locus-tag	class	description
YPD4_0001	COG0716	FMN binding
YPD4_0002	COG1522	sequence-specific DNA binding
YPD4_0008	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD4_0009	COG0477	Major facilitator Superfamily
YPD4_0010	COG2186	Transcriptional regulator
YPD4_0011	COG3328	transposase activity
YPD4_0012	COG1763	Mo-molybdopterin cofactor biosynthetic process
YPD4_0014	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
YPD4_0015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YPD4_0016	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPD4_0016	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPD4_0017	COG1943	Transposase
YPD4_0020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YPD4_0022	COG3852	Histidine kinase
YPD4_0023	COG0174	glutamine synthetase
YPD4_0025	COG1011	Hydrolase
YPD4_0026	COG1295	ribonuclease BN
YPD4_0030	COG0456	acetyltransferase
YPD4_0031	COG2982	Protein involved in outer membrane biogenesis
YPD4_0032	COG2233	PERMEase
YPD4_0033	COG2233	PERMEase
YPD4_0034	COG0786	glutamate:sodium symporter activity
YPD4_0035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YPD4_0036	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPD4_0037	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YPD4_0039	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YPD4_0040	COG2860	membrane
YPD4_0041	COG1561	YicC-like family, N-terminal region
YPD4_0046	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YPD4_0051	COG1519	Transferase
YPD4_0052	COG0859	PFAM glycosyl transferase family 9
YPD4_0053	COG0859	PFAM glycosyl transferase family 9
YPD4_0055	COG0156	8-amino-7-oxononanoate synthase activity
YPD4_0057	COG2861	carbohydrate metabolic process
YPD4_0058	COG2861	carbohydrate metabolic process
YPD4_0059	COG4942	peptidase
YPD4_0061	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YPD4_0064	COG1045	serine acetyltransferase
YPD4_0065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
YPD4_0066	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YPD4_0066	COG2169	Transcriptional regulator
YPD4_0067	COG2205	protein histidine kinase activity
YPD4_0068	COG0745	RESPONSE REGULATOR receiver
YPD4_0069	COG3678	ATP-independent chaperone mediated protein folding
YPD4_0073	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
YPD4_0075	COG0471	metal ion transport
YPD4_0076	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YPD4_0077	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YPD4_0078	COG0583	DNA-binding transcription factor activity
YPD4_0081	COG3152	Membrane
YPD4_0083	COG1494	fructose-1,6-bisphosphatase
YPD4_0084	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YPD4_0085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YPD4_0091	COG1575	Belongs to the MenA family. Type 1 subfamily
YPD4_0094	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YPD4_0095	COG1609	Transcriptional regulator
YPD4_0096	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YPD4_0097	COG4682	membrane
YPD4_0099	COG0626	cystathionine gamma-synthase activity
YPD4_0100	COG0460	homoserine dehydrogenase
YPD4_0100	COG0527	aspartate kinase activity
YPD4_0102	COG2801	Transposase and inactivated derivatives
YPD4_0104	COG1349	DNA-binding transcription factor activity
YPD4_0106	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YPD4_0108	COG0058	SHG alpha-glucan phosphorylase activity
YPD4_0109	COG0058	SHG alpha-glucan phosphorylase activity
YPD4_0110	COG1640	4-alpha-glucanotransferase
YPD4_0115	COG2183	response to ionizing radiation
YPD4_0116	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPD4_0117	COG0745	RESPONSE REGULATOR receiver
YPD4_0121	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
YPD4_0122	COG1011	Hydrolase
YPD4_0124	COG0494	nUDIX hydrolase
YPD4_0125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
YPD4_0130	COG4796	Type ii and iii secretion system protein
YPD4_0131	COG4796	Type ii and iii secretion system protein
YPD4_0136	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
YPD4_0137	COG0546	phosphoglycolate phosphatase activity
YPD4_0138	COG0180	Tryptophanyl-tRNA synthetase
YPD4_0141	COG2146	nitrite reductase [NAD(P)H] activity
YPD4_0142	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YPD4_0143	COG0402	S-adenosylhomocysteine deaminase activity
YPD4_0147	COG1486	melibiose metabolic process
YPD4_0148	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YPD4_0149	COG0433	COG0433 Predicted ATPase
YPD4_0152	COG1289	transmembrane transporter activity
YPD4_0154	COG1765	OsmC-like protein
YPD4_0156	COG3954	Phosphoribulokinase
YPD4_0157	COG0429	hydrolase of the alpha beta-hydrolase fold
YPD4_0159	COG4521	taurine ABC transporter
YPD4_0161	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPD4_0162	COG2175	clavaminate synthase activity
YPD4_0164	COG1216	Glycosyl transferase, family 2
YPD4_0165	COG0488	(ABC) transporter
YPD4_0166	COG0488	(ABC) transporter
YPD4_0167	COG2249	NAD(P)H dehydrogenase (quinone) activity
YPD4_0169	COG1047	Peptidyl-prolyl cis-trans
YPD4_0170	COG0545	Peptidyl-prolyl cis-trans isomerase
YPD4_0171	COG2964	Protein conserved in bacteria
YPD4_0174	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
YPD4_0175	COG0049	tRNA binding
YPD4_0178	COG1943	Transposase
YPD4_0180	COG0051	transcription antitermination factor activity, RNA binding
YPD4_0186	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YPD4_0187	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YPD4_0188	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YPD4_0200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YPD4_0203	COG0789	Transcriptional regulator
YPD4_0205	COG0569	domain protein
YPD4_0209	COG0758	DNA mediated transformation
YPD4_0211	COG0551	DNA topoisomerase type I activity
YPD4_0214	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YPD4_0219	COG3162	membrane
YPD4_0221	COG1301	dicarboxylic acid transport
YPD4_0239	COG2391	methyltransferase activity
YPD4_0240	COG0583	DNA-binding transcription factor activity
YPD4_0241	COG0814	amino acid
YPD4_0242	COG0626	cystathionine gamma-synthase activity
YPD4_0244	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD4_0245	COG4558	Periplasmic binding protein
YPD4_0246	COG3720	iron ion transport
YPD4_0247	COG4771	TonB-dependent receptor
YPD4_0248	COG4771	TonB-dependent receptor
YPD4_0249	COG0702	epimerase
YPD4_0250	COG3721	Heme iron utilization protein
YPD4_0255	COG1358	cellular component organization or biogenesis
YPD4_0268	COG3121	Chaperone
YPD4_0275	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
YPD4_0277	COG0735	belongs to the Fur family
YPD4_0278	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPD4_0280	COG0305	Participates in initiation and elongation during chromosome replication
YPD4_0281	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YPD4_0282	COG1448	Aminotransferase
YPD4_0283	COG2315	Protein conserved in bacteria
YPD4_0284	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YPD4_0285	COG0629	single-stranded DNA binding
YPD4_0287	COG1454	alcohol dehydrogenase
YPD4_0296	COG1309	transcriptional regulator
YPD4_0297	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPD4_0297	COG0493	'glutamate synthase
YPD4_0298	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPD4_0299	COG3383	formate dehydrogenase (NAD+) activity
YPD4_0301	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPD4_0308	COG2076	Multidrug Resistance protein
YPD4_0309	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
YPD4_0311	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
YPD4_0312	COG1053	succinate dehydrogenase
YPD4_0314	COG1511	domain protein
YPD4_0314	COG3264	Mechanosensitive ion channel
YPD4_0317	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
YPD4_0318	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
YPD4_0319	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
YPD4_0319	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YPD4_0320	COG0802	atpase or kinase
YPD4_0321	COG0860	N-Acetylmuramoyl-L-alanine amidase
YPD4_0325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YPD4_0326	COG0330	HflC and HflK could
YPD4_0327	COG0330	HflC and HflK could
YPD4_0330	COG0557	exoribonuclease II activity
YPD4_0331	COG0557	exoribonuclease II activity
YPD4_0332	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPD4_0333	COG1960	acyl-CoA dehydrogenase activity
YPD4_0334	COG3650	response to hydrogen peroxide
YPD4_0337	COG1401	restriction endodeoxyribonuclease activity
YPD4_0345	COG4269	membrane
YPD4_0347	COG2207	Transcriptional regulator
YPD4_0348	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD4_0349	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD4_0350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD4_0351	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YPD4_0351	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD4_0351	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD4_0358	COG2390	Transcriptional regulator
YPD4_0360	COG0859	PFAM glycosyl transferase family 9
YPD4_0362	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD4_0363	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPD4_0365	COG3706	GGDEF domain
YPD4_0368	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
YPD4_0369	COG0456	acetyltransferase
YPD4_0371	COG2823	Periplasmic or secreted lipoprotein
YPD4_0372	COG4667	esterase of the alpha-beta hydrolase superfamily
YPD4_0373	COG0084	hydrolase, TatD family'
YPD4_0374	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YPD4_0375	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YPD4_0380	COG3726	membrane protein affecting hemolysin expression
YPD4_0381	COG0560	Phosphoserine phosphatase
YPD4_0385	COG0488	(ABC) transporter
YPD4_0386	COG0488	(ABC) transporter
YPD4_0387	COG2885	chlorophyll binding
YPD4_0388	COG2199	diguanylate cyclase activity
YPD4_0391	COG0741	lytic transglycosylase activity
YPD4_0392	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
YPD4_0395	COG3708	Transcriptional regulator
YPD4_0395	COG2207	Transcriptional regulator
YPD4_0396	COG3045	CreA protein
YPD4_0397	COG0745	RESPONSE REGULATOR receiver
YPD4_0404	COG0521	Mo-molybdopterin cofactor biosynthetic process
YPD4_0407	COG1584	GPR1 FUN34 yaaH family protein
YPD4_0411	COG0583	DNA-binding transcription factor activity
YPD4_0412	COG0196	riboflavin kinase activity
YPD4_0415	COG1047	Peptidyl-prolyl cis-trans
YPD4_0417	COG1943	Transposase
YPD4_0419	COG0505	Belongs to the CarA family
YPD4_0420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
YPD4_0421	COG1280	lysine exporter protein (LysE YggA)
YPD4_0422	COG2966	Psort location CytoplasmicMembrane, score
YPD4_0424	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
YPD4_0425	COG1943	Transposase
YPD4_0430	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
YPD4_0431	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YPD4_0433	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
YPD4_0434	COG0564	pseudouridine synthase activity
YPD4_0444	COG3501	Rhs element vgr protein
YPD4_0452	COG2885	chlorophyll binding
YPD4_0452	COG3047	cAMP biosynthetic process
YPD4_0456	COG0417	DNA replication proofreading
YPD4_0457	COG0586	Pfam SNARE associated Golgi protein
YPD4_0459	COG1178	ABC-type Fe3 transport system permease component
YPD4_0460	COG4143	(ABC) transporter
YPD4_0462	COG2814	Major facilitator Superfamily
YPD4_0467	COG0473	3-isopropylmalate dehydrogenase activity
YPD4_0470	COG1022	Amp-dependent synthetase and ligase
YPD4_0471	COG0028	Belongs to the TPP enzyme family
YPD4_0473	COG1943	Transposase
YPD4_0474	COG1609	Transcriptional regulator
YPD4_0478	COG3116	cell division
YPD4_0479	COG0768	penicillin binding
YPD4_0480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YPD4_0481	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YPD4_0484	COG0772	Belongs to the SEDS family
YPD4_0488	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
YPD4_0489	COG0849	cell division
YPD4_0490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
YPD4_0495	COG0494	nUDIX hydrolase
YPD4_0498	COG2259	Doxx family
YPD4_0499	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
YPD4_0500	COG4575	ribosome binding
YPD4_0503	COG0586	Pfam SNARE associated Golgi protein
YPD4_0506	COG2271	Major facilitator Superfamily
YPD4_0508	COG0246	Mannitol dehydrogenase
YPD4_0509	COG2721	sulfolactate sulfo-lyase activity
