidine kinase M478_2565 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family M478_2566 ENOG4105D4P Coproporphyrinogen iii oxidase M478_2569 ENOG4108RS6 transposase M478_257 ENOG4105K89 arsenate reductase M478_2570 ENOG4108RS6 transposase M478_2571 ENOG4105C2M dna polymerase I M478_2572 ENOG4108Z33 Thiol disulfide Interchange Protein M478_2573 ENOG4105E27 serine threonine protein kinase M478_2574 ENOG4105PC1 Conserved Protein M478_2576 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b M478_258 ENOG4105ERG peptidase m48, ste24p M478_2585 ENOG4105C12 Phosphoribosylglycinamide synthetase M478_2586 ENOG4108T8B Protein of unknown function (DUF1481) M478_2588 ENOG4105R2J Conserved Protein M478_2589 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) M478_259 ENOG4105C02 permease M478_2594 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) M478_2596 ENOG4105D06 uba thif-type nad fad binding protein M478_2599 ENOG4105D41 biosynthesis protein thiH M478_26 ENOG4105CNI cell division protein FtsW M478_2600 ENOG4108RS6 transposase M478_2608 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) M478_2609 ENOG4105PM1 preprotein translocase subunit SecE M478_2619 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase M478_262 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen M478_2620 ENOG4105D4A Cell wall formation (By similarity) M478_2626 ENOG4108RR8 protoporphyrinogen oxidase M478_2627 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) M478_2628 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein M478_2629 ENOG4108RS6 transposase M478_263 ENOG4105RH4 Glycine cleavage system transcriptional repressor M478_2630 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein M478_2634 ENOG4107QK7 reductase M478_2636 ENOG4105MDZ Transcriptional activator rfaH M478_2637 ENOG4105D52 delta-aminolevulinic acid dehydratase M478_2643 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) M478_2645 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) M478_2647 ENOG4105JC1 sterol-binding domain protein M478_2649 ENOG4105CGY Dna recombination protein M478_265 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) M478_2650 ENOG4108KF1 Membrane M478_2653 ENOG4108I5U Uridine phosphorylase M478_2654 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) M478_2656 ENOG4105EMK carboxylate amino acid amine transporter M478_2657 ENOG4105DZ2 Transcriptional regulator M478_2658 ENOG4105RK9 auxin efflux carrier M478_2659 ENOG4107T6V glycerophosphoryl diester phosphodiesterase M478_266 ENOG4108RS6 transposase M478_2671 ENOG4108IV0 ABC, transporter M478_2672 ENOG4105C0Z ABC transporter M478_2673 ENOG4105CF8 branched-chain amino acid ABC transporter, permease M478_2674 ENOG4105C32 Amino acid ABC transporter (Permease) M478_2675 ENOG4105CP9 extracellular ligand-binding receptor M478_2676 ENOG4105U59 -acetyltransferase M478_2677 ENOG4108RS6 transposase M478_2679 ENOG4105CRP Part of the ABC transporter FtsEX involved in M478_268 ENOG4105CGZ zinc metallopeptidase M478_2680 ENOG4105CAK Cell division ATP-binding protein ftsE M478_2681 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) M478_2681 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) M478_2682 ENOG4106H78 methyltransferase M478_2683 ENOG4105MG3 Membrane M478_2686 ENOG4107FS9 Membrane M478_2689 ENOG4105EX9 Membrane M478_2690 ENOG4108W1V Lipoprotein M478_2691 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) M478_2693 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A M478_2694 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase M478_2696 ENOG4105DQF Hydrolase M478_2697 ENOG4108EUD Lysophospholipase M478_2699 ENOG4105CCF Lysine exporter protein (Lyse ygga) M478_27 ENOG4105CJN penicillin-binding protein M478_2700 ENOG4105C9U ATP-dependent DNA helicase RecQ M478_2701 ENOG4105HDD phospholipase M478_2702 ENOG4108VUY thioesterase Superfamily protein M478_2703 ENOG4105FR1 rard protein M478_2704 ENOG4107QUT magnesium and cobalt transport protein CorA M478_2706 ENOG4105EQN UPF0261 protein M478_2708 ENOG4105C4R Atp-dependent dna helicase M478_2709 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant M478_2710 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) M478_2711 ENOG4105CT0 Protein of unknown function, DUF484 M478_2713 ENOG4105S7Z (LipO)protein M478_2715 ENOG4107T0K Adenylate cyclase M478_2717 ENOG41076E6 Uroporphyrinogen-III Synthase M478_2718 ENOG4105ECF c-methyltransferase M478_2719 ENOG410601J HemY protein M478_2726 ENOG4105C85 amino acid M478_2730 ENOG4105EGZ biosynthesis protein M478_2731 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase M478_2732 ENOG4108WJ1 acetyltransferase M478_2733 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) M478_2734 ENOG4105C1B dTDP-glucose 4-6-dehydratase M478_2735 ENOG4108IJ1 Dehydrogenase M478_2736 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase M478_2737 ENOG4105SFE lipopolysaccharide biosynthesis protein M478_2738 ENOG4105ESV Glycosyl transferase, family 4 M478_274 ENOG4105KUZ arsenate reductase M478_2740 ENOG4105K63 Thioredoxin M478_2744 ENOG4105C4R Atp-dependent dna helicase M478_2745 ENOG4105KQ5 peptidylprolyl cis-trans isomerase M478_2749 ENOG4105GQR Chaperone M478_2750 ENOG4105CW0 outer membrane usher protein M478_2752 ENOG4108VEV chaperone M478_2759 ENOG4105EMY transcriptional regulator M478_276 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC M478_2765 ENOG4105C7B Threonine dehydratase M478_2767 ENOG4105CM2 brancheD-chain amino acid aminotransferase M478_2768 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit M478_277 ENOG4107Z33 ABC transporter, permease M478_2770 ENOG4105C0P Mg chelatase subunit ChlI M478_2771 ENOG4108WFC UPF0438 protein yifE M478_2772 ENOG41062B0 ABC transporter, permease M478_2774 ENOG4107R9N ABC transporter M478_2775 ENOG4105C2J ABC transporter M478_2776 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator M478_278 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) M478_2786 ENOG4108Y73 Membrane M478_2788 ENOG4105C5Q Transcriptional regulator M478_279 ENOG4105ENH Sulfatase M478_2790 ENOG4105EHV domain protein M478_2791 ENOG4107QN2 dihydrolipoyl dehydrogenase M478_2792 ENOG4105YHG TonB family M478_2793 ENOG4107QZV Type I secretion membrane fusion protein M478_2796 ENOG4105X58 receptor M478_280 ENOG4105C4X radical SAM domain protein M478_2800 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase M478_2804 ENOG4105DQ6 Transposase M478_2805 ENOG4105SYT Methylenetetrahydrofolate reductase M478_2806 ENOG4105CFH Aspartokinase M478_2807 ENOG4105C28 cystathionine M478_2809 ENOG4108Z12 YiaAB two helix domain-containing protein M478_281 ENOG4105S2T inner membrane protein YbcI M478_2811 ENOG4105C25 Primosomal protein n' M478_2813 ENOG4105ETE Transcriptional regulator (LacI family M478_2814 ENOG41063M6 Cell Division Protein M478_2817 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase M478_2821 ENOG4108MBX Secretion Protein M478_2822 ENOG4108JJA ABC, transporter M478_2828 ENOG4108RS6 transposase M478_283 ENOG4105BZS acriflavin resistance protein M478_2830 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) M478_2831 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) M478_2832 ENOG4105CBT Fructose-1,6-bisphosphatase M478_2833 ENOG4105DP0 ferredoxin-NADP reductase M478_2834 ENOG4108VTS Membrane M478_2835 ENOG4105EBK exported protein M478_2837 ENOG4107F9Y LysR family transcriptional regulator M478_2839 ENOG4105JSC dimethylmenaquinone methyltransferase M478_2840 ENOG4107QPK )-transporter M478_2842 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein M478_2847 ENOG4105FMW periplasmic M478_2848 ENOG4105E3W Two component transcriptional regulator (Winged helix family M478_2849 ENOG4105E0F Histidine kinase M478_285 ENOG4105WH1 Two