locus-tag	class	description
M478_1	COG0673	inositol 2-dehydrogenase activity
M478_1000	COG3139	Protein of unknown function (DUF1315)
M478_1004	COG3713	MltA-interacting MipA family protein
M478_1005	COG2766	serine protein kinase
M478_1008	COG0583	DNA-binding transcription factor activity
M478_101	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M478_1010	COG2814	Major facilitator Superfamily
M478_1012	COG2719	SpoVR family
M478_1018	COG1104	cysteine desulfurase activity
M478_102	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M478_1020	COG3328	transposase activity
M478_1021	COG3328	transposase activity
M478_103	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M478_104	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M478_105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M478_1052	COG3328	transposase activity
M478_106	COG1447	Phosphotransferase system cellobiose-specific component IIA
M478_107	COG1917	Cupin 2, conserved barrel domain protein
M478_107	COG2169	Transcriptional regulator
M478_1072	COG0582	viral genome integration into host DNA
M478_1074	COG0179	Fumarylacetoacetate (FAA) hydrolase
M478_1075	COG2951	lytic endotransglycosylase activity
M478_1078	COG2894	cell division
M478_1079	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M478_1080	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M478_1081	COG0318	PFAM AMP-dependent synthetase and ligase
M478_1082	COG3065	identical protein binding
M478_1084	COG1199	ATP-dependent helicase activity
M478_1085	COG0251	oxidation-reduction process
M478_1088	COG0800	Aldolase
M478_1090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M478_1091	COG1737	Transcriptional regulator
M478_1092	COG0469	pyruvate kinase activity
M478_1093	COG1560	Kdo2-lipid A biosynthetic process
M478_1094	COG0739	heme binding
M478_1095	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M478_1097	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M478_11	COG5265	(ABC) transporter
M478_1102	COG0494	nUDIX hydrolase
M478_1104	COG1801	Protein of unknown function DUF72
M478_1105	COG3788	relative of glutathione S-transferase, MAPEG superfamily
M478_1109	COG3102	Protein conserved in bacteria
M478_111	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M478_1113	COG0728	peptidoglycan biosynthetic process
M478_1114	COG0673	inositol 2-dehydrogenase activity
M478_1115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M478_1118	COG3381	protein complex oligomerization
M478_112	COG0033	Phosphoglucomutase
M478_1121	COG1940	carbohydrate kinase activity
M478_1122	COG0584	glycerophosphoryl diester phosphodiesterase
M478_1123	COG3842	ATPase activity
M478_1124	COG1943	Transposase
M478_1126	COG1176	ABC-type spermidine putrescine transport system, permease component I
M478_1127	COG3833	ABC-type maltose transport systems, permease component
M478_1132	COG0659	secondary active sulfate transmembrane transporter activity
M478_1134	COG2912	Transglutaminase-like superfamily
M478_1135	COG3094	Invasion gene expression up-regulator, SirB
M478_1136	COG2890	protein-(glutamine-N5) methyltransferase activity
M478_1141	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M478_1144	COG0012	GTP binding
M478_1155	COG5002	protein histidine kinase activity
M478_116	COG0745	RESPONSE REGULATOR receiver
M478_1164	COG0500	methyltransferase
M478_1169	COG3328	transposase activity
M478_117	COG2205	protein histidine kinase activity
M478_1178	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M478_1179	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M478_1180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M478_1183	COG0402	S-adenosylhomocysteine deaminase activity
M478_1193	COG0395	ABC-type sugar transport system, permease component
M478_1194	COG1175	transmembrane transport
M478_1196	COG0673	inositol 2-dehydrogenase activity
M478_1203	COG3328	transposase activity
M478_1204	COG3328	transposase activity
M478_122	COG3272	Protein of unknown function (DUF1722)
M478_1227	COG2197	response regulator
M478_1229	COG3136	membrane protein required for alginate biosynthesis
M478_1233	COG1113	amino acid transport
M478_1236	COG2837	iron assimilation
M478_124	COG5212	phosphodiesterase
M478_1241	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M478_1241	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M478_1241	COG0506	proline dehydrogenase activity
M478_1247	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M478_1249	COG1191	sigma factor activity
M478_125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M478_1255	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M478_1256	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M478_1257	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M478_1260	COG1677	Flagellar hook-basal body complex protein FliE
M478_1262	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M478_1264	COG1157	protein secretion by the type III secretion system
M478_1265	COG2882	bacterial-type flagellum organization
M478_1267	COG1580	Controls the rotational direction of flagella during chemotaxis
M478_127	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M478_1272	COG1987	bacterial-type flagellum assembly
M478_1276	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M478_1277	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_1278	COG1129	ABC transporter
M478_128	COG1984	allophanate hydrolase subunit 2
M478_1280	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_1281	COG1028	Short-chain dehydrogenase reductase Sdr
M478_1281	COG3347	Dehydrogenase
M478_1282	COG2390	Transcriptional regulator
M478_1284	COG1256	bacterial-type flagellum assembly
M478_1288	COG4786	Flagellar basal body rod
M478_1290	COG1749	Flagellar hook protein flgE
M478_1291	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M478_1292	COG1558	bacterial-type flagellum-dependent cell motility
M478_1293	COG1815	bacterial-type flagellum-dependent cell motility
M478_1295	COG2747	anti-sigma28 factor FlgM
M478_1296	COG3418	PFAM FlgN family protein
M478_1298	COG1943	Transposase
M478_1301	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M478_1302	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M478_1307	COG2372	response to copper ion
M478_1308	COG1528	Iron-storage protein
M478_1311	COG1770	oligopeptidase
M478_1314	COG3141	response to X-ray
M478_1315	COG0513	Belongs to the DEAD box helicase family
M478_1320	COG1760	l-serine dehydratase
M478_1321	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M478_1322	COG2368	4-hydroxyphenylacetate
M478_1325	COG3971	2-oxopent-4-enoate hydratase activity
M478_1327	COG3384	dioxygenase
M478_1328	COG1012	belongs to the aldehyde dehydrogenase family
M478_1331	COG1846	Transcriptional regulator
M478_1334	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M478_1334	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_1335	COG3715	PTS system
M478_1336	COG3716	PTS system mannose fructose sorbose family IID component
M478_1341	COG3447	MASE1 domain protein
M478_1341	COG5002	protein histidine kinase activity
M478_1341	COG5001	Diguanylate cyclase
M478_1343	COG2226	methyltransferase
M478_1345	COG1278	Cold shock
M478_1348	COG1113	amino acid transport
M478_1355	COG2207	Transcriptional regulator
M478_1357	COG1132	(ABC) transporter
M478_1367	COG3328	transposase activity
M478_1368	COG2223	nitrite transmembrane transporter activity
M478_1373	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M478_1378	COG3122	Protein conserved in bacteria
M478_1382	COG0534	Mate efflux family protein
M478_1386	COG4948	Mandelate Racemase Muconate Lactonizing
M478_1388	COG1028	Short-chain dehydrogenase reductase Sdr
M478_1389	COG3011	Protein conserved in bacteria
M478_1390	COG2271	Major facilitator Superfamily
M478_1391	COG3328	transposase activity
M478_1392	COG1388	LysM domain
M478_1392	COG1470	cell adhesion involved in biofilm formation
M478_1395	COG2925	Exonuclease
M478_1396	COG0531	amino acid
M478_1398	COG0371	Dehydrogenase
M478_1399	COG1129	ABC transporter
M478_140	COG0513	Belongs to the DEAD box helicase family
M478_1400	COG1129	ABC transporter
M478_1401	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_1403	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M478_1405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M478_1407	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M478_1407	COG0131	Imidazoleglycerol-phosphate dehydratase
M478_1408	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M478_1411	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M478_1411	COG0140	phosphoribosyl-ATP diphosphatase activity
M478_1413	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M478_1414	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M478_1418	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M478_1419	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M478_142	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M478_1420	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M478_1421	COG1120	ATPase activity
M478_1424	COG3486	L-lysine 6-monooxygenase (NADPH) activity
M478_1425	COG0076	glutamate decarboxylase activity
M478_1426	COG4114	ferric iron reductase
M478_1427	COG1253	flavin adenine dinucleotide binding
M478_1428	COG2982	Protein involved in outer membrane biogenesis
M478_1431	COG0489	protein tyrosine kinase activity
M478_1433	COG1943	Transposase
M478_1437	COG2814	Major facilitator Superfamily
M478_1439	COG1346	cytolysis
M478_144	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
M478_1442	COG2949	membrane
M478_1443	COG4211	Belongs to the binding-protein-dependent transport system permease family
M478_1446	COG2311	Membrane
M478_1448	COG0477	Major facilitator Superfamily
M478_1449	COG0583	DNA-binding transcription factor activity
M478_145	COG3026	antisigma factor binding
M478_1455	COG1136	(ABC) transporter
M478_1457	COG0303	'Molybdopterin
M478_1459	COG3328	transposase activity
M478_146	COG3086	response to oxidative stress
M478_1461	COG0488	(ABC) transporter
M478_1489	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M478_149	COG0681	Belongs to the peptidase S26 family
M478_1490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M478_1492	COG1028	Short-chain dehydrogenase reductase Sdr
M478_1493	COG1024	Enoyl-CoA hydratase
M478_1495	COG3425	synthase
M478_1496	COG1028	Short-chain dehydrogenase reductase Sdr
M478_1497	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M478_1498	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M478_1500	COG1028	Short-chain dehydrogenase reductase Sdr
M478_1507	COG2920	part of a sulfur-relay system
M478_1511	COG1832	CoA-binding protein
M478_1512	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M478_1514	COG0210	DNA helicase
M478_1515	COG3304	Inner membrane component domain
M478_1516	COG1289	transmembrane transporter activity
M478_1517	COG3070	regulator of competence-specific genes
M478_1519	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M478_1519	COG2885	chlorophyll binding
M478_1520	COG1943	Transposase
M478_1522	COG1067	ATP-dependent peptidase activity
M478_1525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M478_1528	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M478_1529	COG1943	Transposase
M478_153	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M478_1530	COG3009	Protein conserved in bacteria
M478_1531	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M478_1531	COG3008	intermembrane lipid transfer
M478_1532	COG2995	paraquat-inducible protein a
M478_1533	COG0488	(ABC) transporter
M478_1535	COG3217	Mosc domain protein beta barrel domain protein
M478_1535	COG0633	Ferredoxin
M478_1538	COG0308	aminopeptidase N
M478_1542	COG1448	Aminotransferase
M478_1543	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M478_1544	COG3108	Peptidase M15
M478_1545	COG2989	Protein conserved in bacteria
M478_1546	COG1943	Transposase
M478_1548	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M478_1549	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
M478_155	COG1943	Transposase
M478_1550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M478_1551	COG3173	Aminoglycoside phosphotransferase
M478_1553	COG2835	tetraacyldisaccharide 4'-kinase activity
M478_1554	COG1278	Cold shock
M478_1555	COG5383	Protein conserved in bacteria
M478_1558	COG0658	competence protein
M478_1558	COG2333	competence protein COMEC
