locus-tag	class	description
CH58_1	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH58_10	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH58_100	COG0788	formyltetrahydrofolate deformylase activity
CH58_1002	COG3272	Protein of unknown function (DUF1722)
CH58_1004	COG5212	phosphodiesterase
CH58_1005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH58_1007	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH58_1008	COG1984	allophanate hydrolase subunit 2
CH58_101	COG3328	transposase activity
CH58_1019	COG0513	Belongs to the DEAD box helicase family
CH58_1021	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH58_1023	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH58_1024	COG3026	antisigma factor binding
CH58_1025	COG3086	response to oxidative stress
CH58_1028	COG0681	Belongs to the peptidase S26 family
CH58_103	COG0745	RESPONSE REGULATOR receiver
CH58_1034	COG0582	viral genome integration into host DNA
CH58_1035	COG2963	transposase activity
CH58_1037	COG0596	Alpha beta hydrolase
CH58_1041	COG0735	belongs to the Fur family
CH58_1046	COG1943	Transposase
CH58_1047	COG2190	(PTS) system
CH58_1047	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH58_1047	COG1263	PTS System
CH58_1049	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH58_1050	COG1846	Transcriptional regulator
CH58_1050	COG1940	carbohydrate kinase activity
CH58_1051	COG0647	UMP catabolic process
CH58_1052	COG0367	asparagine synthase
CH58_1059	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH58_106	COG1435	thymidine kinase activity
CH58_1061	COG1702	phosphate starvation-inducible protein PhoH
CH58_1063	COG4535	Mg2 and Co2 transporter CorC
CH58_1064	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH58_1066	COG0765	amino acid transport
CH58_1067	COG0765	amino acid transport
CH58_1068	COG1126	abc transporter atp-binding protein
CH58_1069	COG2888	peptidyl-tyrosine sulfation
CH58_1072	COG1466	dna polymerase III delta subunit
CH58_1074	COG0799	negative regulation of ribosome biogenesis
CH58_1076	COG0768	penicillin binding
CH58_1077	COG0772	Belongs to the SEDS family
CH58_1078	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH58_1081	COG1686	Belongs to the peptidase S11 family
CH58_1085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH58_1086	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH58_1087	COG1278	Cold shock
CH58_1088	COG1278	Cold shock
CH58_1089	COG2197	response regulator
CH58_1094	COG5265	(ABC) transporter
CH58_1096	COG3718	enzyme involved in inositol metabolism
CH58_1099	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH58_1100	COG0673	inositol 2-dehydrogenase activity
CH58_1101	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_1102	COG1129	ABC transporter
CH58_1103	COG1879	ABC-type sugar transport system periplasmic component
CH58_1104	COG0673	inositol 2-dehydrogenase activity
CH58_1105	COG0673	inositol 2-dehydrogenase activity
CH58_1106	COG3962	Belongs to the TPP enzyme family
CH58_1112	COG2373	Large extracellular alpha-helical protein
CH58_1113	COG4953	penicillin-binding protein 1C
CH58_1114	COG3328	transposase activity
CH58_1115	COG4953	penicillin-binding protein 1C
CH58_1116	COG3423	Transcriptional regulator
CH58_1125	COG2850	peptidyl-arginine hydroxylation
CH58_1126	COG3328	transposase activity
CH58_1127	COG3328	transposase activity
CH58_113	COG1454	alcohol dehydrogenase
CH58_113	COG1012	belongs to the aldehyde dehydrogenase family
CH58_1132	COG0656	L-ascorbic acid biosynthetic process
CH58_1133	COG0667	Aldo Keto reductase
CH58_114	COG2095	MarC family integral membrane protein
CH58_1140	COG0671	phosphoesterase, PA-phosphatase related
CH58_1140	COG2453	phosphatase
CH58_1141	COG2267	carboxylic ester hydrolase activity
CH58_1143	COG4589	Belongs to the CDS family
CH58_1144	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH58_1152	COG2501	S4 domain
CH58_1153	COG1943	Transposase
CH58_1156	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH58_1158	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH58_1159	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH58_116	COG0601	transmembrane transport
CH58_1160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH58_1161	COG4181	ATPase activity
CH58_1162	COG2755	lipolytic protein G-D-S-L family
CH58_1163	COG0300	oxidoreductase activity
CH58_1164	COG3118	belongs to the thioredoxin family
CH58_1165	COG0330	HflC and HflK could
CH58_1166	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH58_1167	COG0789	Transcriptional regulator
CH58_1168	COG2217	Heavy metal translocating P-type atpase
CH58_1169	COG3735	TraB family
CH58_117	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH58_1170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH58_1173	COG0737	Belongs to the 5'-nucleotidase family
CH58_1174	COG0737	Belongs to the 5'-nucleotidase family
CH58_1175	COG0737	Belongs to the 5'-nucleotidase family
CH58_1176	COG2223	nitrite transmembrane transporter activity
CH58_1177	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH58_1177	COG4651	solute:proton antiporter activity
CH58_1178	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH58_1179	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH58_118	COG0444	Belongs to the ABC transporter superfamily
CH58_1183	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH58_1184	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH58_1185	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH58_119	COG4608	Belongs to the ABC transporter superfamily
CH58_1194	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH58_1198	COG0543	2 iron, 2 sulfur cluster binding
CH58_1198	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH58_12	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH58_1204	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CH58_1206	COG2832	Protein of unknown function (DUF454)
CH58_1208	COG1196	nuclear chromosome segregation
CH58_1208	COG3264	Mechanosensitive ion channel
CH58_1212	COG3264	Mechanosensitive ion channel
CH58_1212	COG1196	nuclear chromosome segregation
CH58_1213	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH58_1214	COG1309	transcriptional regulator
CH58_1215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH58_1216	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH58_1218	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH58_1222	COG3695	enzyme binding
CH58_1223	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH58_1224	COG1946	Acyl-CoA thioesterase
CH58_1225	COG0004	ammonium transporteR
CH58_1226	COG0347	Belongs to the P(II) protein family
CH58_1227	COG1132	(ABC) transporter
CH58_1228	COG1132	(ABC) transporter
CH58_1229	COG1522	sequence-specific DNA binding
CH58_1232	COG4533	DNA binding
CH58_1234	COG0824	Thioesterase
CH58_1235	COG1555	photosystem II stabilization
CH58_1236	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH58_1237	COG0776	regulation of translation
CH58_1238	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH58_1243	COG0271	Belongs to the BolA IbaG family
CH58_1244	COG3056	Lipoprotein
CH58_1245	COG2223	nitrite transmembrane transporter activity
CH58_1247	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH58_1248	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH58_1249	COG1845	cytochrome c oxidase, subunit III
CH58_1250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH58_1252	COG2814	Major facilitator Superfamily
CH58_1254	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH58_1255	COG0693	protein deglycase activity
CH58_1258	COG0142	geranyltranstransferase activity
CH58_126	COG2350	Protein conserved in bacteria
CH58_1260	COG1943	Transposase
CH58_1261	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH58_1262	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH58_1265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH58_1265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH58_1269	COG1943	Transposase
CH58_1270	COG1943	Transposase
CH58_1271	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH58_1272	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH58_1273	COG1862	Preprotein translocase
CH58_1275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CH58_1276	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH58_1277	COG0450	alkyl hydroperoxide reductase
CH58_128	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH58_1281	COG0366	Alpha amylase catalytic
CH58_1283	COG1114	Component of the transport system for branched-chain amino acids
CH58_1285	COG5002	protein histidine kinase activity
CH58_1286	COG0745	RESPONSE REGULATOR receiver
CH58_1287	COG0420	3'-5' exonuclease activity
CH58_1288	COG0419	ATPase involved in DNA repair
CH58_129	COG3328	transposase activity
CH58_1292	COG0419	ATPase involved in DNA repair
CH58_1293	COG1940	carbohydrate kinase activity
CH58_1298	COG2226	methyltransferase
CH58_13	COG0739	heme binding
CH58_130	COG1607	acyl-coa hydrolase
CH58_1309	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH58_1313	COG1477	protein flavinylation
CH58_1317	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH58_1318	COG1805	sodium ion transport
CH58_1319	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH58_1320	COG0121	glutamine amidotransferase
CH58_1321	COG3034	peptidoglycan biosynthetic process
CH58_1323	COG1960	acyl-CoA dehydrogenase activity
CH58_1325	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH58_1329	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH58_1332	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH58_1341	COG2814	Major facilitator Superfamily
CH58_1342	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH58_1344	COG1846	Transcriptional regulator
CH58_1345	COG1566	PFAM secretion protein HlyD family protein
CH58_1346	COG2814	Major facilitator Superfamily
CH58_1347	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH58_1348	COG3118	belongs to the thioredoxin family
CH58_135	COG3047	cAMP biosynthetic process
CH58_1350	COG0045	succinate-CoA ligase (ADP-forming) activity
CH58_1350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH58_1350	COG1042	CoA-binding domain protein
CH58_1351	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH58_1352	COG5544	Lipoprotein
CH58_1359	COG0542	response to heat
CH58_1361	COG0564	pseudouridine synthase activity
CH58_1362	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH58_1363	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH58_1364	COG1943	Transposase
CH58_1365	COG1943	Transposase
CH58_1366	COG0077	Prephenate dehydratase
CH58_1366	COG1605	Chorismate mutase
CH58_1373	COG0529	Catalyzes the synthesis of activated sulfate
CH58_1376	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CH58_1381	COG4942	peptidase
CH58_1381	COG1388	LysM domain
CH58_1382	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH58_1384	COG0698	ribose 5-phosphate isomerase
CH58_1385	COG1063	alcohol dehydrogenase
CH58_1386	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_1387	COG2376	Dihydroxyacetone kinase
CH58_139	COG0135	phosphoribosylanthranilate isomerase activity
CH58_139	COG0134	indole-3-glycerol-phosphate synthase activity
CH58_1390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH58_1394	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH58_1395	COG1858	cytochrome C peroxidase
CH58_1397	COG4771	TonB-dependent receptor
CH58_14	COG1560	Kdo2-lipid A biosynthetic process
CH58_1400	COG0024	Methionine aminopeptidase
CH58_1402	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH58_1402	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH58_1403	COG1070	Carbohydrate kinase
CH58_1404	COG3623	hexulose-6-phosphate isomerase
CH58_1405	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_1406	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_1407	COG1129	ABC transporter
CH58_1408	COG1943	Transposase
CH58_141	COG0512	Glutamine amidotransferase of anthranilate synthase
CH58_1410	COG1349	DNA-binding transcription factor activity
CH58_1411	COG0235	Class ii aldolase
CH58_1412	COG0243	molybdopterin cofactor binding
CH58_1413	COG0437	4 iron, 4 sulfur cluster binding
CH58_1414	COG3302	dmso reductase anchor subunit
CH58_1415	COG3381	protein complex oligomerization
CH58_1416	COG3038	cytochrome b561
CH58_1417	COG3783	Cytochrome b(562)
CH58_1421	COG1129	ABC transporter
CH58_1422	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_1423	COG3959	Transketolase, thiamine diphosphate binding domain
CH58_1424	COG3958	Transketolase
CH58_1425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH58_1432	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH58_1433	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH58_1438	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH58_1439	COG1238	metal cluster binding
