locus-tag	class	description
ISU55_00010	COG0592	DNA-directed DNA polymerase activity
ISU55_00020	COG0187	DNA topoisomerase II activity
ISU55_00025	COG0561	phosphatase activity
ISU55_00035	COG2423	ornithine cyclodeaminase activity
ISU55_00040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISU55_00050	COG5645	(Lipo)protein
ISU55_00070	COG3977	Valine--pyruvate aminotransferase
ISU55_00080	COG0366	Alpha amylase catalytic
ISU55_00095	COG2885	chlorophyll binding
ISU55_00105	COG2818	Glycosylase
ISU55_00130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU55_00130	COG2213	PTS system mannitol-specific
ISU55_00140	COG3722	fumarate hydratase activity
ISU55_00165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISU55_00180	COG0437	4 iron, 4 sulfur cluster binding
ISU55_00185	COG2864	formate dehydrogenase
ISU55_00200	COG3276	selenocysteine insertion sequence binding
ISU55_00305	COG3501	Rhs element vgr protein
ISU55_00350	COG3501	Rhs element vgr protein
ISU55_00360	COG3209	COG3209 Rhs family protein
ISU55_00380	COG0673	inositol 2-dehydrogenase activity
ISU55_00385	COG1917	Cupin 2, conserved barrel domain protein
ISU55_00385	COG2207	Transcriptional regulator
ISU55_00390	COG1869	D-ribose catabolic process
ISU55_00395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU55_00400	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISU55_00405	COG0431	NADPH-dependent FMN reductase
ISU55_00410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISU55_00420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU55_00435	COG3077	Addiction module antitoxin, RelB DinJ family
ISU55_00440	COG2252	PERMEase
ISU55_00445	COG0025	NhaP-type Na H and K H
ISU55_00455	COG1560	Kdo2-lipid A biosynthetic process
ISU55_00465	COG1129	ABC transporter
ISU55_00470	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_00480	COG1069	ribulokinase activity
ISU55_00490	COG0625	glutathione transferase activity
ISU55_00510	COG1278	Cold shock
ISU55_00515	COG1278	Cold shock
ISU55_00520	COG3133	Outer membrane lipoprotein
ISU55_00525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU55_00535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU55_00565	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISU55_00570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU55_00580	COG4145	pantothenate transmembrane transporter activity
ISU55_00585	COG3924	membrane
ISU55_00595	COG0439	Biotin carboxylase
ISU55_00600	COG0511	ligase activity, forming carbon-carbon bonds
ISU55_00615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISU55_00620	COG0604	alcohol dehydrogenase
ISU55_00625	COG2200	EAL domain
ISU55_00625	COG2199	diguanylate cyclase activity
ISU55_00630	COG1077	Cell shape determining protein MreB Mrl
ISU55_00635	COG1792	Involved in formation and maintenance of cell shape
ISU55_00640	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISU55_00645	COG0424	maF-like protein
ISU55_00650	COG1530	ribonuclease E activity
ISU55_00655	COG3164	Protein of unknown function
ISU55_00660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU55_00665	COG0312	modulator of DNA gyrase
ISU55_00725	COG0583	DNA-binding transcription factor activity
ISU55_00755	COG2732	(Barnase) inhibitor
ISU55_00765	COG0312	modulator of DNA gyrase
ISU55_00775	COG3783	Cytochrome b(562)
ISU55_00780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU55_00785	COG0366	Alpha amylase catalytic
ISU55_00790	COG1263	PTS System
ISU55_00790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU55_00795	COG1609	Transcriptional regulator
ISU55_00820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU55_00840	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISU55_00845	COG1137	ATPase activity
ISU55_00850	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISU55_00855	COG3117	lipopolysaccharide transmembrane transporter activity
ISU55_00860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISU55_00865	COG0517	IMP dehydrogenase activity
ISU55_00865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISU55_00870	COG0530	calcium, potassium:sodium antiporter activity
ISU55_00875	COG1127	ABC transporter
ISU55_00880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISU55_00885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU55_00890	COG2854	intermembrane phospholipid transfer
ISU55_00895	COG3113	response to antibiotic
ISU55_00900	COG5007	Belongs to the BolA IbaG family
ISU55_00910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU55_00920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU55_00925	COG3105	Protein conserved in bacteria
ISU55_00930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISU55_00950	COG0625	glutathione transferase activity
ISU55_00955	COG2969	positive regulation of protein catabolic process
ISU55_00965	COG0493	'glutamate synthase
ISU55_00970	COG0070	glutamate synthase
ISU55_00970	COG0067	glutamate synthase
ISU55_00970	COG0069	glutamate synthase activity
ISU55_00975	COG1242	4 iron, 4 sulfur cluster binding
ISU55_00980	COG5002	protein histidine kinase activity
ISU55_00980	COG2198	Histidine kinase
ISU55_00980	COG0784	Response regulator, receiver
ISU55_00985	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISU55_00995	COG2823	Periplasmic or secreted lipoprotein
ISU55_01015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISU55_01025	COG1741	Belongs to the pirin family
ISU55_01030	COG0583	DNA-binding transcription factor activity
ISU55_01080	COG1879	ABC-type sugar transport system periplasmic component
ISU55_01085	COG1129	ABC transporter
ISU55_01090	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_01095	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_01105	COG3085	chromosome segregation
ISU55_01125	COG3978	acetolactate synthase activity
ISU55_01130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU55_01175	COG0583	DNA-binding transcription factor activity
ISU55_01210	COG3121	Chaperone
ISU55_01225	COG3121	Chaperone
ISU55_01235	COG3328	transposase activity
ISU55_01245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU55_01270	COG3118	belongs to the thioredoxin family
ISU55_01275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISU55_01280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISU55_01285	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU55_01290	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISU55_01295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISU55_01300	COG1088	dTDP-glucose 4,6-dehydratase activity
ISU55_01305	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISU55_01310	COG0456	acetyltransferase
ISU55_01315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISU55_01320	COG2244	polysaccharide biosynthetic process
ISU55_01340	COG1113	amino acid transport
ISU55_01370	COG3071	HemY protein
ISU55_01375	COG2959	enzyme of heme biosynthesis
ISU55_01380	COG1587	Uroporphyrinogen-III synthase
ISU55_01395	COG3072	Adenylate cyclase
ISU55_01415	COG3159	Protein conserved in bacteria
ISU55_01420	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ISU55_01425	COG1011	Hydrolase
ISU55_01430	COG0210	DNA helicase
ISU55_01440	COG5441	Belongs to the UPF0261 family
ISU55_01445	COG5564	TIM-barrel signal transduction protein
ISU55_01460	COG2050	protein possibly involved in aromatic compounds catabolism
ISU55_01465	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ISU55_01470	COG0514	ATP-dependent DNA helicase (RecQ)
ISU55_01475	COG1280	lysine exporter protein (LysE YggA)
ISU55_01480	COG1280	lysine exporter protein (LysE YggA)
ISU55_01485	COG2267	carboxylic ester hydrolase activity
ISU55_01490	COG0561	phosphatase activity
ISU55_01500	COG0584	glycerophosphoryl diester phosphodiesterase
ISU55_01505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU55_01515	COG0247	lactate metabolic process
ISU55_01525	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISU55_01540	COG3714	YhhN family
ISU55_01555	COG3776	membrane
ISU55_01560	COG0742	ribosomal rna small subunit methyltransferase
ISU55_01565	COG0552	protein localization to endoplasmic reticulum
ISU55_01565	COG0552	protein localization to endoplasmic reticulum
ISU55_01570	COG2884	Cell division ATP-binding protein ftsE
ISU55_01575	COG2177	Part of the ABC transporter FtsEX involved in
ISU55_01595	COG0683	leucine binding
ISU55_01605	COG4177	L-phenylalanine transmembrane transporter activity
ISU55_01615	COG0410	ABC transporter
ISU55_01675	COG0584	glycerophosphoryl diester phosphodiesterase
ISU55_01680	COG0679	Auxin Efflux Carrier
ISU55_01685	COG0697	spore germination
ISU55_01690	COG0583	DNA-binding transcription factor activity
ISU55_01700	COG0412	Dienelactone hydrolase
ISU55_01715	COG1966	Carbon starvation protein
ISU55_01720	COG0586	Pfam SNARE associated Golgi protein
ISU55_01725	COG1322	Protein conserved in bacteria
ISU55_01745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU55_01755	COG0805	protein transport
ISU55_01790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISU55_01830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISU55_01835	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISU55_01865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISU55_01925	COG0250	Participates in transcription elongation, termination and antitermination
ISU55_01980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISU55_02015	COG1515	deoxyribonuclease V activity
ISU55_02035	COG0151	Belongs to the GarS family
ISU55_02095	COG3162	membrane
ISU55_02105	COG1301	dicarboxylic acid transport
ISU55_02215	COG2391	methyltransferase activity
ISU55_02220	COG0425	Belongs to the sulfur carrier protein TusA family
ISU55_02225	COG0583	DNA-binding transcription factor activity
ISU55_02230	COG0814	amino acid
ISU55_02235	COG0626	cystathionine gamma-synthase activity
ISU55_02245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU55_02250	COG4558	Periplasmic binding protein
ISU55_02255	COG3720	iron ion transport
ISU55_02260	COG4771	TonB-dependent receptor
ISU55_02270	COG0702	epimerase
ISU55_02275	COG3721	Heme iron utilization protein
ISU55_02300	COG1358	cellular component organization or biogenesis
ISU55_02360	COG3121	Chaperone
ISU55_02400	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISU55_02410	COG0735	belongs to the Fur family
ISU55_02415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU55_02440	COG1448	Aminotransferase
ISU55_02445	COG2315	Protein conserved in bacteria
ISU55_02450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISU55_02455	COG0629	single-stranded DNA binding
ISU55_02465	COG1454	alcohol dehydrogenase
ISU55_02525	COG1309	transcriptional regulator
ISU55_02530	COG0493	'glutamate synthase
ISU55_02530	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU55_02535	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU55_02540	COG3383	formate dehydrogenase (NAD+) activity
ISU55_02555	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISU55_02600	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ISU55_02610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISU55_02615	COG1053	succinate dehydrogenase
ISU55_02630	COG1511	domain protein
ISU55_02630	COG3264	Mechanosensitive ion channel
ISU55_02645	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISU55_02660	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISU55_02665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISU55_02665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISU55_02670	COG0802	atpase or kinase