YPD4_0513	COG0673	inositol 2-dehydrogenase activity
YPD4_0514	COG1451	nucleotide metabolic process
YPD4_0517	COG0446	pyridine nucleotide-disulphide oxidoreductase
YPD4_0517	COG1902	pentaerythritol trinitrate reductase activity
YPD4_0518	COG3247	response to pH
YPD4_0521	COG4245	von Willebrand factor, type A
YPD4_0524	COG4245	von Willebrand factor, type A
YPD4_0525	COG2831	hemolysin activation secretion protein
YPD4_0526	COG3210	domain, Protein
YPD4_0527	COG3210	domain, Protein
YPD4_0531	COG3842	ATPase activity
YPD4_0532	COG3459	Glycosyltransferase 36 associated
YPD4_0533	COG1609	Transcriptional regulator
YPD4_0534	COG1653	transport
YPD4_0536	COG0395	ABC-type sugar transport system, permease component
YPD4_0540	COG1289	transmembrane transporter activity
YPD4_0546	COG0251	oxidation-reduction process
YPD4_0555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YPD4_0556	COG0358	DNA primase activity
YPD4_0557	COG0358	DNA primase activity
YPD4_0560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
YPD4_0564	COG4991	sh3 domain protein
YPD4_0565	COG3025	triphosphatase activity
YPD4_0568	COG0531	amino acid
YPD4_0570	COG3384	dioxygenase
YPD4_0571	COG0754	glutathionylspermidine amidase activity
YPD4_0572	COG0754	glutathionylspermidine amidase activity
YPD4_0574	COG1538	Outer membrane efflux protein
YPD4_0575	COG0494	nUDIX hydrolase
YPD4_0576	COG3151	Protein conserved in bacteria
YPD4_0577	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YPD4_0578	COG3150	esterase
YPD4_0579	COG0187	DNA topoisomerase II activity
YPD4_0580	COG0583	DNA-binding transcription factor activity
YPD4_0581	COG2249	NAD(P)H dehydrogenase (quinone) activity
YPD4_0582	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YPD4_0583	COG0204	Acyl-transferase
YPD4_0584	COG2132	Multicopper oxidase
YPD4_0587	COG0656	L-ascorbic acid biosynthetic process
YPD4_0588	COG1979	alcohol dehydrogenase
YPD4_0589	COG2207	Transcriptional regulator
YPD4_0590	COG0586	Pfam SNARE associated Golgi protein
YPD4_0591	COG0626	cystathionine gamma-synthase activity
YPD4_0592	COG0811	peptide transport
YPD4_0593	COG0848	biopolymer transport protein
YPD4_0602	COG4964	Belongs to the GSP D family
YPD4_0603	COG4964	Belongs to the GSP D family
YPD4_0606	COG1943	Transposase
YPD4_0607	COG1943	Transposase
YPD4_0611	COG4592	Periplasmic binding protein
YPD4_0615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPD4_0616	COG1684	flagellar biosynthetic protein fliR
YPD4_0620	COG2204	response regulator
YPD4_0628	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
YPD4_0629	COG1815	bacterial-type flagellum-dependent cell motility
YPD4_0630	COG1558	bacterial-type flagellum-dependent cell motility
YPD4_0631	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
YPD4_0632	COG1749	Flagellar hook protein flgE
YPD4_0635	COG4786	Flagellar basal body rod
YPD4_0636	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
YPD4_0637	COG1706	bacterial-type flagellum-dependent cell motility
YPD4_0638	COG1256	bacterial-type flagellum assembly
YPD4_0642	COG3710	Transcriptional regulator
YPD4_0646	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
YPD4_0651	COG1191	sigma factor activity
YPD4_0652	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
YPD4_0657	COG2801	Transposase and inactivated derivatives
YPD4_0659	COG1609	Transcriptional regulator
YPD4_0660	COG0471	metal ion transport
YPD4_0662	COG3209	COG3209 Rhs family protein
YPD4_0664	COG3501	Rhs element vgr protein
YPD4_0669	COG2610	gluconate transmembrane transporter activity
YPD4_0672	COG1132	(ABC) transporter
YPD4_0678	COG2226	methyltransferase
YPD4_0678	COG3433	isochorismatase activity
YPD4_0678	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPD4_0679	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPD4_0680	COG3433	isochorismatase activity
YPD4_0680	COG2226	methyltransferase
YPD4_0680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPD4_0684	COG4771	TonB-dependent receptor
YPD4_0685	COG2195	Cleaves the N-terminal amino acid of tripeptides
YPD4_0686	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
YPD4_0694	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD4_0695	COG5001	Diguanylate cyclase
YPD4_0695	COG3300	MHYT domain
YPD4_0696	COG2801	Transposase and inactivated derivatives
YPD4_0698	COG2211	Major facilitator Superfamily
YPD4_0708	COG2771	luxR family
YPD4_0709	COG3916	Acyl-homoserine-lactone synthase
YPD4_0723	COG1662	PFAM IS1 transposase
YPD4_0725	COG1982	Orn Lys Arg decarboxylase major
YPD4_0726	COG1879	ABC-type sugar transport system periplasmic component
YPD4_0727	COG1129	ABC transporter
YPD4_0728	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_0729	COG4774	siderophore transport
YPD4_0732	COG1194	a g-specific adenine glycosylase
YPD4_0734	COG3171	Protein conserved in bacteria
YPD4_0735	COG2066	Belongs to the glutaminase family
YPD4_0737	COG3064	Membrane
YPD4_0737	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
YPD4_0737	COG1073	alpha beta
YPD4_0738	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YPD4_0739	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
YPD4_0741	COG0762	integral membrane protein
YPD4_0742	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
YPD4_0743	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
YPD4_0744	COG2805	Type II/IV secretion system protein
YPD4_0746	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPD4_0749	COG0189	ligase activity
YPD4_0750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
YPD4_0751	COG2356	endonuclease I
YPD4_0754	COG1166	arginine decarboxylase activity
YPD4_0756	COG0501	Belongs to the peptidase M48B family
YPD4_0757	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
YPD4_0761	COG0191	fructose-bisphosphate aldolase activity
YPD4_0766	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YPD4_0767	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YPD4_0768	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YPD4_0771	COG0006	proline dipeptidase activity
YPD4_0772	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPD4_0773	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPD4_0778	COG5295	Hep Hag repeat protein
YPD4_0778	COG5295	Hep Hag repeat protein
YPD4_0780	COG1272	protein, Hemolysin III
YPD4_0784	COG0745	RESPONSE REGULATOR receiver
YPD4_0785	COG2205	protein histidine kinase activity
YPD4_0786	COG4452	Inner membrane protein CreD
YPD4_0787	COG0716	FMN binding
YPD4_0788	COG4974	Belongs to the 'phage' integrase family
YPD4_0789	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YPD4_0790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
YPD4_0793	COG0582	viral genome integration into host DNA
YPD4_0795	COG2944	sequence-specific DNA binding
YPD4_0807	COG1695	Transcriptional regulator
YPD4_0808	COG0791	NLP P60 protein
YPD4_0810	COG1879	ABC-type sugar transport system periplasmic component
YPD4_0811	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_0812	COG1129	ABC transporter
YPD4_0814	COG2182	Extracellular solute-binding protein
YPD4_0815	COG1175	transmembrane transport
YPD4_0816	COG3833	ABC-type maltose transport systems, permease component
YPD4_0817	COG3867	Arabinogalactan endo-beta-1,4-galactanase
YPD4_0818	COG1874	Beta-galactosidase
YPD4_0819	COG1263	PTS System
YPD4_0819	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD4_0823	COG2271	Major facilitator Superfamily
YPD4_0826	COG0191	fructose-bisphosphate aldolase activity
YPD4_0828	COG3119	arylsulfatase activity
YPD4_0829	COG0641	radical SAM
YPD4_0831	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_0833	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD4_0834	COG3716	PTS system mannose fructose sorbose family IID component
YPD4_0835	COG3715	PTS system
YPD4_0836	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD4_0837	COG2222	sugar isomerase
YPD4_0839	COG1349	DNA-binding transcription factor activity
YPD4_0840	COG3119	arylsulfatase activity
YPD4_0841	COG1943	Transposase
YPD4_0847	COG0288	reversible hydration of carbon dioxide
YPD4_0861	COG0840	transmembrane signaling receptor activity
YPD4_0864	COG0583	DNA-binding transcription factor activity
YPD4_0865	COG2814	Major facilitator Superfamily
YPD4_0866	COG0583	DNA-binding transcription factor activity
YPD4_0867	COG0019	diaminopimelate decarboxylase activity
YPD4_0868	COG1609	Transcriptional regulator
YPD4_0872	COG0667	Aldo Keto reductase
YPD4_0883	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
YPD4_0885	COG1074	ATP-dependent DNA helicase activity
YPD4_0886	COG1074	ATP-dependent DNA helicase activity
YPD4_0887	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
YPD4_0889	COG0860	N-Acetylmuramoyl-L-alanine amidase
YPD4_0890	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
YPD4_0891	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
YPD4_0892	COG2166	iron-sulfur cluster assembly
YPD4_0893	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YPD4_0894	COG0583	DNA-binding transcription factor activity
YPD4_0895	COG2363	Small membrane protein
YPD4_0897	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPD4_0898	COG1611	Belongs to the LOG family
YPD4_0901	COG1943	Transposase
YPD4_0902	COG3098	single-species biofilm formation
YPD4_0903	COG0564	pseudouridine synthase activity
YPD4_0908	COG0024	Methionine aminopeptidase
YPD4_0915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
YPD4_0916	COG0575	Belongs to the CDS family
YPD4_0917	COG0750	zinc metalloprotease
YPD4_0920	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
YPD4_0924	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YPD4_0926	COG0587	DNA-directed DNA polymerase activity
YPD4_0928	COG0346	lactoylglutathione lyase activity
YPD4_0929	COG0037	tRNA processing
YPD4_0931	COG4681	YaeQ
YPD4_0933	COG3015	lipoprotein NlpE involved in copper resistance
YPD4_0935	COG1720	tRNA m6t6A37 methyltransferase activity
YPD4_0936	COG1464	Belongs to the NlpA lipoprotein family
YPD4_0937	COG2011	ABC-type metal ion transport system permease component
YPD4_0939	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YPD4_0940	COG0656	L-ascorbic acid biosynthetic process
YPD4_0943	COG0741	lytic transglycosylase activity
YPD4_0943	COG1388	LysM domain
YPD4_0945	COG2226	methyltransferase
YPD4_0947	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YPD4_0948	COG1953	Uracil, thiamine, allantoin
YPD4_0956	COG0582	viral genome integration into host DNA
YPD4_0959	COG2867	negative regulation of translational initiation
YPD4_0960	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPD4_0961	COG0497	DNA recombination
YPD4_0962	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YPD4_0965	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
YPD4_0966	COG1053	succinate dehydrogenase
YPD4_0968	COG0567	Dehydrogenase, E1 component
YPD4_0969	COG0508	dehydrogenase complex catalyzes the overall conversion of
YPD4_0971	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
YPD4_0972	COG1271	oxidase subunit
YPD4_0973	COG1294	oxidase, subunit
YPD4_0974	COG0811	peptide transport
YPD4_0975	COG0848	biopolymer transport protein
YPD4_0976	COG3064	Membrane
YPD4_0976	COG3064	Membrane
YPD4_0978	COG2885	chlorophyll binding
YPD4_0979	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
YPD4_0982	COG1230	cation diffusion facilitator family transporter
YPD4_0983	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YPD4_0988	COG2017	converts alpha-aldose to the beta-anomer
YPD4_0990	COG1085	galactose-1-phosphate uridylyltransferase
YPD4_0991	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YPD4_0993	COG1119	ATPase activity
YPD4_0994	COG2005	Transcriptional regulator
YPD4_0994	COG3585	molybdate ion transport
YPD4_0995	COG0725	ABC transporter, periplasmic molybdate-binding protein
YPD4_0996	COG4149	molybdate abc transporter
YPD4_0998	COG0561	phosphatase activity
YPD4_1001	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
YPD4_1004	COG2226	methyltransferase
YPD4_1005	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YPD4_1007	COG0556	nucleotide-excision repair
YPD4_1008	COG0391	Required for morphogenesis under gluconeogenic growth conditions
YPD4_1009	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YPD4_1011	COG0314	molybdopterin synthase activity
YPD4_1012	COG0670	Belongs to the BI1 family
YPD4_1013	COG1943	Transposase