CH58_144	COG0009	L-threonylcarbamoyladenylate synthase
CH58_1440	COG2918	glutathione biosynthetic process
CH58_1442	COG1943	Transposase
CH58_1443	COG4536	flavin adenine dinucleotide binding
CH58_1444	COG4137	Cytochrome C assembly protein
CH58_1445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH58_145	COG1187	pseudouridine synthase activity
CH58_1450	COG1943	Transposase
CH58_1451	COG3137	Salt-induced outer membrane protein
CH58_1452	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH58_1453	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH58_1454	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH58_1455	COG3279	Response regulator of the LytR AlgR family
CH58_1456	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH58_1457	COG0287	Prephenate dehydrogenase
CH58_1457	COG1605	Chorismate mutase
CH58_1458	COG0077	Prephenate dehydratase
CH58_1458	COG1605	Chorismate mutase
CH58_147	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_1471	COG0720	synthase
CH58_1472	COG0602	queuosine metabolic process
CH58_1476	COG3956	TIGRFAM MazG family protein
CH58_1477	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH58_1478	COG3437	response regulator, receiver
CH58_1478	COG2205	protein histidine kinase activity
CH58_1478	COG3850	Histidine kinase
CH58_1478	COG4999	Histidine kinase
CH58_1479	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH58_148	COG0616	signal peptide processing
CH58_1483	COG2860	membrane
CH58_1487	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH58_1488	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH58_1489	COG1120	ATPase activity
CH58_1490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH58_1491	COG1643	Atp-dependent helicase
CH58_1492	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CH58_1494	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH58_1495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH58_1496	COG0617	tRNA 3'-terminal CCA addition
CH58_1497	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH58_15	COG0469	pyruvate kinase activity
CH58_1501	COG0726	polysaccharide deacetylase
CH58_1503	COG0842	Transport permease protein
CH58_1504	COG1131	(ABC) transporter
CH58_1505	COG0288	reversible hydration of carbon dioxide
CH58_1506	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH58_1507	COG2132	Multicopper oxidase
CH58_151	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH58_1511	COG0697	spore germination
CH58_1513	COG1049	propionate catabolic process, 2-methylcitrate cycle
CH58_1514	COG1943	Transposase
CH58_1515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH58_1516	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH58_1517	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH58_1518	COG2186	Transcriptional regulator
CH58_1519	COG1113	amino acid transport
CH58_152	COG0583	DNA-binding transcription factor activity
CH58_1520	COG3725	Membrane protein required for beta-lactamase induction
CH58_1521	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH58_1523	COG4969	Belongs to the N-Me-Phe pilin family
CH58_1524	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH58_1525	COG1459	type II secretion system
CH58_1527	COG0237	dephospho-CoA kinase activity
CH58_1534	COG0582	viral genome integration into host DNA
CH58_1536	COG0795	lipopolysaccharide-transporting ATPase activity
CH58_1537	COG0795	lipopolysaccharide-transporting ATPase activity
CH58_1539	COG2927	DNA polymerase III (CHI subunit)
CH58_154	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CH58_1540	COG0525	valine-tRNA ligase activity
CH58_1542	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH58_1543	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CH58_1544	COG2731	YhcH YjgK YiaL family protein
CH58_1547	COG0601	transmembrane transport
CH58_1548	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH58_1549	COG0444	Belongs to the ABC transporter superfamily
CH58_155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH58_1550	COG4608	Belongs to the ABC transporter superfamily
CH58_1554	COG2188	Transcriptional regulator
CH58_1555	COG3624	Phosphonate C-P lyase system protein PhnG
CH58_1556	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CH58_1557	COG3626	phosphonate metabolism
CH58_1558	COG3627	carbon phosphorus lyase activity
CH58_1559	COG4107	phosphonate C-P lyase system protein PhnK
CH58_156	COG0671	phosphoesterase, PA-phosphatase related
CH58_1560	COG4778	phosphonate C-P lyase system protein PhnL
CH58_1561	COG3454	Phosphonate metabolism
CH58_1562	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CH58_1563	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CH58_1564	COG0702	epimerase
CH58_1567	COG3842	ATPase activity
CH58_1568	COG0395	ABC-type sugar transport system, permease component
CH58_157	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH58_1570	COG1653	transport
CH58_1574	COG3153	acetyltransferase
CH58_1579	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH58_158	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH58_1582	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH58_1585	COG0513	Belongs to the DEAD box helicase family
CH58_1588	COG2801	Transposase and inactivated derivatives
CH58_1591	COG2423	ornithine cyclodeaminase activity
CH58_1592	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH58_1593	COG0823	Involved in the tonB-independent uptake of proteins
CH58_1594	COG0823	Involved in the tonB-independent uptake of proteins
CH58_1595	COG5645	(Lipo)protein
CH58_1599	COG3977	Valine--pyruvate aminotransferase
CH58_16	COG1737	Transcriptional regulator
CH58_1601	COG0366	Alpha amylase catalytic
CH58_1604	COG2885	chlorophyll binding
CH58_1606	COG2818	Glycosylase
CH58_161	COG0023	Translation Initiation Factor
CH58_1611	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH58_1611	COG2213	PTS system mannitol-specific
CH58_1613	COG3722	fumarate hydratase activity
CH58_1622	COG0840	transmembrane signaling receptor activity
CH58_1623	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH58_1625	COG3383	formate dehydrogenase (NAD+) activity
CH58_1625	COG0243	molybdopterin cofactor binding
CH58_1626	COG3383	formate dehydrogenase (NAD+) activity
CH58_1626	COG0243	molybdopterin cofactor binding
CH58_1627	COG0437	4 iron, 4 sulfur cluster binding
CH58_1628	COG2864	formate dehydrogenase
CH58_1631	COG3276	selenocysteine insertion sequence binding
CH58_1638	COG2801	Transposase and inactivated derivatives
CH58_1640	COG3133	Outer membrane lipoprotein
CH58_1641	COG3133	Outer membrane lipoprotein
CH58_1646	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CH58_1647	COG1191	sigma factor activity
CH58_165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH58_1652	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CH58_1656	COG3710	Transcriptional regulator
CH58_166	COG2879	small protein
CH58_1660	COG1256	bacterial-type flagellum assembly
CH58_1662	COG1706	bacterial-type flagellum-dependent cell motility
CH58_1663	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CH58_1664	COG4786	Flagellar basal body rod
CH58_1665	COG4787	bacterial-type flagellum-dependent cell motility
CH58_1666	COG1749	Flagellar hook protein flgE
CH58_1667	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH58_1668	COG1558	bacterial-type flagellum-dependent cell motility
CH58_1669	COG1815	bacterial-type flagellum-dependent cell motility
CH58_167	COG1966	Carbon starvation protein
CH58_1670	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CH58_1683	COG2204	response regulator
CH58_1688	COG1987	bacterial-type flagellum assembly
CH58_1689	COG1684	flagellar biosynthetic protein fliR
CH58_169	COG2271	Major facilitator Superfamily
CH58_1690	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH58_1694	COG4592	Periplasmic binding protein
CH58_1698	COG1943	Transposase
CH58_17	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH58_170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH58_1701	COG4964	Belongs to the GSP D family
CH58_1702	COG4964	Belongs to the GSP D family
CH58_171	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH58_1712	COG0848	biopolymer transport protein
CH58_1714	COG0811	peptide transport
CH58_1715	COG0626	cystathionine gamma-synthase activity
CH58_1716	COG0586	Pfam SNARE associated Golgi protein
CH58_1717	COG2207	Transcriptional regulator
CH58_1718	COG1979	alcohol dehydrogenase
CH58_1719	COG0656	L-ascorbic acid biosynthetic process
CH58_1722	COG2132	Multicopper oxidase
CH58_1723	COG0204	Acyl-transferase
CH58_1724	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH58_1725	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH58_1726	COG0583	DNA-binding transcription factor activity
CH58_1727	COG0187	DNA topoisomerase II activity
CH58_1728	COG3150	esterase
CH58_1729	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH58_173	COG4659	FMN binding
CH58_1730	COG3151	Protein conserved in bacteria
CH58_1731	COG0494	nUDIX hydrolase
CH58_1732	COG1538	Outer membrane efflux protein
CH58_1735	COG0754	glutathionylspermidine amidase activity
CH58_1736	COG3384	dioxygenase
CH58_174	COG4658	electron transport chain
CH58_1740	COG0531	amino acid
CH58_1743	COG3025	triphosphatase activity
CH58_1744	COG4991	sh3 domain protein
CH58_1747	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH58_175	COG3708	Transcriptional regulator
CH58_175	COG2207	Transcriptional regulator
CH58_1751	COG0358	DNA primase activity
CH58_1752	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH58_1770	COG0251	oxidation-reduction process
CH58_1778	COG1289	transmembrane transporter activity
CH58_1782	COG0395	ABC-type sugar transport system, permease component
CH58_1784	COG1653	transport
CH58_1785	COG1609	Transcriptional regulator
CH58_1786	COG3459	Glycosyltransferase 36 associated
CH58_1787	COG3842	ATPase activity
CH58_1791	COG3210	domain, Protein
CH58_1793	COG3210	domain, Protein
CH58_1795	COG3210	domain, Protein
CH58_1796	COG2831	hemolysin activation secretion protein
CH58_1797	COG4245	von Willebrand factor, type A
CH58_1800	COG4245	von Willebrand factor, type A
CH58_1803	COG3247	response to pH
CH58_1804	COG1902	pentaerythritol trinitrate reductase activity
CH58_1804	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH58_1807	COG1451	nucleotide metabolic process
CH58_1808	COG0673	inositol 2-dehydrogenase activity
CH58_1811	COG1943	Transposase
CH58_1813	COG2721	sulfolactate sulfo-lyase activity
CH58_1814	COG0246	Mannitol dehydrogenase
CH58_1815	COG0246	Mannitol dehydrogenase
CH58_1817	COG2271	Major facilitator Superfamily
CH58_182	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH58_1820	COG0586	Pfam SNARE associated Golgi protein
CH58_1823	COG4575	ribosome binding
CH58_1824	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH58_1826	COG2259	Doxx family
CH58_1827	COG0435	Glutathione S-transferase
CH58_183	COG2274	protein secretion by the type I secretion system
CH58_1832	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH58_1835	COG0551	DNA topoisomerase type I activity
CH58_1837	COG0758	DNA mediated transformation
CH58_1841	COG0569	domain protein
CH58_1843	COG3036	rescue of stalled ribosome
CH58_1844	COG0789	Transcriptional regulator
CH58_1847	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH58_1850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH58_1851	COG0201	protein transport
CH58_1853	COG1841	ribosomal large subunit assembly
CH58_1861	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH58_1862	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH58_1864	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH58_1867	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH58_187	COG1879	ABC-type sugar transport system periplasmic component
CH58_1872	COG0051	transcription antitermination factor activity, RNA binding
CH58_1877	COG1943	Transposase
CH58_1880	COG0049	tRNA binding
CH58_1881	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH58_1885	COG2964	Protein conserved in bacteria
CH58_1886	COG0545	Peptidyl-prolyl cis-trans isomerase
CH58_1888	COG1047	Peptidyl-prolyl cis-trans
CH58_1889	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH58_189	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_1892	COG0488	(ABC) transporter
CH58_1893	COG0488	(ABC) transporter
CH58_1894	COG1216	Glycosyl transferase, family 2
CH58_1896	COG2175	clavaminate synthase activity
CH58_1897	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH58_1899	COG4521	taurine ABC transporter
CH58_19	COG0800	Aldolase
CH58_1901	COG0429	hydrolase of the alpha beta-hydrolase fold
CH58_1903	COG3954	Phosphoribulokinase
CH58_1905	COG1765	OsmC-like protein
CH58_1907	COG1289	transmembrane transporter activity
