locus-tag	class	description
M483_10	COG3422	double-strand break repair
M483_100	COG1943	Transposase
M483_1005	COG0250	Participates in transcription elongation, termination and antitermination
M483_1006	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M483_1017	COG2986	histidine ammonia-lyase
M483_102	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M483_1020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M483_1023	COG4607	ABC-type enterochelin transport system periplasmic component
M483_1025	COG4605	iron ion homeostasis
M483_1027	COG4604	ABC transporter, ATP-binding protein
M483_103	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
M483_1034	COG0582	viral genome integration into host DNA
M483_1036	COG2207	Transcriptional regulator
M483_1036	COG1609	Transcriptional regulator
M483_1037	COG4214	carbohydrate transport
M483_1039	COG4213	ABC transporter substrate-binding protein
M483_104	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M483_1041	COG1070	Carbohydrate kinase
M483_1043	COG3121	Chaperone
M483_1044	COG3188	usher protein
M483_1045	COG3188	usher protein
M483_1047	COG3274	enterobacterial common antigen metabolic process
M483_1049	COG2801	Transposase and inactivated derivatives
M483_105	COG3173	Aminoglycoside phosphotransferase
M483_1051	COG0460	homoserine dehydrogenase
M483_1051	COG0527	aspartate kinase activity
M483_1052	COG0626	cystathionine gamma-synthase activity
M483_1054	COG4682	membrane
M483_1056	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M483_1058	COG1609	Transcriptional regulator
M483_1059	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M483_1062	COG1575	Belongs to the MenA family. Type 1 subfamily
M483_1068	COG1943	Transposase
M483_107	COG2835	tetraacyldisaccharide 4'-kinase activity
M483_1070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M483_1071	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M483_1072	COG1494	fructose-1,6-bisphosphatase
M483_1074	COG3152	Membrane
M483_1077	COG0583	DNA-binding transcription factor activity
M483_1078	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M483_1079	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M483_108	COG1278	Cold shock
M483_1080	COG0471	metal ion transport
M483_1081	COG0471	metal ion transport
M483_1083	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M483_1088	COG3678	ATP-independent chaperone mediated protein folding
M483_1089	COG0745	RESPONSE REGULATOR receiver
M483_109	COG5383	Protein conserved in bacteria
M483_1090	COG2205	protein histidine kinase activity
M483_1091	COG2169	Transcriptional regulator
M483_1091	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M483_1092	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M483_1093	COG1045	serine acetyltransferase
M483_1096	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M483_1097	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M483_1099	COG4942	peptidase
M483_1100	COG2861	carbohydrate metabolic process
M483_1101	COG2861	carbohydrate metabolic process
M483_1103	COG0156	8-amino-7-oxononanoate synthase activity
M483_1105	COG0859	PFAM glycosyl transferase family 9
M483_1106	COG0859	PFAM glycosyl transferase family 9
M483_1107	COG1519	Transferase
M483_1111	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M483_1114	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M483_1119	COG1561	YicC-like family, N-terminal region
M483_112	COG2333	competence protein COMEC
M483_112	COG0658	competence protein
M483_1120	COG2860	membrane
M483_1121	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M483_1124	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M483_1125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M483_1126	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M483_1127	COG0786	glutamate:sodium symporter activity
M483_1128	COG2233	PERMEase
M483_1129	COG2982	Protein involved in outer membrane biogenesis
M483_1130	COG0456	acetyltransferase
M483_1134	COG1295	ribonuclease BN
M483_1135	COG1011	Hydrolase
M483_1137	COG0174	glutamine synthetase
M483_1138	COG3852	Histidine kinase
M483_1140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M483_1143	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M483_1143	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M483_1144	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M483_1145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M483_1146	COG3084	Protein conserved in bacteria
M483_1148	COG1763	Mo-molybdopterin cofactor biosynthetic process
M483_1149	COG3328	transposase activity
M483_115	COG0539	negative regulation of cytoplasmic translation
M483_1154	COG2186	Transcriptional regulator
M483_1156	COG0477	Major facilitator Superfamily
M483_1157	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M483_1158	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M483_1164	COG1522	sequence-specific DNA binding
M483_1165	COG0716	FMN binding
M483_1168	COG3312	ion transport
M483_1178	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M483_1179	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M483_1180	COG0573	inorganic phosphate transmembrane transporter activity
M483_1181	COG0581	inorganic phosphate transmembrane transporter activity
M483_1183	COG0704	Plays a role in the regulation of phosphate uptake
M483_1185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M483_1186	COG0765	amino acid transport
M483_1187	COG0765	amino acid transport
M483_1188	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M483_1189	COG2252	PERMEase
M483_1194	COG0706	membrane insertase activity
M483_1197	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M483_120	COG5295	Hep Hag repeat protein
M483_120	COG5295	Hep Hag repeat protein
M483_1200	COG0592	DNA-directed DNA polymerase activity
M483_1201	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M483_1202	COG0187	DNA topoisomerase II activity
M483_1203	COG0561	phosphatase activity
M483_1204	COG2801	Transposase and inactivated derivatives
M483_1206	COG2423	ornithine cyclodeaminase activity
M483_1207	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M483_1208	COG0823	Involved in the tonB-independent uptake of proteins
M483_1209	COG0823	Involved in the tonB-independent uptake of proteins
M483_121	COG0252	asparaginase activity
M483_1210	COG5645	(Lipo)protein
M483_1214	COG3977	Valine--pyruvate aminotransferase
M483_1216	COG0366	Alpha amylase catalytic
M483_1219	COG2885	chlorophyll binding
M483_122	COG1944	ATP diphosphatase activity
M483_1221	COG2818	Glycosylase
M483_1226	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M483_1226	COG2213	PTS system mannitol-specific
M483_1228	COG3722	fumarate hydratase activity
M483_123	COG2116	formate transmembrane transporter activity
M483_1235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M483_1237	COG0243	molybdopterin cofactor binding
M483_1237	COG3383	formate dehydrogenase (NAD+) activity
M483_1238	COG0243	molybdopterin cofactor binding
M483_1238	COG3383	formate dehydrogenase (NAD+) activity
M483_1239	COG0437	4 iron, 4 sulfur cluster binding
M483_124	COG1882	Formate acetyltransferase
M483_1240	COG2864	formate dehydrogenase
M483_1243	COG3276	selenocysteine insertion sequence binding
M483_1245	COG3328	transposase activity
M483_1250	COG2801	Transposase and inactivated derivatives
M483_1252	COG1349	DNA-binding transcription factor activity
M483_1256	COG0058	SHG alpha-glucan phosphorylase activity
M483_1257	COG1640	4-alpha-glucanotransferase
M483_126	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M483_1264	COG1918	ferrous iron import across plasma membrane
M483_1265	COG2183	response to ionizing radiation
M483_1266	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M483_1267	COG0745	RESPONSE REGULATOR receiver
M483_127	COG2814	Major facilitator Superfamily
M483_1271	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M483_1272	COG1011	Hydrolase
M483_1275	COG0494	nUDIX hydrolase
M483_1276	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M483_1281	COG4796	Type ii and iii secretion system protein
M483_1286	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M483_1287	COG0546	phosphoglycolate phosphatase activity
M483_1288	COG0180	Tryptophanyl-tRNA synthetase
M483_129	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M483_1291	COG2146	nitrite reductase [NAD(P)H] activity
M483_1292	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M483_1293	COG0402	S-adenosylhomocysteine deaminase activity
M483_1297	COG1486	melibiose metabolic process
M483_1298	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M483_1299	COG0433	COG0433 Predicted ATPase
M483_1302	COG1289	transmembrane transporter activity
M483_1304	COG1765	OsmC-like protein
M483_1306	COG3954	Phosphoribulokinase
M483_1308	COG0429	hydrolase of the alpha beta-hydrolase fold
M483_1310	COG4521	taurine ABC transporter
M483_1312	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M483_1313	COG2175	clavaminate synthase activity
M483_1316	COG1216	Glycosyl transferase, family 2
M483_1317	COG0488	(ABC) transporter
M483_132	COG3107	peptidoglycan biosynthetic process
M483_132	COG1674	ftsk spoiiie
M483_1320	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M483_1321	COG1047	Peptidyl-prolyl cis-trans
M483_1323	COG0545	Peptidyl-prolyl cis-trans isomerase
M483_1324	COG2964	Protein conserved in bacteria
M483_1329	COG0049	tRNA binding
M483_1332	COG1943	Transposase
M483_1336	COG0051	transcription antitermination factor activity, RNA binding
M483_134	COG0492	ferredoxin-NADP+ reductase activity
M483_1341	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M483_1343	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M483_1344	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M483_1346	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M483_1347	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M483_1355	COG1841	ribosomal large subunit assembly
M483_1357	COG0201	protein transport
M483_1358	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M483_136	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M483_1361	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M483_1364	COG0789	Transcriptional regulator
M483_1365	COG3036	rescue of stalled ribosome
M483_1367	COG0569	domain protein
M483_1371	COG0758	DNA mediated transformation
M483_1373	COG0551	DNA topoisomerase type I activity
M483_1376	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M483_138	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M483_1383	COG2801	Transposase and inactivated derivatives
M483_1389	COG3162	membrane
M483_139	COG1943	Transposase
M483_1391	COG1301	dicarboxylic acid transport
M483_140	COG0542	response to heat
M483_1413	COG2391	methyltransferase activity
M483_1414	COG0425	Belongs to the sulfur carrier protein TusA family
M483_1415	COG0583	DNA-binding transcription factor activity
M483_1416	COG0814	amino acid
M483_1417	COG0626	cystathionine gamma-synthase activity
M483_1419	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M483_142	COG1278	Cold shock
M483_1420	COG4558	Periplasmic binding protein
M483_1421	COG3720	iron ion transport
M483_1422	COG4771	TonB-dependent receptor
M483_1424	COG0702	epimerase
M483_1425	COG3721	Heme iron utilization protein
M483_1430	COG1358	cellular component organization or biogenesis
M483_144	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M483_1442	COG3121	Chaperone
M483_145	COG2990	Protein conserved in bacteria
M483_1451	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M483_1453	COG0735	belongs to the Fur family
M483_1454	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M483_1457	COG0305	Participates in initiation and elongation during chromosome replication
M483_1458	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M483_1459	COG1448	Aminotransferase
M483_146	COG3593	DNA synthesis involved in DNA repair
M483_1460	COG2315	Protein conserved in bacteria
M483_1461	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M483_1462	COG0629	single-stranded DNA binding
M483_1464	COG1454	alcohol dehydrogenase
M483_147	COG2431	L-lysine efflux transmembrane transporter activity
M483_1478	COG1309	transcriptional regulator
M483_1479	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M483_1479	COG0493	'glutamate synthase
M483_1480	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M483_1481	COG3383	formate dehydrogenase (NAD+) activity
M483_1484	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M483_149	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M483_1492	COG2076	Multidrug Resistance protein
M483_1493	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M483_1495	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M483_1496	COG1053	succinate dehydrogenase