M478_156	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M478_1561	COG0539	negative regulation of cytoplasmic translation
M478_1566	COG5295	Hep Hag repeat protein
M478_1566	COG5295	Hep Hag repeat protein
M478_1567	COG0252	asparaginase activity
M478_1568	COG1944	ATP diphosphatase activity
M478_1569	COG2116	formate transmembrane transporter activity
M478_157	COG1737	Transcriptional regulator
M478_1570	COG1882	Formate acetyltransferase
M478_1572	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M478_1573	COG2814	Major facilitator Superfamily
M478_1576	COG2814	Major facilitator Superfamily
M478_1578	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M478_1581	COG3107	peptidoglycan biosynthetic process
M478_1581	COG1674	ftsk spoiiie
M478_1583	COG0492	ferredoxin-NADP+ reductase activity
M478_1585	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M478_1587	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M478_1588	COG1943	Transposase
M478_1589	COG0542	response to heat
M478_159	COG0560	Phosphoserine phosphatase
M478_1591	COG1278	Cold shock
M478_1593	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M478_1594	COG2990	Protein conserved in bacteria
M478_1595	COG3593	DNA synthesis involved in DNA repair
M478_1596	COG2431	L-lysine efflux transmembrane transporter activity
M478_1598	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M478_1599	COG0028	Belongs to the TPP enzyme family
M478_16	COG2197	response regulator
M478_160	COG0590	tRNA wobble adenosine to inosine editing
M478_1600	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M478_1601	COG0702	epimerase
M478_1602	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M478_1604	COG1605	Chorismate mutase
M478_1605	COG1126	abc transporter atp-binding protein
M478_1606	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_1607	COG4215	(ABC) transporter
M478_1608	COG4160	amino acid transport
M478_1612	COG1120	ATPase activity
M478_1613	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M478_1618	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_1621	COG1177	transmembrane transport
M478_1622	COG1176	ABC-type spermidine putrescine transport system, permease component I
M478_1623	COG3842	ATPase activity
M478_1624	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M478_1627	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M478_1628	COG0569	domain protein
M478_1628	COG2985	domain, Protein
M478_1630	COG0671	phosphoesterase, PA-phosphatase related
M478_1631	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M478_1632	COG1349	DNA-binding transcription factor activity
M478_1633	COG0814	amino acid
M478_1634	COG1686	Belongs to the peptidase S11 family
M478_1635	COG2011	ABC-type metal ion transport system permease component
M478_1641	COG0625	glutathione transferase activity
M478_1642	COG4771	TonB-dependent receptor
M478_1644	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M478_1646	COG0833	amino acid
M478_1648	COG0583	DNA-binding transcription factor activity
M478_1649	COG2855	membrane
M478_1651	COG3188	usher protein
M478_1652	COG3121	Chaperone
M478_1655	COG3710	Transcriptional regulator
M478_1656	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M478_1656	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M478_1656	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M478_1657	COG1105	Belongs to the carbohydrate kinase PfkB family
M478_1659	COG0494	nUDIX hydrolase
M478_166	COG1943	Transposase
M478_1660	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_1661	COG1129	ABC transporter
M478_1663	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M478_1668	COG1028	Short-chain dehydrogenase reductase Sdr
M478_167	COG2205	protein histidine kinase activity
M478_1672	COG1312	Catalyzes the dehydration of D-mannonate
M478_1673	COG0246	Mannitol dehydrogenase
M478_1674	COG2186	Transcriptional regulator
M478_1676	COG0523	cobalamin synthesis protein
M478_1677	COG0671	phosphoesterase, PA-phosphatase related
M478_1678	COG0791	NLP P60 protein
M478_168	COG3170	Tfp pilus assembly protein FimV
M478_1680	COG2200	EAL domain
M478_1681	COG4166	transmembrane transport
M478_1682	COG4174	ABC transporter (Permease)
M478_1683	COG4239	(ABC) transporter, permease
M478_1684	COG4172	Belongs to the ABC transporter superfamily
M478_1686	COG2814	Major facilitator Superfamily
M478_1687	COG1187	pseudouridine synthase activity
M478_1688	COG1061	Type III restriction enzyme res subunit
M478_169	COG2204	response regulator
M478_1690	COG1943	Transposase
M478_1692	COG3082	Protein of unknown function (DUF1414)
M478_1693	COG3083	sulfuric ester hydrolase activity
M478_1696	COG3157	Type VI secretion system effector, Hcp
M478_17	COG1278	Cold shock
M478_170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M478_170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M478_1700	COG2723	6-phospho-beta-galactosidase activity
M478_1702	COG1737	Transcriptional regulator
M478_1706	COG3299	homolog of phage Mu protein gp47
M478_171	COG0347	Belongs to the P(II) protein family
M478_1714	COG4386	tail sheath protein
M478_1718	COG3622	Belongs to the hyi family
M478_1719	COG1349	DNA-binding transcription factor activity
M478_172	COG2188	Transcriptional regulator
M478_1720	COG0235	Class ii aldolase
M478_1721	COG3395	kinase activity
M478_1729	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M478_173	COG2188	Transcriptional regulator
M478_1732	COG1943	Transposase
M478_1733	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M478_1735	COG2223	nitrite transmembrane transporter activity
M478_1736	COG0642	Histidine kinase
M478_1736	COG2198	Histidine kinase
M478_1737	COG2198	Histidine kinase
M478_1737	COG0642	Histidine kinase
M478_1739	COG2205	protein histidine kinase activity
M478_1739	COG0784	Response regulator, receiver
M478_1744	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M478_1747	COG0814	amino acid
M478_1752	COG0697	spore germination
M478_1754	COG1982	Orn Lys Arg decarboxylase major
M478_1755	COG0531	amino acid
M478_1756	COG1174	glycine betaine transport
M478_1757	COG1125	glycine betaine transport
M478_1758	COG1174	glycine betaine transport
M478_176	COG1017	nitric oxide dioxygenase activity
M478_176	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M478_1761	COG2897	thiosulfate sulfurtransferase activity
M478_1764	COG0410	ABC transporter
M478_1765	COG1122	ATPase activity
M478_1769	COG4807	Protein conserved in bacteria
M478_1772	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
M478_1774	COG2261	transglycosylase associated protein
M478_1776	COG1403	HNH endonuclease
M478_1778	COG0277	FAD linked oxidase domain protein
M478_1779	COG1686	Belongs to the peptidase S11 family
M478_1781	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M478_1783	COG1943	Transposase
M478_1784	COG0670	Belongs to the BI1 family
M478_1785	COG0314	molybdopterin synthase activity
M478_1786	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M478_1788	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M478_179	COG3711	transcriptional antiterminator
M478_1790	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M478_1791	COG4628	conserved protein (DUF2132)
M478_1792	COG0556	nucleotide-excision repair
M478_1794	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M478_1795	COG2226	methyltransferase
M478_18	COG1278	Cold shock
M478_180	COG2814	Major facilitator Superfamily
M478_1800	COG0561	phosphatase activity
M478_1802	COG4149	molybdate abc transporter
M478_1803	COG0725	ABC transporter, periplasmic molybdate-binding protein
M478_1805	COG2005	Transcriptional regulator
M478_1805	COG3585	molybdate ion transport
M478_1806	COG1119	ATPase activity
M478_1809	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M478_181	COG3683	transport system, periplasmic component
M478_1810	COG1085	galactose-1-phosphate uridylyltransferase
M478_1813	COG2017	converts alpha-aldose to the beta-anomer
M478_1816	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M478_1818	COG1230	cation diffusion facilitator family transporter
M478_182	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
M478_1824	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M478_1825	COG2885	chlorophyll binding
M478_1827	COG3064	Membrane
M478_1827	COG3064	Membrane
M478_1828	COG0848	biopolymer transport protein
M478_1829	COG0811	peptide transport
M478_183	COG0483	inositol monophosphate 1-phosphatase activity
M478_1830	COG0824	Thioesterase
M478_1831	COG3790	cyd operon protein YbgE
M478_1832	COG4890	Cyd operon protein YbgT
M478_1833	COG1294	oxidase, subunit
M478_1834	COG1271	oxidase subunit
M478_1835	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M478_1837	COG0508	dehydrogenase complex catalyzes the overall conversion of
M478_1838	COG0567	Dehydrogenase, E1 component
M478_1840	COG1053	succinate dehydrogenase
M478_1841	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M478_1842	COG2009	succinate dehydrogenase
M478_1845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M478_1846	COG0497	DNA recombination
M478_1847	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M478_1849	COG2867	negative regulation of translational initiation
M478_1851	COG1943	Transposase
M478_1852	COG0582	viral genome integration into host DNA
M478_186	COG1104	cysteine desulfurase activity
M478_1862	COG3657	addiction module killer protein
M478_1868	COG1953	Uracil, thiamine, allantoin
M478_187	COG0822	iron-sulfur transferase activity
M478_1870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M478_1872	COG2226	methyltransferase
M478_1874	COG0741	lytic transglycosylase activity
M478_1874	COG1388	LysM domain
M478_1877	COG0656	L-ascorbic acid biosynthetic process
M478_1883	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M478_1885	COG2011	ABC-type metal ion transport system permease component
M478_1886	COG1464	Belongs to the NlpA lipoprotein family
M478_1888	COG1720	tRNA m6t6A37 methyltransferase activity
M478_1890	COG3015	lipoprotein NlpE involved in copper resistance
M478_1892	COG4681	YaeQ
M478_1894	COG4568	rho-dependent transcription termination
M478_1896	COG0037	tRNA processing
M478_1897	COG0346	lactoylglutathione lyase activity
M478_1899	COG0587	DNA-directed DNA polymerase activity
M478_19	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M478_1901	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M478_1905	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M478_1907	COG0750	zinc metalloprotease
M478_1908	COG0575	Belongs to the CDS family
M478_1909	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M478_191	COG0633	Ferredoxin
M478_1915	COG0024	Methionine aminopeptidase
M478_192	COG2975	iron-sulfur cluster assembly
M478_1920	COG0564	pseudouridine synthase activity
M478_1921	COG3098	single-species biofilm formation
M478_1922	COG1943	Transposase
M478_1925	COG1611	Belongs to the LOG family
M478_1929	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M478_1931	COG2363	Small membrane protein
M478_1932	COG0583	DNA-binding transcription factor activity
M478_1934	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M478_1935	COG2166	iron-sulfur cluster assembly
M478_1936	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M478_1937	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M478_1940	COG0860	N-Acetylmuramoyl-L-alanine amidase
M478_1942	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M478_1943	COG1074	ATP-dependent DNA helicase activity
M478_1945	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M478_1956	COG0667	Aldo Keto reductase
M478_196	COG3468	outer membrane autotransporter barrel domain protein
M478_1962	COG0019	diaminopimelate decarboxylase activity
M478_1963	COG1609	Transcriptional regulator
M478_1964	COG2814	Major facilitator Superfamily
M478_1965	COG0583	DNA-binding transcription factor activity
M478_1966	COG0583	DNA-binding transcription factor activity
M478_1968	COG0840	transmembrane signaling receptor activity
M478_197	COG3468	outer membrane autotransporter barrel domain protein
M478_1987	COG0288	reversible hydration of carbon dioxide
M478_1995	COG4771	TonB-dependent receptor
M478_1996	COG2195	Cleaves the N-terminal amino acid of tripeptides
M478_1997	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M478_2	COG0673	inositol 2-dehydrogenase activity
M478_20	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M478_2005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M478_2007	COG5001	Diguanylate cyclase
M478_2007	COG3300	MHYT domain
