locus-tag	class	description
M484_1	COG2814	Major facilitator Superfamily
M484_100	COG0517	IMP dehydrogenase activity
M484_100	COG0516	GMP reductase activity
M484_1001	COG1176	ABC-type spermidine putrescine transport system, permease component I
M484_1002	COG3833	ABC-type maltose transport systems, permease component
M484_1006	COG0659	secondary active sulfate transmembrane transporter activity
M484_1008	COG2912	Transglutaminase-like superfamily
M484_1009	COG3094	Invasion gene expression up-regulator, SirB
M484_1010	COG2890	protein-(glutamine-N5) methyltransferase activity
M484_1015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M484_1018	COG0012	GTP binding
M484_102	COG1943	Transposase
M484_1028	COG0745	RESPONSE REGULATOR receiver
M484_1032	COG5002	protein histidine kinase activity
M484_1041	COG0500	methyltransferase
M484_1046	COG3328	transposase activity
M484_1055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M484_1056	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M484_1057	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M484_1060	COG0402	S-adenosylhomocysteine deaminase activity
M484_1066	COG3328	transposase activity
M484_1075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M484_1076	COG3850	Histidine kinase
M484_1078	COG0387	Pfam Sodium calcium exchanger
M484_1079	COG1702	phosphate starvation-inducible protein PhoH
M484_1082	COG3658	cytochrome
M484_1083	COG1215	transferase activity, transferring glycosyl groups
M484_1084	COG1649	PFAM Uncharacterised BCR, COG1649
M484_1084	COG0726	polysaccharide deacetylase
M484_1085	COG0457	Tetratricopeptide repeat
M484_1086	COG0006	proline dipeptidase activity
M484_109	COG3328	transposase activity
M484_1090	COG1136	(ABC) transporter
M484_1090	COG0577	efflux transmembrane transporter activity
M484_1092	COG1136	(ABC) transporter
M484_1092	COG0577	efflux transmembrane transporter activity
M484_1095	COG0672	)-iron permease
M484_1098	COG2066	Belongs to the glutaminase family
M484_1099	COG1349	DNA-binding transcription factor activity
M484_1101	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M484_1102	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M484_1110	COG2030	dehydratase
M484_1111	COG0427	acetyl-CoA hydrolase
M484_1114	COG2205	protein histidine kinase activity
M484_1114	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M484_1117	COG3188	usher protein
M484_1119	COG3121	Chaperone
M484_112	COG0351	phosphomethylpyrimidine kinase
M484_1120	COG3328	transposase activity
M484_1123	COG0582	viral genome integration into host DNA
M484_1124	COG1169	isochorismate synthase
M484_1125	COG2814	Major facilitator Superfamily
M484_1126	COG1132	(ABC) transporter
M484_1129	COG3433	isochorismatase activity
M484_1129	COG2226	methyltransferase
M484_1129	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M484_1133	COG1021	2,3-dihydroxybenzoate-AMP ligase
M484_1134	COG4771	TonB-dependent receptor
M484_1147	COG0395	ABC-type sugar transport system, permease component
M484_1148	COG1175	transmembrane transport
M484_1150	COG0673	inositol 2-dehydrogenase activity
M484_1157	COG3328	transposase activity
M484_1158	COG3328	transposase activity
M484_117	COG3422	double-strand break repair
M484_118	COG0745	RESPONSE REGULATOR receiver
M484_1181	COG2197	response regulator
M484_1183	COG3136	membrane protein required for alginate biosynthesis
M484_1187	COG1113	amino acid transport
M484_119	COG2205	protein histidine kinase activity
M484_1190	COG2837	iron assimilation
M484_1195	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M484_1195	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M484_1195	COG0506	proline dehydrogenase activity
M484_1202	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M484_1204	COG1191	sigma factor activity
M484_1210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M484_1211	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M484_1214	COG1677	Flagellar hook-basal body complex protein FliE
M484_1216	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M484_1218	COG1157	protein secretion by the type III secretion system
M484_1219	COG2882	bacterial-type flagellum organization
M484_1221	COG1580	Controls the rotational direction of flagella during chemotaxis
M484_1226	COG1987	bacterial-type flagellum assembly
M484_1230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M484_1231	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_1232	COG1129	ABC transporter
M484_1234	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_1235	COG3347	Dehydrogenase
M484_1235	COG1028	Short-chain dehydrogenase reductase Sdr
M484_1236	COG2390	Transcriptional regulator
M484_1238	COG1256	bacterial-type flagellum assembly
M484_1242	COG4786	Flagellar basal body rod
M484_1244	COG1749	Flagellar hook protein flgE
M484_1245	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M484_1246	COG1558	bacterial-type flagellum-dependent cell motility
M484_1247	COG1815	bacterial-type flagellum-dependent cell motility
M484_1249	COG2747	anti-sigma28 factor FlgM
M484_125	COG3842	ATPase activity
M484_1250	COG3418	PFAM FlgN family protein
M484_1252	COG1943	Transposase
M484_1258	COG2223	nitrite transmembrane transporter activity
M484_1263	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M484_1268	COG3122	Protein conserved in bacteria
M484_127	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M484_1272	COG0534	Mate efflux family protein
M484_1276	COG4948	Mandelate Racemase Muconate Lactonizing
M484_1278	COG1028	Short-chain dehydrogenase reductase Sdr
M484_1279	COG3011	Protein conserved in bacteria
M484_1280	COG2271	Major facilitator Superfamily
M484_1281	COG1470	cell adhesion involved in biofilm formation
M484_1281	COG1388	LysM domain
M484_1282	COG3328	transposase activity
M484_1283	COG3328	transposase activity
M484_1286	COG2925	Exonuclease
M484_1287	COG0531	amino acid
M484_1289	COG0371	Dehydrogenase
M484_129	COG1176	ABC-type spermidine putrescine transport system, permease component I
M484_1290	COG1129	ABC transporter
M484_1291	COG1129	ABC transporter
M484_1292	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_1294	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M484_1296	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M484_1298	COG0131	Imidazoleglycerol-phosphate dehydratase
M484_1298	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M484_1299	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M484_13	COG0539	negative regulation of cytoplasmic translation
M484_130	COG1177	transmembrane transport
M484_1302	COG0140	phosphoribosyl-ATP diphosphatase activity
M484_1302	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M484_1304	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M484_1305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M484_1308	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M484_1309	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M484_131	COG0443	Heat shock 70 kDa protein
M484_1310	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M484_1311	COG1120	ATPase activity
M484_1314	COG3486	L-lysine 6-monooxygenase (NADPH) activity
M484_1315	COG0076	glutamate decarboxylase activity
M484_1316	COG4114	ferric iron reductase
M484_1317	COG1253	flavin adenine dinucleotide binding
M484_1318	COG2982	Protein involved in outer membrane biogenesis
M484_132	COG2239	Acts as a magnesium transporter
M484_1321	COG0489	protein tyrosine kinase activity
M484_1323	COG1943	Transposase
M484_1327	COG2814	Major facilitator Superfamily
M484_1329	COG1346	cytolysis
M484_133	COG0248	Ppx GppA phosphatase
M484_1332	COG2949	membrane
M484_134	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M484_1341	COG0288	reversible hydration of carbon dioxide
M484_1358	COG3328	transposase activity
M484_1359	COG3328	transposase activity
M484_136	COG0581	inorganic phosphate transmembrane transporter activity
M484_1363	COG0840	transmembrane signaling receptor activity
M484_1365	COG0583	DNA-binding transcription factor activity
M484_1366	COG0583	DNA-binding transcription factor activity
M484_1367	COG2814	Major facilitator Superfamily
M484_1368	COG1609	Transcriptional regulator
M484_1369	COG0019	diaminopimelate decarboxylase activity
M484_1375	COG0667	Aldo Keto reductase
M484_1386	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M484_1388	COG1074	ATP-dependent DNA helicase activity
M484_1389	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M484_1393	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M484_1393	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M484_1394	COG0860	N-Acetylmuramoyl-L-alanine amidase
M484_1397	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M484_1398	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M484_1399	COG2166	iron-sulfur cluster assembly
M484_140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M484_1400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M484_1402	COG0583	DNA-binding transcription factor activity
M484_1403	COG2363	Small membrane protein
M484_1405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M484_1406	COG1611	Belongs to the LOG family
M484_1409	COG1943	Transposase
M484_141	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M484_1410	COG3098	single-species biofilm formation
M484_1411	COG0564	pseudouridine synthase activity
M484_1416	COG0024	Methionine aminopeptidase
M484_1422	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M484_1423	COG0575	Belongs to the CDS family
M484_1424	COG0750	zinc metalloprotease
M484_1426	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M484_1430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M484_1432	COG0587	DNA-directed DNA polymerase activity
M484_1434	COG0346	lactoylglutathione lyase activity
M484_1435	COG0037	tRNA processing
M484_1437	COG4568	rho-dependent transcription termination
M484_1439	COG4681	YaeQ
M484_1441	COG3015	lipoprotein NlpE involved in copper resistance
M484_1443	COG1720	tRNA m6t6A37 methyltransferase activity
M484_1445	COG1464	Belongs to the NlpA lipoprotein family
M484_1446	COG2011	ABC-type metal ion transport system permease component
M484_1448	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M484_145	COG1393	Belongs to the ArsC family
M484_1455	COG0656	L-ascorbic acid biosynthetic process
M484_1458	COG0741	lytic transglycosylase activity
M484_1458	COG1388	LysM domain
M484_146	COG4783	chaperone-mediated protein folding
M484_1460	COG2226	methyltransferase
M484_1462	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M484_1464	COG1953	Uracil, thiamine, allantoin
M484_1466	COG2113	Glycine betaine
M484_1467	COG4176	ABC-type proline glycine betaine transport system permease component
M484_1468	COG4175	Glycine betaine
M484_1469	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M484_147	COG0628	permease
M484_1477	COG1278	Cold shock
M484_1478	COG0747	negative chemotaxis
M484_1480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M484_1481	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M484_1482	COG1124	(ABC) transporter
M484_1489	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M484_1491	COG4413	Urea transporter
M484_1492	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M484_1494	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M484_1495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M484_1496	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M484_1497	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M484_1498	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M484_1499	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M484_150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M484_1500	COG1447	Phosphotransferase system cellobiose-specific component IIA
M484_1501	COG2169	Transcriptional regulator
M484_1501	COG1917	Cupin 2, conserved barrel domain protein
M484_1505	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M484_1506	COG0033	Phosphoglucomutase
M484_151	COG2716	regulation of RNA biosynthetic process
M484_1510	COG0745	RESPONSE REGULATOR receiver
M484_1511	COG2205	protein histidine kinase activity
M484_1512	COG2205	protein histidine kinase activity
M484_1517	COG3272	Protein of unknown function (DUF1722)
M484_1519	COG5212	phosphodiesterase
M484_1520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M484_1522	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M484_1523	COG1984	allophanate hydrolase subunit 2
M484_153	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M484_1534	COG0513	Belongs to the DEAD box helicase family