ISU55_02675	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU55_02695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISU55_02700	COG0330	HflC and HflK could
ISU55_02705	COG0330	HflC and HflK could
ISU55_02710	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISU55_02725	COG0557	exoribonuclease II activity
ISU55_02730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU55_02735	COG1960	acyl-CoA dehydrogenase activity
ISU55_02740	COG3650	response to hydrogen peroxide
ISU55_02760	COG1073	alpha beta
ISU55_02765	COG0360	Binds together with S18 to 16S ribosomal RNA
ISU55_02775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISU55_02795	COG3061	Opacity-associated protein A
ISU55_02800	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU55_02810	COG0737	Belongs to the 5'-nucleotidase family
ISU55_02820	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISU55_02830	COG1253	flavin adenine dinucleotide binding
ISU55_02840	COG0729	surface antigen
ISU55_02845	COG2911	Protein conserved in bacteria
ISU55_02850	COG2105	PFAM AIG2 family protein
ISU55_02855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISU55_02860	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ISU55_02865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISU55_02885	COG3423	Transcriptional regulator
ISU55_02895	COG0142	geranyltranstransferase activity
ISU55_02910	COG0697	spore germination
ISU55_02920	COG0642	Histidine kinase
ISU55_02925	COG0745	RESPONSE REGULATOR receiver
ISU55_02930	COG2027	D-alanyl-D-alanine carboxypeptidase
ISU55_02940	COG1534	Rna-binding protein
ISU55_02955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISU55_02965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISU55_02985	COG0195	Participates in both transcription termination and antitermination
ISU55_03030	COG0513	Belongs to the DEAD box helicase family
ISU55_03050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISU55_03060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU55_03070	COG0826	peptidase U32
ISU55_03075	COG0826	peptidase U32
ISU55_03080	COG3154	lipid carrier protein
ISU55_03085	COG3153	acetyltransferase
ISU55_03105	COG1653	transport
ISU55_03110	COG1175	transmembrane transport
ISU55_03115	COG0395	ABC-type sugar transport system, permease component
ISU55_03120	COG3842	ATPase activity
ISU55_03135	COG0702	epimerase
ISU55_03140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISU55_03145	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ISU55_03150	COG3454	Phosphonate metabolism
ISU55_03155	COG4778	phosphonate C-P lyase system protein PhnL
ISU55_03160	COG4107	phosphonate C-P lyase system protein PhnK
ISU55_03165	COG3627	carbon phosphorus lyase activity
ISU55_03170	COG3626	phosphonate metabolism
ISU55_03175	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISU55_03180	COG3624	Phosphonate C-P lyase system protein PhnG
ISU55_03185	COG2188	Transcriptional regulator
ISU55_03200	COG4608	Belongs to the ABC transporter superfamily
ISU55_03205	COG0444	Belongs to the ABC transporter superfamily
ISU55_03210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU55_03215	COG0601	transmembrane transport
ISU55_03225	COG2731	YhcH YjgK YiaL family protein
ISU55_03235	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ISU55_03245	COG0525	valine-tRNA ligase activity
ISU55_03250	COG2927	DNA polymerase III (CHI subunit)
ISU55_03260	COG0795	lipopolysaccharide-transporting ATPase activity
ISU55_03265	COG0795	lipopolysaccharide-transporting ATPase activity
ISU55_03275	COG0582	viral genome integration into host DNA
ISU55_03325	COG1459	type II secretion system
ISU55_03330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU55_03335	COG4969	Belongs to the N-Me-Phe pilin family
ISU55_03345	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU55_03350	COG3725	Membrane protein required for beta-lactamase induction
ISU55_03355	COG1113	amino acid transport
ISU55_03360	COG2186	Transcriptional regulator
ISU55_03365	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISU55_03370	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU55_03375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU55_03385	COG1049	propionate catabolic process, 2-methylcitrate cycle
ISU55_03395	COG0697	spore germination
ISU55_03415	COG2132	Multicopper oxidase
ISU55_03420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISU55_03425	COG0288	reversible hydration of carbon dioxide
ISU55_03430	COG1131	(ABC) transporter
ISU55_03435	COG0842	Transport permease protein
ISU55_03460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISU55_03465	COG0617	tRNA 3'-terminal CCA addition
ISU55_03470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISU55_03485	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISU55_03490	COG1643	Atp-dependent helicase
ISU55_03495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISU55_03500	COG1120	ATPase activity
ISU55_03505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU55_03510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU55_03530	COG2860	membrane
ISU55_03550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU55_03555	COG4999	Histidine kinase
ISU55_03555	COG3850	Histidine kinase
ISU55_03555	COG3437	response regulator, receiver
ISU55_03555	COG2205	protein histidine kinase activity
ISU55_03565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISU55_03570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU55_03575	COG3956	TIGRFAM MazG family protein
ISU55_03595	COG0602	queuosine metabolic process
ISU55_03600	COG0720	synthase
ISU55_03655	COG0529	Catalyzes the synthesis of activated sulfate
ISU55_03695	COG4942	peptidase
ISU55_03695	COG1388	LysM domain
ISU55_03700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISU55_03710	COG0698	ribose 5-phosphate isomerase
ISU55_03715	COG1063	alcohol dehydrogenase
ISU55_03720	COG1028	Short-chain dehydrogenase reductase Sdr
ISU55_03725	COG2376	Dihydroxyacetone kinase
ISU55_03740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISU55_03760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU55_03765	COG1858	cytochrome C peroxidase
ISU55_03775	COG4771	TonB-dependent receptor
ISU55_03785	COG0024	Methionine aminopeptidase
ISU55_03795	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU55_03795	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU55_03800	COG1070	Carbohydrate kinase
ISU55_03805	COG3623	hexulose-6-phosphate isomerase
ISU55_03810	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_03815	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_03820	COG1129	ABC transporter
ISU55_03830	COG1605	Chorismate mutase
ISU55_03830	COG0077	Prephenate dehydratase
ISU55_03835	COG0287	Prephenate dehydrogenase
ISU55_03835	COG1605	Chorismate mutase
ISU55_03840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU55_03845	COG3279	Response regulator of the LytR AlgR family
ISU55_03855	COG3137	Salt-induced outer membrane protein
ISU55_03900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISU55_03905	COG4137	Cytochrome C assembly protein
ISU55_03910	COG4536	flavin adenine dinucleotide binding
ISU55_03925	COG2918	glutathione biosynthetic process
ISU55_03930	COG1238	metal cluster binding
ISU55_03935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU55_03965	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISU55_04005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU55_04010	COG3958	Transketolase
ISU55_04015	COG3959	Transketolase, thiamine diphosphate binding domain
ISU55_04020	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_04025	COG1129	ABC transporter
ISU55_04035	COG1879	ABC-type sugar transport system periplasmic component
ISU55_04045	COG3783	Cytochrome b(562)
ISU55_04050	COG3038	cytochrome b561
ISU55_04055	COG3381	protein complex oligomerization
ISU55_04060	COG3302	dmso reductase anchor subunit
ISU55_04065	COG0437	4 iron, 4 sulfur cluster binding
ISU55_04070	COG0243	molybdopterin cofactor binding
ISU55_04075	COG0235	Class ii aldolase
ISU55_04080	COG1349	DNA-binding transcription factor activity
ISU55_04095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISU55_04100	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU55_04105	COG0564	pseudouridine synthase activity
ISU55_04115	COG0542	response to heat
ISU55_04145	COG5544	Lipoprotein
ISU55_04150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISU55_04155	COG1042	CoA-binding domain protein
ISU55_04155	COG0045	succinate-CoA ligase (ADP-forming) activity
ISU55_04155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU55_04160	COG3148	PFAM DTW domain containing protein
ISU55_04165	COG3118	belongs to the thioredoxin family
ISU55_04170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU55_04175	COG2814	Major facilitator Superfamily
ISU55_04180	COG1566	PFAM secretion protein HlyD family protein
ISU55_04185	COG1846	Transcriptional regulator
ISU55_04195	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISU55_04200	COG2814	Major facilitator Superfamily
ISU55_04235	COG0765	amino acid transport
ISU55_04245	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU55_04260	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU55_04285	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
ISU55_04295	COG1960	acyl-CoA dehydrogenase activity
ISU55_04305	COG0121	glutamine amidotransferase
ISU55_04310	COG3034	peptidoglycan biosynthetic process
ISU55_04320	COG1805	sodium ion transport
ISU55_04325	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU55_04345	COG1477	protein flavinylation
ISU55_04365	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU55_04370	COG0583	DNA-binding transcription factor activity
ISU55_04430	COG2226	methyltransferase
ISU55_04455	COG1940	carbohydrate kinase activity
ISU55_04460	COG0419	ATPase involved in DNA repair
ISU55_04465	COG0420	3'-5' exonuclease activity
ISU55_04470	COG0745	RESPONSE REGULATOR receiver
ISU55_04475	COG5002	protein histidine kinase activity
ISU55_04495	COG0366	Alpha amylase catalytic
ISU55_04515	COG0450	alkyl hydroperoxide reductase
ISU55_04535	COG1862	Preprotein translocase
ISU55_04540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU55_04545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU55_04570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU55_04570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU55_04585	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISU55_04590	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISU55_04605	COG0142	geranyltranstransferase activity
ISU55_04620	COG0693	protein deglycase activity
ISU55_04625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISU55_04635	COG2814	Major facilitator Superfamily
ISU55_04645	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISU55_04650	COG1845	cytochrome c oxidase, subunit III
ISU55_04655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISU55_04660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISU55_04670	COG2223	nitrite transmembrane transporter activity
ISU55_04675	COG3056	Lipoprotein
ISU55_04680	COG0271	Belongs to the BolA IbaG family
ISU55_04700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISU55_04705	COG0776	regulation of translation
ISU55_04715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU55_04720	COG1555	photosystem II stabilization
ISU55_04725	COG0824	Thioesterase
ISU55_04735	COG4533	DNA binding
ISU55_04750	COG1522	sequence-specific DNA binding
ISU55_04755	COG1132	(ABC) transporter
ISU55_04760	COG1132	(ABC) transporter
ISU55_04765	COG0347	Belongs to the P(II) protein family
ISU55_04770	COG0004	ammonium transporteR
ISU55_04775	COG1946	Acyl-CoA thioesterase
ISU55_04780	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISU55_04785	COG3695	enzyme binding
ISU55_04810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU55_04820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU55_04825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU55_04830	COG1309	transcriptional regulator
ISU55_04835	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISU55_04840	COG1196	nuclear chromosome segregation
ISU55_04840	COG3264	Mechanosensitive ion channel
ISU55_04855	COG2832	Protein of unknown function (DUF454)
ISU55_04865	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISU55_04895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU55_04895	COG0543	2 iron, 2 sulfur cluster binding
ISU55_04915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU55_04955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU55_04975	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU55_04980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU55_04985	COG4651	solute:proton antiporter activity
ISU55_04985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU55_04990	COG2223	nitrite transmembrane transporter activity
ISU55_05005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISU55_05010	COG3735	TraB family
ISU55_05015	COG2217	Heavy metal translocating P-type atpase
ISU55_05020	COG0789	Transcriptional regulator
ISU55_05025	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISU55_05030	COG0330	HflC and HflK could
ISU55_05035	COG3118	belongs to the thioredoxin family
ISU55_05040	COG0300	oxidoreductase activity
ISU55_05045	COG2755	lipolytic protein G-D-S-L family
ISU55_05050	COG4181	ATPase activity
ISU55_05055	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISU55_05060	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISU55_05065	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISU55_05075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU55_05090	COG2501	S4 domain
ISU55_05125	COG0582	viral genome integration into host DNA
ISU55_05135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISU55_05140	COG4589	Belongs to the CDS family
ISU55_05150	COG2267	carboxylic ester hydrolase activity
ISU55_05155	COG2453	phosphatase
ISU55_05155	COG0671	phosphoesterase, PA-phosphatase related
ISU55_05185	COG0667	Aldo Keto reductase
ISU55_05190	COG0656	L-ascorbic acid biosynthetic process
ISU55_05200	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU55_05215	COG3328	transposase activity
ISU55_05270	COG3423	Transcriptional regulator
ISU55_05275	COG4953	penicillin-binding protein 1C
ISU55_05285	COG2373	Large extracellular alpha-helical protein
ISU55_05305	COG3962	Belongs to the TPP enzyme family
ISU55_05320	COG1129	ABC transporter
ISU55_05325	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_05330	COG0673	inositol 2-dehydrogenase activity
ISU55_05335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU55_05345	COG3718	enzyme involved in inositol metabolism
ISU55_05355	COG5265	(ABC) transporter
ISU55_05380	COG2197	response regulator
ISU55_05385	COG1278	Cold shock
ISU55_05395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU55_05400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU55_05420	COG1686	Belongs to the peptidase S11 family
ISU55_05425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU55_05430	COG0772	Belongs to the SEDS family
ISU55_05435	COG0768	penicillin binding
ISU55_05445	COG0799	negative regulation of ribosome biogenesis
ISU55_05455	COG1466	dna polymerase III delta subunit
ISU55_05470	COG2888	peptidyl-tyrosine sulfation
ISU55_05475	COG1126	abc transporter atp-binding protein
ISU55_05480	COG0765	amino acid transport
ISU55_05485	COG0765	amino acid transport
ISU55_05495	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ISU55_05500	COG4535	Mg2 and Co2 transporter CorC
ISU55_05510	COG1702	phosphate starvation-inducible protein PhoH
ISU55_05515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISU55_05520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU55_05555	COG0367	asparagine synthase
ISU55_05560	COG0647	UMP catabolic process
ISU55_05565	COG1846	Transcriptional regulator
ISU55_05565	COG1940	carbohydrate kinase activity
ISU55_05570	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISU55_05580	COG1263	PTS System
ISU55_05580	COG2190	(PTS) system
ISU55_05580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU55_05605	COG0735	belongs to the Fur family
ISU55_05620	COG0596	Alpha beta hydrolase
ISU55_05630	COG0582	viral genome integration into host DNA
ISU55_05665	COG2113	Glycine betaine
ISU55_05670	COG4176	ABC-type proline glycine betaine transport system permease component
ISU55_05675	COG4175	Glycine betaine
ISU55_05680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISU55_05720	COG1278	Cold shock
ISU55_05725	COG0747	negative chemotaxis
ISU55_05735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU55_05740	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ISU55_05745	COG1124	(ABC) transporter
ISU55_05750	COG0831	urea catabolic process
ISU55_05775	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISU55_05785	COG4413	Urea transporter
ISU55_05790	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU55_05800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU55_05810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU55_05820	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU55_05825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU55_05830	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISU55_05835	COG2169	Transcriptional regulator
ISU55_05835	COG1917	Cupin 2, conserved barrel domain protein
ISU55_05850	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ISU55_05855	COG0033	Phosphoglucomutase
ISU55_05870	COG0745	RESPONSE REGULATOR receiver
ISU55_05875	COG2205	protein histidine kinase activity
ISU55_05910	COG3272	Protein of unknown function (DUF1722)
ISU55_05920	COG5212	phosphodiesterase
ISU55_05925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ISU55_05940	COG1984	allophanate hydrolase subunit 2
ISU55_05985	COG0513	Belongs to the DEAD box helicase family
ISU55_05995	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISU55_06010	COG3026	antisigma factor binding
ISU55_06015	COG3086	response to oxidative stress
ISU55_06050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISU55_06065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU55_06070	COG1737	Transcriptional regulator
ISU55_06080	COG0560	Phosphoserine phosphatase
ISU55_06125	COG2205	protein histidine kinase activity
ISU55_06130	COG3170	Tfp pilus assembly protein FimV
ISU55_06135	COG2204	response regulator
ISU55_06140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU55_06140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISU55_06145	COG0347	Belongs to the P(II) protein family
ISU55_06170	COG1017	nitric oxide dioxygenase activity
ISU55_06170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU55_06190	COG2814	Major facilitator Superfamily
ISU55_06195	COG3711	transcriptional antiterminator
ISU55_06200	COG3683	transport system, periplasmic component
ISU55_06205	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU55_06225	COG1104	cysteine desulfurase activity
ISU55_06230	COG0822	iron-sulfur transferase activity
ISU55_06250	COG0633	Ferredoxin
ISU55_06255	COG2975	iron-sulfur cluster assembly
ISU55_06280	COG3468	outer membrane autotransporter barrel domain protein
ISU55_06285	COG3468	outer membrane autotransporter barrel domain protein
ISU55_06325	COG2976	Protein conserved in bacteria
ISU55_06330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU55_06345	COG1645	bacterial-type flagellum-dependent swarming motility
ISU55_06355	COG0517	IMP dehydrogenase activity
ISU55_06355	COG0516	GMP reductase activity
ISU55_06400	COG3328	transposase activity
ISU55_06415	COG0351	phosphomethylpyrimidine kinase
ISU55_06440	COG0826	peptidase U32
ISU55_06445	COG3422	double-strand break repair
ISU55_06450	COG0745	RESPONSE REGULATOR receiver
ISU55_06480	COG3842	ATPase activity
ISU55_06490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISU55_06500	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU55_06505	COG1177	transmembrane transport
ISU55_06510	COG0443	Heat shock 70 kDa protein
ISU55_06515	COG2239	Acts as a magnesium transporter
ISU55_06530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISU55_06540	COG0581	inorganic phosphate transmembrane transporter activity
ISU55_06555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU55_06560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISU55_06585	COG1393	Belongs to the ArsC family
ISU55_06590	COG4783	chaperone-mediated protein folding
ISU55_06595	COG0628	permease
ISU55_06605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISU55_06610	COG2716	regulation of RNA biosynthetic process
ISU55_06620	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISU55_06635	COG2321	neutral zinc metallopeptidase
ISU55_06655	COG1876	peptidase activity
ISU55_06665	COG1393	Belongs to the ArsC family
ISU55_06680	COG1175	transmembrane transport
ISU55_06685	COG3842	ATPase activity
ISU55_06695	COG3119	arylsulfatase activity
ISU55_06700	COG0641	radical SAM
ISU55_06705	COG1988	membrane-bound metal-dependent
ISU55_06715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU55_06725	COG2197	response regulator
ISU55_06730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU55_06730	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU55_06735	COG3062	negative regulation of establishment of protein localization
ISU55_06745	COG3043	anaerobic respiration
ISU55_06750	COG3005	denitrification pathway
ISU55_06805	COG3111	PFAM Bacterial OB fold (BOF) protein
ISU55_06815	COG2837	iron assimilation
ISU55_06820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISU55_06830	COG4886	Leucine-rich repeat (LRR) protein
ISU55_06840	COG2731	YhcH YjgK YiaL family protein
ISU55_06845	COG1737	Transcriptional regulator
ISU55_06855	COG4150	thiosulfate binding
ISU55_06860	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISU55_06865	COG4208	sulfate ABC transporter
ISU55_06870	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISU55_06885	COG0745	RESPONSE REGULATOR receiver
ISU55_06890	COG3850	Histidine kinase
ISU55_06890	COG5002	protein histidine kinase activity
ISU55_06900	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISU55_06920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISU55_06935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU55_06940	COG0745	RESPONSE REGULATOR receiver
ISU55_06945	COG2205	protein histidine kinase activity
ISU55_06975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU55_06985	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ISU55_07000	COG3530	Putative quorum-sensing-regulated virulence factor
ISU55_07060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU55_07075	COG0667	Aldo Keto reductase
ISU55_07100	COG0436	Aminotransferase
ISU55_07105	COG3038	cytochrome b561
ISU55_07135	COG3381	protein complex oligomerization
ISU55_07140	COG3302	dmso reductase anchor subunit
ISU55_07145	COG0437	4 iron, 4 sulfur cluster binding
ISU55_07150	COG0243	molybdopterin cofactor binding
ISU55_07245	COG3121	Chaperone
ISU55_07250	COG3188	usher protein
ISU55_07255	COG3328	transposase activity
ISU55_07260	COG3188	usher protein
ISU55_07350	COG2824	Alkylphosphonate utilization operon protein PhnA
ISU55_07360	COG1704	LemA family
ISU55_07380	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU55_07385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU55_07390	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU55_07400	COG1138	Cytochrome C-type biogenesis protein
ISU55_07405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU55_07410	COG4235	cytochrome complex assembly
ISU55_07410	COG3088	subunit of a heme lyase
ISU55_07415	COG3088	subunit of a heme lyase
ISU55_07415	COG4235	cytochrome complex assembly
ISU55_07430	COG3691	Protein conserved in bacteria
ISU55_07445	COG2062	phosphohistidine phosphatase, SixA
ISU55_07460	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU55_07475	COG0730	response to heat
ISU55_07480	COG3101	peptidyl-lysine hydroxylation
ISU55_07495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU55_07500	COG1794	racemase activity, acting on amino acids and derivatives
ISU55_07515	COG0697	spore germination
ISU55_07530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU55_07540	COG0586	Pfam SNARE associated Golgi protein
ISU55_07550	COG0285	dihydrofolate synthase activity
ISU55_07555	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISU55_07560	COG1286	toxin biosynthetic process
ISU55_07565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISU55_07575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU55_07580	COG4215	(ABC) transporter
ISU55_07585	COG4160	amino acid transport
ISU55_07590	COG4598	ABC transporter
ISU55_07595	COG1090	epimerase
ISU55_07605	COG0622	Phosphoesterase
ISU55_07610	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISU55_07615	COG3037	sugar-specific permease SgaT UlaA
ISU55_07620	COG3328	transposase activity
ISU55_07635	COG1609	Transcriptional regulator
ISU55_07640	COG0857	belongs to the CobB CobQ family
ISU55_07640	COG0280	phosphate acetyltransferase
ISU55_07660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU55_07665	COG0490	domain, Protein
ISU55_07665	COG0471	metal ion transport
ISU55_07675	COG0436	Aminotransferase
ISU55_07680	COG0583	DNA-binding transcription factor activity
ISU55_07690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU55_07710	COG1034	ATP synthesis coupled electron transport
ISU55_07725	COG0839	Belongs to the complex I subunit 6 family
ISU55_07735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISU55_07740	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU55_07760	COG1028	Short-chain dehydrogenase reductase Sdr
ISU55_07765	COG3265	gluconokinase activity
ISU55_07780	COG1649	PFAM Uncharacterised BCR, COG1649
ISU55_07785	COG1609	Transcriptional regulator
ISU55_07790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU55_07805	COG0129	dihydroxy-acid dehydratase activity
ISU55_07810	COG4575	ribosome binding
ISU55_07820	COG1169	isochorismate synthase
ISU55_07835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ISU55_07850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISU55_07885	COG1126	abc transporter atp-binding protein
ISU55_07890	COG0765	amino acid transport
ISU55_07895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU55_07925	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISU55_07945	COG1063	alcohol dehydrogenase
ISU55_07950	COG1879	ABC-type sugar transport system periplasmic component
ISU55_07955	COG1129	ABC transporter
ISU55_07960	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_07965	COG1609	Transcriptional regulator
ISU55_07970	COG0583	DNA-binding transcription factor activity
ISU55_07975	COG0473	3-isopropylmalate dehydrogenase activity
ISU55_07985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISU55_07995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU55_08000	COG2831	hemolysin activation secretion protein
ISU55_08045	COG3210	domain, Protein
ISU55_08055	COG3842	ATPase activity
ISU55_08065	COG1609	Transcriptional regulator
ISU55_08080	COG0395	ABC-type sugar transport system, permease component
ISU55_08085	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ISU55_08105	COG0668	transmembrane transport
ISU55_08110	COG1518	maintenance of DNA repeat elements
ISU55_08115	COG1203	CRISPR-associated helicase, Cas3
ISU55_08140	COG0667	Aldo Keto reductase
ISU55_08160	COG0583	DNA-binding transcription factor activity
ISU55_08165	COG2771	luxR family
ISU55_08170	COG3916	Acyl-homoserine-lactone synthase
ISU55_08190	COG0628	permease
ISU55_08210	COG3328	transposase activity
ISU55_08220	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISU55_08240	COG3328	transposase activity
ISU55_08245	COG1530	ribonuclease E activity
ISU55_08250	COG0564	pseudouridine synthase activity
ISU55_08255	COG0424	maF-like protein
ISU55_08260	COG1399	metal-binding, possibly nucleic acid-binding protein
ISU55_08265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISU55_08295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU55_08305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU55_08310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISU55_08320	COG0470	DNA polymerase III
ISU55_08325	COG0084	hydrolase, TatD family'
ISU55_08330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU55_08330	COG1263	PTS System
ISU55_08340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISU55_08345	COG0537	adenosine 5'-monophosphoramidase activity
ISU55_08350	COG5633	Lipoprotein
ISU55_08365	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU55_08375	COG1252	NADH dehydrogenase
ISU55_08390	COG3328	transposase activity
ISU55_08395	COG3134	Outer membrane lipoprotein
ISU55_08400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISU55_08405	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU55_08415	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU55_08420	COG1940	carbohydrate kinase activity
ISU55_08440	COG2850	peptidyl-arginine hydroxylation
ISU55_08450	COG0745	RESPONSE REGULATOR receiver
ISU55_08460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISU55_08480	COG1187	pseudouridine synthase activity
ISU55_08485	COG0538	isocitrate dehydrogenase activity
ISU55_08500	COG0840	transmembrane signaling receptor activity
ISU55_08505	COG0702	epimerase
ISU55_08510	COG1733	regulation of RNA biosynthetic process
ISU55_08535	COG1522	sequence-specific DNA binding
ISU55_08550	COG1028	Short-chain dehydrogenase reductase Sdr
ISU55_08550	COG3321	synthase
ISU55_08550	COG0604	alcohol dehydrogenase
ISU55_08585	COG1285	pathogenesis
ISU55_08610	COG1360	Flagellar Motor Protein
ISU55_08615	COG2198	Histidine kinase
ISU55_08615	COG0643	Histidine kinase
ISU55_08620	COG0835	chemotaxis
ISU55_08625	COG2271	Major facilitator Superfamily
ISU55_08630	COG0251	oxidation-reduction process
ISU55_08640	COG2964	Protein conserved in bacteria
ISU55_08660	COG0840	transmembrane signaling receptor activity
ISU55_08665	COG0840	transmembrane signaling receptor activity
ISU55_08670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ISU55_08680	COG0745	RESPONSE REGULATOR receiver
ISU55_08685	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISU55_08690	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU55_08700	COG5295	Hep Hag repeat protein
ISU55_08710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISU55_08765	COG3121	Chaperone
ISU55_08785	COG3008	intermembrane lipid transfer
ISU55_08790	COG2995	paraquat-inducible protein a
ISU55_08795	COG1956	GAF domain-containing protein
ISU55_08805	COG0793	Belongs to the peptidase S41A family
ISU55_08815	COG3539	Fimbrial protein
ISU55_08820	COG3121	Chaperone
ISU55_08835	COG3121	Chaperone
ISU55_08840	COG2814	Major facilitator Superfamily
ISU55_08845	COG0823	Involved in the tonB-independent uptake of proteins
ISU55_08855	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU55_08860	COG1823	symporter activity
ISU55_08865	COG1988	membrane-bound metal-dependent
ISU55_08870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU55_08875	COG1653	transport
ISU55_08880	COG3842	ATPase activity
ISU55_08885	COG0395	ABC-type sugar transport system, permease component
ISU55_08890	COG1175	transmembrane transport
ISU55_08900	COG1028	Short-chain dehydrogenase reductase Sdr
ISU55_08910	COG1917	Cupin 2, conserved barrel domain protein
ISU55_08915	COG3328	transposase activity
ISU55_08920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU55_08930	COG3001	Fructosamine kinase
ISU55_08940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU55_08945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU55_08950	COG1121	(ABC) transporter
ISU55_08955	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISU55_08975	COG4249	Peptidase C14 caspase catalytic subunit p20
ISU55_09010	COG0072	phenylalanine-tRNA ligase activity
ISU55_09010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISU55_09015	COG0776	regulation of translation
ISU55_09030	COG0386	Belongs to the glutathione peroxidase family
ISU55_09080	COG0791	NLP P60 protein
ISU55_09105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU55_09105	COG0574	Belongs to the PEP-utilizing enzyme family
ISU55_09115	COG0628	permease
ISU55_09120	COG0277	FAD linked oxidase domain protein
ISU55_09120	COG0247	lactate metabolic process
ISU55_09125	COG2050	protein possibly involved in aromatic compounds catabolism
ISU55_09130	COG0316	Belongs to the HesB IscA family
ISU55_09135	COG0719	Fe-S assembly protein
ISU55_09140	COG0396	ATPase activity
ISU55_09145	COG0719	Fe-S assembly protein
ISU55_09160	COG1376	ErfK ybiS ycfS ynhG family protein
ISU55_09160	COG1388	LysM domain
ISU55_09215	COG0307	riboflavin synthase, alpha
ISU55_09220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISU55_09225	COG2814	Major facilitator Superfamily
ISU55_09230	COG0583	DNA-binding transcription factor activity
ISU55_09250	COG0791	NLP P60 protein
ISU55_09255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISU55_09265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISU55_09270	COG0346	lactoylglutathione lyase activity
ISU55_09280	COG1309	transcriptional regulator
ISU55_09285	COG2194	sulfuric ester hydrolase activity
ISU55_09295	COG3133	Outer membrane lipoprotein
ISU55_09305	COG3895	Periplasmic Protein
ISU55_09325	COG0625	glutathione transferase activity
ISU55_09340	COG3104	oligopeptide transport
ISU55_09345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU55_09345	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU55_09350	COG4172	Belongs to the ABC transporter superfamily
ISU55_09360	COG4171	peptide transport system, permease
ISU55_09365	COG4168	peptide transport system, permease
ISU55_09370	COG4166	transmembrane transport
ISU55_09380	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISU55_09385	COG1842	Phage shock protein A
ISU55_09395	COG1983	PspC domain protein
ISU55_09405	COG3106	COG3106 Predicted ATPase
ISU55_09415	COG5654	RES domain protein
ISU55_09420	COG5642	Protein of unknown function (DUF2384)
ISU55_09450	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISU55_09455	COG4948	Mandelate Racemase Muconate Lactonizing
ISU55_09460	COG2866	Carboxypeptidase
ISU55_09465	COG4166	transmembrane transport
ISU55_09480	COG0657	acetylesterase activity
ISU55_09490	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISU55_09490	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISU55_09490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU55_09490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISU55_09500	COG1285	pathogenesis
ISU55_09505	COG3042	response to heat
ISU55_09510	COG3187	Heat shock protein
ISU55_09515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU55_09520	COG2911	Protein conserved in bacteria
ISU55_09530	COG3784	Protein of unknown function (DUF1318)
ISU55_09535	COG0246	Mannitol dehydrogenase
ISU55_09540	COG2390	Transcriptional regulator
ISU55_09550	COG1643	Atp-dependent helicase
ISU55_09565	COG3591	Belongs to the peptidase S1B family
ISU55_09605	COG1454	alcohol dehydrogenase
ISU55_09605	COG1012	belongs to the aldehyde dehydrogenase family
ISU55_09610	COG2095	MarC family integral membrane protein
ISU55_09620	COG0601	transmembrane transport
ISU55_09625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU55_09630	COG0444	Belongs to the ABC transporter superfamily
ISU55_09635	COG4608	Belongs to the ABC transporter superfamily
ISU55_09680	COG2350	Protein conserved in bacteria
ISU55_09685	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ISU55_09690	COG3328	transposase activity
ISU55_09725	COG3047	cAMP biosynthetic process
ISU55_09745	COG0135	phosphoribosylanthranilate isomerase activity
ISU55_09745	COG0134	indole-3-glycerol-phosphate synthase activity
ISU55_09755	COG0512	Glutamine amidotransferase of anthranilate synthase
ISU55_09775	COG0009	L-threonylcarbamoyladenylate synthase
ISU55_09780	COG1187	pseudouridine synthase activity
ISU55_09790	COG1028	Short-chain dehydrogenase reductase Sdr
ISU55_09795	COG0616	signal peptide processing
ISU55_09815	COG0583	DNA-binding transcription factor activity
ISU55_09825	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISU55_09835	COG0671	phosphoesterase, PA-phosphatase related
ISU55_09840	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISU55_09845	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISU55_09860	COG0023	Translation Initiation Factor
ISU55_09880	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISU55_09885	COG2879	small protein
ISU55_09890	COG1966	Carbon starvation protein
ISU55_09900	COG2271	Major facilitator Superfamily
ISU55_09905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU55_09910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISU55_09920	COG4659	FMN binding
ISU55_09925	COG4658	electron transport chain
ISU55_09930	COG2207	Transcriptional regulator
ISU55_09930	COG3708	Transcriptional regulator
ISU55_09960	COG1132	(ABC) transporter
ISU55_09970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU55_09975	COG2274	protein secretion by the type I secretion system
ISU55_09990	COG1879	ABC-type sugar transport system periplasmic component
ISU55_09995	COG1129	ABC transporter
ISU55_10000	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_10010	COG0673	inositol 2-dehydrogenase activity
ISU55_10015	COG0385	Bile acid
ISU55_10025	COG5339	Protein conserved in bacteria
ISU55_10035	COG0114	fumarate hydratase activity
ISU55_10045	COG2814	Major facilitator Superfamily
ISU55_10050	COG0583	DNA-binding transcription factor activity
ISU55_10055	COG1940	carbohydrate kinase activity
ISU55_10060	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISU55_10065	COG0038	chloride channel
ISU55_10070	COG1609	Transcriptional regulator
ISU55_10090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU55_10100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISU55_10130	COG0028	Belongs to the TPP enzyme family
ISU55_10135	COG0440	acetolactate synthase activity
ISU55_10140	COG1011	Hydrolase
ISU55_10155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU55_10160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISU55_10165	COG0589	response to stress
ISU55_10170	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISU55_10175	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISU55_10185	COG0531	amino acid
ISU55_10195	COG0745	RESPONSE REGULATOR receiver
ISU55_10200	COG2205	protein histidine kinase activity
ISU55_10205	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISU55_10240	COG0745	RESPONSE REGULATOR receiver
ISU55_10250	COG0788	formyltetrahydrofolate deformylase activity
ISU55_10255	COG3328	transposase activity
ISU55_10275	COG0583	DNA-binding transcription factor activity
ISU55_10280	COG0708	Exodeoxyribonuclease III
ISU55_10285	COG0494	nUDIX hydrolase
ISU55_10295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISU55_10300	COG0709	Synthesizes selenophosphate from selenide and ATP
ISU55_10305	COG0778	Nitroreductase
ISU55_10310	COG0616	signal peptide processing
ISU55_10315	COG0252	asparaginase activity
ISU55_10320	COG1335	isochorismatase
ISU55_10325	COG3139	Protein of unknown function (DUF1315)
ISU55_10345	COG3713	MltA-interacting MipA family protein
ISU55_10350	COG2766	serine protein kinase
ISU55_10365	COG0583	DNA-binding transcription factor activity
ISU55_10375	COG2814	Major facilitator Superfamily
ISU55_10385	COG2719	SpoVR family
ISU55_10415	COG1104	cysteine desulfurase activity
ISU55_10425	COG3328	transposase activity
ISU55_10585	COG3328	transposase activity
ISU55_10685	COG0582	viral genome integration into host DNA
ISU55_10695	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISU55_10700	COG2951	lytic endotransglycosylase activity
ISU55_10715	COG2894	cell division
ISU55_10720	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISU55_10725	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ISU55_10730	COG0318	PFAM AMP-dependent synthetase and ligase
ISU55_10740	COG3065	identical protein binding
ISU55_10750	COG1199	ATP-dependent helicase activity
ISU55_10755	COG0251	oxidation-reduction process
ISU55_10770	COG0800	Aldolase
ISU55_10775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISU55_10780	COG1737	Transcriptional regulator
ISU55_10785	COG0469	pyruvate kinase activity
ISU55_10795	COG1560	Kdo2-lipid A biosynthetic process
ISU55_10800	COG0739	heme binding
ISU55_10805	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISU55_10815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU55_10840	COG0494	nUDIX hydrolase
ISU55_10850	COG1801	Protein of unknown function DUF72
ISU55_10855	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISU55_10875	COG3102	Protein conserved in bacteria
ISU55_10895	COG0728	peptidoglycan biosynthetic process
ISU55_10905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU55_10920	COG3381	protein complex oligomerization
ISU55_10935	COG1940	carbohydrate kinase activity
ISU55_10940	COG0584	glycerophosphoryl diester phosphodiesterase
ISU55_10960	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU55_10965	COG3833	ABC-type maltose transport systems, permease component
ISU55_10985	COG0659	secondary active sulfate transmembrane transporter activity
ISU55_11005	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU55_11030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISU55_11045	COG0012	GTP binding
ISU55_11095	COG5002	protein histidine kinase activity
ISU55_11140	COG0500	methyltransferase
ISU55_11160	COG3328	transposase activity
ISU55_11205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU55_11210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU55_11215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU55_11230	COG0402	S-adenosylhomocysteine deaminase activity
ISU55_11280	COG3842	ATPase activity
ISU55_11285	COG0395	ABC-type sugar transport system, permease component
ISU55_11290	COG1175	transmembrane transport
ISU55_11300	COG0673	inositol 2-dehydrogenase activity
ISU55_11305	COG2188	Transcriptional regulator
ISU55_11430	COG2197	response regulator
ISU55_11440	COG3136	membrane protein required for alginate biosynthesis
ISU55_11460	COG1113	amino acid transport
ISU55_11480	COG2822	iron ion transport
ISU55_11485	COG0672	)-iron permease
ISU55_11500	COG0506	proline dehydrogenase activity
ISU55_11500	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU55_11500	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU55_11515	COG1126	abc transporter atp-binding protein
ISU55_11520	COG0765	amino acid transport
ISU55_11525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU55_11540	COG1191	sigma factor activity
ISU55_11570	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ISU55_11575	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISU55_11580	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISU55_11600	COG1677	Flagellar hook-basal body complex protein FliE
ISU55_11620	COG1157	protein secretion by the type III secretion system
ISU55_11635	COG1580	Controls the rotational direction of flagella during chemotaxis
ISU55_11660	COG1987	bacterial-type flagellum assembly
ISU55_11680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU55_11685	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_11690	COG1129	ABC transporter
ISU55_11700	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_11705	COG1028	Short-chain dehydrogenase reductase Sdr
ISU55_11705	COG3347	Dehydrogenase
ISU55_11710	COG2390	Transcriptional regulator
ISU55_11720	COG1256	bacterial-type flagellum assembly
ISU55_11760	COG1558	bacterial-type flagellum-dependent cell motility
ISU55_11765	COG1815	bacterial-type flagellum-dependent cell motility
ISU55_11775	COG2747	anti-sigma28 factor FlgM
ISU55_11780	COG3418	PFAM FlgN family protein
ISU55_11805	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU55_11810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU55_11835	COG2372	response to copper ion
ISU55_11840	COG1528	Iron-storage protein
ISU55_11855	COG1770	oligopeptidase
ISU55_11870	COG3141	response to X-ray
ISU55_11875	COG0513	Belongs to the DEAD box helicase family
ISU55_11900	COG1760	l-serine dehydratase
ISU55_11905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISU55_11910	COG2368	4-hydroxyphenylacetate
ISU55_11925	COG3971	2-oxopent-4-enoate hydratase activity
ISU55_11935	COG3384	dioxygenase
ISU55_11940	COG1012	belongs to the aldehyde dehydrogenase family
ISU55_11955	COG1846	Transcriptional regulator
ISU55_11960	COG1253	flavin adenine dinucleotide binding
ISU55_11965	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU55_11965	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU55_11970	COG3715	PTS system
ISU55_11975	COG3716	PTS system mannose fructose sorbose family IID component
ISU55_12025	COG1132	(ABC) transporter
ISU55_12035	COG2207	Transcriptional regulator
ISU55_12070	COG1113	amino acid transport
ISU55_12090	COG1496	oxidoreductase activity
ISU55_12095	COG2226	methyltransferase
ISU55_12135	COG3328	transposase activity
ISU55_12140	COG2223	nitrite transmembrane transporter activity
ISU55_12160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISU55_12185	COG3122	Protein conserved in bacteria
ISU55_12205	COG0534	Mate efflux family protein
ISU55_12220	COG4948	Mandelate Racemase Muconate Lactonizing
ISU55_12230	COG1028	Short-chain dehydrogenase reductase Sdr
ISU55_12235	COG3011	Protein conserved in bacteria
ISU55_12240	COG2271	Major facilitator Superfamily
ISU55_12245	COG1470	cell adhesion involved in biofilm formation
ISU55_12245	COG1388	LysM domain
ISU55_12250	COG3328	transposase activity
ISU55_12265	COG2925	Exonuclease
ISU55_12275	COG0531	amino acid
ISU55_12280	COG0371	Dehydrogenase
ISU55_12285	COG1129	ABC transporter
ISU55_12290	COG1129	ABC transporter
ISU55_12295	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_12310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU55_12325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISU55_12335	COG0131	Imidazoleglycerol-phosphate dehydratase
ISU55_12335	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU55_12355	COG0140	phosphoribosyl-ATP diphosphatase activity
ISU55_12355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISU55_12365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU55_12370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU55_12385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU55_12390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU55_12395	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU55_12400	COG1120	ATPase activity
ISU55_12415	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ISU55_12420	COG0076	glutamate decarboxylase activity
ISU55_12425	COG4114	ferric iron reductase
ISU55_12430	COG1253	flavin adenine dinucleotide binding
ISU55_12435	COG2982	Protein involved in outer membrane biogenesis
ISU55_12450	COG0489	protein tyrosine kinase activity
ISU55_12480	COG2814	Major facilitator Superfamily
ISU55_12490	COG1346	cytolysis
ISU55_12505	COG2949	membrane
ISU55_12510	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISU55_12525	COG2311	Membrane
ISU55_12535	COG0477	Major facilitator Superfamily
ISU55_12540	COG0583	DNA-binding transcription factor activity
ISU55_12570	COG1136	(ABC) transporter
ISU55_12580	COG0303	'Molybdopterin
ISU55_12590	COG3328	transposase activity
ISU55_12600	COG0488	(ABC) transporter
ISU55_12730	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISU55_12735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISU55_12745	COG1028	Short-chain dehydrogenase reductase Sdr
ISU55_12750	COG1024	Enoyl-CoA hydratase
ISU55_12760	COG3425	synthase
ISU55_12765	COG1028	Short-chain dehydrogenase reductase Sdr
ISU55_12770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU55_12775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISU55_12785	COG1028	Short-chain dehydrogenase reductase Sdr
ISU55_12810	COG2920	part of a sulfur-relay system
ISU55_12830	COG1832	CoA-binding protein
ISU55_12845	COG0210	DNA helicase
ISU55_12850	COG3304	Inner membrane component domain
ISU55_12855	COG1289	transmembrane transporter activity
ISU55_12860	COG3070	regulator of competence-specific genes
ISU55_12885	COG1067	ATP-dependent peptidase activity
ISU55_12925	COG3130	regulation of translation
ISU55_12930	COG3009	Protein conserved in bacteria
ISU55_12935	COG3008	intermembrane lipid transfer
ISU55_12935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU55_12940	COG2995	paraquat-inducible protein a
ISU55_12945	COG0488	(ABC) transporter
ISU55_12955	COG3217	Mosc domain protein beta barrel domain protein
ISU55_12955	COG0633	Ferredoxin
ISU55_12970	COG0308	aminopeptidase N
ISU55_12990	COG1448	Aminotransferase
ISU55_13000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU55_13005	COG3108	Peptidase M15
ISU55_13010	COG2989	Protein conserved in bacteria
ISU55_13035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISU55_13040	COG3173	Aminoglycoside phosphotransferase
ISU55_13055	COG1278	Cold shock
ISU55_13060	COG5383	Protein conserved in bacteria
ISU55_13075	COG2333	competence protein COMEC
ISU55_13075	COG0658	competence protein
ISU55_13085	COG0539	negative regulation of cytoplasmic translation
ISU55_13110	COG5295	Hep Hag repeat protein
ISU55_13110	COG5295	Hep Hag repeat protein
ISU55_13115	COG0252	asparaginase activity
ISU55_13120	COG1944	ATP diphosphatase activity
ISU55_13125	COG2116	formate transmembrane transporter activity
ISU55_13130	COG1882	Formate acetyltransferase
ISU55_13140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISU55_13170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISU55_13180	COG3107	peptidoglycan biosynthetic process
ISU55_13180	COG1674	ftsk spoiiie
ISU55_13190	COG0492	ferredoxin-NADP+ reductase activity
ISU55_13200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISU55_13210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ISU55_13220	COG0542	response to heat
ISU55_13230	COG1278	Cold shock
ISU55_13240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU55_13245	COG2990	Protein conserved in bacteria
ISU55_13250	COG3593	DNA synthesis involved in DNA repair
ISU55_13255	COG2431	L-lysine efflux transmembrane transporter activity
ISU55_13265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU55_13270	COG0028	Belongs to the TPP enzyme family
ISU55_13280	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISU55_13285	COG0702	epimerase
ISU55_13290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU55_13300	COG1605	Chorismate mutase
ISU55_13305	COG1126	abc transporter atp-binding protein
ISU55_13310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU55_13315	COG4215	(ABC) transporter
ISU55_13320	COG4160	amino acid transport
ISU55_13345	COG1120	ATPase activity
ISU55_13350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU55_13355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU55_13380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU55_13395	COG1177	transmembrane transport
ISU55_13400	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU55_13405	COG3842	ATPase activity
ISU55_13410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISU55_13440	COG0671	phosphoesterase, PA-phosphatase related
ISU55_13450	COG1349	DNA-binding transcription factor activity
ISU55_13455	COG0814	amino acid
ISU55_13460	COG1686	Belongs to the peptidase S11 family
ISU55_13465	COG2011	ABC-type metal ion transport system permease component
ISU55_13490	COG0625	glutathione transferase activity
ISU55_13495	COG4771	TonB-dependent receptor
ISU55_13505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU55_13515	COG0833	amino acid
ISU55_13520	COG0583	DNA-binding transcription factor activity
ISU55_13525	COG2855	membrane
ISU55_13535	COG3188	usher protein
ISU55_13540	COG3121	Chaperone
ISU55_13555	COG3710	Transcriptional regulator
ISU55_13560	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISU55_13560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU55_13560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU55_13565	COG1105	Belongs to the carbohydrate kinase PfkB family
ISU55_13575	COG0494	nUDIX hydrolase
ISU55_13585	COG1129	ABC transporter
ISU55_13620	COG1028	Short-chain dehydrogenase reductase Sdr
ISU55_13645	COG0246	Mannitol dehydrogenase
ISU55_13650	COG2186	Transcriptional regulator
ISU55_13655	COG0523	cobalamin synthesis protein
ISU55_13660	COG0671	phosphoesterase, PA-phosphatase related
ISU55_13665	COG0791	NLP P60 protein
ISU55_13670	COG2200	EAL domain
ISU55_13675	COG4166	transmembrane transport
ISU55_13680	COG4174	ABC transporter (Permease)
ISU55_13685	COG4239	(ABC) transporter, permease
ISU55_13690	COG4172	Belongs to the ABC transporter superfamily
ISU55_13700	COG2814	Major facilitator Superfamily
ISU55_13705	COG1187	pseudouridine synthase activity
ISU55_13710	COG1061	Type III restriction enzyme res subunit
ISU55_13730	COG3082	Protein of unknown function (DUF1414)
ISU55_13735	COG3083	sulfuric ester hydrolase activity
ISU55_13750	COG3157	Type VI secretion system effector, Hcp
ISU55_13770	COG2723	6-phospho-beta-galactosidase activity
ISU55_13775	COG1737	Transcriptional regulator
ISU55_13795	COG3299	homolog of phage Mu protein gp47
ISU55_13835	COG4386	tail sheath protein
ISU55_13855	COG3622	Belongs to the hyi family
ISU55_13860	COG1349	DNA-binding transcription factor activity
ISU55_13870	COG3395	kinase activity
ISU55_13910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISU55_13935	COG2223	nitrite transmembrane transporter activity
ISU55_13940	COG2198	Histidine kinase
ISU55_13940	COG0642	Histidine kinase
ISU55_13945	COG2198	Histidine kinase
ISU55_13945	COG0642	Histidine kinase
ISU55_13955	COG2205	protein histidine kinase activity
ISU55_13955	COG0784	Response regulator, receiver
ISU55_13980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU55_13995	COG0814	amino acid
ISU55_14020	COG0697	spore germination
ISU55_14030	COG1982	Orn Lys Arg decarboxylase major
ISU55_14035	COG0531	amino acid
ISU55_14040	COG1174	glycine betaine transport
ISU55_14045	COG1125	glycine betaine transport
ISU55_14050	COG1174	glycine betaine transport
ISU55_14060	COG2897	thiosulfate sulfurtransferase activity
ISU55_14080	COG1122	ATPase activity
ISU55_14100	COG4807	Protein conserved in bacteria
ISU55_14115	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISU55_14125	COG2261	transglycosylase associated protein
ISU55_14145	COG0277	FAD linked oxidase domain protein
ISU55_14150	COG1686	Belongs to the peptidase S11 family
ISU55_14160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU55_14185	COG3328	transposase activity
ISU55_14220	COG0513	Belongs to the DEAD box helicase family
ISU55_14225	COG1309	transcriptional regulator
ISU55_14235	COG1131	(ABC) transporter
ISU55_14240	COG0842	Transport permease protein
ISU55_14245	COG0842	Transport permease protein
ISU55_14265	COG1902	pentaerythritol trinitrate reductase activity
ISU55_14300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISU55_14310	COG0583	DNA-binding transcription factor activity
ISU55_14315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISU55_14340	COG0670	Belongs to the BI1 family
ISU55_14345	COG0314	molybdopterin synthase activity
ISU55_14350	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISU55_14360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISU55_14365	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ISU55_14370	COG4628	conserved protein (DUF2132)
ISU55_14380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISU55_14390	COG2226	methyltransferase
ISU55_14415	COG0561	phosphatase activity
ISU55_14425	COG4149	molybdate abc transporter
ISU55_14430	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISU55_14440	COG2005	Transcriptional regulator
ISU55_14440	COG3585	molybdate ion transport
ISU55_14445	COG1119	ATPase activity
ISU55_14455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISU55_14460	COG1085	galactose-1-phosphate uridylyltransferase
ISU55_14475	COG2017	converts alpha-aldose to the beta-anomer
ISU55_14490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU55_14495	COG1230	cation diffusion facilitator family transporter
ISU55_14525	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISU55_14530	COG2885	chlorophyll binding
ISU55_14540	COG3064	Membrane
ISU55_14540	COG3064	Membrane
ISU55_14545	COG0848	biopolymer transport protein
ISU55_14550	COG0811	peptide transport
ISU55_14555	COG0824	Thioesterase
ISU55_14560	COG3790	cyd operon protein YbgE
ISU55_14565	COG4890	Cyd operon protein YbgT
ISU55_14570	COG1294	oxidase, subunit
ISU55_14575	COG1271	oxidase subunit
ISU55_14580	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISU55_14590	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU55_14595	COG0567	Dehydrogenase, E1 component
ISU55_14605	COG1053	succinate dehydrogenase
ISU55_14610	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISU55_14615	COG2009	succinate dehydrogenase
ISU55_14630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISU55_14635	COG0497	DNA recombination
ISU55_14640	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU55_14650	COG2867	negative regulation of translational initiation
ISU55_14670	COG0582	viral genome integration into host DNA
ISU55_14720	COG3657	addiction module killer protein
