locus-tag	class	description
YPD8_0001	COG0716	FMN binding
YPD8_0002	COG1522	sequence-specific DNA binding
YPD8_0008	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD8_0009	COG0477	Major facilitator Superfamily
YPD8_0010	COG2186	Transcriptional regulator
YPD8_0011	COG3328	transposase activity
YPD8_0012	COG3328	transposase activity
YPD8_0013	COG1763	Mo-molybdopterin cofactor biosynthetic process
YPD8_0015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
YPD8_0016	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YPD8_0017	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPD8_0017	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPD8_0018	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPD8_0018	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPD8_0019	COG1943	Transposase
YPD8_0022	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YPD8_0024	COG3852	Histidine kinase
YPD8_0025	COG0174	glutamine synthetase
YPD8_0027	COG1011	Hydrolase
YPD8_0028	COG1295	ribonuclease BN
YPD8_0032	COG0456	acetyltransferase
YPD8_0033	COG2982	Protein involved in outer membrane biogenesis
YPD8_0034	COG2233	PERMEase
YPD8_0035	COG0786	glutamate:sodium symporter activity
YPD8_0036	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YPD8_0037	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPD8_0038	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YPD8_0040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YPD8_0041	COG2860	membrane
YPD8_0042	COG1561	YicC-like family, N-terminal region
YPD8_0047	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YPD8_0048	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YPD8_0053	COG1519	Transferase
YPD8_0054	COG0859	PFAM glycosyl transferase family 9
YPD8_0055	COG0859	PFAM glycosyl transferase family 9
YPD8_0057	COG0156	8-amino-7-oxononanoate synthase activity
YPD8_0059	COG2861	carbohydrate metabolic process
YPD8_0060	COG2861	carbohydrate metabolic process
YPD8_0061	COG4942	peptidase
YPD8_0063	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YPD8_0066	COG1045	serine acetyltransferase
YPD8_0067	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
YPD8_0068	COG2169	Transcriptional regulator
YPD8_0068	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YPD8_0069	COG2205	protein histidine kinase activity
YPD8_0070	COG0745	RESPONSE REGULATOR receiver
YPD8_0071	COG3678	ATP-independent chaperone mediated protein folding
YPD8_0075	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
YPD8_0077	COG0471	metal ion transport
YPD8_0078	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YPD8_0079	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YPD8_0080	COG0583	DNA-binding transcription factor activity
YPD8_0083	COG3152	Membrane
YPD8_0085	COG1494	fructose-1,6-bisphosphatase
YPD8_0086	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YPD8_0087	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YPD8_0088	COG1943	Transposase
YPD8_0093	COG1575	Belongs to the MenA family. Type 1 subfamily
YPD8_0096	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YPD8_0097	COG1609	Transcriptional regulator
YPD8_0098	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YPD8_0099	COG4682	membrane
YPD8_0101	COG0626	cystathionine gamma-synthase activity
YPD8_0102	COG0527	aspartate kinase activity
YPD8_0102	COG0460	homoserine dehydrogenase
YPD8_0104	COG2801	Transposase and inactivated derivatives
YPD8_0106	COG1349	DNA-binding transcription factor activity
YPD8_0108	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YPD8_0113	COG0058	SHG alpha-glucan phosphorylase activity
YPD8_0114	COG0058	SHG alpha-glucan phosphorylase activity
YPD8_0115	COG1640	4-alpha-glucanotransferase
YPD8_0120	COG2183	response to ionizing radiation
YPD8_0121	COG2183	response to ionizing radiation
YPD8_0122	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPD8_0123	COG0745	RESPONSE REGULATOR receiver
YPD8_0127	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
YPD8_0128	COG1011	Hydrolase
YPD8_0130	COG0494	nUDIX hydrolase
YPD8_0131	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
YPD8_0132	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
YPD8_0137	COG4796	Type ii and iii secretion system protein
YPD8_0142	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
YPD8_0143	COG0546	phosphoglycolate phosphatase activity
YPD8_0144	COG0180	Tryptophanyl-tRNA synthetase
YPD8_0147	COG2146	nitrite reductase [NAD(P)H] activity
YPD8_0148	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YPD8_0149	COG0402	S-adenosylhomocysteine deaminase activity
YPD8_0153	COG1486	melibiose metabolic process
YPD8_0154	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YPD8_0155	COG0433	COG0433 Predicted ATPase
YPD8_0158	COG1289	transmembrane transporter activity
YPD8_0160	COG1765	OsmC-like protein
YPD8_0162	COG3954	Phosphoribulokinase
YPD8_0163	COG0429	hydrolase of the alpha beta-hydrolase fold
YPD8_0165	COG4521	taurine ABC transporter
YPD8_0167	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPD8_0168	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPD8_0169	COG2175	clavaminate synthase activity
YPD8_0171	COG1216	Glycosyl transferase, family 2
YPD8_0172	COG0488	(ABC) transporter
YPD8_0173	COG0488	(ABC) transporter
YPD8_0174	COG2249	NAD(P)H dehydrogenase (quinone) activity
YPD8_0176	COG1047	Peptidyl-prolyl cis-trans
YPD8_0177	COG0545	Peptidyl-prolyl cis-trans isomerase
YPD8_0178	COG2964	Protein conserved in bacteria
YPD8_0181	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
YPD8_0182	COG0049	tRNA binding
YPD8_0185	COG1943	Transposase
YPD8_0187	COG0051	transcription antitermination factor activity, RNA binding
YPD8_0193	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YPD8_0194	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YPD8_0195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YPD8_0203	COG0201	protein transport
YPD8_0205	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YPD8_0208	COG0789	Transcriptional regulator
YPD8_0210	COG0569	domain protein
YPD8_0214	COG0758	DNA mediated transformation
YPD8_0216	COG0551	DNA topoisomerase type I activity
YPD8_0219	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YPD8_0224	COG3162	membrane
YPD8_0226	COG1301	dicarboxylic acid transport
YPD8_0243	COG2391	methyltransferase activity
YPD8_0244	COG0583	DNA-binding transcription factor activity
YPD8_0245	COG0814	amino acid
YPD8_0246	COG0626	cystathionine gamma-synthase activity
YPD8_0248	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD8_0249	COG4558	Periplasmic binding protein
YPD8_0250	COG3720	iron ion transport
YPD8_0251	COG4771	TonB-dependent receptor
YPD8_0252	COG0702	epimerase
YPD8_0253	COG3721	Heme iron utilization protein
YPD8_0258	COG1358	cellular component organization or biogenesis
YPD8_0269	COG3121	Chaperone
YPD8_0276	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
YPD8_0278	COG0735	belongs to the Fur family
YPD8_0279	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPD8_0281	COG0305	Participates in initiation and elongation during chromosome replication
YPD8_0282	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YPD8_0283	COG1448	Aminotransferase
YPD8_0284	COG2315	Protein conserved in bacteria
YPD8_0285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YPD8_0286	COG0629	single-stranded DNA binding
YPD8_0288	COG1454	alcohol dehydrogenase
YPD8_0297	COG1309	transcriptional regulator
YPD8_0298	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPD8_0298	COG0493	'glutamate synthase
YPD8_0299	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPD8_0300	COG3383	formate dehydrogenase (NAD+) activity
YPD8_0303	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPD8_0310	COG2076	Multidrug Resistance protein
YPD8_0311	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
YPD8_0313	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
YPD8_0314	COG1053	succinate dehydrogenase
YPD8_0316	COG1511	domain protein
YPD8_0316	COG3264	Mechanosensitive ion channel
YPD8_0319	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
YPD8_0320	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
YPD8_0321	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
YPD8_0321	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YPD8_0322	COG0802	atpase or kinase
YPD8_0323	COG0860	N-Acetylmuramoyl-L-alanine amidase
YPD8_0328	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YPD8_0329	COG0330	HflC and HflK could
YPD8_0330	COG0330	HflC and HflK could
YPD8_0333	COG0557	exoribonuclease II activity
YPD8_0334	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPD8_0335	COG1960	acyl-CoA dehydrogenase activity
YPD8_0338	COG1401	restriction endodeoxyribonuclease activity
YPD8_0346	COG4269	membrane
YPD8_0348	COG2207	Transcriptional regulator
YPD8_0349	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD8_0350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD8_0351	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD8_0352	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD8_0352	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YPD8_0352	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD8_0360	COG2390	Transcriptional regulator
YPD8_0362	COG0859	PFAM glycosyl transferase family 9
YPD8_0364	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD8_0365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPD8_0367	COG3706	GGDEF domain
YPD8_0369	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
YPD8_0370	COG0456	acetyltransferase
YPD8_0372	COG2823	Periplasmic or secreted lipoprotein
YPD8_0373	COG4667	esterase of the alpha-beta hydrolase superfamily
YPD8_0374	COG0084	hydrolase, TatD family'
YPD8_0375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YPD8_0376	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YPD8_0381	COG3726	membrane protein affecting hemolysin expression
YPD8_0382	COG0560	Phosphoserine phosphatase
YPD8_0386	COG0488	(ABC) transporter
YPD8_0387	COG0488	(ABC) transporter
YPD8_0388	COG2885	chlorophyll binding
YPD8_0389	COG2199	diguanylate cyclase activity
YPD8_0392	COG0741	lytic transglycosylase activity
YPD8_0393	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
YPD8_0396	COG3708	Transcriptional regulator
YPD8_0396	COG2207	Transcriptional regulator
YPD8_0397	COG3045	CreA protein
YPD8_0398	COG0745	RESPONSE REGULATOR receiver
YPD8_0404	COG0521	Mo-molybdopterin cofactor biosynthetic process
YPD8_0407	COG1584	GPR1 FUN34 yaaH family protein
YPD8_0411	COG0583	DNA-binding transcription factor activity
YPD8_0412	COG0196	riboflavin kinase activity
YPD8_0413	COG0196	riboflavin kinase activity
YPD8_0416	COG1047	Peptidyl-prolyl cis-trans
YPD8_0418	COG1943	Transposase
YPD8_0420	COG0505	Belongs to the CarA family
YPD8_0421	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
YPD8_0422	COG1280	lysine exporter protein (LysE YggA)
YPD8_0423	COG2966	Psort location CytoplasmicMembrane, score
YPD8_0425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
YPD8_0426	COG1943	Transposase
YPD8_0431	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
YPD8_0432	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YPD8_0434	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
YPD8_0435	COG0564	pseudouridine synthase activity
YPD8_0445	COG3501	Rhs element vgr protein
YPD8_0452	COG2885	chlorophyll binding
YPD8_0452	COG3047	cAMP biosynthetic process
YPD8_0456	COG0417	DNA replication proofreading
YPD8_0457	COG0586	Pfam SNARE associated Golgi protein
YPD8_0459	COG1178	ABC-type Fe3 transport system permease component
YPD8_0460	COG4143	(ABC) transporter
YPD8_0462	COG2814	Major facilitator Superfamily
YPD8_0467	COG0473	3-isopropylmalate dehydrogenase activity
YPD8_0469	COG1943	Transposase
YPD8_0471	COG1022	Amp-dependent synthetase and ligase
YPD8_0472	COG0028	Belongs to the TPP enzyme family
YPD8_0474	COG1943	Transposase
YPD8_0475	COG1609	Transcriptional regulator
YPD8_0479	COG3116	cell division
YPD8_0480	COG0768	penicillin binding
YPD8_0481	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YPD8_0482	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YPD8_0483	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YPD8_0486	COG0772	Belongs to the SEDS family
YPD8_0490	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
YPD8_0491	COG0849	cell division
YPD8_0492	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
YPD8_0497	COG0494	nUDIX hydrolase
YPD8_0500	COG2259	Doxx family
YPD8_0501	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