component transcriptional regulator luxr family M478_2850 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) M478_2851 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) M478_2852 ENOG4105D7W serine acetyltransferase M478_2855 ENOG4105VW4 glutaredoxin 3 M478_2856 ENOG4107YZP Rhodanese domain protein M478_2858 ENOG41063SB peptidase M478_2859 ENOG4105PXI polysaccharide deacetylase M478_286 ENOG4108ZNS ferredoxin-type protein NapF M478_2860 ENOG4105PXI polysaccharide deacetylase M478_2862 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) M478_2864 ENOG4105XA0 heptosyltransferase ii M478_2865 ENOG4105D16 lipopolysaccharide heptosyltransferase i M478_2866 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase M478_287 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase M478_2870 ENOG4105W0E 50S ribosomal protein L33 M478_2873 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase M478_2878 ENOG4105DSJ YicC domain protein M478_2879 ENOG4105EN6 Membrane M478_2880 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) M478_2883 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) M478_2884 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase M478_2885 ENOG4105CB5 ATP-dependent DNA helicase recG M478_2886 ENOG4105D6U Sodium Glutamate Symporter M478_2887 ENOG4105C2W permease M478_2888 ENOG4105JV1 AsmA family M478_2889 ENOG4105SUU thioesterase domain M478_2892 ENOG4105CHF Glutathione S-transferase M478_2893 ENOG4105CWB LysR family transcriptional Regulator M478_2894 ENOG4108CNN domain protein M478_2895 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) M478_2899 ENOG4105W4M Transport-associated protein M478_29 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) M478_290 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) M478_2901 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain M478_2902 ENOG4105BZU Histidine kinase M478_2903 ENOG4105N5T Radical SAM Protein M478_2904 ENOG4105CBC glutamate synthase M478_2905 ENOG4105BZ8 glutamate synthase M478_2907 ENOG4105KB2 stringent starvation protein b M478_2908 ENOG4107MKT Stringent starvation protein a M478_291 ENOG4105CUW cytochrome C-TYPE protein M478_2911 ENOG4105D6Z AFG1 family ATPase M478_2912 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III M478_2913 ENOG4105C0H protease M478_2914 ENOG4108RS6 transposase M478_2915 ENOG4105C0H protease M478_2917 ENOG4105VFK BolA family M478_2918 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane M478_2919 ENOG4105E3I toluene tolerance M478_2920 ENOG4107PE3 Mammalian cell entry related domain protein M478_2921 ENOG4105CY3 ABC transporter, permease M478_2922 ENOG4105DHJ ABC, transporter M478_2923 ENOG4105FEU K -dependent Na -Ca exchanger M478_2924 ENOG4105C2X Arabinose 5-phosphate isomerase M478_2925 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase M478_2926 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) M478_2927 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA M478_2928 ENOG4108IUZ ABC transporter M478_2929 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M478_293 ENOG4105C6K Malic enzyme M478_2930 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA M478_2931 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN M478_2933 ENOG41080Z8 PHOSPHOCARRIER protein M478_2936 ENOG4105KME endoribonuclease L-psp M478_2938 ENOG4105D4X repressor M478_2939 ENOG4105C5Y PTS System M478_2940 ENOG4105CG3 alpha amylase, catalytic region M478_2941 ENOG4105NXH GreA GreB family elongation factor M478_2942 ENOG4108XVM Cytochrome b(562) M478_2944 ENOG4105CMS peptidase U62, modulator of DNA gyrase M478_2946 ENOG4105UNR (Barnase) inhibitor M478_2949 ENOG4105C26 Dehydrogenase M478_2953 ENOG4105CR8 Transcriptional regulator M478_2963 ENOG4105D1U peptidase U62 modulator of DNA gyrase M478_2965 ENOG4105QD6 exported protein M478_2966 ENOG4105C03 ribonuclease M478_2968 ENOG4105VQ7 Rod shape-determining protein MreD M478_2969 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) M478_2970 ENOG4105DFF Rod shape-determining protein mreb M478_2971 ENOG41062P1 Diguanylate cyclase phosphodiesterase M478_2972 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family M478_2973 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) M478_2976 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein M478_2977 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase M478_2979 ENOG4105RG0 Membrane M478_2980 ENOG4108IA2 Sodium pantothenate symporter M478_2982 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) M478_2983 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) M478_2986 ENOG4105CSH Transporter M478_2987 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase M478_2990 ENOG4108XTF Outer Membrane Lipoprotein M478_2991 ENOG4105VEQ Cold shock protein M478_2992 ENOG4105VEQ Cold shock protein M478_2993 ENOG4108RS6 transposase M478_2996 ENOG4105CYM Glutathione S-transferase M478_2997 ENOG4105C2X Arabinose 5-phosphate isomerase M478_2998 ENOG4105EF1 ribulokinase M478_3 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M478_300 ENOG4105H4F exported protein M478_3000 ENOG4105CNN ABC, transporter M478_3001 ENOG4105C2J ABC transporter M478_3003 ENOG4105D1S lipid A biosynthesis M478_3005 ENOG4105EEQ Na H antiporter M478_3006 ENOG4105C7N Xanthine uracil vitamin C permease M478_3009 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component M478_301 ENOG4105E7K (LipO)protein M478_3011 ENOG4105GVF (ABC) transporter M478_3013 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) M478_3014 ENOG4108RVA ribokinase M478_3015 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) M478_3016 ENOG4105W4W Transcriptional regulator M478_3017 ENOG4107TYG Oxidoreductase domain-containing protein M478_302 ENOG4105EZR dyp-type peroxidase family protein M478_3020 ENOG4105CNA YD repeat protein M478_3022 ENOG4105CS6 Rhs element vgr protein M478_3028 ENOG4105CNA YD repeat protein M478_3031 ENOG4105CS6 Rhs element vgr protein M478_3039 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M478_3054 ENOG4108WC9 type VI secretion system effector, hcp1 family M478_3056 ENOG4107W52 maltose operon periplasmic protein M478_3060 ENOG4107FKK extracellular solute-binding protein family 1 M478_3061 ENOG4105D56 permease protein M478_3062 ENOG4105EG2 ABC transporter, permease M478_3065 ENOG4105CFH Aspartokinase M478_3069 ENOG4105C3R Methionine synthase M478_307 ENOG4108R66 Conserved Protein M478_3070 ENOG41069M3 Transcriptional regulator M478_3071 ENOG41069M3 Transcriptional regulator M478_3073 ENOG4108I9X Isocitrate lyase M478_3074 ENOG4107QP3 malate synthase g M478_308 ENOG4105QEK Transcriptional regulator M478_3084 ENOG4107EJG GntR family transcriptional regulator M478_3086 ENOG4105C0R drug resistance transporter emrb qaca subfamily M478_3087 ENOG4108RVA ribokinase M478_3093 ENOG4108VVK transcriptional Regulator, AsnC M478_3094 ENOG4105QTB Flavodoxin M478_3097 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation M478_3099 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) M478_31 ENOG4105DJF DNA polymerase III, delta' subunit M478_310 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein M478_3107 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) M478_3108 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) M478_3109 ENOG4105C8U phosphate abc transporter M478_311 ENOG4108I5D sulfate abc transporter M478_3110 ENOG4105E2Z phosphate ABC transporter (Permease M478_3114 ENOG4106PMH Extracellular solute-binding protein family 3 M478_3115 ENOG4105EAD ABC transporter M478_3116 ENOG4105DRP amino acid AbC transporter M478_3117 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 M478_3118 ENOG4105C7N Xanthine uracil vitamin C permease M478_312 ENOG4105ECW sulfate abc transporter M478_3123 