ISU55_14745	COG1953	Uracil, thiamine, allantoin
ISU55_14765	COG2226	methyltransferase
ISU55_14770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU55_14775	COG1388	LysM domain
ISU55_14775	COG0741	lytic transglycosylase activity
ISU55_14790	COG0656	L-ascorbic acid biosynthetic process
ISU55_14820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU55_14830	COG2011	ABC-type metal ion transport system permease component
ISU55_14835	COG1464	Belongs to the NlpA lipoprotein family
ISU55_14845	COG1720	tRNA m6t6A37 methyltransferase activity
ISU55_14855	COG3015	lipoprotein NlpE involved in copper resistance
ISU55_14865	COG4681	YaeQ
ISU55_14875	COG4568	rho-dependent transcription termination
ISU55_14885	COG0037	tRNA processing
ISU55_14890	COG0346	lactoylglutathione lyase activity
ISU55_14900	COG0587	DNA-directed DNA polymerase activity
ISU55_14925	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU55_14940	COG0750	zinc metalloprotease
ISU55_14945	COG0575	Belongs to the CDS family
ISU55_15005	COG0564	pseudouridine synthase activity
ISU55_15010	COG3098	single-species biofilm formation
ISU55_15030	COG1611	Belongs to the LOG family
ISU55_15045	COG2363	Small membrane protein
ISU55_15050	COG0583	DNA-binding transcription factor activity
ISU55_15060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISU55_15065	COG2166	iron-sulfur cluster assembly
ISU55_15070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISU55_15075	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISU55_15090	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU55_15100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISU55_15105	COG1074	ATP-dependent DNA helicase activity
ISU55_15130	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISU55_15180	COG0667	Aldo Keto reductase
ISU55_15210	COG1609	Transcriptional regulator
ISU55_15220	COG0583	DNA-binding transcription factor activity
ISU55_15225	COG2814	Major facilitator Superfamily
ISU55_15230	COG0583	DNA-binding transcription factor activity
ISU55_15245	COG0840	transmembrane signaling receptor activity
ISU55_15290	COG2165	general secretion pathway protein
ISU55_15310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU55_15330	COG0288	reversible hydration of carbon dioxide
ISU55_15370	COG3119	arylsulfatase activity
ISU55_15375	COG1349	DNA-binding transcription factor activity
ISU55_15385	COG2222	sugar isomerase
ISU55_15390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU55_15395	COG3715	PTS system
ISU55_15400	COG3716	PTS system mannose fructose sorbose family IID component
ISU55_15405	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU55_15415	COG1028	Short-chain dehydrogenase reductase Sdr
ISU55_15425	COG0641	radical SAM
ISU55_15430	COG3119	arylsulfatase activity
ISU55_15455	COG2271	Major facilitator Superfamily
ISU55_15475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU55_15475	COG1263	PTS System
ISU55_15480	COG1874	Beta-galactosidase
ISU55_15485	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISU55_15490	COG3833	ABC-type maltose transport systems, permease component
ISU55_15495	COG1175	transmembrane transport
ISU55_15500	COG2182	Extracellular solute-binding protein
ISU55_15510	COG1129	ABC transporter
ISU55_15515	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_15520	COG1879	ABC-type sugar transport system periplasmic component
ISU55_15530	COG0791	NLP P60 protein
ISU55_15535	COG1695	Transcriptional regulator
ISU55_15625	COG2944	sequence-specific DNA binding
ISU55_15650	COG0582	viral genome integration into host DNA
ISU55_15670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISU55_15675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU55_15680	COG4974	Belongs to the 'phage' integrase family
ISU55_15685	COG0716	FMN binding
ISU55_15690	COG4452	Inner membrane protein CreD
ISU55_15695	COG2205	protein histidine kinase activity
ISU55_15700	COG0745	RESPONSE REGULATOR receiver
ISU55_15725	COG1272	protein, Hemolysin III
ISU55_15770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU55_15775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU55_15780	COG0006	proline dipeptidase activity
ISU55_15800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISU55_15810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISU55_15845	COG0191	fructose-bisphosphate aldolase activity
ISU55_15880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISU55_15885	COG0501	Belongs to the peptidase M48B family
ISU55_15900	COG1166	arginine decarboxylase activity
ISU55_15915	COG2356	endonuclease I
ISU55_15920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISU55_15925	COG0189	ligase activity
ISU55_15940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU55_15950	COG2805	Type II/IV secretion system protein
ISU55_15955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISU55_15960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISU55_15965	COG0762	integral membrane protein
ISU55_15975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISU55_15980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU55_15985	COG1073	alpha beta
ISU55_15985	COG3064	Membrane
ISU55_15985	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ISU55_16010	COG3171	Protein conserved in bacteria
ISU55_16020	COG1194	a g-specific adenine glycosylase
ISU55_16040	COG4774	siderophore transport
ISU55_16045	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_16050	COG1129	ABC transporter
ISU55_16055	COG1879	ABC-type sugar transport system periplasmic component
ISU55_16060	COG1982	Orn Lys Arg decarboxylase major
ISU55_16175	COG3916	Acyl-homoserine-lactone synthase
ISU55_16180	COG2771	luxR family
ISU55_16230	COG2211	Major facilitator Superfamily
ISU55_16240	COG5001	Diguanylate cyclase
ISU55_16250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU55_16295	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISU55_16300	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU55_16305	COG4771	TonB-dependent receptor
ISU55_16325	COG2226	methyltransferase
ISU55_16325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU55_16325	COG3433	isochorismatase activity
ISU55_16335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU55_16335	COG2226	methyltransferase
ISU55_16335	COG3433	isochorismatase activity
ISU55_16360	COG2375	cellular response to nickel ion
ISU55_16360	COG1132	(ABC) transporter
ISU55_16365	COG1132	(ABC) transporter
ISU55_16380	COG2610	gluconate transmembrane transporter activity
ISU55_16395	COG3501	Rhs element vgr protein
ISU55_16420	COG0471	metal ion transport
ISU55_16445	COG3710	Transcriptional regulator
ISU55_16465	COG1256	bacterial-type flagellum assembly
ISU55_16475	COG1706	bacterial-type flagellum-dependent cell motility
ISU55_16485	COG4786	Flagellar basal body rod
ISU55_16490	COG4787	bacterial-type flagellum-dependent cell motility
ISU55_16495	COG1749	Flagellar hook protein flgE
ISU55_16500	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ISU55_16505	COG1558	bacterial-type flagellum-dependent cell motility
ISU55_16510	COG1815	bacterial-type flagellum-dependent cell motility
ISU55_16515	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ISU55_16555	COG1677	Flagellar hook-basal body complex protein FliE
ISU55_16580	COG1987	bacterial-type flagellum assembly
ISU55_16585	COG1684	flagellar biosynthetic protein fliR
ISU55_16590	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU55_16610	COG4592	Periplasmic binding protein
ISU55_16645	COG4964	Belongs to the GSP D family
ISU55_16650	COG4964	Belongs to the GSP D family
ISU55_16700	COG0848	biopolymer transport protein
ISU55_16705	COG0811	peptide transport
ISU55_16710	COG0626	cystathionine gamma-synthase activity
ISU55_16715	COG0586	Pfam SNARE associated Golgi protein
ISU55_16720	COG2207	Transcriptional regulator
ISU55_16725	COG1979	alcohol dehydrogenase
ISU55_16735	COG0656	L-ascorbic acid biosynthetic process
ISU55_16745	COG2132	Multicopper oxidase
ISU55_16755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISU55_16770	COG0583	DNA-binding transcription factor activity
ISU55_16780	COG3150	esterase
ISU55_16785	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISU55_16790	COG3151	Protein conserved in bacteria
ISU55_16795	COG0494	nUDIX hydrolase
ISU55_16800	COG1538	Outer membrane efflux protein
ISU55_16810	COG0754	glutathionylspermidine amidase activity
ISU55_16815	COG3384	dioxygenase
ISU55_16835	COG0531	amino acid
ISU55_16850	COG3025	triphosphatase activity
ISU55_16855	COG4991	sh3 domain protein
ISU55_16870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISU55_16885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISU55_16890	COG0358	DNA primase activity
ISU55_16970	COG0251	oxidation-reduction process
ISU55_16990	COG0436	Aminotransferase
ISU55_17010	COG1289	transmembrane transporter activity
ISU55_17030	COG0395	ABC-type sugar transport system, permease component
ISU55_17040	COG2182	Extracellular solute-binding protein
ISU55_17045	COG1609	Transcriptional regulator
ISU55_17050	COG3459	Glycosyltransferase 36 associated
ISU55_17055	COG3842	ATPase activity
ISU55_17075	COG3210	domain, Protein
ISU55_17080	COG3210	domain, Protein
ISU55_17110	COG3210	domain, Protein
ISU55_17115	COG2831	hemolysin activation secretion protein
ISU55_17120	COG4245	von Willebrand factor, type A
ISU55_17135	COG4245	von Willebrand factor, type A
ISU55_17150	COG3247	response to pH
ISU55_17155	COG1902	pentaerythritol trinitrate reductase activity
ISU55_17155	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISU55_17170	COG1451	nucleotide metabolic process
ISU55_17175	COG0673	inositol 2-dehydrogenase activity
ISU55_17195	COG2721	sulfolactate sulfo-lyase activity
ISU55_17215	COG2271	Major facilitator Superfamily
ISU55_17230	COG0586	Pfam SNARE associated Golgi protein
ISU55_17245	COG4575	ribosome binding
ISU55_17250	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISU55_17260	COG2259	Doxx family
ISU55_17280	COG0494	nUDIX hydrolase
ISU55_17310	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISU55_17315	COG0849	cell division
ISU55_17320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISU55_17340	COG0772	Belongs to the SEDS family
ISU55_17355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISU55_17360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISU55_17365	COG0768	penicillin binding
ISU55_17370	COG3116	cell division
ISU55_17395	COG1609	Transcriptional regulator
ISU55_17410	COG0028	Belongs to the TPP enzyme family
ISU55_17415	COG1022	Amp-dependent synthetase and ligase
ISU55_17440	COG0473	3-isopropylmalate dehydrogenase activity
ISU55_17455	COG2814	Major facilitator Superfamily
ISU55_17465	COG4143	(ABC) transporter
ISU55_17470	COG1178	ABC-type Fe3 transport system permease component
ISU55_17475	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ISU55_17480	COG0586	Pfam SNARE associated Golgi protein
ISU55_17485	COG0417	DNA replication proofreading
ISU55_17505	COG3047	cAMP biosynthetic process
ISU55_17505	COG2885	chlorophyll binding
ISU55_17590	COG0564	pseudouridine synthase activity
ISU55_17595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISU55_17645	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISU55_17655	COG2966	Psort location CytoplasmicMembrane, score
ISU55_17660	COG1280	lysine exporter protein (LysE YggA)
ISU55_17665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISU55_17690	COG1047	Peptidyl-prolyl cis-trans