YPD8_0502	COG4575	ribosome binding
YPD8_0505	COG0586	Pfam SNARE associated Golgi protein
YPD8_0508	COG2271	Major facilitator Superfamily
YPD8_0510	COG0246	Mannitol dehydrogenase
YPD8_0511	COG2721	sulfolactate sulfo-lyase activity
YPD8_0513	COG1943	Transposase
YPD8_0515	COG0673	inositol 2-dehydrogenase activity
YPD8_0516	COG1451	nucleotide metabolic process
YPD8_0519	COG1902	pentaerythritol trinitrate reductase activity
YPD8_0519	COG0446	pyridine nucleotide-disulphide oxidoreductase
YPD8_0520	COG3247	response to pH
YPD8_0523	COG4245	von Willebrand factor, type A
YPD8_0526	COG4245	von Willebrand factor, type A
YPD8_0527	COG2831	hemolysin activation secretion protein
YPD8_0528	COG3210	domain, Protein
YPD8_0529	COG3210	domain, Protein
YPD8_0533	COG3842	ATPase activity
YPD8_0534	COG3459	Glycosyltransferase 36 associated
YPD8_0535	COG1609	Transcriptional regulator
YPD8_0536	COG1653	transport
YPD8_0538	COG0395	ABC-type sugar transport system, permease component
YPD8_0542	COG1289	transmembrane transporter activity
YPD8_0548	COG0251	oxidation-reduction process
YPD8_0557	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YPD8_0558	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YPD8_0559	COG0358	DNA primase activity
YPD8_0562	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
YPD8_0565	COG4991	sh3 domain protein
YPD8_0566	COG3025	triphosphatase activity
YPD8_0569	COG0531	amino acid
YPD8_0571	COG3384	dioxygenase
YPD8_0572	COG0754	glutathionylspermidine amidase activity
YPD8_0574	COG1538	Outer membrane efflux protein
YPD8_0575	COG0494	nUDIX hydrolase
YPD8_0576	COG3151	Protein conserved in bacteria
YPD8_0577	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YPD8_0578	COG3150	esterase
YPD8_0579	COG0187	DNA topoisomerase II activity
YPD8_0580	COG0583	DNA-binding transcription factor activity
YPD8_0581	COG2249	NAD(P)H dehydrogenase (quinone) activity
YPD8_0582	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YPD8_0583	COG0204	Acyl-transferase
YPD8_0584	COG2132	Multicopper oxidase
YPD8_0587	COG0656	L-ascorbic acid biosynthetic process
YPD8_0588	COG1979	alcohol dehydrogenase
YPD8_0589	COG2207	Transcriptional regulator
YPD8_0590	COG0586	Pfam SNARE associated Golgi protein
YPD8_0591	COG0626	cystathionine gamma-synthase activity
YPD8_0592	COG0811	peptide transport
YPD8_0593	COG0848	biopolymer transport protein
YPD8_0602	COG4964	Belongs to the GSP D family
YPD8_0603	COG4964	Belongs to the GSP D family
YPD8_0606	COG1943	Transposase
YPD8_0607	COG1943	Transposase
YPD8_0611	COG4592	Periplasmic binding protein
YPD8_0615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPD8_0616	COG1684	flagellar biosynthetic protein fliR
YPD8_0620	COG2204	response regulator
YPD8_0628	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
YPD8_0629	COG1815	bacterial-type flagellum-dependent cell motility
YPD8_0630	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
YPD8_0631	COG1749	Flagellar hook protein flgE
YPD8_0632	COG1749	Flagellar hook protein flgE
YPD8_0633	COG1943	Transposase
YPD8_0635	COG4786	Flagellar basal body rod
YPD8_0636	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
YPD8_0637	COG1706	bacterial-type flagellum-dependent cell motility
YPD8_0638	COG1256	bacterial-type flagellum assembly
YPD8_0642	COG3710	Transcriptional regulator
YPD8_0646	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
YPD8_0651	COG1191	sigma factor activity
YPD8_0652	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
YPD8_0657	COG2801	Transposase and inactivated derivatives
YPD8_0660	COG0471	metal ion transport
YPD8_0662	COG3209	COG3209 Rhs family protein
YPD8_0664	COG3501	Rhs element vgr protein
YPD8_0665	COG3501	Rhs element vgr protein
YPD8_0669	COG2610	gluconate transmembrane transporter activity
YPD8_0672	COG1132	(ABC) transporter
YPD8_0678	COG3433	isochorismatase activity
YPD8_0678	COG2226	methyltransferase
YPD8_0678	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPD8_0679	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPD8_0680	COG3433	isochorismatase activity
YPD8_0680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPD8_0680	COG2226	methyltransferase
YPD8_0684	COG4771	TonB-dependent receptor
YPD8_0685	COG2195	Cleaves the N-terminal amino acid of tripeptides
YPD8_0686	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
YPD8_0694	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD8_0695	COG3300	MHYT domain
YPD8_0695	COG5001	Diguanylate cyclase
YPD8_0696	COG2801	Transposase and inactivated derivatives
YPD8_0698	COG2211	Major facilitator Superfamily
YPD8_0708	COG2771	luxR family
YPD8_0709	COG3916	Acyl-homoserine-lactone synthase
YPD8_0721	COG1982	Orn Lys Arg decarboxylase major
YPD8_0722	COG1879	ABC-type sugar transport system periplasmic component
YPD8_0723	COG1129	ABC transporter
YPD8_0724	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_0725	COG4774	siderophore transport
YPD8_0728	COG1194	a g-specific adenine glycosylase
YPD8_0730	COG3171	Protein conserved in bacteria
YPD8_0731	COG2066	Belongs to the glutaminase family
YPD8_0733	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
YPD8_0733	COG3064	Membrane
YPD8_0733	COG1073	alpha beta
YPD8_0734	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YPD8_0735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
YPD8_0736	COG0762	integral membrane protein
YPD8_0737	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
YPD8_0738	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
YPD8_0739	COG2805	Type II/IV secretion system protein
YPD8_0741	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPD8_0744	COG0189	ligase activity
YPD8_0745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
YPD8_0746	COG2356	endonuclease I
YPD8_0749	COG1166	arginine decarboxylase activity
YPD8_0751	COG0501	Belongs to the peptidase M48B family
YPD8_0752	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
YPD8_0753	COG1943	Transposase
YPD8_0756	COG0191	fructose-bisphosphate aldolase activity
YPD8_0761	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YPD8_0762	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YPD8_0763	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YPD8_0766	COG0006	proline dipeptidase activity
YPD8_0767	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPD8_0768	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPD8_0773	COG5295	Hep Hag repeat protein
YPD8_0773	COG5295	Hep Hag repeat protein
YPD8_0775	COG1272	protein, Hemolysin III
YPD8_0779	COG0745	RESPONSE REGULATOR receiver
YPD8_0780	COG2205	protein histidine kinase activity
YPD8_0781	COG4452	Inner membrane protein CreD
YPD8_0782	COG0716	FMN binding
YPD8_0783	COG4974	Belongs to the 'phage' integrase family
YPD8_0784	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YPD8_0785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
YPD8_0788	COG0582	viral genome integration into host DNA
YPD8_0790	COG2944	sequence-specific DNA binding
YPD8_0801	COG1695	Transcriptional regulator
YPD8_0802	COG0791	NLP P60 protein
YPD8_0804	COG1879	ABC-type sugar transport system periplasmic component
YPD8_0805	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_0806	COG1129	ABC transporter
YPD8_0808	COG2182	Extracellular solute-binding protein
YPD8_0809	COG2182	Extracellular solute-binding protein
YPD8_0810	COG1175	transmembrane transport
YPD8_0811	COG3833	ABC-type maltose transport systems, permease component
YPD8_0812	COG3867	Arabinogalactan endo-beta-1,4-galactanase
YPD8_0813	COG1874	Beta-galactosidase
YPD8_0814	COG1263	PTS System
YPD8_0814	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD8_0819	COG2271	Major facilitator Superfamily
YPD8_0822	COG0191	fructose-bisphosphate aldolase activity
YPD8_0824	COG3119	arylsulfatase activity
YPD8_0825	COG0641	radical SAM
YPD8_0827	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_0829	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD8_0830	COG3716	PTS system mannose fructose sorbose family IID component
YPD8_0831	COG3715	PTS system
YPD8_0832	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD8_0833	COG2222	sugar isomerase
YPD8_0834	COG2222	sugar isomerase
YPD8_0836	COG1349	DNA-binding transcription factor activity
YPD8_0837	COG3119	arylsulfatase activity
YPD8_0838	COG1943	Transposase
YPD8_0839	COG1943	Transposase
YPD8_0846	COG0288	reversible hydration of carbon dioxide
YPD8_0860	COG0840	transmembrane signaling receptor activity
YPD8_0863	COG0583	DNA-binding transcription factor activity
YPD8_0864	COG2814	Major facilitator Superfamily
YPD8_0865	COG0583	DNA-binding transcription factor activity
YPD8_0866	COG0019	diaminopimelate decarboxylase activity
YPD8_0867	COG1609	Transcriptional regulator
YPD8_0872	COG0667	Aldo Keto reductase
YPD8_0881	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD8_0882	COG1943	Transposase
YPD8_0883	COG3009	Protein conserved in bacteria
YPD8_0884	COG3008	intermembrane lipid transfer
YPD8_0884	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YPD8_0885	COG2995	paraquat-inducible protein a
YPD8_0886	COG0488	(ABC) transporter
YPD8_0888	COG3217	Mosc domain protein beta barrel domain protein
YPD8_0888	COG0633	Ferredoxin
YPD8_0891	COG0308	aminopeptidase N
YPD8_0895	COG1448	Aminotransferase
YPD8_0896	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YPD8_0897	COG3108	Peptidase M15
YPD8_0898	COG2989	Protein conserved in bacteria
YPD8_0899	COG1943	Transposase
YPD8_0901	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
YPD8_0902	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
YPD8_0903	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YPD8_0904	COG3173	Aminoglycoside phosphotransferase
YPD8_0906	COG5383	Protein conserved in bacteria
YPD8_0909	COG0658	competence protein
YPD8_0909	COG2333	competence protein COMEC
YPD8_0910	COG0539	negative regulation of cytoplasmic translation
YPD8_0915	COG5295	Hep Hag repeat protein
YPD8_0915	COG5295	Hep Hag repeat protein
YPD8_0916	COG0252	asparaginase activity
YPD8_0917	COG1944	ATP diphosphatase activity
YPD8_0918	COG2116	formate transmembrane transporter activity
YPD8_0919	COG1882	Formate acetyltransferase
YPD8_0921	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
YPD8_0922	COG2814	Major facilitator Superfamily
YPD8_0924	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YPD8_0926	COG1674	ftsk spoiiie
YPD8_0926	COG3107	peptidoglycan biosynthetic process
YPD8_0928	COG0492	ferredoxin-NADP+ reductase activity
YPD8_0930	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
YPD8_0932	COG1943	Transposase
YPD8_0933	COG0542	response to heat
YPD8_0936	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD8_0937	COG2990	Protein conserved in bacteria
YPD8_0938	COG3593	DNA synthesis involved in DNA repair
YPD8_0939	COG2431	L-lysine efflux transmembrane transporter activity
YPD8_0941	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD8_0942	COG0028	Belongs to the TPP enzyme family
YPD8_0943	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
YPD8_0944	COG0702	epimerase
YPD8_0945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD8_0947	COG1605	Chorismate mutase
YPD8_0948	COG1126	abc transporter atp-binding protein
YPD8_0949	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD8_0950	COG4215	(ABC) transporter
YPD8_0951	COG4160	amino acid transport
YPD8_0955	COG1120	ATPase activity
YPD8_0957	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD8_0960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD8_0963	COG1177	transmembrane transport
YPD8_0964	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPD8_0965	COG3842	ATPase activity
YPD8_0966	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
YPD8_0969	COG2985	domain, Protein
YPD8_0969	COG0569	domain protein
YPD8_0971	COG0671	phosphoesterase, PA-phosphatase related
YPD8_0972	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YPD8_0973	COG1349	DNA-binding transcription factor activity
YPD8_0974	COG0814	amino acid
YPD8_0975	COG1686	Belongs to the peptidase S11 family
YPD8_0976	COG2011	ABC-type metal ion transport system permease component
YPD8_0981	COG0625	glutathione transferase activity
YPD8_0982	COG4771	TonB-dependent receptor
YPD8_0984	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD8_0987	COG0833	amino acid
YPD8_0988	COG0583	DNA-binding transcription factor activity
YPD8_0989	COG2855	membrane
YPD8_0991	COG3188	usher protein
YPD8_0992	COG3121	Chaperone
YPD8_0995	COG3710	Transcriptional regulator