YPD4_1017	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YPD4_1018	COG0583	DNA-binding transcription factor activity
YPD4_1020	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
YPD4_1021	COG2211	Major facilitator Superfamily
YPD4_1022	COG1943	Transposase
YPD4_1023	COG2211	Major facilitator Superfamily
YPD4_1027	COG1902	pentaerythritol trinitrate reductase activity
YPD4_1030	COG0842	Transport permease protein
YPD4_1031	COG0842	Transport permease protein
YPD4_1032	COG1131	(ABC) transporter
YPD4_1034	COG1309	transcriptional regulator
YPD4_1035	COG0513	Belongs to the DEAD box helicase family
YPD4_1038	COG3328	transposase activity
YPD4_1039	COG3328	transposase activity
YPD4_1041	COG0513	Belongs to the DEAD box helicase family
YPD4_1044	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPD4_1045	COG1686	Belongs to the peptidase S11 family
YPD4_1046	COG0277	FAD linked oxidase domain protein
YPD4_1048	COG1403	HNH endonuclease
YPD4_1051	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
YPD4_1054	COG4807	Protein conserved in bacteria
YPD4_1058	COG1122	ATPase activity
YPD4_1059	COG0410	ABC transporter
YPD4_1062	COG2897	thiosulfate sulfurtransferase activity
YPD4_1063	COG1732	Glycine betaine
YPD4_1064	COG1732	Glycine betaine
YPD4_1065	COG1174	glycine betaine transport
YPD4_1066	COG1125	glycine betaine transport
YPD4_1067	COG1174	glycine betaine transport
YPD4_1068	COG0531	amino acid
YPD4_1069	COG1982	Orn Lys Arg decarboxylase major
YPD4_1070	COG0697	spore germination
YPD4_1075	COG0814	amino acid
YPD4_1082	COG0784	Response regulator, receiver
YPD4_1082	COG2205	protein histidine kinase activity
YPD4_1084	COG0642	Histidine kinase
YPD4_1084	COG2198	Histidine kinase
YPD4_1085	COG2198	Histidine kinase
YPD4_1085	COG0642	Histidine kinase
YPD4_1086	COG2223	nitrite transmembrane transporter activity
YPD4_1087	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
YPD4_1089	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
YPD4_1096	COG3395	kinase activity
YPD4_1097	COG0235	Class ii aldolase
YPD4_1098	COG1349	DNA-binding transcription factor activity
YPD4_1099	COG3622	Belongs to the hyi family
YPD4_1101	COG4386	tail sheath protein
YPD4_1108	COG3299	homolog of phage Mu protein gp47
YPD4_1111	COG1737	Transcriptional regulator
YPD4_1112	COG2723	6-phospho-beta-galactosidase activity
YPD4_1115	COG3157	Type VI secretion system effector, Hcp
YPD4_1117	COG3083	sulfuric ester hydrolase activity
YPD4_1119	COG1943	Transposase
YPD4_1120	COG1061	Type III restriction enzyme res subunit
YPD4_1121	COG1187	pseudouridine synthase activity
YPD4_1122	COG2814	Major facilitator Superfamily
YPD4_1124	COG4172	Belongs to the ABC transporter superfamily
YPD4_1125	COG4239	(ABC) transporter, permease
YPD4_1126	COG4174	ABC transporter (Permease)
YPD4_1127	COG4166	transmembrane transport
YPD4_1128	COG2200	EAL domain
YPD4_1129	COG0791	NLP P60 protein
YPD4_1130	COG0671	phosphoesterase, PA-phosphatase related
YPD4_1131	COG0523	cobalamin synthesis protein
YPD4_1132	COG2186	Transcriptional regulator
YPD4_1133	COG0246	Mannitol dehydrogenase
YPD4_1134	COG1312	Catalyzes the dehydration of D-mannonate
YPD4_1137	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_1142	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YPD4_1144	COG1129	ABC transporter
YPD4_1145	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_1146	COG0494	nUDIX hydrolase
YPD4_1148	COG1105	Belongs to the carbohydrate kinase PfkB family
YPD4_1149	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
YPD4_1149	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD4_1149	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD4_1150	COG3710	Transcriptional regulator
YPD4_1153	COG3121	Chaperone
YPD4_1154	COG3188	usher protein
YPD4_1156	COG2855	membrane
YPD4_1157	COG2855	membrane
YPD4_1158	COG0583	DNA-binding transcription factor activity
YPD4_1159	COG0833	amino acid
YPD4_1161	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD4_1163	COG4771	TonB-dependent receptor
YPD4_1164	COG0625	glutathione transferase activity
YPD4_1169	COG2011	ABC-type metal ion transport system permease component
YPD4_1170	COG1686	Belongs to the peptidase S11 family
YPD4_1171	COG0814	amino acid
YPD4_1172	COG1349	DNA-binding transcription factor activity
YPD4_1173	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YPD4_1174	COG0671	phosphoesterase, PA-phosphatase related
YPD4_1176	COG0569	domain protein
YPD4_1176	COG2985	domain, Protein
YPD4_1178	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
YPD4_1179	COG3842	ATPase activity
YPD4_1180	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPD4_1181	COG1177	transmembrane transport
YPD4_1185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_1188	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD4_1189	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD4_1190	COG1120	ATPase activity
YPD4_1194	COG4160	amino acid transport
YPD4_1195	COG4215	(ABC) transporter
YPD4_1196	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_1197	COG1126	abc transporter atp-binding protein
YPD4_1198	COG1605	Chorismate mutase
YPD4_1200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD4_1201	COG0702	epimerase
YPD4_1202	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
YPD4_1203	COG0028	Belongs to the TPP enzyme family
YPD4_1204	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD4_1206	COG2431	L-lysine efflux transmembrane transporter activity
YPD4_1207	COG3593	DNA synthesis involved in DNA repair
YPD4_1208	COG2990	Protein conserved in bacteria
YPD4_1209	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD4_1212	COG0542	response to heat
YPD4_1215	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
YPD4_1217	COG0492	ferredoxin-NADP+ reductase activity
YPD4_1219	COG1674	ftsk spoiiie
YPD4_1219	COG3107	peptidoglycan biosynthetic process
YPD4_1221	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YPD4_1223	COG2814	Major facilitator Superfamily
YPD4_1224	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
YPD4_1226	COG1882	Formate acetyltransferase
YPD4_1227	COG1882	Formate acetyltransferase
YPD4_1228	COG2116	formate transmembrane transporter activity
YPD4_1229	COG1944	ATP diphosphatase activity
YPD4_1230	COG0252	asparaginase activity
YPD4_1231	COG5295	Hep Hag repeat protein
YPD4_1231	COG5295	Hep Hag repeat protein
YPD4_1236	COG0539	negative regulation of cytoplasmic translation
YPD4_1237	COG0658	competence protein
YPD4_1237	COG2333	competence protein COMEC
YPD4_1240	COG5383	Protein conserved in bacteria
YPD4_1242	COG3173	Aminoglycoside phosphotransferase
YPD4_1243	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YPD4_1244	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
YPD4_1245	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
YPD4_1248	COG2989	Protein conserved in bacteria
YPD4_1249	COG2989	Protein conserved in bacteria
YPD4_1250	COG3108	Peptidase M15
YPD4_1251	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YPD4_1252	COG1448	Aminotransferase
YPD4_1256	COG0308	aminopeptidase N
YPD4_1257	COG0308	aminopeptidase N
YPD4_1260	COG0633	Ferredoxin
YPD4_1260	COG3217	Mosc domain protein beta barrel domain protein
YPD4_1262	COG0488	(ABC) transporter
YPD4_1263	COG2995	paraquat-inducible protein a
YPD4_1264	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YPD4_1264	COG3008	intermembrane lipid transfer
YPD4_1265	COG3009	Protein conserved in bacteria
YPD4_1266	COG1943	Transposase
YPD4_1267	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD4_1270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD4_1272	COG1067	ATP-dependent peptidase activity
YPD4_1274	COG1943	Transposase
YPD4_1275	COG2885	chlorophyll binding
YPD4_1275	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
YPD4_1277	COG3070	regulator of competence-specific genes
YPD4_1278	COG1289	transmembrane transporter activity
YPD4_1279	COG3304	Inner membrane component domain
YPD4_1280	COG0210	DNA helicase
YPD4_1282	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
YPD4_1283	COG1832	CoA-binding protein
YPD4_1286	COG2920	part of a sulfur-relay system
YPD4_1290	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_1291	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YPD4_1292	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD4_1293	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_1294	COG3425	synthase
YPD4_1296	COG1024	Enoyl-CoA hydratase
YPD4_1297	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_1299	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YPD4_1325	COG0488	(ABC) transporter
YPD4_1327	COG3328	transposase activity
YPD4_1329	COG0303	'Molybdopterin
YPD4_1331	COG1136	(ABC) transporter
YPD4_1336	COG0583	DNA-binding transcription factor activity
YPD4_1337	COG0477	Major facilitator Superfamily
YPD4_1339	COG2311	Membrane
YPD4_1342	COG4211	Belongs to the binding-protein-dependent transport system permease family
YPD4_1343	COG2949	membrane
YPD4_1346	COG1346	cytolysis
YPD4_1348	COG2814	Major facilitator Superfamily
YPD4_1352	COG1943	Transposase
YPD4_1354	COG0489	protein tyrosine kinase activity
YPD4_1357	COG2982	Protein involved in outer membrane biogenesis
YPD4_1358	COG1253	flavin adenine dinucleotide binding
YPD4_1359	COG4114	ferric iron reductase
YPD4_1360	COG0076	glutamate decarboxylase activity
YPD4_1361	COG3486	L-lysine 6-monooxygenase (NADPH) activity
YPD4_1364	COG1120	ATPase activity
YPD4_1365	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD4_1366	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD4_1367	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YPD4_1370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YPD4_1371	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YPD4_1373	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YPD4_1373	COG0140	phosphoribosyl-ATP diphosphatase activity
YPD4_1376	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
YPD4_1377	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YPD4_1377	COG0131	Imidazoleglycerol-phosphate dehydratase
YPD4_1379	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
YPD4_1381	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD4_1383	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_1384	COG1129	ABC transporter
YPD4_1385	COG1129	ABC transporter
YPD4_1386	COG0371	Dehydrogenase
YPD4_1387	COG0531	amino acid
YPD4_1388	COG2925	Exonuclease
YPD4_1390	COG3328	transposase activity
YPD4_1391	COG2373	Large extracellular alpha-helical protein
YPD4_1391	COG4932	domain protein
YPD4_1391	COG1388	LysM domain
YPD4_1392	COG2271	Major facilitator Superfamily
YPD4_1393	COG3011	Protein conserved in bacteria
YPD4_1394	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_1396	COG4948	Mandelate Racemase Muconate Lactonizing
YPD4_1399	COG0534	Mate efflux family protein
YPD4_1403	COG3122	Protein conserved in bacteria
YPD4_1407	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YPD4_1410	COG2223	nitrite transmembrane transporter activity
YPD4_1411	COG3328	transposase activity
YPD4_1412	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPD4_1415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPD4_1416	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPD4_1417	COG1121	(ABC) transporter
YPD4_1418	COG0803	Belongs to the bacterial solute-binding protein 9 family
YPD4_1424	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
YPD4_1425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YPD4_1425	COG0072	phenylalanine-tRNA ligase activity
YPD4_1428	COG0386	Belongs to the glutathione peroxidase family
YPD4_1429	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
YPD4_1437	COG0791	NLP P60 protein
YPD4_1443	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YPD4_1443	COG0574	Belongs to the PEP-utilizing enzyme family
YPD4_1444	COG0628	permease
YPD4_1445	COG0247	lactate metabolic process
YPD4_1445	COG0277	FAD linked oxidase domain protein
YPD4_1446	COG2050	protein possibly involved in aromatic compounds catabolism
YPD4_1447	COG0316	Belongs to the HesB IscA family
YPD4_1448	COG0719	Fe-S assembly protein
YPD4_1449	COG0396	ATPase activity
YPD4_1450	COG0719	Fe-S assembly protein
YPD4_1453	COG1376	ErfK ybiS ycfS ynhG family protein
YPD4_1453	COG1388	LysM domain
YPD4_1460	COG0307	riboflavin synthase, alpha
YPD4_1461	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YPD4_1462	COG2814	Major facilitator Superfamily