M483_1498	COG1511	domain protein
M483_1498	COG3264	Mechanosensitive ion channel
M483_15	COG0351	phosphomethylpyrimidine kinase
M483_150	COG0028	Belongs to the TPP enzyme family
M483_1501	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M483_1504	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M483_1505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M483_1505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M483_1506	COG0802	atpase or kinase
M483_1507	COG0860	N-Acetylmuramoyl-L-alanine amidase
M483_151	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M483_1511	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M483_1512	COG0330	HflC and HflK could
M483_1513	COG0330	HflC and HflK could
M483_1514	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M483_1517	COG0557	exoribonuclease II activity
M483_1518	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M483_1519	COG1960	acyl-CoA dehydrogenase activity
M483_152	COG0702	epimerase
M483_1520	COG3650	response to hydrogen peroxide
M483_1523	COG2194	sulfuric ester hydrolase activity
M483_1524	COG2197	response regulator
M483_1525	COG3851	Histidine kinase
M483_1526	COG2271	Major facilitator Superfamily
M483_153	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M483_1530	COG2831	hemolysin activation secretion protein
M483_1532	COG0747	negative chemotaxis
M483_1533	COG0601	transmembrane transport
M483_1534	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M483_1535	COG0444	Belongs to the ABC transporter superfamily
M483_1536	COG4608	Belongs to the ABC transporter superfamily
M483_1537	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M483_1538	COG2200	EAL domain
M483_1538	COG2199	diguanylate cyclase activity
M483_1539	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M483_1543	COG0612	Peptidase, M16
M483_1544	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M483_1545	COG1942	4-Oxalocrotonate Tautomerase
M483_1546	COG2200	EAL domain
M483_1547	COG2982	Protein involved in outer membrane biogenesis
M483_1548	COG2134	cdp-diacylglycerol pyrophosphatase
M483_1549	COG1295	ribonuclease BN
M483_155	COG1605	Chorismate mutase
M483_1554	COG1929	Belongs to the glycerate kinase type-1 family
M483_1555	COG2610	gluconate transmembrane transporter activity
M483_1556	COG3835	regulator
M483_1557	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M483_1558	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M483_1559	COG0339	signal peptide processing
M483_156	COG1126	abc transporter atp-binding protein
M483_1563	COG0589	response to stress
M483_1565	COG1943	Transposase
M483_1566	COG0306	phosphate transporter
M483_1567	COG2081	HI0933 family
M483_157	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M483_1570	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_1571	COG1879	ABC-type sugar transport system periplasmic component
M483_1573	COG0191	fructose-bisphosphate aldolase activity
M483_1575	COG0745	RESPONSE REGULATOR receiver
M483_1577	COG1741	Belongs to the pirin family
M483_1578	COG1609	Transcriptional regulator
M483_1579	COG1609	Transcriptional regulator
M483_158	COG4215	(ABC) transporter
M483_1580	COG2610	gluconate transmembrane transporter activity
M483_1581	COG3265	gluconokinase activity
M483_1585	COG2095	MarC family integral membrane protein
M483_1586	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M483_159	COG4160	amino acid transport
M483_1593	COG4932	domain protein
M483_1593	COG1388	LysM domain
M483_1593	COG2373	Large extracellular alpha-helical protein
M483_1594	COG3275	phosphorelay sensor kinase activity
M483_1597	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M483_1599	COG0058	SHG alpha-glucan phosphorylase activity
M483_1600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M483_1603	COG2801	Transposase and inactivated derivatives
M483_1607	COG0513	Belongs to the DEAD box helicase family
M483_1610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M483_1613	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M483_1618	COG3153	acetyltransferase
M483_1622	COG1653	transport
M483_1624	COG0395	ABC-type sugar transport system, permease component
M483_1625	COG3842	ATPase activity
M483_1628	COG0702	epimerase
M483_1629	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M483_163	COG1120	ATPase activity
M483_1630	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
M483_1631	COG3454	Phosphonate metabolism
M483_1632	COG4778	phosphonate C-P lyase system protein PhnL
M483_1633	COG4107	phosphonate C-P lyase system protein PhnK
M483_1634	COG3627	carbon phosphorus lyase activity
M483_1635	COG3626	phosphonate metabolism
M483_1636	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
M483_1637	COG3624	Phosphonate C-P lyase system protein PhnG
M483_1638	COG2188	Transcriptional regulator
M483_164	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M483_1642	COG4608	Belongs to the ABC transporter superfamily
M483_1643	COG0444	Belongs to the ABC transporter superfamily
M483_1644	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M483_1645	COG0601	transmembrane transport
M483_1648	COG2731	YhcH YjgK YiaL family protein
M483_1649	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M483_1650	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
M483_1652	COG0525	valine-tRNA ligase activity
M483_1653	COG2927	DNA polymerase III (CHI subunit)
M483_1655	COG0795	lipopolysaccharide-transporting ATPase activity
M483_1656	COG0795	lipopolysaccharide-transporting ATPase activity
M483_1658	COG0582	viral genome integration into host DNA
M483_1664	COG1401	restriction endodeoxyribonuclease activity
M483_1666	COG2963	transposase activity
M483_1676	COG4269	membrane
M483_1678	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M483_1679	COG2207	Transcriptional regulator
M483_1680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M483_1681	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M483_1682	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M483_1682	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M483_1682	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M483_1690	COG2390	Transcriptional regulator
M483_1692	COG0859	PFAM glycosyl transferase family 9
M483_1695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M483_1696	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M483_1699	COG3706	GGDEF domain
M483_1703	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
M483_1704	COG0456	acetyltransferase
M483_1706	COG2823	Periplasmic or secreted lipoprotein
M483_1708	COG4667	esterase of the alpha-beta hydrolase superfamily
M483_1709	COG0084	hydrolase, TatD family'
M483_171	COG1177	transmembrane transport
M483_1710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M483_1711	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M483_1715	COG3726	membrane protein affecting hemolysin expression
M483_1716	COG0560	Phosphoserine phosphatase
M483_172	COG1176	ABC-type spermidine putrescine transport system, permease component I
M483_1721	COG0488	(ABC) transporter
M483_1722	COG2885	chlorophyll binding
M483_1723	COG2199	diguanylate cyclase activity
M483_1726	COG0741	lytic transglycosylase activity
M483_1728	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
M483_1729	COG3708	Transcriptional regulator
M483_1729	COG2207	Transcriptional regulator
M483_173	COG3842	ATPase activity
M483_1732	COG3045	CreA protein
M483_1733	COG0745	RESPONSE REGULATOR receiver
M483_174	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M483_1741	COG0521	Mo-molybdopterin cofactor biosynthetic process
M483_1744	COG1584	GPR1 FUN34 yaaH family protein
M483_1748	COG0583	DNA-binding transcription factor activity
M483_1750	COG0196	riboflavin kinase activity
M483_1753	COG1047	Peptidyl-prolyl cis-trans
M483_1756	COG0505	Belongs to the CarA family
M483_1757	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M483_1758	COG1280	lysine exporter protein (LysE YggA)
M483_1759	COG2966	Psort location CytoplasmicMembrane, score
M483_1761	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M483_1766	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M483_1767	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M483_1769	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M483_177	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M483_1770	COG0564	pseudouridine synthase activity
M483_178	COG0569	domain protein
M483_178	COG2985	domain, Protein
M483_1780	COG3501	Rhs element vgr protein
M483_1787	COG3047	cAMP biosynthetic process
M483_1787	COG2885	chlorophyll binding
M483_1791	COG0417	DNA replication proofreading
M483_1792	COG0586	Pfam SNARE associated Golgi protein
M483_1794	COG1178	ABC-type Fe3 transport system permease component
M483_1795	COG4143	(ABC) transporter
M483_1798	COG2814	Major facilitator Superfamily
M483_18	COG3328	transposase activity
M483_180	COG0671	phosphoesterase, PA-phosphatase related
M483_1801	COG0473	3-isopropylmalate dehydrogenase activity
M483_1805	COG1022	Amp-dependent synthetase and ligase
M483_1806	COG3328	transposase activity
M483_1807	COG0028	Belongs to the TPP enzyme family
M483_1809	COG1943	Transposase
M483_181	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M483_1810	COG1609	Transcriptional regulator
M483_1811	COG1943	Transposase
M483_1815	COG3116	cell division
M483_1816	COG0768	penicillin binding
M483_1817	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M483_1818	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M483_182	COG1349	DNA-binding transcription factor activity
M483_1821	COG0772	Belongs to the SEDS family
M483_1825	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M483_1826	COG0849	cell division
M483_1827	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M483_183	COG0814	amino acid
M483_1832	COG0494	nUDIX hydrolase
M483_1835	COG1943	Transposase
M483_1838	COG0237	dephospho-CoA kinase activity
M483_184	COG1686	Belongs to the peptidase S11 family
M483_1840	COG1459	type II secretion system
M483_1841	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M483_1842	COG4969	Belongs to the N-Me-Phe pilin family
M483_1844	COG3023	N-Acetylmuramoyl-L-alanine amidase
M483_1845	COG3725	Membrane protein required for beta-lactamase induction
M483_1846	COG1113	amino acid transport
M483_1847	COG2186	Transcriptional regulator
M483_1848	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M483_1849	COG0508	dehydrogenase complex catalyzes the overall conversion of
M483_185	COG2011	ABC-type metal ion transport system permease component
M483_1850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M483_1852	COG1049	propionate catabolic process, 2-methylcitrate cycle
M483_1854	COG0697	spore germination
M483_1858	COG2132	Multicopper oxidase
M483_1859	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M483_1860	COG0288	reversible hydration of carbon dioxide
M483_1861	COG1131	(ABC) transporter
M483_1862	COG0842	Transport permease protein
M483_1864	COG0726	polysaccharide deacetylase
M483_1868	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M483_1869	COG0617	tRNA 3'-terminal CCA addition
M483_1870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M483_1871	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M483_1873	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M483_1874	COG1643	Atp-dependent helicase
M483_1875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M483_1876	COG1120	ATPase activity
M483_1877	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M483_1878	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M483_1882	COG2860	membrane
M483_1884	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M483_1886	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M483_1887	COG3437	response regulator, receiver
M483_1887	COG4999	Histidine kinase
M483_1887	COG2205	protein histidine kinase activity
M483_1887	COG3850	Histidine kinase
M483_1888	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M483_1889	COG3956	TIGRFAM MazG family protein
M483_1893	COG0602	queuosine metabolic process
M483_1894	COG0720	synthase
M483_190	COG0625	glutathione transferase activity
M483_1905	COG0529	Catalyzes the synthesis of activated sulfate
M483_1908	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M483_191	COG4771	TonB-dependent receptor
M483_1913	COG1388	LysM domain
M483_1913	COG4942	peptidase
M483_1914	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M483_1915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M483_1916	COG0698	ribose 5-phosphate isomerase
M483_1917	COG1063	alcohol dehydrogenase
M483_1918	COG1028	Short-chain dehydrogenase reductase Sdr
M483_1919	COG2376	Dihydroxyacetone kinase