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins M478_3126 ENOG4105VG0 50S ribosomal protein l34 M478_3129 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) M478_313 ENOG4108IJ6 ABC transporter M478_3130 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) M478_3131 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M478_3132 ENOG410667J hydrolase M478_3133 ENOG4105DQ6 Transposase M478_3137 ENOG4105C7B Threonine dehydratase M478_3138 ENOG4105D99 atp gtp-binding protein M478_3139 ENOG4105D99 atp gtp-binding protein M478_314 ENOG4105C6T cysteine synthase M478_3140 ENOG4105R2A (LipO)protein M478_3144 ENOG4105JKW Valine--pyruvate aminotransferase M478_3146 ENOG4107T9C Alpha amylase catalytic region M478_3149 ENOG4108ZG0 Ompa motb domain protein M478_3151 ENOG4108R3E Dna-3-methyladenine glycosylase i M478_3155 ENOG4106JH6 (LipO)protein M478_3156 ENOG4105CTS PTS system mannitol-specific M478_3158 ENOG4105E61 Mannitol repressor protein M478_316 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M478_3160 ENOG4108YYI Protein of unknown function (DUF2810) M478_3164 ENOG4105C8Q Methyl-accepting chemotaxis M478_3165 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) M478_3167 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) M478_3168 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) M478_3169 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein M478_317 ENOG41062D9 Histidine kinase M478_3170 ENOG4108MG3 formate dehydrogenase M478_3173 ENOG4105EM7 Selenocysteine-specific translation elongation factor M478_3174 ENOG4105D13 transposase M478_3180 ENOG4105DQ6 Transposase M478_3182 ENOG4105MEV Acyl-transferase M478_3183 ENOG4106EAR Fimbrial protein M478_3186 ENOG4108TTM chaperone M478_3188 ENOG4105CMG Carbohydrate kinase M478_319 ENOG4105C87 Aminotransferase class I and II M478_3190 ENOG4105DFW ABC transporter M478_3192 ENOG4107RNG ABC transporter M478_3193 ENOG4105T16 Transcriptional regulator (AraC family) M478_3195 ENOG4105DFP Integrase M478_3197 ENOG4105ZTC transcriptional activator, Ogr delta M478_3202 ENOG4108IPW abc transporter atp-binding protein M478_3204 ENOG4105CM4 permease protein M478_321 ENOG4107RAQ aminopeptidase M478_3210 ENOG4105C6T cysteine synthase M478_3212 ENOG4105C84 Histidine ammonia-lyase M478_3213 ENOG4105C85 amino acid M478_3215 ENOG4105DIJ Phosphoethanolamine transferase M478_3216 ENOG4108KX4 response regulator M478_3217 ENOG4105BZU Histidine kinase M478_3220 ENOG4108Z0R Transferase M478_3223 ENOG4108WI1 Dna topoisomerase M478_3225 ENOG4105C79 DNA protecting protein DprA M478_3229 ENOG4105C1A potassium transporter peripheral membrane M478_323 ENOG4105E1V na solute symporter M478_3231 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system M478_3232 ENOG4105W1Y Transcriptional regulator M478_3235 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) M478_3238 ENOG41067V7 50S ribosomal protein L36 M478_3239 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) M478_3241 ENOG4105VPB 50S ribosomal protein L30 M478_3250 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal M478_3252 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) M478_3253 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) M478_3255 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) M478_326 ENOG4105DJY efflux transporter, rnd family, mfp subunit M478_3263 ENOG4108RS6 transposase M478_3266 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) M478_327 ENOG4105E3W Two component transcriptional regulator (Winged helix family M478_3271 ENOG4105WWK YheO domain protein M478_3272 ENOG4108V1T peptidylprolyl cis-trans isomerase M478_3274 ENOG4108YZY peptidylprolyl cis-trans isomerase M478_3275 ENOG4105VKU nucleicacid-binding protein M478_3278 ENOG4105C5H ABC transporter M478_3279 ENOG4105C5H ABC transporter M478_328 ENOG4105E0F Histidine kinase M478_3280 ENOG4105K64 Glycosyl transferase, family 2 M478_3282 ENOG4105E2B Taurine dioxygenase M478_3283 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component M478_3285 ENOG4106FTQ Taurine ABC transporter, periplasmic M478_3287 ENOG4105DNZ Alpha Beta Hydrolase M478_3289 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) M478_3291 ENOG4108UKZ OsmC family M478_3293 ENOG410613R integral membrane protein, YccS YhfK family M478_3294 ENOG4105C8Y Acetylornithine aminotransferase M478_3296 ENOG4105D7A ATP-binding protein M478_3297 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) M478_3298 ENOG4105F8D glycoside hydrolase family 4 M478_3299 ENOG41060NJ transcriptional regulator M478_330 ENOG4108RS6 transposase M478_3302 ENOG4105DZC cytosine deaminase M478_3303 ENOG4107QZF nitrite reductase NADPH large subunit M478_3304 ENOG4105WZK nitrite reductase NADPH small subunit M478_3305 ENOG4107V9H nitrite transporter M478_3307 ENOG4105C31 Tryptophanyl-tRNA synthetase M478_3308 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) M478_3309 ENOG4105DJV ribulose-phosphate 3-epimerase M478_331 ENOG4105C5Y PTS System M478_3314 ENOG4105E4G Type IV pilus M478_3319 ENOG4108JQC penicillin-binding protein 1A M478_3320 ENOG4107RK2 ADP-ribose diphosphatase NudE M478_3322 ENOG4105DQY intracellular growth attenuator M478_3323 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 M478_3324 ENOG4105VEJ Heat shock protein M478_3327 ENOG4105E0F Histidine kinase M478_3328 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M478_3329 ENOG4108RRZ Transcription elongation factor GreB M478_333 ENOG4105KZ7 phosphocarrier protein hpr M478_3330 ENOG4105BZM domain protein M478_3331 ENOG4105XFK Ferrous iron transport protein A M478_3332 ENOG4105CE1 Ferrous iron transport protein b M478_3334 ENOG4105RID UPF0379 protein yhcN M478_3336 ENOG4105MJ2 Competence protein M478_3338 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) M478_3339 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) M478_334 ENOG4105C6T cysteine synthase M478_3340 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) M478_3344 ENOG4105E98 transcriptional regulator DeoR family M478_3346 ENOG4105DQ6 Transposase M478_3349 ENOG4105C6V Glycerol-3-phosphate dehydrogenase M478_335 ENOG4105EXN Sulfate transport protein CysZ M478_3350 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) M478_3355 ENOG4108HRK Histidine kinase M478_3361 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) M478_3362 ENOG41076UM multiple antibiotic resistance (MarC)-related protein M478_3366 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family M478_3367 ENOG4105C6Z Gluconate M478_3368 ENOG4105DIQ Transcriptional regulator M478_3369 ENOG4105C2I pirin domain protein M478_3371 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M478_3373 ENOG4105D2N Aldolase M478_3375 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M478_3376 ENOG4105CNN ABC, transporter M478_3379 ENOG4105CBX hi0933 family M478_338 ENOG4105VRT cytoplasmic protein M478_3380 ENOG4105CJ3 phosphate transporter M478_3381 ENOG4108RS6 transposase M478_3383 ENOG4108M6U Universal stress protein A M478_3387 ENOG4105DGW oligopeptidase A M478_3388 ENOG4105D6S protein involved in catabolism of external DNA M478_3389 ENOG4105DC8 reductase M478_3390 ENOG4107VHA regulatoR M478_3391 ENOG4107QQ0 gntp family M478_3392 ENOG4105BZW Glycerate kinase M478_3397 ENOG4107H3J ribonuclease M478_3398 ENOG41066T0 asmA family M478_3399 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) M478_34 ENOG4107PAI alpha helical protein M478_3400 ENOG4105CMB EAL domain-containing protein M478_3401 ENOG4105VSH 4-oxalocrotonate tautomerase M478_3402 ENOG4107SS6 2-dehydro-3-deoxygluconokinase M478_3403 ENOG4105CS0 peptidase M478_3408 ENOG4108PU9 oligogalacturonate-specific porin M478_3409 ENOG4105BZU Histidine kinase M478_3410 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) M478_3411 ENOG4108JQ7 (ABC) transporter