CH58_191	COG0673	inositol 2-dehydrogenase activity
CH58_1910	COG0433	COG0433 Predicted ATPase
CH58_1911	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH58_1912	COG1486	melibiose metabolic process
CH58_1916	COG0402	S-adenosylhomocysteine deaminase activity
CH58_1917	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH58_1918	COG2146	nitrite reductase [NAD(P)H] activity
CH58_192	COG0385	Bile acid
CH58_1921	COG0180	Tryptophanyl-tRNA synthetase
CH58_1922	COG0546	phosphoglycolate phosphatase activity
CH58_1923	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH58_1928	COG4796	Type ii and iii secretion system protein
CH58_1933	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH58_1934	COG0494	nUDIX hydrolase
CH58_1937	COG1011	Hydrolase
CH58_1938	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH58_194	COG5339	Protein conserved in bacteria
CH58_1942	COG0745	RESPONSE REGULATOR receiver
CH58_1943	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH58_1944	COG2183	response to ionizing radiation
CH58_1945	COG1918	ferrous iron import across plasma membrane
CH58_1952	COG1640	4-alpha-glucanotransferase
CH58_1953	COG0058	SHG alpha-glucan phosphorylase activity
CH58_1954	COG0058	SHG alpha-glucan phosphorylase activity
CH58_1958	COG1349	DNA-binding transcription factor activity
CH58_196	COG0114	fumarate hydratase activity
CH58_1962	COG2801	Transposase and inactivated derivatives
CH58_1963	COG3300	MHYT domain
CH58_1963	COG5001	Diguanylate cyclase
CH58_1965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH58_1973	COG1943	Transposase
CH58_1975	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CH58_1976	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH58_1977	COG4771	TonB-dependent receptor
CH58_198	COG2814	Major facilitator Superfamily
CH58_1984	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH58_1984	COG2226	methyltransferase
CH58_1984	COG3433	isochorismatase activity
CH58_1985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH58_1986	COG3433	isochorismatase activity
CH58_1986	COG2226	methyltransferase
CH58_1986	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH58_199	COG0583	DNA-binding transcription factor activity
CH58_1993	COG1132	(ABC) transporter
CH58_1997	COG2610	gluconate transmembrane transporter activity
CH58_2	COG1801	Protein of unknown function DUF72
CH58_200	COG1940	carbohydrate kinase activity
CH58_2001	COG3501	Rhs element vgr protein
CH58_2003	COG3209	COG3209 Rhs family protein
CH58_2006	COG0471	metal ion transport
CH58_2008	COG2801	Transposase and inactivated derivatives
CH58_202	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH58_2024	COG3501	Rhs element vgr protein
CH58_2027	COG3209	COG3209 Rhs family protein
CH58_203	COG1609	Transcriptional regulator
CH58_2033	COG3501	Rhs element vgr protein
CH58_2035	COG3209	COG3209 Rhs family protein
CH58_2045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CH58_2051	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CH58_2052	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH58_2053	COG1739	Uncharacterized protein family UPF0029
CH58_2054	COG1943	Transposase
CH58_2055	COG1739	Uncharacterized protein family UPF0029
CH58_2070	COG1943	Transposase
CH58_2072	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH58_2073	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH58_2074	COG1494	fructose-1,6-bisphosphatase
CH58_2076	COG3152	Membrane
CH58_2079	COG0583	DNA-binding transcription factor activity
CH58_208	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH58_2080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CH58_2081	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CH58_2082	COG0471	metal ion transport
CH58_2084	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH58_2089	COG3678	ATP-independent chaperone mediated protein folding
CH58_209	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH58_2090	COG0745	RESPONSE REGULATOR receiver
CH58_2091	COG2205	protein histidine kinase activity
CH58_2092	COG2169	Transcriptional regulator
CH58_2092	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH58_2093	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH58_2094	COG1045	serine acetyltransferase
CH58_2097	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH58_2098	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH58_2100	COG4942	peptidase
CH58_2101	COG2861	carbohydrate metabolic process
CH58_2102	COG2861	carbohydrate metabolic process
CH58_2104	COG0156	8-amino-7-oxononanoate synthase activity
CH58_2106	COG0859	PFAM glycosyl transferase family 9
CH58_2107	COG0859	PFAM glycosyl transferase family 9
CH58_2108	COG1519	Transferase
CH58_2112	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH58_2115	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH58_2120	COG1561	YicC-like family, N-terminal region
CH58_2121	COG2860	membrane
CH58_2125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH58_2126	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH58_2127	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH58_2128	COG0786	glutamate:sodium symporter activity
CH58_2129	COG2233	PERMEase
CH58_2130	COG2982	Protein involved in outer membrane biogenesis
CH58_2131	COG0456	acetyltransferase
CH58_2136	COG1295	ribonuclease BN
CH58_2137	COG1011	Hydrolase
CH58_2139	COG0174	glutamine synthetase
CH58_214	COG0028	Belongs to the TPP enzyme family
CH58_2140	COG1943	Transposase
CH58_2141	COG3852	Histidine kinase
CH58_2143	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH58_2146	COG1943	Transposase
CH58_2147	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH58_2147	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH58_2148	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH58_2149	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH58_215	COG0440	acetolactate synthase activity
CH58_2150	COG3084	Protein conserved in bacteria
CH58_2152	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH58_2153	COG3328	transposase activity
CH58_2159	COG2186	Transcriptional regulator
CH58_216	COG1011	Hydrolase
CH58_2161	COG0477	Major facilitator Superfamily
CH58_2162	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH58_2172	COG1522	sequence-specific DNA binding
CH58_2173	COG0716	FMN binding
CH58_2176	COG3312	ion transport
CH58_2186	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CH58_2187	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH58_2188	COG0573	inorganic phosphate transmembrane transporter activity
CH58_2189	COG0581	inorganic phosphate transmembrane transporter activity
CH58_2191	COG0704	Plays a role in the regulation of phosphate uptake
CH58_2193	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH58_2194	COG0765	amino acid transport
CH58_2195	COG0765	amino acid transport
CH58_2196	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH58_2197	COG2252	PERMEase
CH58_22	COG0251	oxidation-reduction process
CH58_220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH58_2202	COG0706	membrane insertase activity
CH58_2205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH58_2208	COG0592	DNA-directed DNA polymerase activity
CH58_2209	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH58_221	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH58_2210	COG0187	DNA topoisomerase II activity
CH58_2211	COG0561	phosphatase activity
CH58_2212	COG2801	Transposase and inactivated derivatives
CH58_2215	COG3274	enterobacterial common antigen metabolic process
CH58_2217	COG3188	usher protein
CH58_2218	COG3188	usher protein
CH58_2219	COG3188	usher protein
CH58_222	COG0589	response to stress
CH58_2220	COG3121	Chaperone
CH58_2222	COG1070	Carbohydrate kinase
CH58_2224	COG4213	ABC transporter substrate-binding protein
CH58_2226	COG4214	carbohydrate transport
CH58_2227	COG1609	Transcriptional regulator
CH58_2227	COG2207	Transcriptional regulator
CH58_2229	COG0582	viral genome integration into host DNA
CH58_223	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH58_2236	COG4604	ABC transporter, ATP-binding protein
CH58_2238	COG4605	iron ion homeostasis
CH58_224	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH58_2240	COG4607	ABC-type enterochelin transport system periplasmic component
CH58_2246	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH58_2249	COG2986	histidine ammonia-lyase
CH58_2253	COG2194	sulfuric ester hydrolase activity
CH58_2254	COG2197	response regulator
CH58_2255	COG3851	Histidine kinase
CH58_226	COG0531	amino acid
CH58_2263	COG0564	pseudouridine synthase activity
CH58_2264	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH58_2267	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CH58_2272	COG1943	Transposase
CH58_2273	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH58_2275	COG2966	Psort location CytoplasmicMembrane, score
CH58_2276	COG1280	lysine exporter protein (LysE YggA)
CH58_2277	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH58_2278	COG0505	Belongs to the CarA family
CH58_228	COG0745	RESPONSE REGULATOR receiver
CH58_2280	COG1943	Transposase
CH58_2282	COG1047	Peptidyl-prolyl cis-trans
CH58_2285	COG0196	riboflavin kinase activity
CH58_2287	COG0583	DNA-binding transcription factor activity
CH58_229	COG2205	protein histidine kinase activity
CH58_2291	COG1584	GPR1 FUN34 yaaH family protein
CH58_2294	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH58_23	COG1199	ATP-dependent helicase activity
CH58_230	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH58_2302	COG0745	RESPONSE REGULATOR receiver
CH58_2303	COG3045	CreA protein
CH58_2306	COG3708	Transcriptional regulator
CH58_2306	COG2207	Transcriptional regulator
CH58_2307	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH58_2309	COG0741	lytic transglycosylase activity
CH58_231	COG1943	Transposase
CH58_2312	COG2199	diguanylate cyclase activity
CH58_2313	COG2885	chlorophyll binding
CH58_2314	COG0488	(ABC) transporter
CH58_2315	COG0488	(ABC) transporter
CH58_2321	COG3162	membrane
CH58_2323	COG1301	dicarboxylic acid transport
CH58_2345	COG2391	methyltransferase activity
CH58_2346	COG0425	Belongs to the sulfur carrier protein TusA family
CH58_2347	COG0583	DNA-binding transcription factor activity
CH58_2348	COG0814	amino acid
CH58_2349	COG0626	cystathionine gamma-synthase activity
CH58_235	COG3038	cytochrome b561
CH58_2351	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH58_2352	COG4558	Periplasmic binding protein
CH58_2353	COG3720	iron ion transport
CH58_2354	COG4771	TonB-dependent receptor
CH58_2355	COG0702	epimerase
CH58_2356	COG3721	Heme iron utilization protein
CH58_2361	COG1358	cellular component organization or biogenesis
CH58_237	COG3591	Belongs to the peptidase S1B family
CH58_2373	COG3121	Chaperone
CH58_2382	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH58_2384	COG0735	belongs to the Fur family
CH58_2385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH58_2388	COG0305	Participates in initiation and elongation during chromosome replication
CH58_2389	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH58_2390	COG1448	Aminotransferase
CH58_2391	COG2315	Protein conserved in bacteria
CH58_2392	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH58_2393	COG0629	single-stranded DNA binding
CH58_2395	COG1454	alcohol dehydrogenase
CH58_2398	COG1454	alcohol dehydrogenase
CH58_240	COG1643	Atp-dependent helicase
CH58_2411	COG1309	transcriptional regulator
CH58_2412	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH58_2412	COG0493	'glutamate synthase
CH58_2413	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH58_2414	COG3383	formate dehydrogenase (NAD+) activity
CH58_2417	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH58_2425	COG2076	Multidrug Resistance protein
CH58_2426	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH58_2428	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH58_2429	COG1053	succinate dehydrogenase
CH58_2431	COG3264	Mechanosensitive ion channel
CH58_2431	COG1511	domain protein
CH58_2434	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH58_2438	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH58_2439	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH58_2439	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH58_2440	COG0802	atpase or kinase
CH58_2441	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH58_2445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH58_2446	COG0330	HflC and HflK could
CH58_2447	COG0330	HflC and HflK could
CH58_2448	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH58_2451	COG0557	exoribonuclease II activity
CH58_2452	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH58_2453	COG1960	acyl-CoA dehydrogenase activity
CH58_2454	COG3650	response to hydrogen peroxide