M483_1922	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M483_1926	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M483_1927	COG1858	cytochrome C peroxidase
M483_1929	COG4771	TonB-dependent receptor
M483_193	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M483_1931	COG0024	Methionine aminopeptidase
M483_1933	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M483_1933	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M483_1934	COG1070	Carbohydrate kinase
M483_1935	COG3623	hexulose-6-phosphate isomerase
M483_1936	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_1937	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_1938	COG1129	ABC transporter
M483_1940	COG1349	DNA-binding transcription factor activity
M483_1941	COG0235	Class ii aldolase
M483_1942	COG0243	molybdopterin cofactor binding
M483_1943	COG0437	4 iron, 4 sulfur cluster binding
M483_1944	COG3302	dmso reductase anchor subunit
M483_1945	COG3381	protein complex oligomerization
M483_1946	COG3038	cytochrome b561
M483_1947	COG3783	Cytochrome b(562)
M483_195	COG1943	Transposase
M483_1951	COG1129	ABC transporter
M483_1952	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_1953	COG3959	Transketolase, thiamine diphosphate binding domain
M483_1954	COG3958	Transketolase
M483_1955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M483_196	COG0833	amino acid
M483_1962	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M483_1963	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M483_1967	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M483_1968	COG1238	metal cluster binding
M483_1969	COG2918	glutathione biosynthetic process
M483_1971	COG1943	Transposase
M483_1972	COG4536	flavin adenine dinucleotide binding
M483_1973	COG4137	Cytochrome C assembly protein
M483_1974	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M483_1979	COG3137	Salt-induced outer membrane protein
M483_198	COG0583	DNA-binding transcription factor activity
M483_1980	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M483_1981	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M483_1982	COG3279	Response regulator of the LytR AlgR family
M483_1983	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M483_1986	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M483_1987	COG0287	Prephenate dehydrogenase
M483_1987	COG1605	Chorismate mutase
M483_1988	COG1605	Chorismate mutase
M483_1988	COG0077	Prephenate dehydratase
M483_1989	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M483_199	COG2855	membrane
M483_1990	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M483_1991	COG0564	pseudouridine synthase activity
M483_1993	COG0542	response to heat
M483_2	COG3842	ATPase activity
M483_2003	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M483_2004	COG2224	Isocitrate lyase
M483_2006	COG1414	Transcriptional regulator
M483_201	COG3188	usher protein
M483_2011	COG0527	aspartate kinase activity
M483_2014	COG3833	ABC-type maltose transport systems, permease component
M483_2015	COG1175	transmembrane transport
M483_202	COG3121	Chaperone
M483_2026	COG2801	Transposase and inactivated derivatives
M483_2042	COG3501	Rhs element vgr protein
M483_2043	COG3501	Rhs element vgr protein
M483_2046	COG3209	COG3209 Rhs family protein
M483_205	COG3710	Transcriptional regulator
M483_2052	COG3501	Rhs element vgr protein
M483_2054	COG3209	COG3209 Rhs family protein
M483_2057	COG0673	inositol 2-dehydrogenase activity
M483_2058	COG2207	Transcriptional regulator
M483_2058	COG1917	Cupin 2, conserved barrel domain protein
M483_2059	COG1869	D-ribose catabolic process
M483_206	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M483_206	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M483_206	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M483_2060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M483_2062	COG0431	NADPH-dependent FMN reductase
M483_2063	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M483_2065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M483_2067	COG3077	Addiction module antitoxin, RelB DinJ family
M483_2068	COG2252	PERMEase
M483_2069	COG0025	NhaP-type Na H and K H
M483_207	COG1105	Belongs to the carbohydrate kinase PfkB family
M483_2071	COG1560	Kdo2-lipid A biosynthetic process
M483_2073	COG1129	ABC transporter
M483_2074	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_2076	COG1069	ribulokinase activity
M483_2078	COG0625	glutathione transferase activity
M483_2081	COG1943	Transposase
M483_2082	COG1278	Cold shock
M483_2083	COG1278	Cold shock
M483_2084	COG3133	Outer membrane lipoprotein
M483_2085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M483_2087	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M483_209	COG0494	nUDIX hydrolase
M483_2091	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M483_2092	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M483_2094	COG4145	pantothenate transmembrane transporter activity
M483_2095	COG3924	membrane
M483_2097	COG0439	Biotin carboxylase
M483_2098	COG0511	ligase activity, forming carbon-carbon bonds
M483_210	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_2101	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M483_2102	COG0604	alcohol dehydrogenase
M483_2103	COG2199	diguanylate cyclase activity
M483_2103	COG2200	EAL domain
M483_2104	COG1077	Cell shape determining protein MreB Mrl
M483_2105	COG1792	Involved in formation and maintenance of cell shape
M483_2106	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M483_2108	COG1530	ribonuclease E activity
M483_2109	COG3164	Protein of unknown function
M483_211	COG1129	ABC transporter
M483_2110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M483_2111	COG0312	modulator of DNA gyrase
M483_2121	COG0583	DNA-binding transcription factor activity
M483_2125	COG1012	belongs to the aldehyde dehydrogenase family
M483_2128	COG2732	(Barnase) inhibitor
M483_213	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M483_2130	COG0312	modulator of DNA gyrase
M483_2132	COG3783	Cytochrome b(562)
M483_2133	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M483_2134	COG0366	Alpha amylase catalytic
M483_2135	COG1263	PTS System
M483_2135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M483_2141	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M483_2143	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M483_2145	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M483_2146	COG1137	ATPase activity
M483_2147	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M483_2148	COG3117	lipopolysaccharide transmembrane transporter activity
M483_2149	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M483_2150	COG0517	IMP dehydrogenase activity
M483_2150	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M483_2151	COG0530	calcium, potassium:sodium antiporter activity
M483_2152	COG1127	ABC transporter
M483_2153	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M483_2154	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M483_2155	COG2854	intermembrane phospholipid transfer
M483_2156	COG3113	response to antibiotic
M483_2157	COG5007	Belongs to the BolA IbaG family
M483_2159	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M483_2160	COG1943	Transposase
M483_2161	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M483_2162	COG3105	Protein conserved in bacteria
M483_2163	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M483_2166	COG0625	glutathione transferase activity
M483_2167	COG2969	positive regulation of protein catabolic process
M483_2169	COG0493	'glutamate synthase
M483_2170	COG0067	glutamate synthase
M483_2170	COG0069	glutamate synthase activity
M483_2170	COG0070	glutamate synthase
M483_2171	COG1242	4 iron, 4 sulfur cluster binding
M483_2172	COG5002	protein histidine kinase activity
M483_2172	COG2198	Histidine kinase
M483_2172	COG0784	Response regulator, receiver
M483_2173	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M483_2175	COG2823	Periplasmic or secreted lipoprotein
M483_2179	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M483_218	COG1028	Short-chain dehydrogenase reductase Sdr
M483_2180	COG1741	Belongs to the pirin family
M483_2181	COG0583	DNA-binding transcription factor activity
M483_2182	COG0435	Glutathione S-transferase
M483_2183	COG2259	Doxx family
M483_2185	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
M483_2186	COG4575	ribosome binding
M483_2189	COG0586	Pfam SNARE associated Golgi protein
M483_2192	COG2271	Major facilitator Superfamily
M483_2193	COG2271	Major facilitator Superfamily
M483_2195	COG0246	Mannitol dehydrogenase
M483_2196	COG2721	sulfolactate sulfo-lyase activity
M483_2199	COG1943	Transposase
M483_2202	COG0673	inositol 2-dehydrogenase activity
M483_2203	COG1451	nucleotide metabolic process
M483_2206	COG0446	pyridine nucleotide-disulphide oxidoreductase
M483_2206	COG1902	pentaerythritol trinitrate reductase activity
M483_2207	COG3247	response to pH
M483_2210	COG4245	von Willebrand factor, type A
M483_2213	COG4245	von Willebrand factor, type A
M483_2214	COG2831	hemolysin activation secretion protein
M483_2215	COG3210	domain, Protein
M483_2217	COG3210	domain, Protein
M483_2219	COG3210	domain, Protein
M483_222	COG1312	Catalyzes the dehydration of D-mannonate
M483_2223	COG3842	ATPase activity
M483_2224	COG3459	Glycosyltransferase 36 associated
M483_2225	COG1609	Transcriptional regulator
M483_2226	COG1653	transport
M483_2228	COG0395	ABC-type sugar transport system, permease component
M483_223	COG0246	Mannitol dehydrogenase
M483_2232	COG1289	transmembrane transporter activity
M483_224	COG2186	Transcriptional regulator
M483_2240	COG0251	oxidation-reduction process
M483_2257	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M483_2258	COG0358	DNA primase activity
M483_226	COG0523	cobalamin synthesis protein
M483_2262	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M483_2265	COG4991	sh3 domain protein
M483_2266	COG3025	triphosphatase activity
M483_2269	COG0531	amino acid
M483_227	COG0671	phosphoesterase, PA-phosphatase related
M483_2273	COG3384	dioxygenase
M483_2274	COG0754	glutathionylspermidine amidase activity
M483_2277	COG1538	Outer membrane efflux protein
M483_2278	COG0494	nUDIX hydrolase
M483_2279	COG3151	Protein conserved in bacteria
M483_228	COG0791	NLP P60 protein
M483_2280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M483_2281	COG3150	esterase
M483_2282	COG0187	DNA topoisomerase II activity
M483_2283	COG0583	DNA-binding transcription factor activity
M483_2284	COG2249	NAD(P)H dehydrogenase (quinone) activity
M483_2285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M483_2286	COG0204	Acyl-transferase
M483_2287	COG2132	Multicopper oxidase
M483_2290	COG0656	L-ascorbic acid biosynthetic process
M483_2291	COG1979	alcohol dehydrogenase
M483_2292	COG2207	Transcriptional regulator
M483_2293	COG0586	Pfam SNARE associated Golgi protein
M483_2294	COG0626	cystathionine gamma-synthase activity
M483_2295	COG0811	peptide transport
M483_2297	COG0848	biopolymer transport protein
M483_230	COG2200	EAL domain
M483_2307	COG4964	Belongs to the GSP D family
M483_2308	COG4964	Belongs to the GSP D family
M483_231	COG4166	transmembrane transport
M483_2311	COG1943	Transposase
M483_2316	COG4592	Periplasmic binding protein
M483_232	COG4174	ABC transporter (Permease)
M483_2320	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M483_2321	COG1684	flagellar biosynthetic protein fliR
M483_2322	COG1987	bacterial-type flagellum assembly
M483_2326	COG2204	response regulator
M483_233	COG4239	(ABC) transporter, permease
M483_2335	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
M483_2336	COG1815	bacterial-type flagellum-dependent cell motility
M483_2337	COG1558	bacterial-type flagellum-dependent cell motility
M483_2338	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M483_2339	COG1749	Flagellar hook protein flgE
M483_234	COG4172	Belongs to the ABC transporter superfamily
M483_2340	COG4787	bacterial-type flagellum-dependent cell motility
M483_2341	COG4786	Flagellar basal body rod
M483_2342	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M483_2343	COG1706	bacterial-type flagellum-dependent cell motility
M483_2345	COG1256	bacterial-type flagellum assembly
M483_2349	COG3710	Transcriptional regulator
M483_2354	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M483_2359	COG1191	sigma factor activity
M483_236	COG2814	Major facilitator Superfamily
M483_2360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M483_2365	COG3133	Outer membrane lipoprotein
M483_2368	COG2801	Transposase and inactivated derivatives
M483_2369	COG2211	Major facilitator Superfamily