YPD4_1463	COG0583	DNA-binding transcription factor activity
YPD4_1465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YPD4_1466	COG0791	NLP P60 protein
YPD4_1467	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
YPD4_1468	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YPD4_1469	COG0346	lactoylglutathione lyase activity
YPD4_1471	COG1902	pentaerythritol trinitrate reductase activity
YPD4_1472	COG1309	transcriptional regulator
YPD4_1473	COG2194	sulfuric ester hydrolase activity
YPD4_1474	COG4989	oxidoreductase activity
YPD4_1476	COG3133	Outer membrane lipoprotein
YPD4_1478	COG3895	Periplasmic Protein
YPD4_1482	COG0625	glutathione transferase activity
YPD4_1484	COG3104	oligopeptide transport
YPD4_1485	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPD4_1485	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPD4_1486	COG4172	Belongs to the ABC transporter superfamily
YPD4_1488	COG4171	peptide transport system, permease
YPD4_1489	COG4168	peptide transport system, permease
YPD4_1490	COG4166	transmembrane transport
YPD4_1492	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
YPD4_1493	COG1842	Phage shock protein A
YPD4_1494	COG1983	PspC domain protein
YPD4_1495	COG3106	COG3106 Predicted ATPase
YPD4_1496	COG3106	COG3106 Predicted ATPase
YPD4_1501	COG1943	Transposase
YPD4_1502	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
YPD4_1507	COG3121	Chaperone
YPD4_1510	COG3008	intermembrane lipid transfer
YPD4_1511	COG2995	paraquat-inducible protein a
YPD4_1512	COG1956	GAF domain-containing protein
YPD4_1514	COG0793	Belongs to the peptidase S41A family
YPD4_1516	COG3539	Fimbrial protein
YPD4_1517	COG3121	Chaperone
YPD4_1520	COG3121	Chaperone
YPD4_1521	COG2814	Major facilitator Superfamily
YPD4_1522	COG2814	Major facilitator Superfamily
YPD4_1523	COG0823	Involved in the tonB-independent uptake of proteins
YPD4_1525	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPD4_1527	COG1988	membrane-bound metal-dependent
YPD4_1528	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YPD4_1529	COG1653	transport
YPD4_1530	COG3842	ATPase activity
YPD4_1531	COG0395	ABC-type sugar transport system, permease component
YPD4_1532	COG1175	transmembrane transport
YPD4_1534	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_1536	COG1917	Cupin 2, conserved barrel domain protein
YPD4_1537	COG3328	transposase activity
YPD4_1543	COG1132	(ABC) transporter
YPD4_1544	COG2207	Transcriptional regulator
YPD4_1545	COG1113	amino acid transport
YPD4_1546	COG1113	amino acid transport
YPD4_1549	COG2226	methyltransferase
YPD4_1550	COG5001	Diguanylate cyclase
YPD4_1550	COG3447	MASE1 domain protein
YPD4_1550	COG5002	protein histidine kinase activity
YPD4_1554	COG3716	PTS system mannose fructose sorbose family IID component
YPD4_1555	COG3715	PTS system
YPD4_1556	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD4_1556	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD4_1557	COG1253	flavin adenine dinucleotide binding
YPD4_1558	COG1846	Transcriptional regulator
YPD4_1561	COG1012	belongs to the aldehyde dehydrogenase family
YPD4_1562	COG3384	dioxygenase
YPD4_1564	COG3971	2-oxopent-4-enoate hydratase activity
YPD4_1567	COG2368	4-hydroxyphenylacetate
YPD4_1568	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YPD4_1569	COG1760	l-serine dehydratase
YPD4_1573	COG0513	Belongs to the DEAD box helicase family
YPD4_1574	COG3141	response to X-ray
YPD4_1577	COG1770	oligopeptidase
YPD4_1579	COG1528	Iron-storage protein
YPD4_1580	COG2372	response to copper ion
YPD4_1585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPD4_1586	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPD4_1591	COG3418	PFAM FlgN family protein
YPD4_1592	COG2747	anti-sigma28 factor FlgM
YPD4_1594	COG1815	bacterial-type flagellum-dependent cell motility
YPD4_1595	COG1558	bacterial-type flagellum-dependent cell motility
YPD4_1596	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
YPD4_1597	COG1749	Flagellar hook protein flgE
YPD4_1599	COG4786	Flagellar basal body rod
YPD4_1603	COG1256	bacterial-type flagellum assembly
YPD4_1605	COG2390	Transcriptional regulator
YPD4_1606	COG3347	Dehydrogenase
YPD4_1606	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_1607	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_1609	COG1129	ABC transporter
YPD4_1610	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_1611	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD4_1618	COG1580	Controls the rotational direction of flagella during chemotaxis
YPD4_1620	COG2882	bacterial-type flagellum organization
YPD4_1621	COG1157	protein secretion by the type III secretion system
YPD4_1622	COG1157	protein secretion by the type III secretion system
YPD4_1624	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
YPD4_1626	COG1677	Flagellar hook-basal body complex protein FliE
YPD4_1627	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
YPD4_1628	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
YPD4_1629	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YPD4_1634	COG1191	sigma factor activity
YPD4_1636	COG2515	1-aminocyclopropane-1-carboxylate deaminase
YPD4_1641	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YPD4_1641	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YPD4_1641	COG0506	proline dehydrogenase activity
YPD4_1645	COG2837	iron assimilation
YPD4_1648	COG1113	amino acid transport
YPD4_1650	COG3136	membrane protein required for alginate biosynthesis
YPD4_1651	COG2197	response regulator
YPD4_1659	COG3328	transposase activity
YPD4_1660	COG3328	transposase activity
YPD4_1664	COG0673	inositol 2-dehydrogenase activity
YPD4_1666	COG1175	transmembrane transport
YPD4_1667	COG0395	ABC-type sugar transport system, permease component
YPD4_1673	COG4771	TonB-dependent receptor
YPD4_1674	COG1021	2,3-dihydroxybenzoate-AMP ligase
YPD4_1678	COG2226	methyltransferase
YPD4_1678	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPD4_1678	COG3433	isochorismatase activity
YPD4_1681	COG1132	(ABC) transporter
YPD4_1682	COG2814	Major facilitator Superfamily
YPD4_1683	COG1169	isochorismate synthase
YPD4_1684	COG0582	viral genome integration into host DNA
YPD4_1685	COG3121	Chaperone
YPD4_1688	COG3188	usher protein
YPD4_1691	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_1691	COG2205	protein histidine kinase activity
YPD4_1693	COG0427	acetyl-CoA hydrolase
YPD4_1694	COG2030	dehydratase
YPD4_1702	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YPD4_1703	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YPD4_1705	COG1349	DNA-binding transcription factor activity
YPD4_1706	COG2066	Belongs to the glutaminase family
YPD4_1708	COG0672	)-iron permease
YPD4_1711	COG0577	efflux transmembrane transporter activity
YPD4_1711	COG1136	(ABC) transporter
YPD4_1713	COG0577	efflux transmembrane transporter activity
YPD4_1713	COG1136	(ABC) transporter
YPD4_1717	COG0006	proline dipeptidase activity
YPD4_1718	COG0457	Tetratricopeptide repeat
YPD4_1719	COG1649	PFAM Uncharacterised BCR, COG1649
YPD4_1719	COG0726	polysaccharide deacetylase
YPD4_1720	COG1215	transferase activity, transferring glycosyl groups
YPD4_1721	COG3658	cytochrome
YPD4_1723	COG1702	phosphate starvation-inducible protein PhoH
YPD4_1724	COG0387	Pfam Sodium calcium exchanger
YPD4_1725	COG3850	Histidine kinase
YPD4_1726	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YPD4_1738	COG0402	S-adenosylhomocysteine deaminase activity
YPD4_1741	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YPD4_1742	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YPD4_1743	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD4_1752	COG3328	transposase activity
YPD4_1756	COG0500	methyltransferase
YPD4_1764	COG5002	protein histidine kinase activity
YPD4_1774	COG0012	GTP binding
YPD4_1776	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YPD4_1781	COG2890	protein-(glutamine-N5) methyltransferase activity
YPD4_1782	COG3094	Invasion gene expression up-regulator, SirB
YPD4_1783	COG2912	Transglutaminase-like superfamily
YPD4_1785	COG0659	secondary active sulfate transmembrane transporter activity
YPD4_1786	COG0659	secondary active sulfate transmembrane transporter activity
YPD4_1789	COG3833	ABC-type maltose transport systems, permease component
YPD4_1790	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPD4_1793	COG3842	ATPase activity
YPD4_1794	COG0584	glycerophosphoryl diester phosphodiesterase
YPD4_1795	COG1940	carbohydrate kinase activity
YPD4_1797	COG3381	protein complex oligomerization
YPD4_1800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPD4_1802	COG0728	peptidoglycan biosynthetic process
YPD4_1807	COG3102	Protein conserved in bacteria
YPD4_1811	COG3788	relative of glutathione S-transferase, MAPEG superfamily
YPD4_1812	COG1801	Protein of unknown function DUF72
YPD4_1814	COG0494	nUDIX hydrolase
YPD4_1819	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPD4_1821	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
YPD4_1822	COG0739	heme binding
YPD4_1823	COG1560	Kdo2-lipid A biosynthetic process
YPD4_1824	COG0469	pyruvate kinase activity
YPD4_1825	COG1737	Transcriptional regulator
YPD4_1826	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YPD4_1827	COG0800	Aldolase
YPD4_1830	COG0251	oxidation-reduction process
YPD4_1831	COG1199	ATP-dependent helicase activity
YPD4_1833	COG3065	identical protein binding
YPD4_1834	COG0318	PFAM AMP-dependent synthetase and ligase
YPD4_1835	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
YPD4_1836	COG2894	cell division
YPD4_1838	COG2951	lytic endotransglycosylase activity
YPD4_1839	COG0179	Fumarylacetoacetate (FAA) hydrolase
YPD4_1841	COG0582	viral genome integration into host DNA
YPD4_1854	COG3328	transposase activity
YPD4_1878	COG3328	transposase activity
YPD4_1880	COG1104	cysteine desulfurase activity
YPD4_1886	COG2719	SpoVR family
YPD4_1888	COG2814	Major facilitator Superfamily
YPD4_1890	COG0583	DNA-binding transcription factor activity
YPD4_1893	COG2766	serine protein kinase
YPD4_1894	COG3713	MltA-interacting MipA family protein
YPD4_1899	COG1335	isochorismatase
YPD4_1900	COG0252	asparaginase activity
YPD4_1901	COG0616	signal peptide processing
YPD4_1902	COG0778	Nitroreductase
YPD4_1903	COG0709	Synthesizes selenophosphate from selenide and ATP
YPD4_1904	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YPD4_1905	COG0494	nUDIX hydrolase
YPD4_1906	COG0708	Exodeoxyribonuclease III
YPD4_1907	COG0583	DNA-binding transcription factor activity
YPD4_1908	COG3328	transposase activity
YPD4_1909	COG0788	formyltetrahydrofolate deformylase activity
YPD4_1911	COG0745	RESPONSE REGULATOR receiver
YPD4_1914	COG1435	thymidine kinase activity
YPD4_1917	COG1454	alcohol dehydrogenase
YPD4_1917	COG1012	belongs to the aldehyde dehydrogenase family
YPD4_1918	COG1012	belongs to the aldehyde dehydrogenase family
YPD4_1918	COG1454	alcohol dehydrogenase
YPD4_1919	COG2095	MarC family integral membrane protein
YPD4_1921	COG0601	transmembrane transport
YPD4_1922	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPD4_1923	COG0444	Belongs to the ABC transporter superfamily
YPD4_1924	COG4608	Belongs to the ABC transporter superfamily
YPD4_1928	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
YPD4_1929	COG3328	transposase activity
YPD4_1930	COG1607	acyl-coa hydrolase
YPD4_1935	COG3047	cAMP biosynthetic process
YPD4_1939	COG0135	phosphoribosylanthranilate isomerase activity
YPD4_1939	COG0134	indole-3-glycerol-phosphate synthase activity
YPD4_1941	COG0512	Glutamine amidotransferase of anthranilate synthase
YPD4_1944	COG0009	L-threonylcarbamoyladenylate synthase
YPD4_1945	COG1187	pseudouridine synthase activity
YPD4_1947	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_1948	COG0616	signal peptide processing
YPD4_1949	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YPD4_1950	COG0583	DNA-binding transcription factor activity
YPD4_1952	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
YPD4_1953	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YPD4_1954	COG0671	phosphoesterase, PA-phosphatase related
YPD4_1955	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
YPD4_1956	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
YPD4_1958	COG0023	Translation Initiation Factor
YPD4_1960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YPD4_1961	COG2879	small protein
YPD4_1962	COG1966	Carbon starvation protein