YPD8_0996	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD8_0996	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD8_0996	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
YPD8_0997	COG1105	Belongs to the carbohydrate kinase PfkB family
YPD8_0999	COG0494	nUDIX hydrolase
YPD8_1000	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_1001	COG1129	ABC transporter
YPD8_1003	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YPD8_1008	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_1011	COG1312	Catalyzes the dehydration of D-mannonate
YPD8_1012	COG0246	Mannitol dehydrogenase
YPD8_1013	COG2186	Transcriptional regulator
YPD8_1014	COG0523	cobalamin synthesis protein
YPD8_1015	COG0671	phosphoesterase, PA-phosphatase related
YPD8_1016	COG0791	NLP P60 protein
YPD8_1017	COG2200	EAL domain
YPD8_1018	COG4166	transmembrane transport
YPD8_1019	COG4174	ABC transporter (Permease)
YPD8_1020	COG4239	(ABC) transporter, permease
YPD8_1021	COG4172	Belongs to the ABC transporter superfamily
YPD8_1023	COG2814	Major facilitator Superfamily
YPD8_1024	COG1187	pseudouridine synthase activity
YPD8_1025	COG1061	Type III restriction enzyme res subunit
YPD8_1026	COG1943	Transposase
YPD8_1029	COG3083	sulfuric ester hydrolase activity
YPD8_1031	COG3157	Type VI secretion system effector, Hcp
YPD8_1034	COG2723	6-phospho-beta-galactosidase activity
YPD8_1035	COG1737	Transcriptional regulator
YPD8_1038	COG3299	homolog of phage Mu protein gp47
YPD8_1046	COG4386	tail sheath protein
YPD8_1048	COG3622	Belongs to the hyi family
YPD8_1049	COG1349	DNA-binding transcription factor activity
YPD8_1050	COG0235	Class ii aldolase
YPD8_1051	COG3395	kinase activity
YPD8_1058	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
YPD8_1059	COG1943	Transposase
YPD8_1060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
YPD8_1061	COG2223	nitrite transmembrane transporter activity
YPD8_1062	COG0642	Histidine kinase
YPD8_1062	COG2198	Histidine kinase
YPD8_1063	COG2198	Histidine kinase
YPD8_1063	COG0642	Histidine kinase
YPD8_1065	COG2205	protein histidine kinase activity
YPD8_1065	COG0784	Response regulator, receiver
YPD8_1072	COG0814	amino acid
YPD8_1077	COG0697	spore germination
YPD8_1078	COG1982	Orn Lys Arg decarboxylase major
YPD8_1079	COG0531	amino acid
YPD8_1080	COG1174	glycine betaine transport
YPD8_1081	COG1125	glycine betaine transport
YPD8_1082	COG1174	glycine betaine transport
YPD8_1083	COG1732	Glycine betaine
YPD8_1084	COG1732	Glycine betaine
YPD8_1085	COG2897	thiosulfate sulfurtransferase activity
YPD8_1088	COG0410	ABC transporter
YPD8_1089	COG1122	ATPase activity
YPD8_1093	COG4807	Protein conserved in bacteria
YPD8_1096	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
YPD8_1099	COG1403	HNH endonuclease
YPD8_1101	COG0277	FAD linked oxidase domain protein
YPD8_1102	COG1686	Belongs to the peptidase S11 family
YPD8_1103	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPD8_1105	COG1943	Transposase
YPD8_1106	COG2211	Major facilitator Superfamily
YPD8_1107	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
YPD8_1109	COG0583	DNA-binding transcription factor activity
YPD8_1110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YPD8_1114	COG1943	Transposase
YPD8_1115	COG0670	Belongs to the BI1 family
YPD8_1116	COG0314	molybdopterin synthase activity
YPD8_1118	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YPD8_1119	COG0391	Required for morphogenesis under gluconeogenic growth conditions
YPD8_1120	COG0556	nucleotide-excision repair
YPD8_1122	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YPD8_1123	COG2226	methyltransferase
YPD8_1129	COG0561	phosphatase activity
YPD8_1131	COG4149	molybdate abc transporter
YPD8_1132	COG0725	ABC transporter, periplasmic molybdate-binding protein
YPD8_1133	COG3585	molybdate ion transport
YPD8_1133	COG2005	Transcriptional regulator
YPD8_1134	COG1119	ATPase activity
YPD8_1136	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YPD8_1137	COG1085	galactose-1-phosphate uridylyltransferase
YPD8_1139	COG2017	converts alpha-aldose to the beta-anomer
YPD8_1144	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YPD8_1145	COG1230	cation diffusion facilitator family transporter
YPD8_1148	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
YPD8_1149	COG2885	chlorophyll binding
YPD8_1151	COG3064	Membrane
YPD8_1153	COG0848	biopolymer transport protein
YPD8_1154	COG0811	peptide transport
YPD8_1155	COG3790	cyd operon protein YbgE
YPD8_1156	COG1294	oxidase, subunit
YPD8_1157	COG1271	oxidase subunit
YPD8_1158	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
YPD8_1160	COG0508	dehydrogenase complex catalyzes the overall conversion of
YPD8_1161	COG0567	Dehydrogenase, E1 component
YPD8_1163	COG1053	succinate dehydrogenase
YPD8_1164	COG1053	succinate dehydrogenase
YPD8_1165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
YPD8_1166	COG0372	Belongs to the citrate synthase family
YPD8_1168	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YPD8_1169	COG0497	DNA recombination
YPD8_1170	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPD8_1171	COG2867	negative regulation of translational initiation
YPD8_1173	COG1943	Transposase
YPD8_1174	COG0582	viral genome integration into host DNA
YPD8_1186	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
YPD8_1188	COG1074	ATP-dependent DNA helicase activity
YPD8_1189	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
YPD8_1191	COG0860	N-Acetylmuramoyl-L-alanine amidase
YPD8_1192	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
YPD8_1193	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
YPD8_1194	COG2166	iron-sulfur cluster assembly
YPD8_1195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YPD8_1196	COG0583	DNA-binding transcription factor activity
YPD8_1197	COG2363	Small membrane protein
YPD8_1199	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPD8_1200	COG1611	Belongs to the LOG family
YPD8_1203	COG1943	Transposase
YPD8_1204	COG3098	single-species biofilm formation
YPD8_1205	COG0564	pseudouridine synthase activity
YPD8_1210	COG0024	Methionine aminopeptidase
YPD8_1216	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
YPD8_1217	COG0575	Belongs to the CDS family
YPD8_1218	COG0750	zinc metalloprotease
YPD8_1220	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
YPD8_1224	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YPD8_1226	COG0587	DNA-directed DNA polymerase activity
YPD8_1228	COG0346	lactoylglutathione lyase activity
YPD8_1229	COG0037	tRNA processing
YPD8_1230	COG0037	tRNA processing
YPD8_1232	COG4681	YaeQ
YPD8_1234	COG3015	lipoprotein NlpE involved in copper resistance
YPD8_1236	COG1720	tRNA m6t6A37 methyltransferase activity
YPD8_1238	COG1464	Belongs to the NlpA lipoprotein family
YPD8_1239	COG2011	ABC-type metal ion transport system permease component
YPD8_1241	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YPD8_1242	COG0656	L-ascorbic acid biosynthetic process
YPD8_1245	COG0741	lytic transglycosylase activity
YPD8_1245	COG1388	LysM domain
YPD8_1246	COG1388	LysM domain
YPD8_1246	COG0741	lytic transglycosylase activity
YPD8_1248	COG2226	methyltransferase
YPD8_1250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YPD8_1251	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YPD8_1252	COG1953	Uracil, thiamine, allantoin
YPD8_1253	COG1953	Uracil, thiamine, allantoin
YPD8_1256	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD8_1258	COG1067	ATP-dependent peptidase activity
YPD8_1260	COG1943	Transposase
YPD8_1261	COG2885	chlorophyll binding
YPD8_1261	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
YPD8_1263	COG3070	regulator of competence-specific genes
YPD8_1264	COG1289	transmembrane transporter activity
YPD8_1265	COG3304	Inner membrane component domain
YPD8_1266	COG0210	DNA helicase
YPD8_1268	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
YPD8_1269	COG1832	CoA-binding protein
YPD8_1272	COG2920	part of a sulfur-relay system
YPD8_1276	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_1277	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YPD8_1278	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD8_1279	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_1280	COG3425	synthase
YPD8_1282	COG1024	Enoyl-CoA hydratase
YPD8_1283	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_1285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YPD8_1297	COG1662	PFAM IS1 transposase
YPD8_1314	COG0488	(ABC) transporter
YPD8_1316	COG3328	transposase activity
YPD8_1317	COG1607	acyl-coa hydrolase
YPD8_1322	COG3047	cAMP biosynthetic process
YPD8_1326	COG0134	indole-3-glycerol-phosphate synthase activity
YPD8_1326	COG0135	phosphoribosylanthranilate isomerase activity
YPD8_1328	COG0512	Glutamine amidotransferase of anthranilate synthase
YPD8_1331	COG0009	L-threonylcarbamoyladenylate synthase
YPD8_1332	COG1187	pseudouridine synthase activity
YPD8_1333	COG1187	pseudouridine synthase activity
YPD8_1335	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_1336	COG0616	signal peptide processing
YPD8_1337	COG0616	signal peptide processing
YPD8_1338	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YPD8_1339	COG0583	DNA-binding transcription factor activity
YPD8_1341	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
YPD8_1342	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
YPD8_1343	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YPD8_1344	COG0671	phosphoesterase, PA-phosphatase related
YPD8_1345	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
YPD8_1346	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
YPD8_1349	COG0023	Translation Initiation Factor
YPD8_1351	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YPD8_1352	COG2879	small protein
YPD8_1353	COG1966	Carbon starvation protein
YPD8_1355	COG2271	Major facilitator Superfamily
YPD8_1356	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD8_1357	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YPD8_1359	COG4659	FMN binding
YPD8_1360	COG4658	electron transport chain
YPD8_1361	COG2207	Transcriptional regulator
YPD8_1361	COG3708	Transcriptional regulator
YPD8_1368	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD8_1369	COG2274	protein secretion by the type I secretion system
YPD8_1372	COG1879	ABC-type sugar transport system periplasmic component
YPD8_1374	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_1376	COG0673	inositol 2-dehydrogenase activity
YPD8_1377	COG0385	Bile acid
YPD8_1379	COG5339	Protein conserved in bacteria
YPD8_1381	COG0114	fumarate hydratase activity
YPD8_1382	COG0114	fumarate hydratase activity
YPD8_1384	COG2814	Major facilitator Superfamily
YPD8_1385	COG0583	DNA-binding transcription factor activity
YPD8_1386	COG1940	carbohydrate kinase activity
YPD8_1387	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YPD8_1388	COG0038	chloride channel
YPD8_1389	COG1609	Transcriptional regulator
YPD8_1391	COG1879	ABC-type sugar transport system periplasmic component
YPD8_1392	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YPD8_1393	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPD8_1394	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YPD8_1399	COG0028	Belongs to the TPP enzyme family
YPD8_1400	COG0440	acetolactate synthase activity
YPD8_1401	COG1011	Hydrolase
YPD8_1405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YPD8_1406	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YPD8_1407	COG0589	response to stress
YPD8_1408	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
YPD8_1409	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
YPD8_1411	COG0531	amino acid
YPD8_1413	COG0745	RESPONSE REGULATOR receiver
YPD8_1414	COG2205	protein histidine kinase activity
YPD8_1415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
YPD8_1416	COG1943	Transposase
YPD8_1419	COG3038	cytochrome b561
YPD8_1420	COG3591	Belongs to the peptidase S1B family
YPD8_1423	COG1643	Atp-dependent helicase
YPD8_1425	COG2390	Transcriptional regulator
YPD8_1426	COG0246	Mannitol dehydrogenase
YPD8_1427	COG3784	Protein of unknown function (DUF1318)
YPD8_1428	COG2911	Protein conserved in bacteria
YPD8_1429	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YPD8_1430	COG3187	Heat shock protein
YPD8_1431	COG3042	response to heat
YPD8_1432	COG1285	pathogenesis
YPD8_1434	COG1013	pyruvate-flavodoxin oxidoreductase activity
YPD8_1434	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPD8_1434	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YPD8_1434	COG0674	pyruvate-flavodoxin oxidoreductase activity