M483_237	COG1187	pseudouridine synthase activity
M483_2379	COG3916	Acyl-homoserine-lactone synthase
M483_238	COG1061	Type III restriction enzyme res subunit
M483_2380	COG2771	luxR family
M483_2398	COG1662	PFAM IS1 transposase
M483_240	COG1943	Transposase
M483_2402	COG1982	Orn Lys Arg decarboxylase major
M483_2403	COG1879	ABC-type sugar transport system periplasmic component
M483_2404	COG1129	ABC transporter
M483_2405	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_2406	COG4774	siderophore transport
M483_2410	COG1194	a g-specific adenine glycosylase
M483_2412	COG3171	Protein conserved in bacteria
M483_2413	COG2066	Belongs to the glutaminase family
M483_2416	COG1073	alpha beta
M483_2416	COG3064	Membrane
M483_2416	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M483_2417	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M483_2418	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M483_242	COG3082	Protein of unknown function (DUF1414)
M483_2420	COG0762	integral membrane protein
M483_2421	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M483_2422	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M483_2423	COG2805	Type II/IV secretion system protein
M483_2425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M483_2428	COG0189	ligase activity
M483_2429	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M483_243	COG3083	sulfuric ester hydrolase activity
M483_2430	COG2356	endonuclease I
M483_2434	COG1166	arginine decarboxylase activity
M483_2436	COG0501	Belongs to the peptidase M48B family
M483_2437	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M483_2438	COG1943	Transposase
M483_2441	COG0191	fructose-bisphosphate aldolase activity
M483_2446	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M483_2447	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M483_2448	COG1943	Transposase
M483_2449	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M483_2452	COG0006	proline dipeptidase activity
M483_2453	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M483_2454	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M483_246	COG3157	Type VI secretion system effector, Hcp
M483_2460	COG5295	Hep Hag repeat protein
M483_2462	COG1272	protein, Hemolysin III
M483_2465	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M483_2466	COG0745	RESPONSE REGULATOR receiver
M483_2467	COG2205	protein histidine kinase activity
M483_2468	COG4452	Inner membrane protein CreD
M483_2469	COG0716	FMN binding
M483_2470	COG4974	Belongs to the 'phage' integrase family
M483_2471	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M483_2472	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M483_2476	COG0582	viral genome integration into host DNA
M483_2481	COG2944	sequence-specific DNA binding
M483_2498	COG1695	Transcriptional regulator
M483_2499	COG0791	NLP P60 protein
M483_25	COG1943	Transposase
M483_250	COG2723	6-phospho-beta-galactosidase activity
M483_2501	COG1879	ABC-type sugar transport system periplasmic component
M483_2502	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_2503	COG1129	ABC transporter
M483_2505	COG2182	Extracellular solute-binding protein
M483_2506	COG1175	transmembrane transport
M483_2507	COG3833	ABC-type maltose transport systems, permease component
M483_2508	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M483_2509	COG1874	Beta-galactosidase
M483_2510	COG1874	Beta-galactosidase
M483_2511	COG1263	PTS System
M483_2511	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M483_2515	COG2271	Major facilitator Superfamily
M483_2519	COG0191	fructose-bisphosphate aldolase activity
M483_252	COG1737	Transcriptional regulator
M483_2521	COG3119	arylsulfatase activity
M483_2522	COG0641	radical SAM
M483_2524	COG1028	Short-chain dehydrogenase reductase Sdr
M483_2526	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M483_2527	COG3716	PTS system mannose fructose sorbose family IID component
M483_2528	COG3715	PTS system
M483_2529	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M483_2530	COG2222	sugar isomerase
M483_2532	COG1349	DNA-binding transcription factor activity
M483_2533	COG3119	arylsulfatase activity
M483_2539	COG0288	reversible hydration of carbon dioxide
M483_2556	COG3328	transposase activity
M483_256	COG3299	homolog of phage Mu protein gp47
M483_2560	COG0840	transmembrane signaling receptor activity
M483_2562	COG0583	DNA-binding transcription factor activity
M483_2563	COG0583	DNA-binding transcription factor activity
M483_2564	COG2814	Major facilitator Superfamily
M483_2565	COG1609	Transcriptional regulator
M483_2566	COG0019	diaminopimelate decarboxylase activity
M483_2572	COG0667	Aldo Keto reductase
M483_2583	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M483_2585	COG1074	ATP-dependent DNA helicase activity
M483_2586	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M483_2590	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M483_2590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M483_2591	COG0860	N-Acetylmuramoyl-L-alanine amidase
M483_2594	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M483_2595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M483_2596	COG2166	iron-sulfur cluster assembly
M483_2597	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M483_2599	COG0583	DNA-binding transcription factor activity
M483_2600	COG2363	Small membrane protein
M483_2602	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M483_2603	COG1611	Belongs to the LOG family
M483_2606	COG1943	Transposase
M483_2607	COG3098	single-species biofilm formation
M483_2608	COG0564	pseudouridine synthase activity
M483_2613	COG0024	Methionine aminopeptidase
M483_2619	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M483_2620	COG0575	Belongs to the CDS family
M483_2621	COG0750	zinc metalloprotease
M483_2623	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M483_2627	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M483_2629	COG0587	DNA-directed DNA polymerase activity
M483_2631	COG0346	lactoylglutathione lyase activity
M483_2632	COG0037	tRNA processing
M483_2634	COG4568	rho-dependent transcription termination
M483_2636	COG4681	YaeQ
M483_2638	COG3015	lipoprotein NlpE involved in copper resistance
M483_2640	COG1720	tRNA m6t6A37 methyltransferase activity
M483_2642	COG1464	Belongs to the NlpA lipoprotein family
M483_2643	COG2011	ABC-type metal ion transport system permease component
M483_2645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M483_265	COG4386	tail sheath protein
M483_2651	COG0656	L-ascorbic acid biosynthetic process
M483_2654	COG1388	LysM domain
M483_2654	COG0741	lytic transglycosylase activity
M483_2656	COG2226	methyltransferase
M483_2658	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M483_2660	COG1953	Uracil, thiamine, allantoin
M483_2662	COG2113	Glycine betaine
M483_2663	COG4176	ABC-type proline glycine betaine transport system permease component
M483_2664	COG4175	Glycine betaine
M483_2665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M483_2673	COG1278	Cold shock
M483_2674	COG0747	negative chemotaxis
M483_2676	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M483_2677	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M483_2678	COG1124	(ABC) transporter
M483_2685	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M483_2687	COG4413	Urea transporter
M483_2688	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M483_269	COG3622	Belongs to the hyi family
M483_2690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M483_2691	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M483_2692	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M483_2693	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M483_2694	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M483_2695	COG1447	Phosphotransferase system cellobiose-specific component IIA
M483_2696	COG2169	Transcriptional regulator
M483_2696	COG1917	Cupin 2, conserved barrel domain protein
M483_27	COG0516	GMP reductase activity
M483_27	COG0517	IMP dehydrogenase activity
M483_270	COG1349	DNA-binding transcription factor activity
M483_2700	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M483_2701	COG0033	Phosphoglucomutase
M483_2705	COG0745	RESPONSE REGULATOR receiver
M483_2706	COG2205	protein histidine kinase activity
M483_2707	COG2205	protein histidine kinase activity
M483_271	COG0235	Class ii aldolase
M483_2712	COG3272	Protein of unknown function (DUF1722)
M483_2714	COG5212	phosphodiesterase
M483_2715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M483_2717	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M483_2718	COG1984	allophanate hydrolase subunit 2
M483_272	COG3395	kinase activity
M483_2729	COG0513	Belongs to the DEAD box helicase family
M483_2731	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M483_2733	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
M483_2734	COG3026	antisigma factor binding
M483_2735	COG3086	response to oxidative stress
M483_2738	COG0681	Belongs to the peptidase S26 family
M483_2742	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M483_2744	COG1943	Transposase
M483_2745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M483_2748	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M483_2751	COG1067	ATP-dependent peptidase activity
M483_2753	COG1943	Transposase
M483_2754	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M483_2754	COG2885	chlorophyll binding
M483_2756	COG3070	regulator of competence-specific genes
M483_2757	COG1289	transmembrane transporter activity
M483_2758	COG3304	Inner membrane component domain
M483_2759	COG0210	DNA helicase
M483_2761	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M483_2762	COG1832	CoA-binding protein
M483_2766	COG2920	part of a sulfur-relay system
M483_2773	COG1028	Short-chain dehydrogenase reductase Sdr
M483_2775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M483_2776	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M483_2777	COG1028	Short-chain dehydrogenase reductase Sdr
M483_2778	COG3425	synthase
M483_2780	COG1024	Enoyl-CoA hydratase
M483_2781	COG1028	Short-chain dehydrogenase reductase Sdr
M483_2783	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M483_2784	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M483_281	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M483_2811	COG0488	(ABC) transporter
M483_2814	COG0303	'Molybdopterin
M483_2816	COG1136	(ABC) transporter
M483_2822	COG0583	DNA-binding transcription factor activity
M483_2823	COG0477	Major facilitator Superfamily
M483_2825	COG2311	Membrane
M483_2828	COG4211	Belongs to the binding-protein-dependent transport system permease family
M483_2832	COG2949	membrane
M483_2835	COG1346	cytolysis
M483_2837	COG2814	Major facilitator Superfamily
M483_284	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M483_2841	COG1943	Transposase
M483_2843	COG0489	protein tyrosine kinase activity
M483_2846	COG2982	Protein involved in outer membrane biogenesis
M483_2847	COG1253	flavin adenine dinucleotide binding
M483_2848	COG4114	ferric iron reductase
M483_2849	COG0076	glutamate decarboxylase activity
M483_2850	COG3486	L-lysine 6-monooxygenase (NADPH) activity
M483_2853	COG1120	ATPase activity
M483_2854	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M483_2855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M483_2856	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M483_2859	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M483_286	COG2223	nitrite transmembrane transporter activity
M483_2860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M483_2862	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M483_2862	COG0140	phosphoribosyl-ATP diphosphatase activity
M483_2865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M483_2866	COG0131	Imidazoleglycerol-phosphate dehydratase
M483_2866	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M483_2868	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M483_287	COG2223	nitrite transmembrane transporter activity
M483_2870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M483_2872	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_2873	COG1129	ABC transporter
M483_2874	COG1129	ABC transporter
M483_2875	COG0371	Dehydrogenase
M483_2877	COG0531	amino acid
M483_2878	COG2925	Exonuclease
M483_288	COG2198	Histidine kinase
M483_288	COG0642	Histidine kinase
M483_2881	COG1470	cell adhesion involved in biofilm formation
M483_2881	COG1388	LysM domain
M483_2882	COG3328	transposase activity
M483_2883	COG2271	Major facilitator Superfamily
M483_2884	COG3011	Protein conserved in bacteria
M483_2885	COG1028	Short-chain dehydrogenase reductase Sdr
M483_2887	COG4948	Mandelate Racemase Muconate Lactonizing
