locus-tag	class	description
CH46_10	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH46_1006	COG2801	Transposase and inactivated derivatives
CH46_1008	COG3274	enterobacterial common antigen metabolic process
CH46_1010	COG3188	usher protein
CH46_1011	COG3188	usher protein
CH46_1012	COG3121	Chaperone
CH46_1014	COG1070	Carbohydrate kinase
CH46_1016	COG4213	ABC transporter substrate-binding protein
CH46_1018	COG4214	carbohydrate transport
CH46_1019	COG2207	Transcriptional regulator
CH46_1019	COG1609	Transcriptional regulator
CH46_1021	COG0582	viral genome integration into host DNA
CH46_1028	COG4604	ABC transporter, ATP-binding protein
CH46_1030	COG4605	iron ion homeostasis
CH46_1032	COG4607	ABC-type enterochelin transport system periplasmic component
CH46_1035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH46_1038	COG2986	histidine ammonia-lyase
CH46_1041	COG2194	sulfuric ester hydrolase activity
CH46_1042	COG2197	response regulator
CH46_1043	COG3851	Histidine kinase
CH46_1048	COG2271	Major facilitator Superfamily
CH46_1052	COG2831	hemolysin activation secretion protein
CH46_1054	COG0747	negative chemotaxis
CH46_1055	COG0601	transmembrane transport
CH46_1056	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH46_1057	COG0444	Belongs to the ABC transporter superfamily
CH46_1058	COG4608	Belongs to the ABC transporter superfamily
CH46_1059	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CH46_1060	COG2199	diguanylate cyclase activity
CH46_1060	COG2200	EAL domain
CH46_1061	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH46_1066	COG0612	Peptidase, M16
CH46_1067	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH46_1068	COG1942	4-Oxalocrotonate Tautomerase
CH46_1069	COG2200	EAL domain
CH46_1070	COG2134	cdp-diacylglycerol pyrophosphatase
CH46_1071	COG2982	Protein involved in outer membrane biogenesis
CH46_1072	COG1295	ribonuclease BN
CH46_1077	COG1929	Belongs to the glycerate kinase type-1 family
CH46_1078	COG2610	gluconate transmembrane transporter activity
CH46_1079	COG3835	regulator
CH46_1080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH46_1081	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH46_1082	COG0339	signal peptide processing
CH46_1086	COG0589	response to stress
CH46_1088	COG1943	Transposase
CH46_1089	COG0306	phosphate transporter
CH46_1090	COG2081	HI0933 family
CH46_1093	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_1094	COG1879	ABC-type sugar transport system periplasmic component
CH46_1096	COG0191	fructose-bisphosphate aldolase activity
CH46_1098	COG0745	RESPONSE REGULATOR receiver
CH46_1100	COG1741	Belongs to the pirin family
CH46_1101	COG1609	Transcriptional regulator
CH46_1102	COG2610	gluconate transmembrane transporter activity
CH46_1103	COG3265	gluconokinase activity
CH46_1107	COG2095	MarC family integral membrane protein
CH46_1108	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH46_1118	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH46_1120	COG0058	SHG alpha-glucan phosphorylase activity
CH46_1121	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH46_1124	COG2801	Transposase and inactivated derivatives
CH46_1131	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CH46_1135	COG1629	transport
CH46_1140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH46_1141	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH46_1141	COG0678	peroxiredoxin activity
CH46_115	COG0840	transmembrane signaling receptor activity
CH46_1156	COG1879	ABC-type sugar transport system periplasmic component
CH46_1157	COG1129	ABC transporter
CH46_1158	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_1160	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_1161	COG3085	chromosome segregation
CH46_1164	COG3978	acetolactate synthase activity
CH46_1165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH46_117	COG0583	DNA-binding transcription factor activity
CH46_1174	COG0583	DNA-binding transcription factor activity
CH46_118	COG0583	DNA-binding transcription factor activity
CH46_1181	COG3121	Chaperone
CH46_1184	COG3121	Chaperone
CH46_1186	COG3328	transposase activity
CH46_1188	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH46_119	COG2814	Major facilitator Superfamily
CH46_1193	COG3118	belongs to the thioredoxin family
CH46_1194	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH46_1195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH46_1196	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH46_1197	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH46_1198	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH46_1199	COG1088	dTDP-glucose 4,6-dehydratase activity
CH46_120	COG1609	Transcriptional regulator
CH46_1200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH46_1201	COG0456	acetyltransferase
CH46_1202	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH46_1203	COG2244	polysaccharide biosynthetic process
CH46_1207	COG1113	amino acid transport
CH46_121	COG0019	diaminopimelate decarboxylase activity
CH46_1213	COG1943	Transposase
CH46_1214	COG3071	HemY protein
CH46_1215	COG2959	enzyme of heme biosynthesis
CH46_1216	COG1587	Uroporphyrinogen-III synthase
CH46_1218	COG3072	Adenylate cyclase
CH46_1220	COG5567	small periplasmic lipoprotein
CH46_1222	COG3159	Protein conserved in bacteria
CH46_1223	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH46_1224	COG1011	Hydrolase
CH46_1225	COG0210	DNA helicase
CH46_1227	COG5441	Belongs to the UPF0261 family
CH46_1228	COG5564	TIM-barrel signal transduction protein
CH46_1229	COG0598	Magnesium transport protein CorA
CH46_1231	COG2050	protein possibly involved in aromatic compounds catabolism
CH46_1232	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CH46_1233	COG0514	ATP-dependent DNA helicase (RecQ)
CH46_1234	COG1280	lysine exporter protein (LysE YggA)
CH46_1235	COG1280	lysine exporter protein (LysE YggA)
CH46_1236	COG2267	carboxylic ester hydrolase activity
CH46_1237	COG0561	phosphatase activity
CH46_1239	COG0584	glycerophosphoryl diester phosphodiesterase
CH46_1240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH46_1242	COG0247	lactate metabolic process
CH46_1244	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH46_1247	COG3714	YhhN family
CH46_1250	COG3776	membrane
CH46_1251	COG0742	ribosomal rna small subunit methyltransferase
CH46_1252	COG0552	protein localization to endoplasmic reticulum
CH46_1252	COG0552	protein localization to endoplasmic reticulum
CH46_1253	COG2884	Cell division ATP-binding protein ftsE
CH46_1254	COG2177	Part of the ABC transporter FtsEX involved in
CH46_1256	COG1943	Transposase
CH46_1258	COG0683	leucine binding
CH46_1259	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH46_1260	COG4177	L-phenylalanine transmembrane transporter activity
CH46_1261	COG0411	ABC transporter
CH46_1262	COG0410	ABC transporter
CH46_127	COG0667	Aldo Keto reductase
CH46_1274	COG0584	glycerophosphoryl diester phosphodiesterase
CH46_1275	COG0679	Auxin Efflux Carrier
CH46_1276	COG0583	DNA-binding transcription factor activity
CH46_1279	COG0412	Dienelactone hydrolase
CH46_1280	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CH46_1282	COG1966	Carbon starvation protein
CH46_1283	COG0586	Pfam SNARE associated Golgi protein
CH46_1284	COG1322	Protein conserved in bacteria
CH46_1288	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH46_1290	COG0805	protein transport
CH46_1302	COG1739	Uncharacterized protein family UPF0029
CH46_1303	COG1943	Transposase
CH46_1304	COG1739	Uncharacterized protein family UPF0029
CH46_1305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH46_1306	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CH46_1313	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CH46_1324	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH46_1325	COG0250	Participates in transcription elongation, termination and antitermination
CH46_1332	COG1943	Transposase
CH46_1334	COG2022	thiamine diphosphate biosynthetic process
CH46_1336	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH46_1338	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CH46_1343	COG1515	deoxyribonuclease V activity
CH46_1344	COG3068	Protein conserved in bacteria
CH46_1347	COG0151	Belongs to the GarS family
CH46_1360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH46_1361	COG2224	Isocitrate lyase
CH46_1363	COG1414	Transcriptional regulator
CH46_1364	COG1414	Transcriptional regulator
CH46_1368	COG0527	aspartate kinase activity
CH46_1371	COG3833	ABC-type maltose transport systems, permease component
CH46_1372	COG1175	transmembrane transport
CH46_138	COG2226	methyltransferase
CH46_138	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH46_138	COG3433	isochorismatase activity
CH46_1383	COG2801	Transposase and inactivated derivatives
CH46_139	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH46_1399	COG3501	Rhs element vgr protein
CH46_140	COG3433	isochorismatase activity
CH46_140	COG2226	methyltransferase
CH46_140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH46_1402	COG3209	COG3209 Rhs family protein
CH46_1408	COG3501	Rhs element vgr protein
CH46_1410	COG3209	COG3209 Rhs family protein
CH46_1413	COG0673	inositol 2-dehydrogenase activity
CH46_1414	COG2207	Transcriptional regulator
CH46_1414	COG1917	Cupin 2, conserved barrel domain protein
CH46_1415	COG1869	D-ribose catabolic process
CH46_1416	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH46_1418	COG0431	NADPH-dependent FMN reductase
CH46_1419	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH46_1421	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH46_1423	COG3077	Addiction module antitoxin, RelB DinJ family
CH46_1424	COG2252	PERMEase
CH46_1425	COG0025	NhaP-type Na H and K H
CH46_1427	COG1560	Kdo2-lipid A biosynthetic process
CH46_1429	COG1129	ABC transporter
CH46_1430	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_1432	COG1069	ribulokinase activity
CH46_1434	COG0625	glutathione transferase activity
CH46_1437	COG1943	Transposase
CH46_1438	COG1278	Cold shock
CH46_1439	COG1278	Cold shock
CH46_1440	COG3133	Outer membrane lipoprotein
CH46_1441	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH46_1443	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH46_1447	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH46_1448	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH46_1450	COG4145	pantothenate transmembrane transporter activity
CH46_1451	COG3924	membrane
CH46_1453	COG0439	Biotin carboxylase
CH46_1454	COG0511	ligase activity, forming carbon-carbon bonds
CH46_1457	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CH46_1458	COG0604	alcohol dehydrogenase
CH46_1459	COG2200	EAL domain
CH46_1459	COG2199	diguanylate cyclase activity
CH46_1460	COG1077	Cell shape determining protein MreB Mrl
CH46_1461	COG1792	Involved in formation and maintenance of cell shape
CH46_1462	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH46_1464	COG1530	ribonuclease E activity
CH46_1465	COG3164	Protein of unknown function
CH46_1466	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH46_1467	COG0312	modulator of DNA gyrase
CH46_147	COG1132	(ABC) transporter
CH46_1478	COG0583	DNA-binding transcription factor activity
CH46_1482	COG1012	belongs to the aldehyde dehydrogenase family
CH46_1485	COG2732	(Barnase) inhibitor
CH46_1487	COG0312	modulator of DNA gyrase
CH46_1489	COG3783	Cytochrome b(562)
CH46_1490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH46_1491	COG0366	Alpha amylase catalytic
CH46_1492	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH46_1492	COG1263	PTS System
CH46_1493	COG1609	Transcriptional regulator
CH46_1504	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH46_1506	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH46_1508	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH46_1509	COG1137	ATPase activity
CH46_151	COG2610	gluconate transmembrane transporter activity
CH46_1510	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH46_1511	COG3117	lipopolysaccharide transmembrane transporter activity
CH46_1512	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH46_1513	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH46_1513	COG0517	IMP dehydrogenase activity
CH46_1514	COG0530	calcium, potassium:sodium antiporter activity
CH46_1515	COG1127	ABC transporter
CH46_1516	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH46_1517	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH46_1518	COG2854	intermembrane phospholipid transfer
CH46_1519	COG3113	response to antibiotic
CH46_1520	COG5007	Belongs to the BolA IbaG family
CH46_1522	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH46_1523	COG1943	Transposase