M478_2008	COG2801	Transposase and inactivated derivatives
M478_2010	COG2211	Major facilitator Superfamily
M478_2020	COG3916	Acyl-homoserine-lactone synthase
M478_2021	COG2771	luxR family
M478_2038	COG1662	PFAM IS1 transposase
M478_2043	COG1662	PFAM IS1 transposase
M478_2047	COG1982	Orn Lys Arg decarboxylase major
M478_2048	COG1879	ABC-type sugar transport system periplasmic component
M478_2049	COG1129	ABC transporter
M478_205	COG2976	Protein conserved in bacteria
M478_2050	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_2051	COG4774	siderophore transport
M478_2055	COG1194	a g-specific adenine glycosylase
M478_2057	COG3171	Protein conserved in bacteria
M478_2058	COG2066	Belongs to the glutaminase family
M478_206	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M478_2061	COG1073	alpha beta
M478_2061	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M478_2061	COG3064	Membrane
M478_2062	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M478_2063	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M478_2065	COG0762	integral membrane protein
M478_2066	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M478_2067	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M478_2068	COG2805	Type II/IV secretion system protein
M478_2070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M478_2073	COG0189	ligase activity
M478_2074	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M478_2075	COG2356	endonuclease I
M478_2079	COG1166	arginine decarboxylase activity
M478_2081	COG0501	Belongs to the peptidase M48B family
M478_2082	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M478_2086	COG0191	fructose-bisphosphate aldolase activity
M478_209	COG1645	bacterial-type flagellum-dependent swarming motility
M478_2091	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M478_2092	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M478_2093	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M478_2096	COG0006	proline dipeptidase activity
M478_2097	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M478_2098	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M478_2104	COG5295	Hep Hag repeat protein
M478_2106	COG1272	protein, Hemolysin III
M478_211	COG0517	IMP dehydrogenase activity
M478_211	COG0516	GMP reductase activity
M478_2113	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M478_2114	COG0745	RESPONSE REGULATOR receiver
M478_2115	COG2205	protein histidine kinase activity
M478_2116	COG4452	Inner membrane protein CreD
M478_2117	COG0716	FMN binding
M478_2118	COG4974	Belongs to the 'phage' integrase family
M478_2119	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M478_2120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M478_2124	COG0582	viral genome integration into host DNA
M478_2129	COG2944	sequence-specific DNA binding
M478_213	COG1943	Transposase
M478_2146	COG1695	Transcriptional regulator
M478_2147	COG0791	NLP P60 protein
M478_2149	COG1879	ABC-type sugar transport system periplasmic component
M478_2150	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_2151	COG1129	ABC transporter
M478_2153	COG2182	Extracellular solute-binding protein
M478_2154	COG1175	transmembrane transport
M478_2155	COG3833	ABC-type maltose transport systems, permease component
M478_2156	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M478_2157	COG1874	Beta-galactosidase
M478_2158	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M478_2158	COG1263	PTS System
M478_2162	COG2271	Major facilitator Superfamily
M478_2166	COG0191	fructose-bisphosphate aldolase activity
M478_2168	COG3119	arylsulfatase activity
M478_2169	COG0641	radical SAM
M478_2171	COG1028	Short-chain dehydrogenase reductase Sdr
M478_2173	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_2174	COG3716	PTS system mannose fructose sorbose family IID component
M478_2175	COG3715	PTS system
M478_2176	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M478_2177	COG2222	sugar isomerase
M478_2179	COG1349	DNA-binding transcription factor activity
M478_2180	COG3119	arylsulfatase activity
M478_2186	COG2226	methyltransferase
M478_2186	COG3433	isochorismatase activity
M478_2186	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M478_2187	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M478_2188	COG3433	isochorismatase activity
M478_2188	COG2226	methyltransferase
M478_2188	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M478_2194	COG1132	(ABC) transporter
M478_2198	COG2610	gluconate transmembrane transporter activity
M478_220	COG3328	transposase activity
M478_2204	COG3501	Rhs element vgr protein
M478_2206	COG3209	COG3209 Rhs family protein
M478_2209	COG0471	metal ion transport
M478_2211	COG2801	Transposase and inactivated derivatives
M478_2215	COG3710	Transcriptional regulator
M478_2219	COG1256	bacterial-type flagellum assembly
M478_2221	COG1706	bacterial-type flagellum-dependent cell motility
M478_2222	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M478_2223	COG4786	Flagellar basal body rod
M478_2224	COG4787	bacterial-type flagellum-dependent cell motility
M478_2225	COG1749	Flagellar hook protein flgE
M478_2226	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M478_2227	COG1558	bacterial-type flagellum-dependent cell motility
M478_2228	COG1815	bacterial-type flagellum-dependent cell motility
M478_2229	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
M478_223	COG0351	phosphomethylpyrimidine kinase
M478_2238	COG2204	response regulator
M478_2242	COG1987	bacterial-type flagellum assembly
M478_2243	COG1684	flagellar biosynthetic protein fliR
M478_2244	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M478_2249	COG4592	Periplasmic binding protein
M478_2253	COG1943	Transposase
M478_2256	COG4964	Belongs to the GSP D family
M478_2257	COG4964	Belongs to the GSP D family
M478_2267	COG0848	biopolymer transport protein
M478_2269	COG0811	peptide transport
M478_2270	COG0626	cystathionine gamma-synthase activity
M478_2271	COG0586	Pfam SNARE associated Golgi protein
M478_2272	COG2207	Transcriptional regulator
M478_2273	COG1979	alcohol dehydrogenase
M478_2274	COG0656	L-ascorbic acid biosynthetic process
M478_2277	COG2132	Multicopper oxidase
M478_2278	COG0204	Acyl-transferase
M478_2279	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M478_2280	COG2249	NAD(P)H dehydrogenase (quinone) activity
M478_2281	COG0583	DNA-binding transcription factor activity
M478_2282	COG0187	DNA topoisomerase II activity
M478_2283	COG3150	esterase
M478_2284	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M478_2285	COG3151	Protein conserved in bacteria
M478_2286	COG0494	nUDIX hydrolase
M478_2287	COG1538	Outer membrane efflux protein
M478_229	COG3422	double-strand break repair
M478_2290	COG0754	glutathionylspermidine amidase activity
M478_2291	COG3384	dioxygenase
M478_2295	COG0531	amino acid
M478_2298	COG3025	triphosphatase activity
M478_2299	COG4991	sh3 domain protein
M478_230	COG0745	RESPONSE REGULATOR receiver
M478_2302	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M478_2306	COG0358	DNA primase activity
M478_2307	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M478_231	COG2205	protein histidine kinase activity
M478_2322	COG0251	oxidation-reduction process
M478_2330	COG1289	transmembrane transporter activity
M478_2334	COG0395	ABC-type sugar transport system, permease component
M478_2336	COG1653	transport
M478_2337	COG1609	Transcriptional regulator
M478_2338	COG3459	Glycosyltransferase 36 associated
M478_2339	COG3842	ATPase activity
M478_2344	COG3210	domain, Protein
M478_2346	COG3210	domain, Protein
M478_2348	COG3210	domain, Protein
M478_2349	COG2831	hemolysin activation secretion protein
M478_2350	COG4245	von Willebrand factor, type A
M478_2353	COG4245	von Willebrand factor, type A
M478_2356	COG3247	response to pH
M478_2357	COG0446	pyridine nucleotide-disulphide oxidoreductase
M478_2357	COG1902	pentaerythritol trinitrate reductase activity
M478_236	COG3842	ATPase activity
M478_2360	COG1451	nucleotide metabolic process
M478_2361	COG0673	inositol 2-dehydrogenase activity
M478_2364	COG1943	Transposase
M478_2366	COG2721	sulfolactate sulfo-lyase activity
M478_2367	COG0246	Mannitol dehydrogenase
M478_2369	COG2271	Major facilitator Superfamily
M478_2372	COG0586	Pfam SNARE associated Golgi protein
M478_2375	COG4575	ribosome binding
M478_2376	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
M478_2378	COG2259	Doxx family
M478_2379	COG0435	Glutathione S-transferase
M478_238	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M478_2382	COG0494	nUDIX hydrolase
M478_2387	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M478_2388	COG0849	cell division
M478_2389	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M478_2393	COG0772	Belongs to the SEDS family
M478_2396	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M478_2397	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M478_2398	COG0768	penicillin binding
M478_2399	COG3116	cell division
M478_24	COG1686	Belongs to the peptidase S11 family
M478_240	COG1176	ABC-type spermidine putrescine transport system, permease component I
M478_2403	COG1609	Transcriptional regulator
M478_2404	COG1943	Transposase
M478_2406	COG0028	Belongs to the TPP enzyme family
M478_2407	COG1022	Amp-dependent synthetase and ligase
M478_241	COG1177	transmembrane transport
M478_2410	COG1943	Transposase
M478_2414	COG0505	Belongs to the CarA family
M478_2415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M478_2416	COG1280	lysine exporter protein (LysE YggA)
M478_2417	COG2966	Psort location CytoplasmicMembrane, score
M478_2419	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M478_242	COG0443	Heat shock 70 kDa protein
M478_2425	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M478_2426	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M478_2428	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M478_2429	COG0564	pseudouridine synthase activity
M478_243	COG2239	Acts as a magnesium transporter
M478_2439	COG3501	Rhs element vgr protein
M478_244	COG0248	Ppx GppA phosphatase
M478_2446	COG2885	chlorophyll binding
M478_2446	COG3047	cAMP biosynthetic process
M478_245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M478_2450	COG0417	DNA replication proofreading
M478_2451	COG0586	Pfam SNARE associated Golgi protein
M478_2453	COG1178	ABC-type Fe3 transport system permease component
M478_2454	COG4143	(ABC) transporter
M478_2457	COG2814	Major facilitator Superfamily
M478_2460	COG0473	3-isopropylmalate dehydrogenase activity
M478_2462	COG1943	Transposase
M478_2464	COG1047	Peptidyl-prolyl cis-trans
M478_2467	COG0196	riboflavin kinase activity
M478_2469	COG0583	DNA-binding transcription factor activity
M478_247	COG0581	inorganic phosphate transmembrane transporter activity
M478_2473	COG1584	GPR1 FUN34 yaaH family protein
M478_2476	COG0521	Mo-molybdopterin cofactor biosynthetic process
M478_2484	COG0745	RESPONSE REGULATOR receiver
M478_2485	COG3045	CreA protein
M478_2488	COG2207	Transcriptional regulator
M478_2488	COG3708	Transcriptional regulator
M478_2489	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
M478_2491	COG0741	lytic transglycosylase activity
M478_2494	COG2199	diguanylate cyclase activity
M478_2495	COG2885	chlorophyll binding
M478_2496	COG0488	(ABC) transporter
M478_2497	COG0488	(ABC) transporter
M478_25	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M478_2501	COG0560	Phosphoserine phosphatase
M478_2502	COG3726	membrane protein affecting hemolysin expression
M478_2507	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M478_2508	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M478_2509	COG0084	hydrolase, TatD family'
M478_251	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M478_2510	COG4667	esterase of the alpha-beta hydrolase superfamily
M478_2512	COG2823	Periplasmic or secreted lipoprotein
M478_2514	COG0456	acetyltransferase
M478_2515	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
M478_2519	COG3706	GGDEF domain
M478_252	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M478_2522	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M478_2523	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M478_2526	COG0859	PFAM glycosyl transferase family 9
M478_2528	COG2390	Transcriptional regulator
M478_2529	COG2390	Transcriptional regulator