M478_3412 ENOG4105C3U ABC transporter M478_3413 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M478_3414 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M478_3415 ENOG4105DEF Extracellular solute-binding protein, family 5 M478_3417 ENOG4105D5K Hemolysin activator protein M478_3421 ENOG4105CXY transporter M478_3422 ENOG4105BZU Histidine kinase M478_3429 ENOG41062QD Membrane M478_3431 ENOG4105CK2 sodium dicarboxylate symporter M478_3432 ENOG4105WH1 Two component transcriptional regulator luxr family M478_3433 ENOG4105BZU Histidine kinase M478_344 ENOG4108RS6 transposase M478_3446 ENOG4108JIR Flagellum-specific ATP synthase M478_3449 ENOG41063Q7 Type III secretion system protein M478_3450 ENOG4108HHI Type III secretion system protein M478_3451 ENOG41083GP type iii secretion M478_3452 ENOG4108TN6 type iii secretion M478_3453 ENOG4108IUF type iii secretion M478_3454 ENOG41066VF YeeE YedE family protein M478_3455 ENOG4105KSU Redox protein M478_3456 ENOG4105EQ2 LysR family Transcriptional regulator M478_3457 ENOG4105C44 Serine transporter M478_3458 ENOG4105C28 cystathionine M478_3460 ENOG4105EHG Permease protein M478_3461 ENOG4107R4I Periplasmic binding protein M478_3462 ENOG4106QJH hemin transport protein M478_3463 ENOG4107ENK receptor M478_3465 ENOG41090JE Utilization Protein M478_3466 ENOG4105D4P Coproporphyrinogen iii oxidase M478_3470 ENOG4105DAX Pfam:DUF2983 M478_3482 ENOG4108S1B Periplasmic chaperone protein M478_349 ENOG4105D9N nucleoside M478_3490 ENOG41080IJ Diacylglycerol kinase M478_3492 ENOG4105MYN Zinc uptake regulation protein M478_3493 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) M478_3494 ENOG4105P4Z Phage shock protein G M478_3495 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein M478_3496 ENOG4105CDU Replicative dna helicase M478_3497 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) M478_3498 ENOG4105CGF Aromatic amino acid aminotransferase M478_3499 ENOG4105MSB protein, conserved in bacteria M478_35 ENOG4105CDA abc transporter atp-binding protein M478_3500 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) M478_3501 ENOG4108UUM single-stranded DNA-binding protein M478_3503 ENOG4105C0A alcohol dehydrogenase M478_3517 ENOG4108SIC Transcriptional regulator M478_3518 ENOG4105BZ8 glutamate synthase M478_3519 ENOG4108RC0 Electron transport protein M478_352 ENOG4105CPC Aldo Keto reductase M478_3520 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) M478_3523 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter M478_3528 ENOG4108ZVF (LipO)protein M478_3529 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein M478_353 ENOG4105C5Q Transcriptional regulator M478_3531 ENOG4105KPY Small multidrug resistance protein M478_3532 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) M478_3537 ENOG4105EGS Mechanosensitive ion channel M478_3540 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) M478_3544 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) M478_3545 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) M478_3546 ENOG4105K8N protein family UPF0079, ATPase M478_3547 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M478_3551 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) M478_3552 ENOG4107QJR hflk protein M478_3553 ENOG4105EPW hflc protein M478_3557 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) M478_3558 ENOG4105C2N RNA methyltransferase TrmH family group 3 M478_3559 ENOG4105CSU acyl-Coa dehydrogenase M478_356 ENOG41072TH Protein of unknown function (DUF1479) M478_3560 ENOG4105WSB biofilm stress and motility protein A M478_3564 ENOG4108MXZ Esterase M478_3566 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) M478_3567 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) M478_3569 ENOG4108RS6 transposase M478_357 ENOG4105CHM Aminotransferase M478_3571 ENOG4105FHY Opacity-associated protein A M478_3572 ENOG4108V1T peptidylprolyl cis-trans isomerase M478_3574 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic M478_3575 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase M478_3576 ENOG4108UUE Transcriptional regulator M478_3577 ENOG41061GZ Protein of unknown function (DUF1107) M478_3578 ENOG4105C37 (CBS) domain M478_358 ENOG4108VKM cytochrome b561 M478_3580 ENOG4105CFU surface antigen M478_3581 ENOG4105MA0 exported protein M478_3582 ENOG4108ZHD aig2 family M478_3583 ENOG4105F0N pyrophosphate phospho-hydrolase M478_3585 ENOG4105DFU Cell wall formation (By similarity) M478_3589 ENOG4105HVQ Regulatory factor of maltose metabolism M478_3591 ENOG4105EAH synthase M478_3594 ENOG4105QYV Membrane M478_3598 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase M478_3599 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) M478_36 ENOG4105DRP amino acid AbC transporter M478_360 ENOG4106B0W Curli production assembly transport component CsgG M478_3600 ENOG4105HBR Rna-binding protein M478_3602 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) M478_3603 ENOG4105EEI dihydropteroate synthase M478_3609 ENOG4105CHV Transcription elongation factor NusA M478_3615 ENOG4105DQ6 Transposase M478_3618 ENOG4105C1J atp-dependent rna helicase M478_362 ENOG4107Y60 (LipO)protein M478_3621 ENOG4105DEN Luciferase family M478_3624 ENOG4105BZS acriflavin resistance protein M478_3625 ENOG4105ENJ RND efflux system, outer membrane lipoprotein M478_3626 ENOG4106RZ4 Peptidase U32 M478_3627 ENOG4105CFP Peptidase U32 M478_3628 ENOG4105XPQ lipid carrier protein M478_3629 ENOG4108YYD acetyltransferase M478_3634 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component M478_3635 ENOG4105DRS transport system, permease M478_3639 ENOG4105K4T epimerase M478_364 ENOG4108NEM leader-binding protein dmsD M478_3640 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein M478_3641 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) M478_3642 ENOG4105FD8 phosphonate metabolism protein PhnM M478_3643 ENOG4105HRV phosphonate c-p lyase system protein phnl M478_3644 ENOG4105ENV phosphonate C-P lyase system protein PhnK M478_3645 ENOG4105FT8 Phosphonate metabolism M478_3646 ENOG4105EKV Phosphonate metabolism protein M478_3647 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH M478_3648 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG M478_3649 ENOG4107RJJ Transcriptional regulator M478_365 ENOG4107KGK dmso reductase anchor subunit M478_3651 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) M478_3652 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase M478_3653 ENOG4108JQ7 (ABC) transporter M478_3654 ENOG4105C3U ABC transporter M478_3655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M478_3656 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M478_3659 ENOG4105XEP YhcH YjgK YiaL family protein M478_366 ENOG4105QAX Iron-sulfur M478_3660 ENOG4105DBV ornithine carbamoyltransferase M478_3661 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) M478_3662 ENOG4108MJ3 acetyltransferase M478_3663 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) M478_3664 ENOG4105MYG DNA polymerase iii, chi subunit M478_3666 ENOG4108M8S permease YjgP YjgQ family protein M478_3667 ENOG4108K5H permease YjgP YjgQ family protein M478_367 ENOG4107QY8 reductase M478_3671 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) M478_3674 ENOG4108RS6 transposase M478_3677 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) M478_3679 ENOG4105D7Q type ii secretion system M478_3680 ENOG4107QHF type ii secretion system protein e M478_3681 ENOG4108ZUW Major pilin subunit M478_3682 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase M478_3683 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase M478_3684 ENOG4106A72 regulatory protein AmpE M478_3685 ENOG4105C85 amino acid M478_3686 ENOG41073TP transcriptional regulator M478_3687 