M484_1536	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M484_1538	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
M484_1539	COG3026	antisigma factor binding
M484_154	COG1943	Transposase
M484_1540	COG3086	response to oxidative stress
M484_1543	COG0681	Belongs to the peptidase S26 family
M484_1547	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M484_1549	COG1943	Transposase
M484_1550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M484_1554	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M484_1557	COG1067	ATP-dependent peptidase activity
M484_1559	COG1943	Transposase
M484_156	COG2321	neutral zinc metallopeptidase
M484_1560	COG1943	Transposase
M484_1561	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M484_1561	COG2885	chlorophyll binding
M484_1563	COG3070	regulator of competence-specific genes
M484_1564	COG1289	transmembrane transporter activity
M484_1565	COG3304	Inner membrane component domain
M484_1566	COG0210	DNA helicase
M484_1568	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M484_1569	COG1832	CoA-binding protein
M484_1573	COG2920	part of a sulfur-relay system
M484_1580	COG1028	Short-chain dehydrogenase reductase Sdr
M484_1582	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M484_1583	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M484_1584	COG1028	Short-chain dehydrogenase reductase Sdr
M484_1585	COG3425	synthase
M484_1587	COG1024	Enoyl-CoA hydratase
M484_1588	COG1028	Short-chain dehydrogenase reductase Sdr
M484_1590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M484_1591	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M484_16	COG2333	competence protein COMEC
M484_16	COG0658	competence protein
M484_160	COG1876	peptidase activity
M484_1618	COG0488	(ABC) transporter
M484_162	COG1393	Belongs to the ArsC family
M484_1621	COG0303	'Molybdopterin
M484_1623	COG1136	(ABC) transporter
M484_1629	COG0583	DNA-binding transcription factor activity
M484_1630	COG0477	Major facilitator Superfamily
M484_1632	COG2311	Membrane
M484_1635	COG4211	Belongs to the binding-protein-dependent transport system permease family
M484_1638	COG1943	Transposase
M484_1639	COG3119	arylsulfatase activity
M484_164	COG1840	ABC-type Fe3 transport system, periplasmic component
M484_1640	COG1349	DNA-binding transcription factor activity
M484_1642	COG2222	sugar isomerase
M484_1643	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M484_1644	COG3715	PTS system
M484_1645	COG3716	PTS system mannose fructose sorbose family IID component
M484_1646	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M484_1648	COG1028	Short-chain dehydrogenase reductase Sdr
M484_165	COG1175	transmembrane transport
M484_1650	COG0641	radical SAM
M484_1651	COG3119	arylsulfatase activity
M484_1653	COG0191	fructose-bisphosphate aldolase activity
M484_1657	COG2271	Major facilitator Superfamily
M484_166	COG3842	ATPase activity
M484_1661	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M484_1661	COG1263	PTS System
M484_1662	COG1874	Beta-galactosidase
M484_1663	COG1874	Beta-galactosidase
M484_1664	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M484_1665	COG3833	ABC-type maltose transport systems, permease component
M484_1666	COG1175	transmembrane transport
M484_1667	COG2182	Extracellular solute-binding protein
M484_1669	COG1129	ABC transporter
M484_167	COG3119	arylsulfatase activity
M484_1670	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_1671	COG1879	ABC-type sugar transport system periplasmic component
M484_1673	COG0791	NLP P60 protein
M484_1674	COG1695	Transcriptional regulator
M484_168	COG0641	radical SAM
M484_169	COG1988	membrane-bound metal-dependent
M484_1691	COG2944	sequence-specific DNA binding
M484_1696	COG0582	viral genome integration into host DNA
M484_1700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M484_1701	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M484_1702	COG4974	Belongs to the 'phage' integrase family
M484_1703	COG0716	FMN binding
M484_1704	COG4452	Inner membrane protein CreD
M484_1705	COG2205	protein histidine kinase activity
M484_1706	COG0745	RESPONSE REGULATOR receiver
M484_1707	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M484_171	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M484_1710	COG1272	protein, Hemolysin III
M484_1712	COG5295	Hep Hag repeat protein
M484_1718	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M484_1719	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M484_1720	COG0006	proline dipeptidase activity
M484_1723	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M484_1724	COG1943	Transposase
M484_1725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M484_1726	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M484_173	COG2197	response regulator
M484_1731	COG0191	fructose-bisphosphate aldolase activity
M484_1734	COG1943	Transposase
M484_1735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M484_1736	COG0501	Belongs to the peptidase M48B family
M484_1738	COG1166	arginine decarboxylase activity
M484_174	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
M484_174	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M484_1742	COG2356	endonuclease I
M484_1743	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M484_1744	COG0189	ligase activity
M484_1747	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M484_1749	COG2805	Type II/IV secretion system protein
M484_175	COG3062	negative regulation of establishment of protein localization
M484_1750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M484_1751	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M484_1752	COG0762	integral membrane protein
M484_1754	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M484_1755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M484_1756	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M484_1756	COG3064	Membrane
M484_1756	COG1073	alpha beta
M484_1759	COG2066	Belongs to the glutaminase family
M484_1760	COG3171	Protein conserved in bacteria
M484_1762	COG1194	a g-specific adenine glycosylase
M484_1766	COG4774	siderophore transport
M484_1767	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_1768	COG1129	ABC transporter
M484_1769	COG1879	ABC-type sugar transport system periplasmic component
M484_177	COG3043	anaerobic respiration
M484_1770	COG1982	Orn Lys Arg decarboxylase major
M484_1774	COG1662	PFAM IS1 transposase
M484_178	COG3005	denitrification pathway
M484_1792	COG2771	luxR family
M484_1793	COG3916	Acyl-homoserine-lactone synthase
M484_1803	COG2211	Major facilitator Superfamily
M484_1804	COG2801	Transposase and inactivated derivatives
M484_1806	COG3133	Outer membrane lipoprotein
M484_1811	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M484_1812	COG1191	sigma factor activity
M484_1817	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M484_1822	COG3710	Transcriptional regulator
M484_1826	COG1256	bacterial-type flagellum assembly
M484_1828	COG1706	bacterial-type flagellum-dependent cell motility
M484_1829	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M484_1830	COG4786	Flagellar basal body rod
M484_1831	COG4787	bacterial-type flagellum-dependent cell motility
M484_1832	COG1749	Flagellar hook protein flgE
M484_1833	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M484_1834	COG1558	bacterial-type flagellum-dependent cell motility
M484_1835	COG1815	bacterial-type flagellum-dependent cell motility
M484_1836	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
M484_1845	COG2204	response regulator
M484_1849	COG1987	bacterial-type flagellum assembly
M484_1850	COG1684	flagellar biosynthetic protein fliR
M484_1851	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M484_1855	COG4592	Periplasmic binding protein
M484_186	COG3111	PFAM Bacterial OB fold (BOF) protein
M484_1860	COG1943	Transposase
M484_1863	COG4964	Belongs to the GSP D family
M484_1864	COG4964	Belongs to the GSP D family
M484_1874	COG0848	biopolymer transport protein
M484_1876	COG0811	peptide transport
M484_1877	COG0626	cystathionine gamma-synthase activity
M484_1878	COG0586	Pfam SNARE associated Golgi protein
M484_1879	COG2207	Transcriptional regulator
M484_1880	COG1979	alcohol dehydrogenase
M484_1881	COG0656	L-ascorbic acid biosynthetic process
M484_1884	COG2132	Multicopper oxidase
M484_1885	COG0204	Acyl-transferase
M484_1886	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M484_1887	COG2249	NAD(P)H dehydrogenase (quinone) activity
M484_1888	COG0583	DNA-binding transcription factor activity
M484_1889	COG0187	DNA topoisomerase II activity
M484_189	COG2837	iron assimilation
M484_1890	COG3150	esterase
M484_1891	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M484_1892	COG3151	Protein conserved in bacteria
M484_1893	COG0494	nUDIX hydrolase
M484_1894	COG1538	Outer membrane efflux protein
M484_1897	COG0754	glutathionylspermidine amidase activity
M484_1898	COG3384	dioxygenase
M484_19	COG5383	Protein conserved in bacteria
M484_190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M484_1902	COG0531	amino acid
M484_1905	COG3025	triphosphatase activity
M484_1906	COG4991	sh3 domain protein
M484_1909	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M484_1913	COG0358	DNA primase activity
M484_1914	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M484_192	COG4886	Leucine-rich repeat (LRR) protein
M484_1932	COG0251	oxidation-reduction process
M484_194	COG2731	YhcH YjgK YiaL family protein
M484_1940	COG1289	transmembrane transporter activity
M484_1944	COG0395	ABC-type sugar transport system, permease component
M484_1946	COG1653	transport
M484_1947	COG1609	Transcriptional regulator
M484_1948	COG3459	Glycosyltransferase 36 associated
M484_1949	COG3842	ATPase activity
M484_195	COG1737	Transcriptional regulator
M484_1953	COG3210	domain, Protein
M484_1955	COG3210	domain, Protein
M484_1957	COG3210	domain, Protein
M484_1958	COG2831	hemolysin activation secretion protein
M484_1959	COG4245	von Willebrand factor, type A
M484_1962	COG4245	von Willebrand factor, type A
M484_1965	COG3247	response to pH
M484_1966	COG1902	pentaerythritol trinitrate reductase activity
M484_1966	COG0446	pyridine nucleotide-disulphide oxidoreductase
M484_1969	COG1451	nucleotide metabolic process
M484_197	COG4150	thiosulfate binding
M484_1970	COG0673	inositol 2-dehydrogenase activity
M484_1973	COG1943	Transposase
M484_1975	COG2721	sulfolactate sulfo-lyase activity
M484_1976	COG0246	Mannitol dehydrogenase
M484_1978	COG2271	Major facilitator Superfamily
M484_1979	COG2271	Major facilitator Superfamily
M484_198	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M484_1982	COG0586	Pfam SNARE associated Golgi protein
M484_1985	COG4575	ribosome binding
M484_1986	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
M484_1988	COG2259	Doxx family
M484_1989	COG0435	Glutathione S-transferase
M484_199	COG4208	sulfate ABC transporter
M484_1990	COG0583	DNA-binding transcription factor activity
M484_1991	COG1741	Belongs to the pirin family
M484_1992	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M484_1996	COG2823	Periplasmic or secreted lipoprotein
M484_1998	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M484_1999	COG5002	protein histidine kinase activity
M484_1999	COG0784	Response regulator, receiver
M484_1999	COG2198	Histidine kinase
M484_2	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M484_20	COG1278	Cold shock
M484_200	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M484_2000	COG1242	4 iron, 4 sulfur cluster binding
M484_2001	COG0070	glutamate synthase
M484_2001	COG0067	glutamate synthase
M484_2001	COG0069	glutamate synthase activity
M484_2002	COG0493	'glutamate synthase
M484_2004	COG2969	positive regulation of protein catabolic process
M484_2005	COG0625	glutathione transferase activity
M484_2008	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M484_2009	COG3105	Protein conserved in bacteria
M484_2010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M484_2011	COG1943	Transposase
M484_2012	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M484_2014	COG5007	Belongs to the BolA IbaG family
M484_2015	COG3113	response to antibiotic
M484_2016	COG2854	intermembrane phospholipid transfer
M484_2017	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M484_2018	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M484_2019	COG1127	ABC transporter
M484_2020	COG0530	calcium, potassium:sodium antiporter activity
M484_2021	COG0517	IMP dehydrogenase activity