M478_2537	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M478_2537	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_2537	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_2538	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M478_2539	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M478_2540	COG2207	Transcriptional regulator
M478_2541	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M478_2543	COG4269	membrane
M478_255	COG1943	Transposase
M478_2553	COG2963	transposase activity
M478_2555	COG1401	restriction endodeoxyribonuclease activity
M478_2560	COG1295	ribonuclease BN
M478_2561	COG1011	Hydrolase
M478_2563	COG0174	glutamine synthetase
M478_2564	COG3852	Histidine kinase
M478_2566	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M478_2569	COG1943	Transposase
M478_257	COG1393	Belongs to the ArsC family
M478_2570	COG1943	Transposase
M478_2571	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M478_2571	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M478_2572	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M478_2573	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M478_2574	COG3084	Protein conserved in bacteria
M478_2576	COG1763	Mo-molybdopterin cofactor biosynthetic process
M478_2577	COG3328	transposase activity
M478_258	COG4783	chaperone-mediated protein folding
M478_2585	COG0151	Belongs to the GarS family
M478_2588	COG3068	Protein conserved in bacteria
M478_2589	COG1515	deoxyribonuclease V activity
M478_259	COG0628	permease
M478_2594	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M478_2596	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M478_26	COG0772	Belongs to the SEDS family
M478_2600	COG1943	Transposase
M478_2608	COG0250	Participates in transcription elongation, termination and antitermination
M478_2609	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M478_262	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M478_2620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M478_2626	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
M478_2627	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M478_2628	COG1739	Uncharacterized protein family UPF0029
M478_2629	COG1943	Transposase
M478_263	COG2716	regulation of RNA biosynthetic process
M478_2630	COG1739	Uncharacterized protein family UPF0029
M478_2643	COG0805	protein transport
M478_2645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M478_2649	COG1322	Protein conserved in bacteria
M478_265	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M478_2650	COG0586	Pfam SNARE associated Golgi protein
M478_2651	COG1966	Carbon starvation protein
M478_2653	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M478_2654	COG0412	Dienelactone hydrolase
M478_2657	COG0583	DNA-binding transcription factor activity
M478_2658	COG0679	Auxin Efflux Carrier
M478_2659	COG0584	glycerophosphoryl diester phosphodiesterase
M478_266	COG1943	Transposase
M478_2671	COG0410	ABC transporter
M478_2672	COG0411	ABC transporter
M478_2673	COG4177	L-phenylalanine transmembrane transporter activity
M478_2674	COG0559	Belongs to the binding-protein-dependent transport system permease family
M478_2675	COG0683	leucine binding
M478_2677	COG1943	Transposase
M478_2679	COG2177	Part of the ABC transporter FtsEX involved in
M478_268	COG2321	neutral zinc metallopeptidase
M478_2680	COG2884	Cell division ATP-binding protein ftsE
M478_2681	COG0552	protein localization to endoplasmic reticulum
M478_2681	COG0552	protein localization to endoplasmic reticulum
M478_2682	COG0742	ribosomal rna small subunit methyltransferase
M478_2683	COG3776	membrane
M478_2686	COG3714	YhhN family
M478_2689	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M478_2691	COG0247	lactate metabolic process
M478_2693	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M478_2694	COG0584	glycerophosphoryl diester phosphodiesterase
M478_2696	COG0561	phosphatase activity
M478_2697	COG2267	carboxylic ester hydrolase activity
M478_2698	COG1280	lysine exporter protein (LysE YggA)
M478_2699	COG1280	lysine exporter protein (LysE YggA)
M478_27	COG0768	penicillin binding
M478_2700	COG0514	ATP-dependent DNA helicase (RecQ)
M478_2701	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
M478_2702	COG2050	protein possibly involved in aromatic compounds catabolism
M478_2704	COG0598	Magnesium transport protein CorA
M478_2705	COG5564	TIM-barrel signal transduction protein
M478_2706	COG5441	Belongs to the UPF0261 family
M478_2708	COG0210	DNA helicase
M478_2709	COG1011	Hydrolase
M478_2710	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M478_2711	COG3159	Protein conserved in bacteria
M478_2713	COG5567	small periplasmic lipoprotein
M478_2715	COG3072	Adenylate cyclase
M478_2717	COG1587	Uroporphyrinogen-III synthase
M478_2718	COG2959	enzyme of heme biosynthesis
M478_2719	COG3071	HemY protein
M478_272	COG1876	peptidase activity
M478_2726	COG1113	amino acid transport
M478_2730	COG2244	polysaccharide biosynthetic process
M478_2731	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M478_2732	COG0456	acetyltransferase
M478_2733	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M478_2734	COG1088	dTDP-glucose 4,6-dehydratase activity
M478_2735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M478_2736	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M478_2737	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M478_2738	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M478_2739	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M478_274	COG1393	Belongs to the ArsC family
M478_2740	COG3118	belongs to the thioredoxin family
M478_2745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M478_2747	COG3328	transposase activity
M478_2749	COG3121	Chaperone
M478_2752	COG3121	Chaperone
M478_2759	COG0583	DNA-binding transcription factor activity
M478_276	COG1840	ABC-type Fe3 transport system, periplasmic component
M478_2767	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M478_2768	COG3978	acetolactate synthase activity
M478_277	COG1175	transmembrane transport
M478_2771	COG3085	chromosome segregation
M478_2772	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_2774	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_2775	COG1129	ABC transporter
M478_2776	COG1879	ABC-type sugar transport system periplasmic component
M478_278	COG3842	ATPase activity
M478_279	COG3119	arylsulfatase activity
M478_2790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M478_2790	COG0678	peroxiredoxin activity
M478_2791	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M478_2796	COG1629	transport
M478_280	COG0641	radical SAM
M478_2800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M478_2804	COG2801	Transposase and inactivated derivatives
M478_2806	COG0527	aspartate kinase activity
M478_2806	COG0460	homoserine dehydrogenase
M478_2807	COG0626	cystathionine gamma-synthase activity
M478_2809	COG4682	membrane
M478_281	COG1988	membrane-bound metal-dependent
M478_2811	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M478_2813	COG1609	Transcriptional regulator
M478_2814	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M478_2817	COG1575	Belongs to the MenA family. Type 1 subfamily
M478_2828	COG1943	Transposase
M478_283	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M478_2830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M478_2831	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M478_2832	COG1494	fructose-1,6-bisphosphatase
M478_2834	COG3152	Membrane
M478_2837	COG0583	DNA-binding transcription factor activity
M478_2838	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M478_2839	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M478_2840	COG0471	metal ion transport
M478_2842	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M478_2847	COG3678	ATP-independent chaperone mediated protein folding
M478_2848	COG0745	RESPONSE REGULATOR receiver
M478_2849	COG2205	protein histidine kinase activity
M478_285	COG2197	response regulator
M478_2850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M478_2850	COG2169	Transcriptional regulator
M478_2851	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M478_2852	COG1045	serine acetyltransferase
M478_2855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M478_2856	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M478_2858	COG4942	peptidase
M478_2859	COG2861	carbohydrate metabolic process
M478_286	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M478_286	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
M478_2860	COG2861	carbohydrate metabolic process
M478_2862	COG0156	8-amino-7-oxononanoate synthase activity
M478_2864	COG0859	PFAM glycosyl transferase family 9
M478_2865	COG0859	PFAM glycosyl transferase family 9
M478_2866	COG1519	Transferase
M478_287	COG3062	negative regulation of establishment of protein localization
M478_2870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M478_2873	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M478_2878	COG1561	YicC-like family, N-terminal region
M478_2879	COG2860	membrane
M478_2880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M478_2883	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M478_2884	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M478_2885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M478_2886	COG0786	glutamate:sodium symporter activity
M478_2887	COG2233	PERMEase
M478_2888	COG2982	Protein involved in outer membrane biogenesis
M478_2889	COG0456	acetyltransferase
M478_2892	COG0435	Glutathione S-transferase
M478_2893	COG0583	DNA-binding transcription factor activity
M478_2894	COG1741	Belongs to the pirin family
M478_2895	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M478_2899	COG2823	Periplasmic or secreted lipoprotein
M478_29	COG0799	negative regulation of ribosome biogenesis
M478_290	COG3043	anaerobic respiration
M478_2901	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M478_2902	COG0784	Response regulator, receiver
M478_2902	COG2198	Histidine kinase
M478_2902	COG5002	protein histidine kinase activity
M478_2903	COG1242	4 iron, 4 sulfur cluster binding
M478_2904	COG0070	glutamate synthase
M478_2904	COG0069	glutamate synthase activity
M478_2904	COG0067	glutamate synthase
M478_2905	COG0493	'glutamate synthase
M478_2907	COG2969	positive regulation of protein catabolic process
M478_2908	COG0625	glutathione transferase activity
M478_291	COG3005	denitrification pathway
M478_2911	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M478_2912	COG3105	Protein conserved in bacteria
M478_2913	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M478_2914	COG1943	Transposase
M478_2915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M478_2917	COG5007	Belongs to the BolA IbaG family
M478_2918	COG3113	response to antibiotic
M478_2919	COG2854	intermembrane phospholipid transfer
M478_2920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M478_2921	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M478_2922	COG1127	ABC transporter
M478_2923	COG0530	calcium, potassium:sodium antiporter activity
M478_2924	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M478_2924	COG0517	IMP dehydrogenase activity
M478_2925	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M478_2926	COG3117	lipopolysaccharide transmembrane transporter activity
M478_2927	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M478_2928	COG1137	ATPase activity
M478_2929	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M478_2931	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_2933	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_2938	COG1609	Transcriptional regulator
M478_2939	COG1263	PTS System
M478_2939	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M478_2940	COG0366	Alpha amylase catalytic
M478_2941	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M478_2942	COG3783	Cytochrome b(562)
M478_2944	COG0312	modulator of DNA gyrase
M478_2946	COG2732	(Barnase) inhibitor
M478_2949	COG1012	belongs to the aldehyde dehydrogenase family
M478_2953	COG0583	DNA-binding transcription factor activity
M478_2963	COG0312	modulator of DNA gyrase
M478_2964	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M478_2965	COG3164	Protein of unknown function
M478_2966	COG1530	ribonuclease E activity
M478_2968	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M478_2969	COG1792	Involved in formation and maintenance of cell shape
M478_2970	COG1077	Cell shape determining protein MreB Mrl
M478_2971	COG2199	diguanylate cyclase activity