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) M478_3688 ENOG4107QSN dihydrolipoamide acetyltransferase M478_3689 ENOG4107QN2 dihydrolipoyl dehydrogenase M478_369 ENOG4108WC9 type VI secretion system effector, hcp1 family M478_3690 ENOG4108RS6 transposase M478_3691 ENOG4107QIJ Aconitate hydratase 2 M478_3693 ENOG4105RPH Inner membrane protein YddG M478_3696 ENOG4108ZRK uncharacterized protein yacC M478_3697 ENOG4105E3B Multicopper oxidase M478_3698 ENOG4108UGV hypoxanthine phosphoribosyltransferase M478_3699 ENOG41077A9 carbonic anhydrase M478_37 ENOG4105EAD ABC transporter M478_3700 ENOG4105DA5 (ABC) transporter M478_3701 ENOG4105E3A (ABC) transporter M478_3703 ENOG4107BJW polysaccharide deacetylase M478_3707 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase M478_3708 ENOG4105DJ0 Poly(A) Polymerase M478_3709 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) M478_3710 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters M478_3712 ENOG4107XID 2'-5' rna ligase M478_3713 ENOG4105CQ7 ATP-dependent helicase M478_3714 ENOG4105BZ4 penicillin-binding protein M478_3715 ENOG4105E0A ABC, transporter M478_3716 ENOG4105J76 Periplasmic binding protein M478_3717 ENOG4105S6R Iron-hydroxamate transporter permease subunit M478_3721 ENOG4105EN6 Membrane M478_3723 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) M478_3725 ENOG4105C0H protease M478_3726 ENOG4105BZU Histidine kinase M478_3727 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) M478_3728 ENOG4105DXN mazG family M478_3732 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) M478_3733 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase M478_374 ENOG4105CVE Lytic murein transglycosylase M478_3745 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) M478_3746 ENOG4105N0Z inner membrane protein ygbE M478_3748 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) M478_3753 ENOG4108K5P (LipO)protein M478_3754 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M478_3755 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) M478_3756 ENOG4108YZG isomerase M478_3757 ENOG4105CPQ Dehydrogenase M478_3758 ENOG4105CHR reductase M478_3759 ENOG4105CMT Dihydroxyacetone kinase M478_3761 ENOG4105DKT Transcriptional regulator M478_3765 ENOG4105E89 ABC transporter M478_3766 ENOG4105CA0 peroxidase M478_3768 ENOG4105D05 Receptor M478_3770 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) M478_3772 ENOG4107GFK fumarate M478_3773 ENOG4105CMG Carbohydrate kinase M478_3774 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase M478_3775 ENOG4105F5R ABC transporter M478_3776 ENOG4105CNN ABC, transporter M478_3777 ENOG4105C2J ABC transporter M478_3778 ENOG4108RS6 transposase M478_3780 ENOG4105E98 transcriptional regulator DeoR family M478_3781 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase M478_3782 ENOG4107QY8 reductase M478_3783 ENOG4105QAX Iron-sulfur M478_3784 ENOG4107KGK dmso reductase anchor subunit M478_3785 ENOG4108NEM leader-binding protein dmsD M478_3786 ENOG4105CPW cytochrome b561 M478_3787 ENOG4108XVM Cytochrome b(562) M478_3791 ENOG4105C2J ABC transporter M478_3792 ENOG4105CNN ABC, transporter M478_3793 ENOG4108HHA Transketolase M478_3794 ENOG4108IUS Transketolase M478_3795 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) M478_38 ENOG4107RP9 extracellular solute-binding protein, family 3 M478_3802 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) M478_3803 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) M478_3808 ENOG4107VXZ Hydrolase M478_3809 ENOG4105W39 Membrane M478_3810 ENOG4105D9M gamma-glutamylcysteine synthetase M478_3812 ENOG4108RS6 transposase M478_3813 ENOG4108JU6 CBS domain protein M478_3814 ENOG4106KVJ cytochrome C assembly protein M478_3815 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY M478_3820 ENOG4108RS6 transposase M478_3821 ENOG4108NE3 Salt-induced outer membrane protein M478_3822 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter M478_3823 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter M478_3824 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter M478_3825 ENOG4108NEV two component transcriptional regulator, LytTR family M478_3826 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) M478_3827 ENOG4105EHE chorismate mutase- prephenate dehydrogenase M478_3833 ENOG4105CQC Prephenate dehydratase M478_3834 ENOG4108RS6 transposase M478_3835 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA M478_3836 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane M478_3837 ENOG4105C34 Pseudouridine synthase M478_3838 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase M478_3839 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M478_384 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M478_3846 ENOG4105T42 (LipO)protein M478_3847 ENOG4105JIM Phosphatidylserine synthase M478_3848 ENOG4105CD5 CoA-binding domain protein M478_3849 ENOG4106IUH DTW domain containing protein M478_3850 ENOG4105K63 Thioredoxin M478_3851 ENOG4105EIB trna rrna methyltransferase M478_3852 ENOG4105C0R drug resistance transporter emrb qaca subfamily M478_3853 ENOG4105CW7 secretion protein, HlyD family M478_3854 ENOG4105NTK Transcriptional repressor Mpra M478_3855 ENOG4105ZED uncharacterized protein ygaH M478_3856 ENOG4108UMN azlc family M478_3857 ENOG4105EQ0 Major Facilitator superfamily M478_386 ENOG4105GQR Chaperone M478_3864 ENOG4105E5Q amino acid AbC transporter M478_3866 ENOG4105C5R Aminotransferase M478_387 ENOG4105CW0 outer membrane usher protein M478_3871 ENOG4105C5R Aminotransferase M478_3876 ENOG4106YJS accessory processing protein M478_3878 ENOG4107QPN acyl-Coa dehydrogenase M478_3880 ENOG4105F7V ErfK ybiS ycfS ynhG family protein M478_3881 ENOG4105E7A Glutamine amidotransferase M478_3882 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) M478_3883 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) M478_3884 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) M478_3888 ENOG4105CJ2 (LipO)protein M478_389 ENOG4105CW0 outer membrane usher protein M478_3892 ENOG4105CIN aminoacyl-histidine dipeptidase M478_39 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) M478_3903 ENOG4105F2W methyltransferase M478_3908 ENOG4105DKQ ROK family M478_3909 ENOG4105EYH Exonuclease M478_3910 ENOG4107RH8 nuclease SbcCD subunit D M478_3911 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M478_3912 ENOG4105BZU Histidine kinase M478_3914 ENOG4105CWM branched-chain amino acid transport system II carrier protein M478_3915 ENOG4108RS6 transposase M478_3916 ENOG4105C85 amino acid M478_3917 ENOG4107R28 alpha amylase, catalytic region M478_3918 ENOG4105CHR reductase M478_3921 ENOG4105D3R alkyl hydroperoxide reductase M478_3922 ENOG4108ZYK Acyl carrier protein phosphodiesterase M478_3923 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) M478_3925 ENOG4105VIE preprotein translocase, subunit YajC M478_3926 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) M478_3927 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) M478_3928 ENOG4108RS6 transposase M478_3932 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) M478_3935 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) M478_3936 ENOG4108ZAI phosphatidylglycerophosphatase a M478_3937 ENOG4108RS6 transposase M478_3939 ENOG4105CTB Polyprenyl synthetase M478_3942 ENOG4107S0N DJ-1 family M478_3943 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) M478_3945 ENOG4107RDB Major Facilitator M478_3947 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) M478_3948 ENOG4105CCU oxidase (Subunit III) M478_3949 ENOG4105BZ9 Cytochrome C oxidase, subunit I M478_3950 ENOG4105E2S oxidase) subunit II M478_3951 ENOG4108NFH Sugar hydrolase M478_3952 ENOG4105EYM Major Facilitator superfamily M478_3953 ENOG4105IEY (LipO)protein M478_3954 ENOG4105M85 Bola