CH46_1524	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH46_1525	COG3105	Protein conserved in bacteria
CH46_1526	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH46_1529	COG0625	glutathione transferase activity
CH46_1530	COG2969	positive regulation of protein catabolic process
CH46_1532	COG0493	'glutamate synthase
CH46_1533	COG0070	glutamate synthase
CH46_1533	COG0069	glutamate synthase activity
CH46_1533	COG0067	glutamate synthase
CH46_1534	COG1242	4 iron, 4 sulfur cluster binding
CH46_1535	COG2198	Histidine kinase
CH46_1535	COG5002	protein histidine kinase activity
CH46_1535	COG0784	Response regulator, receiver
CH46_1536	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH46_1538	COG2823	Periplasmic or secreted lipoprotein
CH46_154	COG3501	Rhs element vgr protein
CH46_1542	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH46_1543	COG1741	Belongs to the pirin family
CH46_1544	COG0583	DNA-binding transcription factor activity
CH46_1545	COG0435	Glutathione S-transferase
CH46_1548	COG1073	alpha beta
CH46_1550	COG0360	Binds together with S18 to 16S ribosomal RNA
CH46_1551	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH46_1553	COG1943	Transposase
CH46_1555	COG3061	Opacity-associated protein A
CH46_1556	COG0545	Peptidyl-prolyl cis-trans isomerase
CH46_1558	COG0737	Belongs to the 5'-nucleotidase family
CH46_156	COG3209	COG3209 Rhs family protein
CH46_1560	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH46_1562	COG1253	flavin adenine dinucleotide binding
CH46_1564	COG0729	surface antigen
CH46_1565	COG2911	Protein conserved in bacteria
CH46_1566	COG2105	PFAM AIG2 family protein
CH46_1567	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH46_1569	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH46_1573	COG3423	Transcriptional regulator
CH46_1575	COG0142	geranyltranstransferase activity
CH46_1578	COG0697	spore germination
CH46_1580	COG0642	Histidine kinase
CH46_1581	COG0745	RESPONSE REGULATOR receiver
CH46_1582	COG2027	D-alanyl-D-alanine carboxypeptidase
CH46_1583	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH46_1584	COG1534	Rna-binding protein
CH46_1586	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CH46_1587	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH46_1589	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH46_159	COG0471	metal ion transport
CH46_1593	COG0195	Participates in both transcription termination and antitermination
CH46_1599	COG2801	Transposase and inactivated derivatives
CH46_16	COG5295	Hep Hag repeat protein
CH46_1602	COG0513	Belongs to the DEAD box helicase family
CH46_1605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH46_1608	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH46_161	COG2801	Transposase and inactivated derivatives
CH46_1613	COG3153	acetyltransferase
CH46_1617	COG1653	transport
CH46_1619	COG0395	ABC-type sugar transport system, permease component
CH46_1620	COG3842	ATPase activity
CH46_1623	COG0702	epimerase
CH46_1624	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CH46_1625	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CH46_1626	COG3454	Phosphonate metabolism
CH46_1627	COG4778	phosphonate C-P lyase system protein PhnL
CH46_1628	COG4107	phosphonate C-P lyase system protein PhnK
CH46_1629	COG3627	carbon phosphorus lyase activity
CH46_1630	COG3626	phosphonate metabolism
CH46_1631	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CH46_1632	COG3624	Phosphonate C-P lyase system protein PhnG
CH46_1633	COG2188	Transcriptional regulator
CH46_1637	COG4608	Belongs to the ABC transporter superfamily
CH46_1638	COG0444	Belongs to the ABC transporter superfamily
CH46_1639	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH46_164	COG3133	Outer membrane lipoprotein
CH46_1640	COG0601	transmembrane transport
CH46_1643	COG2731	YhcH YjgK YiaL family protein
CH46_1644	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CH46_1645	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH46_1647	COG0525	valine-tRNA ligase activity
CH46_1648	COG2927	DNA polymerase III (CHI subunit)
CH46_165	COG3133	Outer membrane lipoprotein
CH46_1650	COG0795	lipopolysaccharide-transporting ATPase activity
CH46_1651	COG0795	lipopolysaccharide-transporting ATPase activity
CH46_1653	COG0582	viral genome integration into host DNA
CH46_1661	COG0237	dephospho-CoA kinase activity
CH46_1663	COG1459	type II secretion system
CH46_1664	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH46_1665	COG4969	Belongs to the N-Me-Phe pilin family
CH46_1667	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH46_1668	COG3725	Membrane protein required for beta-lactamase induction
CH46_1669	COG1113	amino acid transport
CH46_1670	COG2186	Transcriptional regulator
CH46_1671	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH46_1672	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH46_1673	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH46_1674	COG1943	Transposase
CH46_1675	COG1049	propionate catabolic process, 2-methylcitrate cycle
CH46_1677	COG0697	spore germination
CH46_1681	COG2132	Multicopper oxidase
CH46_1682	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH46_1683	COG0288	reversible hydration of carbon dioxide
CH46_1684	COG1131	(ABC) transporter
CH46_1685	COG0842	Transport permease protein
CH46_1686	COG0726	polysaccharide deacetylase
CH46_1690	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH46_1691	COG0617	tRNA 3'-terminal CCA addition
CH46_1692	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH46_1693	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH46_1695	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CH46_1696	COG1643	Atp-dependent helicase
CH46_1697	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH46_1698	COG1120	ATPase activity
CH46_1699	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH46_170	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CH46_1700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH46_1704	COG2860	membrane
CH46_1706	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH46_1708	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH46_1709	COG4999	Histidine kinase
CH46_1709	COG3850	Histidine kinase
CH46_1709	COG2205	protein histidine kinase activity
CH46_1709	COG3437	response regulator, receiver
CH46_171	COG1191	sigma factor activity
CH46_1710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH46_1711	COG3956	TIGRFAM MazG family protein
CH46_1715	COG0602	queuosine metabolic process
CH46_1716	COG0720	synthase
CH46_1731	COG0529	Catalyzes the synthesis of activated sulfate
CH46_1734	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CH46_1739	COG1388	LysM domain
CH46_1739	COG4942	peptidase
CH46_1740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH46_1741	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH46_1742	COG0698	ribose 5-phosphate isomerase
CH46_1743	COG1063	alcohol dehydrogenase
CH46_1744	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_1745	COG2376	Dihydroxyacetone kinase
CH46_1748	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH46_1752	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH46_1753	COG1858	cytochrome C peroxidase
CH46_1755	COG4771	TonB-dependent receptor
CH46_1758	COG0024	Methionine aminopeptidase
CH46_176	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CH46_1760	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH46_1760	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH46_1761	COG1070	Carbohydrate kinase
CH46_1762	COG3623	hexulose-6-phosphate isomerase
CH46_1763	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_1764	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_1765	COG1129	ABC transporter
CH46_1766	COG1943	Transposase
CH46_1768	COG1349	DNA-binding transcription factor activity
CH46_1769	COG0235	Class ii aldolase
CH46_1770	COG0243	molybdopterin cofactor binding
CH46_1771	COG0437	4 iron, 4 sulfur cluster binding
CH46_1772	COG3302	dmso reductase anchor subunit
CH46_1773	COG3381	protein complex oligomerization
CH46_1774	COG3038	cytochrome b561
CH46_1775	COG3783	Cytochrome b(562)
CH46_1779	COG1129	ABC transporter
CH46_1780	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_1781	COG3959	Transketolase, thiamine diphosphate binding domain
CH46_1782	COG3958	Transketolase
CH46_1783	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH46_1790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH46_1791	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH46_1796	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH46_1797	COG1238	metal cluster binding
CH46_1798	COG2918	glutathione biosynthetic process
CH46_18	COG1272	protein, Hemolysin III
CH46_180	COG3710	Transcriptional regulator
CH46_1800	COG1943	Transposase
CH46_1801	COG4536	flavin adenine dinucleotide binding
CH46_1802	COG4137	Cytochrome C assembly protein
CH46_1803	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH46_1808	COG1943	Transposase
CH46_1809	COG3137	Salt-induced outer membrane protein
CH46_1810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH46_1811	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH46_1812	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH46_1813	COG3279	Response regulator of the LytR AlgR family
CH46_1814	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH46_1815	COG1605	Chorismate mutase
CH46_1815	COG0287	Prephenate dehydrogenase
CH46_1816	COG1605	Chorismate mutase
CH46_1816	COG0077	Prephenate dehydratase
CH46_1820	COG0077	Prephenate dehydratase
CH46_1820	COG1605	Chorismate mutase
CH46_1821	COG1943	Transposase
CH46_1822	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH46_1823	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH46_1824	COG0564	pseudouridine synthase activity
CH46_1826	COG0542	response to heat
CH46_1833	COG5544	Lipoprotein
CH46_1834	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH46_1835	COG0045	succinate-CoA ligase (ADP-forming) activity
CH46_1835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH46_1835	COG1042	CoA-binding domain protein
CH46_1837	COG3118	belongs to the thioredoxin family
CH46_1838	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH46_1839	COG2814	Major facilitator Superfamily
CH46_184	COG1256	bacterial-type flagellum assembly
CH46_1840	COG1566	PFAM secretion protein HlyD family protein
CH46_1841	COG1846	Transcriptional regulator
CH46_1843	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH46_1844	COG2814	Major facilitator Superfamily
CH46_1853	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH46_1857	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH46_186	COG1706	bacterial-type flagellum-dependent cell motility
CH46_1861	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH46_1863	COG1960	acyl-CoA dehydrogenase activity
CH46_1865	COG3034	peptidoglycan biosynthetic process
CH46_1866	COG0121	glutamine amidotransferase
CH46_1867	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH46_1868	COG1805	sodium ion transport
CH46_1869	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH46_187	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CH46_1873	COG1477	protein flavinylation
CH46_1877	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH46_188	COG4786	Flagellar basal body rod
CH46_1888	COG2226	methyltransferase
CH46_1893	COG1940	carbohydrate kinase activity
CH46_1896	COG0419	ATPase involved in DNA repair
CH46_1897	COG0420	3'-5' exonuclease activity
CH46_1898	COG0745	RESPONSE REGULATOR receiver
CH46_1899	COG5002	protein histidine kinase activity
CH46_190	COG1943	Transposase
CH46_1901	COG1114	Component of the transport system for branched-chain amino acids
CH46_1903	COG0366	Alpha amylase catalytic
CH46_1907	COG1943	Transposase
CH46_1908	COG0450	alkyl hydroperoxide reductase
CH46_1909	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH46_1910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CH46_1912	COG1862	Preprotein translocase
CH46_1913	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH46_1914	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH46_1918	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH46_1918	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH46_192	COG1749	Flagellar hook protein flgE
CH46_1921	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH46_1922	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH46_1923	COG1943	Transposase
CH46_1925	COG0142	geranyltranstransferase activity
CH46_1928	COG0693	protein deglycase activity
CH46_1929	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH46_193	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH46_1931	COG2814	Major facilitator Superfamily
CH46_1933	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH46_1934	COG1845	cytochrome c oxidase, subunit III