YPD8_1436	COG0657	acetylesterase activity
YPD8_1436	COG2755	lipolytic protein G-D-S-L family
YPD8_1439	COG4166	transmembrane transport
YPD8_1440	COG2866	Carboxypeptidase
YPD8_1441	COG4948	Mandelate Racemase Muconate Lactonizing
YPD8_1442	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
YPD8_1445	COG1943	Transposase
YPD8_1450	COG3106	COG3106 Predicted ATPase
YPD8_1451	COG1983	PspC domain protein
YPD8_1452	COG1842	Phage shock protein A
YPD8_1453	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
YPD8_1454	COG1943	Transposase
YPD8_1455	COG4166	transmembrane transport
YPD8_1456	COG4168	peptide transport system, permease
YPD8_1457	COG4171	peptide transport system, permease
YPD8_1459	COG4172	Belongs to the ABC transporter superfamily
YPD8_1460	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPD8_1460	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPD8_1461	COG3104	oligopeptide transport
YPD8_1463	COG0625	glutathione transferase activity
YPD8_1467	COG3895	Periplasmic Protein
YPD8_1469	COG3133	Outer membrane lipoprotein
YPD8_1471	COG4989	oxidoreductase activity
YPD8_1472	COG2194	sulfuric ester hydrolase activity
YPD8_1473	COG1309	transcriptional regulator
YPD8_1474	COG1902	pentaerythritol trinitrate reductase activity
YPD8_1476	COG0346	lactoylglutathione lyase activity
YPD8_1477	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YPD8_1478	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
YPD8_1479	COG0791	NLP P60 protein
YPD8_1480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YPD8_1483	COG0583	DNA-binding transcription factor activity
YPD8_1484	COG2814	Major facilitator Superfamily
YPD8_1485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YPD8_1486	COG0307	riboflavin synthase, alpha
YPD8_1489	COG1943	Transposase
YPD8_1492	COG1388	LysM domain
YPD8_1492	COG1376	ErfK ybiS ycfS ynhG family protein
YPD8_1495	COG0719	Fe-S assembly protein
YPD8_1496	COG0396	ATPase activity
YPD8_1497	COG0719	Fe-S assembly protein
YPD8_1498	COG0316	Belongs to the HesB IscA family
YPD8_1499	COG2050	protein possibly involved in aromatic compounds catabolism
YPD8_1500	COG0277	FAD linked oxidase domain protein
YPD8_1500	COG0247	lactate metabolic process
YPD8_1501	COG0628	permease
YPD8_1502	COG0574	Belongs to the PEP-utilizing enzyme family
YPD8_1502	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YPD8_1508	COG0791	NLP P60 protein
YPD8_1516	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
YPD8_1517	COG0386	Belongs to the glutathione peroxidase family
YPD8_1520	COG1943	Transposase
YPD8_1521	COG0072	phenylalanine-tRNA ligase activity
YPD8_1521	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YPD8_1522	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
YPD8_1528	COG0803	Belongs to the bacterial solute-binding protein 9 family
YPD8_1529	COG1121	(ABC) transporter
YPD8_1530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPD8_1531	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPD8_1534	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPD8_1535	COG3328	transposase activity
YPD8_1536	COG2223	nitrite transmembrane transporter activity
YPD8_1539	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YPD8_1543	COG3122	Protein conserved in bacteria
YPD8_1547	COG0534	Mate efflux family protein
YPD8_1550	COG4948	Mandelate Racemase Muconate Lactonizing
YPD8_1552	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_1553	COG3011	Protein conserved in bacteria
YPD8_1554	COG2271	Major facilitator Superfamily
YPD8_1555	COG4932	domain protein
YPD8_1555	COG2373	Large extracellular alpha-helical protein
YPD8_1555	COG1388	LysM domain
YPD8_1556	COG3328	transposase activity
YPD8_1559	COG2925	Exonuclease
YPD8_1560	COG0531	amino acid
YPD8_1561	COG0371	Dehydrogenase
YPD8_1562	COG1129	ABC transporter
YPD8_1563	COG1129	ABC transporter
YPD8_1564	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_1566	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD8_1568	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
YPD8_1570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YPD8_1570	COG0131	Imidazoleglycerol-phosphate dehydratase
YPD8_1571	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
YPD8_1574	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YPD8_1574	COG0140	phosphoribosyl-ATP diphosphatase activity
YPD8_1576	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YPD8_1577	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YPD8_1581	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YPD8_1582	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD8_1583	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD8_1584	COG1120	ATPase activity
YPD8_1587	COG3486	L-lysine 6-monooxygenase (NADPH) activity
YPD8_1588	COG0076	glutamate decarboxylase activity
YPD8_1589	COG4114	ferric iron reductase
YPD8_1590	COG1253	flavin adenine dinucleotide binding
YPD8_1591	COG2982	Protein involved in outer membrane biogenesis
YPD8_1594	COG0489	protein tyrosine kinase activity
YPD8_1596	COG1943	Transposase
YPD8_1600	COG2814	Major facilitator Superfamily
YPD8_1602	COG1346	cytolysis
YPD8_1605	COG2949	membrane
YPD8_1606	COG4211	Belongs to the binding-protein-dependent transport system permease family
YPD8_1609	COG2311	Membrane
YPD8_1611	COG0477	Major facilitator Superfamily
YPD8_1612	COG0583	DNA-binding transcription factor activity
YPD8_1617	COG1136	(ABC) transporter
YPD8_1619	COG0303	'Molybdopterin
YPD8_1621	COG3328	transposase activity
YPD8_1622	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
YPD8_1626	COG4608	Belongs to the ABC transporter superfamily
YPD8_1627	COG0444	Belongs to the ABC transporter superfamily
YPD8_1628	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPD8_1629	COG0601	transmembrane transport
YPD8_1631	COG2095	MarC family integral membrane protein
YPD8_1632	COG1454	alcohol dehydrogenase
YPD8_1632	COG1012	belongs to the aldehyde dehydrogenase family
YPD8_1635	COG1435	thymidine kinase activity
YPD8_1638	COG0745	RESPONSE REGULATOR receiver
YPD8_1640	COG0788	formyltetrahydrofolate deformylase activity
YPD8_1641	COG3328	transposase activity
YPD8_1642	COG0583	DNA-binding transcription factor activity
YPD8_1643	COG0708	Exodeoxyribonuclease III
YPD8_1644	COG0494	nUDIX hydrolase
YPD8_1645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YPD8_1646	COG0709	Synthesizes selenophosphate from selenide and ATP
YPD8_1647	COG0778	Nitroreductase
YPD8_1648	COG0616	signal peptide processing
YPD8_1649	COG0252	asparaginase activity
YPD8_1650	COG1335	isochorismatase
YPD8_1654	COG3713	MltA-interacting MipA family protein
YPD8_1655	COG2766	serine protein kinase
YPD8_1658	COG0583	DNA-binding transcription factor activity
YPD8_1660	COG2814	Major facilitator Superfamily
YPD8_1662	COG2719	SpoVR family
YPD8_1668	COG1104	cysteine desulfurase activity
YPD8_1670	COG3328	transposase activity
YPD8_1681	COG1943	Transposase
YPD8_1696	COG3328	transposase activity
YPD8_1697	COG3328	transposase activity
YPD8_1709	COG0582	viral genome integration into host DNA
YPD8_1711	COG0179	Fumarylacetoacetate (FAA) hydrolase
YPD8_1712	COG2951	lytic endotransglycosylase activity
YPD8_1714	COG2894	cell division
YPD8_1715	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
YPD8_1716	COG0318	PFAM AMP-dependent synthetase and ligase
YPD8_1717	COG3065	identical protein binding
YPD8_1719	COG1199	ATP-dependent helicase activity
YPD8_1720	COG0251	oxidation-reduction process
YPD8_1723	COG0800	Aldolase
YPD8_1724	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YPD8_1725	COG1737	Transcriptional regulator
YPD8_1726	COG0469	pyruvate kinase activity
YPD8_1727	COG1560	Kdo2-lipid A biosynthetic process
YPD8_1728	COG0739	heme binding
YPD8_1729	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
YPD8_1731	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPD8_1736	COG0494	nUDIX hydrolase
YPD8_1738	COG1801	Protein of unknown function DUF72
YPD8_1739	COG3788	relative of glutathione S-transferase, MAPEG superfamily
YPD8_1743	COG3102	Protein conserved in bacteria
YPD8_1747	COG0728	peptidoglycan biosynthetic process
YPD8_1749	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPD8_1752	COG3381	protein complex oligomerization
YPD8_1754	COG1940	carbohydrate kinase activity
YPD8_1755	COG0584	glycerophosphoryl diester phosphodiesterase
YPD8_1756	COG3842	ATPase activity
YPD8_1757	COG1943	Transposase
YPD8_1759	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPD8_1760	COG3833	ABC-type maltose transport systems, permease component
YPD8_1763	COG0659	secondary active sulfate transmembrane transporter activity
YPD8_1765	COG2912	Transglutaminase-like superfamily
YPD8_1766	COG3094	Invasion gene expression up-regulator, SirB
YPD8_1767	COG2890	protein-(glutamine-N5) methyltransferase activity
YPD8_1772	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YPD8_1774	COG0012	GTP binding
YPD8_1784	COG5002	protein histidine kinase activity
YPD8_1792	COG0500	methyltransferase
YPD8_1796	COG3328	transposase activity
YPD8_1805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD8_1806	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YPD8_1807	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YPD8_1810	COG0402	S-adenosylhomocysteine deaminase activity
YPD8_1822	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YPD8_1823	COG3850	Histidine kinase
YPD8_1824	COG0387	Pfam Sodium calcium exchanger
YPD8_1825	COG1702	phosphate starvation-inducible protein PhoH
YPD8_1827	COG3658	cytochrome
YPD8_1828	COG1215	transferase activity, transferring glycosyl groups
YPD8_1829	COG0726	polysaccharide deacetylase
YPD8_1829	COG1649	PFAM Uncharacterised BCR, COG1649
YPD8_1830	COG0457	Tetratricopeptide repeat
YPD8_1831	COG0006	proline dipeptidase activity
YPD8_1835	COG0577	efflux transmembrane transporter activity
YPD8_1835	COG1136	(ABC) transporter
YPD8_1837	COG0577	efflux transmembrane transporter activity
YPD8_1837	COG1136	(ABC) transporter
YPD8_1840	COG0672	)-iron permease
YPD8_1842	COG2066	Belongs to the glutaminase family
YPD8_1843	COG1349	DNA-binding transcription factor activity
YPD8_1845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YPD8_1846	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YPD8_1854	COG2030	dehydratase
YPD8_1855	COG0427	acetyl-CoA hydrolase
YPD8_1857	COG2205	protein histidine kinase activity
YPD8_1857	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD8_1860	COG3188	usher protein
YPD8_1862	COG3121	Chaperone
YPD8_1863	COG0582	viral genome integration into host DNA
YPD8_1864	COG1169	isochorismate synthase
YPD8_1865	COG2814	Major facilitator Superfamily
YPD8_1866	COG1132	(ABC) transporter
YPD8_1870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPD8_1870	COG2226	methyltransferase
YPD8_1870	COG3433	isochorismatase activity
YPD8_1875	COG1021	2,3-dihydroxybenzoate-AMP ligase
YPD8_1876	COG4771	TonB-dependent receptor
YPD8_1882	COG0395	ABC-type sugar transport system, permease component
YPD8_1883	COG1175	transmembrane transport
YPD8_1885	COG0673	inositol 2-dehydrogenase activity
YPD8_1889	COG3328	transposase activity
YPD8_1890	COG3328	transposase activity
YPD8_1895	COG1943	Transposase
YPD8_1899	COG2197	response regulator
YPD8_1900	COG3136	membrane protein required for alginate biosynthesis
YPD8_1902	COG1113	amino acid transport
YPD8_1905	COG2837	iron assimilation
YPD8_1909	COG0506	proline dehydrogenase activity
YPD8_1909	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YPD8_1909	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YPD8_1912	COG0506	proline dehydrogenase activity
YPD8_1912	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YPD8_1912	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YPD8_1917	COG2515	1-aminocyclopropane-1-carboxylate deaminase
YPD8_1919	COG1191	sigma factor activity
YPD8_1925	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YPD8_1926	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
YPD8_1927	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
YPD8_1928	COG1677	Flagellar hook-basal body complex protein FliE
YPD8_1931	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
YPD8_1933	COG1157	protein secretion by the type III secretion system
YPD8_1934	COG2882	bacterial-type flagellum organization
YPD8_1937	COG1580	Controls the rotational direction of flagella during chemotaxis
YPD8_1944	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD8_1945	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_1946	COG1129	ABC transporter