protein M478_3959 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) M478_3960 ENOG4105K70 DNA-binding protein M478_3961 ENOG4105EIN peptidylprolyl cis-trans isomerase M478_3962 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein M478_3963 ENOG4108TGP Thioesterase superfamily protein M478_3965 ENOG4108NFA extracellular solute-binding protein M478_3967 ENOG4105C6T cysteine synthase M478_3968 ENOG4108XM1 transcriptional regulator AsnC family M478_3969 ENOG4105BZ1 (ABC) transporter M478_3970 ENOG4105BZ1 (ABC) transporter M478_3971 ENOG4108YZA Nitrogen regulatory protein pii M478_3972 ENOG4105BZU Histidine kinase M478_3973 ENOG4105C29 acyl-CoA thioesterase M478_3974 ENOG4108MNP Glycoprotein polysaccharide metabolism M478_3975 ENOG41080UX Methyltransferase M478_3976 ENOG4105KF5 hemolysin expression-modulating protein M478_3977 ENOG4108UKR Biofilm formation regulator YbaJ M478_3979 ENOG4105YK5 50S ribosomal protein L36 M478_3981 ENOG4105BZS acriflavin resistance protein M478_3982 ENOG4105C1P efflux transporter, rnd family, mfp subunit M478_3983 ENOG4108IG5 Transcriptional regulator M478_3984 ENOG41090EX DsrE family M478_3985 ENOG4105EGS Mechanosensitive ion channel M478_3987 ENOG4105WD1 Membrane M478_3989 ENOG4107QMP dna polymerase iii subunits gamma and tau M478_3995 ENOG4108EX3 reductase M478_3996 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase M478_3997 ENOG4105FAW cDP-glucose 4,6-dehydratase M478_3998 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase M478_3999 ENOG4108SMP Nad-dependent epimerase dehydratase M478_4 ENOG4105C2J ABC transporter M478_40 ENOG4108JU5 Magnesium and cobalt efflux protein M478_4007 ENOG4108TJN glycosyl transferase group 1 M478_4008 ENOG4105C0K Gdp-mannose 4,6-dehydratase M478_4009 ENOG4105C0K Gdp-mannose 4,6-dehydratase M478_4010 ENOG4105C30 Nad-dependent epimerase dehydratase M478_4011 ENOG4105CJT Mannose-1-phosphate guanylyltransferase M478_4014 ENOG4108QY5 Ferric enterobactin transport protein M478_4015 ENOG4107RE1 Inosine-guanosine kinase M478_4016 ENOG4105CKD glutathione-regulated potassium-efflux system protein M478_4017 ENOG4105EU0 Major facilitator Superfamily M478_4018 ENOG4105CGH 5'-nucleotidase M478_4019 ENOG4105CGH 5'-nucleotidase M478_402 ENOG4105CS6 Rhs element vgr protein M478_4020 ENOG4105CGH 5'-nucleotidase M478_4023 ENOG4108Z66 YbaK ebsC protein M478_4024 ENOG4105MBR gumn family M478_4025 ENOG4105C59 p-type ATPase M478_4026 ENOG4108Z6Z Transcriptional regulator M478_4027 ENOG4105G5H Membrane M478_4028 ENOG4107QX8 SPFH domain, Band 7 family protein M478_4029 ENOG4107QR8 Thioredoxin M478_4030 ENOG4105E1F short-chain dehydrogenase reductase M478_4031 ENOG4108UJV acyl-CoA thioesterase i M478_4032 ENOG4108I0Y (ABC) transporter M478_4033 ENOG4105CV6 ABC transporter, permease M478_4034 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit M478_4035 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) M478_4037 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) M478_4040 ENOG4105WQ3 Rna-binding protein M478_4048 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase M478_4049 ENOG4108HPI phosphatidate Cytidylyltransferase M478_4051 ENOG4105E8V Alpha Beta Hydrolase Fold protein M478_4052 ENOG41077RS Phosphatase M478_4057 ENOG4105EQ2 LysR family Transcriptional regulator M478_4058 ENOG4107SET aldo keto reductase M478_4061 ENOG4107QK4 glycoside hydrolase, family 3 domain protein M478_4065 ENOG4105EZE Cupin 4 family protein M478_4070 ENOG4108WC9 type VI secretion system effector, hcp1 family M478_4075 ENOG4105HVQ Regulatory factor of maltose metabolism M478_4076 ENOG4108JQB penicillin-binding protein 1C M478_4078 ENOG4108RS6 transposase M478_4079 ENOG4105DN3 alpha-2-macroglobulin domain protein M478_408 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA M478_4084 ENOG4105C26 Dehydrogenase M478_4085 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) M478_4086 ENOG4106JVB Replication Protein M478_4094 ENOG4108RS6 transposase M478_410 ENOG4108V0P LemA family M478_4103 ENOG4105CB5 ATP-dependent DNA helicase recG M478_4104 ENOG4105FA0 parb-like partition protein M478_4105 ENOG4105FA0 parb-like partition protein M478_4125 ENOG4108NYK Tape measure protein M478_4132 ENOG4108X9F tail fiber protein M478_4132 ENOG4108X9F tail fiber protein M478_4134 ENOG4105UZW Tail fiber assembly protein M478_414 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) M478_4141 ENOG4105EQR Transposase IS116 IS110 IS902 M478_415 ENOG41060IM Heme exporter protein M478_4150 ENOG4106RMF ParB family M478_4155 ENOG41073YN Protein of unknown function (DUF1380) M478_4159 ENOG4105FEQ ParB domain protein nuclease M478_416 ENOG4105X3C heme exporter protein M478_4167 ENOG4106PHM regulatory protein M478_4168 ENOG4108UIF Chaperone M478_4169 ENOG4108D1K outer membrane usher protein M478_4176 ENOG4106J5W DNA polymerase III (alpha subunit) M478_418 ENOG4105DA4 cytochrome c-type biogenesis protein M478_4182 ENOG4105C2M dna polymerase I M478_4184 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) M478_419 ENOG4107QX9 Thiol disulfide interChange protein M478_4198 ENOG4105EZN Cobyrinic acid ac-diamide synthase M478_4199 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB M478_42 ENOG4105C9A Phoh family M478_420 ENOG4105KWW Biogenesis protein M478_4205 ENOG4105CMM transposase M478_4209 ENOG4105CMM transposase M478_421 ENOG4105KWW Biogenesis protein M478_4213 ENOG4108C33 Resolvase M478_4215 ENOG4105D13 transposase M478_422 ENOG410903C (LipO)protein M478_4224 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) M478_4225 ENOG4106CQM replication M478_423 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation M478_4234 ENOG4105CMM transposase M478_4236 ENOG4105CMM transposase M478_424 ENOG4105KZW UPF0381 protein M478_427 ENOG4108BY2 phosphohistidine phosphatase M478_4288 ENOG4105XUP Phage derived protein Gp49-like (DUF891) M478_429 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) M478_432 ENOG4105EJ9 Membrane M478_433 ENOG4108BPE -transporting atpase M478_434 ENOG4105MH2 YfcL protein M478_436 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) M478_439 ENOG4106WZ1 flagella biosynthesis regulator M478_44 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family M478_440 ENOG410631K Membrane M478_443 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) M478_445 ENOG4105DQR SNARE associated Golgi M478_447 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase M478_448 ENOG4108S3P Sporulation domain protein M478_449 ENOG4105E96 Colicin v production protein M478_450 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase M478_451 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase M478_452 ENOG4105E89 ABC transporter M478_453 ENOG4105DSP amino acid AbC transporter M478_454 ENOG4106YG3 ABC transporter M478_455 ENOG4108JEH abc transporter atp-binding protein M478_456 ENOG4105ECP epimerase M478_458 ENOG4108RE9 Phosphodiesterase M478_459 ENOG4105PTV Nudix Hydrolase M478_460 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC M478_464 ENOG4107P2S Transcriptional regulator M478_465 ENOG4105C6K Malic enzyme M478_469 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 M478_470 ENOG4107QWE )-transporter M478_472 ENOG4105CHM Aminotransferase M478_473 ENOG4107NQ8 LysR family Transcriptional regulator M478_475 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) M478_477 ENOG4105GKE subunit e M478_478 ENOG4107QIZ NADH dehydrogenase M478_479 ENOG4108IEH NADH dehydrogenase subunit g M478_482 ENOG4107UFS subunit j M478_484 ENOG4105D65 subunit l M478_485 ENOG4105C8S subunit m M478_489 ENOG4105CHR reductase M478_490 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family M478_492 ENOG4105F32 YngK protein M478_493 ENOG4105K2J Transcriptional regulator M478_494 ENOG4105C5I Dehydrogenase M478_497 ENOG4105C01 Dihydroxy-acid dehydratase M478_499 ENOG4105TNS Conserved Protein M478_5 ENOG4105CNN ABC, transporter M478_501 ENOG4105E4F Isochorismate synthase M478_504 ENOG4108IPT Naphthoate synthase M478_506 ENOG4105CEY Amp-dependent synthetase and ligase M478_507 ENOG4108MTB glycosyl transferase family M478_508 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction M478_51 ENOG4105CAQ asparagine synthetase M478_512 ENOG4107SDU Methyl-accepting chemotaxis M478_513 ENOG4105CDA abc transporter atp-binding protein M478_514 ENOG4105E5Q amino acid AbC transporter M478_515 ENOG4107R0W ABC transporter M478_52 ENOG4105D4U had-superfamily hydrolase, subfamily iia M478_521 ENOG4108T1M outer membrane protein x M478_525 ENOG4105CPQ Dehydrogenase M478_526 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M478_527 ENOG4105C2J ABC transporter M478_528 ENOG4105CNN ABC, transporter M478_529 ENOG4105FKQ transcriptional regulator M478_53 ENOG4105E2R ROK family M478_530 ENOG4105EJC lysr family transcriptional regulator M478_531 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) M478_532 ENOG4105C94 Transporter M478_533 ENOG4105DVW rieske (2Fe-2S) M478_534 ENOG4105DVW rieske (2Fe-2S) M478_535 ENOG4105E3J oxidoreductase M478_536 ENOG4105D5K Hemolysin activator protein M478_537 ENOG4105CKT filamentous hemagglutinin M478_54 ENOG4105CE4 GlcNAc 6-P deacetylase M478_540 ENOG4105CKT filamentous hemagglutinin M478_543 ENOG4105CKT filamentous hemagglutinin M478_545 ENOG4108IJ9 (ABC) transporter M478_547 ENOG4105ETE Transcriptional regulator (LacI family M478_550 ENOG4105DRS transport system, permease M478_551 ENOG4105HY2 Glycosidase related protein M478_555 ENOG4105CUY Mechanosensitive ion channel M478_556 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) M478_557 ENOG4107IIZ CRISPR-associated helicase, Cas3 M478_558 ENOG4105ENG CRISPR-associated protein, Csy1 family M478_559 ENOG4105DZX CRISPR-associated protein, Csy2 family M478_56 ENOG4105CI1 PTS System M478_560 ENOG4105M6W Crispr-associated protein, Csy3 family M478_561 ENOG4108Y1S CRISPR-associated protein, Csy4 family M478_562 ENOG4105CPC Aldo Keto reductase M478_564 ENOG4105C54 Major Facilitator superfamily M478_566 ENOG4105ETT transcriptional Regulator, LysR family M478_567 ENOG4107YC3 synthase M478_568 ENOG4105VJY transcriptional regulator M478_57 ENOG4108RS6 transposase M478_572 ENOG4105DSF transport protein M478_576 ENOG4105D5G Transposase M478_578 ENOG41067V3 Antibiotic biosynthesis monooxygenase M478_582 ENOG4105PVA Biofilm formation regulatory protein BssS M478_583 ENOG4107QQB Ribonuclease E M478_584 ENOG4105EI2 Pseudouridine synthase M478_586 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein M478_587 ENOG4105VGS 50s ribosomal protein l32 M478_590 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase M478_591 ENOG4105CHR reductase M478_593 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) M478_594 ENOG4108RS6 transposase M478_595 ENOG4105YAZ 4-amino-4-deoxychorismate lyase M478_596 ENOG4105HHA aminodeoxychorismate lyase M478_598 ENOG4107QRG dna polymerase iii M478_599 ENOG4105F8V Hydrolase, tatD family M478_6 ENOG4105CK5 oxidoreductase M478_600 ENOG4105CI1 PTS System M478_606 ENOG4105F9E Shikimate 5-dehydrogenase M478_607 ENOG4105K59 histidine triad (HIT) protein M478_608 ENOG41090DQ Lipoprotein M478_611 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) M478_613 ENOG4105CEP NADH dehydrogenase M478_617 ENOG4107MBR 17 kDa surface antigen M478_618 ENOG4108JA2 transcriptioN-repair coupling factor M478_619 ENOG4105D60 lipoprotein releasing system transmembrane protein M478_62 ENOG41090R7 Ferric uptake M478_621 ENOG4105D60 lipoprotein releasing system transmembrane protein M478_623 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) M478_625 ENOG4105EZE Cupin 4 family protein M478_627 ENOG4105XJC Two component transcriptional regulator (Winged helix family M478_629 ENOG4107QTF adenylosuccinate lyase M478_63 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) M478_633 ENOG4108R99 pseudouridine synthase M478_634 ENOG4108HMX isocitrate dehydrogenase (NADP) M478_635 ENOG4106NDP Transcriptional regulator M478_637 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor M478_638 ENOG4105ECR NmrA family M478_639 ENOG4105KVH Transcriptional regulator M478_64 ENOG4105NNH LexA regulated protein M478_641 ENOG4105D6F Phosphatase M478_642 ENOG41061EV selenium-binding protein YdfZ M478_644 ENOG4108XM1 transcriptional regulator AsnC family M478_645 ENOG4105GSJ Inner membrane protein ylaC M478_648 ENOG4105VEQ Cold shock protein M478_650 ENOG4105C8Q Methyl-accepting chemotaxis M478_651 ENOG4105C8Q Methyl-accepting chemotaxis M478_652 ENOG4105KT7 mgtC SapB transporter M478_653 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic M478_654 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) M478_655 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region M478_656 ENOG4107RD7 Flagellar Motor Protein, MotA M478_657 ENOG4105ER2 Ompa motb domain protein M478_658 ENOG4105CBS Chea signal transduction histidine kinase M478_659 ENOG4108V3W Chemotaxis protein, CheW M478_66 ENOG4105EV9 Alpha Beta Hydrolase M478_660 ENOG4105R9B Major Facilitator M478_661 ENOG4105KME endoribonuclease L-psp M478_663 ENOG4105WWK YheO domain protein M478_668 ENOG4105C8Q Methyl-accepting chemotaxis M478_669 ENOG4105C8Q Methyl-accepting chemotaxis M478_670 ENOG4105BZU Histidine kinase M478_672 ENOG4108VYJ response regulator receiver protein M478_673 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) M478_674 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase M478_675 ENOG4105EUR Domain-Containing protein M478_676 ENOG4105EUR Domain-Containing protein M478_679 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) M478_688 ENOG4105WT8 Protein of unknown function (DUF1480) M478_69 ENOG4105DFP Integrase M478_691 ENOG4105GQR Chaperone M478_695 ENOG4105DY2 Paraquat-inducible protein b M478_696 ENOG4105H2K paraquat-inducible protein a M478_697 ENOG4108ZGC gaf domain protein M478_699 ENOG4105CN1 protease M478_7 ENOG4105EDK PfkB domain protein M478_702 ENOG4105H8W Fimbrial protein M478_703 ENOG4108VEV chaperone M478_706 ENOG4108VEV chaperone M478_707 ENOG4105C0R drug resistance transporter emrb qaca subfamily M478_708 ENOG4105CAZ oligogalacturonide lyase M478_710 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase M478_711 ENOG4108ETY sodium dicarboxylate symporter M478_712 ENOG4107K5X Membrane-bound metal-dependent hydrolase M478_713 ENOG4108PU9 oligogalacturonate-specific porin M478_714 ENOG4105WEM extracellular solute-binding protein M478_716 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component M478_717 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component M478_718 ENOG41061NF Pectate lyase M478_719 ENOG4105CHR reductase M478_721 ENOG4105M5J Cupin 2, conserved barrel domain protein M478_723 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 M478_724 ENOG4107PN8 YfeABCD locus regulator M478_725 ENOG4105FGM Fructosamine kinase M478_726 ENOG4105CC5 ABC transporter M478_727 ENOG4105CC5 ABC transporter M478_728 ENOG4105DIK (ABC) transporter M478_729 ENOG4105DSE periplasmic solute binding protein M478_73 ENOG4105GIJ Glycine betaine M478_733 ENOG41087WU M478_738 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) M478_739 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) M478_74 ENOG4108HQS Glycine betaine M478_740 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) M478_743 ENOG4108V06 Glutathione peroxidase M478_744 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) M478_75 ENOG4108IJ7 Glycine betaine M478_752 ENOG4108QBX (LipO)protein M478_756 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) M478_758 