ISU55_17705	COG0196	riboflavin kinase activity
ISU55_17715	COG0583	DNA-binding transcription factor activity
ISU55_17735	COG1584	GPR1 FUN34 yaaH family protein
ISU55_17750	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISU55_17790	COG0745	RESPONSE REGULATOR receiver
ISU55_17795	COG3045	CreA protein
ISU55_17800	COG3708	Transcriptional regulator
ISU55_17800	COG2207	Transcriptional regulator
ISU55_17815	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ISU55_17820	COG0741	lytic transglycosylase activity
ISU55_17835	COG2199	diguanylate cyclase activity
ISU55_17840	COG2885	chlorophyll binding
ISU55_17865	COG0560	Phosphoserine phosphatase
ISU55_17870	COG3726	membrane protein affecting hemolysin expression
ISU55_17895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU55_17900	COG0084	hydrolase, TatD family'
ISU55_17905	COG4667	esterase of the alpha-beta hydrolase superfamily
ISU55_17915	COG2823	Periplasmic or secreted lipoprotein
ISU55_17925	COG0456	acetyltransferase
ISU55_17930	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISU55_17970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU55_17975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU55_17990	COG0859	PFAM glycosyl transferase family 9
ISU55_17995	COG1070	Carbohydrate kinase
ISU55_18045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU55_18045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU55_18045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU55_18050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU55_18055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU55_18060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU55_18065	COG2207	Transcriptional regulator
ISU55_18075	COG4269	membrane
ISU55_18130	COG1401	restriction endodeoxyribonuclease activity
ISU55_18155	COG1011	Hydrolase
ISU55_18165	COG0174	glutamine synthetase
ISU55_18170	COG3852	Histidine kinase
ISU55_18180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU55_18205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU55_18205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU55_18210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU55_18215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISU55_18220	COG3084	Protein conserved in bacteria
ISU55_18230	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISU55_18235	COG3328	transposase activity
ISU55_18295	COG0678	peroxiredoxin activity
ISU55_18295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU55_18300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU55_18325	COG1629	transport
ISU55_18340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISU55_18375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU55_18380	COG0058	SHG alpha-glucan phosphorylase activity
ISU55_18405	COG3275	phosphorelay sensor kinase activity
ISU55_18440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU55_18445	COG2095	MarC family integral membrane protein
ISU55_18460	COG3265	gluconokinase activity
ISU55_18465	COG2610	gluconate transmembrane transporter activity
ISU55_18470	COG1609	Transcriptional regulator
ISU55_18475	COG1741	Belongs to the pirin family
ISU55_18495	COG0191	fructose-bisphosphate aldolase activity
ISU55_18510	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU55_18525	COG2081	HI0933 family
ISU55_18530	COG0306	phosphate transporter
ISU55_18545	COG0589	response to stress
ISU55_18565	COG0339	signal peptide processing
ISU55_18570	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISU55_18575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU55_18580	COG3835	regulator
ISU55_18590	COG2610	gluconate transmembrane transporter activity
ISU55_18595	COG1929	Belongs to the glycerate kinase type-1 family
ISU55_18620	COG1295	ribonuclease BN
ISU55_18625	COG2134	cdp-diacylglycerol pyrophosphatase
ISU55_18630	COG2982	Protein involved in outer membrane biogenesis
ISU55_18635	COG2200	EAL domain
ISU55_18640	COG1942	4-Oxalocrotonate Tautomerase
ISU55_18645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU55_18650	COG0612	Peptidase, M16
ISU55_18670	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU55_18675	COG2200	EAL domain
ISU55_18675	COG2199	diguanylate cyclase activity
ISU55_18680	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISU55_18685	COG4608	Belongs to the ABC transporter superfamily
ISU55_18690	COG0444	Belongs to the ABC transporter superfamily
ISU55_18695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU55_18700	COG0601	transmembrane transport
ISU55_18705	COG0747	negative chemotaxis
ISU55_18710	COG2831	hemolysin activation secretion protein
ISU55_18725	COG2271	Major facilitator Superfamily
ISU55_18745	COG0456	acetyltransferase
ISU55_18750	COG2982	Protein involved in outer membrane biogenesis
ISU55_18755	COG2233	PERMEase
ISU55_18760	COG0786	glutamate:sodium symporter activity
ISU55_18770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISU55_18775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU55_18780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU55_18800	COG2860	membrane
ISU55_18805	COG1561	YicC-like family, N-terminal region
ISU55_18830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISU55_18865	COG1519	Transferase
ISU55_18870	COG0859	PFAM glycosyl transferase family 9
ISU55_18875	COG0859	PFAM glycosyl transferase family 9
ISU55_18885	COG0156	8-amino-7-oxononanoate synthase activity
ISU55_18900	COG4942	peptidase
ISU55_18910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU55_18915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU55_18930	COG1045	serine acetyltransferase
ISU55_18935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISU55_18940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU55_18940	COG2169	Transcriptional regulator
ISU55_18945	COG2205	protein histidine kinase activity
ISU55_18950	COG0745	RESPONSE REGULATOR receiver
ISU55_18955	COG3678	ATP-independent chaperone mediated protein folding
ISU55_18980	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISU55_18990	COG0471	metal ion transport
ISU55_18995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISU55_19010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISU55_19015	COG0583	DNA-binding transcription factor activity
ISU55_19030	COG3152	Membrane
ISU55_19040	COG1494	fructose-1,6-bisphosphatase
ISU55_19045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU55_19050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISU55_19090	COG1575	Belongs to the MenA family. Type 1 subfamily
ISU55_19105	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU55_19110	COG1609	Transcriptional regulator
ISU55_19115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISU55_19125	COG4682	membrane
ISU55_19140	COG0527	aspartate kinase activity
ISU55_19140	COG0460	homoserine dehydrogenase
ISU55_19155	COG1349	DNA-binding transcription factor activity
ISU55_19175	COG0058	SHG alpha-glucan phosphorylase activity
ISU55_19180	COG0058	SHG alpha-glucan phosphorylase activity
ISU55_19185	COG1640	4-alpha-glucanotransferase
ISU55_19220	COG1918	ferrous iron import across plasma membrane
ISU55_19225	COG2183	response to ionizing radiation
ISU55_19230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU55_19255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISU55_19260	COG1011	Hydrolase
ISU55_19270	COG0494	nUDIX hydrolase
ISU55_19275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISU55_19300	COG4796	Type ii and iii secretion system protein
ISU55_19325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISU55_19330	COG0546	phosphoglycolate phosphatase activity
ISU55_19335	COG0180	Tryptophanyl-tRNA synthetase
ISU55_19355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISU55_19360	COG0402	S-adenosylhomocysteine deaminase activity
ISU55_19400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU55_19405	COG0433	COG0433 Predicted ATPase
ISU55_19420	COG1289	transmembrane transporter activity
ISU55_19430	COG1765	OsmC-like protein
ISU55_19440	COG3954	Phosphoribulokinase
ISU55_19450	COG0429	hydrolase of the alpha beta-hydrolase fold
ISU55_19460	COG4521	taurine ABC transporter
ISU55_19470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU55_19475	COG2175	clavaminate synthase activity
ISU55_19485	COG1216	Glycosyl transferase, family 2
ISU55_19505	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISU55_19510	COG1047	Peptidyl-prolyl cis-trans
ISU55_19520	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU55_19525	COG2964	Protein conserved in bacteria
ISU55_19545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ISU55_19550	COG0049	tRNA binding
ISU55_19580	COG0051	transcription antitermination factor activity, RNA binding
ISU55_19595	COG0089	rRNA binding
ISU55_19605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISU55_19615	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISU55_19620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISU55_19630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISU55_19635	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ISU55_19675	COG1841	ribosomal large subunit assembly
ISU55_19685	COG0201	protein transport
ISU55_19690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU55_19705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISU55_19720	COG0789	Transcriptional regulator
ISU55_19725	COG3036	rescue of stalled ribosome
ISU55_19755	COG0758	DNA mediated transformation
ISU55_19765	COG0551	DNA topoisomerase type I activity
ISU55_19780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISU55_19800	COG2197	response regulator
ISU55_19805	COG2194	sulfuric ester hydrolase activity
ISU55_19820	COG2986	histidine ammonia-lyase
ISU55_19850	COG4607	ABC-type enterochelin transport system periplasmic component
ISU55_19860	COG4605	iron ion homeostasis
ISU55_19865	COG4604	ABC transporter, ATP-binding protein
ISU55_19910	COG0582	viral genome integration into host DNA
ISU55_19920	COG1609	Transcriptional regulator
ISU55_19920	COG2207	Transcriptional regulator
ISU55_19925	COG4214	carbohydrate transport
ISU55_19935	COG4213	ABC transporter substrate-binding protein
ISU55_19945	COG1070	Carbohydrate kinase
ISU55_19955	COG3121	Chaperone
ISU55_19970	COG3274	enterobacterial common antigen metabolic process
ISU55_20055	COG1175	transmembrane transport
ISU55_20060	COG3833	ABC-type maltose transport systems, permease component
ISU55_20075	COG0527	aspartate kinase activity
ISU55_20105	COG2224	Isocitrate lyase
ISU55_20110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISU55_20150	COG2186	Transcriptional regulator
ISU55_20155	COG0477	Major facilitator Superfamily
ISU55_20170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU55_20200	COG1522	sequence-specific DNA binding
ISU55_20205	COG0716	FMN binding
ISU55_20220	COG3312	ion transport
ISU55_20275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISU55_20280	COG0573	inorganic phosphate transmembrane transporter activity
ISU55_20285	COG0581	inorganic phosphate transmembrane transporter activity
ISU55_20295	COG0704	Plays a role in the regulation of phosphate uptake
ISU55_20305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU55_20310	COG0765	amino acid transport
ISU55_20315	COG0765	amino acid transport
ISU55_20320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU55_20330	COG2252	PERMEase
ISU55_20360	COG0706	membrane insertase activity
ISU55_20375	COG0230	Belongs to the bacterial ribosomal protein bL34 family