M484_2021	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M484_2022	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M484_2023	COG3117	lipopolysaccharide transmembrane transporter activity
M484_2024	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M484_2025	COG1137	ATPase activity
M484_2026	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M484_2028	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M484_203	COG0745	RESPONSE REGULATOR receiver
M484_2030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M484_2036	COG1263	PTS System
M484_2036	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M484_2037	COG0366	Alpha amylase catalytic
M484_2038	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M484_2039	COG3783	Cytochrome b(562)
M484_204	COG3850	Histidine kinase
M484_204	COG5002	protein histidine kinase activity
M484_2041	COG0312	modulator of DNA gyrase
M484_2043	COG2732	(Barnase) inhibitor
M484_2046	COG1012	belongs to the aldehyde dehydrogenase family
M484_2050	COG0583	DNA-binding transcription factor activity
M484_206	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M484_2060	COG0312	modulator of DNA gyrase
M484_2061	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M484_2062	COG3164	Protein of unknown function
M484_2063	COG1530	ribonuclease E activity
M484_2065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M484_2066	COG1792	Involved in formation and maintenance of cell shape
M484_2067	COG1077	Cell shape determining protein MreB Mrl
M484_2068	COG2199	diguanylate cyclase activity
M484_2068	COG2200	EAL domain
M484_2069	COG0604	alcohol dehydrogenase
M484_2070	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M484_2073	COG0511	ligase activity, forming carbon-carbon bonds
M484_2074	COG0439	Biotin carboxylase
M484_2076	COG3924	membrane
M484_2077	COG4145	pantothenate transmembrane transporter activity
M484_2079	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M484_208	COG0006	proline dipeptidase activity
M484_2080	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M484_2084	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M484_2086	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M484_2087	COG3133	Outer membrane lipoprotein
M484_2088	COG1278	Cold shock
M484_2089	COG1278	Cold shock
M484_2090	COG1943	Transposase
M484_2093	COG0625	glutathione transferase activity
M484_2095	COG1069	ribulokinase activity
M484_2097	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_2098	COG1129	ABC transporter
M484_21	COG2835	tetraacyldisaccharide 4'-kinase activity
M484_210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M484_2100	COG1560	Kdo2-lipid A biosynthetic process
M484_2102	COG0025	NhaP-type Na H and K H
M484_2103	COG2252	PERMEase
M484_2104	COG3077	Addiction module antitoxin, RelB DinJ family
M484_2106	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M484_2108	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M484_2109	COG0431	NADPH-dependent FMN reductase
M484_2111	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M484_2112	COG1869	D-ribose catabolic process
M484_2113	COG1917	Cupin 2, conserved barrel domain protein
M484_2113	COG2207	Transcriptional regulator
M484_2114	COG0673	inositol 2-dehydrogenase activity
M484_2117	COG3209	COG3209 Rhs family protein
M484_2119	COG3501	Rhs element vgr protein
M484_2125	COG3209	COG3209 Rhs family protein
M484_2128	COG3501	Rhs element vgr protein
M484_213	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M484_214	COG0745	RESPONSE REGULATOR receiver
M484_2144	COG2801	Transposase and inactivated derivatives
M484_215	COG2205	protein histidine kinase activity
M484_2155	COG1175	transmembrane transport
M484_2156	COG3833	ABC-type maltose transport systems, permease component
M484_2159	COG0527	aspartate kinase activity
M484_2164	COG1414	Transcriptional regulator
M484_2166	COG2224	Isocitrate lyase
M484_2167	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M484_2178	COG0542	response to heat
M484_218	COG2190	(PTS) system
M484_2180	COG0564	pseudouridine synthase activity
M484_2181	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M484_2182	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M484_2183	COG0077	Prephenate dehydratase
M484_2183	COG1605	Chorismate mutase
M484_2184	COG0287	Prephenate dehydrogenase
M484_2184	COG1605	Chorismate mutase
M484_2185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M484_2188	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M484_2189	COG3279	Response regulator of the LytR AlgR family
M484_2190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M484_2191	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M484_2192	COG3137	Salt-induced outer membrane protein
M484_2197	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M484_2198	COG4137	Cytochrome C assembly protein
M484_2199	COG4536	flavin adenine dinucleotide binding
M484_220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M484_2201	COG2918	glutathione biosynthetic process
M484_2202	COG1238	metal cluster binding
M484_2203	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M484_2206	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M484_2207	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M484_221	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M484_2214	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M484_2215	COG3958	Transketolase
M484_2216	COG3959	Transketolase, thiamine diphosphate binding domain
M484_2217	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_2218	COG1129	ABC transporter
M484_222	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M484_2222	COG3783	Cytochrome b(562)
M484_2223	COG3038	cytochrome b561
M484_2224	COG3381	protein complex oligomerization
M484_2225	COG3302	dmso reductase anchor subunit
M484_2226	COG0437	4 iron, 4 sulfur cluster binding
M484_2227	COG0243	molybdopterin cofactor binding
M484_2228	COG0235	Class ii aldolase
M484_2229	COG1349	DNA-binding transcription factor activity
M484_2231	COG1129	ABC transporter
M484_2232	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_2233	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_2234	COG3623	hexulose-6-phosphate isomerase
M484_2235	COG1070	Carbohydrate kinase
M484_2236	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M484_2236	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M484_2238	COG0024	Methionine aminopeptidase
M484_2240	COG4771	TonB-dependent receptor
M484_2242	COG1858	cytochrome C peroxidase
M484_2243	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M484_2247	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M484_225	COG3530	Putative quorum-sensing-regulated virulence factor
M484_2250	COG2376	Dihydroxyacetone kinase
M484_2251	COG1028	Short-chain dehydrogenase reductase Sdr
M484_2252	COG1063	alcohol dehydrogenase
M484_2253	COG0698	ribose 5-phosphate isomerase
M484_2254	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M484_2255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M484_2256	COG1388	LysM domain
M484_2256	COG4942	peptidase
M484_2261	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M484_2264	COG0529	Catalyzes the synthesis of activated sulfate
M484_2275	COG0720	synthase
M484_2276	COG0602	queuosine metabolic process
M484_228	COG1943	Transposase
M484_2280	COG3956	TIGRFAM MazG family protein
M484_2281	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M484_2282	COG2205	protein histidine kinase activity
M484_2282	COG3437	response regulator, receiver
M484_2282	COG3850	Histidine kinase
M484_2282	COG4999	Histidine kinase
M484_2283	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M484_2285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M484_2287	COG2860	membrane
M484_2291	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M484_2292	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M484_2293	COG1120	ATPase activity
M484_2294	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M484_2295	COG1643	Atp-dependent helicase
M484_2296	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M484_2298	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M484_2299	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M484_23	COG3173	Aminoglycoside phosphotransferase
M484_2300	COG0617	tRNA 3'-terminal CCA addition
M484_2301	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M484_2305	COG0726	polysaccharide deacetylase
M484_2307	COG0842	Transport permease protein
M484_2308	COG1131	(ABC) transporter
M484_2309	COG0288	reversible hydration of carbon dioxide
M484_2310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M484_2311	COG2132	Multicopper oxidase
M484_2315	COG0697	spore germination
M484_2317	COG1049	propionate catabolic process, 2-methylcitrate cycle
M484_2318	COG1943	Transposase
M484_2319	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M484_2320	COG0508	dehydrogenase complex catalyzes the overall conversion of
M484_2321	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M484_2322	COG2186	Transcriptional regulator
M484_2323	COG1113	amino acid transport
M484_2324	COG3725	Membrane protein required for beta-lactamase induction
M484_2325	COG3023	N-Acetylmuramoyl-L-alanine amidase
M484_2327	COG4969	Belongs to the N-Me-Phe pilin family
M484_2328	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M484_2329	COG1459	type II secretion system
M484_2331	COG0237	dephospho-CoA kinase activity
M484_2334	COG1943	Transposase
M484_2336	COG0494	nUDIX hydrolase
M484_2341	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M484_2342	COG0849	cell division
M484_2343	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M484_2347	COG0772	Belongs to the SEDS family
M484_235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M484_2350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M484_2351	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M484_2352	COG0768	penicillin binding
M484_2353	COG3116	cell division
M484_2357	COG1943	Transposase
M484_2358	COG1943	Transposase
M484_2359	COG1609	Transcriptional regulator
M484_2360	COG1943	Transposase
M484_2362	COG0028	Belongs to the TPP enzyme family
M484_2363	COG3328	transposase activity
M484_2364	COG1022	Amp-dependent synthetase and ligase
M484_2368	COG0473	3-isopropylmalate dehydrogenase activity
M484_2371	COG2814	Major facilitator Superfamily
M484_2374	COG4143	(ABC) transporter
M484_2375	COG1178	ABC-type Fe3 transport system permease component
M484_2377	COG0586	Pfam SNARE associated Golgi protein
M484_2378	COG0417	DNA replication proofreading
M484_238	COG0667	Aldo Keto reductase
M484_2382	COG3047	cAMP biosynthetic process
M484_2382	COG2885	chlorophyll binding
M484_2389	COG3501	Rhs element vgr protein
M484_2399	COG0564	pseudouridine synthase activity
M484_24	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M484_2400	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M484_2402	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M484_2403	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M484_2408	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M484_2410	COG2966	Psort location CytoplasmicMembrane, score
M484_2411	COG1280	lysine exporter protein (LysE YggA)
M484_2412	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M484_2413	COG0505	Belongs to the CarA family
M484_2416	COG1047	Peptidyl-prolyl cis-trans
M484_2419	COG0196	riboflavin kinase activity
M484_2421	COG0583	DNA-binding transcription factor activity
M484_2425	COG1584	GPR1 FUN34 yaaH family protein
M484_2428	COG0521	Mo-molybdopterin cofactor biosynthetic process
M484_243	COG0436	Aminotransferase
M484_2436	COG0745	RESPONSE REGULATOR receiver
M484_2437	COG3045	CreA protein
M484_244	COG3038	cytochrome b561
M484_2440	COG2207	Transcriptional regulator
M484_2440	COG3708	Transcriptional regulator
M484_2441	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
M484_2443	COG0741	lytic transglycosylase activity
M484_2446	COG2199	diguanylate cyclase activity
M484_2447	COG2885	chlorophyll binding
M484_2448	COG0488	(ABC) transporter
M484_2453	COG0560	Phosphoserine phosphatase
M484_2454	COG3726	membrane protein affecting hemolysin expression
M484_2458	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M484_2459	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M484_2460	COG0084	hydrolase, TatD family'
M484_2461	COG4667	esterase of the alpha-beta hydrolase superfamily
M484_2463	COG2823	Periplasmic or secreted lipoprotein
M484_2465	COG0456	acetyltransferase
M484_2466	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
M484_2470	COG3706	GGDEF domain