CH46_1935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH46_1936	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH46_1938	COG2223	nitrite transmembrane transporter activity
CH46_1939	COG3056	Lipoprotein
CH46_194	COG1558	bacterial-type flagellum-dependent cell motility
CH46_1940	COG0271	Belongs to the BolA IbaG family
CH46_1945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH46_1946	COG0776	regulation of translation
CH46_1947	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH46_1948	COG1555	photosystem II stabilization
CH46_1949	COG0824	Thioesterase
CH46_195	COG1815	bacterial-type flagellum-dependent cell motility
CH46_1951	COG4533	DNA binding
CH46_1954	COG1522	sequence-specific DNA binding
CH46_1955	COG1132	(ABC) transporter
CH46_1956	COG1132	(ABC) transporter
CH46_1957	COG0347	Belongs to the P(II) protein family
CH46_1958	COG0004	ammonium transporteR
CH46_1959	COG1946	Acyl-CoA thioesterase
CH46_196	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CH46_1960	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH46_1961	COG3695	enzyme binding
CH46_1965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH46_1967	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH46_1968	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH46_1969	COG1309	transcriptional regulator
CH46_1970	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH46_1971	COG3264	Mechanosensitive ion channel
CH46_1971	COG1196	nuclear chromosome segregation
CH46_1973	COG2832	Protein of unknown function (DUF454)
CH46_1977	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CH46_1983	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH46_1983	COG0543	2 iron, 2 sulfur cluster binding
CH46_1987	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH46_1996	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH46_1997	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH46_2003	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH46_2004	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH46_2005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH46_2005	COG4651	solute:proton antiporter activity
CH46_2006	COG2223	nitrite transmembrane transporter activity
CH46_2007	COG0737	Belongs to the 5'-nucleotidase family
CH46_2008	COG0737	Belongs to the 5'-nucleotidase family
CH46_2009	COG0737	Belongs to the 5'-nucleotidase family
CH46_2012	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH46_2013	COG3735	TraB family
CH46_2014	COG2217	Heavy metal translocating P-type atpase
CH46_2015	COG0789	Transcriptional regulator
CH46_2016	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH46_2017	COG0330	HflC and HflK could
CH46_2018	COG3118	belongs to the thioredoxin family
CH46_2019	COG0300	oxidoreductase activity
CH46_2020	COG2755	lipolytic protein G-D-S-L family
CH46_2021	COG4181	ATPase activity
CH46_2022	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH46_2023	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH46_2024	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH46_2026	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH46_2029	COG1943	Transposase
CH46_2031	COG1393	Belongs to the ArsC family
CH46_2032	COG4783	chaperone-mediated protein folding
CH46_2033	COG0628	permease
CH46_2036	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH46_2037	COG2716	regulation of RNA biosynthetic process
CH46_2039	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH46_2040	COG1943	Transposase
CH46_2042	COG2321	neutral zinc metallopeptidase
CH46_2046	COG1876	peptidase activity
CH46_2048	COG1393	Belongs to the ArsC family
CH46_205	COG2204	response regulator
CH46_2050	COG1840	ABC-type Fe3 transport system, periplasmic component
CH46_2051	COG1175	transmembrane transport
CH46_2052	COG3842	ATPase activity
CH46_2053	COG3119	arylsulfatase activity
CH46_2054	COG0641	radical SAM
CH46_2055	COG1988	membrane-bound metal-dependent
CH46_2057	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH46_2059	COG2197	response regulator
CH46_2060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH46_2060	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH46_2061	COG3062	negative regulation of establishment of protein localization
CH46_2063	COG3043	anaerobic respiration
CH46_2064	COG3005	denitrification pathway
CH46_2073	COG3111	PFAM Bacterial OB fold (BOF) protein
CH46_2075	COG2837	iron assimilation
CH46_2076	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH46_2078	COG4886	Leucine-rich repeat (LRR) protein
CH46_2080	COG2731	YhcH YjgK YiaL family protein
CH46_2081	COG1737	Transcriptional regulator
CH46_2083	COG4150	thiosulfate binding
CH46_2084	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH46_2085	COG4208	sulfate ABC transporter
CH46_2086	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CH46_2089	COG0745	RESPONSE REGULATOR receiver
CH46_209	COG1987	bacterial-type flagellum assembly
CH46_2090	COG3850	Histidine kinase
CH46_2090	COG5002	protein histidine kinase activity
CH46_2092	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH46_2094	COG0006	proline dipeptidase activity
CH46_2096	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH46_2099	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH46_21	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CH46_210	COG1684	flagellar biosynthetic protein fliR
CH46_2102	COG2205	protein histidine kinase activity
CH46_2106	COG1943	Transposase
CH46_2107	COG2190	(PTS) system
CH46_2109	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH46_211	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH46_2110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CH46_2111	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CH46_2114	COG3530	Putative quorum-sensing-regulated virulence factor
CH46_2119	COG1943	Transposase
CH46_2124	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH46_2127	COG0667	Aldo Keto reductase
CH46_2132	COG0436	Aminotransferase
CH46_2133	COG3038	cytochrome b561
CH46_2139	COG3381	protein complex oligomerization
CH46_2140	COG3302	dmso reductase anchor subunit
CH46_2141	COG0437	4 iron, 4 sulfur cluster binding
CH46_2142	COG0243	molybdopterin cofactor binding
CH46_2149	COG2951	lytic endotransglycosylase activity
CH46_216	COG4592	Periplasmic binding protein
CH46_2161	COG3121	Chaperone
CH46_2162	COG3188	usher protein
CH46_2163	COG3328	transposase activity
CH46_2164	COG3188	usher protein
CH46_2174	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH46_2176	COG1943	Transposase
CH46_2177	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH46_2178	COG1737	Transcriptional regulator
CH46_2180	COG0560	Phosphoserine phosphatase
CH46_2181	COG0590	tRNA wobble adenosine to inosine editing
CH46_2187	COG1943	Transposase
CH46_2188	COG2205	protein histidine kinase activity
CH46_2189	COG3170	Tfp pilus assembly protein FimV
CH46_2190	COG2204	response regulator
CH46_2191	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH46_2191	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH46_2192	COG0347	Belongs to the P(II) protein family
CH46_2195	COG1017	nitric oxide dioxygenase activity
CH46_2195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH46_2198	COG3711	transcriptional antiterminator
CH46_2199	COG2814	Major facilitator Superfamily
CH46_22	COG0745	RESPONSE REGULATOR receiver
CH46_220	COG1943	Transposase
CH46_2200	COG3683	transport system, periplasmic component
CH46_2201	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH46_2202	COG1943	Transposase
CH46_2203	COG0483	inositol monophosphate 1-phosphatase activity
CH46_2206	COG1104	cysteine desulfurase activity
CH46_2207	COG0822	iron-sulfur transferase activity
CH46_221	COG1943	Transposase
CH46_2210	COG0443	Heat shock 70 kDa protein
CH46_2211	COG0633	Ferredoxin
CH46_2212	COG2975	iron-sulfur cluster assembly
CH46_2216	COG3468	outer membrane autotransporter barrel domain protein
CH46_2217	COG3468	outer membrane autotransporter barrel domain protein
CH46_2225	COG2976	Protein conserved in bacteria
CH46_2226	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH46_2229	COG1645	bacterial-type flagellum-dependent swarming motility
CH46_2231	COG0517	IMP dehydrogenase activity
CH46_2231	COG0516	GMP reductase activity
CH46_2233	COG1943	Transposase
CH46_224	COG4964	Belongs to the GSP D family
CH46_2240	COG3328	transposase activity
CH46_2241	COG3328	transposase activity
CH46_2244	COG0351	phosphomethylpyrimidine kinase
CH46_225	COG4964	Belongs to the GSP D family
CH46_2250	COG3422	double-strand break repair
CH46_2251	COG0745	RESPONSE REGULATOR receiver
CH46_2252	COG2205	protein histidine kinase activity
CH46_2257	COG3842	ATPase activity
CH46_2259	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CH46_2261	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH46_2262	COG1177	transmembrane transport
CH46_2263	COG0443	Heat shock 70 kDa protein
CH46_2264	COG2239	Acts as a magnesium transporter
CH46_2265	COG0248	Ppx GppA phosphatase
CH46_2266	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH46_2268	COG0581	inorganic phosphate transmembrane transporter activity
CH46_2272	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH46_2273	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH46_2276	COG1943	Transposase
CH46_2277	COG2501	S4 domain
CH46_2285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH46_2286	COG4589	Belongs to the CDS family
CH46_2288	COG2267	carboxylic ester hydrolase activity
CH46_2289	COG2453	phosphatase
CH46_2289	COG0671	phosphoesterase, PA-phosphatase related
CH46_2298	COG0667	Aldo Keto reductase
CH46_2299	COG0656	L-ascorbic acid biosynthetic process
CH46_23	COG2205	protein histidine kinase activity
CH46_2305	COG3328	transposase activity
CH46_2306	COG2850	peptidyl-arginine hydroxylation
CH46_2315	COG3423	Transcriptional regulator
CH46_2316	COG4953	penicillin-binding protein 1C
CH46_2317	COG3328	transposase activity
CH46_2318	COG3328	transposase activity
CH46_2319	COG3037	sugar-specific permease SgaT UlaA
CH46_2320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH46_2321	COG0622	Phosphoesterase
CH46_2323	COG1090	epimerase
CH46_2324	COG4598	ABC transporter
CH46_2325	COG4160	amino acid transport
CH46_2326	COG4215	(ABC) transporter
CH46_2327	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH46_2328	COG0163	prenyltransferase activity
CH46_2329	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH46_2330	COG1286	toxin biosynthetic process
CH46_2331	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH46_2332	COG0285	dihydrofolate synthase activity
CH46_2334	COG0586	Pfam SNARE associated Golgi protein
CH46_2336	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH46_2337	COG1943	Transposase
CH46_2340	COG0697	spore germination
CH46_2343	COG1794	racemase activity, acting on amino acids and derivatives
CH46_2344	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH46_2347	COG3101	peptidyl-lysine hydroxylation
CH46_2348	COG0730	response to heat
CH46_2349	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH46_235	COG0848	biopolymer transport protein
CH46_2351	COG2890	protein-(glutamine-N5) methyltransferase activity
CH46_2353	COG2062	phosphohistidine phosphatase, SixA
CH46_2356	COG3691	Protein conserved in bacteria
CH46_2359	COG3088	subunit of a heme lyase
CH46_2359	COG4235	cytochrome complex assembly
CH46_2360	COG3088	subunit of a heme lyase
CH46_2360	COG4235	cytochrome complex assembly
CH46_2361	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH46_2362	COG1138	Cytochrome C-type biogenesis protein
CH46_2364	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH46_2365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH46_2366	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH46_237	COG0811	peptide transport
CH46_2370	COG1704	LemA family
CH46_2372	COG2824	Alkylphosphonate utilization operon protein PhnA
CH46_2378	COG3501	Rhs element vgr protein
CH46_238	COG0626	cystathionine gamma-synthase activity
CH46_2387	COG0681	Belongs to the peptidase S26 family
CH46_239	COG0586	Pfam SNARE associated Golgi protein
CH46_2390	COG3086	response to oxidative stress
CH46_2391	COG3026	antisigma factor binding
CH46_2392	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH46_2394	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH46_2396	COG0513	Belongs to the DEAD box helicase family
CH46_24	COG4452	Inner membrane protein CreD
CH46_240	COG2207	Transcriptional regulator
CH46_2407	COG1984	allophanate hydrolase subunit 2
CH46_2408	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH46_241	COG1979	alcohol dehydrogenase
CH46_2410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH46_2411	COG5212	phosphodiesterase