M478_2971	COG2200	EAL domain
M478_2972	COG0604	alcohol dehydrogenase
M478_2973	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M478_2976	COG0511	ligase activity, forming carbon-carbon bonds
M478_2977	COG0439	Biotin carboxylase
M478_2979	COG3924	membrane
M478_2980	COG4145	pantothenate transmembrane transporter activity
M478_2982	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M478_2983	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M478_2987	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M478_2989	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M478_2990	COG3133	Outer membrane lipoprotein
M478_2991	COG1278	Cold shock
M478_2992	COG1278	Cold shock
M478_2993	COG1943	Transposase
M478_2996	COG0625	glutathione transferase activity
M478_2998	COG1069	ribulokinase activity
M478_3	COG1879	ABC-type sugar transport system periplasmic component
M478_300	COG3111	PFAM Bacterial OB fold (BOF) protein
M478_3000	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_3001	COG1129	ABC transporter
M478_3003	COG1560	Kdo2-lipid A biosynthetic process
M478_3005	COG0025	NhaP-type Na H and K H
M478_3006	COG2252	PERMEase
M478_3007	COG3077	Addiction module antitoxin, RelB DinJ family
M478_3009	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M478_3011	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M478_3012	COG0431	NADPH-dependent FMN reductase
M478_3014	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M478_3015	COG1869	D-ribose catabolic process
M478_3016	COG1917	Cupin 2, conserved barrel domain protein
M478_3016	COG2207	Transcriptional regulator
M478_3017	COG0673	inositol 2-dehydrogenase activity
M478_302	COG2837	iron assimilation
M478_3020	COG3209	COG3209 Rhs family protein
M478_3022	COG3501	Rhs element vgr protein
M478_3028	COG3209	COG3209 Rhs family protein
M478_303	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M478_3031	COG3501	Rhs element vgr protein
M478_305	COG4886	Leucine-rich repeat (LRR) protein
M478_3061	COG1175	transmembrane transport
M478_3062	COG3833	ABC-type maltose transport systems, permease component
M478_3065	COG0527	aspartate kinase activity
M478_307	COG2731	YhcH YjgK YiaL family protein
M478_3070	COG1414	Transcriptional regulator
M478_3071	COG1414	Transcriptional regulator
M478_3073	COG2224	Isocitrate lyase
M478_3074	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M478_308	COG1737	Transcriptional regulator
M478_3084	COG2186	Transcriptional regulator
M478_3086	COG0477	Major facilitator Superfamily
M478_3087	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M478_3093	COG1522	sequence-specific DNA binding
M478_3094	COG0716	FMN binding
M478_3097	COG3312	ion transport
M478_31	COG1466	dna polymerase III delta subunit
M478_310	COG4150	thiosulfate binding
M478_3107	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M478_3108	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M478_3109	COG0573	inorganic phosphate transmembrane transporter activity
M478_311	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M478_3110	COG0581	inorganic phosphate transmembrane transporter activity
M478_3112	COG0704	Plays a role in the regulation of phosphate uptake
M478_3114	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_3115	COG0765	amino acid transport
M478_3116	COG0765	amino acid transport
M478_3117	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M478_3118	COG2252	PERMEase
M478_312	COG4208	sulfate ABC transporter
M478_3123	COG0706	membrane insertase activity
M478_3126	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M478_3129	COG0592	DNA-directed DNA polymerase activity
M478_313	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M478_3130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M478_3131	COG0187	DNA topoisomerase II activity
M478_3132	COG0561	phosphatase activity
M478_3133	COG2801	Transposase and inactivated derivatives
M478_3136	COG2423	ornithine cyclodeaminase activity
M478_3137	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M478_3138	COG0823	Involved in the tonB-independent uptake of proteins
M478_3139	COG0823	Involved in the tonB-independent uptake of proteins
M478_3140	COG5645	(Lipo)protein
M478_3144	COG3977	Valine--pyruvate aminotransferase
M478_3146	COG0366	Alpha amylase catalytic
M478_3149	COG2885	chlorophyll binding
M478_3151	COG2818	Glycosylase
M478_3156	COG2213	PTS system mannitol-specific
M478_3156	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_3158	COG3722	fumarate hydratase activity
M478_316	COG0745	RESPONSE REGULATOR receiver
M478_3165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M478_3167	COG3383	formate dehydrogenase (NAD+) activity
M478_3167	COG0243	molybdopterin cofactor binding
M478_3168	COG0243	molybdopterin cofactor binding
M478_3168	COG3383	formate dehydrogenase (NAD+) activity
M478_3169	COG0437	4 iron, 4 sulfur cluster binding
M478_317	COG5002	protein histidine kinase activity
M478_317	COG3850	Histidine kinase
M478_3170	COG2864	formate dehydrogenase
M478_3173	COG3276	selenocysteine insertion sequence binding
M478_3180	COG2801	Transposase and inactivated derivatives
M478_3182	COG3274	enterobacterial common antigen metabolic process
M478_3184	COG3188	usher protein
M478_3185	COG3188	usher protein
M478_3186	COG3121	Chaperone
M478_3188	COG1070	Carbohydrate kinase
M478_319	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M478_3190	COG4213	ABC transporter substrate-binding protein
M478_3192	COG4214	carbohydrate transport
M478_3193	COG1609	Transcriptional regulator
M478_3193	COG2207	Transcriptional regulator
M478_3195	COG0582	viral genome integration into host DNA
M478_3202	COG4604	ABC transporter, ATP-binding protein
M478_3204	COG4605	iron ion homeostasis
M478_3206	COG4607	ABC-type enterochelin transport system periplasmic component
M478_3209	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M478_321	COG0006	proline dipeptidase activity
M478_3212	COG2986	histidine ammonia-lyase
M478_3215	COG2194	sulfuric ester hydrolase activity
M478_3216	COG2197	response regulator
M478_3217	COG3851	Histidine kinase
M478_3220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M478_3223	COG0551	DNA topoisomerase type I activity
M478_3225	COG0758	DNA mediated transformation
M478_3229	COG0569	domain protein
M478_323	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M478_3231	COG3036	rescue of stalled ribosome
M478_3232	COG0789	Transcriptional regulator
M478_3235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M478_3238	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M478_3239	COG0201	protein transport
M478_3241	COG1841	ribosomal large subunit assembly
M478_3249	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M478_3250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M478_3252	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M478_3253	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M478_3255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M478_326	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M478_3260	COG0051	transcription antitermination factor activity, RNA binding
M478_3263	COG1943	Transposase
M478_3266	COG0049	tRNA binding
M478_3267	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M478_327	COG0745	RESPONSE REGULATOR receiver
M478_3271	COG2964	Protein conserved in bacteria
M478_3272	COG0545	Peptidyl-prolyl cis-trans isomerase
M478_3274	COG1047	Peptidyl-prolyl cis-trans
M478_3275	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M478_3278	COG0488	(ABC) transporter
M478_3279	COG0488	(ABC) transporter
M478_328	COG2205	protein histidine kinase activity
M478_3280	COG1216	Glycosyl transferase, family 2
M478_3282	COG2175	clavaminate synthase activity
M478_3283	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M478_3285	COG4521	taurine ABC transporter
M478_3287	COG0429	hydrolase of the alpha beta-hydrolase fold
M478_3289	COG3954	Phosphoribulokinase
M478_3291	COG1765	OsmC-like protein
M478_3293	COG1289	transmembrane transporter activity
M478_3296	COG0433	COG0433 Predicted ATPase
M478_3297	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M478_3298	COG1486	melibiose metabolic process
M478_330	COG1943	Transposase
M478_3302	COG0402	S-adenosylhomocysteine deaminase activity
M478_3303	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M478_3304	COG2146	nitrite reductase [NAD(P)H] activity
M478_3307	COG0180	Tryptophanyl-tRNA synthetase
M478_3308	COG0546	phosphoglycolate phosphatase activity
M478_3309	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M478_331	COG2190	(PTS) system
M478_3314	COG4796	Type ii and iii secretion system protein
M478_3319	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M478_3320	COG0494	nUDIX hydrolase
M478_3323	COG1011	Hydrolase
M478_3324	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M478_3328	COG0745	RESPONSE REGULATOR receiver
M478_3329	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M478_333	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_3330	COG2183	response to ionizing radiation
M478_3331	COG1918	ferrous iron import across plasma membrane
M478_3338	COG1640	4-alpha-glucanotransferase
M478_3339	COG0058	SHG alpha-glucan phosphorylase activity
M478_334	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M478_3340	COG0058	SHG alpha-glucan phosphorylase activity
M478_3344	COG1349	DNA-binding transcription factor activity
M478_3346	COG2801	Transposase and inactivated derivatives
M478_3349	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M478_335	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M478_3350	COG0058	SHG alpha-glucan phosphorylase activity
M478_3352	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M478_3355	COG3275	phosphorelay sensor kinase activity
M478_3361	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M478_3362	COG2095	MarC family integral membrane protein
M478_3366	COG3265	gluconokinase activity
M478_3367	COG2610	gluconate transmembrane transporter activity
M478_3368	COG1609	Transcriptional regulator
M478_3369	COG1741	Belongs to the pirin family
M478_3371	COG0745	RESPONSE REGULATOR receiver
M478_3373	COG0191	fructose-bisphosphate aldolase activity
M478_3375	COG1879	ABC-type sugar transport system periplasmic component
M478_3376	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_3379	COG2081	HI0933 family
M478_338	COG3530	Putative quorum-sensing-regulated virulence factor
M478_3380	COG0306	phosphate transporter
M478_3381	COG1943	Transposase
M478_3383	COG0589	response to stress
M478_3387	COG0339	signal peptide processing
M478_3388	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M478_3389	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M478_3390	COG3835	regulator
M478_3391	COG2610	gluconate transmembrane transporter activity
M478_3392	COG1929	Belongs to the glycerate kinase type-1 family
M478_3397	COG1295	ribonuclease BN
M478_3398	COG2982	Protein involved in outer membrane biogenesis
M478_3399	COG2134	cdp-diacylglycerol pyrophosphatase
M478_34	COG2888	peptidyl-tyrosine sulfation
M478_3400	COG2200	EAL domain
M478_3401	COG1942	4-Oxalocrotonate Tautomerase
M478_3402	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M478_3403	COG0612	Peptidase, M16
M478_3408	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M478_3409	COG2199	diguanylate cyclase activity
M478_3409	COG2200	EAL domain
M478_3410	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M478_3411	COG4608	Belongs to the ABC transporter superfamily
M478_3412	COG0444	Belongs to the ABC transporter superfamily
M478_3413	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M478_3414	COG0601	transmembrane transport
M478_3415	COG0747	negative chemotaxis
M478_3417	COG2831	hemolysin activation secretion protein
M478_3421	COG2271	Major facilitator Superfamily
M478_3429	COG3162	membrane
M478_3431	COG1301	dicarboxylic acid transport
M478_344	COG1943	Transposase
M478_3454	COG2391	methyltransferase activity
M478_3455	COG0425	Belongs to the sulfur carrier protein TusA family
M478_3456	COG0583	DNA-binding transcription factor activity
M478_3457	COG0814	amino acid
M478_3458	COG0626	cystathionine gamma-synthase activity
M478_3460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M478_3461	COG4558	Periplasmic binding protein
M478_3462	COG3720	iron ion transport
M478_3463	COG4771	TonB-dependent receptor
M478_3464	COG0702	epimerase
M478_3465	COG3721	Heme iron utilization protein
M478_3470	COG1358	cellular component organization or biogenesis
M478_3482	COG3121	Chaperone
M478_349	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M478_3490	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M478_3492	COG0735	belongs to the Fur family
M478_3493	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M478_3496	COG0305	Participates in initiation and elongation during chromosome replication
M478_3497	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M478_3498	COG1448	Aminotransferase
M478_3499	COG2315	Protein conserved in bacteria
M478_35	COG1126	abc transporter atp-binding protein
M478_3500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M478_3501	COG0629	single-stranded DNA binding
M478_3503	COG1454	alcohol dehydrogenase
M478_3517	COG1309	transcriptional regulator
M478_3518	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M478_3518	COG0493	'glutamate synthase
M478_3519	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M478_352	COG0667	Aldo Keto reductase
M478_3520	COG3383	formate dehydrogenase (NAD+) activity
M478_3523	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M478_3531	COG2076	Multidrug Resistance protein
M478_3532	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M478_3534	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M478_3535	COG1053	succinate dehydrogenase
M478_3537	COG3264	Mechanosensitive ion channel
M478_3537	COG1511	domain protein
M478_3540	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M478_3544	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M478_3545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M478_3545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M478_3546	COG0802	atpase or kinase
M478_3547	COG0860	N-Acetylmuramoyl-L-alanine amidase
M478_3551	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M478_3552	COG0330	HflC and HflK could
M478_3553	COG0330	HflC and HflK could
M478_3554	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M478_3557	COG0557	exoribonuclease II activity
M478_3558	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M478_3559	COG1960	acyl-CoA dehydrogenase activity
M478_3560	COG3650	response to hydrogen peroxide
M478_3564	COG1073	alpha beta
M478_3566	COG0360	Binds together with S18 to 16S ribosomal RNA
M478_3567	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M478_3569	COG1943	Transposase
M478_357	COG0436	Aminotransferase
M478_3571	COG3061	Opacity-associated protein A
M478_3572	COG0545	Peptidyl-prolyl cis-trans isomerase
M478_3574	COG0737	Belongs to the 5'-nucleotidase family
M478_3576	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M478_3578	COG1253	flavin adenine dinucleotide binding
M478_358	COG3038	cytochrome b561
M478_3580	COG0729	surface antigen
M478_3581	COG2911	Protein conserved in bacteria
M478_3582	COG2105	PFAM AIG2 family protein
M478_3583	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M478_3585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M478_3589	COG3423	Transcriptional regulator
M478_3591	COG0142	geranyltranstransferase activity
M478_3594	COG0697	spore germination
M478_3596	COG0642	Histidine kinase
M478_3597	COG0745	RESPONSE REGULATOR receiver
M478_3598	COG2027	D-alanyl-D-alanine carboxypeptidase
M478_3599	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M478_36	COG0765	amino acid transport
M478_3600	COG1534	Rna-binding protein
M478_3602	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M478_3603	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M478_3605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M478_3609	COG0195	Participates in both transcription termination and antitermination
M478_3615	COG2801	Transposase and inactivated derivatives
M478_3618	COG0513	Belongs to the DEAD box helicase family
M478_3621	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M478_3624	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M478_3629	COG3153	acetyltransferase
M478_3633	COG1653	transport
M478_3635	COG0395	ABC-type sugar transport system, permease component
M478_3636	COG3842	ATPase activity
M478_3639	COG0702	epimerase
M478_364	COG3381	protein complex oligomerization
M478_3640	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M478_3641	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
M478_3642	COG3454	Phosphonate metabolism
M478_3643	COG4778	phosphonate C-P lyase system protein PhnL
M478_3644	COG4107	phosphonate C-P lyase system protein PhnK
M478_3645	COG3627	carbon phosphorus lyase activity
M478_3646	COG3626	phosphonate metabolism
M478_3647	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
M478_3648	COG3624	Phosphonate C-P lyase system protein PhnG
M478_3649	COG2188	Transcriptional regulator
M478_365	COG3302	dmso reductase anchor subunit
M478_3653	COG4608	Belongs to the ABC transporter superfamily
M478_3654	COG0444	Belongs to the ABC transporter superfamily
M478_3655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M478_3656	COG0601	transmembrane transport
M478_3659	COG2731	YhcH YjgK YiaL family protein
M478_366	COG0437	4 iron, 4 sulfur cluster binding
M478_3660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M478_3661	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
M478_3663	COG0525	valine-tRNA ligase activity
M478_3664	COG2927	DNA polymerase III (CHI subunit)
M478_3666	COG0795	lipopolysaccharide-transporting ATPase activity
M478_3667	COG0795	lipopolysaccharide-transporting ATPase activity
M478_3669	COG0582	viral genome integration into host DNA
M478_367	COG0243	molybdopterin cofactor binding
M478_3674	COG1943	Transposase
M478_3677	COG0237	dephospho-CoA kinase activity
M478_3679	COG1459	type II secretion system
M478_3680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M478_3681	COG4969	Belongs to the N-Me-Phe pilin family
M478_3683	COG3023	N-Acetylmuramoyl-L-alanine amidase
M478_3684	COG3725	Membrane protein required for beta-lactamase induction
M478_3685	COG1113	amino acid transport
M478_3686	COG2186	Transcriptional regulator
M478_3687	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M478_3688	COG0508	dehydrogenase complex catalyzes the overall conversion of
M478_3689	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M478_3690	COG1943	Transposase
M478_3691	COG1049	propionate catabolic process, 2-methylcitrate cycle
M478_3693	COG0697	spore germination
M478_3697	COG2132	Multicopper oxidase
M478_3698	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M478_3699	COG0288	reversible hydration of carbon dioxide
M478_37	COG0765	amino acid transport
M478_3700	COG1131	(ABC) transporter
M478_3701	COG0842	Transport permease protein
M478_3703	COG0726	polysaccharide deacetylase
M478_3707	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M478_3708	COG0617	tRNA 3'-terminal CCA addition
M478_3709	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M478_3710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M478_3712	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M478_3713	COG1643	Atp-dependent helicase
M478_3714	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M478_3715	COG1120	ATPase activity
M478_3716	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M478_3717	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M478_3721	COG2860	membrane
M478_3723	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M478_3725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M478_3726	COG3850	Histidine kinase
M478_3726	COG3437	response regulator, receiver
M478_3726	COG2205	protein histidine kinase activity
M478_3726	COG4999	Histidine kinase
M478_3727	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M478_3728	COG3956	TIGRFAM MazG family protein
M478_3732	COG0602	queuosine metabolic process
M478_3733	COG0720	synthase
M478_374	COG2951	lytic endotransglycosylase activity
M478_3745	COG0529	Catalyzes the synthesis of activated sulfate
M478_3748	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M478_3753	COG1388	LysM domain
M478_3753	COG4942	peptidase
M478_3754	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M478_3755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M478_3756	COG0698	ribose 5-phosphate isomerase
M478_3757	COG1063	alcohol dehydrogenase
M478_3758	COG1028	Short-chain dehydrogenase reductase Sdr
M478_3759	COG2376	Dihydroxyacetone kinase
M478_3762	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M478_3765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_3766	COG1858	cytochrome C peroxidase
M478_3768	COG4771	TonB-dependent receptor
M478_3770	COG0024	Methionine aminopeptidase
M478_3772	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M478_3772	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M478_3773	COG1070	Carbohydrate kinase
M478_3774	COG3623	hexulose-6-phosphate isomerase
M478_3775	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_3776	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_3777	COG1129	ABC transporter
M478_3778	COG1943	Transposase
M478_3780	COG1349	DNA-binding transcription factor activity
M478_3781	COG0235	Class ii aldolase
M478_3782	COG0243	molybdopterin cofactor binding
M478_3783	COG0437	4 iron, 4 sulfur cluster binding
M478_3784	COG3302	dmso reductase anchor subunit
M478_3785	COG3381	protein complex oligomerization
M478_3786	COG3038	cytochrome b561
M478_3787	COG3783	Cytochrome b(562)
M478_3791	COG1129	ABC transporter
M478_3792	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_3793	COG3959	Transketolase, thiamine diphosphate binding domain
M478_3794	COG3958	Transketolase
M478_3795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M478_3802	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M478_3803	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M478_3808	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M478_3809	COG1238	metal cluster binding
M478_3810	COG2918	glutathione biosynthetic process
M478_3812	COG1943	Transposase
M478_3813	COG4536	flavin adenine dinucleotide binding
M478_3814	COG4137	Cytochrome C assembly protein
M478_3815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M478_3820	COG1943	Transposase
M478_3821	COG3137	Salt-induced outer membrane protein
M478_3822	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M478_3823	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M478_3824	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M478_3825	COG3279	Response regulator of the LytR AlgR family
M478_3826	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M478_3827	COG1605	Chorismate mutase
M478_3827	COG0287	Prephenate dehydrogenase
M478_3828	COG1605	Chorismate mutase
M478_3828	COG0077	Prephenate dehydratase
M478_3833	COG1605	Chorismate mutase
M478_3833	COG0077	Prephenate dehydratase
M478_3834	COG1943	Transposase
M478_3835	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M478_3836	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M478_3837	COG0564	pseudouridine synthase activity
M478_3839	COG0542	response to heat
M478_3846	COG5544	Lipoprotein
M478_3847	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M478_3848	COG0045	succinate-CoA ligase (ADP-forming) activity
M478_3848	COG1042	CoA-binding domain protein
M478_3848	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M478_3850	COG3118	belongs to the thioredoxin family
M478_3851	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M478_3852	COG2814	Major facilitator Superfamily
M478_3853	COG1566	PFAM secretion protein HlyD family protein
M478_3854	COG1846	Transcriptional regulator
M478_3856	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M478_3857	COG2814	Major facilitator Superfamily
M478_386	COG3121	Chaperone
M478_3866	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M478_387	COG3188	usher protein
M478_3871	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M478_3876	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
M478_3878	COG1960	acyl-CoA dehydrogenase activity
M478_388	COG3328	transposase activity
M478_3880	COG3034	peptidoglycan biosynthetic process
M478_3881	COG0121	glutamine amidotransferase
M478_3882	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M478_3883	COG1805	sodium ion transport
M478_3884	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M478_3888	COG1477	protein flavinylation
M478_389	COG3188	usher protein
M478_3892	COG2195	Cleaves the N-terminal amino acid of tripeptides
M478_39	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M478_3903	COG2226	methyltransferase
M478_3908	COG1940	carbohydrate kinase activity
M478_3909	COG0419	ATPase involved in DNA repair
M478_3910	COG0420	3'-5' exonuclease activity
M478_3911	COG0745	RESPONSE REGULATOR receiver
M478_3912	COG5002	protein histidine kinase activity
M478_3914	COG1114	Component of the transport system for branched-chain amino acids
M478_3915	COG1943	Transposase
M478_3917	COG0366	Alpha amylase catalytic
M478_3921	COG0450	alkyl hydroperoxide reductase
M478_3922	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M478_3923	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M478_3925	COG1862	Preprotein translocase
M478_3926	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M478_3927	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M478_3928	COG1943	Transposase
M478_3932	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M478_3932	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M478_3935	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M478_3936	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M478_3937	COG1943	Transposase
M478_3939	COG0142	geranyltranstransferase activity
M478_3942	COG0693	protein deglycase activity
M478_3943	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M478_3945	COG2814	Major facilitator Superfamily
M478_3947	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M478_3948	COG1845	cytochrome c oxidase, subunit III
M478_3949	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M478_3950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M478_3952	COG2223	nitrite transmembrane transporter activity
M478_3953	COG3056	Lipoprotein
M478_3954	COG0271	Belongs to the BolA IbaG family
M478_3959	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M478_3960	COG0776	regulation of translation
M478_3961	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M478_3962	COG1555	photosystem II stabilization
M478_3963	COG0824	Thioesterase
M478_3965	COG4533	DNA binding
M478_3968	COG1522	sequence-specific DNA binding
M478_3969	COG1132	(ABC) transporter
M478_3970	COG1132	(ABC) transporter
M478_3971	COG0347	Belongs to the P(II) protein family
M478_3972	COG0004	ammonium transporteR
M478_3973	COG1946	Acyl-CoA thioesterase
M478_3974	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M478_3975	COG3695	enzyme binding
M478_3979	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M478_3981	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M478_3982	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M478_3983	COG1309	transcriptional regulator
M478_3984	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M478_3985	COG1196	nuclear chromosome segregation
M478_3985	COG3264	Mechanosensitive ion channel
M478_3987	COG2832	Protein of unknown function (DUF454)
M478_3989	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M478_3995	COG0543	2 iron, 2 sulfur cluster binding
M478_3995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M478_3999	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M478_4	COG1129	ABC transporter
M478_40	COG4535	Mg2 and Co2 transporter CorC
M478_4008	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
M478_4009	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
M478_4010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M478_4014	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M478_4015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M478_4016	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M478_4016	COG4651	solute:proton antiporter activity
M478_4017	COG2223	nitrite transmembrane transporter activity
M478_4018	COG0737	Belongs to the 5'-nucleotidase family
M478_4019	COG0737	Belongs to the 5'-nucleotidase family
M478_402	COG3501	Rhs element vgr protein
M478_4020	COG0737	Belongs to the 5'-nucleotidase family
M478_4023	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M478_4024	COG3735	TraB family
M478_4025	COG2217	Heavy metal translocating P-type atpase
M478_4026	COG0789	Transcriptional regulator
M478_4027	COG1585	Membrane protein implicated in regulation of membrane protease activity
M478_4028	COG0330	HflC and HflK could
M478_4029	COG3118	belongs to the thioredoxin family
M478_4030	COG0300	oxidoreductase activity
M478_4031	COG2755	lipolytic protein G-D-S-L family
M478_4032	COG4181	ATPase activity
M478_4033	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M478_4034	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M478_4035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M478_4037	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M478_4040	COG2501	S4 domain
M478_4048	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M478_4049	COG4589	Belongs to the CDS family
M478_4051	COG2267	carboxylic ester hydrolase activity
M478_4052	COG2453	phosphatase
M478_4052	COG0671	phosphoesterase, PA-phosphatase related
M478_4058	COG0667	Aldo Keto reductase
M478_4059	COG0656	L-ascorbic acid biosynthetic process
M478_4064	COG3328	transposase activity
M478_4065	COG2850	peptidyl-arginine hydroxylation
M478_4075	COG3423	Transcriptional regulator
M478_4076	COG4953	penicillin-binding protein 1C
M478_4078	COG1943	Transposase
M478_4079	COG2373	Large extracellular alpha-helical protein
M478_408	COG2824	Alkylphosphonate utilization operon protein PhnA
M478_4085	COG3962	Belongs to the TPP enzyme family
M478_4094	COG1943	Transposase
M478_410	COG1704	LemA family
M478_4103	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M478_4104	COG1475	DNA binding
M478_4105	COG1475	DNA binding
M478_4125	COG3941	tape measure
M478_4132	COG5301	cellulose 1,4-beta-cellobiosidase activity
M478_4132	COG5301	cellulose 1,4-beta-cellobiosidase activity
M478_4134	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M478_414	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M478_4140	COG3328	transposase activity
M478_4143	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M478_415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M478_4159	COG1475	DNA binding
M478_416	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M478_418	COG1138	Cytochrome C-type biogenesis protein
M478_4182	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M478_4184	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M478_419	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M478_4198	COG1192	Involved in chromosome partitioning
M478_4199	COG1475	DNA binding
M478_42	COG1702	phosphate starvation-inducible protein PhoH
M478_420	COG3088	subunit of a heme lyase
M478_420	COG4235	cytochrome complex assembly
M478_4201	COG3609	addiction module antidote protein, CC2985 family
M478_4203	COG5599	Phosphatase
M478_4205	COG2801	Transposase and inactivated derivatives
M478_4209	COG2801	Transposase and inactivated derivatives
M478_421	COG4235	cytochrome complex assembly
M478_421	COG3088	subunit of a heme lyase
M478_4214	COG2801	Transposase and inactivated derivatives
M478_4232	COG0515	serine threonine protein kinase
M478_4234	COG2801	Transposase and inactivated derivatives
M478_424	COG3691	Protein conserved in bacteria
M478_4240	COG2801	Transposase and inactivated derivatives
M478_4241	COG2963	transposase activity
M478_4242	COG5599	Phosphatase
M478_4243	COG1317	bacterial-type flagellum organization
M478_4245	COG4669	(LipO)protein
M478_4254	COG2207	Transcriptional regulator
M478_4256	COG4792	protein secretion
M478_4257	COG4791	protein targeting
M478_4258	COG4794	Type iii secretion
M478_4259	COG4790	Type iii secretion
M478_4260	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M478_4269	COG4789	Type iii secretion
M478_427	COG2062	phosphohistidine phosphatase, SixA
M478_4273	COG0457	Tetratricopeptide repeat
M478_4277	COG4886	Leucine-rich repeat (LRR) protein
M478_4282	COG3177	Filamentation induced by cAMP protein fic
M478_4288	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
M478_429	COG2890	protein-(glutamine-N5) methyltransferase activity
M478_432	COG0730	response to heat
M478_433	COG3101	peptidyl-lysine hydroxylation
M478_436	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M478_437	COG1794	racemase activity, acting on amino acids and derivatives
M478_44	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M478_440	COG0697	spore germination
M478_443	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M478_445	COG0586	Pfam SNARE associated Golgi protein
M478_447	COG0285	dihydrofolate synthase activity
M478_448	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M478_449	COG1286	toxin biosynthetic process
M478_450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M478_451	COG0163	prenyltransferase activity
M478_452	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_453	COG4215	(ABC) transporter
M478_454	COG4160	amino acid transport
M478_455	COG4598	ABC transporter
M478_456	COG1090	epimerase
M478_458	COG0622	Phosphoesterase
M478_459	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M478_460	COG3037	sugar-specific permease SgaT UlaA
M478_461	COG3328	transposase activity
M478_464	COG1609	Transcriptional regulator
M478_465	COG0280	phosphate acetyltransferase
M478_465	COG0857	belongs to the CobB CobQ family
M478_469	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M478_470	COG0490	domain, Protein
M478_470	COG0471	metal ion transport
M478_472	COG0436	Aminotransferase
M478_473	COG0583	DNA-binding transcription factor activity
M478_475	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M478_477	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M478_479	COG1034	ATP synthesis coupled electron transport
M478_482	COG0839	Belongs to the complex I subunit 6 family
M478_484	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M478_485	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M478_489	COG1028	Short-chain dehydrogenase reductase Sdr
M478_490	COG3265	gluconokinase activity
M478_493	COG1609	Transcriptional regulator
M478_494	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M478_497	COG0129	dihydroxy-acid dehydratase activity
M478_499	COG4575	ribosome binding
M478_5	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_501	COG1169	isochorismate synthase
M478_504	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M478_507	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M478_51	COG0367	asparagine synthase
M478_513	COG1126	abc transporter atp-binding protein
M478_514	COG0765	amino acid transport
M478_515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_52	COG0647	UMP catabolic process
M478_521	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M478_525	COG1063	alcohol dehydrogenase
M478_526	COG1879	ABC-type sugar transport system periplasmic component
M478_527	COG1129	ABC transporter
M478_528	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_529	COG1609	Transcriptional regulator
M478_53	COG1846	Transcriptional regulator
M478_53	COG1940	carbohydrate kinase activity
M478_530	COG0583	DNA-binding transcription factor activity
M478_531	COG0473	3-isopropylmalate dehydrogenase activity
M478_532	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M478_533	COG4638	Rieske (2fe-2S)
M478_534	COG4638	Rieske (2fe-2S)
M478_535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M478_536	COG2831	hemolysin activation secretion protein
M478_537	COG3210	domain, Protein
M478_54	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M478_540	COG3210	domain, Protein
M478_543	COG3210	domain, Protein
M478_545	COG3842	ATPase activity
M478_547	COG1609	Transcriptional regulator
M478_550	COG0395	ABC-type sugar transport system, permease component
M478_551	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
M478_555	COG0668	transmembrane transport
M478_556	COG1518	maintenance of DNA repeat elements
M478_557	COG1203	CRISPR-associated helicase, Cas3
M478_56	COG1263	PTS System
M478_56	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M478_56	COG2190	(PTS) system
M478_562	COG0667	Aldo Keto reductase
M478_564	COG0477	Major facilitator Superfamily
M478_566	COG0583	DNA-binding transcription factor activity
M478_567	COG3916	Acyl-homoserine-lactone synthase
M478_568	COG2771	luxR family
M478_57	COG1943	Transposase
M478_572	COG0628	permease
M478_576	COG3328	transposase activity
M478_577	COG3328	transposase activity
M478_578	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M478_581	COG3328	transposase activity
M478_583	COG1530	ribonuclease E activity
M478_584	COG0564	pseudouridine synthase activity
M478_586	COG1399	metal-binding, possibly nucleic acid-binding protein