M484_2473	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M484_2474	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M484_2477	COG0859	PFAM glycosyl transferase family 9
M484_2479	COG2390	Transcriptional regulator
M484_2487	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M484_2487	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M484_2487	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M484_2488	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M484_2489	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M484_2490	COG2207	Transcriptional regulator
M484_2491	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M484_2493	COG4269	membrane
M484_25	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
M484_250	COG3381	protein complex oligomerization
M484_2503	COG2963	transposase activity
M484_2505	COG1401	restriction endodeoxyribonuclease activity
M484_251	COG3302	dmso reductase anchor subunit
M484_2510	COG0582	viral genome integration into host DNA
M484_2512	COG0795	lipopolysaccharide-transporting ATPase activity
M484_2513	COG0795	lipopolysaccharide-transporting ATPase activity
M484_2515	COG2927	DNA polymerase III (CHI subunit)
M484_2516	COG0525	valine-tRNA ligase activity
M484_2518	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
M484_2519	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M484_252	COG0437	4 iron, 4 sulfur cluster binding
M484_2520	COG2731	YhcH YjgK YiaL family protein
M484_2523	COG0601	transmembrane transport
M484_2524	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M484_2525	COG0444	Belongs to the ABC transporter superfamily
M484_2526	COG4608	Belongs to the ABC transporter superfamily
M484_253	COG0243	molybdopterin cofactor binding
M484_2530	COG2188	Transcriptional regulator
M484_2531	COG3624	Phosphonate C-P lyase system protein PhnG
M484_2532	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
M484_2533	COG3626	phosphonate metabolism
M484_2534	COG3627	carbon phosphorus lyase activity
M484_2535	COG4107	phosphonate C-P lyase system protein PhnK
M484_2536	COG4778	phosphonate C-P lyase system protein PhnL
M484_2537	COG3454	Phosphonate metabolism
M484_2538	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
M484_2539	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M484_2540	COG0702	epimerase
M484_2543	COG3842	ATPase activity
M484_2544	COG0395	ABC-type sugar transport system, permease component
M484_2546	COG1653	transport
M484_2550	COG3153	acetyltransferase
M484_2555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M484_2558	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M484_2561	COG0513	Belongs to the DEAD box helicase family
M484_2565	COG2801	Transposase and inactivated derivatives
M484_2568	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M484_2569	COG0058	SHG alpha-glucan phosphorylase activity
M484_2571	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M484_2574	COG3275	phosphorelay sensor kinase activity
M484_2580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M484_2581	COG2095	MarC family integral membrane protein
M484_2585	COG3265	gluconokinase activity
M484_2586	COG2610	gluconate transmembrane transporter activity
M484_2587	COG1609	Transcriptional regulator
M484_2588	COG1609	Transcriptional regulator
M484_2589	COG1741	Belongs to the pirin family
M484_2591	COG0745	RESPONSE REGULATOR receiver
M484_2593	COG0191	fructose-bisphosphate aldolase activity
M484_2595	COG1879	ABC-type sugar transport system periplasmic component
M484_2596	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_2598	COG0840	transmembrane signaling receptor activity
M484_2598	COG2972	Histidine kinase
M484_26	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M484_260	COG2951	lytic endotransglycosylase activity
M484_2600	COG2081	HI0933 family
M484_2601	COG0306	phosphate transporter
M484_2602	COG1943	Transposase
M484_2604	COG0589	response to stress
M484_2608	COG0339	signal peptide processing
M484_2609	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M484_2610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M484_2611	COG3835	regulator
M484_2612	COG2610	gluconate transmembrane transporter activity
M484_2613	COG1929	Belongs to the glycerate kinase type-1 family
M484_2618	COG1295	ribonuclease BN
M484_2619	COG2134	cdp-diacylglycerol pyrophosphatase
M484_2620	COG2982	Protein involved in outer membrane biogenesis
M484_2621	COG2200	EAL domain
M484_2622	COG1942	4-Oxalocrotonate Tautomerase
M484_2623	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M484_2624	COG0612	Peptidase, M16
M484_2629	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M484_2630	COG2200	EAL domain
M484_2630	COG2199	diguanylate cyclase activity
M484_2631	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M484_2632	COG4608	Belongs to the ABC transporter superfamily
M484_2633	COG0444	Belongs to the ABC transporter superfamily
M484_2634	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M484_2635	COG0601	transmembrane transport
M484_2636	COG0747	negative chemotaxis
M484_2638	COG2831	hemolysin activation secretion protein
M484_2642	COG2271	Major facilitator Superfamily
M484_2643	COG3851	Histidine kinase
M484_2644	COG2197	response regulator
M484_2645	COG2194	sulfuric ester hydrolase activity
M484_2648	COG3650	response to hydrogen peroxide
M484_2649	COG1960	acyl-CoA dehydrogenase activity
M484_2650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M484_2651	COG0557	exoribonuclease II activity
M484_2654	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M484_2655	COG0330	HflC and HflK could
M484_2656	COG0330	HflC and HflK could
M484_2657	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M484_2661	COG0860	N-Acetylmuramoyl-L-alanine amidase
M484_2662	COG0802	atpase or kinase
M484_2663	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M484_2663	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M484_2664	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M484_2667	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M484_2670	COG3264	Mechanosensitive ion channel
M484_2670	COG1511	domain protein
M484_2672	COG1053	succinate dehydrogenase
M484_2673	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M484_2675	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M484_2676	COG2076	Multidrug Resistance protein
M484_2684	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M484_2687	COG3383	formate dehydrogenase (NAD+) activity
M484_2688	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M484_2689	COG0493	'glutamate synthase
M484_2689	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M484_2690	COG1309	transcriptional regulator
M484_2705	COG1454	alcohol dehydrogenase
M484_2707	COG0629	single-stranded DNA binding
M484_2708	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M484_2709	COG2315	Protein conserved in bacteria
M484_2710	COG1448	Aminotransferase
M484_2711	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M484_2712	COG0305	Participates in initiation and elongation during chromosome replication
M484_2715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M484_2716	COG0735	belongs to the Fur family
M484_2718	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M484_272	COG3121	Chaperone
M484_2727	COG3121	Chaperone
M484_273	COG3188	usher protein
M484_2739	COG1358	cellular component organization or biogenesis
M484_274	COG3328	transposase activity
M484_2744	COG3721	Heme iron utilization protein
M484_2745	COG0702	epimerase
M484_2747	COG4771	TonB-dependent receptor
M484_2748	COG3720	iron ion transport
M484_2749	COG4558	Periplasmic binding protein
M484_275	COG3188	usher protein
M484_2750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M484_2752	COG0626	cystathionine gamma-synthase activity
M484_2753	COG0814	amino acid
M484_2754	COG0583	DNA-binding transcription factor activity
M484_2755	COG0425	Belongs to the sulfur carrier protein TusA family
M484_2756	COG2391	methyltransferase activity
M484_2778	COG1301	dicarboxylic acid transport
M484_2780	COG3162	membrane
M484_2786	COG2801	Transposase and inactivated derivatives
M484_2793	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M484_2796	COG0551	DNA topoisomerase type I activity
M484_2798	COG0758	DNA mediated transformation
M484_28	COG1943	Transposase
M484_2802	COG0569	domain protein
M484_2804	COG3036	rescue of stalled ribosome
M484_2805	COG0789	Transcriptional regulator
M484_2808	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M484_2811	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M484_2812	COG0201	protein transport
M484_2814	COG1841	ribosomal large subunit assembly
M484_2822	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M484_2823	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M484_2825	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M484_2826	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M484_2828	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M484_2833	COG0051	transcription antitermination factor activity, RNA binding
M484_2836	COG1943	Transposase
M484_2839	COG0049	tRNA binding
M484_2844	COG2964	Protein conserved in bacteria
M484_2845	COG0545	Peptidyl-prolyl cis-trans isomerase
M484_2847	COG1047	Peptidyl-prolyl cis-trans
M484_2848	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M484_2851	COG0488	(ABC) transporter
M484_2852	COG1216	Glycosyl transferase, family 2
M484_2855	COG2175	clavaminate synthase activity
M484_2856	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M484_2858	COG4521	taurine ABC transporter
M484_2860	COG0429	hydrolase of the alpha beta-hydrolase fold
M484_2862	COG3954	Phosphoribulokinase
M484_2864	COG1765	OsmC-like protein
M484_2866	COG1289	transmembrane transporter activity
M484_2869	COG0433	COG0433 Predicted ATPase
M484_2870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M484_2871	COG1486	melibiose metabolic process
M484_2875	COG0402	S-adenosylhomocysteine deaminase activity
M484_2876	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M484_2877	COG2146	nitrite reductase [NAD(P)H] activity
M484_288	COG3501	Rhs element vgr protein
M484_2880	COG0180	Tryptophanyl-tRNA synthetase
M484_2881	COG0546	phosphoglycolate phosphatase activity
M484_2882	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M484_2887	COG4796	Type ii and iii secretion system protein
M484_2892	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M484_2893	COG0494	nUDIX hydrolase
M484_2896	COG1011	Hydrolase
M484_2897	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M484_29	COG2989	Protein conserved in bacteria
M484_2901	COG0745	RESPONSE REGULATOR receiver
M484_2902	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M484_2903	COG2183	response to ionizing radiation
M484_2904	COG1918	ferrous iron import across plasma membrane
M484_2911	COG1640	4-alpha-glucanotransferase
M484_2912	COG0058	SHG alpha-glucan phosphorylase activity
M484_2916	COG1349	DNA-binding transcription factor activity
M484_2918	COG2801	Transposase and inactivated derivatives
M484_2923	COG3328	transposase activity
M484_2925	COG3276	selenocysteine insertion sequence binding
M484_2928	COG2864	formate dehydrogenase
M484_2929	COG0437	4 iron, 4 sulfur cluster binding
M484_2930	COG3383	formate dehydrogenase (NAD+) activity
M484_2930	COG0243	molybdopterin cofactor binding
M484_2931	COG3383	formate dehydrogenase (NAD+) activity
M484_2931	COG0243	molybdopterin cofactor binding
M484_2933	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M484_294	COG2824	Alkylphosphonate utilization operon protein PhnA
M484_2940	COG3722	fumarate hydratase activity
M484_2942	COG2213	PTS system mannitol-specific
M484_2942	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M484_2947	COG2818	Glycosylase
M484_2949	COG2885	chlorophyll binding
M484_2952	COG0366	Alpha amylase catalytic
M484_2954	COG3977	Valine--pyruvate aminotransferase
M484_2958	COG5645	(Lipo)protein
M484_2959	COG0823	Involved in the tonB-independent uptake of proteins
M484_296	COG1704	LemA family
M484_2960	COG0823	Involved in the tonB-independent uptake of proteins
M484_2961	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M484_2962	COG2423	ornithine cyclodeaminase activity
M484_2964	COG2801	Transposase and inactivated derivatives
M484_2965	COG0561	phosphatase activity
M484_2966	COG0187	DNA topoisomerase II activity
M484_2967	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M484_2968	COG0592	DNA-directed DNA polymerase activity
M484_2971	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M484_2974	COG0706	membrane insertase activity
M484_2979	COG2252	PERMEase