YPD4_1964	COG2271	Major facilitator Superfamily
YPD4_1965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD4_1966	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YPD4_1968	COG4659	FMN binding
YPD4_1969	COG4658	electron transport chain
YPD4_1970	COG2207	Transcriptional regulator
YPD4_1970	COG3708	Transcriptional regulator
YPD4_1977	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD4_1978	COG2274	protein secretion by the type I secretion system
YPD4_1981	COG1879	ABC-type sugar transport system periplasmic component
YPD4_1983	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_1985	COG0673	inositol 2-dehydrogenase activity
YPD4_1986	COG0385	Bile acid
YPD4_1988	COG5339	Protein conserved in bacteria
YPD4_1990	COG0114	fumarate hydratase activity
YPD4_1992	COG2814	Major facilitator Superfamily
YPD4_1993	COG0583	DNA-binding transcription factor activity
YPD4_1994	COG1940	carbohydrate kinase activity
YPD4_1995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YPD4_1996	COG0038	chloride channel
YPD4_1997	COG1609	Transcriptional regulator
YPD4_1999	COG1879	ABC-type sugar transport system periplasmic component
YPD4_2000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YPD4_2001	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPD4_2002	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YPD4_2007	COG0028	Belongs to the TPP enzyme family
YPD4_2008	COG0440	acetolactate synthase activity
YPD4_2009	COG1011	Hydrolase
YPD4_2013	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YPD4_2014	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YPD4_2015	COG0589	response to stress
YPD4_2016	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
YPD4_2017	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
YPD4_2019	COG0531	amino acid
YPD4_2021	COG0745	RESPONSE REGULATOR receiver
YPD4_2022	COG2205	protein histidine kinase activity
YPD4_2023	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
YPD4_2028	COG3038	cytochrome b561
YPD4_2029	COG3591	Belongs to the peptidase S1B family
YPD4_2032	COG1643	Atp-dependent helicase
YPD4_2034	COG2390	Transcriptional regulator
YPD4_2035	COG0246	Mannitol dehydrogenase
YPD4_2036	COG3784	Protein of unknown function (DUF1318)
YPD4_2037	COG2911	Protein conserved in bacteria
YPD4_2038	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YPD4_2039	COG3187	Heat shock protein
YPD4_2040	COG3042	response to heat
YPD4_2041	COG1285	pathogenesis
YPD4_2043	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPD4_2043	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YPD4_2043	COG1013	pyruvate-flavodoxin oxidoreductase activity
YPD4_2043	COG0674	pyruvate-flavodoxin oxidoreductase activity
YPD4_2045	COG2755	lipolytic protein G-D-S-L family
YPD4_2045	COG0657	acetylesterase activity
YPD4_2048	COG4166	transmembrane transport
YPD4_2049	COG2866	Carboxypeptidase
YPD4_2050	COG4948	Mandelate Racemase Muconate Lactonizing
YPD4_2054	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YPD4_2056	COG5295	Hep Hag repeat protein
YPD4_2058	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPD4_2059	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
YPD4_2060	COG0745	RESPONSE REGULATOR receiver
YPD4_2062	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YPD4_2063	COG0840	transmembrane signaling receptor activity
YPD4_2064	COG0840	transmembrane signaling receptor activity
YPD4_2068	COG2964	Protein conserved in bacteria
YPD4_2070	COG0251	oxidation-reduction process
YPD4_2071	COG2271	Major facilitator Superfamily
YPD4_2072	COG0835	chemotaxis
YPD4_2073	COG0643	Histidine kinase
YPD4_2073	COG2198	Histidine kinase
YPD4_2075	COG1360	Flagellar Motor Protein
YPD4_2079	COG1285	pathogenesis
YPD4_2080	COG0840	transmembrane signaling receptor activity
YPD4_2081	COG0840	transmembrane signaling receptor activity
YPD4_2083	COG3321	synthase
YPD4_2083	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_2083	COG0604	alcohol dehydrogenase
YPD4_2085	COG1522	sequence-specific DNA binding
YPD4_2088	COG1733	regulation of RNA biosynthetic process
YPD4_2089	COG0702	epimerase
YPD4_2090	COG0840	transmembrane signaling receptor activity
YPD4_2092	COG0538	isocitrate dehydrogenase activity
YPD4_2093	COG1187	pseudouridine synthase activity
YPD4_2097	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YPD4_2099	COG0745	RESPONSE REGULATOR receiver
YPD4_2101	COG2850	peptidyl-arginine hydroxylation
YPD4_2103	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
YPD4_2105	COG4591	ABC-type transport system involved in lipoprotein release permease component
YPD4_2107	COG4591	ABC-type transport system involved in lipoprotein release permease component
YPD4_2108	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
YPD4_2109	COG3134	Outer membrane lipoprotein
YPD4_2110	COG3328	transposase activity
YPD4_2113	COG1252	NADH dehydrogenase
YPD4_2115	COG1472	Belongs to the glycosyl hydrolase 3 family
YPD4_2118	COG5633	Lipoprotein
YPD4_2119	COG0537	adenosine 5'-monophosphoramidase activity
YPD4_2120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YPD4_2122	COG1263	PTS System
YPD4_2122	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD4_2123	COG0084	hydrolase, TatD family'
YPD4_2124	COG0470	DNA polymerase III
YPD4_2126	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YPD4_2127	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YPD4_2128	COG1943	Transposase
YPD4_2129	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD4_2130	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_2134	COG1399	metal-binding, possibly nucleic acid-binding protein
YPD4_2137	COG0564	pseudouridine synthase activity
YPD4_2138	COG1530	ribonuclease E activity
YPD4_2139	COG3328	transposase activity
YPD4_2141	COG3328	transposase activity
YPD4_2144	COG0628	permease
YPD4_2147	COG3916	Acyl-homoserine-lactone synthase
YPD4_2148	COG2771	luxR family
YPD4_2149	COG0583	DNA-binding transcription factor activity
YPD4_2150	COG0477	Major facilitator Superfamily
YPD4_2152	COG0667	Aldo Keto reductase
YPD4_2157	COG1203	CRISPR-associated helicase, Cas3
YPD4_2158	COG1518	maintenance of DNA repeat elements
YPD4_2159	COG0668	transmembrane transport
YPD4_2163	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
YPD4_2164	COG0395	ABC-type sugar transport system, permease component
YPD4_2167	COG1609	Transcriptional regulator
YPD4_2169	COG3842	ATPase activity
YPD4_2171	COG3210	domain, Protein
YPD4_2173	COG3210	domain, Protein
YPD4_2174	COG3210	domain, Protein
YPD4_2176	COG3210	domain, Protein
YPD4_2177	COG2831	hemolysin activation secretion protein
YPD4_2178	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD4_2179	COG4638	Rieske (2fe-2S)
YPD4_2180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YPD4_2181	COG0473	3-isopropylmalate dehydrogenase activity
YPD4_2182	COG0583	DNA-binding transcription factor activity
YPD4_2183	COG1609	Transcriptional regulator
YPD4_2184	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_2185	COG1129	ABC transporter
YPD4_2186	COG1879	ABC-type sugar transport system periplasmic component
YPD4_2187	COG1063	alcohol dehydrogenase
YPD4_2191	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
YPD4_2197	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_2198	COG0765	amino acid transport
YPD4_2199	COG1126	abc transporter atp-binding protein
YPD4_2205	COG2453	phosphatase
YPD4_2205	COG0671	phosphoesterase, PA-phosphatase related
YPD4_2206	COG2267	carboxylic ester hydrolase activity
YPD4_2208	COG4589	Belongs to the CDS family
YPD4_2209	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
YPD4_2212	COG1943	Transposase
YPD4_2215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
YPD4_2216	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPD4_2220	COG0581	inorganic phosphate transmembrane transporter activity
YPD4_2222	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
YPD4_2223	COG0248	Ppx GppA phosphatase
YPD4_2224	COG2239	Acts as a magnesium transporter
YPD4_2225	COG0443	Heat shock 70 kDa protein
YPD4_2226	COG1177	transmembrane transport
YPD4_2228	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPD4_2230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YPD4_2232	COG3842	ATPase activity
YPD4_2237	COG2205	protein histidine kinase activity
YPD4_2238	COG0745	RESPONSE REGULATOR receiver
YPD4_2239	COG3422	double-strand break repair
YPD4_2244	COG0351	phosphomethylpyrimidine kinase
YPD4_2246	COG3328	transposase activity
YPD4_2251	COG1943	Transposase
YPD4_2253	COG0516	GMP reductase activity
YPD4_2253	COG0517	IMP dehydrogenase activity
YPD4_2257	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPD4_2258	COG2976	Protein conserved in bacteria
YPD4_2266	COG3468	outer membrane autotransporter barrel domain protein
YPD4_2267	COG3468	outer membrane autotransporter barrel domain protein
YPD4_2271	COG0633	Ferredoxin
YPD4_2272	COG0443	Heat shock 70 kDa protein
YPD4_2275	COG0822	iron-sulfur transferase activity
YPD4_2277	COG1104	cysteine desulfurase activity
YPD4_2280	COG0483	inositol monophosphate 1-phosphatase activity
YPD4_2281	COG1943	Transposase
YPD4_2282	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
YPD4_2283	COG3683	transport system, periplasmic component
YPD4_2284	COG3711	transcriptional antiterminator
YPD4_2285	COG2814	Major facilitator Superfamily
YPD4_2286	COG2814	Major facilitator Superfamily
YPD4_2289	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD4_2289	COG1017	nitric oxide dioxygenase activity
YPD4_2290	COG2188	Transcriptional regulator
YPD4_2291	COG2188	Transcriptional regulator
YPD4_2292	COG0347	Belongs to the P(II) protein family
YPD4_2293	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YPD4_2293	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPD4_2294	COG2204	response regulator
YPD4_2295	COG3170	Tfp pilus assembly protein FimV
YPD4_2296	COG2205	protein histidine kinase activity
YPD4_2302	COG0590	tRNA wobble adenosine to inosine editing
YPD4_2303	COG0560	Phosphoserine phosphatase
YPD4_2305	COG1737	Transcriptional regulator
YPD4_2306	COG1943	Transposase
YPD4_2308	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
YPD4_2314	COG0681	Belongs to the peptidase S26 family
YPD4_2317	COG3086	response to oxidative stress
YPD4_2318	COG3026	antisigma factor binding
YPD4_2319	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
YPD4_2321	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
YPD4_2323	COG0513	Belongs to the DEAD box helicase family
YPD4_2332	COG1984	allophanate hydrolase subunit 2
YPD4_2333	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
YPD4_2334	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
YPD4_2335	COG5212	phosphodiesterase
YPD4_2337	COG3272	Protein of unknown function (DUF1722)
YPD4_2341	COG2205	protein histidine kinase activity
YPD4_2342	COG0745	RESPONSE REGULATOR receiver
YPD4_2344	COG0033	Phosphoglucomutase
YPD4_2345	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
YPD4_2347	COG1917	Cupin 2, conserved barrel domain protein
YPD4_2347	COG2169	Transcriptional regulator
YPD4_2348	COG1447	Phosphotransferase system cellobiose-specific component IIA
YPD4_2349	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YPD4_2350	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YPD4_2351	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPD4_2352	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPD4_2353	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YPD4_2355	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
YPD4_2356	COG4413	Urea transporter
YPD4_2358	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
YPD4_2364	COG1124	(ABC) transporter
YPD4_2365	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YPD4_2366	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPD4_2368	COG0747	negative chemotaxis
YPD4_2376	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YPD4_2377	COG4175	Glycine betaine
YPD4_2378	COG4176	ABC-type proline glycine betaine transport system permease component
YPD4_2379	COG2113	Glycine betaine
YPD4_2383	COG0582	viral genome integration into host DNA
YPD4_2384	COG0596	Alpha beta hydrolase
YPD4_2386	COG0735	belongs to the Fur family
YPD4_2391	COG1943	Transposase
YPD4_2393	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD4_2393	COG1263	PTS System
YPD4_2393	COG2190	(PTS) system
YPD4_2395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