CH58_2458	COG1401	restriction endodeoxyribonuclease activity
CH58_246	COG1643	Atp-dependent helicase
CH58_2460	COG2963	transposase activity
CH58_2470	COG4269	membrane
CH58_2472	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH58_2473	COG2207	Transcriptional regulator
CH58_2474	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH58_2475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH58_2476	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH58_2476	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH58_2476	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH58_248	COG2390	Transcriptional regulator
CH58_2484	COG2390	Transcriptional regulator
CH58_2485	COG2390	Transcriptional regulator
CH58_2487	COG0859	PFAM glycosyl transferase family 9
CH58_249	COG0246	Mannitol dehydrogenase
CH58_2490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH58_2491	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH58_2495	COG3706	GGDEF domain
CH58_2499	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH58_25	COG3065	identical protein binding
CH58_250	COG3784	Protein of unknown function (DUF1318)
CH58_2500	COG0456	acetyltransferase
CH58_2502	COG2823	Periplasmic or secreted lipoprotein
CH58_2504	COG4667	esterase of the alpha-beta hydrolase superfamily
CH58_2505	COG0084	hydrolase, TatD family'
CH58_2506	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH58_2507	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH58_2512	COG3726	membrane protein affecting hemolysin expression
CH58_2513	COG0560	Phosphoserine phosphatase
CH58_2517	COG0488	(ABC) transporter
CH58_252	COG2911	Protein conserved in bacteria
CH58_2522	COG2271	Major facilitator Superfamily
CH58_2524	COG1943	Transposase
CH58_2526	COG2831	hemolysin activation secretion protein
CH58_2528	COG0747	negative chemotaxis
CH58_2529	COG0601	transmembrane transport
CH58_253	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH58_2530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH58_2531	COG0444	Belongs to the ABC transporter superfamily
CH58_2532	COG4608	Belongs to the ABC transporter superfamily
CH58_2533	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CH58_2534	COG2200	EAL domain
CH58_2534	COG2199	diguanylate cyclase activity
CH58_2535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH58_254	COG3187	Heat shock protein
CH58_2540	COG0612	Peptidase, M16
CH58_2541	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH58_2542	COG1942	4-Oxalocrotonate Tautomerase
CH58_2543	COG2200	EAL domain
CH58_2544	COG2134	cdp-diacylglycerol pyrophosphatase
CH58_2545	COG2982	Protein involved in outer membrane biogenesis
CH58_2546	COG1295	ribonuclease BN
CH58_255	COG3042	response to heat
CH58_2551	COG1929	Belongs to the glycerate kinase type-1 family
CH58_2552	COG2610	gluconate transmembrane transporter activity
CH58_2553	COG3835	regulator
CH58_2554	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH58_2555	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH58_2556	COG0339	signal peptide processing
CH58_256	COG1285	pathogenesis
CH58_2560	COG0589	response to stress
CH58_2562	COG1943	Transposase
CH58_2563	COG0306	phosphate transporter
CH58_2564	COG2081	HI0933 family
CH58_2567	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_2568	COG1879	ABC-type sugar transport system periplasmic component
CH58_2570	COG0191	fructose-bisphosphate aldolase activity
CH58_2572	COG0745	RESPONSE REGULATOR receiver
CH58_2574	COG1741	Belongs to the pirin family
CH58_2575	COG1609	Transcriptional regulator
CH58_2576	COG2610	gluconate transmembrane transporter activity
CH58_2577	COG3265	gluconokinase activity
CH58_258	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH58_258	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH58_258	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH58_258	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH58_2581	COG2095	MarC family integral membrane protein
CH58_2582	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH58_2589	COG3275	phosphorelay sensor kinase activity
CH58_2594	COG0058	SHG alpha-glucan phosphorylase activity
CH58_2595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH58_2598	COG2801	Transposase and inactivated derivatives
CH58_26	COG0318	PFAM AMP-dependent synthetase and ligase
CH58_2603	COG0435	Glutathione S-transferase
CH58_2604	COG0583	DNA-binding transcription factor activity
CH58_2605	COG1741	Belongs to the pirin family
CH58_2606	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH58_261	COG0657	acetylesterase activity
CH58_261	COG2755	lipolytic protein G-D-S-L family
CH58_2610	COG2823	Periplasmic or secreted lipoprotein
CH58_2612	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH58_2613	COG5002	protein histidine kinase activity
CH58_2613	COG0784	Response regulator, receiver
CH58_2613	COG2198	Histidine kinase
CH58_2614	COG1242	4 iron, 4 sulfur cluster binding
CH58_2615	COG0070	glutamate synthase
CH58_2615	COG0069	glutamate synthase activity
CH58_2615	COG0067	glutamate synthase
CH58_2616	COG0493	'glutamate synthase
CH58_2618	COG2969	positive regulation of protein catabolic process
CH58_2619	COG0625	glutathione transferase activity
CH58_2622	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH58_2623	COG3105	Protein conserved in bacteria
CH58_2624	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH58_2625	COG1943	Transposase
CH58_2626	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH58_2628	COG5007	Belongs to the BolA IbaG family
CH58_2629	COG3113	response to antibiotic
CH58_2630	COG2854	intermembrane phospholipid transfer
CH58_2631	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH58_2632	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH58_2633	COG1127	ABC transporter
CH58_2634	COG0530	calcium, potassium:sodium antiporter activity
CH58_2635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH58_2635	COG0517	IMP dehydrogenase activity
CH58_2636	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH58_2637	COG3117	lipopolysaccharide transmembrane transporter activity
CH58_2638	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH58_2639	COG1137	ATPase activity
CH58_264	COG4166	transmembrane transport
CH58_2640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH58_2642	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH58_2644	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH58_2649	COG1609	Transcriptional regulator
CH58_265	COG2866	Carboxypeptidase
CH58_2650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH58_2650	COG1263	PTS System
CH58_2651	COG0366	Alpha amylase catalytic
CH58_2652	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH58_2653	COG3783	Cytochrome b(562)
CH58_2655	COG0312	modulator of DNA gyrase
CH58_2657	COG2732	(Barnase) inhibitor
CH58_266	COG4948	Mandelate Racemase Muconate Lactonizing
CH58_2660	COG1012	belongs to the aldehyde dehydrogenase family
CH58_2664	COG0583	DNA-binding transcription factor activity
CH58_267	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH58_2676	COG0312	modulator of DNA gyrase
CH58_2677	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH58_2678	COG3164	Protein of unknown function
CH58_2679	COG1530	ribonuclease E activity
CH58_268	COG1943	Transposase
CH58_2681	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH58_2682	COG1792	Involved in formation and maintenance of cell shape
CH58_2683	COG1077	Cell shape determining protein MreB Mrl
CH58_2684	COG2200	EAL domain
CH58_2684	COG2199	diguanylate cyclase activity
CH58_2685	COG0604	alcohol dehydrogenase
CH58_2686	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CH58_2689	COG0511	ligase activity, forming carbon-carbon bonds
CH58_2690	COG0439	Biotin carboxylase
CH58_2692	COG3924	membrane
CH58_2693	COG4145	pantothenate transmembrane transporter activity
CH58_2695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH58_2696	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH58_27	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH58_2700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH58_2702	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH58_2703	COG3133	Outer membrane lipoprotein
CH58_2704	COG1278	Cold shock
CH58_2705	COG1278	Cold shock
CH58_2706	COG1943	Transposase
CH58_2709	COG0625	glutathione transferase activity
CH58_2711	COG1069	ribulokinase activity
CH58_2713	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_2714	COG1129	ABC transporter
CH58_2716	COG1560	Kdo2-lipid A biosynthetic process
CH58_2718	COG0025	NhaP-type Na H and K H
CH58_2719	COG2252	PERMEase
CH58_2720	COG3077	Addiction module antitoxin, RelB DinJ family
CH58_2722	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH58_2724	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH58_2725	COG0431	NADPH-dependent FMN reductase
CH58_2727	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH58_2728	COG1869	D-ribose catabolic process
CH58_2729	COG1917	Cupin 2, conserved barrel domain protein
CH58_2729	COG2207	Transcriptional regulator
CH58_273	COG3106	COG3106 Predicted ATPase
CH58_2730	COG0673	inositol 2-dehydrogenase activity
CH58_2739	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH58_2740	COG0250	Participates in transcription elongation, termination and antitermination
CH58_2747	COG1943	Transposase
CH58_275	COG1983	PspC domain protein
CH58_2751	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH58_2753	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CH58_2758	COG1515	deoxyribonuclease V activity
CH58_2759	COG3068	Protein conserved in bacteria
CH58_2762	COG0151	Belongs to the GarS family
CH58_277	COG1842	Phage shock protein A
CH58_2771	COG2801	Transposase and inactivated derivatives
CH58_278	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH58_2782	COG3501	Rhs element vgr protein
CH58_279	COG1943	Transposase
CH58_2790	COG3047	cAMP biosynthetic process
CH58_2790	COG2885	chlorophyll binding
CH58_2794	COG0417	DNA replication proofreading
CH58_2795	COG0586	Pfam SNARE associated Golgi protein
CH58_2797	COG1178	ABC-type Fe3 transport system permease component
CH58_2798	COG4143	(ABC) transporter
CH58_28	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH58_280	COG4166	transmembrane transport
CH58_2801	COG2814	Major facilitator Superfamily
CH58_2804	COG2814	Major facilitator Superfamily
CH58_2807	COG0473	3-isopropylmalate dehydrogenase activity
CH58_2809	COG1943	Transposase
CH58_281	COG4168	peptide transport system, permease
CH58_2812	COG1022	Amp-dependent synthetase and ligase
CH58_2813	COG0028	Belongs to the TPP enzyme family
CH58_2815	COG1943	Transposase
CH58_2816	COG1609	Transcriptional regulator
CH58_282	COG4171	peptide transport system, permease
CH58_2820	COG3116	cell division
CH58_2821	COG0768	penicillin binding
CH58_2822	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH58_2823	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH58_2826	COG0772	Belongs to the SEDS family
CH58_2830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH58_2831	COG0849	cell division
CH58_2832	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH58_2837	COG0494	nUDIX hydrolase
CH58_284	COG4172	Belongs to the ABC transporter superfamily
CH58_285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH58_285	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH58_2850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH58_2851	COG2224	Isocitrate lyase
CH58_2853	COG1414	Transcriptional regulator
CH58_2854	COG1414	Transcriptional regulator
CH58_2859	COG0527	aspartate kinase activity
CH58_2862	COG3833	ABC-type maltose transport systems, permease component
CH58_2863	COG1175	transmembrane transport
CH58_287	COG3104	oligopeptide transport
CH58_2874	COG2801	Transposase and inactivated derivatives
CH58_2881	COG0195	Participates in both transcription termination and antitermination
CH58_2885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH58_2887	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH58_2888	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CH58_2890	COG1534	Rna-binding protein
CH58_2891	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH58_2892	COG2027	D-alanyl-D-alanine carboxypeptidase
CH58_2893	COG0745	RESPONSE REGULATOR receiver
CH58_2894	COG0642	Histidine kinase
CH58_2896	COG0697	spore germination
CH58_2899	COG0142	geranyltranstransferase activity
CH58_29	COG2894	cell division
CH58_2901	COG3423	Transcriptional regulator
CH58_2905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH58_2907	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH58_2908	COG2105	PFAM AIG2 family protein
CH58_2909	COG2911	Protein conserved in bacteria
CH58_2910	COG0729	surface antigen
CH58_2912	COG1253	flavin adenine dinucleotide binding