M484_2980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M484_2981	COG0765	amino acid transport
M484_2982	COG0765	amino acid transport
M484_2983	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M484_2985	COG0704	Plays a role in the regulation of phosphate uptake
M484_2987	COG0581	inorganic phosphate transmembrane transporter activity
M484_2988	COG0573	inorganic phosphate transmembrane transporter activity
M484_2989	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M484_2991	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M484_30	COG3108	Peptidase M15
M484_300	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M484_3001	COG3312	ion transport
M484_3004	COG0716	FMN binding
M484_3005	COG1522	sequence-specific DNA binding
M484_301	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M484_3011	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M484_3012	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M484_3013	COG0477	Major facilitator Superfamily
M484_3015	COG2186	Transcriptional regulator
M484_302	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M484_3021	COG3328	transposase activity
M484_3022	COG1763	Mo-molybdopterin cofactor biosynthetic process
M484_3024	COG3084	Protein conserved in bacteria
M484_3025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M484_3026	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M484_3027	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M484_3027	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M484_3030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M484_3032	COG3852	Histidine kinase
M484_3033	COG0174	glutamine synthetase
M484_3035	COG1011	Hydrolase
M484_3036	COG1295	ribonuclease BN
M484_304	COG1138	Cytochrome C-type biogenesis protein
M484_3040	COG0456	acetyltransferase
M484_3041	COG2982	Protein involved in outer membrane biogenesis
M484_3042	COG2233	PERMEase
M484_3043	COG0786	glutamate:sodium symporter activity
M484_3044	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M484_3045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M484_3046	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M484_3049	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M484_305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M484_3050	COG2860	membrane
M484_3051	COG1561	YicC-like family, N-terminal region
M484_3056	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M484_3059	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M484_306	COG3088	subunit of a heme lyase
M484_306	COG4235	cytochrome complex assembly
M484_3063	COG1519	Transferase
M484_3064	COG0859	PFAM glycosyl transferase family 9
M484_3065	COG0859	PFAM glycosyl transferase family 9
M484_3067	COG0156	8-amino-7-oxononanoate synthase activity
M484_3069	COG2861	carbohydrate metabolic process
M484_307	COG3088	subunit of a heme lyase
M484_307	COG4235	cytochrome complex assembly
M484_3070	COG2861	carbohydrate metabolic process
M484_3071	COG4942	peptidase
M484_3073	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M484_3074	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M484_3077	COG1045	serine acetyltransferase
M484_3078	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M484_3079	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M484_3079	COG2169	Transcriptional regulator
M484_3080	COG2205	protein histidine kinase activity
M484_3081	COG0745	RESPONSE REGULATOR receiver
M484_3082	COG3678	ATP-independent chaperone mediated protein folding
M484_3087	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M484_3089	COG0471	metal ion transport
M484_3090	COG0471	metal ion transport
M484_3091	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M484_3092	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M484_3093	COG0583	DNA-binding transcription factor activity
M484_3096	COG3152	Membrane
M484_3098	COG1494	fructose-1,6-bisphosphatase
M484_3099	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M484_31	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M484_310	COG3691	Protein conserved in bacteria
M484_3100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M484_3102	COG1943	Transposase
M484_3108	COG1575	Belongs to the MenA family. Type 1 subfamily
M484_3111	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M484_3112	COG1609	Transcriptional regulator
M484_3114	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M484_3116	COG4682	membrane
M484_3118	COG0626	cystathionine gamma-synthase activity
M484_3119	COG0527	aspartate kinase activity
M484_3119	COG0460	homoserine dehydrogenase
M484_3121	COG2801	Transposase and inactivated derivatives
M484_3123	COG3274	enterobacterial common antigen metabolic process
M484_3125	COG3188	usher protein
M484_3126	COG3188	usher protein
M484_3127	COG3121	Chaperone
M484_3129	COG1070	Carbohydrate kinase
M484_313	COG2062	phosphohistidine phosphatase, SixA
M484_3131	COG4213	ABC transporter substrate-binding protein
M484_3133	COG4214	carbohydrate transport
M484_3134	COG2207	Transcriptional regulator
M484_3134	COG1609	Transcriptional regulator
M484_3136	COG0582	viral genome integration into host DNA
M484_3143	COG4604	ABC transporter, ATP-binding protein
M484_3145	COG4605	iron ion homeostasis
M484_3147	COG4607	ABC-type enterochelin transport system periplasmic component
M484_315	COG2890	protein-(glutamine-N5) methyltransferase activity
M484_3150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M484_3153	COG2986	histidine ammonia-lyase
M484_3164	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M484_3165	COG0250	Participates in transcription elongation, termination and antitermination
M484_3173	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M484_3178	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M484_318	COG0730	response to heat
M484_3180	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M484_3185	COG1515	deoxyribonuclease V activity
M484_3186	COG3068	Protein conserved in bacteria
M484_3189	COG0151	Belongs to the GarS family
M484_319	COG3101	peptidyl-lysine hydroxylation
M484_3199	COG1879	ABC-type sugar transport system periplasmic component
M484_32	COG1448	Aminotransferase
M484_3200	COG1129	ABC transporter
M484_3201	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_3203	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_3204	COG3085	chromosome segregation
M484_3207	COG3978	acetolactate synthase activity
M484_3208	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M484_3216	COG0583	DNA-binding transcription factor activity
M484_322	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M484_3223	COG3121	Chaperone
M484_3226	COG3121	Chaperone
M484_3229	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M484_323	COG1794	racemase activity, acting on amino acids and derivatives
M484_3233	COG3118	belongs to the thioredoxin family
M484_3234	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M484_3235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M484_3236	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M484_3237	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M484_3238	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M484_3239	COG1088	dTDP-glucose 4,6-dehydratase activity
M484_3240	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M484_3241	COG0456	acetyltransferase
M484_3242	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M484_3243	COG2244	polysaccharide biosynthetic process
M484_3247	COG1113	amino acid transport
M484_3253	COG1943	Transposase
M484_3254	COG3071	HemY protein
M484_3255	COG2959	enzyme of heme biosynthesis
M484_3256	COG1587	Uroporphyrinogen-III synthase
M484_3258	COG3072	Adenylate cyclase
M484_326	COG0697	spore germination
M484_3260	COG5567	small periplasmic lipoprotein
M484_3262	COG3159	Protein conserved in bacteria
M484_3263	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M484_3264	COG1011	Hydrolase
M484_3265	COG0210	DNA helicase
M484_3267	COG5441	Belongs to the UPF0261 family
M484_3268	COG5564	TIM-barrel signal transduction protein
M484_3269	COG0598	Magnesium transport protein CorA
M484_3271	COG2050	protein possibly involved in aromatic compounds catabolism
M484_3272	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
M484_3273	COG0514	ATP-dependent DNA helicase (RecQ)
M484_3274	COG1280	lysine exporter protein (LysE YggA)
M484_3275	COG1280	lysine exporter protein (LysE YggA)
M484_3276	COG2267	carboxylic ester hydrolase activity
M484_3277	COG0561	phosphatase activity
M484_3279	COG0584	glycerophosphoryl diester phosphodiesterase
M484_3280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M484_3282	COG0247	lactate metabolic process
M484_3284	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M484_3287	COG3714	YhhN family
M484_329	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M484_3290	COG3776	membrane
M484_3291	COG0742	ribosomal rna small subunit methyltransferase
M484_3292	COG0552	protein localization to endoplasmic reticulum
M484_3292	COG0552	protein localization to endoplasmic reticulum
M484_3293	COG2884	Cell division ATP-binding protein ftsE
M484_3294	COG2177	Part of the ABC transporter FtsEX involved in
M484_3296	COG1943	Transposase
M484_3298	COG0683	leucine binding
M484_3299	COG0559	Belongs to the binding-protein-dependent transport system permease family
M484_3300	COG4177	L-phenylalanine transmembrane transporter activity
M484_3301	COG0411	ABC transporter
M484_3302	COG0410	ABC transporter
M484_331	COG0586	Pfam SNARE associated Golgi protein
M484_3314	COG0584	glycerophosphoryl diester phosphodiesterase
M484_3315	COG0679	Auxin Efflux Carrier
M484_3316	COG0583	DNA-binding transcription factor activity
M484_3319	COG0412	Dienelactone hydrolase
M484_3320	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M484_3322	COG1966	Carbon starvation protein
M484_3323	COG0586	Pfam SNARE associated Golgi protein
M484_3324	COG1322	Protein conserved in bacteria
M484_3328	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M484_333	COG0285	dihydrofolate synthase activity
M484_3330	COG0805	protein transport
M484_3339	COG1739	Uncharacterized protein family UPF0029
M484_334	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M484_3340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M484_3341	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
M484_3347	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M484_335	COG1286	toxin biosynthetic process
M484_3355	COG1073	alpha beta
M484_3358	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M484_336	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M484_3360	COG1943	Transposase
M484_3362	COG3061	Opacity-associated protein A
M484_3363	COG0545	Peptidyl-prolyl cis-trans isomerase
M484_3365	COG0737	Belongs to the 5'-nucleotidase family
M484_3367	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M484_3369	COG1253	flavin adenine dinucleotide binding
M484_337	COG0163	prenyltransferase activity
M484_3371	COG0729	surface antigen
M484_3372	COG2911	Protein conserved in bacteria
M484_3373	COG2105	PFAM AIG2 family protein
M484_3374	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M484_3376	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M484_338	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M484_3380	COG3423	Transcriptional regulator
M484_3382	COG0142	geranyltranstransferase activity
M484_3385	COG0697	spore germination
M484_3387	COG0642	Histidine kinase
M484_3388	COG0745	RESPONSE REGULATOR receiver
M484_3389	COG2027	D-alanyl-D-alanine carboxypeptidase
M484_339	COG4215	(ABC) transporter
M484_3390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M484_3391	COG1534	Rna-binding protein
M484_3393	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M484_3394	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M484_3396	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M484_340	COG4160	amino acid transport
M484_3400	COG0195	Participates in both transcription termination and antitermination
M484_3405	COG2801	Transposase and inactivated derivatives
M484_3409	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M484_341	COG4598	ABC transporter
M484_3413	COG1629	transport
M484_3418	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M484_3419	COG0678	peroxiredoxin activity
M484_3419	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M484_342	COG1090	epimerase
M484_3433	COG5544	Lipoprotein
M484_3434	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M484_3435	COG1042	CoA-binding domain protein
M484_3435	COG0045	succinate-CoA ligase (ADP-forming) activity