M483_289	COG0642	Histidine kinase
M483_289	COG2198	Histidine kinase
M483_2891	COG0534	Mate efflux family protein
M483_2895	COG3122	Protein conserved in bacteria
M483_29	COG1645	bacterial-type flagellum-dependent swarming motility
M483_2900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M483_2905	COG2223	nitrite transmembrane transporter activity
M483_291	COG2205	protein histidine kinase activity
M483_291	COG0784	Response regulator, receiver
M483_2911	COG1943	Transposase
M483_2912	COG1132	(ABC) transporter
M483_2914	COG2207	Transcriptional regulator
M483_2921	COG1113	amino acid transport
M483_2924	COG1278	Cold shock
M483_2926	COG2226	methyltransferase
M483_2928	COG3447	MASE1 domain protein
M483_2928	COG5001	Diguanylate cyclase
M483_2928	COG5002	protein histidine kinase activity
M483_2932	COG3716	PTS system mannose fructose sorbose family IID component
M483_2933	COG3715	PTS system
M483_2934	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M483_2934	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M483_2935	COG1253	flavin adenine dinucleotide binding
M483_2936	COG1846	Transcriptional regulator
M483_2939	COG1012	belongs to the aldehyde dehydrogenase family
M483_2940	COG3384	dioxygenase
M483_2942	COG3971	2-oxopent-4-enoate hydratase activity
M483_2945	COG2368	4-hydroxyphenylacetate
M483_2946	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M483_2947	COG1760	l-serine dehydratase
M483_2952	COG0513	Belongs to the DEAD box helicase family
M483_2953	COG3141	response to X-ray
M483_2956	COG1770	oligopeptidase
M483_2959	COG1528	Iron-storage protein
M483_296	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M483_2960	COG2372	response to copper ion
M483_2965	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M483_2966	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M483_2969	COG1943	Transposase
M483_2971	COG3418	PFAM FlgN family protein
M483_2972	COG2747	anti-sigma28 factor FlgM
M483_2974	COG1815	bacterial-type flagellum-dependent cell motility
M483_2975	COG1558	bacterial-type flagellum-dependent cell motility
M483_2976	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M483_2977	COG1749	Flagellar hook protein flgE
M483_2979	COG4786	Flagellar basal body rod
M483_2983	COG1256	bacterial-type flagellum assembly
M483_2985	COG2390	Transcriptional regulator
M483_2986	COG1028	Short-chain dehydrogenase reductase Sdr
M483_2986	COG3347	Dehydrogenase
M483_2987	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_2989	COG1129	ABC transporter
M483_299	COG0814	amino acid
M483_2990	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_2991	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M483_2995	COG1987	bacterial-type flagellum assembly
M483_3000	COG1580	Controls the rotational direction of flagella during chemotaxis
M483_3002	COG2882	bacterial-type flagellum organization
M483_3003	COG1157	protein secretion by the type III secretion system
M483_3005	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M483_3007	COG1677	Flagellar hook-basal body complex protein FliE
M483_3010	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M483_3011	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M483_3017	COG1191	sigma factor activity
M483_3019	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M483_3026	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M483_3026	COG0506	proline dehydrogenase activity
M483_3026	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M483_3031	COG2837	iron assimilation
M483_3034	COG1113	amino acid transport
M483_3038	COG3136	membrane protein required for alginate biosynthesis
M483_304	COG0697	spore germination
M483_3040	COG2197	response regulator
M483_306	COG1982	Orn Lys Arg decarboxylase major
M483_3063	COG3328	transposase activity
M483_3064	COG3328	transposase activity
M483_307	COG3328	transposase activity
M483_3071	COG0673	inositol 2-dehydrogenase activity
M483_3073	COG1175	transmembrane transport
M483_3074	COG0395	ABC-type sugar transport system, permease component
M483_308	COG1982	Orn Lys Arg decarboxylase major
M483_3087	COG4771	TonB-dependent receptor
M483_3088	COG1021	2,3-dihydroxybenzoate-AMP ligase
M483_309	COG0531	amino acid
M483_3092	COG2226	methyltransferase
M483_3092	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M483_3092	COG3433	isochorismatase activity
M483_3095	COG1132	(ABC) transporter
M483_3096	COG2814	Major facilitator Superfamily
M483_3097	COG1169	isochorismate synthase
M483_3098	COG0582	viral genome integration into host DNA
M483_310	COG1174	glycine betaine transport
M483_3101	COG3328	transposase activity
M483_3102	COG3121	Chaperone
M483_3104	COG3188	usher protein
M483_3107	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M483_3107	COG2205	protein histidine kinase activity
M483_311	COG1125	glycine betaine transport
M483_3110	COG0427	acetyl-CoA hydrolase
M483_3111	COG2030	dehydratase
M483_3119	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M483_312	COG1174	glycine betaine transport
M483_3120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M483_3122	COG1349	DNA-binding transcription factor activity
M483_3123	COG2066	Belongs to the glutaminase family
M483_3126	COG0672	)-iron permease
M483_3129	COG0577	efflux transmembrane transporter activity
M483_3129	COG1136	(ABC) transporter
M483_313	COG1732	Glycine betaine
M483_3131	COG1136	(ABC) transporter
M483_3131	COG0577	efflux transmembrane transporter activity
M483_3135	COG0006	proline dipeptidase activity
M483_3136	COG0457	Tetratricopeptide repeat
M483_3137	COG0726	polysaccharide deacetylase
M483_3137	COG1649	PFAM Uncharacterised BCR, COG1649
M483_3138	COG1215	transferase activity, transferring glycosyl groups
M483_3139	COG3658	cytochrome
M483_314	COG2897	thiosulfate sulfurtransferase activity
M483_3142	COG1702	phosphate starvation-inducible protein PhoH
M483_3143	COG0387	Pfam Sodium calcium exchanger
M483_3145	COG3850	Histidine kinase
M483_3146	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M483_3155	COG3328	transposase activity
M483_3162	COG0402	S-adenosylhomocysteine deaminase activity
M483_3165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M483_3166	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M483_3167	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M483_317	COG0410	ABC transporter
M483_3176	COG3328	transposase activity
M483_318	COG1122	ATPase activity
M483_3181	COG0500	methyltransferase
M483_3190	COG5002	protein histidine kinase activity
M483_3194	COG0745	RESPONSE REGULATOR receiver
M483_32	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M483_3204	COG0012	GTP binding
M483_3207	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M483_3212	COG2890	protein-(glutamine-N5) methyltransferase activity
M483_3213	COG3094	Invasion gene expression up-regulator, SirB
M483_3214	COG2912	Transglutaminase-like superfamily
M483_3216	COG0659	secondary active sulfate transmembrane transporter activity
M483_322	COG4807	Protein conserved in bacteria
M483_3220	COG3833	ABC-type maltose transport systems, permease component
M483_3221	COG1176	ABC-type spermidine putrescine transport system, permease component I
M483_3223	COG1943	Transposase
M483_3224	COG3842	ATPase activity
M483_3225	COG0584	glycerophosphoryl diester phosphodiesterase
M483_3226	COG1940	carbohydrate kinase activity
M483_3229	COG3381	protein complex oligomerization
M483_3232	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M483_3233	COG0673	inositol 2-dehydrogenase activity
M483_3234	COG0728	peptidoglycan biosynthetic process
M483_3238	COG3102	Protein conserved in bacteria
M483_3242	COG3788	relative of glutathione S-transferase, MAPEG superfamily
M483_3243	COG1801	Protein of unknown function DUF72
M483_3245	COG0494	nUDIX hydrolase
M483_325	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
M483_3250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M483_3252	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M483_3253	COG0739	heme binding
M483_3254	COG1560	Kdo2-lipid A biosynthetic process
M483_3255	COG0469	pyruvate kinase activity
M483_3256	COG1737	Transcriptional regulator
M483_3257	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M483_3259	COG0800	Aldolase
M483_3262	COG0251	oxidation-reduction process
M483_3263	COG1199	ATP-dependent helicase activity
M483_3265	COG3065	identical protein binding
M483_3266	COG0318	PFAM AMP-dependent synthetase and ligase
M483_3267	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M483_3268	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M483_3269	COG2894	cell division
M483_327	COG2261	transglycosylase associated protein
M483_3272	COG2951	lytic endotransglycosylase activity
M483_3273	COG0179	Fumarylacetoacetate (FAA) hydrolase
M483_3275	COG0582	viral genome integration into host DNA
M483_329	COG1403	HNH endonuclease
M483_33	COG2976	Protein conserved in bacteria
M483_3309	COG1943	Transposase
M483_331	COG0277	FAD linked oxidase domain protein
M483_332	COG1686	Belongs to the peptidase S11 family
M483_3327	COG1104	cysteine desulfurase activity
M483_3333	COG2719	SpoVR family
M483_3335	COG2814	Major facilitator Superfamily
M483_3337	COG0583	DNA-binding transcription factor activity
M483_334	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M483_3340	COG2766	serine protein kinase
M483_3341	COG3713	MltA-interacting MipA family protein
M483_3345	COG3139	Protein of unknown function (DUF1315)
M483_3346	COG1335	isochorismatase
M483_3347	COG0252	asparaginase activity
M483_3348	COG0616	signal peptide processing
M483_3349	COG0778	Nitroreductase
M483_3350	COG0709	Synthesizes selenophosphate from selenide and ATP
M483_3351	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M483_3353	COG0494	nUDIX hydrolase
M483_3354	COG0708	Exodeoxyribonuclease III
M483_3355	COG0583	DNA-binding transcription factor activity
M483_3358	COG0788	formyltetrahydrofolate deformylase activity
M483_336	COG1943	Transposase
M483_3360	COG0745	RESPONSE REGULATOR receiver
M483_3362	COG3328	transposase activity
M483_3364	COG1435	thymidine kinase activity
M483_3365	COG1454	alcohol dehydrogenase
M483_3365	COG1012	belongs to the aldehyde dehydrogenase family
M483_3366	COG2095	MarC family integral membrane protein
M483_3368	COG0601	transmembrane transport
M483_3369	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M483_337	COG2211	Major facilitator Superfamily
M483_3370	COG0444	Belongs to the ABC transporter superfamily
M483_3371	COG4608	Belongs to the ABC transporter superfamily
M483_3378	COG2350	Protein conserved in bacteria
M483_338	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M483_3380	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M483_3381	COG3328	transposase activity
M483_3382	COG1607	acyl-coa hydrolase
M483_3387	COG3047	cAMP biosynthetic process
M483_3391	COG0134	indole-3-glycerol-phosphate synthase activity
M483_3391	COG0135	phosphoribosylanthranilate isomerase activity
M483_3393	COG0512	Glutamine amidotransferase of anthranilate synthase
M483_3396	COG0009	L-threonylcarbamoyladenylate synthase
M483_3397	COG1187	pseudouridine synthase activity
M483_3399	COG1028	Short-chain dehydrogenase reductase Sdr
M483_340	COG0583	DNA-binding transcription factor activity
M483_3400	COG0616	signal peptide processing
M483_3403	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M483_3405	COG0583	DNA-binding transcription factor activity
M483_3407	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M483_3408	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M483_3409	COG0671	phosphoesterase, PA-phosphatase related
M483_341	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M483_3410	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M483_3411	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M483_3414	COG0023	Translation Initiation Factor
M483_3418	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M483_3419	COG2879	small protein
M483_3420	COG1966	Carbon starvation protein
M483_3422	COG2271	Major facilitator Superfamily
M483_3423	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M483_3424	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M483_3426	COG4659	FMN binding
M483_3427	COG4658	electron transport chain
M483_3428	COG2207	Transcriptional regulator
M483_3428	COG3708	Transcriptional regulator
M483_3434	COG1132	(ABC) transporter
M483_3436	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M483_3437	COG2274	protein secretion by the type I secretion system
M483_3441	COG1879	ABC-type sugar transport system periplasmic component
M483_3443	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_3444	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_3446	COG0673	inositol 2-dehydrogenase activity