CH58_2914	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH58_2916	COG0737	Belongs to the 5'-nucleotidase family
CH58_2918	COG0545	Peptidyl-prolyl cis-trans isomerase
CH58_2919	COG3061	Opacity-associated protein A
CH58_2921	COG1943	Transposase
CH58_2923	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH58_2924	COG0360	Binds together with S18 to 16S ribosomal RNA
CH58_2926	COG1073	alpha beta
CH58_293	COG3895	Periplasmic Protein
CH58_2932	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CH58_2936	COG1629	transport
CH58_2941	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH58_2942	COG0678	peroxiredoxin activity
CH58_2942	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH58_295	COG3133	Outer membrane lipoprotein
CH58_2956	COG1879	ABC-type sugar transport system periplasmic component
CH58_2957	COG1129	ABC transporter
CH58_2958	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_2960	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_2961	COG3085	chromosome segregation
CH58_2964	COG3978	acetolactate synthase activity
CH58_2965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH58_297	COG4989	oxidoreductase activity
CH58_2973	COG0583	DNA-binding transcription factor activity
CH58_298	COG3313	Fe-S protein
CH58_2980	COG3121	Chaperone
CH58_2983	COG3121	Chaperone
CH58_2985	COG3328	transposase activity
CH58_2987	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH58_299	COG2194	sulfuric ester hydrolase activity
CH58_2992	COG3118	belongs to the thioredoxin family
CH58_2993	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH58_2994	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH58_2995	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH58_2996	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH58_2997	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH58_2998	COG1088	dTDP-glucose 4,6-dehydratase activity
CH58_2999	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH58_300	COG1309	transcriptional regulator
CH58_3000	COG0456	acetyltransferase
CH58_3001	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH58_3002	COG2244	polysaccharide biosynthetic process
CH58_3006	COG1113	amino acid transport
CH58_301	COG1902	pentaerythritol trinitrate reductase activity
CH58_3014	COG1943	Transposase
CH58_3015	COG3071	HemY protein
CH58_3016	COG2959	enzyme of heme biosynthesis
CH58_3017	COG1587	Uroporphyrinogen-III synthase
CH58_3019	COG3072	Adenylate cyclase
CH58_3021	COG5567	small periplasmic lipoprotein
CH58_3023	COG3159	Protein conserved in bacteria
CH58_3024	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH58_3025	COG1011	Hydrolase
CH58_3026	COG0210	DNA helicase
CH58_3028	COG5441	Belongs to the UPF0261 family
CH58_3029	COG5564	TIM-barrel signal transduction protein
CH58_303	COG0346	lactoylglutathione lyase activity
CH58_3030	COG0598	Magnesium transport protein CorA
CH58_3032	COG2050	protein possibly involved in aromatic compounds catabolism
CH58_3033	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CH58_3034	COG0514	ATP-dependent DNA helicase (RecQ)
CH58_3035	COG1280	lysine exporter protein (LysE YggA)
CH58_3036	COG1280	lysine exporter protein (LysE YggA)
CH58_3037	COG2267	carboxylic ester hydrolase activity
CH58_3038	COG0561	phosphatase activity
CH58_304	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH58_3040	COG0584	glycerophosphoryl diester phosphodiesterase
CH58_3041	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH58_3043	COG0247	lactate metabolic process
CH58_3045	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH58_3048	COG3714	YhhN family
CH58_305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH58_3051	COG3776	membrane
CH58_3052	COG0742	ribosomal rna small subunit methyltransferase
CH58_3053	COG0552	protein localization to endoplasmic reticulum
CH58_3053	COG0552	protein localization to endoplasmic reticulum
CH58_3054	COG2884	Cell division ATP-binding protein ftsE
CH58_3055	COG2177	Part of the ABC transporter FtsEX involved in
CH58_3057	COG1943	Transposase
CH58_3059	COG0683	leucine binding
CH58_3062	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH58_3063	COG4177	L-phenylalanine transmembrane transporter activity
CH58_3064	COG0411	ABC transporter
CH58_3065	COG0410	ABC transporter
CH58_307	COG0791	NLP P60 protein
CH58_3077	COG0584	glycerophosphoryl diester phosphodiesterase
CH58_3078	COG0679	Auxin Efflux Carrier
CH58_3079	COG0583	DNA-binding transcription factor activity
CH58_308	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH58_3082	COG0412	Dienelactone hydrolase
CH58_3083	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CH58_3085	COG1966	Carbon starvation protein
CH58_3086	COG0586	Pfam SNARE associated Golgi protein
CH58_3087	COG1322	Protein conserved in bacteria
CH58_3091	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH58_3093	COG0805	protein transport
CH58_3099	COG1575	Belongs to the MenA family. Type 1 subfamily
CH58_3102	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH58_3103	COG1609	Transcriptional regulator
CH58_3105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH58_3107	COG4682	membrane
CH58_3109	COG0626	cystathionine gamma-synthase activity
CH58_311	COG0583	DNA-binding transcription factor activity
CH58_3110	COG0626	cystathionine gamma-synthase activity
CH58_3111	COG0460	homoserine dehydrogenase
CH58_3111	COG0527	aspartate kinase activity
CH58_3113	COG2801	Transposase and inactivated derivatives
CH58_3115	COG2211	Major facilitator Superfamily
CH58_312	COG2814	Major facilitator Superfamily
CH58_3125	COG3916	Acyl-homoserine-lactone synthase
CH58_3126	COG2771	luxR family
CH58_313	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH58_314	COG0307	riboflavin synthase, alpha
CH58_3147	COG1662	PFAM IS1 transposase
CH58_3151	COG1982	Orn Lys Arg decarboxylase major
CH58_3152	COG1879	ABC-type sugar transport system periplasmic component
CH58_3153	COG1129	ABC transporter
CH58_3154	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_3155	COG4774	siderophore transport
CH58_3159	COG1194	a g-specific adenine glycosylase
CH58_3161	COG3171	Protein conserved in bacteria
CH58_3162	COG2066	Belongs to the glutaminase family
CH58_3167	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH58_3168	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH58_3170	COG0762	integral membrane protein
CH58_3171	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH58_3172	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH58_3173	COG2805	Type II/IV secretion system protein
CH58_3175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH58_3178	COG0189	ligase activity
CH58_3179	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH58_3180	COG2356	endonuclease I
CH58_3184	COG1166	arginine decarboxylase activity
CH58_3185	COG1943	Transposase
CH58_3187	COG0501	Belongs to the peptidase M48B family
CH58_3188	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH58_319	COG4238	major outer membrane lipoprotein
CH58_3190	COG1943	Transposase
CH58_3193	COG0191	fructose-bisphosphate aldolase activity
CH58_32	COG2951	lytic endotransglycosylase activity
CH58_320	COG1943	Transposase
CH58_3200	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH58_3201	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH58_3202	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH58_3205	COG0006	proline dipeptidase activity
CH58_3206	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH58_3207	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH58_3213	COG5295	Hep Hag repeat protein
CH58_3215	COG1272	protein, Hemolysin III
CH58_3218	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CH58_3219	COG0745	RESPONSE REGULATOR receiver
CH58_3220	COG2205	protein histidine kinase activity
CH58_3221	COG4452	Inner membrane protein CreD
CH58_3222	COG0716	FMN binding
CH58_3223	COG4974	Belongs to the 'phage' integrase family
CH58_3224	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH58_3225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH58_3229	COG0582	viral genome integration into host DNA
CH58_323	COG1376	ErfK ybiS ycfS ynhG family protein
CH58_323	COG1388	LysM domain
CH58_3232	COG0582	viral genome integration into host DNA
CH58_3237	COG2944	sequence-specific DNA binding
CH58_3254	COG1695	Transcriptional regulator
CH58_3255	COG0791	NLP P60 protein
CH58_3257	COG1879	ABC-type sugar transport system periplasmic component
CH58_3258	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_3259	COG1129	ABC transporter
CH58_326	COG0719	Fe-S assembly protein
CH58_3261	COG2182	Extracellular solute-binding protein
CH58_3262	COG1175	transmembrane transport
CH58_3263	COG3833	ABC-type maltose transport systems, permease component
CH58_3264	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CH58_3265	COG1874	Beta-galactosidase
CH58_3266	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH58_3266	COG1263	PTS System
CH58_327	COG0396	ATPase activity
CH58_3270	COG2271	Major facilitator Superfamily
CH58_3274	COG0191	fructose-bisphosphate aldolase activity
CH58_3276	COG3119	arylsulfatase activity
CH58_3277	COG0641	radical SAM
CH58_3279	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_328	COG0719	Fe-S assembly protein
CH58_3281	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH58_3282	COG3716	PTS system mannose fructose sorbose family IID component
CH58_3283	COG3715	PTS system
CH58_3284	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH58_3285	COG2222	sugar isomerase
CH58_3287	COG1349	DNA-binding transcription factor activity
CH58_3288	COG3119	arylsulfatase activity
CH58_3289	COG1943	Transposase
CH58_329	COG0316	Belongs to the HesB IscA family
CH58_3296	COG0288	reversible hydration of carbon dioxide
CH58_33	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH58_330	COG2050	protein possibly involved in aromatic compounds catabolism
CH58_331	COG0247	lactate metabolic process
CH58_331	COG0277	FAD linked oxidase domain protein
CH58_3316	COG0840	transmembrane signaling receptor activity
CH58_3318	COG0583	DNA-binding transcription factor activity
CH58_3319	COG0583	DNA-binding transcription factor activity
CH58_332	COG0628	permease
CH58_3320	COG2814	Major facilitator Superfamily
CH58_3321	COG1609	Transcriptional regulator
CH58_3322	COG0019	diaminopimelate decarboxylase activity
CH58_3328	COG0667	Aldo Keto reductase
CH58_333	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH58_333	COG0574	Belongs to the PEP-utilizing enzyme family
CH58_3339	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH58_3341	COG1074	ATP-dependent DNA helicase activity
CH58_3342	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH58_3344	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH58_3347	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH58_3348	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH58_3349	COG2166	iron-sulfur cluster assembly
CH58_3350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH58_3352	COG0583	DNA-binding transcription factor activity
CH58_3353	COG2363	Small membrane protein
CH58_3359	COG1611	Belongs to the LOG family
CH58_3362	COG1943	Transposase
CH58_3363	COG3098	single-species biofilm formation
CH58_3364	COG0564	pseudouridine synthase activity
CH58_3369	COG0024	Methionine aminopeptidase
CH58_3373	COG1943	Transposase
CH58_3377	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CH58_3378	COG0575	Belongs to the CDS family
CH58_3379	COG0750	zinc metalloprotease
CH58_3381	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH58_3385	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH58_3387	COG0587	DNA-directed DNA polymerase activity
CH58_3389	COG0346	lactoylglutathione lyase activity
CH58_339	COG0791	NLP P60 protein
CH58_3390	COG0037	tRNA processing
CH58_3392	COG4568	rho-dependent transcription termination
CH58_3394	COG4681	YaeQ
CH58_3396	COG3015	lipoprotein NlpE involved in copper resistance
CH58_3398	COG1720	tRNA m6t6A37 methyltransferase activity
CH58_3400	COG1464	Belongs to the NlpA lipoprotein family
CH58_3401	COG2011	ABC-type metal ion transport system permease component
CH58_3403	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH58_3409	COG0656	L-ascorbic acid biosynthetic process
CH58_3412	COG1388	LysM domain
CH58_3412	COG0741	lytic transglycosylase activity
CH58_3414	COG2226	methyltransferase
CH58_3416	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH58_3418	COG1953	Uracil, thiamine, allantoin
CH58_3425	COG3657	addiction module killer protein
CH58_3435	COG0582	viral genome integration into host DNA
CH58_3436	COG1943	Transposase
CH58_3438	COG2867	negative regulation of translational initiation
CH58_3440	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH58_3441	COG0497	DNA recombination
CH58_3442	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH58_3445	COG2009	succinate dehydrogenase
CH58_3446	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH58_3447	COG1053	succinate dehydrogenase
CH58_3449	COG0567	Dehydrogenase, E1 component
CH58_3450	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH58_3452	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH58_3453	COG1271	oxidase subunit
CH58_3454	COG1294	oxidase, subunit
CH58_3455	COG4890	Cyd operon protein YbgT
CH58_3456	COG3790	cyd operon protein YbgE
CH58_3457	COG0824	Thioesterase
CH58_3458	COG0811	peptide transport
CH58_3459	COG0848	biopolymer transport protein
CH58_3460	COG3064	Membrane
CH58_3460	COG3064	Membrane
CH58_3462	COG2885	chlorophyll binding
CH58_3463	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH58_3469	COG1230	cation diffusion facilitator family transporter
CH58_347	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH58_3471	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH58_3474	COG1686	Belongs to the peptidase S11 family
CH58_3475	COG0814	amino acid
CH58_3476	COG1349	DNA-binding transcription factor activity
CH58_3477	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH58_3478	COG0671	phosphoesterase, PA-phosphatase related
CH58_348	COG0386	Belongs to the glutathione peroxidase family
CH58_3480	COG0569	domain protein
CH58_3480	COG2985	domain, Protein
CH58_3481	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH58_3484	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH58_3485	COG3842	ATPase activity
CH58_3486	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH58_3487	COG1177	transmembrane transport
CH58_3490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH58_3495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH58_3496	COG1120	ATPase activity
CH58_35	COG0582	viral genome integration into host DNA
CH58_3500	COG4160	amino acid transport
CH58_3501	COG4215	(ABC) transporter
CH58_3502	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH58_3503	COG1126	abc transporter atp-binding protein
CH58_3504	COG1605	Chorismate mutase
CH58_3506	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH58_3507	COG0702	epimerase
CH58_3508	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH58_3509	COG0028	Belongs to the TPP enzyme family
CH58_351	COG0776	regulation of translation
CH58_3510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH58_3512	COG2431	L-lysine efflux transmembrane transporter activity
CH58_3513	COG3593	DNA synthesis involved in DNA repair
CH58_3514	COG2990	Protein conserved in bacteria
CH58_3515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH58_3517	COG1278	Cold shock
CH58_3519	COG0542	response to heat
CH58_352	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH58_352	COG0072	phenylalanine-tRNA ligase activity
CH58_3520	COG1943	Transposase
CH58_3521	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH58_3523	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH58_3525	COG0492	ferredoxin-NADP+ reductase activity
CH58_3527	COG3107	peptidoglycan biosynthetic process
CH58_3527	COG1674	ftsk spoiiie
CH58_3530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH58_3534	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH58_3536	COG1882	Formate acetyltransferase
CH58_3537	COG2116	formate transmembrane transporter activity
CH58_3538	COG1944	ATP diphosphatase activity
CH58_3539	COG0252	asparaginase activity
CH58_3540	COG5295	Hep Hag repeat protein
CH58_3540	COG5295	Hep Hag repeat protein
CH58_3545	COG0539	negative regulation of cytoplasmic translation
CH58_3548	COG2333	competence protein COMEC
CH58_3548	COG0658	competence protein
CH58_3551	COG5383	Protein conserved in bacteria
CH58_3554	COG5383	Protein conserved in bacteria
CH58_3555	COG1278	Cold shock
CH58_3556	COG2835	tetraacyldisaccharide 4'-kinase activity
CH58_3558	COG3173	Aminoglycoside phosphotransferase
CH58_3559	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH58_3560	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH58_3561	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CH58_3563	COG1943	Transposase
CH58_3564	COG2989	Protein conserved in bacteria
CH58_3565	COG3108	Peptidase M15
CH58_3566	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH58_3567	COG1448	Aminotransferase
CH58_3571	COG0308	aminopeptidase N
CH58_3574	COG0633	Ferredoxin
CH58_3574	COG3217	Mosc domain protein beta barrel domain protein
CH58_3576	COG0488	(ABC) transporter
CH58_3577	COG2995	paraquat-inducible protein a
CH58_3578	COG3008	intermembrane lipid transfer
CH58_3578	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH58_3579	COG3009	Protein conserved in bacteria
CH58_358	COG4249	Peptidase C14 caspase catalytic subunit p20
CH58_3580	COG1943	Transposase
CH58_3581	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH58_3585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH58_3588	COG1067	ATP-dependent peptidase activity
CH58_3590	COG1943	Transposase
CH58_3591	COG2885	chlorophyll binding
CH58_3591	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH58_3593	COG3070	regulator of competence-specific genes
CH58_3594	COG1289	transmembrane transporter activity
CH58_3595	COG3304	Inner membrane component domain
CH58_3596	COG0210	DNA helicase
CH58_3598	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CH58_3599	COG1832	CoA-binding protein
CH58_3603	COG2920	part of a sulfur-relay system
CH58_3610	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_3612	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH58_3613	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH58_3614	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_3615	COG3425	synthase
CH58_3617	COG1024	Enoyl-CoA hydratase
CH58_3618	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_362	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH58_3620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CH58_3621	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH58_363	COG1121	(ABC) transporter
CH58_364	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH58_365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH58_3653	COG0488	(ABC) transporter
CH58_3655	COG3328	transposase activity
CH58_3657	COG0303	'Molybdopterin
CH58_3659	COG1136	(ABC) transporter
CH58_3665	COG0583	DNA-binding transcription factor activity
CH58_3666	COG0477	Major facilitator Superfamily
CH58_3668	COG2311	Membrane
CH58_3671	COG4211	Belongs to the binding-protein-dependent transport system permease family
CH58_3672	COG2949	membrane
CH58_3675	COG1346	cytolysis
CH58_3677	COG2814	Major facilitator Superfamily
CH58_368	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH58_3681	COG1943	Transposase
CH58_3683	COG0489	protein tyrosine kinase activity
CH58_3686	COG2982	Protein involved in outer membrane biogenesis
CH58_3687	COG1253	flavin adenine dinucleotide binding
CH58_3688	COG4114	ferric iron reductase
CH58_3689	COG0076	glutamate decarboxylase activity
CH58_369	COG3328	transposase activity
CH58_3690	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CH58_3693	COG1120	ATPase activity
CH58_3694	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH58_3695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH58_3696	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH58_370	COG3328	transposase activity
CH58_3700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH58_3701	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH58_3703	COG0140	phosphoribosyl-ATP diphosphatase activity
CH58_3703	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH58_3706	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CH58_3707	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH58_3707	COG0131	Imidazoleglycerol-phosphate dehydratase
CH58_3709	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CH58_371	COG1917	Cupin 2, conserved barrel domain protein
CH58_3711	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH58_3713	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_3714	COG1129	ABC transporter
CH58_3715	COG1129	ABC transporter
CH58_3716	COG0371	Dehydrogenase
CH58_3718	COG0531	amino acid
CH58_3719	COG2925	Exonuclease
CH58_3722	COG1388	LysM domain
CH58_3722	COG1470	cell adhesion involved in biofilm formation
CH58_3723	COG3328	transposase activity
CH58_3724	COG2271	Major facilitator Superfamily
CH58_3725	COG3011	Protein conserved in bacteria
CH58_3726	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_3728	COG4948	Mandelate Racemase Muconate Lactonizing
CH58_373	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_3732	COG0534	Mate efflux family protein
CH58_3736	COG3122	Protein conserved in bacteria
CH58_3741	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH58_3745	COG2223	nitrite transmembrane transporter activity
CH58_3746	COG3328	transposase activity
CH58_3747	COG3328	transposase activity
CH58_3748	COG3328	transposase activity
CH58_3749	COG0513	Belongs to the DEAD box helicase family
CH58_3750	COG1943	Transposase
CH58_3752	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH58_3754	COG1686	Belongs to the peptidase S11 family
CH58_3755	COG0277	FAD linked oxidase domain protein
CH58_3757	COG1403	HNH endonuclease
CH58_3759	COG2261	transglycosylase associated protein
CH58_3761	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CH58_3764	COG4807	Protein conserved in bacteria
CH58_3768	COG1122	ATPase activity
CH58_3769	COG0410	ABC transporter
CH58_3772	COG2897	thiosulfate sulfurtransferase activity
CH58_3775	COG1174	glycine betaine transport
CH58_3776	COG1125	glycine betaine transport
CH58_3777	COG1174	glycine betaine transport
CH58_3778	COG0531	amino acid
CH58_3779	COG1982	Orn Lys Arg decarboxylase major
CH58_3781	COG0697	spore germination
CH58_379	COG1175	transmembrane transport
CH58_3790	COG0814	amino acid
CH58_3793	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH58_3798	COG2205	protein histidine kinase activity
CH58_3798	COG0784	Response regulator, receiver
CH58_380	COG0395	ABC-type sugar transport system, permease component
CH58_3800	COG2198	Histidine kinase
CH58_3800	COG0642	Histidine kinase
CH58_3801	COG2198	Histidine kinase
CH58_3801	COG0642	Histidine kinase
CH58_3802	COG2223	nitrite transmembrane transporter activity
CH58_3804	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH58_3807	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH58_381	COG3842	ATPase activity
CH58_3815	COG3395	kinase activity
CH58_3816	COG0235	Class ii aldolase
CH58_3817	COG1349	DNA-binding transcription factor activity
CH58_3818	COG3622	Belongs to the hyi family
CH58_382	COG1653	transport
CH58_3822	COG4386	tail sheath protein
CH58_383	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH58_3831	COG3299	homolog of phage Mu protein gp47
CH58_3835	COG1737	Transcriptional regulator
CH58_3837	COG2723	6-phospho-beta-galactosidase activity
CH58_384	COG1988	membrane-bound metal-dependent
CH58_3841	COG3157	Type VI secretion system effector, Hcp
CH58_3845	COG3157	Type VI secretion system effector, Hcp
CH58_3848	COG3083	sulfuric ester hydrolase activity
CH58_3849	COG3082	Protein of unknown function (DUF1414)
CH58_3851	COG1943	Transposase
CH58_3853	COG1061	Type III restriction enzyme res subunit
CH58_3854	COG1187	pseudouridine synthase activity
CH58_3855	COG2814	Major facilitator Superfamily
CH58_3857	COG4172	Belongs to the ABC transporter superfamily
CH58_3858	COG4239	(ABC) transporter, permease
CH58_3859	COG4174	ABC transporter (Permease)
CH58_386	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH58_3860	COG4166	transmembrane transport
CH58_3861	COG2200	EAL domain
CH58_3863	COG0791	NLP P60 protein
CH58_3864	COG0671	phosphoesterase, PA-phosphatase related
CH58_3865	COG0523	cobalamin synthesis protein
CH58_3867	COG2186	Transcriptional regulator
CH58_3868	COG0246	Mannitol dehydrogenase
CH58_3873	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_3876	COG2801	Transposase and inactivated derivatives
CH58_388	COG0823	Involved in the tonB-independent uptake of proteins
CH58_3880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH58_3882	COG1129	ABC transporter
CH58_3883	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_3884	COG0494	nUDIX hydrolase
CH58_3886	COG1105	Belongs to the carbohydrate kinase PfkB family
CH58_3887	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH58_3887	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH58_3887	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH58_3888	COG3710	Transcriptional regulator
CH58_389	COG2814	Major facilitator Superfamily
CH58_3891	COG3121	Chaperone
CH58_3892	COG3188	usher protein
CH58_3894	COG2855	membrane
CH58_3895	COG0583	DNA-binding transcription factor activity
CH58_3897	COG0833	amino acid
CH58_3899	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH58_390	COG3121	Chaperone
CH58_3901	COG4771	TonB-dependent receptor
CH58_3902	COG0625	glutathione transferase activity
CH58_3908	COG2011	ABC-type metal ion transport system permease component
CH58_3909	COG1686	Belongs to the peptidase S11 family
CH58_3915	COG2017	converts alpha-aldose to the beta-anomer
CH58_3918	COG1085	galactose-1-phosphate uridylyltransferase
CH58_3919	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH58_3922	COG1119	ATPase activity
CH58_3923	COG2005	Transcriptional regulator
CH58_3923	COG3585	molybdate ion transport
CH58_3925	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH58_3926	COG4149	molybdate abc transporter
CH58_3928	COG0561	phosphatase activity
CH58_3933	COG2226	methyltransferase
CH58_3934	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH58_3937	COG4628	conserved protein (DUF2132)
CH58_3938	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH58_394	COG3121	Chaperone
CH58_3940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH58_3942	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH58_3943	COG0314	molybdopterin synthase activity
CH58_3944	COG0670	Belongs to the BI1 family
CH58_3945	COG1943	Transposase
CH58_3949	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CH58_395	COG3539	Fimbrial protein
CH58_3950	COG0583	DNA-binding transcription factor activity
CH58_3952	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CH58_3953	COG2211	Major facilitator Superfamily
CH58_3954	COG1943	Transposase
CH58_3955	COG2211	Major facilitator Superfamily
CH58_3960	COG1902	pentaerythritol trinitrate reductase activity
CH58_3962	COG0842	Transport permease protein
CH58_3963	COG0842	Transport permease protein
CH58_3964	COG1131	(ABC) transporter
CH58_3966	COG1309	transcriptional regulator
CH58_3967	COG0513	Belongs to the DEAD box helicase family
CH58_3974	COG3328	transposase activity
CH58_398	COG0793	Belongs to the peptidase S41A family
CH58_3984	COG1132	(ABC) transporter
CH58_3986	COG2207	Transcriptional regulator
CH58_3993	COG1113	amino acid transport
CH58_3995	COG1278	Cold shock
CH58_3997	COG2226	methyltransferase
CH58_3999	COG5001	Diguanylate cyclase
CH58_3999	COG5002	protein histidine kinase activity
CH58_3999	COG3447	MASE1 domain protein
CH58_4	COG0494	nUDIX hydrolase
CH58_400	COG1956	GAF domain-containing protein
CH58_4003	COG3716	PTS system mannose fructose sorbose family IID component
CH58_4004	COG3715	PTS system
CH58_4005	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH58_4005	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH58_4006	COG1253	flavin adenine dinucleotide binding
CH58_4007	COG1846	Transcriptional regulator
CH58_401	COG2995	paraquat-inducible protein a
CH58_4010	COG1012	belongs to the aldehyde dehydrogenase family
CH58_4011	COG3384	dioxygenase
CH58_4013	COG3971	2-oxopent-4-enoate hydratase activity
CH58_4016	COG2368	4-hydroxyphenylacetate
CH58_4018	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CH58_4019	COG1760	l-serine dehydratase
CH58_402	COG3008	intermembrane lipid transfer
CH58_4024	COG0513	Belongs to the DEAD box helicase family
CH58_4025	COG3141	response to X-ray
CH58_4028	COG1770	oligopeptidase
CH58_4034	COG1528	Iron-storage protein
CH58_4035	COG2372	response to copper ion
CH58_4040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH58_4041	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH58_4044	COG1943	Transposase
CH58_4046	COG3418	PFAM FlgN family protein
CH58_4047	COG2747	anti-sigma28 factor FlgM
CH58_4049	COG1815	bacterial-type flagellum-dependent cell motility
CH58_4050	COG1558	bacterial-type flagellum-dependent cell motility
CH58_4051	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH58_4052	COG1749	Flagellar hook protein flgE
CH58_4054	COG4786	Flagellar basal body rod
CH58_4058	COG1256	bacterial-type flagellum assembly
CH58_406	COG3121	Chaperone
CH58_4060	COG2390	Transcriptional regulator
CH58_4061	COG3347	Dehydrogenase
CH58_4061	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_4062	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_4064	COG1129	ABC transporter
CH58_4067	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH58_4071	COG1987	bacterial-type flagellum assembly
CH58_4076	COG1580	Controls the rotational direction of flagella during chemotaxis
CH58_4078	COG2882	bacterial-type flagellum organization
CH58_4079	COG1157	protein secretion by the type III secretion system
CH58_4081	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH58_4083	COG1677	Flagellar hook-basal body complex protein FliE
CH58_4086	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CH58_4087	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH58_4088	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CH58_4094	COG1191	sigma factor activity
CH58_4096	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH58_4106	COG0506	proline dehydrogenase activity
CH58_4106	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH58_4106	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH58_4111	COG2837	iron assimilation
CH58_4114	COG1113	amino acid transport
CH58_4118	COG3136	membrane protein required for alginate biosynthesis
CH58_4120	COG2197	response regulator
CH58_4143	COG3328	transposase activity
CH58_4144	COG3328	transposase activity
CH58_4151	COG0673	inositol 2-dehydrogenase activity
CH58_4153	COG1175	transmembrane transport
CH58_4154	COG0395	ABC-type sugar transport system, permease component
CH58_4168	COG4771	TonB-dependent receptor
CH58_4169	COG1021	2,3-dihydroxybenzoate-AMP ligase
CH58_4173	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH58_4173	COG3433	isochorismatase activity
CH58_4173	COG2226	methyltransferase
CH58_4176	COG1132	(ABC) transporter
CH58_4177	COG2814	Major facilitator Superfamily
CH58_4178	COG1169	isochorismate synthase
CH58_4179	COG0582	viral genome integration into host DNA
CH58_4181	COG3121	Chaperone
CH58_4183	COG3188	usher protein
CH58_4186	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH58_4186	COG2205	protein histidine kinase activity
CH58_4189	COG0427	acetyl-CoA hydrolase
CH58_419	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH58_4190	COG2030	dehydratase
CH58_4201	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH58_4202	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH58_4204	COG1349	DNA-binding transcription factor activity
CH58_4205	COG2066	Belongs to the glutaminase family
CH58_4207	COG0672	)-iron permease
CH58_4210	COG1136	(ABC) transporter
CH58_4210	COG0577	efflux transmembrane transporter activity
CH58_4212	COG1136	(ABC) transporter
CH58_4212	COG0577	efflux transmembrane transporter activity
CH58_4216	COG0006	proline dipeptidase activity
CH58_4217	COG0457	Tetratricopeptide repeat
CH58_4218	COG1649	PFAM Uncharacterised BCR, COG1649
CH58_4218	COG0726	polysaccharide deacetylase
CH58_4219	COG1215	transferase activity, transferring glycosyl groups
CH58_422	COG5295	Hep Hag repeat protein
CH58_4220	COG3658	cytochrome
CH58_4223	COG1702	phosphate starvation-inducible protein PhoH
CH58_4224	COG0387	Pfam Sodium calcium exchanger
CH58_4225	COG3850	Histidine kinase
CH58_4226	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH58_424	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH58_4240	COG0402	S-adenosylhomocysteine deaminase activity
CH58_4243	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CH58_4244	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CH58_4245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH58_425	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH58_4254	COG3328	transposase activity
CH58_4259	COG0500	methyltransferase
CH58_426	COG0745	RESPONSE REGULATOR receiver
CH58_4268	COG5002	protein histidine kinase activity
CH58_4279	COG0012	GTP binding
CH58_428	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH58_4282	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH58_4287	COG2890	protein-(glutamine-N5) methyltransferase activity
CH58_4288	COG3094	Invasion gene expression up-regulator, SirB
CH58_4289	COG2912	Transglutaminase-like superfamily
CH58_429	COG0840	transmembrane signaling receptor activity
CH58_4291	COG0659	secondary active sulfate transmembrane transporter activity
CH58_4294	COG0659	secondary active sulfate transmembrane transporter activity
CH58_4298	COG3833	ABC-type maltose transport systems, permease component
CH58_4299	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH58_430	COG0840	transmembrane signaling receptor activity
CH58_4301	COG1943	Transposase
CH58_4302	COG3842	ATPase activity
CH58_4303	COG0584	glycerophosphoryl diester phosphodiesterase
CH58_4304	COG1940	carbohydrate kinase activity
CH58_4307	COG3381	protein complex oligomerization
CH58_4310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH58_4311	COG0673	inositol 2-dehydrogenase activity
CH58_4312	COG0728	peptidoglycan biosynthetic process
CH58_4316	COG3102	Protein conserved in bacteria
CH58_4336	COG3328	transposase activity
CH58_4338	COG3344	reverse transcriptase
CH58_434	COG2964	Protein conserved in bacteria
CH58_4340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH58_4357	COG1475	DNA binding
CH58_436	COG0251	oxidation-reduction process
CH58_4360	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CH58_4362	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH58_4362	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH58_437	COG2271	Major facilitator Superfamily
CH58_4370	COG3941	tape measure
CH58_438	COG0835	chemotaxis
CH58_4389	COG1475	DNA binding
CH58_439	COG2198	Histidine kinase
CH58_439	COG0643	Histidine kinase
CH58_4390	COG1475	DNA binding
CH58_4391	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH58_4397	COG1943	Transposase
CH58_440	COG1360	Flagellar Motor Protein
CH58_4416	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH58_4418	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH58_4432	COG4669	(LipO)protein
CH58_4434	COG1317	bacterial-type flagellum organization
CH58_4435	COG5599	Phosphatase
CH58_4436	COG2963	transposase activity
CH58_4440	COG2801	Transposase and inactivated derivatives
CH58_4443	COG2801	Transposase and inactivated derivatives
CH58_4445	COG0515	serine threonine protein kinase
CH58_445	COG1285	pathogenesis
CH58_446	COG0840	transmembrane signaling receptor activity
CH58_4463	COG2801	Transposase and inactivated derivatives
CH58_4468	COG2801	Transposase and inactivated derivatives
CH58_447	COG0840	transmembrane signaling receptor activity
CH58_4472	COG2801	Transposase and inactivated derivatives
CH58_4474	COG5599	Phosphatase
CH58_4476	COG3609	addiction module antidote protein, CC2985 family
CH58_4478	COG1475	DNA binding
CH58_4479	COG1192	Involved in chromosome partitioning
CH58_4481	COG2801	Transposase and inactivated derivatives
CH58_4485	COG3177	Filamentation induced by cAMP protein fic
CH58_449	COG1278	Cold shock
CH58_4490	COG4886	Leucine-rich repeat (LRR) protein
CH58_4493	COG0457	Tetratricopeptide repeat
CH58_4497	COG4789	Type iii secretion
CH58_4506	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH58_4507	COG4790	Type iii secretion
CH58_4508	COG4794	Type iii secretion
CH58_4509	COG4791	protein targeting
CH58_4510	COG4792	protein secretion
CH58_4513	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CH58_454	COG3321	synthase
CH58_454	COG0604	alcohol dehydrogenase
CH58_454	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_456	COG1522	sequence-specific DNA binding
CH58_461	COG1733	regulation of RNA biosynthetic process
CH58_462	COG0702	epimerase
CH58_463	COG0840	transmembrane signaling receptor activity
CH58_466	COG0538	isocitrate dehydrogenase activity
CH58_467	COG1187	pseudouridine synthase activity
CH58_471	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH58_473	COG0745	RESPONSE REGULATOR receiver
CH58_475	COG2850	peptidyl-arginine hydroxylation
CH58_477	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH58_479	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH58_481	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH58_482	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH58_483	COG3134	Outer membrane lipoprotein
CH58_484	COG3328	transposase activity
CH58_487	COG1252	NADH dehydrogenase
CH58_489	COG1472	Belongs to the glycosyl hydrolase 3 family
CH58_492	COG5633	Lipoprotein
CH58_493	COG0537	adenosine 5'-monophosphoramidase activity
CH58_494	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH58_497	COG1943	Transposase
CH58_498	COG1263	PTS System
CH58_498	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH58_499	COG0084	hydrolase, TatD family'
CH58_500	COG0470	DNA polymerase III
CH58_502	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH58_503	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH58_504	COG1943	Transposase
CH58_505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH58_507	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_51	COG1943	Transposase
CH58_511	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH58_512	COG1399	metal-binding, possibly nucleic acid-binding protein
CH58_514	COG1943	Transposase
CH58_515	COG0564	pseudouridine synthase activity
CH58_516	COG1530	ribonuclease E activity
CH58_519	COG3328	transposase activity
CH58_520	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH58_523	COG3328	transposase activity
CH58_525	COG3328	transposase activity
CH58_527	COG3328	transposase activity
CH58_529	COG0628	permease
CH58_534	COG2771	luxR family
CH58_535	COG3916	Acyl-homoserine-lactone synthase
CH58_536	COG0583	DNA-binding transcription factor activity
CH58_538	COG0477	Major facilitator Superfamily
CH58_540	COG0667	Aldo Keto reductase
CH58_545	COG1203	CRISPR-associated helicase, Cas3
CH58_546	COG1518	maintenance of DNA repeat elements
CH58_547	COG0668	transmembrane transport
CH58_551	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CH58_552	COG0395	ABC-type sugar transport system, permease component
CH58_555	COG1609	Transcriptional regulator
CH58_557	COG3842	ATPase activity
CH58_559	COG3210	domain, Protein
CH58_562	COG3210	domain, Protein
CH58_565	COG3210	domain, Protein
CH58_566	COG2831	hemolysin activation secretion protein
CH58_567	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH58_568	COG4638	Rieske (2fe-2S)
CH58_569	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CH58_570	COG0473	3-isopropylmalate dehydrogenase activity
CH58_571	COG0583	DNA-binding transcription factor activity
CH58_572	COG1609	Transcriptional regulator
CH58_573	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH58_574	COG1129	ABC transporter
CH58_575	COG1879	ABC-type sugar transport system periplasmic component
CH58_576	COG1063	alcohol dehydrogenase
CH58_582	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH58_583	COG0765	amino acid transport
CH58_584	COG1126	abc transporter atp-binding protein
CH58_590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH58_593	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH58_596	COG1169	isochorismate synthase
CH58_598	COG4575	ribosome binding
CH58_600	COG0129	dihydroxy-acid dehydratase activity
CH58_603	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH58_604	COG1609	Transcriptional regulator
CH58_606	COG1028	Short-chain dehydrogenase reductase Sdr
CH58_607	COG3265	gluconokinase activity
CH58_608	COG2731	YhcH YjgK YiaL family protein
CH58_611	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH58_612	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH58_614	COG0839	Belongs to the complex I subunit 6 family
CH58_617	COG1034	ATP synthesis coupled electron transport
CH58_619	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CH58_621	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH58_623	COG0583	DNA-binding transcription factor activity
CH58_624	COG0436	Aminotransferase
CH58_626	COG0471	metal ion transport
CH58_626	COG0490	domain, Protein
CH58_627	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH58_631	COG0857	belongs to the CobB CobQ family
CH58_631	COG0280	phosphate acetyltransferase
CH58_632	COG1609	Transcriptional regulator
CH58_635	COG3037	sugar-specific permease SgaT UlaA
CH58_636	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH58_637	COG0622	Phosphoesterase
CH58_640	COG1090	epimerase
CH58_641	COG4598	ABC transporter
CH58_642	COG4160	amino acid transport
CH58_643	COG4215	(ABC) transporter
CH58_644	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH58_647	COG0163	prenyltransferase activity
CH58_648	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH58_649	COG1286	toxin biosynthetic process
CH58_650	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH58_651	COG0285	dihydrofolate synthase activity
CH58_653	COG0586	Pfam SNARE associated Golgi protein
CH58_655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH58_658	COG0697	spore germination
CH58_661	COG1794	racemase activity, acting on amino acids and derivatives
CH58_662	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH58_665	COG3101	peptidyl-lysine hydroxylation
CH58_666	COG0730	response to heat
CH58_669	COG2890	protein-(glutamine-N5) methyltransferase activity
CH58_67	COG3328	transposase activity
CH58_671	COG2062	phosphohistidine phosphatase, SixA
CH58_674	COG3691	Protein conserved in bacteria
CH58_677	COG4235	cytochrome complex assembly
CH58_677	COG3088	subunit of a heme lyase
CH58_678	COG3088	subunit of a heme lyase
CH58_678	COG4235	cytochrome complex assembly
CH58_679	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH58_680	COG1138	Cytochrome C-type biogenesis protein
CH58_682	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH58_683	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH58_684	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH58_688	COG1704	LemA family
CH58_69	COG1104	cysteine desulfurase activity
CH58_690	COG2824	Alkylphosphonate utilization operon protein PhnA
CH58_696	COG3501	Rhs element vgr protein
CH58_7	COG1943	Transposase
CH58_709	COG3188	usher protein
CH58_711	COG3328	transposase activity
CH58_712	COG3188	usher protein
CH58_713	COG3121	Chaperone
CH58_725	COG2951	lytic endotransglycosylase activity
CH58_732	COG0243	molybdopterin cofactor binding
CH58_733	COG0437	4 iron, 4 sulfur cluster binding
CH58_734	COG3302	dmso reductase anchor subunit
CH58_735	COG3381	protein complex oligomerization
CH58_741	COG3038	cytochrome b561
CH58_742	COG0436	Aminotransferase
CH58_747	COG0667	Aldo Keto reductase
CH58_75	COG2719	SpoVR family
CH58_750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH58_755	COG1943	Transposase
CH58_759	COG3530	Putative quorum-sensing-regulated virulence factor
CH58_762	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CH58_763	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CH58_764	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH58_766	COG2190	(PTS) system
CH58_767	COG1943	Transposase
CH58_769	COG2205	protein histidine kinase activity
CH58_77	COG2814	Major facilitator Superfamily
CH58_770	COG0745	RESPONSE REGULATOR receiver
CH58_771	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH58_774	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH58_776	COG0006	proline dipeptidase activity
CH58_778	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH58_780	COG3850	Histidine kinase
CH58_780	COG5002	protein histidine kinase activity
CH58_781	COG0745	RESPONSE REGULATOR receiver
CH58_784	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CH58_785	COG4208	sulfate ABC transporter
CH58_786	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH58_787	COG4150	thiosulfate binding
CH58_789	COG1737	Transcriptional regulator
CH58_79	COG0583	DNA-binding transcription factor activity
CH58_790	COG2731	YhcH YjgK YiaL family protein
CH58_792	COG4886	Leucine-rich repeat (LRR) protein
CH58_794	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH58_795	COG2837	iron assimilation
CH58_797	COG3111	PFAM Bacterial OB fold (BOF) protein
CH58_810	COG3005	denitrification pathway
CH58_811	COG3043	anaerobic respiration
CH58_813	COG3062	negative regulation of establishment of protein localization
CH58_814	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH58_814	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH58_815	COG2197	response regulator
CH58_817	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH58_819	COG1988	membrane-bound metal-dependent
CH58_82	COG2766	serine protein kinase
CH58_820	COG0641	radical SAM
CH58_821	COG3119	arylsulfatase activity
CH58_822	COG3842	ATPase activity
CH58_823	COG1175	transmembrane transport
CH58_824	COG1840	ABC-type Fe3 transport system, periplasmic component
CH58_826	COG1393	Belongs to the ArsC family
CH58_828	COG1876	peptidase activity
CH58_83	COG3713	MltA-interacting MipA family protein
CH58_832	COG2321	neutral zinc metallopeptidase
CH58_834	COG1943	Transposase
CH58_835	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH58_837	COG2716	regulation of RNA biosynthetic process
CH58_838	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH58_841	COG0628	permease
CH58_842	COG4783	chaperone-mediated protein folding
CH58_843	COG1393	Belongs to the ArsC family
CH58_845	COG1943	Transposase
CH58_848	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH58_849	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH58_853	COG0581	inorganic phosphate transmembrane transporter activity
CH58_855	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH58_856	COG0248	Ppx GppA phosphatase
CH58_857	COG2239	Acts as a magnesium transporter
CH58_858	COG0443	Heat shock 70 kDa protein
CH58_861	COG1177	transmembrane transport
CH58_862	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH58_864	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CH58_866	COG3842	ATPase activity
CH58_87	COG3139	Protein of unknown function (DUF1315)
CH58_871	COG2205	protein histidine kinase activity
CH58_872	COG0745	RESPONSE REGULATOR receiver
CH58_873	COG3422	double-strand break repair
CH58_879	COG0351	phosphomethylpyrimidine kinase
CH58_88	COG1335	isochorismatase
CH58_882	COG3328	transposase activity
CH58_889	COG1943	Transposase
CH58_89	COG0252	asparaginase activity
CH58_891	COG0517	IMP dehydrogenase activity
CH58_891	COG0516	GMP reductase activity
CH58_893	COG1645	bacterial-type flagellum-dependent swarming motility
CH58_896	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH58_897	COG2976	Protein conserved in bacteria
CH58_90	COG0616	signal peptide processing
CH58_905	COG3468	outer membrane autotransporter barrel domain protein
CH58_906	COG3468	outer membrane autotransporter barrel domain protein
CH58_91	COG0778	Nitroreductase
CH58_910	COG2975	iron-sulfur cluster assembly
CH58_911	COG0633	Ferredoxin
CH58_912	COG0443	Heat shock 70 kDa protein
CH58_915	COG0822	iron-sulfur transferase activity
CH58_916	COG1104	cysteine desulfurase activity
CH58_919	COG0483	inositol monophosphate 1-phosphatase activity
CH58_92	COG0709	Synthesizes selenophosphate from selenide and ATP
CH58_920	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH58_921	COG3683	transport system, periplasmic component
CH58_922	COG2814	Major facilitator Superfamily
CH58_923	COG3711	transcriptional antiterminator
CH58_926	COG1017	nitric oxide dioxygenase activity
CH58_926	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH58_929	COG0347	Belongs to the P(II) protein family
CH58_93	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH58_930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH58_930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH58_931	COG2204	response regulator
CH58_932	COG3170	Tfp pilus assembly protein FimV
CH58_933	COG2205	protein histidine kinase activity
CH58_934	COG1943	Transposase
CH58_940	COG0590	tRNA wobble adenosine to inosine editing
CH58_941	COG0560	Phosphoserine phosphatase
CH58_943	COG1737	Transcriptional regulator
CH58_944	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH58_945	COG1943	Transposase
CH58_947	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH58_95	COG0494	nUDIX hydrolase
CH58_951	COG2113	Glycine betaine
CH58_952	COG4176	ABC-type proline glycine betaine transport system permease component
CH58_953	COG4175	Glycine betaine
CH58_954	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH58_96	COG0708	Exodeoxyribonuclease III
CH58_960	COG3328	transposase activity
CH58_964	COG1278	Cold shock
CH58_965	COG0747	negative chemotaxis
CH58_967	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH58_968	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH58_969	COG1124	(ABC) transporter
CH58_97	COG0583	DNA-binding transcription factor activity
CH58_976	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH58_978	COG4413	Urea transporter
CH58_979	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH58_981	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH58_982	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH58_983	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH58_984	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH58_985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH58_986	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH58_987	COG1917	Cupin 2, conserved barrel domain protein
CH58_987	COG2169	Transcriptional regulator
CH58_991	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH58_992	COG0033	Phosphoglucomutase
CH58_996	COG0745	RESPONSE REGULATOR receiver
CH58_997	COG2205	protein histidine kinase activity