YPD4_2396	COG1940	carbohydrate kinase activity
YPD4_2396	COG1846	Transcriptional regulator
YPD4_2397	COG0647	UMP catabolic process
YPD4_2398	COG0367	asparagine synthase
YPD4_2399	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPD4_2401	COG1702	phosphate starvation-inducible protein PhoH
YPD4_2403	COG4535	Mg2 and Co2 transporter CorC
YPD4_2404	COG0815	Transfers the fatty acyl group on membrane lipoproteins
YPD4_2406	COG0765	amino acid transport
YPD4_2407	COG0765	amino acid transport
YPD4_2408	COG1126	abc transporter atp-binding protein
YPD4_2409	COG2888	peptidyl-tyrosine sulfation
YPD4_2412	COG1466	dna polymerase III delta subunit
YPD4_2414	COG0799	negative regulation of ribosome biogenesis
YPD4_2416	COG0768	penicillin binding
YPD4_2417	COG0772	Belongs to the SEDS family
YPD4_2418	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YPD4_2419	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YPD4_2420	COG1686	Belongs to the peptidase S11 family
YPD4_2423	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPD4_2424	COG1278	Cold shock
YPD4_2425	COG2197	response regulator
YPD4_2427	COG5265	(ABC) transporter
YPD4_2429	COG3718	enzyme involved in inositol metabolism
YPD4_2431	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD4_2432	COG0673	inositol 2-dehydrogenase activity
YPD4_2433	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_2434	COG1129	ABC transporter
YPD4_2435	COG1879	ABC-type sugar transport system periplasmic component
YPD4_2436	COG0673	inositol 2-dehydrogenase activity
YPD4_2437	COG0673	inositol 2-dehydrogenase activity
YPD4_2438	COG3962	Belongs to the TPP enzyme family
YPD4_2442	COG2373	Large extracellular alpha-helical protein
YPD4_2443	COG4953	penicillin-binding protein 1C
YPD4_2444	COG3328	transposase activity
YPD4_2446	COG1609	Transcriptional regulator
YPD4_2447	COG0857	belongs to the CobB CobQ family
YPD4_2447	COG0280	phosphate acetyltransferase
YPD4_2451	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPD4_2452	COG0471	metal ion transport
YPD4_2452	COG0490	domain, Protein
YPD4_2454	COG0436	Aminotransferase
YPD4_2455	COG0583	DNA-binding transcription factor activity
YPD4_2457	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPD4_2459	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
YPD4_2461	COG1034	ATP synthesis coupled electron transport
YPD4_2464	COG0839	Belongs to the complex I subunit 6 family
YPD4_2466	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
YPD4_2467	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPD4_2470	COG2731	YhcH YjgK YiaL family protein
YPD4_2471	COG3265	gluconokinase activity
YPD4_2472	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_2474	COG1609	Transcriptional regulator
YPD4_2475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YPD4_2478	COG0129	dihydroxy-acid dehydratase activity
YPD4_2479	COG4575	ribosome binding
YPD4_2481	COG1169	isochorismate synthase
YPD4_2484	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
YPD4_2487	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YPD4_2492	COG0667	Aldo Keto reductase
YPD4_2493	COG0656	L-ascorbic acid biosynthetic process
YPD4_2498	COG3328	transposase activity
YPD4_2499	COG2850	peptidyl-arginine hydroxylation
YPD4_2506	COG4953	penicillin-binding protein 1C
YPD4_2507	COG3328	transposase activity
YPD4_2508	COG3037	sugar-specific permease SgaT UlaA
YPD4_2509	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
YPD4_2510	COG0622	Phosphoesterase
YPD4_2512	COG1090	epimerase
YPD4_2513	COG4598	ABC transporter
YPD4_2514	COG4160	amino acid transport
YPD4_2515	COG4215	(ABC) transporter
YPD4_2516	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_2517	COG0163	prenyltransferase activity
YPD4_2518	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
YPD4_2519	COG1286	toxin biosynthetic process
YPD4_2520	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
YPD4_2521	COG0285	dihydrofolate synthase activity
YPD4_2523	COG0586	Pfam SNARE associated Golgi protein
YPD4_2525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YPD4_2528	COG0697	spore germination
YPD4_2531	COG1794	racemase activity, acting on amino acids and derivatives
YPD4_2532	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD4_2533	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD4_2535	COG3101	peptidyl-lysine hydroxylation
YPD4_2536	COG0730	response to heat
YPD4_2539	COG2890	protein-(glutamine-N5) methyltransferase activity
YPD4_2541	COG2062	phosphohistidine phosphatase, SixA
YPD4_2546	COG3088	subunit of a heme lyase
YPD4_2546	COG4235	cytochrome complex assembly
YPD4_2547	COG4235	cytochrome complex assembly
YPD4_2547	COG3088	subunit of a heme lyase
YPD4_2548	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YPD4_2549	COG1138	Cytochrome C-type biogenesis protein
YPD4_2551	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPD4_2552	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPD4_2553	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPD4_2556	COG1704	LemA family
YPD4_2558	COG2824	Alkylphosphonate utilization operon protein PhnA
YPD4_2563	COG3501	Rhs element vgr protein
YPD4_2575	COG3188	usher protein
YPD4_2576	COG3328	transposase activity
YPD4_2577	COG3188	usher protein
YPD4_2578	COG3121	Chaperone
YPD4_2590	COG2951	lytic endotransglycosylase activity
YPD4_2596	COG0243	molybdopterin cofactor binding
YPD4_2597	COG0437	4 iron, 4 sulfur cluster binding
YPD4_2598	COG3302	dmso reductase anchor subunit
YPD4_2599	COG3381	protein complex oligomerization
YPD4_2605	COG3038	cytochrome b561
YPD4_2606	COG0436	Aminotransferase
YPD4_2611	COG0667	Aldo Keto reductase
YPD4_2614	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YPD4_2616	COG1943	Transposase
YPD4_2622	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YPD4_2624	COG2190	(PTS) system
YPD4_2626	COG2205	protein histidine kinase activity
YPD4_2627	COG0745	RESPONSE REGULATOR receiver
YPD4_2628	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD4_2631	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YPD4_2632	COG0006	proline dipeptidase activity
YPD4_2633	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
YPD4_2635	COG3850	Histidine kinase
YPD4_2635	COG5002	protein histidine kinase activity
YPD4_2636	COG0745	RESPONSE REGULATOR receiver
YPD4_2639	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
YPD4_2640	COG4208	sulfate ABC transporter
YPD4_2641	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
YPD4_2642	COG4150	thiosulfate binding
YPD4_2644	COG1737	Transcriptional regulator
YPD4_2645	COG2731	YhcH YjgK YiaL family protein
YPD4_2647	COG4886	Leucine-rich repeat (LRR) protein
YPD4_2650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YPD4_2651	COG2837	iron assimilation
YPD4_2653	COG3111	PFAM Bacterial OB fold (BOF) protein
YPD4_2661	COG3005	denitrification pathway
YPD4_2662	COG3043	anaerobic respiration
YPD4_2664	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPD4_2664	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPD4_2665	COG2197	response regulator
YPD4_2666	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPD4_2668	COG1988	membrane-bound metal-dependent
YPD4_2669	COG0641	radical SAM
YPD4_2670	COG3119	arylsulfatase activity
YPD4_2671	COG3842	ATPase activity
YPD4_2672	COG1175	transmembrane transport
YPD4_2673	COG1840	ABC-type Fe3 transport system, periplasmic component
YPD4_2675	COG1393	Belongs to the ArsC family
YPD4_2677	COG1876	peptidase activity
YPD4_2681	COG2321	neutral zinc metallopeptidase
YPD4_2683	COG1943	Transposase
YPD4_2684	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
YPD4_2686	COG2716	regulation of RNA biosynthetic process
YPD4_2687	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YPD4_2689	COG0628	permease
YPD4_2690	COG4783	chaperone-mediated protein folding
YPD4_2691	COG1393	Belongs to the ArsC family
YPD4_2693	COG1943	Transposase
YPD4_2695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YPD4_2697	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
YPD4_2698	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
YPD4_2699	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
YPD4_2700	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
YPD4_2701	COG4181	ATPase activity
YPD4_2702	COG2755	lipolytic protein G-D-S-L family
YPD4_2703	COG0300	oxidoreductase activity
YPD4_2704	COG3118	belongs to the thioredoxin family
YPD4_2705	COG0330	HflC and HflK could
YPD4_2706	COG1585	Membrane protein implicated in regulation of membrane protease activity
YPD4_2707	COG0789	Transcriptional regulator
YPD4_2708	COG2217	Heavy metal translocating P-type atpase
YPD4_2709	COG3735	TraB family
YPD4_2710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YPD4_2711	COG0737	Belongs to the 5'-nucleotidase family
YPD4_2712	COG0737	Belongs to the 5'-nucleotidase family
YPD4_2713	COG2223	nitrite transmembrane transporter activity
YPD4_2714	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YPD4_2714	COG4651	solute:proton antiporter activity
YPD4_2715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD4_2716	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YPD4_2720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD4_2721	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
YPD4_2722	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
YPD4_2729	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD4_2733	COG0543	2 iron, 2 sulfur cluster binding
YPD4_2733	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD4_2739	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
YPD4_2742	COG3264	Mechanosensitive ion channel
YPD4_2742	COG1196	nuclear chromosome segregation
YPD4_2743	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
YPD4_2744	COG1309	transcriptional regulator
YPD4_2745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD4_2746	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPD4_2747	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPD4_2750	COG3695	enzyme binding
YPD4_2751	COG3126	Type III secretion system lipoprotein chaperone (YscW)
YPD4_2752	COG1946	Acyl-CoA thioesterase
YPD4_2753	COG0004	ammonium transporteR
YPD4_2754	COG0347	Belongs to the P(II) protein family
YPD4_2755	COG1132	(ABC) transporter
YPD4_2756	COG1132	(ABC) transporter
YPD4_2757	COG1522	sequence-specific DNA binding
YPD4_2760	COG4533	DNA binding
YPD4_2762	COG0824	Thioesterase
YPD4_2763	COG1555	photosystem II stabilization
YPD4_2764	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YPD4_2766	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YPD4_2770	COG0271	Belongs to the BolA IbaG family
YPD4_2771	COG3056	Lipoprotein
YPD4_2772	COG2223	nitrite transmembrane transporter activity
YPD4_2774	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YPD4_2775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YPD4_2776	COG1845	cytochrome c oxidase, subunit III
YPD4_2777	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
YPD4_2779	COG2814	Major facilitator Superfamily
YPD4_2781	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
YPD4_2782	COG0693	protein deglycase activity
YPD4_2784	COG0142	geranyltranstransferase activity
YPD4_2787	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
YPD4_2788	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
YPD4_2791	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YPD4_2791	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YPD4_2795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YPD4_2796	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YPD4_2797	COG1862	Preprotein translocase
YPD4_2799	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
YPD4_2800	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
YPD4_2801	COG0450	alkyl hydroperoxide reductase
YPD4_2804	COG0366	Alpha amylase catalytic
YPD4_2806	COG1114	Component of the transport system for branched-chain amino acids
YPD4_2808	COG5002	protein histidine kinase activity
YPD4_2809	COG0745	RESPONSE REGULATOR receiver
YPD4_2810	COG0420	3'-5' exonuclease activity
YPD4_2811	COG0419	ATPase involved in DNA repair
YPD4_2812	COG1940	carbohydrate kinase activity
YPD4_2816	COG2226	methyltransferase
YPD4_2825	COG2195	Cleaves the N-terminal amino acid of tripeptides
YPD4_2828	COG1477	protein flavinylation
YPD4_2832	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YPD4_2833	COG1805	sodium ion transport