CH46_2413	COG3272	Protein of unknown function (DUF1722)
CH46_2418	COG2205	protein histidine kinase activity
CH46_2419	COG0745	RESPONSE REGULATOR receiver
CH46_242	COG0656	L-ascorbic acid biosynthetic process
CH46_2423	COG0033	Phosphoglucomutase
CH46_2424	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH46_2428	COG2169	Transcriptional regulator
CH46_2428	COG1917	Cupin 2, conserved barrel domain protein
CH46_2429	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH46_2430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH46_2431	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH46_2432	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH46_2433	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH46_2434	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH46_2436	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH46_2437	COG4413	Urea transporter
CH46_2439	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH46_2446	COG1124	(ABC) transporter
CH46_2447	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH46_2448	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH46_245	COG2132	Multicopper oxidase
CH46_2450	COG0747	negative chemotaxis
CH46_2451	COG1278	Cold shock
CH46_2453	COG3328	transposase activity
CH46_2454	COG3328	transposase activity
CH46_246	COG0204	Acyl-transferase
CH46_2462	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH46_2463	COG4175	Glycine betaine
CH46_2464	COG4176	ABC-type proline glycine betaine transport system permease component
CH46_2465	COG2113	Glycine betaine
CH46_247	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH46_2470	COG0582	viral genome integration into host DNA
CH46_2471	COG2963	transposase activity
CH46_2473	COG0596	Alpha beta hydrolase
CH46_2477	COG0735	belongs to the Fur family
CH46_248	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH46_2482	COG1943	Transposase
CH46_2483	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH46_2483	COG2190	(PTS) system
CH46_2483	COG1263	PTS System
CH46_2485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH46_2486	COG1940	carbohydrate kinase activity
CH46_2486	COG1846	Transcriptional regulator
CH46_2487	COG0647	UMP catabolic process
CH46_2488	COG0367	asparagine synthase
CH46_249	COG0583	DNA-binding transcription factor activity
CH46_2494	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH46_2496	COG1702	phosphate starvation-inducible protein PhoH
CH46_2498	COG4535	Mg2 and Co2 transporter CorC
CH46_2499	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH46_25	COG0716	FMN binding
CH46_250	COG0187	DNA topoisomerase II activity
CH46_2501	COG0765	amino acid transport
CH46_2502	COG0765	amino acid transport
CH46_2503	COG1126	abc transporter atp-binding protein
CH46_2504	COG2888	peptidyl-tyrosine sulfation
CH46_2507	COG1466	dna polymerase III delta subunit
CH46_2509	COG0799	negative regulation of ribosome biogenesis
CH46_251	COG3150	esterase
CH46_2511	COG0768	penicillin binding
CH46_2512	COG0772	Belongs to the SEDS family
CH46_2513	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH46_2514	COG1686	Belongs to the peptidase S11 family
CH46_2518	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH46_2519	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH46_252	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH46_2520	COG1278	Cold shock
CH46_2522	COG2197	response regulator
CH46_2527	COG5265	(ABC) transporter
CH46_2529	COG3718	enzyme involved in inositol metabolism
CH46_253	COG3151	Protein conserved in bacteria
CH46_2531	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH46_2532	COG0673	inositol 2-dehydrogenase activity
CH46_2533	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_2534	COG1129	ABC transporter
CH46_2535	COG1879	ABC-type sugar transport system periplasmic component
CH46_2536	COG0673	inositol 2-dehydrogenase activity
CH46_2537	COG0673	inositol 2-dehydrogenase activity
CH46_2538	COG3962	Belongs to the TPP enzyme family
CH46_254	COG0494	nUDIX hydrolase
CH46_2544	COG2373	Large extracellular alpha-helical protein
CH46_2545	COG4953	penicillin-binding protein 1C
CH46_2546	COG3328	transposase activity
CH46_2549	COG1609	Transcriptional regulator
CH46_255	COG1538	Outer membrane efflux protein
CH46_2550	COG0857	belongs to the CobB CobQ family
CH46_2550	COG0280	phosphate acetyltransferase
CH46_2554	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH46_2555	COG0471	metal ion transport
CH46_2555	COG0490	domain, Protein
CH46_2557	COG0436	Aminotransferase
CH46_2558	COG0583	DNA-binding transcription factor activity
CH46_2560	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH46_2562	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CH46_2564	COG1034	ATP synthesis coupled electron transport
CH46_2567	COG0839	Belongs to the complex I subunit 6 family
CH46_2569	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH46_2570	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH46_2573	COG2731	YhcH YjgK YiaL family protein
CH46_2574	COG3265	gluconokinase activity
CH46_2575	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_2577	COG1609	Transcriptional regulator
CH46_2578	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH46_258	COG0754	glutathionylspermidine amidase activity
CH46_2581	COG0129	dihydroxy-acid dehydratase activity
CH46_2583	COG4575	ribosome binding
CH46_2585	COG1169	isochorismate synthase
CH46_2588	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH46_259	COG3384	dioxygenase
CH46_2591	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH46_2599	COG1126	abc transporter atp-binding protein
CH46_26	COG4974	Belongs to the 'phage' integrase family
CH46_2600	COG0765	amino acid transport
CH46_2601	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH46_2607	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH46_2611	COG1063	alcohol dehydrogenase
CH46_2612	COG1879	ABC-type sugar transport system periplasmic component
CH46_2613	COG1129	ABC transporter
CH46_2614	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_2615	COG1609	Transcriptional regulator
CH46_2616	COG0583	DNA-binding transcription factor activity
CH46_2617	COG0473	3-isopropylmalate dehydrogenase activity
CH46_2618	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CH46_2619	COG4638	Rieske (2fe-2S)
CH46_2620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH46_2621	COG2831	hemolysin activation secretion protein
CH46_2622	COG3210	domain, Protein
CH46_2625	COG3210	domain, Protein
CH46_2628	COG3210	domain, Protein
CH46_263	COG0531	amino acid
CH46_2630	COG3842	ATPase activity
CH46_2632	COG1609	Transcriptional regulator
CH46_2635	COG0395	ABC-type sugar transport system, permease component
CH46_2636	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CH46_2640	COG0668	transmembrane transport
CH46_2641	COG1518	maintenance of DNA repeat elements
CH46_2642	COG1203	CRISPR-associated helicase, Cas3
CH46_2647	COG0667	Aldo Keto reductase
CH46_2649	COG0477	Major facilitator Superfamily
CH46_2651	COG0583	DNA-binding transcription factor activity
CH46_2652	COG3916	Acyl-homoserine-lactone synthase
CH46_2653	COG2771	luxR family
CH46_2657	COG0628	permease
CH46_266	COG3025	triphosphatase activity
CH46_2660	COG3328	transposase activity
CH46_2661	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH46_2664	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH46_2665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH46_2666	COG1121	(ABC) transporter
CH46_2667	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH46_267	COG4991	sh3 domain protein
CH46_2671	COG4249	Peptidase C14 caspase catalytic subunit p20
CH46_2676	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CH46_2677	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH46_2677	COG0072	phenylalanine-tRNA ligase activity
CH46_2678	COG0776	regulation of translation
CH46_2681	COG0386	Belongs to the glutathione peroxidase family
CH46_2682	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH46_2690	COG0791	NLP P60 protein
CH46_2696	COG0574	Belongs to the PEP-utilizing enzyme family
CH46_2696	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH46_2697	COG0628	permease
CH46_2698	COG0277	FAD linked oxidase domain protein
CH46_2698	COG0247	lactate metabolic process
CH46_2699	COG2050	protein possibly involved in aromatic compounds catabolism
CH46_27	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH46_270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH46_2700	COG0316	Belongs to the HesB IscA family
CH46_2701	COG0719	Fe-S assembly protein
CH46_2702	COG0396	ATPase activity
CH46_2703	COG0719	Fe-S assembly protein
CH46_2706	COG1376	ErfK ybiS ycfS ynhG family protein
CH46_2706	COG1388	LysM domain
CH46_2708	COG1943	Transposase
CH46_2709	COG4238	major outer membrane lipoprotein
CH46_2714	COG0307	riboflavin synthase, alpha
CH46_2717	COG2814	Major facilitator Superfamily
CH46_2718	COG0583	DNA-binding transcription factor activity
CH46_2721	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH46_2722	COG0791	NLP P60 protein
CH46_2724	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH46_2725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH46_2726	COG0346	lactoylglutathione lyase activity
CH46_2728	COG1902	pentaerythritol trinitrate reductase activity
CH46_2729	COG1309	transcriptional regulator
CH46_2730	COG2194	sulfuric ester hydrolase activity
CH46_2731	COG3313	Fe-S protein
CH46_2732	COG4989	oxidoreductase activity
CH46_2734	COG3133	Outer membrane lipoprotein
CH46_2736	COG3895	Periplasmic Protein
CH46_274	COG0358	DNA primase activity
CH46_2740	COG0625	glutathione transferase activity
CH46_2744	COG3104	oligopeptide transport
CH46_2746	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH46_2746	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH46_2747	COG4172	Belongs to the ABC transporter superfamily
CH46_2749	COG4171	peptide transport system, permease
CH46_275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH46_2750	COG4168	peptide transport system, permease
CH46_2751	COG4166	transmembrane transport
CH46_2752	COG1943	Transposase
CH46_2753	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH46_2754	COG1842	Phage shock protein A
CH46_2756	COG1983	PspC domain protein
CH46_2758	COG3106	COG3106 Predicted ATPase
CH46_2763	COG1943	Transposase
CH46_2764	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH46_2765	COG4948	Mandelate Racemase Muconate Lactonizing
CH46_2766	COG2866	Carboxypeptidase
CH46_2767	COG4166	transmembrane transport
CH46_2770	COG2755	lipolytic protein G-D-S-L family
CH46_2770	COG0657	acetylesterase activity
CH46_2773	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH46_2773	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH46_2773	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH46_2773	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH46_2775	COG1285	pathogenesis
CH46_2776	COG3042	response to heat
CH46_2777	COG3187	Heat shock protein
CH46_2778	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH46_2779	COG2911	Protein conserved in bacteria
CH46_2781	COG3784	Protein of unknown function (DUF1318)
CH46_2782	COG0246	Mannitol dehydrogenase
CH46_2783	COG2390	Transcriptional regulator
CH46_2785	COG1643	Atp-dependent helicase
CH46_2788	COG3591	Belongs to the peptidase S1B family
CH46_2790	COG3038	cytochrome b561
CH46_2794	COG1943	Transposase
CH46_2795	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH46_2796	COG2205	protein histidine kinase activity
CH46_2797	COG0745	RESPONSE REGULATOR receiver
CH46_2799	COG0531	amino acid
CH46_28	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH46_2801	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH46_2802	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH46_2803	COG0589	response to stress
CH46_2804	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH46_2805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH46_2809	COG1011	Hydrolase
CH46_2810	COG0440	acetolactate synthase activity
CH46_2811	COG0028	Belongs to the TPP enzyme family
CH46_2816	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH46_2817	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH46_2818	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH46_2819	COG1879	ABC-type sugar transport system periplasmic component
CH46_2821	COG1609	Transcriptional regulator
CH46_2825	COG4128	Pfam Zonular occludens toxin
CH46_2833	COG4128	Pfam Zonular occludens toxin
CH46_2843	COG0038	chloride channel
CH46_2844	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH46_2846	COG1940	carbohydrate kinase activity
CH46_2847	COG0583	DNA-binding transcription factor activity
CH46_2848	COG2814	Major facilitator Superfamily
CH46_2850	COG0114	fumarate hydratase activity