YPD8_1948	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_1949	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_1949	COG3347	Dehydrogenase
YPD8_1950	COG2390	Transcriptional regulator
YPD8_1952	COG1256	bacterial-type flagellum assembly
YPD8_1956	COG4786	Flagellar basal body rod
YPD8_1958	COG1749	Flagellar hook protein flgE
YPD8_1959	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
YPD8_1960	COG1558	bacterial-type flagellum-dependent cell motility
YPD8_1961	COG1815	bacterial-type flagellum-dependent cell motility
YPD8_1963	COG2747	anti-sigma28 factor FlgM
YPD8_1964	COG3418	PFAM FlgN family protein
YPD8_1966	COG1943	Transposase
YPD8_1968	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPD8_1969	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPD8_1974	COG2372	response to copper ion
YPD8_1975	COG1528	Iron-storage protein
YPD8_1977	COG1770	oligopeptidase
YPD8_1980	COG3141	response to X-ray
YPD8_1981	COG0513	Belongs to the DEAD box helicase family
YPD8_1985	COG1760	l-serine dehydratase
YPD8_1986	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YPD8_1987	COG2368	4-hydroxyphenylacetate
YPD8_1990	COG3971	2-oxopent-4-enoate hydratase activity
YPD8_1992	COG3384	dioxygenase
YPD8_1993	COG1012	belongs to the aldehyde dehydrogenase family
YPD8_1996	COG1846	Transcriptional regulator
YPD8_1997	COG1253	flavin adenine dinucleotide binding
YPD8_1998	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD8_1998	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD8_1999	COG3715	PTS system
YPD8_2000	COG3716	PTS system mannose fructose sorbose family IID component
YPD8_2004	COG5002	protein histidine kinase activity
YPD8_2004	COG5001	Diguanylate cyclase
YPD8_2004	COG3447	MASE1 domain protein
YPD8_2005	COG2226	methyltransferase
YPD8_2008	COG1113	amino acid transport
YPD8_2009	COG2207	Transcriptional regulator
YPD8_2010	COG1132	(ABC) transporter
YPD8_2016	COG3328	transposase activity
YPD8_2018	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_2020	COG1175	transmembrane transport
YPD8_2021	COG0395	ABC-type sugar transport system, permease component
YPD8_2022	COG3842	ATPase activity
YPD8_2023	COG1653	transport
YPD8_2024	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YPD8_2025	COG1988	membrane-bound metal-dependent
YPD8_2027	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPD8_2029	COG0823	Involved in the tonB-independent uptake of proteins
YPD8_2030	COG2814	Major facilitator Superfamily
YPD8_2031	COG3121	Chaperone
YPD8_2034	COG3121	Chaperone
YPD8_2035	COG3539	Fimbrial protein
YPD8_2037	COG0793	Belongs to the peptidase S41A family
YPD8_2039	COG1956	GAF domain-containing protein
YPD8_2040	COG2995	paraquat-inducible protein a
YPD8_2041	COG2995	paraquat-inducible protein a
YPD8_2042	COG3008	intermembrane lipid transfer
YPD8_2045	COG3121	Chaperone
YPD8_2052	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YPD8_2054	COG5295	Hep Hag repeat protein
YPD8_2056	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPD8_2057	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
YPD8_2058	COG0745	RESPONSE REGULATOR receiver
YPD8_2060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YPD8_2061	COG0840	transmembrane signaling receptor activity
YPD8_2062	COG0840	transmembrane signaling receptor activity
YPD8_2066	COG2964	Protein conserved in bacteria
YPD8_2068	COG0251	oxidation-reduction process
YPD8_2069	COG2271	Major facilitator Superfamily
YPD8_2070	COG0835	chemotaxis
YPD8_2071	COG2198	Histidine kinase
YPD8_2071	COG0643	Histidine kinase
YPD8_2072	COG1360	Flagellar Motor Protein
YPD8_2076	COG1285	pathogenesis
YPD8_2077	COG0840	transmembrane signaling receptor activity
YPD8_2078	COG0840	transmembrane signaling receptor activity
YPD8_2080	COG3321	synthase
YPD8_2080	COG0604	alcohol dehydrogenase
YPD8_2080	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_2082	COG1522	sequence-specific DNA binding
YPD8_2085	COG1733	regulation of RNA biosynthetic process
YPD8_2086	COG0702	epimerase
YPD8_2087	COG0840	transmembrane signaling receptor activity
YPD8_2089	COG0538	isocitrate dehydrogenase activity
YPD8_2090	COG1187	pseudouridine synthase activity
YPD8_2094	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YPD8_2095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YPD8_2097	COG0745	RESPONSE REGULATOR receiver
YPD8_2099	COG2205	protein histidine kinase activity
YPD8_2100	COG2850	peptidyl-arginine hydroxylation
YPD8_2102	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
YPD8_2104	COG4591	ABC-type transport system involved in lipoprotein release permease component
YPD8_2106	COG4591	ABC-type transport system involved in lipoprotein release permease component
YPD8_2109	COG3134	Outer membrane lipoprotein
YPD8_2110	COG3328	transposase activity
YPD8_2113	COG1252	NADH dehydrogenase
YPD8_2115	COG1472	Belongs to the glycosyl hydrolase 3 family
YPD8_2118	COG5633	Lipoprotein
YPD8_2119	COG0537	adenosine 5'-monophosphoramidase activity
YPD8_2120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YPD8_2121	COG1943	Transposase
YPD8_2122	COG1263	PTS System
YPD8_2122	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD8_2123	COG0084	hydrolase, TatD family'
YPD8_2124	COG0470	DNA polymerase III
YPD8_2126	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YPD8_2127	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YPD8_2128	COG1943	Transposase
YPD8_2129	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD8_2130	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_2134	COG1399	metal-binding, possibly nucleic acid-binding protein
YPD8_2136	COG1943	Transposase
YPD8_2137	COG0564	pseudouridine synthase activity
YPD8_2138	COG1530	ribonuclease E activity
YPD8_2139	COG3328	transposase activity
YPD8_2141	COG1609	Transcriptional regulator
YPD8_2142	COG0280	phosphate acetyltransferase
YPD8_2142	COG0857	belongs to the CobB CobQ family
YPD8_2146	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPD8_2147	COG0490	domain, Protein
YPD8_2147	COG0471	metal ion transport
YPD8_2149	COG0436	Aminotransferase
YPD8_2150	COG0583	DNA-binding transcription factor activity
YPD8_2152	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPD8_2154	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
YPD8_2156	COG1034	ATP synthesis coupled electron transport
YPD8_2159	COG0839	Belongs to the complex I subunit 6 family
YPD8_2161	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
YPD8_2162	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPD8_2165	COG2731	YhcH YjgK YiaL family protein
YPD8_2166	COG3265	gluconokinase activity
YPD8_2167	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_2169	COG1609	Transcriptional regulator
YPD8_2170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YPD8_2173	COG0129	dihydroxy-acid dehydratase activity
YPD8_2174	COG0129	dihydroxy-acid dehydratase activity
YPD8_2176	COG1169	isochorismate synthase
YPD8_2179	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
YPD8_2182	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YPD8_2187	COG1126	abc transporter atp-binding protein
YPD8_2188	COG0765	amino acid transport
YPD8_2189	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD8_2195	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
YPD8_2199	COG1063	alcohol dehydrogenase
YPD8_2200	COG1879	ABC-type sugar transport system periplasmic component
YPD8_2202	COG1129	ABC transporter
YPD8_2203	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_2204	COG1609	Transcriptional regulator
YPD8_2205	COG0583	DNA-binding transcription factor activity
YPD8_2206	COG0473	3-isopropylmalate dehydrogenase activity
YPD8_2207	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YPD8_2208	COG4638	Rieske (2fe-2S)
YPD8_2209	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD8_2210	COG2831	hemolysin activation secretion protein
YPD8_2214	COG3210	domain, Protein
YPD8_2215	COG3210	domain, Protein
YPD8_2217	COG3842	ATPase activity
YPD8_2219	COG1609	Transcriptional regulator
YPD8_2222	COG0395	ABC-type sugar transport system, permease component
YPD8_2223	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
YPD8_2227	COG0668	transmembrane transport
YPD8_2228	COG1518	maintenance of DNA repeat elements
YPD8_2229	COG1203	CRISPR-associated helicase, Cas3
YPD8_2235	COG0667	Aldo Keto reductase
YPD8_2237	COG0477	Major facilitator Superfamily
YPD8_2238	COG0583	DNA-binding transcription factor activity
YPD8_2239	COG2771	luxR family
YPD8_2240	COG3916	Acyl-homoserine-lactone synthase
YPD8_2243	COG0628	permease
YPD8_2246	COG3328	transposase activity
YPD8_2248	COG3328	transposase activity
YPD8_2249	COG4953	penicillin-binding protein 1C
YPD8_2250	COG2373	Large extracellular alpha-helical protein
YPD8_2254	COG3962	Belongs to the TPP enzyme family
YPD8_2255	COG0673	inositol 2-dehydrogenase activity
YPD8_2256	COG0673	inositol 2-dehydrogenase activity
YPD8_2257	COG1879	ABC-type sugar transport system periplasmic component
YPD8_2258	COG1129	ABC transporter
YPD8_2259	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_2260	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_2261	COG0673	inositol 2-dehydrogenase activity
YPD8_2262	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD8_2264	COG3718	enzyme involved in inositol metabolism
YPD8_2266	COG5265	(ABC) transporter
YPD8_2269	COG1278	Cold shock
YPD8_2270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPD8_2273	COG1686	Belongs to the peptidase S11 family
YPD8_2274	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YPD8_2275	COG0772	Belongs to the SEDS family
YPD8_2276	COG0768	penicillin binding
YPD8_2278	COG0799	negative regulation of ribosome biogenesis
YPD8_2280	COG1466	dna polymerase III delta subunit
YPD8_2283	COG2888	peptidyl-tyrosine sulfation
YPD8_2284	COG1126	abc transporter atp-binding protein
YPD8_2285	COG0765	amino acid transport
YPD8_2286	COG0765	amino acid transport
YPD8_2288	COG0815	Transfers the fatty acyl group on membrane lipoproteins
YPD8_2289	COG4535	Mg2 and Co2 transporter CorC
YPD8_2291	COG1702	phosphate starvation-inducible protein PhoH
YPD8_2293	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPD8_2294	COG0367	asparagine synthase
YPD8_2295	COG0647	UMP catabolic process
YPD8_2296	COG1940	carbohydrate kinase activity
YPD8_2296	COG1846	Transcriptional regulator
YPD8_2297	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
YPD8_2299	COG1263	PTS System
YPD8_2299	COG2190	(PTS) system
YPD8_2299	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD8_2300	COG1943	Transposase
YPD8_2305	COG0735	belongs to the Fur family
YPD8_2307	COG0596	Alpha beta hydrolase
YPD8_2308	COG0582	viral genome integration into host DNA
YPD8_2312	COG2113	Glycine betaine
YPD8_2313	COG4176	ABC-type proline glycine betaine transport system permease component
YPD8_2314	COG4175	Glycine betaine
YPD8_2315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YPD8_2322	COG0747	negative chemotaxis
YPD8_2325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPD8_2326	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YPD8_2327	COG1124	(ABC) transporter
YPD8_2333	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
YPD8_2335	COG4413	Urea transporter
YPD8_2336	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
YPD8_2338	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YPD8_2339	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPD8_2340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPD8_2341	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YPD8_2342	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YPD8_2343	COG1447	Phosphotransferase system cellobiose-specific component IIA
YPD8_2344	COG1917	Cupin 2, conserved barrel domain protein
YPD8_2344	COG2169	Transcriptional regulator
YPD8_2346	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
YPD8_2347	COG0033	Phosphoglucomutase
YPD8_2349	COG0745	RESPONSE REGULATOR receiver
YPD8_2350	COG2205	protein histidine kinase activity
YPD8_2354	COG3272	Protein of unknown function (DUF1722)
YPD8_2356	COG5212	phosphodiesterase
YPD8_2357	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
YPD8_2358	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
YPD8_2359	COG1984	allophanate hydrolase subunit 2
YPD8_2368	COG0513	Belongs to the DEAD box helicase family
YPD8_2370	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
YPD8_2372	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
YPD8_2373	COG3026	antisigma factor binding