M484_3435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M484_3437	COG3118	belongs to the thioredoxin family
M484_3438	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M484_3439	COG2814	Major facilitator Superfamily
M484_344	COG0622	Phosphoesterase
M484_3440	COG1566	PFAM secretion protein HlyD family protein
M484_3441	COG1846	Transcriptional regulator
M484_3443	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M484_3444	COG2814	Major facilitator Superfamily
M484_345	COG0622	Phosphoesterase
M484_3453	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M484_3456	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M484_3459	COG0436	Aminotransferase
M484_346	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M484_3467	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
M484_3469	COG1943	Transposase
M484_347	COG3037	sugar-specific permease SgaT UlaA
M484_3470	COG1960	acyl-CoA dehydrogenase activity
M484_3472	COG3034	peptidoglycan biosynthetic process
M484_3473	COG0121	glutamine amidotransferase
M484_3474	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M484_3475	COG1805	sodium ion transport
M484_3476	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M484_3480	COG1477	protein flavinylation
M484_3484	COG2195	Cleaves the N-terminal amino acid of tripeptides
M484_3495	COG2226	methyltransferase
M484_350	COG1609	Transcriptional regulator
M484_3500	COG1940	carbohydrate kinase activity
M484_3501	COG0419	ATPase involved in DNA repair
M484_3502	COG0420	3'-5' exonuclease activity
M484_3503	COG0745	RESPONSE REGULATOR receiver
M484_3504	COG1943	Transposase
M484_3505	COG0745	RESPONSE REGULATOR receiver
M484_3506	COG5002	protein histidine kinase activity
M484_3508	COG1114	Component of the transport system for branched-chain amino acids
M484_351	COG0280	phosphate acetyltransferase
M484_351	COG0857	belongs to the CobB CobQ family
M484_3510	COG0366	Alpha amylase catalytic
M484_3514	COG0450	alkyl hydroperoxide reductase
M484_3515	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M484_3516	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M484_3518	COG1862	Preprotein translocase
M484_3519	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M484_3520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M484_3521	COG1943	Transposase
M484_3525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M484_3525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M484_3528	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M484_3529	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M484_3530	COG1943	Transposase
M484_3532	COG0142	geranyltranstransferase activity
M484_3535	COG0693	protein deglycase activity
M484_3536	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M484_3538	COG2814	Major facilitator Superfamily
M484_3540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M484_3541	COG1845	cytochrome c oxidase, subunit III
M484_3542	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M484_3543	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M484_3545	COG2223	nitrite transmembrane transporter activity
M484_3546	COG3056	Lipoprotein
M484_3547	COG0271	Belongs to the BolA IbaG family
M484_355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M484_3552	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M484_3553	COG0776	regulation of translation
M484_3555	COG1943	Transposase
M484_3556	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M484_3557	COG1555	photosystem II stabilization
M484_3558	COG0824	Thioesterase
M484_356	COG0490	domain, Protein
M484_356	COG0471	metal ion transport
M484_3560	COG4533	DNA binding
M484_3563	COG1522	sequence-specific DNA binding
M484_3564	COG1132	(ABC) transporter
M484_3565	COG1132	(ABC) transporter
M484_3566	COG0347	Belongs to the P(II) protein family
M484_3567	COG0004	ammonium transporteR
M484_3568	COG1946	Acyl-CoA thioesterase
M484_3569	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M484_3570	COG3695	enzyme binding
M484_3574	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M484_3576	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M484_3577	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M484_3578	COG1309	transcriptional regulator
M484_3579	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M484_358	COG0436	Aminotransferase
M484_3580	COG1196	nuclear chromosome segregation
M484_3580	COG3264	Mechanosensitive ion channel
M484_3582	COG2832	Protein of unknown function (DUF454)
M484_3584	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M484_359	COG0583	DNA-binding transcription factor activity
M484_3590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M484_3590	COG0543	2 iron, 2 sulfur cluster binding
M484_3594	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M484_36	COG0308	aminopeptidase N
M484_3602	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
M484_3603	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
M484_3604	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M484_3608	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M484_3609	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M484_361	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M484_3610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M484_3610	COG4651	solute:proton antiporter activity
M484_3611	COG2223	nitrite transmembrane transporter activity
M484_3612	COG2223	nitrite transmembrane transporter activity
M484_3613	COG0737	Belongs to the 5'-nucleotidase family
M484_3614	COG0737	Belongs to the 5'-nucleotidase family
M484_3615	COG0737	Belongs to the 5'-nucleotidase family
M484_3618	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M484_3619	COG3735	TraB family
M484_3620	COG2217	Heavy metal translocating P-type atpase
M484_3621	COG0789	Transcriptional regulator
M484_3622	COG1585	Membrane protein implicated in regulation of membrane protease activity
M484_3623	COG0330	HflC and HflK could
M484_3624	COG3118	belongs to the thioredoxin family
M484_3625	COG0300	oxidoreductase activity
M484_3626	COG2755	lipolytic protein G-D-S-L family
M484_3627	COG4181	ATPase activity
M484_3628	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M484_3629	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M484_363	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M484_3630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M484_3632	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M484_3635	COG1943	Transposase
M484_3636	COG2501	S4 domain
M484_3643	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M484_3644	COG4589	Belongs to the CDS family
M484_3646	COG2267	carboxylic ester hydrolase activity
M484_3647	COG2453	phosphatase
M484_3647	COG0671	phosphoesterase, PA-phosphatase related
M484_365	COG1034	ATP synthesis coupled electron transport
M484_3653	COG0667	Aldo Keto reductase
M484_3654	COG0656	L-ascorbic acid biosynthetic process
M484_3659	COG3328	transposase activity
M484_3660	COG3328	transposase activity
M484_3661	COG2850	peptidyl-arginine hydroxylation
M484_3670	COG3423	Transcriptional regulator
M484_3671	COG4953	penicillin-binding protein 1C
M484_3672	COG2373	Large extracellular alpha-helical protein
M484_3678	COG3962	Belongs to the TPP enzyme family
M484_3679	COG0673	inositol 2-dehydrogenase activity
M484_368	COG0839	Belongs to the complex I subunit 6 family
M484_3680	COG0673	inositol 2-dehydrogenase activity
M484_3681	COG1879	ABC-type sugar transport system periplasmic component
M484_3682	COG1129	ABC transporter
M484_3683	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_3684	COG0673	inositol 2-dehydrogenase activity
M484_3685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M484_3687	COG3718	enzyme involved in inositol metabolism
M484_3689	COG5265	(ABC) transporter
M484_3694	COG2197	response regulator
M484_3695	COG1278	Cold shock
M484_3696	COG1278	Cold shock
M484_3697	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M484_3698	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M484_370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M484_3702	COG1686	Belongs to the peptidase S11 family
M484_3703	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M484_3704	COG0772	Belongs to the SEDS family
M484_3705	COG0768	penicillin binding
M484_3707	COG0799	negative regulation of ribosome biogenesis
M484_3709	COG1466	dna polymerase III delta subunit
M484_371	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M484_3712	COG2888	peptidyl-tyrosine sulfation
M484_3713	COG1126	abc transporter atp-binding protein
M484_3714	COG0765	amino acid transport
M484_3715	COG0765	amino acid transport
M484_3717	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M484_3718	COG4535	Mg2 and Co2 transporter CorC
M484_3720	COG1702	phosphate starvation-inducible protein PhoH
M484_3722	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M484_3728	COG0367	asparagine synthase
M484_3729	COG0647	UMP catabolic process
M484_3730	COG1940	carbohydrate kinase activity
M484_3730	COG1846	Transcriptional regulator
M484_3731	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M484_3733	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M484_3733	COG2190	(PTS) system
M484_3733	COG1263	PTS System
M484_3738	COG0735	belongs to the Fur family
M484_374	COG2731	YhcH YjgK YiaL family protein
M484_3742	COG0596	Alpha beta hydrolase
M484_3744	COG2963	transposase activity
M484_3745	COG0582	viral genome integration into host DNA
M484_3749	COG3657	addiction module killer protein
M484_375	COG3265	gluconokinase activity
M484_3759	COG0582	viral genome integration into host DNA
M484_376	COG1028	Short-chain dehydrogenase reductase Sdr
M484_3760	COG1943	Transposase
M484_3762	COG2867	negative regulation of translational initiation
M484_3764	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M484_3765	COG0497	DNA recombination
M484_3766	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M484_3769	COG2009	succinate dehydrogenase
M484_3770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M484_3771	COG1053	succinate dehydrogenase
M484_3773	COG0567	Dehydrogenase, E1 component
M484_3774	COG0508	dehydrogenase complex catalyzes the overall conversion of
M484_3776	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M484_3777	COG1943	Transposase
M484_3778	COG1271	oxidase subunit
M484_3779	COG1294	oxidase, subunit
M484_378	COG1609	Transcriptional regulator
M484_3780	COG4890	Cyd operon protein YbgT
M484_3781	COG3790	cyd operon protein YbgE
M484_3782	COG0824	Thioesterase
M484_3783	COG0811	peptide transport
M484_3784	COG0848	biopolymer transport protein
M484_3785	COG3064	Membrane
M484_3785	COG3064	Membrane
M484_3787	COG2885	chlorophyll binding
M484_3788	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M484_379	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M484_3794	COG1230	cation diffusion facilitator family transporter
M484_3795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M484_3796	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M484_3799	COG2017	converts alpha-aldose to the beta-anomer
M484_3802	COG1085	galactose-1-phosphate uridylyltransferase
M484_3803	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M484_3807	COG1119	ATPase activity
M484_3808	COG2005	Transcriptional regulator
M484_3808	COG3585	molybdate ion transport
M484_3810	COG0725	ABC transporter, periplasmic molybdate-binding protein
M484_3811	COG4149	molybdate abc transporter
M484_3813	COG0561	phosphatase activity
M484_3818	COG2226	methyltransferase
M484_3819	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M484_382	COG0129	dihydroxy-acid dehydratase activity
M484_3821	COG0556	nucleotide-excision repair
M484_3822	COG4628	conserved protein (DUF2132)
M484_3823	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M484_3825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M484_3827	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M484_3828	COG0314	molybdopterin synthase activity
M484_3829	COG0670	Belongs to the BI1 family
M484_3830	COG1943	Transposase
M484_3834	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M484_3835	COG0583	DNA-binding transcription factor activity
M484_3837	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M484_3838	COG2211	Major facilitator Superfamily
M484_384	COG4575	ribosome binding
M484_3840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M484_3842	COG1686	Belongs to the peptidase S11 family
M484_3843	COG0277	FAD linked oxidase domain protein
M484_3845	COG1403	HNH endonuclease
M484_3847	COG2261	transglycosylase associated protein
M484_3849	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