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) M478_759 ENOG4105IPI Membrane M478_76 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M478_760 ENOG4105CQB FAD linked oxidase domain protein M478_761 ENOG4105KA0 thioesterase Superfamily protein M478_762 ENOG4108Z4V iron-sulfur cluster assembly M478_763 ENOG4105DIW FeS assembly protein SUFB M478_764 ENOG4105C3K feS assembly ATPase SufC M478_765 ENOG4105JRK feS assembly protein SufD M478_768 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein M478_774 ENOG4105KMX major outer membrane lipoprotein M478_775 ENOG4105CA9 Pyruvate kinase M478_779 ENOG4108R6K riboflavin synthase, subunit alpha M478_780 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase M478_781 ENOG4105CZQ inner membrane transport protein YdhC M478_782 ENOG4105F52 Transcriptional regulator M478_785 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) M478_786 ENOG4105K4H Nlp p60 protein M478_788 ENOG4105M2J Glutaredoxin M478_789 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) M478_790 ENOG4108UYE Lactoylglutathione lyase M478_791 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase M478_792 ENOG4108WUH Transcriptional regulator, TetR family M478_793 ENOG4105DIJ Phosphoethanolamine transferase M478_795 ENOG4108XTF Outer Membrane Lipoprotein M478_797 ENOG410642K Lysozyme inhibitor M478_801 ENOG4108K3A Glutathione S-transferase M478_802 ENOG4108ZR5 Conserved Protein M478_803 ENOG41069YE inner membrane protein yohC M478_804 ENOG4105DUX Transporter M478_806 ENOG4105Q4T oxidoreductase M478_807 ENOG4108JQ2 peptide transport system atp-binding protein M478_808 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein M478_809 ENOG4108EU3 peptide transport system, permease M478_81 ENOG4108WMJ Protein of unknown function (DUF2002) M478_810 ENOG4108I5W peptide transport system, permease protein M478_811 ENOG4108HIY periplasmic M478_812 ENOG4108RS6 transposase M478_813 ENOG4105E51 psp operon transcriptional activator M478_814 ENOG41087YS Phage shock protein A M478_815 ENOG4105YYT phage shock protein B M478_816 ENOG4105FM1 phage shock protein C M478_818 ENOG4105CM6 amino acid regulated cytosolic protein M478_82 ENOG4108SAJ Protein of unknown function (DUF1198) M478_824 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) M478_825 ENOG4107S8C mandelate racemase muconate lactonizing M478_826 ENOG4105KXI murein peptide amidase A M478_827 ENOG4107QSI ABC, transporter M478_833 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) M478_835 ENOG4105KT7 mgtC SapB transporter M478_837 ENOG41090X5 Heat shock protein hslJ M478_838 ENOG4105C5I Dehydrogenase M478_839 ENOG4107H52 Dicarboxylate transport M478_84 ENOG4105VEQ Cold shock protein M478_840 ENOG410689M (LipO)protein M478_841 ENOG4105WXT Conserved Protein M478_842 ENOG4105DEI Mannitol dehydrogenase M478_843 ENOG4105DKT Transcriptional regulator M478_845 ENOG4105CQ7 ATP-dependent helicase M478_848 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap M478_85 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein M478_850 ENOG4105DS1 cytochrome b561 M478_856 ENOG4108EKI Dehydrogenase M478_857 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein M478_858 ENOG4107QSI ABC, transporter M478_86 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M478_860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M478_861 ENOG4105C3U ABC transporter M478_862 ENOG4108JQ7 (ABC) transporter M478_866 ENOG4108T1M outer membrane protein x M478_869 ENOG4105K9H YciI-like protein M478_87 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M478_871 ENOG410822N TonB family M478_873 ENOG4105NAU thioesterase Superfamily protein M478_878 ENOG4105EIF outer membrane protein W M478_88 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) M478_882 ENOG4105DK0 Indole-3-glycerol phosphate synthase M478_884 ENOG4105DDQ anthranilate synthase M478_886 ENOG4105DB7 PHP domain protein M478_887 ENOG4107RTD sua5 ycio yrdc ywlc family protein M478_888 ENOG4105FE9 pseudouridine synthase M478_889 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase M478_89 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) M478_890 ENOG4105UBK short-chain dehydrogenase reductase M478_891 ENOG4105ERU peptidase M478_892 ENOG4105RKX Protein of unknown function (DUF2498) M478_894 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) M478_895 ENOG4107R11 Transcriptional regulator M478_897 ENOG4107QM5 aconitate hydratase M478_898 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) M478_899 ENOG4105EYK Phosphatidylglycerophosphatase B M478_9 ENOG4105DH8 myo-inositol catabolism M478_900 ENOG4105Q4A inner membrane protein yciS M478_901 ENOG4105CFV Tetratricopeptide repeat protein M478_904 ENOG4108ZJT translation initiation factor, Sui1 M478_905 ENOG41061RM osmotically inducible lipoprotein M478_906 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase M478_908 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) M478_909 ENOG4105VCD cytoplasmic protein M478_910 ENOG4105D22 carbon starvation protein M478_912 ENOG4105CSP Major Facilitator Superfamily M478_913 ENOG4105EXW epimerase dehydratase M478_914 ENOG4105CSM endonuclease III M478_916 ENOG4108UQQ Electron transport complex M478_917 ENOG4105D6A Electron transport complex M478_918 ENOG4105UEI Transcriptional Regulator AraC Family M478_922 ENOG4105M9B inner membrane protein ydgK M478_923 ENOG4108JJA ABC, transporter M478_925 ENOG4105C42 Type I secretion membrane fusion protein (HlyD M478_926 ENOG4108JJA ABC, transporter M478_930 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator M478_932 ENOG4105CNN ABC, transporter M478_934 ENOG4105D9R oxidoreductase M478_935 ENOG4105DHU Bile acid M478_937 ENOG4106J39 exported protein M478_938 ENOG4105EIP mannose-6-phosphate isomerase M478_939 ENOG4105C9Q fumarate hydratase class II M478_940 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) M478_941 ENOG4105D94 Major Facilitator Superfamily M478_942 ENOG4106NZI LysR family Transcriptional regulator M478_943 ENOG4105DAG ROK family M478_945 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) M478_946 ENOG4105CMQ Chloride channel M478_947 ENOG41060NJ transcriptional regulator M478_949 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M478_950 ENOG4107UWC ABC, transporter M478_951 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component M478_953 ENOG4105FYV Amp nucleosidase M478_958 ENOG4105C7K acetolactate synthase M478_959 ENOG4105M71 acetolactate synthase 1 regulatory subunit M478_96 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) M478_960 ENOG4105PAD Hydrolase M478_963 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) M478_964 ENOG4105DS0 Transcriptional regulator, Crp Fnr family M478_965 ENOG4105Q9Y Universal stress protein M478_966 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) M478_967 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) M478_968 ENOG4105C5D exported protein M478_969 ENOG4105D5Q Arginine ornithine antiporter M478_971 ENOG4107EXC regulatoR M478_972 ENOG4105JJR Histidine kinase M478_973 ENOG4105CTD carboxy-peptidase M478_974 ENOG4108RS6 transposase M478_980 ENOG4107104 thymidine kinase M478_982 ENOG4105C6Y Udp-glucose 6-dehydrogenase M478_983 ENOG4105I93 response regulator M478_986 ENOG4105CIY formyltetrahydrofolate deformylase M478_990 ENOG4105SKE transcriptional Regulator LysR family M478_991 ENOG4105CGK Exodeoxyribonuclease III M478_992 ENOG4105M6F mutator MutT protein M478_993 ENOG4105MTM Protein of unknown function (DUF1496) M478_994 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) M478_995 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) M478_996 ENOG41069NU Nitroreductase M478_997 ENOG4105D07 Signal peptide peptidase, SppA M478_998 ENOG4105HDK L-asparaginase M478_999 ENOG4108RWI nicotinamidase