YPD8_2374	COG3086	response to oxidative stress
YPD8_2377	COG0681	Belongs to the peptidase S26 family
YPD8_2383	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
YPD8_2385	COG1943	Transposase
YPD8_2386	COG1737	Transcriptional regulator
YPD8_2388	COG0560	Phosphoserine phosphatase
YPD8_2389	COG0590	tRNA wobble adenosine to inosine editing
YPD8_2395	COG1943	Transposase
YPD8_2396	COG2205	protein histidine kinase activity
YPD8_2397	COG3170	Tfp pilus assembly protein FimV
YPD8_2398	COG2204	response regulator
YPD8_2399	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPD8_2399	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YPD8_2400	COG0347	Belongs to the P(II) protein family
YPD8_2401	COG2188	Transcriptional regulator
YPD8_2402	COG2188	Transcriptional regulator
YPD8_2403	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD8_2403	COG1017	nitric oxide dioxygenase activity
YPD8_2406	COG2814	Major facilitator Superfamily
YPD8_2407	COG3711	transcriptional antiterminator
YPD8_2408	COG3683	transport system, periplasmic component
YPD8_2409	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
YPD8_2410	COG1943	Transposase
YPD8_2411	COG0483	inositol monophosphate 1-phosphatase activity
YPD8_2414	COG1104	cysteine desulfurase activity
YPD8_2415	COG0822	iron-sulfur transferase activity
YPD8_2417	COG0443	Heat shock 70 kDa protein
YPD8_2418	COG0633	Ferredoxin
YPD8_2422	COG3468	outer membrane autotransporter barrel domain protein
YPD8_2423	COG3468	outer membrane autotransporter barrel domain protein
YPD8_2431	COG2976	Protein conserved in bacteria
YPD8_2432	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPD8_2436	COG0516	GMP reductase activity
YPD8_2436	COG0517	IMP dehydrogenase activity
YPD8_2438	COG1943	Transposase
YPD8_2441	COG3328	transposase activity
YPD8_2443	COG0351	phosphomethylpyrimidine kinase
YPD8_2448	COG3422	double-strand break repair
YPD8_2449	COG0745	RESPONSE REGULATOR receiver
YPD8_2450	COG2205	protein histidine kinase activity
YPD8_2455	COG3842	ATPase activity
YPD8_2457	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YPD8_2459	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPD8_2460	COG1177	transmembrane transport
YPD8_2461	COG0443	Heat shock 70 kDa protein
YPD8_2462	COG2239	Acts as a magnesium transporter
YPD8_2463	COG0248	Ppx GppA phosphatase
YPD8_2464	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
YPD8_2466	COG0581	inorganic phosphate transmembrane transporter activity
YPD8_2470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPD8_2471	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
YPD8_2474	COG1943	Transposase
YPD8_2477	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
YPD8_2478	COG4589	Belongs to the CDS family
YPD8_2480	COG2267	carboxylic ester hydrolase activity
YPD8_2481	COG0671	phosphoesterase, PA-phosphatase related
YPD8_2481	COG2453	phosphatase
YPD8_2487	COG0667	Aldo Keto reductase
YPD8_2488	COG0656	L-ascorbic acid biosynthetic process
YPD8_2493	COG3328	transposase activity
YPD8_2494	COG2850	peptidyl-arginine hydroxylation
YPD8_2501	COG4953	penicillin-binding protein 1C
YPD8_2502	COG3328	transposase activity
YPD8_2503	COG3037	sugar-specific permease SgaT UlaA
YPD8_2504	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
YPD8_2505	COG0622	Phosphoesterase
YPD8_2507	COG1090	epimerase
YPD8_2508	COG4598	ABC transporter
YPD8_2509	COG4160	amino acid transport
YPD8_2510	COG4215	(ABC) transporter
YPD8_2511	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD8_2512	COG0163	prenyltransferase activity
YPD8_2513	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
YPD8_2514	COG1286	toxin biosynthetic process
YPD8_2515	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
YPD8_2516	COG0285	dihydrofolate synthase activity
YPD8_2518	COG0586	Pfam SNARE associated Golgi protein
YPD8_2520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YPD8_2523	COG0697	spore germination
YPD8_2526	COG1794	racemase activity, acting on amino acids and derivatives
YPD8_2527	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD8_2530	COG3101	peptidyl-lysine hydroxylation
YPD8_2531	COG0730	response to heat
YPD8_2534	COG2890	protein-(glutamine-N5) methyltransferase activity
YPD8_2536	COG2062	phosphohistidine phosphatase, SixA
YPD8_2541	COG3088	subunit of a heme lyase
YPD8_2541	COG4235	cytochrome complex assembly
YPD8_2542	COG4235	cytochrome complex assembly
YPD8_2542	COG3088	subunit of a heme lyase
YPD8_2543	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YPD8_2544	COG1138	Cytochrome C-type biogenesis protein
YPD8_2546	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPD8_2547	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPD8_2548	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPD8_2551	COG1704	LemA family
YPD8_2553	COG2824	Alkylphosphonate utilization operon protein PhnA
YPD8_2558	COG3501	Rhs element vgr protein
YPD8_2570	COG3188	usher protein
YPD8_2571	COG3328	transposase activity
YPD8_2572	COG3188	usher protein
YPD8_2573	COG3121	Chaperone
YPD8_2585	COG2951	lytic endotransglycosylase activity
YPD8_2591	COG0243	molybdopterin cofactor binding
YPD8_2592	COG0437	4 iron, 4 sulfur cluster binding
YPD8_2593	COG3302	dmso reductase anchor subunit
YPD8_2594	COG3381	protein complex oligomerization
YPD8_2600	COG3038	cytochrome b561
YPD8_2601	COG0436	Aminotransferase
YPD8_2606	COG0667	Aldo Keto reductase
YPD8_2608	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YPD8_2610	COG1943	Transposase
YPD8_2615	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
YPD8_2616	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YPD8_2618	COG2190	(PTS) system
YPD8_2619	COG1943	Transposase
YPD8_2620	COG2205	protein histidine kinase activity
YPD8_2621	COG0745	RESPONSE REGULATOR receiver
YPD8_2622	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD8_2625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YPD8_2626	COG0006	proline dipeptidase activity
YPD8_2627	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
YPD8_2629	COG5002	protein histidine kinase activity
YPD8_2629	COG3850	Histidine kinase
YPD8_2630	COG0745	RESPONSE REGULATOR receiver
YPD8_2633	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
YPD8_2634	COG4208	sulfate ABC transporter
YPD8_2635	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
YPD8_2636	COG4150	thiosulfate binding
YPD8_2638	COG1737	Transcriptional regulator
YPD8_2639	COG2731	YhcH YjgK YiaL family protein
YPD8_2641	COG4886	Leucine-rich repeat (LRR) protein
YPD8_2644	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YPD8_2645	COG2837	iron assimilation
YPD8_2647	COG3111	PFAM Bacterial OB fold (BOF) protein
YPD8_2655	COG3005	denitrification pathway
YPD8_2656	COG3043	anaerobic respiration
YPD8_2658	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPD8_2659	COG2197	response regulator
YPD8_2660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPD8_2662	COG1988	membrane-bound metal-dependent
YPD8_2663	COG0641	radical SAM
YPD8_2664	COG3119	arylsulfatase activity
YPD8_2665	COG3842	ATPase activity
YPD8_2666	COG1175	transmembrane transport
YPD8_2667	COG1840	ABC-type Fe3 transport system, periplasmic component
YPD8_2669	COG1393	Belongs to the ArsC family
YPD8_2671	COG1876	peptidase activity
YPD8_2674	COG2321	neutral zinc metallopeptidase
YPD8_2676	COG1943	Transposase
YPD8_2677	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
YPD8_2679	COG2716	regulation of RNA biosynthetic process
YPD8_2680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YPD8_2682	COG0628	permease
YPD8_2683	COG4783	chaperone-mediated protein folding
YPD8_2684	COG1393	Belongs to the ArsC family
YPD8_2686	COG1943	Transposase
YPD8_2688	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YPD8_2690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
YPD8_2691	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
YPD8_2692	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
YPD8_2693	COG4181	ATPase activity
YPD8_2694	COG2755	lipolytic protein G-D-S-L family
YPD8_2695	COG0300	oxidoreductase activity
YPD8_2696	COG3118	belongs to the thioredoxin family
YPD8_2697	COG0330	HflC and HflK could
YPD8_2698	COG1585	Membrane protein implicated in regulation of membrane protease activity
YPD8_2699	COG0789	Transcriptional regulator
YPD8_2700	COG2217	Heavy metal translocating P-type atpase
YPD8_2701	COG3735	TraB family
YPD8_2702	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YPD8_2703	COG0737	Belongs to the 5'-nucleotidase family
YPD8_2704	COG0737	Belongs to the 5'-nucleotidase family
YPD8_2705	COG2223	nitrite transmembrane transporter activity
YPD8_2706	COG4651	solute:proton antiporter activity
YPD8_2706	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YPD8_2707	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD8_2708	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YPD8_2712	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD8_2713	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
YPD8_2714	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
YPD8_2720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD8_2724	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD8_2724	COG0543	2 iron, 2 sulfur cluster binding
YPD8_2730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
YPD8_2733	COG1196	nuclear chromosome segregation
YPD8_2733	COG3264	Mechanosensitive ion channel
YPD8_2734	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
YPD8_2735	COG1309	transcriptional regulator
YPD8_2736	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD8_2737	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPD8_2740	COG3695	enzyme binding
YPD8_2741	COG3126	Type III secretion system lipoprotein chaperone (YscW)
YPD8_2742	COG1946	Acyl-CoA thioesterase
YPD8_2743	COG0004	ammonium transporteR
YPD8_2744	COG0347	Belongs to the P(II) protein family
YPD8_2745	COG1132	(ABC) transporter
YPD8_2746	COG1132	(ABC) transporter
YPD8_2747	COG1522	sequence-specific DNA binding
YPD8_2750	COG4533	DNA binding
YPD8_2752	COG0824	Thioesterase
YPD8_2753	COG1555	photosystem II stabilization
YPD8_2754	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YPD8_2755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YPD8_2759	COG0271	Belongs to the BolA IbaG family
YPD8_2760	COG3056	Lipoprotein
YPD8_2761	COG2223	nitrite transmembrane transporter activity
YPD8_2763	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YPD8_2764	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YPD8_2765	COG1845	cytochrome c oxidase, subunit III
YPD8_2766	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
YPD8_2768	COG2814	Major facilitator Superfamily
YPD8_2770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
YPD8_2771	COG0693	protein deglycase activity
YPD8_2774	COG0142	geranyltranstransferase activity
YPD8_2776	COG1943	Transposase
YPD8_2777	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
YPD8_2778	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
YPD8_2781	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YPD8_2781	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YPD8_2785	COG1943	Transposase
YPD8_2786	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YPD8_2787	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YPD8_2788	COG1862	Preprotein translocase
YPD8_2790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
YPD8_2792	COG0450	alkyl hydroperoxide reductase
YPD8_2795	COG0366	Alpha amylase catalytic
YPD8_2798	COG0366	Alpha amylase catalytic
YPD8_2800	COG1114	Component of the transport system for branched-chain amino acids
YPD8_2802	COG5002	protein histidine kinase activity
YPD8_2803	COG0745	RESPONSE REGULATOR receiver
YPD8_2804	COG0420	3'-5' exonuclease activity
YPD8_2805	COG0419	ATPase involved in DNA repair
YPD8_2806	COG1940	carbohydrate kinase activity
YPD8_2810	COG2226	methyltransferase
YPD8_2819	COG2195	Cleaves the N-terminal amino acid of tripeptides
YPD8_2822	COG1477	protein flavinylation
YPD8_2826	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YPD8_2827	COG1805	sodium ion transport
YPD8_2828	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YPD8_2829	COG3034	peptidoglycan biosynthetic process
YPD8_2830	COG0121	glutamine amidotransferase
YPD8_2832	COG1960	acyl-CoA dehydrogenase activity
YPD8_2834	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
YPD8_2838	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YPD8_2841	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YPD8_2849	COG2814	Major facilitator Superfamily