M484_3852	COG4807	Protein conserved in bacteria
M484_3856	COG1122	ATPase activity
M484_3857	COG0410	ABC transporter
M484_386	COG1169	isochorismate synthase
M484_3860	COG2897	thiosulfate sulfurtransferase activity
M484_3861	COG1732	Glycine betaine
M484_3862	COG1174	glycine betaine transport
M484_3863	COG1125	glycine betaine transport
M484_3864	COG1174	glycine betaine transport
M484_3865	COG0531	amino acid
M484_3866	COG1982	Orn Lys Arg decarboxylase major
M484_3867	COG3328	transposase activity
M484_3868	COG1982	Orn Lys Arg decarboxylase major
M484_3870	COG0697	spore germination
M484_3875	COG0814	amino acid
M484_3878	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M484_3883	COG2205	protein histidine kinase activity
M484_3883	COG0784	Response regulator, receiver
M484_3885	COG2198	Histidine kinase
M484_3885	COG0642	Histidine kinase
M484_3886	COG2198	Histidine kinase
M484_3886	COG0642	Histidine kinase
M484_3887	COG2223	nitrite transmembrane transporter activity
M484_3888	COG2223	nitrite transmembrane transporter activity
M484_389	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M484_3890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M484_3893	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M484_39	COG3217	Mosc domain protein beta barrel domain protein
M484_39	COG0633	Ferredoxin
M484_3902	COG3395	kinase activity
M484_3903	COG0235	Class ii aldolase
M484_3904	COG1349	DNA-binding transcription factor activity
M484_3905	COG3622	Belongs to the hyi family
M484_3909	COG4386	tail sheath protein
M484_3918	COG3299	homolog of phage Mu protein gp47
M484_392	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M484_3922	COG1737	Transcriptional regulator
M484_3924	COG2723	6-phospho-beta-galactosidase activity
M484_3928	COG3157	Type VI secretion system effector, Hcp
M484_3931	COG3083	sulfuric ester hydrolase activity
M484_3932	COG3082	Protein of unknown function (DUF1414)
M484_3934	COG1943	Transposase
M484_3936	COG1061	Type III restriction enzyme res subunit
M484_3937	COG1187	pseudouridine synthase activity
M484_3938	COG2814	Major facilitator Superfamily
M484_3940	COG4172	Belongs to the ABC transporter superfamily
M484_3941	COG4239	(ABC) transporter, permease
M484_3942	COG4174	ABC transporter (Permease)
M484_3943	COG4166	transmembrane transport
M484_3944	COG2200	EAL domain
M484_3946	COG0791	NLP P60 protein
M484_3947	COG0671	phosphoesterase, PA-phosphatase related
M484_3948	COG0523	cobalamin synthesis protein
M484_3950	COG2186	Transcriptional regulator
M484_3951	COG0246	Mannitol dehydrogenase
M484_3952	COG1312	Catalyzes the dehydration of D-mannonate
M484_3956	COG1028	Short-chain dehydrogenase reductase Sdr
M484_396	COG1126	abc transporter atp-binding protein
M484_3961	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M484_3963	COG1129	ABC transporter
M484_3964	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_3965	COG0494	nUDIX hydrolase
M484_3967	COG1105	Belongs to the carbohydrate kinase PfkB family
M484_3968	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M484_3968	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M484_3968	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M484_3969	COG3710	Transcriptional regulator
M484_397	COG0765	amino acid transport
M484_3972	COG3121	Chaperone
M484_3973	COG3188	usher protein
M484_3975	COG2855	membrane
M484_3976	COG0583	DNA-binding transcription factor activity
M484_3978	COG0833	amino acid
M484_398	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M484_3980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M484_3982	COG4771	TonB-dependent receptor
M484_3983	COG0625	glutathione transferase activity
M484_3989	COG2011	ABC-type metal ion transport system permease component
M484_3990	COG1686	Belongs to the peptidase S11 family
M484_3991	COG0814	amino acid
M484_3992	COG1349	DNA-binding transcription factor activity
M484_3993	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M484_3994	COG0671	phosphoesterase, PA-phosphatase related
M484_3996	COG2985	domain, Protein
M484_3996	COG0569	domain protein
M484_3997	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M484_4	COG1882	Formate acetyltransferase
M484_4000	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M484_4001	COG3842	ATPase activity
M484_4002	COG1176	ABC-type spermidine putrescine transport system, permease component I
M484_4003	COG1177	transmembrane transport
M484_4006	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M484_4012	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M484_4013	COG1120	ATPase activity
M484_4017	COG4160	amino acid transport
M484_4018	COG4215	(ABC) transporter
M484_4019	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M484_4020	COG1126	abc transporter atp-binding protein
M484_4021	COG1605	Chorismate mutase
M484_4023	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M484_4024	COG0702	epimerase
M484_4025	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M484_4026	COG0028	Belongs to the TPP enzyme family
M484_4027	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M484_4029	COG2431	L-lysine efflux transmembrane transporter activity
M484_4030	COG3593	DNA synthesis involved in DNA repair
M484_4031	COG2990	Protein conserved in bacteria
M484_4032	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M484_4035	COG1278	Cold shock
M484_4037	COG0542	response to heat
M484_4039	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M484_404	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M484_4041	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M484_4043	COG0492	ferredoxin-NADP+ reductase activity
M484_4045	COG1674	ftsk spoiiie
M484_4045	COG3107	peptidoglycan biosynthetic process
M484_4048	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M484_4064	COG3328	transposase activity
M484_4069	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M484_4069	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M484_4075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M484_408	COG1063	alcohol dehydrogenase
M484_409	COG1879	ABC-type sugar transport system periplasmic component
M484_4091	COG1475	DNA binding
M484_4094	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M484_4095	COG5301	cellulose 1,4-beta-cellobiosidase activity
M484_4095	COG5301	cellulose 1,4-beta-cellobiosidase activity
M484_41	COG0488	(ABC) transporter
M484_4102	COG3941	tape measure
M484_411	COG1129	ABC transporter
M484_412	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_4120	COG1475	DNA binding
M484_4121	COG1475	DNA binding
M484_4122	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M484_4128	COG1943	Transposase
M484_413	COG1609	Transcriptional regulator
M484_4132	COG1943	Transposase
M484_4134	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M484_4135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M484_414	COG0583	DNA-binding transcription factor activity
M484_415	COG0473	3-isopropylmalate dehydrogenase activity
M484_4151	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M484_4153	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M484_416	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M484_417	COG4638	Rieske (2fe-2S)
M484_4177	COG3328	transposase activity
M484_418	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M484_4188	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M484_4189	COG4790	Type iii secretion
M484_419	COG2831	hemolysin activation secretion protein
M484_4190	COG4794	Type iii secretion
M484_4191	COG4791	protein targeting
M484_4192	COG4792	protein secretion
M484_4194	COG2207	Transcriptional regulator
M484_42	COG2995	paraquat-inducible protein a
M484_420	COG3210	domain, Protein
M484_4203	COG4669	(LipO)protein
M484_4205	COG1317	bacterial-type flagellum organization
M484_4206	COG5599	Phosphatase
M484_4207	COG2963	transposase activity
M484_4208	COG2801	Transposase and inactivated derivatives
M484_4213	COG2801	Transposase and inactivated derivatives
M484_4215	COG0515	serine threonine protein kinase
M484_423	COG3210	domain, Protein
M484_4232	COG2801	Transposase and inactivated derivatives
M484_4237	COG2801	Transposase and inactivated derivatives
M484_4242	COG2801	Transposase and inactivated derivatives
M484_4244	COG5599	Phosphatase
M484_4246	COG3609	addiction module antidote protein, CC2985 family
M484_4248	COG1475	DNA binding
M484_4249	COG1192	Involved in chromosome partitioning
M484_4251	COG2801	Transposase and inactivated derivatives
M484_4255	COG3177	Filamentation induced by cAMP protein fic
M484_4260	COG4886	Leucine-rich repeat (LRR) protein
M484_4262	COG3328	transposase activity
M484_4265	COG0457	Tetratricopeptide repeat
M484_4269	COG4789	Type iii secretion
M484_427	COG3210	domain, Protein
M484_429	COG3328	transposase activity
M484_43	COG3008	intermembrane lipid transfer
M484_43	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M484_430	COG3842	ATPase activity
M484_432	COG1609	Transcriptional regulator
M484_435	COG0395	ABC-type sugar transport system, permease component
M484_436	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
M484_44	COG3009	Protein conserved in bacteria
M484_440	COG0668	transmembrane transport
M484_441	COG1518	maintenance of DNA repeat elements
M484_442	COG1203	CRISPR-associated helicase, Cas3
M484_447	COG0667	Aldo Keto reductase
M484_449	COG0477	Major facilitator Superfamily
M484_451	COG0583	DNA-binding transcription factor activity
M484_452	COG3916	Acyl-homoserine-lactone synthase
M484_453	COG2771	luxR family
M484_457	COG0628	permease
M484_46	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M484_461	COG3328	transposase activity
M484_464	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M484_465	COG1530	ribonuclease E activity
M484_466	COG0564	pseudouridine synthase activity
M484_468	COG1399	metal-binding, possibly nucleic acid-binding protein
M484_469	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M484_47	COG1737	Transcriptional regulator
M484_473	COG1028	Short-chain dehydrogenase reductase Sdr
M484_475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M484_476	COG1943	Transposase
M484_477	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M484_478	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M484_480	COG0470	DNA polymerase III
M484_481	COG0084	hydrolase, TatD family'
M484_482	COG1263	PTS System
M484_482	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M484_483	COG1943	Transposase
M484_484	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M484_485	COG0537	adenosine 5'-monophosphoramidase activity
M484_486	COG5633	Lipoprotein
M484_489	COG1472	Belongs to the glycosyl hydrolase 3 family
M484_49	COG0560	Phosphoserine phosphatase
M484_491	COG1252	NADH dehydrogenase
M484_494	COG3328	transposase activity
M484_495	COG3134	Outer membrane lipoprotein
M484_496	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M484_497	COG4591	ABC-type transport system involved in lipoprotein release permease component
M484_499	COG4591	ABC-type transport system involved in lipoprotein release permease component
M484_5	COG2116	formate transmembrane transporter activity
M484_50	COG0590	tRNA wobble adenosine to inosine editing
M484_501	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M484_503	COG2850	peptidyl-arginine hydroxylation
M484_505	COG0745	RESPONSE REGULATOR receiver
M484_507	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M484_511	COG1187	pseudouridine synthase activity
M484_512	COG0538	isocitrate dehydrogenase activity
M484_515	COG0840	transmembrane signaling receptor activity
M484_516	COG0702	epimerase
M484_517	COG1733	regulation of RNA biosynthetic process
M484_522	COG1522	sequence-specific DNA binding
M484_525	COG3321	synthase
M484_525	COG1028	Short-chain dehydrogenase reductase Sdr
M484_525	COG0604	alcohol dehydrogenase
M484_527	COG1278	Cold shock
M484_529	COG0840	transmembrane signaling receptor activity
M484_530	COG0840	transmembrane signaling receptor activity
M484_531	COG1285	pathogenesis
M484_536	COG1360	Flagellar Motor Protein
M484_537	COG0643	Histidine kinase
M484_537	COG2198	Histidine kinase
M484_538	COG0835	chemotaxis
M484_539	COG2271	Major facilitator Superfamily
M484_540	COG0251	oxidation-reduction process
M484_542	COG2964	Protein conserved in bacteria
M484_546	COG0840	transmembrane signaling receptor activity
M484_547	COG0840	transmembrane signaling receptor activity
M484_548	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M484_550	COG0745	RESPONSE REGULATOR receiver
M484_551	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M484_552	COG3023	N-Acetylmuramoyl-L-alanine amidase
M484_554	COG5295	Hep Hag repeat protein
M484_557	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M484_56	COG1943	Transposase
M484_57	COG2205	protein histidine kinase activity
M484_570	COG3121	Chaperone
M484_574	COG3008	intermembrane lipid transfer
M484_575	COG2995	paraquat-inducible protein a
M484_576	COG1956	GAF domain-containing protein
M484_578	COG0793	Belongs to the peptidase S41A family
M484_58	COG3170	Tfp pilus assembly protein FimV
M484_581	COG3539	Fimbrial protein
M484_582	COG3121	Chaperone
M484_585	COG3121	Chaperone
M484_586	COG2814	Major facilitator Superfamily
M484_587	COG0823	Involved in the tonB-independent uptake of proteins
M484_589	COG3023	N-Acetylmuramoyl-L-alanine amidase
M484_59	COG2204	response regulator
M484_591	COG1988	membrane-bound metal-dependent
M484_592	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M484_593	COG1653	transport
M484_594	COG3842	ATPase activity
M484_595	COG0395	ABC-type sugar transport system, permease component
M484_596	COG1175	transmembrane transport
M484_598	COG1028	Short-chain dehydrogenase reductase Sdr
M484_6	COG1944	ATP diphosphatase activity
M484_60	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M484_60	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M484_600	COG1917	Cupin 2, conserved barrel domain protein
M484_601	COG3328	transposase activity
M484_602	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M484_605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M484_606	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M484_607	COG1121	(ABC) transporter
M484_608	COG0803	Belongs to the bacterial solute-binding protein 9 family
M484_61	COG0347	Belongs to the P(II) protein family
M484_612	COG4249	Peptidase C14 caspase catalytic subunit p20
M484_617	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M484_618	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M484_618	COG0072	phenylalanine-tRNA ligase activity
M484_619	COG0776	regulation of translation
M484_62	COG2188	Transcriptional regulator
M484_622	COG0386	Belongs to the glutathione peroxidase family
M484_623	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
M484_631	COG0791	NLP P60 protein
M484_636	COG0574	Belongs to the PEP-utilizing enzyme family
M484_636	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M484_637	COG0628	permease
M484_638	COG0277	FAD linked oxidase domain protein
M484_638	COG0247	lactate metabolic process
M484_639	COG2050	protein possibly involved in aromatic compounds catabolism
M484_640	COG0316	Belongs to the HesB IscA family
M484_641	COG0719	Fe-S assembly protein
M484_642	COG0396	ATPase activity
M484_643	COG0719	Fe-S assembly protein
M484_646	COG1388	LysM domain
M484_646	COG1376	ErfK ybiS ycfS ynhG family protein
M484_649	COG4238	major outer membrane lipoprotein
M484_65	COG1017	nitric oxide dioxygenase activity
M484_65	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M484_654	COG0307	riboflavin synthase, alpha
M484_655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M484_656	COG2814	Major facilitator Superfamily
M484_657	COG0583	DNA-binding transcription factor activity
M484_660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M484_661	COG0791	NLP P60 protein
M484_663	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M484_665	COG0346	lactoylglutathione lyase activity
M484_667	COG1902	pentaerythritol trinitrate reductase activity
M484_668	COG1309	transcriptional regulator
M484_669	COG2194	sulfuric ester hydrolase activity
M484_670	COG3313	Fe-S protein
M484_671	COG4989	oxidoreductase activity
M484_672	COG3133	Outer membrane lipoprotein
M484_674	COG3895	Periplasmic Protein
M484_678	COG0625	glutathione transferase activity
M484_68	COG3711	transcriptional antiterminator
M484_681	COG3104	oligopeptide transport
M484_683	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M484_683	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M484_684	COG4172	Belongs to the ABC transporter superfamily
M484_686	COG4171	peptide transport system, permease
M484_687	COG4168	peptide transport system, permease
M484_688	COG4166	transmembrane transport
M484_689	COG1943	Transposase
M484_69	COG2814	Major facilitator Superfamily
M484_690	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M484_691	COG1842	Phage shock protein A
M484_693	COG1983	PspC domain protein
M484_695	COG3106	COG3106 Predicted ATPase
M484_7	COG0252	asparaginase activity
M484_70	COG3683	transport system, periplasmic component
M484_700	COG1943	Transposase
M484_703	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M484_704	COG4948	Mandelate Racemase Muconate Lactonizing
M484_705	COG2866	Carboxypeptidase
M484_706	COG4166	transmembrane transport
M484_709	COG2755	lipolytic protein G-D-S-L family
M484_709	COG0657	acetylesterase activity
M484_71	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
M484_712	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M484_712	COG1013	pyruvate-flavodoxin oxidoreductase activity
M484_712	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M484_712	COG0674	pyruvate-flavodoxin oxidoreductase activity
M484_714	COG1285	pathogenesis
M484_715	COG3042	response to heat
M484_716	COG3187	Heat shock protein
M484_717	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M484_718	COG2911	Protein conserved in bacteria
M484_72	COG0483	inositol monophosphate 1-phosphatase activity
M484_720	COG3784	Protein of unknown function (DUF1318)
M484_721	COG0246	Mannitol dehydrogenase
M484_722	COG2390	Transcriptional regulator
M484_724	COG1643	Atp-dependent helicase
M484_727	COG3591	Belongs to the peptidase S1B family
M484_729	COG3038	cytochrome b561
M484_733	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M484_734	COG2205	protein histidine kinase activity
M484_735	COG0745	RESPONSE REGULATOR receiver
M484_737	COG0531	amino acid
M484_739	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M484_740	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M484_741	COG0589	response to stress
M484_742	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M484_743	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M484_746	COG1011	Hydrolase
M484_747	COG0440	acetolactate synthase activity
M484_748	COG0028	Belongs to the TPP enzyme family
M484_75	COG1104	cysteine desulfurase activity
M484_754	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M484_756	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M484_757	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M484_758	COG1879	ABC-type sugar transport system periplasmic component
M484_76	COG0822	iron-sulfur transferase activity
M484_760	COG1609	Transcriptional regulator
M484_762	COG0038	chloride channel
M484_763	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M484_765	COG1940	carbohydrate kinase activity
M484_766	COG0583	DNA-binding transcription factor activity
M484_767	COG2814	Major facilitator Superfamily
M484_769	COG0114	fumarate hydratase activity
M484_771	COG5339	Protein conserved in bacteria
M484_773	COG0385	Bile acid
M484_774	COG0673	inositol 2-dehydrogenase activity
M484_776	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_777	COG1172	Belongs to the binding-protein-dependent transport system permease family
M484_779	COG1879	ABC-type sugar transport system periplasmic component
M484_783	COG2274	protein secretion by the type I secretion system
M484_784	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M484_79	COG0443	Heat shock 70 kDa protein
M484_791	COG2207	Transcriptional regulator
M484_791	COG3708	Transcriptional regulator
M484_792	COG4658	electron transport chain
M484_793	COG4659	FMN binding
M484_795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M484_796	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M484_797	COG2271	Major facilitator Superfamily
M484_799	COG1966	Carbon starvation protein
M484_8	COG5295	Hep Hag repeat protein
M484_8	COG5295	Hep Hag repeat protein
M484_80	COG0633	Ferredoxin
M484_800	COG2879	small protein
M484_801	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M484_805	COG0023	Translation Initiation Factor
M484_808	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M484_809	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M484_81	COG2975	iron-sulfur cluster assembly
M484_810	COG0671	phosphoesterase, PA-phosphatase related
M484_811	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M484_812	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M484_814	COG0583	DNA-binding transcription factor activity
M484_815	COG1943	Transposase
M484_816	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M484_819	COG0616	signal peptide processing
M484_820	COG1028	Short-chain dehydrogenase reductase Sdr
M484_822	COG1187	pseudouridine synthase activity
M484_823	COG0009	L-threonylcarbamoyladenylate synthase
M484_826	COG0512	Glutamine amidotransferase of anthranilate synthase
M484_828	COG0134	indole-3-glycerol-phosphate synthase activity
M484_828	COG0135	phosphoribosylanthranilate isomerase activity
M484_832	COG3047	cAMP biosynthetic process
M484_837	COG1607	acyl-coa hydrolase
M484_838	COG3328	transposase activity
M484_839	COG3328	transposase activity
M484_840	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M484_841	COG2350	Protein conserved in bacteria
M484_848	COG4608	Belongs to the ABC transporter superfamily
M484_849	COG0444	Belongs to the ABC transporter superfamily
M484_85	COG3468	outer membrane autotransporter barrel domain protein
M484_850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M484_851	COG0601	transmembrane transport
M484_853	COG2095	MarC family integral membrane protein
M484_854	COG1454	alcohol dehydrogenase
M484_854	COG1012	belongs to the aldehyde dehydrogenase family
M484_855	COG1435	thymidine kinase activity
M484_857	COG3328	transposase activity
M484_859	COG0745	RESPONSE REGULATOR receiver
M484_86	COG3468	outer membrane autotransporter barrel domain protein
M484_861	COG0788	formyltetrahydrofolate deformylase activity
M484_865	COG3328	transposase activity
M484_866	COG0583	DNA-binding transcription factor activity
M484_867	COG0708	Exodeoxyribonuclease III
M484_868	COG0494	nUDIX hydrolase
M484_870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M484_871	COG0709	Synthesizes selenophosphate from selenide and ATP
M484_872	COG0778	Nitroreductase
M484_873	COG0616	signal peptide processing
M484_874	COG0252	asparaginase activity
M484_875	COG1335	isochorismatase
M484_876	COG3139	Protein of unknown function (DUF1315)
M484_880	COG3713	MltA-interacting MipA family protein
M484_881	COG2766	serine protein kinase
M484_884	COG0583	DNA-binding transcription factor activity
M484_886	COG2814	Major facilitator Superfamily
M484_888	COG2719	SpoVR family
M484_894	COG1104	cysteine desulfurase activity
M484_912	COG1943	Transposase
M484_94	COG2976	Protein conserved in bacteria
M484_947	COG0582	viral genome integration into host DNA
M484_949	COG0179	Fumarylacetoacetate (FAA) hydrolase
M484_95	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M484_950	COG2951	lytic endotransglycosylase activity
M484_953	COG2894	cell division
M484_954	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M484_955	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M484_956	COG0318	PFAM AMP-dependent synthetase and ligase
M484_957	COG3065	identical protein binding
M484_959	COG1199	ATP-dependent helicase activity
M484_960	COG0251	oxidation-reduction process
M484_963	COG0800	Aldolase
M484_965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M484_966	COG1737	Transcriptional regulator
M484_967	COG0469	pyruvate kinase activity
M484_968	COG1560	Kdo2-lipid A biosynthetic process
M484_969	COG0739	heme binding
M484_970	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M484_972	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M484_977	COG0494	nUDIX hydrolase
M484_979	COG1801	Protein of unknown function DUF72
M484_98	COG1645	bacterial-type flagellum-dependent swarming motility
M484_980	COG3788	relative of glutathione S-transferase, MAPEG superfamily
M484_984	COG3102	Protein conserved in bacteria
M484_988	COG0728	peptidoglycan biosynthetic process
M484_989	COG0673	inositol 2-dehydrogenase activity
M484_990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M484_993	COG3381	protein complex oligomerization
M484_996	COG1940	carbohydrate kinase activity
M484_997	COG0584	glycerophosphoryl diester phosphodiesterase
M484_998	COG3842	ATPase activity
M484_999	COG1943	Transposase