YPD4_2834	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YPD4_2835	COG3034	peptidoglycan biosynthetic process
YPD4_2836	COG0121	glutamine amidotransferase
YPD4_2838	COG1960	acyl-CoA dehydrogenase activity
YPD4_2840	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
YPD4_2844	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YPD4_2847	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YPD4_2855	COG2814	Major facilitator Superfamily
YPD4_2856	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
YPD4_2858	COG1846	Transcriptional regulator
YPD4_2859	COG1566	PFAM secretion protein HlyD family protein
YPD4_2860	COG2814	Major facilitator Superfamily
YPD4_2861	COG2814	Major facilitator Superfamily
YPD4_2862	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPD4_2864	COG0045	succinate-CoA ligase (ADP-forming) activity
YPD4_2864	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPD4_2864	COG1042	CoA-binding domain protein
YPD4_2865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YPD4_2866	COG5544	Lipoprotein
YPD4_2868	COG0542	response to heat
YPD4_2869	COG0542	response to heat
YPD4_2871	COG0564	pseudouridine synthase activity
YPD4_2872	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPD4_2873	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
YPD4_2874	COG1943	Transposase
YPD4_2875	COG0077	Prephenate dehydratase
YPD4_2875	COG1605	Chorismate mutase
YPD4_2876	COG1605	Chorismate mutase
YPD4_2876	COG0287	Prephenate dehydrogenase
YPD4_2877	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YPD4_2878	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YPD4_2879	COG3279	Response regulator of the LytR AlgR family
YPD4_2880	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPD4_2881	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPD4_2882	COG3137	Salt-induced outer membrane protein
YPD4_2887	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YPD4_2888	COG4137	Cytochrome C assembly protein
YPD4_2889	COG4536	flavin adenine dinucleotide binding
YPD4_2892	COG2918	glutathione biosynthetic process
YPD4_2893	COG1238	metal cluster binding
YPD4_2894	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPD4_2902	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YPD4_2903	COG3958	Transketolase
YPD4_2904	COG3959	Transketolase, thiamine diphosphate binding domain
YPD4_2905	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_2906	COG1129	ABC transporter
YPD4_2910	COG3783	Cytochrome b(562)
YPD4_2911	COG3381	protein complex oligomerization
YPD4_2912	COG3302	dmso reductase anchor subunit
YPD4_2913	COG0437	4 iron, 4 sulfur cluster binding
YPD4_2914	COG0243	molybdopterin cofactor binding
YPD4_2915	COG0235	Class ii aldolase
YPD4_2916	COG1349	DNA-binding transcription factor activity
YPD4_2918	COG1129	ABC transporter
YPD4_2919	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_2920	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_2921	COG3623	hexulose-6-phosphate isomerase
YPD4_2922	COG1070	Carbohydrate kinase
YPD4_2923	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
YPD4_2923	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
YPD4_2924	COG0024	Methionine aminopeptidase
YPD4_2927	COG4771	TonB-dependent receptor
YPD4_2930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_2932	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YPD4_2935	COG2376	Dihydroxyacetone kinase
YPD4_2936	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_2937	COG1063	alcohol dehydrogenase
YPD4_2938	COG0698	ribose 5-phosphate isomerase
YPD4_2939	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
YPD4_2940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YPD4_2941	COG1388	LysM domain
YPD4_2941	COG4942	peptidase
YPD4_2946	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
YPD4_2949	COG0529	Catalyzes the synthesis of activated sulfate
YPD4_2957	COG0720	synthase
YPD4_2958	COG0602	queuosine metabolic process
YPD4_2962	COG3956	TIGRFAM MazG family protein
YPD4_2963	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YPD4_2964	COG3850	Histidine kinase
YPD4_2964	COG4999	Histidine kinase
YPD4_2964	COG3437	response regulator, receiver
YPD4_2964	COG2205	protein histidine kinase activity
YPD4_2966	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPD4_2968	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YPD4_2970	COG2860	membrane
YPD4_2974	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD4_2975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YPD4_2976	COG1120	ATPase activity
YPD4_2977	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YPD4_2978	COG1643	Atp-dependent helicase
YPD4_2979	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
YPD4_2981	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
YPD4_2982	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YPD4_2983	COG0617	tRNA 3'-terminal CCA addition
YPD4_2984	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YPD4_2988	COG0726	polysaccharide deacetylase
YPD4_2989	COG0842	Transport permease protein
YPD4_2990	COG1131	(ABC) transporter
YPD4_2991	COG0288	reversible hydration of carbon dioxide
YPD4_2992	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
YPD4_2993	COG2132	Multicopper oxidase
YPD4_2997	COG0697	spore germination
YPD4_2999	COG1049	propionate catabolic process, 2-methylcitrate cycle
YPD4_3001	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPD4_3002	COG0508	dehydrogenase complex catalyzes the overall conversion of
YPD4_3003	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
YPD4_3004	COG2186	Transcriptional regulator
YPD4_3005	COG1113	amino acid transport
YPD4_3006	COG3725	Membrane protein required for beta-lactamase induction
YPD4_3007	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPD4_3009	COG4969	Belongs to the N-Me-Phe pilin family
YPD4_3010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YPD4_3011	COG1459	type II secretion system
YPD4_3013	COG0237	dephospho-CoA kinase activity
YPD4_3020	COG0582	viral genome integration into host DNA
YPD4_3021	COG0795	lipopolysaccharide-transporting ATPase activity
YPD4_3022	COG0795	lipopolysaccharide-transporting ATPase activity
YPD4_3023	COG0795	lipopolysaccharide-transporting ATPase activity
YPD4_3025	COG2927	DNA polymerase III (CHI subunit)
YPD4_3026	COG0525	valine-tRNA ligase activity
YPD4_3028	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
YPD4_3029	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YPD4_3030	COG2731	YhcH YjgK YiaL family protein
YPD4_3033	COG0601	transmembrane transport
YPD4_3034	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPD4_3035	COG0444	Belongs to the ABC transporter superfamily
YPD4_3036	COG4608	Belongs to the ABC transporter superfamily
YPD4_3039	COG2188	Transcriptional regulator
YPD4_3040	COG3624	Phosphonate C-P lyase system protein PhnG
YPD4_3041	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
YPD4_3042	COG3626	phosphonate metabolism
YPD4_3043	COG3627	carbon phosphorus lyase activity
YPD4_3044	COG4107	phosphonate C-P lyase system protein PhnK
YPD4_3045	COG4778	phosphonate C-P lyase system protein PhnL
YPD4_3046	COG3454	Phosphonate metabolism
YPD4_3047	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
YPD4_3048	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YPD4_3049	COG0702	epimerase
YPD4_3052	COG3842	ATPase activity
YPD4_3053	COG0395	ABC-type sugar transport system, permease component
YPD4_3055	COG1653	transport
YPD4_3058	COG3153	acetyltransferase
YPD4_3063	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPD4_3065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YPD4_3067	COG0513	Belongs to the DEAD box helicase family
YPD4_3070	COG2801	Transposase and inactivated derivatives
YPD4_3085	COG3501	Rhs element vgr protein
YPD4_3088	COG3209	COG3209 Rhs family protein
YPD4_3091	COG3501	Rhs element vgr protein
YPD4_3093	COG3209	COG3209 Rhs family protein
YPD4_3096	COG0673	inositol 2-dehydrogenase activity
YPD4_3097	COG2207	Transcriptional regulator
YPD4_3097	COG1917	Cupin 2, conserved barrel domain protein
YPD4_3098	COG1869	D-ribose catabolic process
YPD4_3099	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD4_3101	COG0431	NADPH-dependent FMN reductase
YPD4_3102	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YPD4_3104	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPD4_3106	COG2252	PERMEase
YPD4_3107	COG0025	NhaP-type Na H and K H
YPD4_3109	COG1560	Kdo2-lipid A biosynthetic process
YPD4_3111	COG1129	ABC transporter
YPD4_3112	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_3114	COG1069	ribulokinase activity
YPD4_3116	COG0625	glutathione transferase activity
YPD4_3120	COG3133	Outer membrane lipoprotein
YPD4_3121	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YPD4_3123	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPD4_3124	COG0477	Major facilitator Superfamily
YPD4_3125	COG0477	Major facilitator Superfamily
YPD4_3128	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPD4_3130	COG4145	pantothenate transmembrane transporter activity
YPD4_3131	COG0439	Biotin carboxylase
YPD4_3132	COG0511	ligase activity, forming carbon-carbon bonds
YPD4_3135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
YPD4_3136	COG0604	alcohol dehydrogenase
YPD4_3137	COG2200	EAL domain
YPD4_3137	COG2199	diguanylate cyclase activity
YPD4_3138	COG1077	Cell shape determining protein MreB Mrl
YPD4_3139	COG1792	Involved in formation and maintenance of cell shape
YPD4_3140	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
YPD4_3142	COG1530	ribonuclease E activity
YPD4_3143	COG3164	Protein of unknown function
YPD4_3144	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPD4_3145	COG0312	modulator of DNA gyrase
YPD4_3156	COG0583	DNA-binding transcription factor activity
YPD4_3159	COG1012	belongs to the aldehyde dehydrogenase family
YPD4_3163	COG0312	modulator of DNA gyrase
YPD4_3165	COG3783	Cytochrome b(562)
YPD4_3166	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPD4_3167	COG0366	Alpha amylase catalytic
YPD4_3168	COG1263	PTS System
YPD4_3168	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD4_3169	COG1609	Transcriptional regulator
YPD4_3175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD4_3176	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
YPD4_3177	COG1137	ATPase activity
YPD4_3178	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
YPD4_3179	COG3117	lipopolysaccharide transmembrane transporter activity
YPD4_3180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
YPD4_3181	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
YPD4_3181	COG0517	IMP dehydrogenase activity
YPD4_3182	COG0530	calcium, potassium:sodium antiporter activity
YPD4_3183	COG1127	ABC transporter
YPD4_3184	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YPD4_3185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YPD4_3186	COG2854	intermembrane phospholipid transfer
YPD4_3187	COG3113	response to antibiotic
YPD4_3189	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPD4_3190	COG1943	Transposase
YPD4_3191	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPD4_3192	COG3105	Protein conserved in bacteria
YPD4_3193	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YPD4_3196	COG0625	glutathione transferase activity
YPD4_3197	COG2969	positive regulation of protein catabolic process
YPD4_3199	COG0493	'glutamate synthase
YPD4_3200	COG0069	glutamate synthase activity
YPD4_3200	COG0070	glutamate synthase
YPD4_3200	COG0067	glutamate synthase
YPD4_3201	COG1242	4 iron, 4 sulfur cluster binding
YPD4_3202	COG5002	protein histidine kinase activity
YPD4_3202	COG0784	Response regulator, receiver
YPD4_3202	COG2198	Histidine kinase
YPD4_3203	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
YPD4_3205	COG2823	Periplasmic or secreted lipoprotein
YPD4_3209	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
YPD4_3210	COG1741	Belongs to the pirin family
YPD4_3211	COG0583	DNA-binding transcription factor activity
YPD4_3212	COG0435	Glutathione S-transferase
YPD4_3216	COG1073	alpha beta
YPD4_3217	COG0360	Binds together with S18 to 16S ribosomal RNA
YPD4_3219	COG1943	Transposase
YPD4_3221	COG3061	Opacity-associated protein A
YPD4_3222	COG0545	Peptidyl-prolyl cis-trans isomerase
YPD4_3224	COG0737	Belongs to the 5'-nucleotidase family
YPD4_3225	COG0737	Belongs to the 5'-nucleotidase family
YPD4_3227	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
YPD4_3228	COG1253	flavin adenine dinucleotide binding
YPD4_3230	COG0729	surface antigen
YPD4_3231	COG2911	Protein conserved in bacteria
YPD4_3232	COG2105	PFAM AIG2 family protein
YPD4_3233	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YPD4_3235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YPD4_3239	COG0142	geranyltranstransferase activity
YPD4_3241	COG0697	spore germination
YPD4_3243	COG0642	Histidine kinase
YPD4_3244	COG0745	RESPONSE REGULATOR receiver
YPD4_3245	COG2027	D-alanyl-D-alanine carboxypeptidase
YPD4_3246	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPD4_3247	COG1534	Rna-binding protein
YPD4_3249	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YPD4_3250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YPD4_3253	COG0195	Participates in both transcription termination and antitermination
YPD4_3258	COG2801	Transposase and inactivated derivatives
YPD4_3267	COG1175	transmembrane transport
YPD4_3268	COG3833	ABC-type maltose transport systems, permease component
YPD4_3271	COG0527	aspartate kinase activity
YPD4_3276	COG1414	Transcriptional regulator
YPD4_3277	COG1414	Transcriptional regulator
YPD4_3279	COG2224	Isocitrate lyase
YPD4_3280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
YPD4_3283	COG0151	Belongs to the GarS family
YPD4_3285	COG3068	Protein conserved in bacteria
YPD4_3286	COG1515	deoxyribonuclease V activity
YPD4_3291	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
YPD4_3293	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YPD4_3296	COG1943	Transposase
YPD4_3303	COG0250	Participates in transcription elongation, termination and antitermination
YPD4_3310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
YPD4_3311	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YPD4_3312	COG1739	Uncharacterized protein family UPF0029
YPD4_3325	COG0805	protein transport
YPD4_3330	COG1322	Protein conserved in bacteria
YPD4_3331	COG0586	Pfam SNARE associated Golgi protein
YPD4_3332	COG1966	Carbon starvation protein
YPD4_3334	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
YPD4_3335	COG0412	Dienelactone hydrolase
YPD4_3337	COG0583	DNA-binding transcription factor activity
YPD4_3338	COG0679	Auxin Efflux Carrier
YPD4_3339	COG0584	glycerophosphoryl diester phosphodiesterase
YPD4_3351	COG0410	ABC transporter
YPD4_3352	COG0411	ABC transporter
YPD4_3353	COG4177	L-phenylalanine transmembrane transporter activity
YPD4_3354	COG0559	Belongs to the binding-protein-dependent transport system permease family
YPD4_3355	COG0683	leucine binding
YPD4_3357	COG1943	Transposase
YPD4_3359	COG2177	Part of the ABC transporter FtsEX involved in
YPD4_3360	COG2884	Cell division ATP-binding protein ftsE
YPD4_3361	COG0552	protein localization to endoplasmic reticulum
YPD4_3361	COG0552	protein localization to endoplasmic reticulum
YPD4_3362	COG0742	ribosomal rna small subunit methyltransferase
YPD4_3365	COG3714	YhhN family
YPD4_3368	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
YPD4_3370	COG0247	lactate metabolic process
YPD4_3372	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YPD4_3373	COG0584	glycerophosphoryl diester phosphodiesterase
YPD4_3375	COG0561	phosphatase activity
YPD4_3376	COG2267	carboxylic ester hydrolase activity
YPD4_3378	COG1280	lysine exporter protein (LysE YggA)
YPD4_3379	COG0514	ATP-dependent DNA helicase (RecQ)
YPD4_3380	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
YPD4_3381	COG2050	protein possibly involved in aromatic compounds catabolism
YPD4_3383	COG0598	Magnesium transport protein CorA
YPD4_3384	COG5564	TIM-barrel signal transduction protein
YPD4_3385	COG5441	Belongs to the UPF0261 family
YPD4_3386	COG5441	Belongs to the UPF0261 family
YPD4_3388	COG0210	DNA helicase
YPD4_3389	COG1011	Hydrolase
YPD4_3390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
YPD4_3391	COG3159	Protein conserved in bacteria
YPD4_3394	COG3072	Adenylate cyclase
YPD4_3396	COG1587	Uroporphyrinogen-III synthase
YPD4_3397	COG2959	enzyme of heme biosynthesis
YPD4_3398	COG3071	HemY protein
YPD4_3400	COG1113	amino acid transport
YPD4_3404	COG2244	polysaccharide biosynthetic process
YPD4_3405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YPD4_3406	COG0456	acetyltransferase
YPD4_3407	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
YPD4_3408	COG1088	dTDP-glucose 4,6-dehydratase activity
YPD4_3409	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
YPD4_3410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
YPD4_3411	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YPD4_3412	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YPD4_3413	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
YPD4_3414	COG3118	belongs to the thioredoxin family
YPD4_3419	COG3328	transposase activity
YPD4_3421	COG3121	Chaperone
YPD4_3424	COG3121	Chaperone
YPD4_3427	COG0583	DNA-binding transcription factor activity
YPD4_3434	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YPD4_3437	COG3085	chromosome segregation
YPD4_3439	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_3440	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_3441	COG1129	ABC transporter
YPD4_3442	COG1879	ABC-type sugar transport system periplasmic component
YPD4_3450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YPD4_3450	COG0678	peroxiredoxin activity
YPD4_3451	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPD4_3456	COG1629	transport
YPD4_3459	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
YPD4_3463	COG2801	Transposase and inactivated derivatives
YPD4_3465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YPD4_3466	COG0058	SHG alpha-glucan phosphorylase activity
YPD4_3468	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
YPD4_3471	COG3275	phosphorelay sensor kinase activity
YPD4_3473	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YPD4_3474	COG2095	MarC family integral membrane protein
YPD4_3476	COG3265	gluconokinase activity
YPD4_3477	COG2610	gluconate transmembrane transporter activity
YPD4_3478	COG1609	Transcriptional regulator
YPD4_3479	COG1741	Belongs to the pirin family
YPD4_3480	COG0745	RESPONSE REGULATOR receiver
YPD4_3482	COG0191	fructose-bisphosphate aldolase activity
YPD4_3484	COG1879	ABC-type sugar transport system periplasmic component
YPD4_3485	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_3488	COG2081	HI0933 family
YPD4_3489	COG0306	phosphate transporter
YPD4_3492	COG0589	response to stress
YPD4_3496	COG0339	signal peptide processing
YPD4_3497	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
YPD4_3498	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPD4_3499	COG3835	regulator
YPD4_3500	COG2610	gluconate transmembrane transporter activity
YPD4_3501	COG1929	Belongs to the glycerate kinase type-1 family
YPD4_3506	COG1295	ribonuclease BN
YPD4_3507	COG2134	cdp-diacylglycerol pyrophosphatase
YPD4_3508	COG2982	Protein involved in outer membrane biogenesis
YPD4_3509	COG2200	EAL domain
YPD4_3510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD4_3511	COG0612	Peptidase, M16
YPD4_3515	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YPD4_3516	COG2200	EAL domain
YPD4_3516	COG2199	diguanylate cyclase activity
YPD4_3517	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
YPD4_3518	COG4608	Belongs to the ABC transporter superfamily
YPD4_3519	COG0444	Belongs to the ABC transporter superfamily
YPD4_3520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPD4_3521	COG0601	transmembrane transport
YPD4_3522	COG0747	negative chemotaxis
YPD4_3523	COG2831	hemolysin activation secretion protein
YPD4_3525	COG2271	Major facilitator Superfamily
YPD4_3529	COG3851	Histidine kinase
YPD4_3530	COG2197	response regulator
YPD4_3531	COG2194	sulfuric ester hydrolase activity
YPD4_3534	COG2986	histidine ammonia-lyase
YPD4_3537	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YPD4_3540	COG4607	ABC-type enterochelin transport system periplasmic component
YPD4_3542	COG4605	iron ion homeostasis
YPD4_3543	COG4604	ABC transporter, ATP-binding protein
YPD4_3547	COG0582	viral genome integration into host DNA
YPD4_3548	COG1609	Transcriptional regulator
YPD4_3548	COG2207	Transcriptional regulator
YPD4_3549	COG4214	carbohydrate transport
YPD4_3551	COG4213	ABC transporter substrate-binding protein
YPD4_3553	COG1070	Carbohydrate kinase
YPD4_3555	COG3121	Chaperone
YPD4_3556	COG3188	usher protein
YPD4_3557	COG3188	usher protein
YPD4_3559	COG3274	enterobacterial common antigen metabolic process
YPD4_3561	COG2801	Transposase and inactivated derivatives
YPD4_3566	COG3276	selenocysteine insertion sequence binding
YPD4_3569	COG2864	formate dehydrogenase
YPD4_3570	COG0437	4 iron, 4 sulfur cluster binding
YPD4_3571	COG0243	molybdopterin cofactor binding
YPD4_3571	COG3383	formate dehydrogenase (NAD+) activity
YPD4_3572	COG3383	formate dehydrogenase (NAD+) activity
YPD4_3572	COG0243	molybdopterin cofactor binding
YPD4_3574	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YPD4_3579	COG3722	fumarate hydratase activity
YPD4_3586	COG2818	Glycosylase
YPD4_3588	COG2885	chlorophyll binding
YPD4_3591	COG0366	Alpha amylase catalytic
YPD4_3593	COG3977	Valine--pyruvate aminotransferase
YPD4_3597	COG5645	(Lipo)protein
YPD4_3598	COG0823	Involved in the tonB-independent uptake of proteins
YPD4_3599	COG0823	Involved in the tonB-independent uptake of proteins
YPD4_3600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YPD4_3601	COG2423	ornithine cyclodeaminase activity
YPD4_3603	COG2801	Transposase and inactivated derivatives
YPD4_3604	COG0561	phosphatase activity
YPD4_3605	COG0187	DNA topoisomerase II activity
YPD4_3606	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YPD4_3607	COG0592	DNA-directed DNA polymerase activity
YPD4_3610	COG0706	membrane insertase activity
YPD4_3614	COG2252	PERMEase
YPD4_3615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPD4_3616	COG0765	amino acid transport
YPD4_3617	COG0765	amino acid transport
YPD4_3618	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_3620	COG0704	Plays a role in the regulation of phosphate uptake
YPD4_3622	COG0581	inorganic phosphate transmembrane transporter activity
YPD4_3623	COG0573	inorganic phosphate transmembrane transporter activity
YPD4_3624	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YPD4_3625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YPD4_3634	COG3312	ion transport
YPD4_pCD0001	COG2801	Transposase and inactivated derivatives
YPD4_pCD0003	COG5599	Phosphatase
YPD4_pCD0005	COG1475	DNA binding
YPD4_pCD0006	COG1192	Involved in chromosome partitioning
YPD4_pCD0007	COG2801	Transposase and inactivated derivatives
YPD4_pCD0011	COG3177	Filamentation induced by cAMP protein fic
YPD4_pCD0015	COG4886	Leucine-rich repeat (LRR) protein
YPD4_pCD0019	COG0457	Tetratricopeptide repeat
YPD4_pCD0022	COG4789	Type iii secretion
YPD4_pCD0030	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
YPD4_pCD0031	COG4790	Type iii secretion
YPD4_pCD0032	COG4791	protein targeting
YPD4_pCD0033	COG4792	protein secretion
YPD4_pCD0035	COG2207	Transcriptional regulator
YPD4_pCD0044	COG4669	(LipO)protein
YPD4_pCD0046	COG1317	bacterial-type flagellum organization
YPD4_pCD0047	COG5599	Phosphatase
YPD4_pCD0048	COG2801	Transposase and inactivated derivatives
YPD4_pCD0050	COG2801	Transposase and inactivated derivatives
YPD4_pCD0052	COG0515	serine threonine protein kinase
YPD4_pCD0059	COG2801	Transposase and inactivated derivatives
YPD4_pCD0064	COG2801	Transposase and inactivated derivatives
YPD4_pMT0003	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
YPD4_pMT0004	COG5301	cellulose 1,4-beta-cellobiosidase activity
YPD4_pMT0004	COG5301	cellulose 1,4-beta-cellobiosidase activity
YPD4_pMT0011	COG3941	tape measure
YPD4_pMT0027	COG1475	DNA binding
YPD4_pMT0028	COG1475	DNA binding
YPD4_pMT0029	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YPD4_pMT0039	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YPD4_pMT0046	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
YPD4_pMT0047	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPD4_pMT0061	COG3328	transposase activity
YPD4_pMT0064	COG3344	reverse transcriptase
YPD4_pMT0066	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YPD4_pMT0076	COG1475	DNA binding
YPD4_pPCP0009	COG4683	PFAM Phage derived protein Gp49-like (DUF891)