YPD8_2850	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
YPD8_2852	COG1846	Transcriptional regulator
YPD8_2853	COG1566	PFAM secretion protein HlyD family protein
YPD8_2854	COG2814	Major facilitator Superfamily
YPD8_2855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPD8_2856	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPD8_2857	COG3118	belongs to the thioredoxin family
YPD8_2859	COG0045	succinate-CoA ligase (ADP-forming) activity
YPD8_2859	COG1042	CoA-binding domain protein
YPD8_2859	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPD8_2860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YPD8_2861	COG5544	Lipoprotein
YPD8_2863	COG0542	response to heat
YPD8_2865	COG0564	pseudouridine synthase activity
YPD8_2866	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPD8_2867	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
YPD8_2868	COG1943	Transposase
YPD8_2869	COG1605	Chorismate mutase
YPD8_2869	COG0077	Prephenate dehydratase
YPD8_2872	COG0077	Prephenate dehydratase
YPD8_2872	COG1605	Chorismate mutase
YPD8_2873	COG0287	Prephenate dehydrogenase
YPD8_2873	COG1605	Chorismate mutase
YPD8_2874	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YPD8_2875	COG3279	Response regulator of the LytR AlgR family
YPD8_2876	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPD8_2877	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPD8_2878	COG3137	Salt-induced outer membrane protein
YPD8_2879	COG1943	Transposase
YPD8_2883	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YPD8_2884	COG4137	Cytochrome C assembly protein
YPD8_2885	COG4536	flavin adenine dinucleotide binding
YPD8_2886	COG1943	Transposase
YPD8_2888	COG2918	glutathione biosynthetic process
YPD8_2889	COG1238	metal cluster binding
YPD8_2890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPD8_2898	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YPD8_2899	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YPD8_2900	COG3958	Transketolase
YPD8_2901	COG3959	Transketolase, thiamine diphosphate binding domain
YPD8_2902	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_2903	COG1129	ABC transporter
YPD8_2908	COG3783	Cytochrome b(562)
YPD8_2909	COG3381	protein complex oligomerization
YPD8_2910	COG3302	dmso reductase anchor subunit
YPD8_2911	COG0437	4 iron, 4 sulfur cluster binding
YPD8_2912	COG0243	molybdopterin cofactor binding
YPD8_2913	COG0235	Class ii aldolase
YPD8_2914	COG1349	DNA-binding transcription factor activity
YPD8_2916	COG1943	Transposase
YPD8_2917	COG1129	ABC transporter
YPD8_2918	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_2919	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_2920	COG3623	hexulose-6-phosphate isomerase
YPD8_2921	COG1070	Carbohydrate kinase
YPD8_2922	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
YPD8_2922	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
YPD8_2923	COG0024	Methionine aminopeptidase
YPD8_2926	COG4771	TonB-dependent receptor
YPD8_2927	COG1858	cytochrome C peroxidase
YPD8_2928	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD8_2930	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YPD8_2933	COG2376	Dihydroxyacetone kinase
YPD8_2934	COG1028	Short-chain dehydrogenase reductase Sdr
YPD8_2935	COG1063	alcohol dehydrogenase
YPD8_2936	COG0698	ribose 5-phosphate isomerase
YPD8_2937	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
YPD8_2938	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YPD8_2944	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
YPD8_2947	COG0529	Catalyzes the synthesis of activated sulfate
YPD8_2955	COG0720	synthase
YPD8_2956	COG0602	queuosine metabolic process
YPD8_2960	COG3956	TIGRFAM MazG family protein
YPD8_2961	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YPD8_2962	COG2205	protein histidine kinase activity
YPD8_2962	COG3437	response regulator, receiver
YPD8_2962	COG4999	Histidine kinase
YPD8_2962	COG3850	Histidine kinase
YPD8_2963	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPD8_2965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YPD8_2967	COG2860	membrane
YPD8_2971	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD8_2972	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YPD8_2973	COG1120	ATPase activity
YPD8_2974	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YPD8_2976	COG1643	Atp-dependent helicase
YPD8_2977	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
YPD8_2979	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
YPD8_2980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YPD8_2981	COG0617	tRNA 3'-terminal CCA addition
YPD8_2982	COG0617	tRNA 3'-terminal CCA addition
YPD8_2983	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YPD8_2987	COG0726	polysaccharide deacetylase
YPD8_2988	COG0842	Transport permease protein
YPD8_2989	COG1131	(ABC) transporter
YPD8_2990	COG0288	reversible hydration of carbon dioxide
YPD8_2991	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
YPD8_2992	COG2132	Multicopper oxidase
YPD8_2993	COG2132	Multicopper oxidase
YPD8_2997	COG0697	spore germination
YPD8_2999	COG1049	propionate catabolic process, 2-methylcitrate cycle
YPD8_3000	COG1943	Transposase
YPD8_3001	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPD8_3002	COG0508	dehydrogenase complex catalyzes the overall conversion of
YPD8_3003	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
YPD8_3004	COG2186	Transcriptional regulator
YPD8_3005	COG1113	amino acid transport
YPD8_3006	COG3725	Membrane protein required for beta-lactamase induction
YPD8_3007	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPD8_3009	COG4969	Belongs to the N-Me-Phe pilin family
YPD8_3010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YPD8_3011	COG1459	type II secretion system
YPD8_3013	COG0237	dephospho-CoA kinase activity
YPD8_3020	COG0582	viral genome integration into host DNA
YPD8_3021	COG0795	lipopolysaccharide-transporting ATPase activity
YPD8_3022	COG0795	lipopolysaccharide-transporting ATPase activity
YPD8_3024	COG2927	DNA polymerase III (CHI subunit)
YPD8_3025	COG0525	valine-tRNA ligase activity
YPD8_3027	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
YPD8_3028	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YPD8_3029	COG2731	YhcH YjgK YiaL family protein
YPD8_3032	COG0601	transmembrane transport
YPD8_3033	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPD8_3034	COG0444	Belongs to the ABC transporter superfamily
YPD8_3035	COG4608	Belongs to the ABC transporter superfamily
YPD8_3038	COG2188	Transcriptional regulator
YPD8_3039	COG3624	Phosphonate C-P lyase system protein PhnG
YPD8_3040	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
YPD8_3041	COG3626	phosphonate metabolism
YPD8_3042	COG3627	carbon phosphorus lyase activity
YPD8_3043	COG4107	phosphonate C-P lyase system protein PhnK
YPD8_3044	COG4778	phosphonate C-P lyase system protein PhnL
YPD8_3045	COG3454	Phosphonate metabolism
YPD8_3046	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
YPD8_3047	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YPD8_3048	COG0702	epimerase
YPD8_3051	COG3842	ATPase activity
YPD8_3052	COG0395	ABC-type sugar transport system, permease component
YPD8_3054	COG1653	transport
YPD8_3057	COG3153	acetyltransferase
YPD8_3062	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPD8_3064	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YPD8_3066	COG0513	Belongs to the DEAD box helicase family
YPD8_3069	COG2801	Transposase and inactivated derivatives
YPD8_3074	COG0195	Participates in both transcription termination and antitermination
YPD8_3077	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YPD8_3078	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YPD8_3079	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YPD8_3081	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPD8_3082	COG2027	D-alanyl-D-alanine carboxypeptidase
YPD8_3083	COG0745	RESPONSE REGULATOR receiver
YPD8_3084	COG0642	Histidine kinase
YPD8_3086	COG0697	spore germination
YPD8_3088	COG0142	geranyltranstransferase activity
YPD8_3092	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YPD8_3094	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YPD8_3095	COG2105	PFAM AIG2 family protein
YPD8_3096	COG2911	Protein conserved in bacteria
YPD8_3097	COG0729	surface antigen
YPD8_3101	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
YPD8_3103	COG0737	Belongs to the 5'-nucleotidase family
YPD8_3105	COG0545	Peptidyl-prolyl cis-trans isomerase
YPD8_3106	COG3061	Opacity-associated protein A
YPD8_3108	COG1943	Transposase
YPD8_3110	COG0360	Binds together with S18 to 16S ribosomal RNA
YPD8_3111	COG1073	alpha beta
YPD8_3114	COG0435	Glutathione S-transferase
YPD8_3115	COG0583	DNA-binding transcription factor activity
YPD8_3116	COG1741	Belongs to the pirin family
YPD8_3117	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
YPD8_3121	COG2823	Periplasmic or secreted lipoprotein
YPD8_3123	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
YPD8_3124	COG5002	protein histidine kinase activity
YPD8_3124	COG2198	Histidine kinase
YPD8_3124	COG0784	Response regulator, receiver
YPD8_3125	COG1242	4 iron, 4 sulfur cluster binding
YPD8_3126	COG0067	glutamate synthase
YPD8_3126	COG0069	glutamate synthase activity
YPD8_3126	COG0070	glutamate synthase
YPD8_3127	COG0493	'glutamate synthase
YPD8_3129	COG2969	positive regulation of protein catabolic process
YPD8_3130	COG0625	glutathione transferase activity
YPD8_3133	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YPD8_3134	COG3105	Protein conserved in bacteria
YPD8_3135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPD8_3136	COG1943	Transposase
YPD8_3137	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPD8_3139	COG3113	response to antibiotic
YPD8_3140	COG2854	intermembrane phospholipid transfer
YPD8_3141	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YPD8_3142	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YPD8_3143	COG1127	ABC transporter
YPD8_3144	COG0530	calcium, potassium:sodium antiporter activity
YPD8_3145	COG0517	IMP dehydrogenase activity
YPD8_3145	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
YPD8_3146	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
YPD8_3147	COG3117	lipopolysaccharide transmembrane transporter activity
YPD8_3148	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
YPD8_3149	COG1137	ATPase activity
YPD8_3150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
YPD8_3151	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD8_3157	COG1609	Transcriptional regulator
YPD8_3158	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD8_3158	COG1263	PTS System
YPD8_3159	COG0366	Alpha amylase catalytic
YPD8_3160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPD8_3161	COG3783	Cytochrome b(562)
YPD8_3163	COG0312	modulator of DNA gyrase
YPD8_3167	COG1012	belongs to the aldehyde dehydrogenase family
YPD8_3170	COG0583	DNA-binding transcription factor activity
YPD8_3180	COG0312	modulator of DNA gyrase
YPD8_3181	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPD8_3182	COG3164	Protein of unknown function
YPD8_3183	COG3164	Protein of unknown function
YPD8_3184	COG1530	ribonuclease E activity
YPD8_3186	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
YPD8_3187	COG1792	Involved in formation and maintenance of cell shape
YPD8_3188	COG1077	Cell shape determining protein MreB Mrl
YPD8_3189	COG2199	diguanylate cyclase activity
YPD8_3189	COG2200	EAL domain
YPD8_3190	COG0604	alcohol dehydrogenase
YPD8_3191	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
YPD8_3194	COG0511	ligase activity, forming carbon-carbon bonds
YPD8_3195	COG0439	Biotin carboxylase
YPD8_3196	COG4145	pantothenate transmembrane transporter activity
YPD8_3198	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPD8_3202	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPD8_3204	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YPD8_3205	COG3133	Outer membrane lipoprotein
YPD8_3206	COG1943	Transposase
YPD8_3209	COG0625	glutathione transferase activity
YPD8_3211	COG1069	ribulokinase activity
YPD8_3213	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_3214	COG1129	ABC transporter
YPD8_3216	COG1560	Kdo2-lipid A biosynthetic process
YPD8_3218	COG0025	NhaP-type Na H and K H
YPD8_3219	COG2252	PERMEase
YPD8_3221	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPD8_3223	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YPD8_3224	COG0431	NADPH-dependent FMN reductase
YPD8_3226	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD8_3227	COG1869	D-ribose catabolic process
YPD8_3228	COG2207	Transcriptional regulator
YPD8_3228	COG1917	Cupin 2, conserved barrel domain protein
YPD8_3229	COG0673	inositol 2-dehydrogenase activity
YPD8_3232	COG3209	COG3209 Rhs family protein
YPD8_3234	COG3501	Rhs element vgr protein
YPD8_3237	COG3209	COG3209 Rhs family protein
YPD8_3240	COG3501	Rhs element vgr protein
YPD8_3256	COG2801	Transposase and inactivated derivatives
YPD8_3265	COG1175	transmembrane transport
YPD8_3266	COG3833	ABC-type maltose transport systems, permease component
YPD8_3270	COG0527	aspartate kinase activity
YPD8_3275	COG1414	Transcriptional regulator
YPD8_3276	COG1414	Transcriptional regulator
YPD8_3278	COG2224	Isocitrate lyase
YPD8_3279	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
YPD8_3283	COG0151	Belongs to the GarS family
YPD8_3285	COG3068	Protein conserved in bacteria
YPD8_3286	COG1515	deoxyribonuclease V activity
YPD8_3291	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
YPD8_3293	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YPD8_3296	COG1943	Transposase
YPD8_3303	COG0250	Participates in transcription elongation, termination and antitermination
YPD8_3304	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
YPD8_3311	COG0812	UDP-N-acetylmuramate dehydrogenase activity
YPD8_3312	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YPD8_3313	COG1739	Uncharacterized protein family UPF0029
YPD8_3314	COG1943	Transposase
YPD8_3326	COG0805	protein transport
YPD8_3331	COG1322	Protein conserved in bacteria
YPD8_3332	COG0586	Pfam SNARE associated Golgi protein
YPD8_3333	COG1966	Carbon starvation protein
YPD8_3335	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
YPD8_3336	COG0412	Dienelactone hydrolase
YPD8_3338	COG0583	DNA-binding transcription factor activity
YPD8_3339	COG0679	Auxin Efflux Carrier
YPD8_3340	COG0584	glycerophosphoryl diester phosphodiesterase
YPD8_3352	COG0410	ABC transporter
YPD8_3353	COG0411	ABC transporter
YPD8_3354	COG4177	L-phenylalanine transmembrane transporter activity
YPD8_3355	COG0559	Belongs to the binding-protein-dependent transport system permease family
YPD8_3356	COG0683	leucine binding
YPD8_3358	COG1943	Transposase
YPD8_3360	COG2177	Part of the ABC transporter FtsEX involved in
YPD8_3361	COG2884	Cell division ATP-binding protein ftsE
YPD8_3362	COG0552	protein localization to endoplasmic reticulum
YPD8_3362	COG0552	protein localization to endoplasmic reticulum
YPD8_3363	COG0742	ribosomal rna small subunit methyltransferase
YPD8_3366	COG3714	YhhN family
YPD8_3369	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
YPD8_3371	COG0247	lactate metabolic process
YPD8_3373	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YPD8_3374	COG0584	glycerophosphoryl diester phosphodiesterase
YPD8_3376	COG0561	phosphatase activity
YPD8_3377	COG2267	carboxylic ester hydrolase activity
YPD8_3378	COG1280	lysine exporter protein (LysE YggA)
YPD8_3379	COG1280	lysine exporter protein (LysE YggA)
YPD8_3380	COG0514	ATP-dependent DNA helicase (RecQ)
YPD8_3381	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
YPD8_3382	COG2050	protein possibly involved in aromatic compounds catabolism
YPD8_3384	COG0598	Magnesium transport protein CorA
YPD8_3385	COG5564	TIM-barrel signal transduction protein
YPD8_3386	COG5441	Belongs to the UPF0261 family
YPD8_3388	COG0210	DNA helicase
YPD8_3389	COG1011	Hydrolase
YPD8_3390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
YPD8_3391	COG3159	Protein conserved in bacteria
YPD8_3394	COG3072	Adenylate cyclase
YPD8_3396	COG1587	Uroporphyrinogen-III synthase
YPD8_3397	COG2959	enzyme of heme biosynthesis
YPD8_3398	COG3071	HemY protein
YPD8_3399	COG1943	Transposase
YPD8_3400	COG1113	amino acid transport
YPD8_3404	COG2244	polysaccharide biosynthetic process
YPD8_3405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YPD8_3406	COG0456	acetyltransferase
YPD8_3407	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
YPD8_3408	COG1088	dTDP-glucose 4,6-dehydratase activity
YPD8_3409	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
YPD8_3410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
YPD8_3411	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YPD8_3412	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YPD8_3413	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
YPD8_3414	COG3118	belongs to the thioredoxin family
YPD8_3420	COG3328	transposase activity
YPD8_3422	COG3121	Chaperone
YPD8_3423	COG3188	usher protein
YPD8_3426	COG3121	Chaperone
YPD8_3429	COG0583	DNA-binding transcription factor activity
YPD8_3436	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YPD8_3439	COG3085	chromosome segregation
YPD8_3441	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_3442	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_3443	COG1129	ABC transporter
YPD8_3444	COG1879	ABC-type sugar transport system periplasmic component
YPD8_3452	COG0678	peroxiredoxin activity
YPD8_3452	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YPD8_3453	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPD8_3458	COG1629	transport
YPD8_3461	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
YPD8_3465	COG2801	Transposase and inactivated derivatives
YPD8_3467	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YPD8_3468	COG0058	SHG alpha-glucan phosphorylase activity
YPD8_3470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
YPD8_3474	COG3275	phosphorelay sensor kinase activity
YPD8_3476	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YPD8_3477	COG2095	MarC family integral membrane protein
YPD8_3479	COG3265	gluconokinase activity
YPD8_3480	COG2610	gluconate transmembrane transporter activity
YPD8_3481	COG1609	Transcriptional regulator
YPD8_3482	COG1741	Belongs to the pirin family
YPD8_3483	COG0745	RESPONSE REGULATOR receiver
YPD8_3485	COG0191	fructose-bisphosphate aldolase activity
YPD8_3487	COG1879	ABC-type sugar transport system periplasmic component
YPD8_3488	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD8_3491	COG2081	HI0933 family
YPD8_3492	COG0306	phosphate transporter
YPD8_3493	COG1943	Transposase
YPD8_3495	COG0589	response to stress
YPD8_3499	COG0339	signal peptide processing
YPD8_3500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
YPD8_3501	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPD8_3502	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPD8_3503	COG3835	regulator
YPD8_3504	COG2610	gluconate transmembrane transporter activity
YPD8_3505	COG1929	Belongs to the glycerate kinase type-1 family
YPD8_3511	COG1295	ribonuclease BN
YPD8_3512	COG1295	ribonuclease BN
YPD8_3513	COG2134	cdp-diacylglycerol pyrophosphatase
YPD8_3514	COG2982	Protein involved in outer membrane biogenesis
YPD8_3515	COG2200	EAL domain
YPD8_3516	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD8_3517	COG0612	Peptidase, M16
YPD8_3521	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YPD8_3522	COG2199	diguanylate cyclase activity
YPD8_3522	COG2200	EAL domain
YPD8_3523	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
YPD8_3524	COG4608	Belongs to the ABC transporter superfamily
YPD8_3525	COG0444	Belongs to the ABC transporter superfamily
YPD8_3526	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPD8_3527	COG0601	transmembrane transport
YPD8_3528	COG0747	negative chemotaxis
YPD8_3529	COG2831	hemolysin activation secretion protein
YPD8_3531	COG2271	Major facilitator Superfamily
YPD8_3535	COG3851	Histidine kinase
YPD8_3536	COG2197	response regulator
YPD8_3537	COG2194	sulfuric ester hydrolase activity
YPD8_3540	COG2986	histidine ammonia-lyase
YPD8_3543	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YPD8_3546	COG4607	ABC-type enterochelin transport system periplasmic component
YPD8_3548	COG4605	iron ion homeostasis
YPD8_3549	COG4604	ABC transporter, ATP-binding protein
YPD8_3553	COG0582	viral genome integration into host DNA
YPD8_3554	COG2207	Transcriptional regulator
YPD8_3554	COG1609	Transcriptional regulator
YPD8_3555	COG4214	carbohydrate transport
YPD8_3558	COG4213	ABC transporter substrate-binding protein
YPD8_3560	COG1070	Carbohydrate kinase
YPD8_3562	COG3121	Chaperone
YPD8_3563	COG3188	usher protein
YPD8_3564	COG3188	usher protein
YPD8_3566	COG3274	enterobacterial common antigen metabolic process
YPD8_3568	COG2801	Transposase and inactivated derivatives
YPD8_3573	COG3276	selenocysteine insertion sequence binding
YPD8_3576	COG2864	formate dehydrogenase
YPD8_3577	COG0437	4 iron, 4 sulfur cluster binding
YPD8_3578	COG3383	formate dehydrogenase (NAD+) activity
YPD8_3578	COG0243	molybdopterin cofactor binding
YPD8_3579	COG0243	molybdopterin cofactor binding
YPD8_3579	COG3383	formate dehydrogenase (NAD+) activity
YPD8_3581	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YPD8_3586	COG3722	fumarate hydratase activity
YPD8_3588	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD8_3588	COG2213	PTS system mannitol-specific
YPD8_3592	COG2818	Glycosylase
YPD8_3594	COG2885	chlorophyll binding
YPD8_3597	COG0366	Alpha amylase catalytic
YPD8_3599	COG3977	Valine--pyruvate aminotransferase
YPD8_3604	COG5645	(Lipo)protein
YPD8_3605	COG0823	Involved in the tonB-independent uptake of proteins
YPD8_3606	COG0823	Involved in the tonB-independent uptake of proteins
YPD8_3607	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YPD8_3608	COG2423	ornithine cyclodeaminase activity
YPD8_3610	COG2801	Transposase and inactivated derivatives
YPD8_3611	COG0561	phosphatase activity
YPD8_3612	COG0187	DNA topoisomerase II activity
YPD8_3613	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YPD8_3614	COG0592	DNA-directed DNA polymerase activity
YPD8_3616	COG0706	membrane insertase activity
YPD8_3620	COG2252	PERMEase
YPD8_3621	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPD8_3622	COG0765	amino acid transport
YPD8_3623	COG0765	amino acid transport
YPD8_3624	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD8_3626	COG0704	Plays a role in the regulation of phosphate uptake
YPD8_3628	COG0581	inorganic phosphate transmembrane transporter activity
YPD8_3629	COG0573	inorganic phosphate transmembrane transporter activity
YPD8_3630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YPD8_3631	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YPD8_3640	COG3312	ion transport
YPD8_pCD0001	COG2801	Transposase and inactivated derivatives
YPD8_pCD0003	COG5599	Phosphatase
YPD8_pCD0005	COG1475	DNA binding
YPD8_pCD0006	COG1192	Involved in chromosome partitioning
YPD8_pCD0007	COG2801	Transposase and inactivated derivatives
YPD8_pCD0011	COG3177	Filamentation induced by cAMP protein fic
YPD8_pCD0012	COG3328	transposase activity
YPD8_pCD0013	COG3177	Filamentation induced by cAMP protein fic
YPD8_pCD0017	COG4886	Leucine-rich repeat (LRR) protein
YPD8_pCD0021	COG0457	Tetratricopeptide repeat
YPD8_pCD0024	COG4789	Type iii secretion
YPD8_pCD0032	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
YPD8_pCD0033	COG4790	Type iii secretion
YPD8_pCD0034	COG4791	protein targeting
YPD8_pCD0035	COG4792	protein secretion
YPD8_pCD0037	COG2207	Transcriptional regulator
YPD8_pCD0045	COG4669	(LipO)protein
YPD8_pCD0047	COG1317	bacterial-type flagellum organization
YPD8_pCD0048	COG5599	Phosphatase
YPD8_pCD0049	COG2801	Transposase and inactivated derivatives
YPD8_pCD0051	COG2801	Transposase and inactivated derivatives
YPD8_pCD0053	COG0515	serine threonine protein kinase
YPD8_pCD0060	COG2801	Transposase and inactivated derivatives
YPD8_pCD0065	COG2801	Transposase and inactivated derivatives
YPD8_pMT0003	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
YPD8_pMT0004	COG5301	cellulose 1,4-beta-cellobiosidase activity
YPD8_pMT0004	COG5301	cellulose 1,4-beta-cellobiosidase activity
YPD8_pMT0011	COG3941	tape measure
YPD8_pMT0028	COG1475	DNA binding
YPD8_pMT0029	COG1475	DNA binding
YPD8_pMT0030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YPD8_pMT0034	COG1943	Transposase
YPD8_pMT0039	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YPD8_pMT0046	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
YPD8_pMT0047	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPD8_pMT0063	COG3328	transposase activity
YPD8_pMT0066	COG3344	reverse transcriptase
YPD8_pMT0068	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YPD8_pMT0080	COG1475	DNA binding
YPD8_pPCP0009	COG4683	PFAM Phage derived protein Gp49-like (DUF891)