M478_587	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M478_591	COG1028	Short-chain dehydrogenase reductase Sdr
M478_593	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M478_594	COG1943	Transposase
M478_595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M478_596	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M478_598	COG0470	DNA polymerase III
M478_599	COG0084	hydrolase, TatD family'
M478_6	COG0673	inositol 2-dehydrogenase activity
M478_600	COG1263	PTS System
M478_600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M478_606	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M478_607	COG0537	adenosine 5'-monophosphoramidase activity
M478_608	COG5633	Lipoprotein
M478_611	COG1472	Belongs to the glycosyl hydrolase 3 family
M478_613	COG1252	NADH dehydrogenase
M478_616	COG3328	transposase activity
M478_617	COG3134	Outer membrane lipoprotein
M478_618	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M478_619	COG4591	ABC-type transport system involved in lipoprotein release permease component
M478_62	COG0735	belongs to the Fur family
M478_621	COG4591	ABC-type transport system involved in lipoprotein release permease component
M478_623	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M478_625	COG2850	peptidyl-arginine hydroxylation
M478_627	COG0745	RESPONSE REGULATOR receiver
M478_629	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M478_633	COG1187	pseudouridine synthase activity
M478_634	COG0538	isocitrate dehydrogenase activity
M478_637	COG0840	transmembrane signaling receptor activity
M478_638	COG0702	epimerase
M478_639	COG1733	regulation of RNA biosynthetic process
M478_644	COG1522	sequence-specific DNA binding
M478_646	COG3321	synthase
M478_646	COG1028	Short-chain dehydrogenase reductase Sdr
M478_646	COG0604	alcohol dehydrogenase
M478_648	COG1278	Cold shock
M478_650	COG0840	transmembrane signaling receptor activity
M478_651	COG0840	transmembrane signaling receptor activity
M478_652	COG1285	pathogenesis
M478_657	COG1360	Flagellar Motor Protein
M478_658	COG0643	Histidine kinase
M478_658	COG2198	Histidine kinase
M478_659	COG0835	chemotaxis
M478_66	COG0596	Alpha beta hydrolase
M478_660	COG2271	Major facilitator Superfamily
M478_661	COG0251	oxidation-reduction process
M478_663	COG2964	Protein conserved in bacteria
M478_668	COG0840	transmembrane signaling receptor activity
M478_669	COG0840	transmembrane signaling receptor activity
M478_670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M478_672	COG0745	RESPONSE REGULATOR receiver
M478_673	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M478_674	COG3023	N-Acetylmuramoyl-L-alanine amidase
M478_675	COG5295	Hep Hag repeat protein
M478_676	COG5295	Hep Hag repeat protein
M478_679	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M478_68	COG2963	transposase activity
M478_69	COG0582	viral genome integration into host DNA
M478_691	COG3121	Chaperone
M478_695	COG3008	intermembrane lipid transfer
M478_696	COG2995	paraquat-inducible protein a
M478_697	COG1956	GAF domain-containing protein
M478_699	COG0793	Belongs to the peptidase S41A family
M478_7	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M478_702	COG3539	Fimbrial protein
M478_703	COG3121	Chaperone
M478_706	COG3121	Chaperone
M478_707	COG2814	Major facilitator Superfamily
M478_708	COG0823	Involved in the tonB-independent uptake of proteins
M478_710	COG3023	N-Acetylmuramoyl-L-alanine amidase
M478_712	COG1988	membrane-bound metal-dependent
M478_713	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M478_714	COG1653	transport
M478_715	COG3842	ATPase activity
M478_716	COG0395	ABC-type sugar transport system, permease component
M478_717	COG1175	transmembrane transport
M478_719	COG1028	Short-chain dehydrogenase reductase Sdr
M478_721	COG1917	Cupin 2, conserved barrel domain protein
M478_722	COG3328	transposase activity
M478_723	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M478_726	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M478_727	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M478_728	COG1121	(ABC) transporter
M478_729	COG0803	Belongs to the bacterial solute-binding protein 9 family
M478_73	COG2113	Glycine betaine
M478_733	COG4249	Peptidase C14 caspase catalytic subunit p20
M478_738	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M478_739	COG0072	phenylalanine-tRNA ligase activity
M478_739	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M478_74	COG4176	ABC-type proline glycine betaine transport system permease component
M478_740	COG0776	regulation of translation
M478_743	COG0386	Belongs to the glutathione peroxidase family
M478_744	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
M478_75	COG4175	Glycine betaine
M478_752	COG0791	NLP P60 protein
M478_758	COG0574	Belongs to the PEP-utilizing enzyme family
M478_758	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M478_759	COG0628	permease
M478_76	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M478_760	COG0247	lactate metabolic process
M478_760	COG0277	FAD linked oxidase domain protein
M478_761	COG2050	protein possibly involved in aromatic compounds catabolism
M478_762	COG0316	Belongs to the HesB IscA family
M478_763	COG0719	Fe-S assembly protein
M478_764	COG0396	ATPase activity
M478_765	COG0719	Fe-S assembly protein
M478_768	COG1376	ErfK ybiS ycfS ynhG family protein
M478_768	COG1388	LysM domain
M478_774	COG4238	major outer membrane lipoprotein
M478_779	COG0307	riboflavin synthase, alpha
M478_780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M478_781	COG2814	Major facilitator Superfamily
M478_782	COG0583	DNA-binding transcription factor activity
M478_785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M478_786	COG0791	NLP P60 protein
M478_788	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M478_789	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M478_790	COG0346	lactoylglutathione lyase activity
M478_791	COG1902	pentaerythritol trinitrate reductase activity
M478_792	COG1309	transcriptional regulator
M478_793	COG2194	sulfuric ester hydrolase activity
M478_795	COG3133	Outer membrane lipoprotein
M478_797	COG3895	Periplasmic Protein
M478_801	COG0625	glutathione transferase activity
M478_804	COG3104	oligopeptide transport
M478_806	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M478_806	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M478_807	COG4172	Belongs to the ABC transporter superfamily
M478_809	COG4171	peptide transport system, permease
M478_810	COG4168	peptide transport system, permease
M478_811	COG4166	transmembrane transport
M478_812	COG1943	Transposase
M478_813	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M478_814	COG1842	Phage shock protein A
M478_816	COG1983	PspC domain protein
M478_818	COG3106	COG3106 Predicted ATPase
M478_824	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M478_825	COG4948	Mandelate Racemase Muconate Lactonizing
M478_826	COG2866	Carboxypeptidase
M478_827	COG4166	transmembrane transport
M478_830	COG2755	lipolytic protein G-D-S-L family
M478_830	COG0657	acetylesterase activity
M478_833	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M478_833	COG0674	pyruvate-flavodoxin oxidoreductase activity
M478_833	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M478_833	COG1013	pyruvate-flavodoxin oxidoreductase activity
M478_835	COG1285	pathogenesis
M478_836	COG3042	response to heat
M478_837	COG3187	Heat shock protein
M478_838	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M478_839	COG2911	Protein conserved in bacteria
M478_84	COG1278	Cold shock
M478_841	COG3784	Protein of unknown function (DUF1318)
M478_842	COG0246	Mannitol dehydrogenase
M478_843	COG2390	Transcriptional regulator
M478_845	COG1643	Atp-dependent helicase
M478_848	COG3591	Belongs to the peptidase S1B family
M478_85	COG0747	negative chemotaxis
M478_850	COG3038	cytochrome b561
M478_856	COG1454	alcohol dehydrogenase
M478_856	COG1012	belongs to the aldehyde dehydrogenase family
M478_857	COG2095	MarC family integral membrane protein
M478_859	COG0601	transmembrane transport
M478_860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M478_861	COG0444	Belongs to the ABC transporter superfamily
M478_862	COG4608	Belongs to the ABC transporter superfamily
M478_869	COG2350	Protein conserved in bacteria
M478_87	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M478_871	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M478_872	COG3328	transposase activity
M478_873	COG1607	acyl-coa hydrolase
M478_878	COG3047	cAMP biosynthetic process
M478_88	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M478_882	COG0135	phosphoribosylanthranilate isomerase activity
M478_882	COG0134	indole-3-glycerol-phosphate synthase activity
M478_884	COG0512	Glutamine amidotransferase of anthranilate synthase
M478_887	COG0009	L-threonylcarbamoyladenylate synthase
M478_888	COG1187	pseudouridine synthase activity
M478_89	COG1124	(ABC) transporter
M478_890	COG1028	Short-chain dehydrogenase reductase Sdr
M478_891	COG0616	signal peptide processing
M478_894	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M478_895	COG0583	DNA-binding transcription factor activity
M478_897	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M478_898	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M478_899	COG0671	phosphoesterase, PA-phosphatase related
M478_9	COG3718	enzyme involved in inositol metabolism
M478_900	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M478_901	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M478_904	COG0023	Translation Initiation Factor
M478_908	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M478_909	COG2879	small protein
M478_910	COG1966	Carbon starvation protein
M478_912	COG2271	Major facilitator Superfamily
M478_913	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M478_914	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M478_916	COG4659	FMN binding
M478_917	COG4658	electron transport chain
M478_918	COG2207	Transcriptional regulator
M478_918	COG3708	Transcriptional regulator
M478_925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M478_926	COG2274	protein secretion by the type I secretion system
M478_930	COG1879	ABC-type sugar transport system periplasmic component
M478_932	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_934	COG0673	inositol 2-dehydrogenase activity
M478_935	COG0385	Bile acid
M478_937	COG5339	Protein conserved in bacteria
M478_939	COG0114	fumarate hydratase activity
M478_941	COG2814	Major facilitator Superfamily
M478_942	COG0583	DNA-binding transcription factor activity
M478_943	COG1940	carbohydrate kinase activity
M478_945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M478_946	COG0038	chloride channel
M478_947	COG1609	Transcriptional regulator
M478_949	COG1879	ABC-type sugar transport system periplasmic component
M478_950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M478_951	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M478_953	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M478_958	COG0028	Belongs to the TPP enzyme family
M478_959	COG0440	acetolactate synthase activity
M478_96	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M478_960	COG1011	Hydrolase
M478_963	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M478_964	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M478_965	COG0589	response to stress
M478_966	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M478_967	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M478_969	COG0531	amino acid
M478_971	COG0745	RESPONSE REGULATOR receiver
M478_972	COG2205	protein histidine kinase activity
M478_973	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M478_974	COG1943	Transposase
M478_98	COG4413	Urea transporter
M478_980	COG1435	thymidine kinase activity
M478_983	COG0745	RESPONSE REGULATOR receiver
M478_985	COG3328	transposase activity
M478_986	COG0788	formyltetrahydrofolate deformylase activity
M478_99	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M478_990	COG0583	DNA-binding transcription factor activity
M478_991	COG0708	Exodeoxyribonuclease III
M478_992	COG0494	nUDIX hydrolase
M478_994	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M478_995	COG0709	Synthesizes selenophosphate from selenide and ATP
M478_996	COG0778	Nitroreductase
M478_997	COG0616	signal peptide processing
M478_998	COG0252	asparaginase activity
M478_999	COG1335	isochorismatase