M483_3447	COG0385	Bile acid
M483_3449	COG5339	Protein conserved in bacteria
M483_3451	COG0114	fumarate hydratase activity
M483_3453	COG2814	Major facilitator Superfamily
M483_3454	COG0583	DNA-binding transcription factor activity
M483_3455	COG1940	carbohydrate kinase activity
M483_3457	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M483_3458	COG0038	chloride channel
M483_346	COG0670	Belongs to the BI1 family
M483_3460	COG1609	Transcriptional regulator
M483_3462	COG1879	ABC-type sugar transport system periplasmic component
M483_3463	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M483_3464	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M483_3466	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M483_347	COG0314	molybdopterin synthase activity
M483_3472	COG0028	Belongs to the TPP enzyme family
M483_3473	COG0440	acetolactate synthase activity
M483_3474	COG1011	Hydrolase
M483_3477	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M483_3478	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M483_3479	COG0589	response to stress
M483_348	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M483_3480	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M483_3481	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M483_3483	COG0531	amino acid
M483_3485	COG0745	RESPONSE REGULATOR receiver
M483_3486	COG2205	protein histidine kinase activity
M483_3487	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M483_3488	COG1943	Transposase
M483_3492	COG3038	cytochrome b561
M483_3494	COG3591	Belongs to the peptidase S1B family
M483_3497	COG1643	Atp-dependent helicase
M483_3499	COG2390	Transcriptional regulator
M483_350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M483_3500	COG0246	Mannitol dehydrogenase
M483_3501	COG3784	Protein of unknown function (DUF1318)
M483_3503	COG2911	Protein conserved in bacteria
M483_3504	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M483_3505	COG3187	Heat shock protein
M483_3506	COG3042	response to heat
M483_3507	COG1285	pathogenesis
M483_3509	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M483_3509	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M483_3509	COG1013	pyruvate-flavodoxin oxidoreductase activity
M483_3509	COG0674	pyruvate-flavodoxin oxidoreductase activity
M483_3512	COG2755	lipolytic protein G-D-S-L family
M483_3512	COG0657	acetylesterase activity
M483_3515	COG4166	transmembrane transport
M483_3516	COG2866	Carboxypeptidase
M483_3517	COG4948	Mandelate Racemase Muconate Lactonizing
M483_3518	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M483_352	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M483_3521	COG1943	Transposase
M483_3526	COG3106	COG3106 Predicted ATPase
M483_3528	COG1983	PspC domain protein
M483_353	COG4628	conserved protein (DUF2132)
M483_3530	COG1842	Phage shock protein A
M483_3531	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M483_3533	COG1943	Transposase
M483_3534	COG4166	transmembrane transport
M483_3535	COG4168	peptide transport system, permease
M483_3536	COG4171	peptide transport system, permease
M483_3538	COG4172	Belongs to the ABC transporter superfamily
M483_3539	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M483_3539	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M483_354	COG0556	nucleotide-excision repair
M483_3541	COG3104	oligopeptide transport
M483_3544	COG0625	glutathione transferase activity
M483_3548	COG3895	Periplasmic Protein
M483_3550	COG3133	Outer membrane lipoprotein
M483_3551	COG4989	oxidoreductase activity
M483_3552	COG3313	Fe-S protein
M483_3553	COG2194	sulfuric ester hydrolase activity
M483_3554	COG1309	transcriptional regulator
M483_3555	COG1902	pentaerythritol trinitrate reductase activity
M483_3557	COG0346	lactoylglutathione lyase activity
M483_3559	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M483_356	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M483_3561	COG0791	NLP P60 protein
M483_3562	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M483_3565	COG0583	DNA-binding transcription factor activity
M483_3566	COG2814	Major facilitator Superfamily
M483_3567	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M483_3568	COG0307	riboflavin synthase, alpha
M483_357	COG2226	methyltransferase
M483_3573	COG4238	major outer membrane lipoprotein
M483_3574	COG1943	Transposase
M483_3578	COG1376	ErfK ybiS ycfS ynhG family protein
M483_3578	COG1388	LysM domain
M483_3581	COG0719	Fe-S assembly protein
M483_3582	COG0396	ATPase activity
M483_3583	COG0719	Fe-S assembly protein
M483_3584	COG0316	Belongs to the HesB IscA family
M483_3585	COG2050	protein possibly involved in aromatic compounds catabolism
M483_3586	COG0247	lactate metabolic process
M483_3586	COG0277	FAD linked oxidase domain protein
M483_3587	COG0628	permease
M483_3588	COG0574	Belongs to the PEP-utilizing enzyme family
M483_3588	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M483_3593	COG0791	NLP P60 protein
M483_3601	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
M483_3602	COG0386	Belongs to the glutathione peroxidase family
M483_3605	COG0776	regulation of translation
M483_3606	COG0072	phenylalanine-tRNA ligase activity
M483_3606	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M483_3607	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M483_3612	COG4249	Peptidase C14 caspase catalytic subunit p20
M483_3616	COG0803	Belongs to the bacterial solute-binding protein 9 family
M483_3617	COG1121	(ABC) transporter
M483_3618	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M483_3619	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M483_362	COG0561	phosphatase activity
M483_3622	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M483_3623	COG3328	transposase activity
M483_3624	COG1917	Cupin 2, conserved barrel domain protein
M483_3626	COG1028	Short-chain dehydrogenase reductase Sdr
M483_3628	COG1175	transmembrane transport
M483_3629	COG0395	ABC-type sugar transport system, permease component
M483_3630	COG3842	ATPase activity
M483_3631	COG1653	transport
M483_3632	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M483_3633	COG1988	membrane-bound metal-dependent
M483_3635	COG3023	N-Acetylmuramoyl-L-alanine amidase
M483_3637	COG0823	Involved in the tonB-independent uptake of proteins
M483_3638	COG2814	Major facilitator Superfamily
M483_3639	COG3121	Chaperone
M483_364	COG4149	molybdate abc transporter
M483_3642	COG3121	Chaperone
M483_3643	COG3539	Fimbrial protein
M483_3646	COG0793	Belongs to the peptidase S41A family
M483_3648	COG1956	GAF domain-containing protein
M483_3649	COG2995	paraquat-inducible protein a
M483_365	COG0725	ABC transporter, periplasmic molybdate-binding protein
M483_3650	COG3008	intermembrane lipid transfer
M483_3654	COG3121	Chaperone
M483_3666	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M483_3669	COG5295	Hep Hag repeat protein
M483_367	COG2005	Transcriptional regulator
M483_367	COG3585	molybdate ion transport
M483_3671	COG3023	N-Acetylmuramoyl-L-alanine amidase
M483_3672	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M483_3673	COG0745	RESPONSE REGULATOR receiver
M483_3675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M483_3676	COG0840	transmembrane signaling receptor activity
M483_3677	COG0840	transmembrane signaling receptor activity
M483_368	COG1119	ATPase activity
M483_3681	COG2964	Protein conserved in bacteria
M483_3683	COG0251	oxidation-reduction process
M483_3684	COG2271	Major facilitator Superfamily
M483_3685	COG0835	chemotaxis
M483_3686	COG2198	Histidine kinase
M483_3686	COG0643	Histidine kinase
M483_3687	COG1360	Flagellar Motor Protein
M483_3692	COG1285	pathogenesis
M483_3693	COG0840	transmembrane signaling receptor activity
M483_3694	COG0840	transmembrane signaling receptor activity
M483_3696	COG1278	Cold shock
M483_3698	COG1028	Short-chain dehydrogenase reductase Sdr
M483_3698	COG0604	alcohol dehydrogenase
M483_3698	COG3321	synthase
M483_3700	COG1522	sequence-specific DNA binding
M483_3705	COG1733	regulation of RNA biosynthetic process
M483_3706	COG0702	epimerase
M483_3707	COG0840	transmembrane signaling receptor activity
M483_3710	COG0538	isocitrate dehydrogenase activity
M483_3711	COG1187	pseudouridine synthase activity
M483_3715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M483_3717	COG0745	RESPONSE REGULATOR receiver
M483_3719	COG2850	peptidyl-arginine hydroxylation
M483_372	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M483_3721	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M483_3723	COG4591	ABC-type transport system involved in lipoprotein release permease component
M483_3725	COG4591	ABC-type transport system involved in lipoprotein release permease component
M483_3726	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M483_3727	COG3134	Outer membrane lipoprotein
M483_3728	COG3328	transposase activity
M483_373	COG1085	galactose-1-phosphate uridylyltransferase
M483_3731	COG1252	NADH dehydrogenase
M483_3733	COG1472	Belongs to the glycosyl hydrolase 3 family
M483_3736	COG5633	Lipoprotein
M483_3737	COG0537	adenosine 5'-monophosphoramidase activity
M483_3738	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M483_3739	COG1943	Transposase
M483_3740	COG1263	PTS System
M483_3740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M483_3741	COG0084	hydrolase, TatD family'
M483_3742	COG0470	DNA polymerase III
M483_3744	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M483_3745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M483_3746	COG1943	Transposase
M483_3747	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M483_3749	COG1028	Short-chain dehydrogenase reductase Sdr
M483_3753	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M483_3754	COG1399	metal-binding, possibly nucleic acid-binding protein
M483_3756	COG0564	pseudouridine synthase activity
M483_3757	COG1530	ribonuclease E activity
M483_3758	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M483_376	COG2017	converts alpha-aldose to the beta-anomer
M483_3761	COG3328	transposase activity
M483_3765	COG0628	permease
M483_3769	COG2771	luxR family
M483_3770	COG3916	Acyl-homoserine-lactone synthase
M483_3771	COG0583	DNA-binding transcription factor activity
M483_3773	COG0477	Major facilitator Superfamily
M483_3775	COG0667	Aldo Keto reductase
M483_3780	COG1203	CRISPR-associated helicase, Cas3
M483_3781	COG1518	maintenance of DNA repeat elements
M483_3782	COG0668	transmembrane transport
M483_3786	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
M483_3787	COG0395	ABC-type sugar transport system, permease component
M483_379	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M483_3790	COG1609	Transcriptional regulator
M483_3792	COG3842	ATPase activity
M483_3793	COG3328	transposase activity
M483_3795	COG3210	domain, Protein
M483_3799	COG3210	domain, Protein
M483_380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M483_3802	COG3210	domain, Protein
M483_3803	COG2831	hemolysin activation secretion protein
M483_3804	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M483_3805	COG4638	Rieske (2fe-2S)
M483_3806	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M483_3807	COG0473	3-isopropylmalate dehydrogenase activity
M483_3808	COG0583	DNA-binding transcription factor activity
M483_3809	COG1609	Transcriptional regulator
M483_381	COG1230	cation diffusion facilitator family transporter
M483_3810	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_3811	COG1129	ABC transporter
M483_3813	COG1879	ABC-type sugar transport system periplasmic component
M483_3814	COG1063	alcohol dehydrogenase
M483_3818	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M483_3824	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M483_3825	COG0765	amino acid transport
M483_3826	COG1126	abc transporter atp-binding protein
M483_3830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M483_3833	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M483_3836	COG1169	isochorismate synthase
M483_3838	COG4575	ribosome binding
M483_3840	COG0129	dihydroxy-acid dehydratase activity
M483_3843	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M483_3844	COG1609	Transcriptional regulator
M483_3846	COG1028	Short-chain dehydrogenase reductase Sdr
M483_3847	COG3265	gluconokinase activity
M483_3848	COG2731	YhcH YjgK YiaL family protein
M483_3851	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M483_3852	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M483_3854	COG0839	Belongs to the complex I subunit 6 family
M483_3857	COG1034	ATP synthesis coupled electron transport