CH46_2852	COG5339	Protein conserved in bacteria
CH46_2854	COG0385	Bile acid
CH46_2855	COG0673	inositol 2-dehydrogenase activity
CH46_2857	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_2859	COG1879	ABC-type sugar transport system periplasmic component
CH46_2863	COG2274	protein secretion by the type I secretion system
CH46_2864	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH46_2871	COG3708	Transcriptional regulator
CH46_2871	COG2207	Transcriptional regulator
CH46_2872	COG4658	electron transport chain
CH46_2873	COG4659	FMN binding
CH46_2875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH46_2876	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH46_2877	COG2271	Major facilitator Superfamily
CH46_2879	COG1966	Carbon starvation protein
CH46_2880	COG2879	small protein
CH46_2881	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH46_2885	COG0023	Translation Initiation Factor
CH46_2888	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH46_2889	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH46_2890	COG0671	phosphoesterase, PA-phosphatase related
CH46_2891	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH46_2892	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CH46_2894	COG0583	DNA-binding transcription factor activity
CH46_2895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH46_2897	COG0616	signal peptide processing
CH46_2898	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_2900	COG1187	pseudouridine synthase activity
CH46_2901	COG0009	L-threonylcarbamoyladenylate synthase
CH46_2904	COG0512	Glutamine amidotransferase of anthranilate synthase
CH46_2906	COG0135	phosphoribosylanthranilate isomerase activity
CH46_2906	COG0134	indole-3-glycerol-phosphate synthase activity
CH46_2910	COG3047	cAMP biosynthetic process
CH46_2915	COG1607	acyl-coa hydrolase
CH46_2917	COG3328	transposase activity
CH46_2918	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH46_2919	COG2350	Protein conserved in bacteria
CH46_292	COG0251	oxidation-reduction process
CH46_2926	COG4608	Belongs to the ABC transporter superfamily
CH46_2927	COG0444	Belongs to the ABC transporter superfamily
CH46_2928	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH46_2929	COG0601	transmembrane transport
CH46_2931	COG2095	MarC family integral membrane protein
CH46_2932	COG1012	belongs to the aldehyde dehydrogenase family
CH46_2932	COG1454	alcohol dehydrogenase
CH46_2935	COG1435	thymidine kinase activity
CH46_2938	COG0745	RESPONSE REGULATOR receiver
CH46_2940	COG3328	transposase activity
CH46_2941	COG0788	formyltetrahydrofolate deformylase activity
CH46_2944	COG0583	DNA-binding transcription factor activity
CH46_2945	COG0708	Exodeoxyribonuclease III
CH46_2946	COG0494	nUDIX hydrolase
CH46_2948	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH46_2949	COG0709	Synthesizes selenophosphate from selenide and ATP
CH46_2950	COG0778	Nitroreductase
CH46_2951	COG0616	signal peptide processing
CH46_2952	COG0252	asparaginase activity
CH46_2953	COG1335	isochorismatase
CH46_2954	COG3139	Protein of unknown function (DUF1315)
CH46_2958	COG3713	MltA-interacting MipA family protein
CH46_2959	COG2766	serine protein kinase
CH46_2962	COG0583	DNA-binding transcription factor activity
CH46_2964	COG2814	Major facilitator Superfamily
CH46_2966	COG2719	SpoVR family
CH46_2972	COG1104	cysteine desulfurase activity
CH46_2974	COG3328	transposase activity
CH46_2990	COG1943	Transposase
CH46_3	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH46_300	COG1289	transmembrane transporter activity
CH46_3006	COG3328	transposase activity
CH46_3027	COG0582	viral genome integration into host DNA
CH46_3029	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH46_3030	COG2951	lytic endotransglycosylase activity
CH46_3033	COG2894	cell division
CH46_3034	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH46_3035	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH46_3036	COG0318	PFAM AMP-dependent synthetase and ligase
CH46_3037	COG3065	identical protein binding
CH46_3039	COG1199	ATP-dependent helicase activity
CH46_304	COG0395	ABC-type sugar transport system, permease component
CH46_3040	COG0251	oxidation-reduction process
CH46_3043	COG0800	Aldolase
CH46_3045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH46_3046	COG1737	Transcriptional regulator
CH46_3047	COG0469	pyruvate kinase activity
CH46_3048	COG1560	Kdo2-lipid A biosynthetic process
CH46_3049	COG0739	heme binding
CH46_3050	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH46_3052	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH46_3057	COG0494	nUDIX hydrolase
CH46_3059	COG1801	Protein of unknown function DUF72
CH46_306	COG1653	transport
CH46_3060	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH46_3064	COG3102	Protein conserved in bacteria
CH46_3068	COG0728	peptidoglycan biosynthetic process
CH46_3069	COG0673	inositol 2-dehydrogenase activity
CH46_307	COG1609	Transcriptional regulator
CH46_3070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH46_3073	COG3381	protein complex oligomerization
CH46_3076	COG1940	carbohydrate kinase activity
CH46_3077	COG0584	glycerophosphoryl diester phosphodiesterase
CH46_3078	COG3842	ATPase activity
CH46_3079	COG1943	Transposase
CH46_308	COG3459	Glycosyltransferase 36 associated
CH46_3081	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH46_3082	COG3833	ABC-type maltose transport systems, permease component
CH46_3086	COG0659	secondary active sulfate transmembrane transporter activity
CH46_3089	COG0659	secondary active sulfate transmembrane transporter activity
CH46_309	COG3842	ATPase activity
CH46_3090	COG1943	Transposase
CH46_3092	COG2912	Transglutaminase-like superfamily
CH46_3093	COG3094	Invasion gene expression up-regulator, SirB
CH46_3094	COG2890	protein-(glutamine-N5) methyltransferase activity
CH46_3099	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH46_3102	COG0012	GTP binding
CH46_3113	COG5002	protein histidine kinase activity
CH46_3122	COG0500	methyltransferase
CH46_3127	COG3328	transposase activity
CH46_313	COG3210	domain, Protein
CH46_3136	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH46_3137	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CH46_3138	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CH46_3141	COG0402	S-adenosylhomocysteine deaminase activity
CH46_315	COG3210	domain, Protein
CH46_3155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH46_3156	COG3850	Histidine kinase
CH46_3157	COG0387	Pfam Sodium calcium exchanger
CH46_3158	COG1702	phosphate starvation-inducible protein PhoH
CH46_3161	COG3658	cytochrome
CH46_3162	COG1215	transferase activity, transferring glycosyl groups
CH46_3163	COG0726	polysaccharide deacetylase
CH46_3163	COG1649	PFAM Uncharacterised BCR, COG1649
CH46_3164	COG0457	Tetratricopeptide repeat
CH46_3165	COG0006	proline dipeptidase activity
CH46_3169	COG0577	efflux transmembrane transporter activity
CH46_3169	COG1136	(ABC) transporter
CH46_317	COG3210	domain, Protein
CH46_3171	COG1136	(ABC) transporter
CH46_3171	COG0577	efflux transmembrane transporter activity
CH46_3174	COG0672	)-iron permease
CH46_3176	COG2066	Belongs to the glutaminase family
CH46_3177	COG1349	DNA-binding transcription factor activity
CH46_3179	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH46_318	COG3210	domain, Protein
CH46_3180	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH46_3188	COG2030	dehydratase
CH46_3189	COG0427	acetyl-CoA hydrolase
CH46_319	COG2831	hemolysin activation secretion protein
CH46_3196	COG3188	usher protein
CH46_3198	COG3121	Chaperone
CH46_32	COG0582	viral genome integration into host DNA
CH46_320	COG4245	von Willebrand factor, type A
CH46_3200	COG0582	viral genome integration into host DNA
CH46_3201	COG1169	isochorismate synthase
CH46_3202	COG2814	Major facilitator Superfamily
CH46_3203	COG1132	(ABC) transporter
CH46_3206	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH46_3206	COG2226	methyltransferase
CH46_3206	COG3433	isochorismatase activity
CH46_3210	COG1021	2,3-dihydroxybenzoate-AMP ligase
CH46_3211	COG4771	TonB-dependent receptor
CH46_3224	COG0395	ABC-type sugar transport system, permease component
CH46_3225	COG1175	transmembrane transport
CH46_3227	COG0673	inositol 2-dehydrogenase activity
CH46_323	COG4245	von Willebrand factor, type A
CH46_3234	COG3328	transposase activity
CH46_3235	COG3328	transposase activity
CH46_3258	COG2197	response regulator
CH46_326	COG3247	response to pH
CH46_3260	COG3136	membrane protein required for alginate biosynthesis
CH46_3264	COG1113	amino acid transport
CH46_3267	COG2837	iron assimilation
CH46_327	COG1902	pentaerythritol trinitrate reductase activity
CH46_327	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH46_3272	COG0506	proline dehydrogenase activity
CH46_3272	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH46_3272	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH46_3278	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH46_3280	COG1191	sigma factor activity
CH46_3286	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CH46_3287	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH46_3288	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CH46_3291	COG1677	Flagellar hook-basal body complex protein FliE
CH46_3293	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH46_3295	COG1157	protein secretion by the type III secretion system
CH46_3296	COG2882	bacterial-type flagellum organization
CH46_3298	COG1580	Controls the rotational direction of flagella during chemotaxis
CH46_330	COG1451	nucleotide metabolic process
CH46_3303	COG1987	bacterial-type flagellum assembly
CH46_3307	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH46_3308	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_3309	COG1129	ABC transporter
CH46_331	COG0673	inositol 2-dehydrogenase activity
CH46_3311	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_3313	COG3347	Dehydrogenase
CH46_3313	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_3314	COG2390	Transcriptional regulator
CH46_3316	COG1256	bacterial-type flagellum assembly
CH46_3320	COG4786	Flagellar basal body rod
CH46_3322	COG1749	Flagellar hook protein flgE
CH46_3323	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH46_3324	COG1558	bacterial-type flagellum-dependent cell motility
CH46_3325	COG1815	bacterial-type flagellum-dependent cell motility
CH46_3327	COG2747	anti-sigma28 factor FlgM
CH46_3328	COG3418	PFAM FlgN family protein
CH46_3330	COG1943	Transposase
CH46_3333	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH46_3334	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH46_3339	COG2372	response to copper ion
CH46_334	COG1943	Transposase
CH46_3340	COG1528	Iron-storage protein
CH46_3343	COG1770	oligopeptidase
CH46_3346	COG3141	response to X-ray
CH46_3347	COG0513	Belongs to the DEAD box helicase family
CH46_3352	COG1760	l-serine dehydratase
CH46_3353	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CH46_3354	COG2368	4-hydroxyphenylacetate
CH46_3357	COG3971	2-oxopent-4-enoate hydratase activity
CH46_3359	COG3384	dioxygenase
CH46_336	COG2721	sulfolactate sulfo-lyase activity
CH46_3360	COG1012	belongs to the aldehyde dehydrogenase family
CH46_3363	COG1846	Transcriptional regulator
CH46_3364	COG1253	flavin adenine dinucleotide binding
CH46_3365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH46_3365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH46_3366	COG3715	PTS system
CH46_3367	COG3716	PTS system mannose fructose sorbose family IID component
CH46_337	COG0246	Mannitol dehydrogenase
CH46_3371	COG5002	protein histidine kinase activity
CH46_3371	COG5001	Diguanylate cyclase
CH46_3371	COG3447	MASE1 domain protein
CH46_3373	COG2226	methyltransferase
CH46_3375	COG1278	Cold shock
CH46_3378	COG1113	amino acid transport
CH46_3385	COG2207	Transcriptional regulator
CH46_3387	COG1132	(ABC) transporter
CH46_339	COG2271	Major facilitator Superfamily
CH46_3396	COG3328	transposase activity
CH46_3397	COG1917	Cupin 2, conserved barrel domain protein
CH46_3399	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_3401	COG1175	transmembrane transport
CH46_3402	COG0395	ABC-type sugar transport system, permease component
CH46_3403	COG3842	ATPase activity
CH46_3404	COG1653	transport
CH46_3405	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH46_3406	COG1988	membrane-bound metal-dependent
CH46_3408	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH46_3410	COG0823	Involved in the tonB-independent uptake of proteins
CH46_3411	COG2814	Major facilitator Superfamily
CH46_3412	COG3121	Chaperone
CH46_3415	COG3121	Chaperone
CH46_3416	COG3539	Fimbrial protein
CH46_3419	COG0793	Belongs to the peptidase S41A family
CH46_342	COG0586	Pfam SNARE associated Golgi protein
CH46_3421	COG1956	GAF domain-containing protein
CH46_3422	COG2995	paraquat-inducible protein a
CH46_3423	COG3008	intermembrane lipid transfer
CH46_3427	COG3121	Chaperone
CH46_3439	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH46_3442	COG5295	Hep Hag repeat protein
CH46_3444	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH46_3445	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH46_3446	COG0745	RESPONSE REGULATOR receiver
CH46_3448	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH46_345	COG4575	ribosome binding
CH46_3451	COG0840	transmembrane signaling receptor activity
CH46_3455	COG2964	Protein conserved in bacteria
CH46_3457	COG0251	oxidation-reduction process
CH46_3458	COG2271	Major facilitator Superfamily
CH46_3459	COG0835	chemotaxis
CH46_346	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH46_3460	COG2198	Histidine kinase
CH46_3460	COG0643	Histidine kinase
CH46_3461	COG1360	Flagellar Motor Protein
CH46_3466	COG1285	pathogenesis
CH46_3467	COG0840	transmembrane signaling receptor activity
CH46_3468	COG0840	transmembrane signaling receptor activity
CH46_3470	COG1278	Cold shock
CH46_3472	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_3472	COG0604	alcohol dehydrogenase
CH46_3472	COG3321	synthase
CH46_3474	COG1522	sequence-specific DNA binding
CH46_3479	COG1733	regulation of RNA biosynthetic process
CH46_348	COG2259	Doxx family
CH46_3480	COG0702	epimerase
CH46_3481	COG0840	transmembrane signaling receptor activity
CH46_3484	COG0538	isocitrate dehydrogenase activity
CH46_3485	COG1187	pseudouridine synthase activity
CH46_3489	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH46_349	COG0435	Glutathione S-transferase
CH46_3491	COG0745	RESPONSE REGULATOR receiver
CH46_3493	COG2850	peptidyl-arginine hydroxylation
CH46_3495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH46_3497	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH46_3499	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH46_3500	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH46_3501	COG3134	Outer membrane lipoprotein
CH46_3504	COG3328	transposase activity
CH46_3507	COG1252	NADH dehydrogenase
CH46_3509	COG1472	Belongs to the glycosyl hydrolase 3 family
CH46_3512	COG5633	Lipoprotein
CH46_3513	COG0537	adenosine 5'-monophosphoramidase activity
CH46_3514	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH46_3515	COG1943	Transposase
CH46_3516	COG1263	PTS System
CH46_3516	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH46_3517	COG0084	hydrolase, TatD family'
CH46_3518	COG0470	DNA polymerase III
CH46_352	COG0494	nUDIX hydrolase
CH46_3520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH46_3521	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH46_3522	COG1943	Transposase
CH46_3523	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH46_3525	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_3529	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH46_3530	COG1399	metal-binding, possibly nucleic acid-binding protein
CH46_3532	COG1943	Transposase
CH46_3533	COG0564	pseudouridine synthase activity
CH46_3534	COG1530	ribonuclease E activity
CH46_3535	COG3328	transposase activity
CH46_3536	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH46_3539	COG3328	transposase activity
CH46_3541	COG2223	nitrite transmembrane transporter activity
CH46_3546	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH46_3551	COG3122	Protein conserved in bacteria
CH46_3555	COG0534	Mate efflux family protein
CH46_3559	COG4948	Mandelate Racemase Muconate Lactonizing
CH46_3561	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_3562	COG3011	Protein conserved in bacteria
CH46_3563	COG2271	Major facilitator Superfamily
CH46_3564	COG3328	transposase activity
CH46_3565	COG1470	cell adhesion involved in biofilm formation
CH46_3565	COG1388	LysM domain
CH46_3568	COG2925	Exonuclease
CH46_3569	COG0531	amino acid
CH46_357	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH46_3571	COG0371	Dehydrogenase
CH46_3572	COG1129	ABC transporter
CH46_3573	COG1129	ABC transporter
CH46_3574	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_3576	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH46_3578	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CH46_358	COG0849	cell division
CH46_3580	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH46_3580	COG0131	Imidazoleglycerol-phosphate dehydratase
CH46_3581	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CH46_3584	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH46_3584	COG0140	phosphoribosyl-ATP diphosphatase activity
CH46_3586	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH46_3587	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH46_359	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH46_3590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH46_3591	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH46_3592	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH46_3593	COG1120	ATPase activity
CH46_3596	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CH46_3597	COG0076	glutamate decarboxylase activity
CH46_3598	COG4114	ferric iron reductase
CH46_3599	COG1253	flavin adenine dinucleotide binding
CH46_3600	COG2982	Protein involved in outer membrane biogenesis
CH46_3603	COG0489	protein tyrosine kinase activity
CH46_3605	COG1943	Transposase
CH46_3611	COG2814	Major facilitator Superfamily
CH46_3613	COG1346	cytolysis
CH46_3616	COG2949	membrane
CH46_3617	COG4211	Belongs to the binding-protein-dependent transport system permease family
CH46_3620	COG2311	Membrane
CH46_3622	COG0477	Major facilitator Superfamily
CH46_3623	COG0583	DNA-binding transcription factor activity
CH46_3629	COG1136	(ABC) transporter
CH46_363	COG0772	Belongs to the SEDS family
CH46_3631	COG0303	'Molybdopterin
CH46_3633	COG3328	transposase activity
CH46_3635	COG0488	(ABC) transporter
CH46_366	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH46_3662	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH46_3663	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CH46_3665	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_3666	COG1024	Enoyl-CoA hydratase
CH46_3668	COG3425	synthase
CH46_3669	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_367	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH46_3670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH46_3671	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH46_3673	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_368	COG0768	penicillin binding
CH46_3680	COG2920	part of a sulfur-relay system
CH46_3684	COG1832	CoA-binding protein
CH46_3685	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CH46_3687	COG0210	DNA helicase
CH46_3688	COG3304	Inner membrane component domain
CH46_3689	COG1289	transmembrane transporter activity
CH46_369	COG3116	cell division
CH46_3690	COG3070	regulator of competence-specific genes
CH46_3692	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH46_3692	COG2885	chlorophyll binding
CH46_3693	COG1943	Transposase
CH46_3695	COG1067	ATP-dependent peptidase activity
CH46_3698	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH46_37	COG2944	sequence-specific DNA binding
CH46_3703	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH46_3704	COG1943	Transposase
CH46_3705	COG3009	Protein conserved in bacteria
CH46_3706	COG3008	intermembrane lipid transfer
CH46_3706	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH46_3707	COG2995	paraquat-inducible protein a
CH46_3708	COG0488	(ABC) transporter
CH46_3710	COG3217	Mosc domain protein beta barrel domain protein
CH46_3710	COG0633	Ferredoxin
CH46_3713	COG0308	aminopeptidase N
CH46_3717	COG1448	Aminotransferase
CH46_3718	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH46_3719	COG3108	Peptidase M15
CH46_3720	COG2989	Protein conserved in bacteria
CH46_3721	COG1943	Transposase
CH46_3723	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CH46_3724	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH46_3725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH46_3726	COG3173	Aminoglycoside phosphotransferase
CH46_3728	COG2835	tetraacyldisaccharide 4'-kinase activity
CH46_3729	COG1278	Cold shock
CH46_373	COG1609	Transcriptional regulator
CH46_3730	COG5383	Protein conserved in bacteria
CH46_3733	COG2333	competence protein COMEC
CH46_3733	COG0658	competence protein
CH46_3736	COG0539	negative regulation of cytoplasmic translation
CH46_374	COG1943	Transposase
CH46_3741	COG5295	Hep Hag repeat protein
CH46_3741	COG5295	Hep Hag repeat protein
CH46_3742	COG0252	asparaginase activity
CH46_3743	COG1944	ATP diphosphatase activity
CH46_3744	COG2116	formate transmembrane transporter activity
CH46_3745	COG1882	Formate acetyltransferase
CH46_3747	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH46_3748	COG2814	Major facilitator Superfamily
CH46_3750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH46_3753	COG1674	ftsk spoiiie
CH46_3753	COG3107	peptidoglycan biosynthetic process
CH46_3755	COG0492	ferredoxin-NADP+ reductase activity
CH46_3757	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH46_3759	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH46_376	COG0028	Belongs to the TPP enzyme family
CH46_3760	COG1943	Transposase
CH46_3761	COG0542	response to heat
CH46_3763	COG1278	Cold shock
CH46_3765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH46_3766	COG2990	Protein conserved in bacteria
CH46_3767	COG3593	DNA synthesis involved in DNA repair
CH46_3768	COG2431	L-lysine efflux transmembrane transporter activity
CH46_377	COG1022	Amp-dependent synthetase and ligase
CH46_3770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH46_3771	COG0028	Belongs to the TPP enzyme family
CH46_3772	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH46_3773	COG0702	epimerase
CH46_3774	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH46_3776	COG1605	Chorismate mutase
CH46_3777	COG1126	abc transporter atp-binding protein
CH46_3778	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH46_3779	COG4215	(ABC) transporter
CH46_3780	COG4160	amino acid transport
CH46_3784	COG1120	ATPase activity
CH46_3785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH46_3790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH46_3793	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH46_3796	COG1177	transmembrane transport
CH46_3797	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH46_3798	COG3842	ATPase activity
CH46_3799	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH46_380	COG1943	Transposase
CH46_3802	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH46_3803	COG2985	domain, Protein
CH46_3803	COG0569	domain protein
CH46_3805	COG0671	phosphoesterase, PA-phosphatase related
CH46_3806	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH46_3807	COG1349	DNA-binding transcription factor activity
CH46_3808	COG0814	amino acid
CH46_3809	COG1686	Belongs to the peptidase S11 family
CH46_3810	COG2011	ABC-type metal ion transport system permease component
CH46_3815	COG0625	glutathione transferase activity
CH46_3816	COG4771	TonB-dependent receptor
CH46_3818	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH46_382	COG0473	3-isopropylmalate dehydrogenase activity
CH46_3820	COG0833	amino acid
CH46_3822	COG0583	DNA-binding transcription factor activity
CH46_3823	COG2855	membrane
CH46_3825	COG3188	usher protein
CH46_3826	COG3121	Chaperone
CH46_3829	COG3710	Transcriptional regulator
CH46_3830	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH46_3830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH46_3830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH46_3831	COG1105	Belongs to the carbohydrate kinase PfkB family
CH46_3833	COG0494	nUDIX hydrolase
CH46_3834	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_3835	COG1129	ABC transporter
CH46_3837	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH46_3842	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_3846	COG1312	Catalyzes the dehydration of D-mannonate
CH46_3847	COG0246	Mannitol dehydrogenase
CH46_3848	COG2186	Transcriptional regulator
CH46_385	COG2814	Major facilitator Superfamily
CH46_3850	COG0523	cobalamin synthesis protein
CH46_3851	COG0671	phosphoesterase, PA-phosphatase related
CH46_3852	COG0791	NLP P60 protein
CH46_3854	COG2200	EAL domain
CH46_3855	COG4166	transmembrane transport
CH46_3856	COG4174	ABC transporter (Permease)
CH46_3857	COG4239	(ABC) transporter, permease
CH46_3858	COG4172	Belongs to the ABC transporter superfamily
CH46_3860	COG2814	Major facilitator Superfamily
CH46_3861	COG1187	pseudouridine synthase activity
CH46_3862	COG1061	Type III restriction enzyme res subunit
CH46_3864	COG1943	Transposase
CH46_3866	COG3082	Protein of unknown function (DUF1414)
CH46_3867	COG3083	sulfuric ester hydrolase activity
CH46_3870	COG3157	Type VI secretion system effector, Hcp
CH46_3874	COG2723	6-phospho-beta-galactosidase activity
CH46_3876	COG1737	Transcriptional regulator
CH46_388	COG2814	Major facilitator Superfamily
CH46_3880	COG3299	homolog of phage Mu protein gp47
CH46_3888	COG4386	tail sheath protein
CH46_3892	COG3622	Belongs to the hyi family
CH46_3893	COG1349	DNA-binding transcription factor activity
CH46_3894	COG0235	Class ii aldolase
CH46_3895	COG3395	kinase activity
CH46_3904	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH46_3907	COG1943	Transposase
CH46_3908	COG1943	Transposase
CH46_3909	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH46_391	COG4143	(ABC) transporter
CH46_3911	COG2223	nitrite transmembrane transporter activity
CH46_3912	COG0642	Histidine kinase
CH46_3912	COG2198	Histidine kinase
CH46_3913	COG2198	Histidine kinase
CH46_3913	COG0642	Histidine kinase
CH46_3915	COG2205	protein histidine kinase activity
CH46_3915	COG0784	Response regulator, receiver
CH46_392	COG1178	ABC-type Fe3 transport system permease component
CH46_3920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH46_3923	COG0814	amino acid
CH46_3928	COG0697	spore germination
CH46_3930	COG1982	Orn Lys Arg decarboxylase major
CH46_3931	COG0531	amino acid
CH46_3932	COG1174	glycine betaine transport
CH46_3933	COG1125	glycine betaine transport
CH46_3934	COG1174	glycine betaine transport
CH46_3937	COG2897	thiosulfate sulfurtransferase activity
CH46_394	COG0586	Pfam SNARE associated Golgi protein
CH46_3940	COG0410	ABC transporter
CH46_3941	COG1122	ATPase activity
CH46_3945	COG4807	Protein conserved in bacteria
CH46_3948	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CH46_395	COG0417	DNA replication proofreading
CH46_3950	COG2261	transglycosylase associated protein
CH46_3952	COG1403	HNH endonuclease
CH46_3954	COG0277	FAD linked oxidase domain protein
CH46_3955	COG1686	Belongs to the peptidase S11 family
CH46_3957	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH46_3959	COG1943	Transposase
CH46_3960	COG2211	Major facilitator Superfamily
CH46_3961	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CH46_3963	COG0583	DNA-binding transcription factor activity
CH46_3964	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CH46_3968	COG1943	Transposase
CH46_3969	COG0670	Belongs to the BI1 family
CH46_3970	COG0314	molybdopterin synthase activity
CH46_3971	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH46_3973	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH46_3975	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH46_3976	COG4628	conserved protein (DUF2132)
CH46_3977	COG0556	nucleotide-excision repair
CH46_3979	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH46_3980	COG2226	methyltransferase
CH46_3985	COG0561	phosphatase activity
CH46_3987	COG4149	molybdate abc transporter
CH46_3988	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH46_399	COG3047	cAMP biosynthetic process
CH46_399	COG2885	chlorophyll binding
CH46_3990	COG2005	Transcriptional regulator
CH46_3990	COG3585	molybdate ion transport
CH46_3991	COG1119	ATPase activity
CH46_3994	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH46_3995	COG1085	galactose-1-phosphate uridylyltransferase
CH46_3998	COG2017	converts alpha-aldose to the beta-anomer
CH46_4	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH46_4003	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH46_4005	COG1230	cation diffusion facilitator family transporter
CH46_4010	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH46_4011	COG2885	chlorophyll binding
CH46_4013	COG3064	Membrane
CH46_4013	COG3064	Membrane
CH46_4014	COG0848	biopolymer transport protein
CH46_4015	COG0811	peptide transport
CH46_4016	COG0824	Thioesterase
CH46_4017	COG3790	cyd operon protein YbgE
CH46_4018	COG4890	Cyd operon protein YbgT
CH46_4019	COG1294	oxidase, subunit
CH46_4020	COG1271	oxidase subunit
CH46_4021	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH46_4023	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH46_4024	COG0567	Dehydrogenase, E1 component
CH46_4026	COG1053	succinate dehydrogenase
CH46_4027	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH46_4028	COG2009	succinate dehydrogenase
CH46_4031	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH46_4032	COG0497	DNA recombination
CH46_4033	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH46_4035	COG2867	negative regulation of translational initiation
CH46_4037	COG1943	Transposase
CH46_4038	COG0582	viral genome integration into host DNA
CH46_4048	COG3657	addiction module killer protein
CH46_4054	COG1953	Uracil, thiamine, allantoin
CH46_4056	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH46_4058	COG2226	methyltransferase
CH46_4060	COG0741	lytic transglycosylase activity
CH46_4060	COG1388	LysM domain
CH46_4063	COG0656	L-ascorbic acid biosynthetic process
CH46_4069	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH46_407	COG3501	Rhs element vgr protein
CH46_4071	COG2011	ABC-type metal ion transport system permease component
CH46_4072	COG1464	Belongs to the NlpA lipoprotein family
CH46_4074	COG1720	tRNA m6t6A37 methyltransferase activity
CH46_4076	COG3015	lipoprotein NlpE involved in copper resistance
CH46_4078	COG4681	YaeQ
CH46_4080	COG4568	rho-dependent transcription termination
CH46_4082	COG0037	tRNA processing
CH46_4083	COG0346	lactoylglutathione lyase activity
CH46_4085	COG0587	DNA-directed DNA polymerase activity
CH46_4087	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH46_4091	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH46_4093	COG0750	zinc metalloprotease
CH46_4094	COG0575	Belongs to the CDS family
CH46_4095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CH46_4101	COG0024	Methionine aminopeptidase
CH46_4106	COG0564	pseudouridine synthase activity
CH46_4107	COG3098	single-species biofilm formation
CH46_4108	COG1943	Transposase
CH46_4111	COG1611	Belongs to the LOG family
CH46_4112	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH46_4114	COG2363	Small membrane protein
CH46_4115	COG0583	DNA-binding transcription factor activity
CH46_4117	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH46_4118	COG2166	iron-sulfur cluster assembly
CH46_4119	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH46_4120	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH46_4123	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH46_4125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH46_4126	COG1074	ATP-dependent DNA helicase activity
CH46_4128	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH46_4135	COG4771	TonB-dependent receptor
CH46_4136	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH46_4137	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CH46_4145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH46_4147	COG3300	MHYT domain
CH46_4147	COG5001	Diguanylate cyclase
CH46_4148	COG2801	Transposase and inactivated derivatives
CH46_4150	COG2211	Major facilitator Superfamily
CH46_4160	COG3916	Acyl-homoserine-lactone synthase
CH46_4161	COG2771	luxR family
CH46_417	COG0564	pseudouridine synthase activity
CH46_418	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH46_4182	COG1662	PFAM IS1 transposase
CH46_4186	COG1982	Orn Lys Arg decarboxylase major
CH46_4187	COG1879	ABC-type sugar transport system periplasmic component
CH46_4188	COG1129	ABC transporter
CH46_4189	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_4190	COG4774	siderophore transport
CH46_4194	COG1194	a g-specific adenine glycosylase
CH46_4196	COG3171	Protein conserved in bacteria
CH46_4197	COG2066	Belongs to the glutaminase family
CH46_420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH46_4200	COG3064	Membrane
CH46_4200	COG1073	alpha beta
CH46_4200	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CH46_4201	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH46_4202	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH46_4204	COG0762	integral membrane protein
CH46_4205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH46_4206	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH46_4207	COG2805	Type II/IV secretion system protein
CH46_4209	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH46_421	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CH46_4212	COG0189	ligase activity
CH46_4213	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH46_4214	COG2356	endonuclease I
CH46_4215	COG3091	SprT-like family
CH46_4218	COG1166	arginine decarboxylase activity
CH46_4220	COG0501	Belongs to the peptidase M48B family
CH46_4221	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH46_4222	COG1943	Transposase
CH46_4227	COG0191	fructose-bisphosphate aldolase activity
CH46_4238	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CH46_4240	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH46_4240	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH46_4247	COG3941	tape measure
CH46_426	COG1943	Transposase
CH46_4265	COG1475	DNA binding
CH46_4266	COG1475	DNA binding
CH46_4267	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH46_427	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH46_4276	COG1943	Transposase
CH46_4282	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH46_429	COG2966	Psort location CytoplasmicMembrane, score
CH46_4292	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH46_4294	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH46_430	COG1280	lysine exporter protein (LysE YggA)
CH46_4303	COG1475	DNA binding
CH46_431	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH46_4318	COG1943	Transposase
CH46_432	COG0505	Belongs to the CarA family
CH46_4320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH46_4322	COG3344	reverse transcriptase
CH46_4324	COG3328	transposase activity
CH46_4334	COG4886	Leucine-rich repeat (LRR) protein
CH46_4339	COG0457	Tetratricopeptide repeat
CH46_434	COG1943	Transposase
CH46_4343	COG4789	Type iii secretion
CH46_4352	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH46_4353	COG4790	Type iii secretion
CH46_4354	COG4794	Type iii secretion
CH46_4355	COG4791	protein targeting
CH46_4356	COG4792	protein secretion
CH46_4358	COG2207	Transcriptional regulator
CH46_436	COG1047	Peptidyl-prolyl cis-trans
CH46_4367	COG4669	(LipO)protein
CH46_4369	COG1317	bacterial-type flagellum organization
CH46_4370	COG5599	Phosphatase
CH46_4371	COG2963	transposase activity
CH46_4372	COG2801	Transposase and inactivated derivatives
CH46_4375	COG2801	Transposase and inactivated derivatives
CH46_4377	COG0515	serine threonine protein kinase
CH46_439	COG0196	riboflavin kinase activity
CH46_4395	COG2801	Transposase and inactivated derivatives
CH46_4400	COG2801	Transposase and inactivated derivatives
CH46_4407	COG2801	Transposase and inactivated derivatives
CH46_4409	COG5599	Phosphatase
CH46_441	COG0583	DNA-binding transcription factor activity
CH46_4411	COG3609	addiction module antidote protein, CC2985 family
CH46_4413	COG1475	DNA binding
CH46_4414	COG1192	Involved in chromosome partitioning
CH46_4416	COG2801	Transposase and inactivated derivatives
CH46_4420	COG3177	Filamentation induced by cAMP protein fic
CH46_4428	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CH46_445	COG1584	GPR1 FUN34 yaaH family protein
CH46_448	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH46_456	COG0745	RESPONSE REGULATOR receiver
CH46_457	COG3045	CreA protein
CH46_460	COG2207	Transcriptional regulator
CH46_460	COG3708	Transcriptional regulator
CH46_461	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH46_463	COG0741	lytic transglycosylase activity
CH46_466	COG2199	diguanylate cyclase activity
CH46_467	COG2885	chlorophyll binding
CH46_468	COG0488	(ABC) transporter
CH46_469	COG0488	(ABC) transporter
CH46_473	COG0560	Phosphoserine phosphatase
CH46_474	COG3726	membrane protein affecting hemolysin expression
CH46_479	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH46_480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH46_481	COG0084	hydrolase, TatD family'
CH46_482	COG4667	esterase of the alpha-beta hydrolase superfamily
CH46_484	COG2823	Periplasmic or secreted lipoprotein
CH46_486	COG0456	acetyltransferase
CH46_487	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH46_491	COG3706	GGDEF domain
CH46_494	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH46_495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH46_498	COG0859	PFAM glycosyl transferase family 9
CH46_5	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH46_500	COG2390	Transcriptional regulator
CH46_501	COG2390	Transcriptional regulator
CH46_509	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH46_509	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH46_509	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH46_510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH46_511	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH46_512	COG2207	Transcriptional regulator
CH46_513	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH46_515	COG4269	membrane
CH46_525	COG2963	transposase activity
CH46_527	COG1401	restriction endodeoxyribonuclease activity
CH46_531	COG3650	response to hydrogen peroxide
CH46_532	COG1960	acyl-CoA dehydrogenase activity
CH46_533	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH46_534	COG0557	exoribonuclease II activity
CH46_537	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH46_538	COG0330	HflC and HflK could
CH46_539	COG0330	HflC and HflK could
CH46_54	COG1695	Transcriptional regulator
CH46_540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH46_544	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH46_545	COG0802	atpase or kinase
CH46_546	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH46_546	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH46_547	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH46_55	COG0791	NLP P60 protein
CH46_550	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH46_553	COG1511	domain protein
CH46_553	COG3264	Mechanosensitive ion channel
CH46_555	COG1053	succinate dehydrogenase
CH46_556	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH46_558	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH46_559	COG1943	Transposase
CH46_560	COG2076	Multidrug Resistance protein
CH46_568	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH46_57	COG1879	ABC-type sugar transport system periplasmic component
CH46_571	COG3383	formate dehydrogenase (NAD+) activity
CH46_572	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH46_573	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH46_573	COG0493	'glutamate synthase
CH46_574	COG1309	transcriptional regulator
CH46_58	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH46_588	COG1454	alcohol dehydrogenase
CH46_59	COG1129	ABC transporter
CH46_590	COG0629	single-stranded DNA binding
CH46_591	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH46_592	COG2315	Protein conserved in bacteria
CH46_593	COG1448	Aminotransferase
CH46_594	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH46_595	COG0305	Participates in initiation and elongation during chromosome replication
CH46_598	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH46_599	COG0735	belongs to the Fur family
CH46_601	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH46_609	COG3121	Chaperone
CH46_61	COG2182	Extracellular solute-binding protein
CH46_62	COG1175	transmembrane transport
CH46_621	COG1358	cellular component organization or biogenesis
CH46_626	COG3721	Heme iron utilization protein
CH46_627	COG0702	epimerase
CH46_629	COG4771	TonB-dependent receptor
CH46_63	COG3833	ABC-type maltose transport systems, permease component
CH46_630	COG3720	iron ion transport
CH46_631	COG4558	Periplasmic binding protein
CH46_632	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH46_634	COG0626	cystathionine gamma-synthase activity
CH46_635	COG0814	amino acid
CH46_636	COG0583	DNA-binding transcription factor activity
CH46_637	COG0425	Belongs to the sulfur carrier protein TusA family
CH46_638	COG2391	methyltransferase activity
CH46_64	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CH46_65	COG1874	Beta-galactosidase
CH46_66	COG1263	PTS System
CH46_66	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH46_660	COG1301	dicarboxylic acid transport
CH46_662	COG3162	membrane
CH46_669	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH46_672	COG0551	DNA topoisomerase type I activity
CH46_674	COG0758	DNA mediated transformation
CH46_678	COG0569	domain protein
CH46_680	COG3036	rescue of stalled ribosome
CH46_681	COG0789	Transcriptional regulator
CH46_684	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH46_687	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH46_688	COG0201	protein transport
CH46_690	COG1841	ribosomal large subunit assembly
CH46_698	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH46_699	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH46_70	COG2271	Major facilitator Superfamily
CH46_701	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH46_702	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CH46_704	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH46_709	COG0051	transcription antitermination factor activity, RNA binding
CH46_712	COG1943	Transposase
CH46_715	COG0049	tRNA binding
CH46_716	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH46_720	COG2964	Protein conserved in bacteria
CH46_721	COG0545	Peptidyl-prolyl cis-trans isomerase
CH46_723	COG1047	Peptidyl-prolyl cis-trans
CH46_724	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH46_727	COG0488	(ABC) transporter
CH46_728	COG0488	(ABC) transporter
CH46_729	COG1216	Glycosyl transferase, family 2
CH46_731	COG2175	clavaminate synthase activity
CH46_732	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH46_734	COG4521	taurine ABC transporter
CH46_736	COG0429	hydrolase of the alpha beta-hydrolase fold
CH46_738	COG3954	Phosphoribulokinase
CH46_74	COG0191	fructose-bisphosphate aldolase activity
CH46_740	COG1765	OsmC-like protein
CH46_742	COG1289	transmembrane transporter activity
CH46_745	COG0433	COG0433 Predicted ATPase
CH46_746	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH46_747	COG1486	melibiose metabolic process
CH46_750	COG1486	melibiose metabolic process
CH46_754	COG0402	S-adenosylhomocysteine deaminase activity
CH46_755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH46_756	COG2146	nitrite reductase [NAD(P)H] activity
CH46_759	COG0180	Tryptophanyl-tRNA synthetase
CH46_76	COG3119	arylsulfatase activity
CH46_760	COG0546	phosphoglycolate phosphatase activity
CH46_761	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH46_766	COG4796	Type ii and iii secretion system protein
CH46_77	COG0641	radical SAM
CH46_771	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH46_772	COG0494	nUDIX hydrolase
CH46_775	COG1011	Hydrolase
CH46_776	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH46_780	COG0745	RESPONSE REGULATOR receiver
CH46_781	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH46_782	COG2183	response to ionizing radiation
CH46_783	COG1918	ferrous iron import across plasma membrane
CH46_79	COG1028	Short-chain dehydrogenase reductase Sdr
CH46_790	COG1640	4-alpha-glucanotransferase
CH46_791	COG0058	SHG alpha-glucan phosphorylase activity
CH46_792	COG0058	SHG alpha-glucan phosphorylase activity
CH46_794	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH46_796	COG1349	DNA-binding transcription factor activity
CH46_798	COG2801	Transposase and inactivated derivatives
CH46_8	COG0006	proline dipeptidase activity
CH46_800	COG0460	homoserine dehydrogenase
CH46_800	COG0527	aspartate kinase activity
CH46_801	COG0626	cystathionine gamma-synthase activity
CH46_802	COG0626	cystathionine gamma-synthase activity
CH46_804	COG4682	membrane
CH46_806	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH46_808	COG1609	Transcriptional regulator
CH46_809	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH46_81	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH46_812	COG1575	Belongs to the MenA family. Type 1 subfamily
CH46_82	COG3716	PTS system mannose fructose sorbose family IID component
CH46_821	COG1943	Transposase
CH46_823	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH46_824	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH46_825	COG1494	fructose-1,6-bisphosphatase
CH46_827	COG3152	Membrane
CH46_83	COG3715	PTS system
CH46_830	COG0583	DNA-binding transcription factor activity
CH46_831	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CH46_832	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CH46_833	COG0471	metal ion transport
CH46_835	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH46_84	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH46_840	COG3678	ATP-independent chaperone mediated protein folding
CH46_841	COG0745	RESPONSE REGULATOR receiver
CH46_842	COG2205	protein histidine kinase activity
CH46_843	COG2169	Transcriptional regulator
CH46_843	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH46_844	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH46_845	COG1045	serine acetyltransferase
CH46_848	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH46_849	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH46_85	COG2222	sugar isomerase
CH46_851	COG4942	peptidase
CH46_852	COG2861	carbohydrate metabolic process
CH46_853	COG2861	carbohydrate metabolic process
CH46_855	COG0156	8-amino-7-oxononanoate synthase activity
CH46_857	COG0859	PFAM glycosyl transferase family 9
CH46_858	COG0859	PFAM glycosyl transferase family 9
CH46_859	COG1519	Transferase
CH46_863	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH46_866	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH46_87	COG1349	DNA-binding transcription factor activity
CH46_871	COG1561	YicC-like family, N-terminal region
CH46_872	COG2860	membrane
CH46_873	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH46_876	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH46_877	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH46_878	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH46_879	COG0786	glutamate:sodium symporter activity
CH46_88	COG3119	arylsulfatase activity
CH46_880	COG2233	PERMEase
CH46_881	COG2982	Protein involved in outer membrane biogenesis
CH46_882	COG0456	acetyltransferase
CH46_886	COG1295	ribonuclease BN
CH46_887	COG1011	Hydrolase
CH46_889	COG0174	glutamine synthetase
CH46_89	COG1943	Transposase
CH46_890	COG3852	Histidine kinase
CH46_892	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH46_895	COG1943	Transposase
CH46_896	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH46_896	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH46_897	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH46_898	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH46_899	COG3084	Protein conserved in bacteria
CH46_9	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH46_901	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH46_902	COG3328	transposase activity
CH46_907	COG2186	Transcriptional regulator
CH46_909	COG0477	Major facilitator Superfamily
CH46_910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH46_916	COG1522	sequence-specific DNA binding
CH46_917	COG0716	FMN binding
CH46_920	COG3312	ion transport
CH46_930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CH46_931	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH46_932	COG0573	inorganic phosphate transmembrane transporter activity
CH46_933	COG0581	inorganic phosphate transmembrane transporter activity
CH46_935	COG0704	Plays a role in the regulation of phosphate uptake
CH46_937	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH46_938	COG0765	amino acid transport
CH46_939	COG0765	amino acid transport
CH46_940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH46_941	COG2252	PERMEase
CH46_946	COG0706	membrane insertase activity
CH46_949	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH46_952	COG0592	DNA-directed DNA polymerase activity
CH46_953	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH46_954	COG0187	DNA topoisomerase II activity
CH46_955	COG0561	phosphatase activity
CH46_958	COG2801	Transposase and inactivated derivatives
CH46_96	COG0288	reversible hydration of carbon dioxide
CH46_961	COG2423	ornithine cyclodeaminase activity
CH46_962	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH46_963	COG0823	Involved in the tonB-independent uptake of proteins
CH46_964	COG0823	Involved in the tonB-independent uptake of proteins
CH46_965	COG5645	(Lipo)protein
CH46_969	COG3977	Valine--pyruvate aminotransferase
CH46_971	COG0366	Alpha amylase catalytic
CH46_974	COG2885	chlorophyll binding
CH46_976	COG2818	Glycosylase
CH46_981	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH46_981	COG2213	PTS system mannitol-specific
CH46_983	COG3722	fumarate hydratase activity
CH46_990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH46_992	COG0243	molybdopterin cofactor binding
CH46_992	COG3383	formate dehydrogenase (NAD+) activity
CH46_993	COG3383	formate dehydrogenase (NAD+) activity
CH46_993	COG0243	molybdopterin cofactor binding
CH46_994	COG0437	4 iron, 4 sulfur cluster binding
CH46_995	COG2864	formate dehydrogenase