M483_3859	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M483_3861	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M483_3863	COG0583	DNA-binding transcription factor activity
M483_3864	COG0436	Aminotransferase
M483_3866	COG0471	metal ion transport
M483_3866	COG0490	domain, Protein
M483_3867	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M483_3871	COG0280	phosphate acetyltransferase
M483_3871	COG0857	belongs to the CobB CobQ family
M483_3872	COG1609	Transcriptional regulator
M483_3875	COG3037	sugar-specific permease SgaT UlaA
M483_3876	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M483_3877	COG0622	Phosphoesterase
M483_3878	COG0622	Phosphoesterase
M483_388	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M483_3880	COG1090	epimerase
M483_3881	COG4598	ABC transporter
M483_3882	COG4160	amino acid transport
M483_3883	COG4215	(ABC) transporter
M483_3884	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M483_3885	COG0163	prenyltransferase activity
M483_3886	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M483_3887	COG1286	toxin biosynthetic process
M483_3888	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M483_3889	COG0285	dihydrofolate synthase activity
M483_389	COG2885	chlorophyll binding
M483_3891	COG0586	Pfam SNARE associated Golgi protein
M483_3893	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M483_3896	COG0697	spore germination
M483_3899	COG1794	racemase activity, acting on amino acids and derivatives
M483_3900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M483_3903	COG3101	peptidyl-lysine hydroxylation
M483_3904	COG0730	response to heat
M483_3907	COG2890	protein-(glutamine-N5) methyltransferase activity
M483_3909	COG2062	phosphohistidine phosphatase, SixA
M483_391	COG3064	Membrane
M483_391	COG3064	Membrane
M483_3912	COG3691	Protein conserved in bacteria
M483_3915	COG3088	subunit of a heme lyase
M483_3915	COG4235	cytochrome complex assembly
M483_3916	COG3088	subunit of a heme lyase
M483_3916	COG4235	cytochrome complex assembly
M483_3917	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M483_3918	COG1138	Cytochrome C-type biogenesis protein
M483_392	COG0848	biopolymer transport protein
M483_3920	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M483_3921	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M483_3922	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M483_3926	COG1704	LemA family
M483_3928	COG2824	Alkylphosphonate utilization operon protein PhnA
M483_393	COG0811	peptide transport
M483_3934	COG3501	Rhs element vgr protein
M483_394	COG0824	Thioesterase
M483_3947	COG3188	usher protein
M483_3948	COG3328	transposase activity
M483_3949	COG3328	transposase activity
M483_395	COG3790	cyd operon protein YbgE
M483_3950	COG3188	usher protein
M483_3951	COG3121	Chaperone
M483_396	COG4890	Cyd operon protein YbgT
M483_3963	COG2951	lytic endotransglycosylase activity
M483_397	COG1294	oxidase, subunit
M483_3970	COG0243	molybdopterin cofactor binding
M483_3971	COG0437	4 iron, 4 sulfur cluster binding
M483_3972	COG3302	dmso reductase anchor subunit
M483_3973	COG3381	protein complex oligomerization
M483_3979	COG3038	cytochrome b561
M483_398	COG1271	oxidase subunit
M483_3980	COG0436	Aminotransferase
M483_3985	COG0667	Aldo Keto reductase
M483_3988	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M483_399	COG1943	Transposase
M483_3995	COG1943	Transposase
M483_3998	COG3530	Putative quorum-sensing-regulated virulence factor
M483_400	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M483_4001	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M483_4002	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M483_4003	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M483_4005	COG2190	(PTS) system
M483_4008	COG2205	protein histidine kinase activity
M483_4009	COG0745	RESPONSE REGULATOR receiver
M483_4010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M483_4013	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M483_4015	COG0006	proline dipeptidase activity
M483_4017	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M483_4019	COG3850	Histidine kinase
M483_4019	COG5002	protein histidine kinase activity
M483_402	COG0508	dehydrogenase complex catalyzes the overall conversion of
M483_4020	COG0745	RESPONSE REGULATOR receiver
M483_4023	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M483_4024	COG4208	sulfate ABC transporter
M483_4025	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M483_4026	COG4150	thiosulfate binding
M483_4028	COG1737	Transcriptional regulator
M483_4029	COG2731	YhcH YjgK YiaL family protein
M483_403	COG0567	Dehydrogenase, E1 component
M483_4031	COG4886	Leucine-rich repeat (LRR) protein
M483_4033	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M483_4034	COG2837	iron assimilation
M483_4037	COG3111	PFAM Bacterial OB fold (BOF) protein
M483_4046	COG3005	denitrification pathway
M483_4047	COG3043	anaerobic respiration
M483_4049	COG3062	negative regulation of establishment of protein localization
M483_405	COG1053	succinate dehydrogenase
M483_4050	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
M483_4050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M483_4051	COG2197	response regulator
M483_4053	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M483_4055	COG1988	membrane-bound metal-dependent
M483_4056	COG0641	radical SAM
M483_4057	COG3119	arylsulfatase activity
M483_4058	COG3842	ATPase activity
M483_4059	COG1175	transmembrane transport
M483_406	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M483_4060	COG1840	ABC-type Fe3 transport system, periplasmic component
M483_4062	COG1393	Belongs to the ArsC family
M483_4064	COG1876	peptidase activity
M483_4068	COG2321	neutral zinc metallopeptidase
M483_407	COG2009	succinate dehydrogenase
M483_4070	COG1943	Transposase
M483_4071	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M483_4073	COG2716	regulation of RNA biosynthetic process
M483_4074	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M483_4077	COG0628	permease
M483_4078	COG4783	chaperone-mediated protein folding
M483_4079	COG1393	Belongs to the ArsC family
M483_4081	COG1943	Transposase
M483_4084	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M483_4085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M483_4089	COG0581	inorganic phosphate transmembrane transporter activity
M483_4091	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M483_4092	COG0248	Ppx GppA phosphatase
M483_4093	COG2239	Acts as a magnesium transporter
M483_4094	COG0443	Heat shock 70 kDa protein
M483_4095	COG1177	transmembrane transport
M483_4096	COG1176	ABC-type spermidine putrescine transport system, permease component I
M483_4098	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M483_4099	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M483_41	COG3468	outer membrane autotransporter barrel domain protein
M483_410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M483_4100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M483_4104	COG1943	Transposase
M483_4108	COG1943	Transposase
M483_411	COG0497	DNA recombination
M483_4117	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M483_4118	COG1475	DNA binding
M483_4119	COG1475	DNA binding
M483_412	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M483_4137	COG3941	tape measure
M483_414	COG2867	negative regulation of translational initiation
M483_4144	COG5301	cellulose 1,4-beta-cellobiosidase activity
M483_4144	COG5301	cellulose 1,4-beta-cellobiosidase activity
M483_4145	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M483_4148	COG1475	DNA binding
M483_416	COG1943	Transposase
M483_4165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M483_417	COG0582	viral genome integration into host DNA
M483_4171	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M483_4171	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M483_4176	COG3328	transposase activity
M483_4199	COG3328	transposase activity
M483_42	COG3468	outer membrane autotransporter barrel domain protein
M483_4200	COG3328	transposase activity
M483_4224	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M483_4226	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M483_4247	COG2801	Transposase and inactivated derivatives
M483_4251	COG2801	Transposase and inactivated derivatives
M483_4253	COG5599	Phosphatase
M483_4255	COG3609	addiction module antidote protein, CC2985 family
M483_4257	COG1475	DNA binding
M483_4258	COG1192	Involved in chromosome partitioning
M483_4260	COG2801	Transposase and inactivated derivatives
M483_4264	COG3177	Filamentation induced by cAMP protein fic
M483_4269	COG4886	Leucine-rich repeat (LRR) protein
M483_427	COG3657	addiction module killer protein
M483_4271	COG3328	transposase activity
M483_4274	COG0457	Tetratricopeptide repeat
M483_4278	COG4789	Type iii secretion
M483_4287	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M483_4288	COG4790	Type iii secretion
M483_4289	COG4794	Type iii secretion
M483_4290	COG4791	protein targeting
M483_4291	COG4792	protein secretion
M483_4293	COG2207	Transcriptional regulator
M483_4302	COG4669	(LipO)protein
M483_4304	COG1317	bacterial-type flagellum organization
M483_4305	COG5599	Phosphatase
M483_4306	COG2963	transposase activity
M483_4307	COG2801	Transposase and inactivated derivatives
M483_431	COG0582	viral genome integration into host DNA
M483_4312	COG2801	Transposase and inactivated derivatives
M483_4314	COG0515	serine threonine protein kinase
M483_432	COG2963	transposase activity
M483_434	COG0596	Alpha beta hydrolase
M483_438	COG0735	belongs to the Fur family
M483_443	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M483_443	COG2190	(PTS) system
M483_443	COG1263	PTS System
M483_445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M483_446	COG1846	Transcriptional regulator
M483_446	COG1940	carbohydrate kinase activity
M483_447	COG0647	UMP catabolic process
M483_448	COG0367	asparagine synthase
M483_455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M483_457	COG1702	phosphate starvation-inducible protein PhoH
M483_459	COG4535	Mg2 and Co2 transporter CorC
M483_46	COG2975	iron-sulfur cluster assembly
M483_460	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M483_462	COG0765	amino acid transport
M483_463	COG0765	amino acid transport
M483_464	COG1126	abc transporter atp-binding protein
M483_465	COG2888	peptidyl-tyrosine sulfation
M483_468	COG1466	dna polymerase III delta subunit
M483_47	COG0633	Ferredoxin
M483_470	COG0799	negative regulation of ribosome biogenesis
M483_472	COG0768	penicillin binding
M483_473	COG0772	Belongs to the SEDS family
M483_474	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M483_475	COG1686	Belongs to the peptidase S11 family
M483_479	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M483_48	COG0443	Heat shock 70 kDa protein
M483_480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M483_481	COG1278	Cold shock
M483_482	COG1278	Cold shock
M483_483	COG2197	response regulator
M483_488	COG5265	(ABC) transporter
M483_490	COG3718	enzyme involved in inositol metabolism
M483_492	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M483_493	COG0673	inositol 2-dehydrogenase activity
M483_494	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_495	COG1129	ABC transporter
M483_496	COG1879	ABC-type sugar transport system periplasmic component
M483_497	COG0673	inositol 2-dehydrogenase activity
M483_498	COG0673	inositol 2-dehydrogenase activity
M483_499	COG3962	Belongs to the TPP enzyme family
M483_505	COG2373	Large extracellular alpha-helical protein
M483_506	COG4953	penicillin-binding protein 1C
M483_507	COG3423	Transcriptional regulator
M483_51	COG0822	iron-sulfur transferase activity
M483_516	COG2850	peptidyl-arginine hydroxylation
M483_517	COG3328	transposase activity
M483_52	COG1104	cysteine desulfurase activity
M483_522	COG0656	L-ascorbic acid biosynthetic process
M483_523	COG0667	Aldo Keto reductase
M483_529	COG2453	phosphatase
M483_529	COG0671	phosphoesterase, PA-phosphatase related
M483_530	COG2267	carboxylic ester hydrolase activity
M483_532	COG4589	Belongs to the CDS family
M483_533	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M483_540	COG2501	S4 domain
M483_541	COG1943	Transposase
M483_544	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M483_546	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M483_547	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M483_548	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M483_549	COG4181	ATPase activity
M483_55	COG0483	inositol monophosphate 1-phosphatase activity
M483_550	COG2755	lipolytic protein G-D-S-L family
M483_551	COG0300	oxidoreductase activity
M483_552	COG3118	belongs to the thioredoxin family
M483_553	COG0330	HflC and HflK could
M483_554	COG1585	Membrane protein implicated in regulation of membrane protease activity
M483_555	COG0789	Transcriptional regulator
M483_556	COG2217	Heavy metal translocating P-type atpase
M483_557	COG3735	TraB family
M483_558	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M483_56	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
M483_561	COG0737	Belongs to the 5'-nucleotidase family
M483_562	COG0737	Belongs to the 5'-nucleotidase family
M483_563	COG0737	Belongs to the 5'-nucleotidase family
M483_564	COG2223	nitrite transmembrane transporter activity
M483_565	COG2223	nitrite transmembrane transporter activity
M483_566	COG4651	solute:proton antiporter activity
M483_566	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M483_567	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M483_568	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M483_57	COG3683	transport system, periplasmic component
M483_572	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M483_573	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
M483_574	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
M483_58	COG2814	Major facilitator Superfamily
M483_582	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M483_586	COG0543	2 iron, 2 sulfur cluster binding
M483_586	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M483_59	COG3711	transcriptional antiterminator
M483_592	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M483_594	COG2832	Protein of unknown function (DUF454)
M483_596	COG1196	nuclear chromosome segregation
M483_596	COG3264	Mechanosensitive ion channel
M483_597	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M483_598	COG1309	transcriptional regulator
M483_599	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M483_600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M483_602	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M483_606	COG3695	enzyme binding
M483_607	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M483_608	COG1946	Acyl-CoA thioesterase
M483_609	COG0004	ammonium transporteR
M483_610	COG0347	Belongs to the P(II) protein family
M483_611	COG1132	(ABC) transporter
M483_612	COG1132	(ABC) transporter
M483_613	COG1522	sequence-specific DNA binding
M483_616	COG4533	DNA binding
M483_618	COG0824	Thioesterase
M483_619	COG1555	photosystem II stabilization
M483_62	COG1017	nitric oxide dioxygenase activity
M483_62	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M483_620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M483_621	COG1943	Transposase
M483_623	COG0776	regulation of translation
M483_624	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M483_629	COG0271	Belongs to the BolA IbaG family
M483_630	COG3056	Lipoprotein
M483_631	COG2223	nitrite transmembrane transporter activity
M483_633	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M483_634	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M483_635	COG1845	cytochrome c oxidase, subunit III
M483_636	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M483_638	COG2814	Major facilitator Superfamily
M483_640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M483_641	COG0693	protein deglycase activity
M483_644	COG0142	geranyltranstransferase activity
M483_646	COG1943	Transposase
M483_647	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M483_648	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M483_651	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M483_651	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M483_655	COG1943	Transposase
M483_656	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M483_657	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M483_658	COG1862	Preprotein translocase
M483_66	COG2188	Transcriptional regulator
M483_660	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M483_661	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M483_662	COG0450	alkyl hydroperoxide reductase
M483_666	COG0366	Alpha amylase catalytic
M483_668	COG1114	Component of the transport system for branched-chain amino acids
M483_67	COG0347	Belongs to the P(II) protein family
M483_670	COG5002	protein histidine kinase activity
M483_671	COG5002	protein histidine kinase activity
M483_672	COG0745	RESPONSE REGULATOR receiver
M483_673	COG0420	3'-5' exonuclease activity
M483_674	COG0419	ATPase involved in DNA repair
M483_675	COG1940	carbohydrate kinase activity
M483_68	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M483_68	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M483_680	COG2226	methyltransferase
M483_69	COG2204	response regulator
M483_691	COG2195	Cleaves the N-terminal amino acid of tripeptides
M483_695	COG1477	protein flavinylation
M483_699	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M483_70	COG3170	Tfp pilus assembly protein FimV
M483_700	COG1805	sodium ion transport
M483_701	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M483_702	COG0121	glutamine amidotransferase
M483_703	COG3034	peptidoglycan biosynthetic process
M483_705	COG1960	acyl-CoA dehydrogenase activity
M483_706	COG1943	Transposase
M483_708	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
M483_71	COG2205	protein histidine kinase activity
M483_716	COG0436	Aminotransferase
M483_719	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M483_72	COG1943	Transposase
M483_722	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M483_731	COG2814	Major facilitator Superfamily
M483_732	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M483_734	COG1846	Transcriptional regulator
M483_735	COG1566	PFAM secretion protein HlyD family protein
M483_736	COG2814	Major facilitator Superfamily
M483_737	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M483_738	COG3118	belongs to the thioredoxin family
M483_740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M483_740	COG0045	succinate-CoA ligase (ADP-forming) activity
M483_740	COG1042	CoA-binding domain protein
M483_741	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M483_742	COG5544	Lipoprotein
M483_754	COG0678	peroxiredoxin activity
M483_754	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M483_755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M483_760	COG1629	transport
M483_764	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M483_768	COG2801	Transposase and inactivated derivatives
M483_773	COG0195	Participates in both transcription termination and antitermination
M483_777	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M483_779	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M483_78	COG0590	tRNA wobble adenosine to inosine editing
M483_780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M483_782	COG1534	Rna-binding protein
M483_783	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M483_784	COG2027	D-alanyl-D-alanine carboxypeptidase
M483_785	COG0745	RESPONSE REGULATOR receiver
M483_786	COG0642	Histidine kinase
M483_788	COG0697	spore germination
M483_79	COG0560	Phosphoserine phosphatase
M483_791	COG0142	geranyltranstransferase activity
M483_793	COG3423	Transcriptional regulator
M483_797	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M483_799	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M483_8	COG2205	protein histidine kinase activity
M483_800	COG2105	PFAM AIG2 family protein
M483_801	COG2911	Protein conserved in bacteria
M483_802	COG0729	surface antigen
M483_804	COG1253	flavin adenine dinucleotide binding
M483_806	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M483_808	COG0737	Belongs to the 5'-nucleotidase family
M483_81	COG1737	Transcriptional regulator
M483_810	COG0545	Peptidyl-prolyl cis-trans isomerase
M483_811	COG3061	Opacity-associated protein A
M483_813	COG1943	Transposase
M483_815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M483_818	COG1073	alpha beta
M483_82	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M483_824	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M483_829	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
M483_83	COG1943	Transposase
M483_830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M483_831	COG1739	Uncharacterized protein family UPF0029
M483_84	COG3009	Protein conserved in bacteria
M483_840	COG0805	protein transport
M483_842	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M483_846	COG1322	Protein conserved in bacteria
M483_847	COG0586	Pfam SNARE associated Golgi protein
M483_848	COG1966	Carbon starvation protein
M483_85	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M483_85	COG3008	intermembrane lipid transfer
M483_850	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M483_851	COG0412	Dienelactone hydrolase
M483_854	COG0583	DNA-binding transcription factor activity
M483_855	COG0679	Auxin Efflux Carrier
M483_856	COG0584	glycerophosphoryl diester phosphodiesterase
M483_86	COG2995	paraquat-inducible protein a
M483_868	COG0410	ABC transporter
M483_869	COG0411	ABC transporter
M483_87	COG0488	(ABC) transporter
M483_870	COG4177	L-phenylalanine transmembrane transporter activity
M483_871	COG0559	Belongs to the binding-protein-dependent transport system permease family
M483_872	COG0683	leucine binding
M483_874	COG1943	Transposase
M483_876	COG2177	Part of the ABC transporter FtsEX involved in
M483_877	COG2884	Cell division ATP-binding protein ftsE
M483_878	COG0552	protein localization to endoplasmic reticulum
M483_878	COG0552	protein localization to endoplasmic reticulum
M483_879	COG0742	ribosomal rna small subunit methyltransferase
M483_880	COG3776	membrane
M483_883	COG3714	YhhN family
M483_886	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M483_888	COG0247	lactate metabolic process
M483_89	COG3217	Mosc domain protein beta barrel domain protein
M483_89	COG0633	Ferredoxin
M483_890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M483_891	COG0584	glycerophosphoryl diester phosphodiesterase
M483_893	COG0561	phosphatase activity
M483_894	COG2267	carboxylic ester hydrolase activity
M483_895	COG1280	lysine exporter protein (LysE YggA)
M483_896	COG1280	lysine exporter protein (LysE YggA)
M483_897	COG0514	ATP-dependent DNA helicase (RecQ)
M483_898	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
M483_899	COG2050	protein possibly involved in aromatic compounds catabolism
M483_9	COG0745	RESPONSE REGULATOR receiver
M483_901	COG0598	Magnesium transport protein CorA
M483_902	COG5564	TIM-barrel signal transduction protein
M483_903	COG5441	Belongs to the UPF0261 family
M483_905	COG0210	DNA helicase
M483_906	COG1011	Hydrolase
M483_907	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M483_908	COG3159	Protein conserved in bacteria
M483_910	COG5567	small periplasmic lipoprotein
M483_912	COG3072	Adenylate cyclase
M483_914	COG1587	Uroporphyrinogen-III synthase
M483_915	COG2959	enzyme of heme biosynthesis
M483_916	COG3071	HemY protein
M483_917	COG1943	Transposase
M483_92	COG0308	aminopeptidase N
M483_923	COG1113	amino acid transport
M483_927	COG2244	polysaccharide biosynthetic process
M483_928	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M483_929	COG0456	acetyltransferase
M483_930	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M483_931	COG1088	dTDP-glucose 4,6-dehydratase activity
M483_932	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M483_933	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M483_934	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M483_935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M483_936	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M483_937	COG3118	belongs to the thioredoxin family
M483_941	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M483_944	COG3121	Chaperone
M483_947	COG3121	Chaperone
M483_954	COG0583	DNA-binding transcription factor activity
M483_96	COG1448	Aminotransferase
M483_962	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M483_963	COG3978	acetolactate synthase activity
M483_966	COG3085	chromosome segregation
M483_967	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_969	COG1172	Belongs to the binding-protein-dependent transport system permease family
M483_97	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M483_970	COG1129	ABC transporter
M483_971	COG1879	ABC-type sugar transport system periplasmic component
M483_98	COG3108	Peptidase M15
M483_981	COG0151	Belongs to the GarS family
M483_984	COG3068	Protein conserved in bacteria
M483_985	COG1515	deoxyribonuclease V activity
M483_99	COG2989	Protein conserved in bacteria
M483_990	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M483_992	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M483_997	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism