locus-tag	class	description
ISU57_00010	COG0592	DNA-directed DNA polymerase activity
ISU57_00025	COG0187	DNA topoisomerase II activity
ISU57_00030	COG0561	phosphatase activity
ISU57_00040	COG2423	ornithine cyclodeaminase activity
ISU57_00045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISU57_00055	COG5645	(Lipo)protein
ISU57_00075	COG3977	Valine--pyruvate aminotransferase
ISU57_00085	COG0366	Alpha amylase catalytic
ISU57_00100	COG2885	chlorophyll binding
ISU57_00110	COG2818	Glycosylase
ISU57_00135	COG2213	PTS system mannitol-specific
ISU57_00135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_00145	COG3722	fumarate hydratase activity
ISU57_00170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISU57_00185	COG0437	4 iron, 4 sulfur cluster binding
ISU57_00190	COG2864	formate dehydrogenase
ISU57_00205	COG3276	selenocysteine insertion sequence binding
ISU57_00250	COG3274	enterobacterial common antigen metabolic process
ISU57_00275	COG1070	Carbohydrate kinase
ISU57_00285	COG4213	ABC transporter substrate-binding protein
ISU57_00295	COG4214	carbohydrate transport
ISU57_00300	COG2207	Transcriptional regulator
ISU57_00300	COG1609	Transcriptional regulator
ISU57_00310	COG0582	viral genome integration into host DNA
ISU57_00355	COG4604	ABC transporter, ATP-binding protein
ISU57_00360	COG4605	iron ion homeostasis
ISU57_00370	COG4607	ABC-type enterochelin transport system periplasmic component
ISU57_00400	COG2986	histidine ammonia-lyase
ISU57_00415	COG2194	sulfuric ester hydrolase activity
ISU57_00420	COG2197	response regulator
ISU57_00440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISU57_00455	COG0551	DNA topoisomerase type I activity
ISU57_00465	COG0758	DNA mediated transformation
ISU57_00495	COG3036	rescue of stalled ribosome
ISU57_00500	COG0789	Transcriptional regulator
ISU57_00515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISU57_00530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU57_00535	COG0201	protein transport
ISU57_00545	COG1841	ribosomal large subunit assembly
ISU57_00585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ISU57_00590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISU57_00600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISU57_00605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISU57_00615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISU57_00625	COG0089	rRNA binding
ISU57_00640	COG0051	transcription antitermination factor activity, RNA binding
ISU57_00670	COG0049	tRNA binding
ISU57_00675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ISU57_00695	COG2964	Protein conserved in bacteria
ISU57_00700	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU57_00710	COG1047	Peptidyl-prolyl cis-trans
ISU57_00715	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISU57_00735	COG1216	Glycosyl transferase, family 2
ISU57_00745	COG2175	clavaminate synthase activity
ISU57_00750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU57_00760	COG4521	taurine ABC transporter
ISU57_00770	COG0429	hydrolase of the alpha beta-hydrolase fold
ISU57_00780	COG3954	Phosphoribulokinase
ISU57_00790	COG1765	OsmC-like protein
ISU57_00800	COG1289	transmembrane transporter activity
ISU57_00815	COG0433	COG0433 Predicted ATPase
ISU57_00820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU57_00825	COG1486	melibiose metabolic process
ISU57_00845	COG0402	S-adenosylhomocysteine deaminase activity
ISU57_00850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISU57_00870	COG0180	Tryptophanyl-tRNA synthetase
ISU57_00875	COG0546	phosphoglycolate phosphatase activity
ISU57_00880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISU57_00905	COG4796	Type ii and iii secretion system protein
ISU57_00930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISU57_00935	COG0494	nUDIX hydrolase
ISU57_00945	COG1011	Hydrolase
ISU57_00950	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISU57_00975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU57_00980	COG2183	response to ionizing radiation
ISU57_00985	COG1918	ferrous iron import across plasma membrane
ISU57_01020	COG1640	4-alpha-glucanotransferase
ISU57_01025	COG0058	SHG alpha-glucan phosphorylase activity
ISU57_01030	COG0058	SHG alpha-glucan phosphorylase activity
ISU57_01050	COG1349	DNA-binding transcription factor activity
ISU57_01075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU57_01080	COG0058	SHG alpha-glucan phosphorylase activity
ISU57_01105	COG3275	phosphorelay sensor kinase activity
ISU57_01140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU57_01145	COG2095	MarC family integral membrane protein
ISU57_01165	COG3265	gluconokinase activity
ISU57_01170	COG2610	gluconate transmembrane transporter activity
ISU57_01175	COG1609	Transcriptional regulator
ISU57_01180	COG1741	Belongs to the pirin family
ISU57_01200	COG0191	fructose-bisphosphate aldolase activity
ISU57_01215	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_01230	COG2081	HI0933 family
ISU57_01235	COG0306	phosphate transporter
ISU57_01250	COG0589	response to stress
ISU57_01270	COG0339	signal peptide processing
ISU57_01275	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISU57_01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU57_01285	COG3835	regulator
ISU57_01295	COG2610	gluconate transmembrane transporter activity
ISU57_01300	COG1929	Belongs to the glycerate kinase type-1 family
ISU57_01325	COG1295	ribonuclease BN
ISU57_01330	COG2134	cdp-diacylglycerol pyrophosphatase
ISU57_01335	COG2982	Protein involved in outer membrane biogenesis
ISU57_01340	COG2200	EAL domain
ISU57_01345	COG1942	4-Oxalocrotonate Tautomerase
ISU57_01350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU57_01355	COG0612	Peptidase, M16
ISU57_01375	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU57_01380	COG2199	diguanylate cyclase activity
ISU57_01380	COG2200	EAL domain
ISU57_01385	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISU57_01395	COG4608	Belongs to the ABC transporter superfamily
ISU57_01400	COG0444	Belongs to the ABC transporter superfamily
ISU57_01405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU57_01410	COG0601	transmembrane transport
ISU57_01415	COG0747	negative chemotaxis
ISU57_01420	COG2831	hemolysin activation secretion protein
ISU57_01435	COG2271	Major facilitator Superfamily
ISU57_01490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISU57_01495	COG2224	Isocitrate lyase
ISU57_01525	COG0527	aspartate kinase activity
ISU57_01540	COG3833	ABC-type maltose transport systems, permease component
ISU57_01545	COG1175	transmembrane transport
ISU57_01625	COG2885	chlorophyll binding
ISU57_01630	COG2199	diguanylate cyclase activity
ISU57_01645	COG0741	lytic transglycosylase activity
ISU57_01650	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ISU57_01665	COG2207	Transcriptional regulator
ISU57_01665	COG3708	Transcriptional regulator
ISU57_01670	COG3045	CreA protein
ISU57_01675	COG0745	RESPONSE REGULATOR receiver
ISU57_01715	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISU57_01730	COG1584	GPR1 FUN34 yaaH family protein
ISU57_01750	COG0583	DNA-binding transcription factor activity
ISU57_01760	COG0196	riboflavin kinase activity
ISU57_01775	COG1047	Peptidyl-prolyl cis-trans
ISU57_01800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISU57_01805	COG1280	lysine exporter protein (LysE YggA)
ISU57_01810	COG2966	Psort location CytoplasmicMembrane, score
ISU57_01820	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISU57_01870	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISU57_01875	COG0564	pseudouridine synthase activity
ISU57_01960	COG2885	chlorophyll binding
ISU57_01960	COG3047	cAMP biosynthetic process
ISU57_01980	COG0417	DNA replication proofreading
ISU57_01985	COG0586	Pfam SNARE associated Golgi protein
ISU57_01990	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ISU57_01995	COG1178	ABC-type Fe3 transport system permease component
ISU57_02000	COG4143	(ABC) transporter
ISU57_02010	COG2814	Major facilitator Superfamily
ISU57_02025	COG0473	3-isopropylmalate dehydrogenase activity
ISU57_02050	COG1022	Amp-dependent synthetase and ligase
ISU57_02055	COG0028	Belongs to the TPP enzyme family
ISU57_02070	COG1609	Transcriptional regulator
ISU57_02095	COG3116	cell division
ISU57_02100	COG0768	penicillin binding
ISU57_02105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISU57_02110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISU57_02125	COG0772	Belongs to the SEDS family
ISU57_02145	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISU57_02150	COG0849	cell division
ISU57_02155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISU57_02185	COG0494	nUDIX hydrolase
ISU57_02205	COG2259	Doxx family
ISU57_02215	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISU57_02220	COG4575	ribosome binding
ISU57_02235	COG0586	Pfam SNARE associated Golgi protein
ISU57_02250	COG2271	Major facilitator Superfamily
ISU57_02265	COG2721	sulfolactate sulfo-lyase activity
ISU57_02285	COG0673	inositol 2-dehydrogenase activity
ISU57_02290	COG1451	nucleotide metabolic process
ISU57_02305	COG1902	pentaerythritol trinitrate reductase activity
ISU57_02305	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISU57_02310	COG3247	response to pH
ISU57_02325	COG4245	von Willebrand factor, type A
ISU57_02340	COG4245	von Willebrand factor, type A
ISU57_02345	COG2831	hemolysin activation secretion protein
ISU57_02350	COG3210	domain, Protein
ISU57_02380	COG3210	domain, Protein
ISU57_02385	COG3210	domain, Protein
ISU57_02405	COG3842	ATPase activity
ISU57_02410	COG3459	Glycosyltransferase 36 associated
ISU57_02415	COG1609	Transcriptional regulator
ISU57_02420	COG2182	Extracellular solute-binding protein
ISU57_02430	COG0395	ABC-type sugar transport system, permease component
ISU57_02450	COG1289	transmembrane transporter activity
ISU57_02470	COG0436	Aminotransferase
ISU57_02490	COG0251	oxidation-reduction process
ISU57_02560	COG0358	DNA primase activity
ISU57_02565	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISU57_02580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISU57_02595	COG4991	sh3 domain protein
ISU57_02600	COG3025	triphosphatase activity
ISU57_02615	COG0531	amino acid
ISU57_02635	COG3384	dioxygenase
ISU57_02640	COG0754	glutathionylspermidine amidase activity
ISU57_02650	COG1538	Outer membrane efflux protein
ISU57_02655	COG0494	nUDIX hydrolase
ISU57_02660	COG3151	Protein conserved in bacteria
ISU57_02665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISU57_02670	COG3150	esterase
ISU57_02680	COG0583	DNA-binding transcription factor activity
ISU57_02685	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISU57_02695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISU57_02705	COG2132	Multicopper oxidase
ISU57_02715	COG0656	L-ascorbic acid biosynthetic process
ISU57_02725	COG1979	alcohol dehydrogenase
ISU57_02730	COG2207	Transcriptional regulator
ISU57_02735	COG0586	Pfam SNARE associated Golgi protein
ISU57_02740	COG0626	cystathionine gamma-synthase activity
ISU57_02745	COG0811	peptide transport
ISU57_02750	COG0848	biopolymer transport protein
ISU57_02800	COG4964	Belongs to the GSP D family
ISU57_02805	COG4964	Belongs to the GSP D family
ISU57_02840	COG4592	Periplasmic binding protein
ISU57_02860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU57_02865	COG1684	flagellar biosynthetic protein fliR
ISU57_02870	COG1987	bacterial-type flagellum assembly
ISU57_02895	COG1677	Flagellar hook-basal body complex protein FliE
ISU57_02935	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ISU57_02940	COG1815	bacterial-type flagellum-dependent cell motility
ISU57_02945	COG1558	bacterial-type flagellum-dependent cell motility
ISU57_02950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ISU57_02955	COG1749	Flagellar hook protein flgE
ISU57_02960	COG4787	bacterial-type flagellum-dependent cell motility
ISU57_02965	COG4786	Flagellar basal body rod
ISU57_02975	COG1706	bacterial-type flagellum-dependent cell motility
ISU57_02985	COG1256	bacterial-type flagellum assembly
ISU57_03005	COG3710	Transcriptional regulator
ISU57_03030	COG0471	metal ion transport
ISU57_03055	COG3501	Rhs element vgr protein
ISU57_03070	COG2610	gluconate transmembrane transporter activity
ISU57_03085	COG1132	(ABC) transporter
ISU57_03090	COG2375	cellular response to nickel ion
ISU57_03090	COG1132	(ABC) transporter
ISU57_03115	COG3433	isochorismatase activity
ISU57_03115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU57_03115	COG2226	methyltransferase
ISU57_03125	COG2226	methyltransferase
ISU57_03125	COG3433	isochorismatase activity
ISU57_03125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU57_03145	COG4771	TonB-dependent receptor
ISU57_03150	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU57_03155	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISU57_03200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU57_03210	COG5001	Diguanylate cyclase
ISU57_03220	COG2211	Major facilitator Superfamily
ISU57_03270	COG2771	luxR family
ISU57_03275	COG3916	Acyl-homoserine-lactone synthase
ISU57_03395	COG1982	Orn Lys Arg decarboxylase major
ISU57_03400	COG1879	ABC-type sugar transport system periplasmic component
ISU57_03405	COG1129	ABC transporter
ISU57_03410	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_03415	COG4774	siderophore transport
ISU57_03435	COG1194	a g-specific adenine glycosylase
ISU57_03445	COG3171	Protein conserved in bacteria
ISU57_03465	COG3064	Membrane
ISU57_03465	COG1073	alpha beta
ISU57_03465	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ISU57_03470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU57_03475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISU57_03485	COG0762	integral membrane protein
ISU57_03490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISU57_03495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISU57_03500	COG2805	Type II/IV secretion system protein
ISU57_03510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU57_03525	COG0189	ligase activity
ISU57_03530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISU57_03535	COG2356	endonuclease I
ISU57_03550	COG1166	arginine decarboxylase activity
ISU57_03565	COG0501	Belongs to the peptidase M48B family
ISU57_03570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISU57_03590	COG0191	fructose-bisphosphate aldolase activity
ISU57_03625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISU57_03635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISU57_03655	COG0006	proline dipeptidase activity
ISU57_03660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU57_03665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU57_03710	COG1272	protein, Hemolysin III
ISU57_03735	COG0745	RESPONSE REGULATOR receiver
ISU57_03740	COG2205	protein histidine kinase activity
ISU57_03745	COG4452	Inner membrane protein CreD
ISU57_03750	COG0716	FMN binding
ISU57_03755	COG4974	Belongs to the 'phage' integrase family
ISU57_03760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU57_03765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISU57_03785	COG0582	viral genome integration into host DNA
ISU57_03810	COG2944	sequence-specific DNA binding
ISU57_03900	COG1695	Transcriptional regulator
ISU57_03905	COG0791	NLP P60 protein
ISU57_03915	COG1879	ABC-type sugar transport system periplasmic component
ISU57_03920	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_03925	COG1129	ABC transporter
ISU57_03935	COG2182	Extracellular solute-binding protein
ISU57_03940	COG1175	transmembrane transport
ISU57_03945	COG3833	ABC-type maltose transport systems, permease component
ISU57_03950	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISU57_03955	COG1874	Beta-galactosidase
ISU57_03960	COG1263	PTS System
ISU57_03960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU57_03980	COG2271	Major facilitator Superfamily
ISU57_04005	COG3119	arylsulfatase activity
ISU57_04010	COG0641	radical SAM
ISU57_04020	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_04030	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_04035	COG3716	PTS system mannose fructose sorbose family IID component
ISU57_04040	COG3715	PTS system
ISU57_04045	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU57_04050	COG2222	sugar isomerase
ISU57_04060	COG1349	DNA-binding transcription factor activity
ISU57_04065	COG3119	arylsulfatase activity
ISU57_04105	COG0288	reversible hydration of carbon dioxide
ISU57_04125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU57_04145	COG2165	general secretion pathway protein
ISU57_04190	COG0840	transmembrane signaling receptor activity
ISU57_04205	COG0583	DNA-binding transcription factor activity
ISU57_04210	COG2814	Major facilitator Superfamily
ISU57_04215	COG0583	DNA-binding transcription factor activity
ISU57_04225	COG1609	Transcriptional regulator
ISU57_04255	COG0667	Aldo Keto reductase
ISU57_04305	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISU57_04315	COG1074	ATP-dependent DNA helicase activity
ISU57_04320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISU57_04330	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU57_04345	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISU57_04350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISU57_04355	COG2166	iron-sulfur cluster assembly
ISU57_04360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISU57_04370	COG0583	DNA-binding transcription factor activity
ISU57_04375	COG2363	Small membrane protein
ISU57_04400	COG1611	Belongs to the LOG family
ISU57_04420	COG3098	single-species biofilm formation
ISU57_04425	COG0564	pseudouridine synthase activity
ISU57_04485	COG0575	Belongs to the CDS family
ISU57_04490	COG0750	zinc metalloprotease
ISU57_04505	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU57_04530	COG0587	DNA-directed DNA polymerase activity
ISU57_04540	COG0346	lactoylglutathione lyase activity
ISU57_04545	COG0037	tRNA processing
ISU57_04555	COG4568	rho-dependent transcription termination
ISU57_04565	COG4681	YaeQ
ISU57_04575	COG3015	lipoprotein NlpE involved in copper resistance
ISU57_04585	COG1720	tRNA m6t6A37 methyltransferase activity
ISU57_04595	COG1464	Belongs to the NlpA lipoprotein family
ISU57_04600	COG2011	ABC-type metal ion transport system permease component
ISU57_04610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU57_04640	COG0656	L-ascorbic acid biosynthetic process
ISU57_04655	COG1388	LysM domain
ISU57_04655	COG0741	lytic transglycosylase activity
ISU57_04660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU57_04665	COG2226	methyltransferase
ISU57_04685	COG1953	Uracil, thiamine, allantoin
ISU57_04710	COG3657	addiction module killer protein
ISU57_04760	COG0582	viral genome integration into host DNA
ISU57_04780	COG2867	negative regulation of translational initiation
ISU57_04790	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU57_04795	COG0497	DNA recombination
ISU57_04800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISU57_04815	COG2009	succinate dehydrogenase
ISU57_04820	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISU57_04825	COG1053	succinate dehydrogenase
ISU57_04835	COG0567	Dehydrogenase, E1 component
ISU57_04840	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU57_04850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISU57_04855	COG1271	oxidase subunit
ISU57_04860	COG1294	oxidase, subunit
ISU57_04865	COG4890	Cyd operon protein YbgT
ISU57_04870	COG3790	cyd operon protein YbgE
ISU57_04875	COG0824	Thioesterase
ISU57_04880	COG0811	peptide transport
ISU57_04885	COG0848	biopolymer transport protein
ISU57_04890	COG3064	Membrane
ISU57_04890	COG3064	Membrane
ISU57_04900	COG2885	chlorophyll binding
ISU57_04905	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISU57_04935	COG1230	cation diffusion facilitator family transporter
ISU57_04940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU57_04955	COG2017	converts alpha-aldose to the beta-anomer
ISU57_04970	COG1085	galactose-1-phosphate uridylyltransferase
ISU57_04975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISU57_04985	COG1119	ATPase activity
ISU57_04990	COG3585	molybdate ion transport
ISU57_04990	COG2005	Transcriptional regulator
ISU57_05000	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISU57_05005	COG4149	molybdate abc transporter
ISU57_05015	COG0561	phosphatase activity
ISU57_05040	COG2226	methyltransferase
ISU57_05050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISU57_05060	COG4628	conserved protein (DUF2132)
ISU57_05065	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ISU57_05070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISU57_05080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISU57_05085	COG0314	molybdopterin synthase activity
ISU57_05090	COG0670	Belongs to the BI1 family
ISU57_05105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU57_05115	COG1686	Belongs to the peptidase S11 family
ISU57_05120	COG0277	FAD linked oxidase domain protein
ISU57_05140	COG2261	transglycosylase associated protein
ISU57_05150	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISU57_05165	COG4807	Protein conserved in bacteria
ISU57_05185	COG1122	ATPase activity
ISU57_05205	COG2897	thiosulfate sulfurtransferase activity
ISU57_05210	COG1732	Glycine betaine
ISU57_05215	COG1732	Glycine betaine
ISU57_05220	COG1174	glycine betaine transport
ISU57_05225	COG1125	glycine betaine transport
ISU57_05230	COG1174	glycine betaine transport
ISU57_05235	COG0531	amino acid
ISU57_05240	COG1982	Orn Lys Arg decarboxylase major
ISU57_05250	COG0697	spore germination
ISU57_05275	COG0814	amino acid
ISU57_05290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU57_05315	COG2205	protein histidine kinase activity
ISU57_05315	COG0784	Response regulator, receiver
ISU57_05325	COG2198	Histidine kinase
ISU57_05325	COG0642	Histidine kinase
ISU57_05330	COG0642	Histidine kinase
ISU57_05330	COG2198	Histidine kinase
ISU57_05335	COG2223	nitrite transmembrane transporter activity
ISU57_05360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISU57_05400	COG3395	kinase activity
ISU57_05410	COG1349	DNA-binding transcription factor activity
ISU57_05415	COG3622	Belongs to the hyi family
ISU57_05435	COG4386	tail sheath protein
ISU57_05475	COG3299	homolog of phage Mu protein gp47
ISU57_05495	COG1737	Transcriptional regulator
ISU57_05500	COG2723	6-phospho-beta-galactosidase activity
ISU57_05520	COG3157	Type VI secretion system effector, Hcp
ISU57_05535	COG3083	sulfuric ester hydrolase activity
ISU57_05540	COG3082	Protein of unknown function (DUF1414)
ISU57_05560	COG1061	Type III restriction enzyme res subunit
ISU57_05565	COG1187	pseudouridine synthase activity
ISU57_05570	COG2814	Major facilitator Superfamily
ISU57_05580	COG4172	Belongs to the ABC transporter superfamily
ISU57_05585	COG4239	(ABC) transporter, permease
ISU57_05590	COG4174	ABC transporter (Permease)
ISU57_05595	COG4166	transmembrane transport
ISU57_05600	COG2200	EAL domain
ISU57_05605	COG0791	NLP P60 protein
ISU57_05610	COG0671	phosphoesterase, PA-phosphatase related
ISU57_05615	COG0523	cobalamin synthesis protein
ISU57_05625	COG2186	Transcriptional regulator
ISU57_05630	COG0246	Mannitol dehydrogenase
ISU57_05655	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_05690	COG1129	ABC transporter
ISU57_05700	COG0494	nUDIX hydrolase
ISU57_05710	COG1105	Belongs to the carbohydrate kinase PfkB family
ISU57_05715	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISU57_05715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU57_05715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU57_05720	COG3710	Transcriptional regulator
ISU57_05735	COG3121	Chaperone
ISU57_05740	COG3188	usher protein
ISU57_05750	COG2855	membrane
ISU57_05755	COG0583	DNA-binding transcription factor activity
ISU57_05760	COG0833	amino acid
ISU57_05770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_05780	COG4771	TonB-dependent receptor
ISU57_05785	COG0625	glutathione transferase activity
ISU57_05810	COG2011	ABC-type metal ion transport system permease component
ISU57_05815	COG1686	Belongs to the peptidase S11 family
ISU57_05825	COG0814	amino acid
ISU57_05830	COG1349	DNA-binding transcription factor activity
ISU57_05840	COG0671	phosphoesterase, PA-phosphatase related
ISU57_05870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISU57_05875	COG3842	ATPase activity
ISU57_05880	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU57_05885	COG1177	transmembrane transport
ISU57_05900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_05925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_05930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_05935	COG1120	ATPase activity
ISU57_05960	COG4160	amino acid transport
ISU57_05965	COG4215	(ABC) transporter
ISU57_05970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_05975	COG1126	abc transporter atp-binding protein
ISU57_05980	COG1605	Chorismate mutase
ISU57_05990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU57_05995	COG0702	epimerase
ISU57_06000	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISU57_06010	COG0028	Belongs to the TPP enzyme family
ISU57_06015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU57_06025	COG2431	L-lysine efflux transmembrane transporter activity
ISU57_06030	COG3593	DNA synthesis involved in DNA repair
ISU57_06035	COG2990	Protein conserved in bacteria
ISU57_06040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU57_06050	COG1278	Cold shock
ISU57_06060	COG0542	response to heat
ISU57_06070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ISU57_06080	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISU57_06090	COG0492	ferredoxin-NADP+ reductase activity
ISU57_06100	COG1674	ftsk spoiiie
ISU57_06100	COG3107	peptidoglycan biosynthetic process
ISU57_06110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISU57_06140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISU57_06150	COG1882	Formate acetyltransferase
ISU57_06155	COG2116	formate transmembrane transporter activity
ISU57_06160	COG1944	ATP diphosphatase activity
ISU57_06165	COG0252	asparaginase activity
ISU57_06170	COG5295	Hep Hag repeat protein
ISU57_06170	COG5295	Hep Hag repeat protein
ISU57_06195	COG0539	negative regulation of cytoplasmic translation
ISU57_06205	COG0658	competence protein
ISU57_06205	COG2333	competence protein COMEC
ISU57_06220	COG5383	Protein conserved in bacteria
ISU57_06225	COG1278	Cold shock
ISU57_06240	COG3173	Aminoglycoside phosphotransferase
ISU57_06245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISU57_06270	COG2989	Protein conserved in bacteria
ISU57_06275	COG3108	Peptidase M15
ISU57_06280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU57_06290	COG1448	Aminotransferase
ISU57_06310	COG0308	aminopeptidase N
ISU57_06325	COG3217	Mosc domain protein beta barrel domain protein
ISU57_06325	COG0633	Ferredoxin
ISU57_06335	COG0488	(ABC) transporter
ISU57_06340	COG2995	paraquat-inducible protein a
ISU57_06345	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU57_06345	COG3008	intermembrane lipid transfer
ISU57_06350	COG3009	Protein conserved in bacteria
ISU57_06355	COG3130	regulation of translation
ISU57_06395	COG1067	ATP-dependent peptidase activity
ISU57_06420	COG3070	regulator of competence-specific genes
ISU57_06425	COG1289	transmembrane transporter activity
ISU57_06430	COG3304	Inner membrane component domain
ISU57_06435	COG0210	DNA helicase
ISU57_06450	COG1832	CoA-binding protein
ISU57_06470	COG2920	part of a sulfur-relay system
ISU57_06495	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_06505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISU57_06510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU57_06515	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_06520	COG3425	synthase
ISU57_06530	COG1024	Enoyl-CoA hydratase
ISU57_06535	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_06545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISU57_06550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISU57_06680	COG0488	(ABC) transporter
ISU57_06690	COG3328	transposase activity
ISU57_06700	COG0303	'Molybdopterin
ISU57_06710	COG1136	(ABC) transporter
ISU57_06740	COG0583	DNA-binding transcription factor activity
ISU57_06745	COG0477	Major facilitator Superfamily
ISU57_06755	COG2311	Membrane
ISU57_06770	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISU57_06775	COG2949	membrane
ISU57_06790	COG1346	cytolysis
ISU57_06800	COG2814	Major facilitator Superfamily
ISU57_06830	COG0489	protein tyrosine kinase activity
ISU57_06845	COG2982	Protein involved in outer membrane biogenesis
ISU57_06850	COG1253	flavin adenine dinucleotide binding
ISU57_06855	COG4114	ferric iron reductase
ISU57_06860	COG0076	glutamate decarboxylase activity
ISU57_06865	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ISU57_06880	COG1120	ATPase activity
ISU57_06885	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_06890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_06895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU57_06910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU57_06915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU57_06925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISU57_06925	COG0140	phosphoribosyl-ATP diphosphatase activity
ISU57_06945	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU57_06945	COG0131	Imidazoleglycerol-phosphate dehydratase
ISU57_06955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISU57_06970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU57_06985	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_06990	COG1129	ABC transporter
ISU57_06995	COG1129	ABC transporter
ISU57_07000	COG0371	Dehydrogenase
ISU57_07005	COG0531	amino acid
ISU57_07015	COG2925	Exonuclease
ISU57_07030	COG3328	transposase activity
ISU57_07035	COG1388	LysM domain
ISU57_07035	COG1470	cell adhesion involved in biofilm formation
ISU57_07040	COG2271	Major facilitator Superfamily
ISU57_07045	COG3011	Protein conserved in bacteria
ISU57_07050	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_07060	COG4948	Mandelate Racemase Muconate Lactonizing
ISU57_07075	COG0534	Mate efflux family protein
ISU57_07095	COG3122	Protein conserved in bacteria
ISU57_07120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISU57_07140	COG2223	nitrite transmembrane transporter activity
ISU57_07145	COG3328	transposase activity
ISU57_07170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU57_07170	COG1017	nitric oxide dioxygenase activity
ISU57_07190	COG2814	Major facilitator Superfamily
ISU57_07195	COG3711	transcriptional antiterminator
ISU57_07200	COG3683	transport system, periplasmic component
ISU57_07205	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU57_07225	COG1104	cysteine desulfurase activity
ISU57_07230	COG0822	iron-sulfur transferase activity
ISU57_07250	COG0633	Ferredoxin
ISU57_07255	COG2975	iron-sulfur cluster assembly
ISU57_07280	COG3468	outer membrane autotransporter barrel domain protein
ISU57_07285	COG3468	outer membrane autotransporter barrel domain protein
ISU57_07325	COG2976	Protein conserved in bacteria
ISU57_07330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU57_07345	COG1645	bacterial-type flagellum-dependent swarming motility
ISU57_07355	COG0516	GMP reductase activity
ISU57_07355	COG0517	IMP dehydrogenase activity
ISU57_07400	COG3328	transposase activity
ISU57_07415	COG0351	phosphomethylpyrimidine kinase
ISU57_07445	COG0826	peptidase U32
ISU57_07450	COG3422	double-strand break repair
ISU57_07455	COG0745	RESPONSE REGULATOR receiver
ISU57_07485	COG3842	ATPase activity
ISU57_07495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISU57_07505	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU57_07510	COG1177	transmembrane transport
ISU57_07515	COG0443	Heat shock 70 kDa protein
ISU57_07520	COG2239	Acts as a magnesium transporter
ISU57_07535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISU57_07545	COG0581	inorganic phosphate transmembrane transporter activity
ISU57_07560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU57_07565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISU57_07590	COG1393	Belongs to the ArsC family
ISU57_07595	COG4783	chaperone-mediated protein folding
ISU57_07600	COG0628	permease
ISU57_07610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISU57_07615	COG2716	regulation of RNA biosynthetic process
ISU57_07625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISU57_07640	COG2321	neutral zinc metallopeptidase
ISU57_07660	COG1876	peptidase activity
ISU57_07670	COG1393	Belongs to the ArsC family
ISU57_07685	COG1175	transmembrane transport
ISU57_07690	COG3842	ATPase activity
ISU57_07700	COG3119	arylsulfatase activity
ISU57_07705	COG0641	radical SAM
ISU57_07710	COG1988	membrane-bound metal-dependent
ISU57_07720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU57_07730	COG2197	response regulator
ISU57_07735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU57_07735	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU57_07740	COG3062	negative regulation of establishment of protein localization
ISU57_07750	COG3043	anaerobic respiration
ISU57_07755	COG3005	denitrification pathway
ISU57_07795	COG3111	PFAM Bacterial OB fold (BOF) protein
ISU57_07805	COG2837	iron assimilation
ISU57_07810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISU57_07820	COG4886	Leucine-rich repeat (LRR) protein
ISU57_07830	COG2731	YhcH YjgK YiaL family protein
ISU57_07835	COG1737	Transcriptional regulator
ISU57_07845	COG4150	thiosulfate binding
ISU57_07850	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISU57_07855	COG4208	sulfate ABC transporter
ISU57_07860	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISU57_07875	COG0745	RESPONSE REGULATOR receiver
ISU57_07880	COG3850	Histidine kinase
ISU57_07880	COG5002	protein histidine kinase activity
ISU57_07890	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISU57_07910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISU57_07925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU57_07930	COG0745	RESPONSE REGULATOR receiver
ISU57_07935	COG2205	protein histidine kinase activity
ISU57_07955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_07965	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ISU57_07980	COG3530	Putative quorum-sensing-regulated virulence factor
ISU57_08045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU57_08060	COG0667	Aldo Keto reductase
ISU57_08085	COG0436	Aminotransferase
ISU57_08090	COG3038	cytochrome b561
ISU57_08120	COG3381	protein complex oligomerization
ISU57_08125	COG3302	dmso reductase anchor subunit
ISU57_08130	COG0437	4 iron, 4 sulfur cluster binding
ISU57_08135	COG0243	molybdopterin cofactor binding
ISU57_08170	COG2951	lytic endotransglycosylase activity
ISU57_08235	COG3121	Chaperone
ISU57_08240	COG3188	usher protein
ISU57_08245	COG3328	transposase activity
ISU57_08250	COG3188	usher protein
ISU57_08340	COG2824	Alkylphosphonate utilization operon protein PhnA
ISU57_08350	COG1704	LemA family
ISU57_08370	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU57_08375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU57_08380	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU57_08390	COG1138	Cytochrome C-type biogenesis protein
ISU57_08395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU57_08400	COG3088	subunit of a heme lyase
ISU57_08400	COG4235	cytochrome complex assembly
ISU57_08405	COG3088	subunit of a heme lyase
ISU57_08405	COG4235	cytochrome complex assembly
ISU57_08420	COG3691	Protein conserved in bacteria
ISU57_08435	COG2062	phosphohistidine phosphatase, SixA
ISU57_08445	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU57_08460	COG0730	response to heat
ISU57_08465	COG3101	peptidyl-lysine hydroxylation
ISU57_08480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU57_08485	COG1794	racemase activity, acting on amino acids and derivatives
ISU57_08500	COG0697	spore germination
ISU57_08515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU57_08525	COG0586	Pfam SNARE associated Golgi protein
ISU57_08535	COG0285	dihydrofolate synthase activity
ISU57_08540	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISU57_08545	COG1286	toxin biosynthetic process
ISU57_08550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISU57_08560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_08565	COG4215	(ABC) transporter
ISU57_08570	COG4160	amino acid transport
ISU57_08575	COG4598	ABC transporter
ISU57_08580	COG1090	epimerase
ISU57_08590	COG0622	Phosphoesterase
ISU57_08595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISU57_08600	COG3037	sugar-specific permease SgaT UlaA
ISU57_08615	COG1609	Transcriptional regulator
ISU57_08620	COG0280	phosphate acetyltransferase
ISU57_08620	COG0857	belongs to the CobB CobQ family
ISU57_08640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU57_08645	COG0490	domain, Protein
ISU57_08645	COG0471	metal ion transport
ISU57_08660	COG0436	Aminotransferase
ISU57_08665	COG0583	DNA-binding transcription factor activity
ISU57_08675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU57_08695	COG1034	ATP synthesis coupled electron transport
ISU57_08710	COG0839	Belongs to the complex I subunit 6 family
ISU57_08720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISU57_08725	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU57_08745	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_08750	COG3265	gluconokinase activity
ISU57_08765	COG1649	PFAM Uncharacterised BCR, COG1649
ISU57_08770	COG1609	Transcriptional regulator
ISU57_08775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU57_08790	COG0129	dihydroxy-acid dehydratase activity
ISU57_08795	COG4575	ribosome binding
ISU57_08805	COG1169	isochorismate synthase
ISU57_08820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ISU57_08835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISU57_08870	COG1126	abc transporter atp-binding protein
ISU57_08875	COG0765	amino acid transport
ISU57_08880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_08910	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISU57_08930	COG1063	alcohol dehydrogenase
ISU57_08935	COG1879	ABC-type sugar transport system periplasmic component
ISU57_08940	COG1129	ABC transporter
ISU57_08945	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_08950	COG1609	Transcriptional regulator
ISU57_08955	COG0583	DNA-binding transcription factor activity
ISU57_08960	COG0473	3-isopropylmalate dehydrogenase activity
ISU57_08970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISU57_08980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU57_08985	COG2831	hemolysin activation secretion protein
ISU57_08990	COG3210	domain, Protein
ISU57_09030	COG3210	domain, Protein
ISU57_09040	COG3842	ATPase activity
ISU57_09050	COG1609	Transcriptional regulator
ISU57_09065	COG0395	ABC-type sugar transport system, permease component
ISU57_09070	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ISU57_09095	COG0668	transmembrane transport
ISU57_09100	COG1518	maintenance of DNA repeat elements
ISU57_09105	COG1203	CRISPR-associated helicase, Cas3
ISU57_09130	COG0667	Aldo Keto reductase
ISU57_09140	COG0477	Major facilitator Superfamily
ISU57_09150	COG0583	DNA-binding transcription factor activity
ISU57_09155	COG2771	luxR family
ISU57_09160	COG3916	Acyl-homoserine-lactone synthase
ISU57_09180	COG0628	permease
ISU57_09200	COG3328	transposase activity
ISU57_09210	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISU57_09230	COG3328	transposase activity
ISU57_09235	COG1530	ribonuclease E activity
ISU57_09240	COG0564	pseudouridine synthase activity
ISU57_09245	COG0424	maF-like protein
ISU57_09250	COG1399	metal-binding, possibly nucleic acid-binding protein
ISU57_09255	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISU57_09285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU57_09295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU57_09300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISU57_09310	COG0470	DNA polymerase III
ISU57_09315	COG0084	hydrolase, TatD family'
ISU57_09320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU57_09320	COG1263	PTS System
ISU57_09330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISU57_09335	COG0537	adenosine 5'-monophosphoramidase activity
ISU57_09340	COG5633	Lipoprotein
ISU57_09355	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU57_09365	COG1252	NADH dehydrogenase
ISU57_09380	COG3328	transposase activity
ISU57_09385	COG3134	Outer membrane lipoprotein
ISU57_09390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISU57_09395	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU57_09405	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU57_09410	COG1940	carbohydrate kinase activity
ISU57_09430	COG2850	peptidyl-arginine hydroxylation
ISU57_09440	COG0745	RESPONSE REGULATOR receiver
ISU57_09450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISU57_09470	COG1187	pseudouridine synthase activity
ISU57_09475	COG0538	isocitrate dehydrogenase activity
ISU57_09490	COG0840	transmembrane signaling receptor activity
ISU57_09495	COG0702	epimerase
ISU57_09500	COG1733	regulation of RNA biosynthetic process
ISU57_09525	COG1522	sequence-specific DNA binding
ISU57_09540	COG0604	alcohol dehydrogenase
ISU57_09540	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_09540	COG3321	synthase
ISU57_09565	COG1285	pathogenesis
ISU57_09590	COG1360	Flagellar Motor Protein
ISU57_09595	COG0643	Histidine kinase
ISU57_09595	COG2198	Histidine kinase
ISU57_09600	COG0835	chemotaxis
ISU57_09605	COG2271	Major facilitator Superfamily
ISU57_09610	COG0251	oxidation-reduction process
ISU57_09620	COG2964	Protein conserved in bacteria
ISU57_09640	COG0840	transmembrane signaling receptor activity
ISU57_09645	COG0840	transmembrane signaling receptor activity
ISU57_09650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ISU57_09660	COG0745	RESPONSE REGULATOR receiver
ISU57_09665	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISU57_09670	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU57_09680	COG5295	Hep Hag repeat protein
ISU57_09690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISU57_09745	COG3121	Chaperone
ISU57_09765	COG3008	intermembrane lipid transfer
ISU57_09770	COG2995	paraquat-inducible protein a
ISU57_09775	COG1956	GAF domain-containing protein
ISU57_09785	COG0793	Belongs to the peptidase S41A family
ISU57_09795	COG3539	Fimbrial protein
ISU57_09800	COG3121	Chaperone
ISU57_09815	COG3121	Chaperone
ISU57_09820	COG2814	Major facilitator Superfamily
ISU57_09825	COG0823	Involved in the tonB-independent uptake of proteins
ISU57_09835	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU57_09840	COG1823	symporter activity
ISU57_09845	COG1988	membrane-bound metal-dependent
ISU57_09850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU57_09855	COG1653	transport
ISU57_09860	COG3842	ATPase activity
ISU57_09865	COG0395	ABC-type sugar transport system, permease component
ISU57_09870	COG1175	transmembrane transport
ISU57_09880	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_09890	COG1917	Cupin 2, conserved barrel domain protein
ISU57_09895	COG3328	transposase activity
ISU57_09915	COG0500	methyltransferase
ISU57_09960	COG5002	protein histidine kinase activity
ISU57_10010	COG0012	GTP binding
ISU57_10025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISU57_10050	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU57_10070	COG0659	secondary active sulfate transmembrane transporter activity
ISU57_10090	COG3833	ABC-type maltose transport systems, permease component
ISU57_10095	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU57_10115	COG0584	glycerophosphoryl diester phosphodiesterase
ISU57_10120	COG1940	carbohydrate kinase activity
ISU57_10135	COG3381	protein complex oligomerization
ISU57_10150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU57_10160	COG0728	peptidoglycan biosynthetic process
ISU57_10180	COG3102	Protein conserved in bacteria
ISU57_10200	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISU57_10205	COG1801	Protein of unknown function DUF72
ISU57_10215	COG0494	nUDIX hydrolase
ISU57_10240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU57_10250	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISU57_10255	COG0739	heme binding
ISU57_10260	COG1560	Kdo2-lipid A biosynthetic process
ISU57_10270	COG0469	pyruvate kinase activity
ISU57_10275	COG1737	Transcriptional regulator
ISU57_10280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISU57_10285	COG0800	Aldolase
ISU57_10300	COG0251	oxidation-reduction process
ISU57_10305	COG1199	ATP-dependent helicase activity
ISU57_10315	COG3065	identical protein binding
ISU57_10325	COG0318	PFAM AMP-dependent synthetase and ligase
ISU57_10330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ISU57_10335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISU57_10340	COG2894	cell division
ISU57_10355	COG2951	lytic endotransglycosylase activity
ISU57_10360	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISU57_10370	COG0582	viral genome integration into host DNA
ISU57_10470	COG3328	transposase activity
ISU57_10630	COG3328	transposase activity
ISU57_10640	COG1104	cysteine desulfurase activity
ISU57_10670	COG2719	SpoVR family
ISU57_10680	COG2814	Major facilitator Superfamily
ISU57_10690	COG0583	DNA-binding transcription factor activity
ISU57_10705	COG2766	serine protein kinase
ISU57_10710	COG3713	MltA-interacting MipA family protein
ISU57_10730	COG3139	Protein of unknown function (DUF1315)
ISU57_10735	COG1335	isochorismatase
ISU57_10740	COG0252	asparaginase activity
ISU57_10745	COG0616	signal peptide processing
ISU57_10750	COG0778	Nitroreductase
ISU57_10755	COG0709	Synthesizes selenophosphate from selenide and ATP
ISU57_10760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISU57_10770	COG0494	nUDIX hydrolase
ISU57_10775	COG0708	Exodeoxyribonuclease III
ISU57_10780	COG0583	DNA-binding transcription factor activity
ISU57_10800	COG3328	transposase activity
ISU57_10805	COG0788	formyltetrahydrofolate deformylase activity
ISU57_10815	COG0745	RESPONSE REGULATOR receiver
ISU57_10850	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISU57_10855	COG2205	protein histidine kinase activity
ISU57_10860	COG0745	RESPONSE REGULATOR receiver
ISU57_10870	COG0531	amino acid
ISU57_10880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISU57_10885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISU57_10890	COG0589	response to stress
ISU57_10895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISU57_10900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU57_10915	COG1011	Hydrolase
ISU57_10920	COG0440	acetolactate synthase activity
ISU57_10925	COG0028	Belongs to the TPP enzyme family
ISU57_10955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISU57_10965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU57_10985	COG1609	Transcriptional regulator
ISU57_10990	COG0038	chloride channel
ISU57_10995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISU57_11000	COG1940	carbohydrate kinase activity
ISU57_11005	COG0583	DNA-binding transcription factor activity
ISU57_11010	COG2814	Major facilitator Superfamily
ISU57_11020	COG0114	fumarate hydratase activity
ISU57_11030	COG5339	Protein conserved in bacteria
ISU57_11040	COG0385	Bile acid
ISU57_11045	COG0673	inositol 2-dehydrogenase activity
ISU57_11055	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_11060	COG1129	ABC transporter
ISU57_11065	COG1879	ABC-type sugar transport system periplasmic component
ISU57_11080	COG2274	protein secretion by the type I secretion system
ISU57_11085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU57_11095	COG2274	protein secretion by the type I secretion system
ISU57_11130	COG2207	Transcriptional regulator
ISU57_11130	COG3708	Transcriptional regulator
ISU57_11135	COG4658	electron transport chain
ISU57_11140	COG4659	FMN binding
ISU57_11150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISU57_11155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU57_11160	COG2271	Major facilitator Superfamily
ISU57_11170	COG1966	Carbon starvation protein
ISU57_11175	COG2879	small protein
ISU57_11180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISU57_11200	COG0023	Translation Initiation Factor
ISU57_11215	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISU57_11220	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISU57_11225	COG0671	phosphoesterase, PA-phosphatase related
ISU57_11235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISU57_11245	COG0583	DNA-binding transcription factor activity
ISU57_11265	COG0616	signal peptide processing
ISU57_11270	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_11280	COG1187	pseudouridine synthase activity
ISU57_11285	COG0009	L-threonylcarbamoyladenylate synthase
ISU57_11305	COG0512	Glutamine amidotransferase of anthranilate synthase
ISU57_11315	COG0135	phosphoribosylanthranilate isomerase activity
ISU57_11315	COG0134	indole-3-glycerol-phosphate synthase activity
ISU57_11335	COG3047	cAMP biosynthetic process
ISU57_11370	COG3328	transposase activity
ISU57_11375	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ISU57_11380	COG2350	Protein conserved in bacteria
ISU57_11425	COG4608	Belongs to the ABC transporter superfamily
ISU57_11430	COG0444	Belongs to the ABC transporter superfamily
ISU57_11435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU57_11440	COG0601	transmembrane transport
ISU57_11450	COG2095	MarC family integral membrane protein
ISU57_11455	COG1454	alcohol dehydrogenase
ISU57_11455	COG1012	belongs to the aldehyde dehydrogenase family
ISU57_11495	COG3591	Belongs to the peptidase S1B family
ISU57_11510	COG1643	Atp-dependent helicase
ISU57_11520	COG2390	Transcriptional regulator
ISU57_11525	COG0246	Mannitol dehydrogenase
ISU57_11530	COG3784	Protein of unknown function (DUF1318)
ISU57_11540	COG2911	Protein conserved in bacteria
ISU57_11545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU57_11550	COG3187	Heat shock protein
ISU57_11555	COG3042	response to heat
ISU57_11560	COG1285	pathogenesis
ISU57_11570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU57_11570	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISU57_11570	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISU57_11570	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISU57_11580	COG0657	acetylesterase activity
ISU57_11595	COG4166	transmembrane transport
ISU57_11600	COG2866	Carboxypeptidase
ISU57_11605	COG4948	Mandelate Racemase Muconate Lactonizing
ISU57_11610	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISU57_11625	COG5642	Protein of unknown function (DUF2384)
ISU57_11630	COG5654	RES domain protein
ISU57_11640	COG3106	COG3106 Predicted ATPase
ISU57_11650	COG1983	PspC domain protein
ISU57_11660	COG1842	Phage shock protein A
ISU57_11665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISU57_11675	COG4166	transmembrane transport
ISU57_11680	COG4168	peptide transport system, permease
ISU57_11685	COG4171	peptide transport system, permease
ISU57_11695	COG4172	Belongs to the ABC transporter superfamily
ISU57_11700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU57_11700	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU57_11705	COG3104	oligopeptide transport
ISU57_11720	COG0625	glutathione transferase activity
ISU57_11740	COG3895	Periplasmic Protein
ISU57_11750	COG3133	Outer membrane lipoprotein
ISU57_11760	COG2194	sulfuric ester hydrolase activity
ISU57_11765	COG1309	transcriptional regulator
ISU57_11775	COG0346	lactoylglutathione lyase activity
ISU57_11780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISU57_11790	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISU57_11795	COG0791	NLP P60 protein
ISU57_11815	COG0583	DNA-binding transcription factor activity
ISU57_11820	COG2814	Major facilitator Superfamily
ISU57_11825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISU57_11830	COG0307	riboflavin synthase, alpha
ISU57_11885	COG1376	ErfK ybiS ycfS ynhG family protein
ISU57_11885	COG1388	LysM domain
ISU57_11900	COG0719	Fe-S assembly protein
ISU57_11905	COG0396	ATPase activity
ISU57_11910	COG0719	Fe-S assembly protein
ISU57_11915	COG0316	Belongs to the HesB IscA family
ISU57_11920	COG2050	protein possibly involved in aromatic compounds catabolism
ISU57_11925	COG0277	FAD linked oxidase domain protein
ISU57_11925	COG0247	lactate metabolic process
ISU57_11930	COG0628	permease
ISU57_11940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU57_11940	COG0574	Belongs to the PEP-utilizing enzyme family
ISU57_11965	COG0791	NLP P60 protein
ISU57_12015	COG0386	Belongs to the glutathione peroxidase family
ISU57_12030	COG0776	regulation of translation
ISU57_12035	COG0072	phenylalanine-tRNA ligase activity
ISU57_12035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISU57_12070	COG4249	Peptidase C14 caspase catalytic subunit p20
ISU57_12090	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISU57_12095	COG1121	(ABC) transporter
ISU57_12100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU57_12105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU57_12115	COG3001	Fructosamine kinase
ISU57_12125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU57_12130	COG3328	transposase activity
ISU57_12175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU57_12180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU57_12185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU57_12200	COG0402	S-adenosylhomocysteine deaminase activity
ISU57_12250	COG3842	ATPase activity
ISU57_12255	COG0395	ABC-type sugar transport system, permease component
ISU57_12260	COG1175	transmembrane transport
ISU57_12270	COG0673	inositol 2-dehydrogenase activity
ISU57_12275	COG2188	Transcriptional regulator
ISU57_12400	COG2197	response regulator
ISU57_12410	COG3136	membrane protein required for alginate biosynthesis
ISU57_12430	COG1113	amino acid transport
ISU57_12450	COG2822	iron ion transport
ISU57_12455	COG0672	)-iron permease
ISU57_12470	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU57_12470	COG0506	proline dehydrogenase activity
ISU57_12470	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU57_12485	COG1126	abc transporter atp-binding protein
ISU57_12490	COG0765	amino acid transport
ISU57_12495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_12510	COG1191	sigma factor activity
ISU57_12540	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ISU57_12545	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISU57_12550	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISU57_12570	COG1677	Flagellar hook-basal body complex protein FliE
ISU57_12590	COG1157	protein secretion by the type III secretion system
ISU57_12605	COG1580	Controls the rotational direction of flagella during chemotaxis
ISU57_12630	COG1987	bacterial-type flagellum assembly
ISU57_12650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU57_12655	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_12660	COG1129	ABC transporter
ISU57_12670	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_12675	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_12675	COG3347	Dehydrogenase
ISU57_12680	COG2390	Transcriptional regulator
ISU57_12690	COG1256	bacterial-type flagellum assembly
ISU57_12730	COG1558	bacterial-type flagellum-dependent cell motility
ISU57_12735	COG1815	bacterial-type flagellum-dependent cell motility
ISU57_12745	COG2747	anti-sigma28 factor FlgM
ISU57_12750	COG3418	PFAM FlgN family protein
ISU57_12775	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU57_12780	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU57_12805	COG2372	response to copper ion
ISU57_12810	COG1528	Iron-storage protein
ISU57_12825	COG1770	oligopeptidase
ISU57_12840	COG3141	response to X-ray
ISU57_12845	COG0513	Belongs to the DEAD box helicase family
ISU57_12870	COG1760	l-serine dehydratase
ISU57_12875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISU57_12880	COG2368	4-hydroxyphenylacetate
ISU57_12895	COG3971	2-oxopent-4-enoate hydratase activity
ISU57_12905	COG3384	dioxygenase
ISU57_12910	COG1012	belongs to the aldehyde dehydrogenase family
ISU57_12925	COG1846	Transcriptional regulator
ISU57_12930	COG1253	flavin adenine dinucleotide binding
ISU57_12935	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_12935	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU57_12940	COG3715	PTS system
ISU57_12945	COG3716	PTS system mannose fructose sorbose family IID component
ISU57_12975	COG2226	methyltransferase
ISU57_12980	COG1496	oxidoreductase activity
ISU57_13000	COG1113	amino acid transport
ISU57_13035	COG2207	Transcriptional regulator
ISU57_13045	COG1132	(ABC) transporter
ISU57_13090	COG0347	Belongs to the P(II) protein family
ISU57_13095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU57_13095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISU57_13100	COG2204	response regulator
ISU57_13105	COG3170	Tfp pilus assembly protein FimV
ISU57_13110	COG2205	protein histidine kinase activity
ISU57_13155	COG0560	Phosphoserine phosphatase
ISU57_13165	COG1737	Transcriptional regulator
ISU57_13170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU57_13185	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISU57_13220	COG3086	response to oxidative stress
ISU57_13225	COG3026	antisigma factor binding
ISU57_13240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISU57_13250	COG0513	Belongs to the DEAD box helicase family
ISU57_13295	COG1984	allophanate hydrolase subunit 2
ISU57_13310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ISU57_13315	COG5212	phosphodiesterase
ISU57_13325	COG3272	Protein of unknown function (DUF1722)
ISU57_13360	COG2205	protein histidine kinase activity
ISU57_13365	COG0745	RESPONSE REGULATOR receiver
ISU57_13380	COG0033	Phosphoglucomutase
ISU57_13385	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ISU57_13400	COG1917	Cupin 2, conserved barrel domain protein
ISU57_13400	COG2169	Transcriptional regulator
ISU57_13405	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISU57_13410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU57_13415	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU57_13425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU57_13435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU57_13445	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU57_13450	COG4413	Urea transporter
ISU57_13460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISU57_13485	COG0831	urea catabolic process
ISU57_13490	COG1124	(ABC) transporter
ISU57_13495	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ISU57_13500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU57_13510	COG0747	negative chemotaxis
ISU57_13515	COG1278	Cold shock
ISU57_13555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISU57_13560	COG4175	Glycine betaine
ISU57_13565	COG4176	ABC-type proline glycine betaine transport system permease component
ISU57_13570	COG2113	Glycine betaine
ISU57_13605	COG0582	viral genome integration into host DNA
ISU57_13615	COG0596	Alpha beta hydrolase
ISU57_13630	COG0735	belongs to the Fur family
ISU57_13655	COG1263	PTS System
ISU57_13655	COG2190	(PTS) system
ISU57_13655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU57_13665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISU57_13670	COG1940	carbohydrate kinase activity
ISU57_13670	COG1846	Transcriptional regulator
ISU57_13675	COG0647	UMP catabolic process
ISU57_13680	COG0367	asparagine synthase
ISU57_13715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU57_13720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISU57_13725	COG1702	phosphate starvation-inducible protein PhoH
ISU57_13735	COG4535	Mg2 and Co2 transporter CorC
ISU57_13740	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ISU57_13750	COG0765	amino acid transport
ISU57_13755	COG0765	amino acid transport
ISU57_13760	COG1126	abc transporter atp-binding protein
ISU57_13765	COG2888	peptidyl-tyrosine sulfation
ISU57_13780	COG1466	dna polymerase III delta subunit
ISU57_13790	COG0799	negative regulation of ribosome biogenesis
ISU57_13800	COG0768	penicillin binding
ISU57_13805	COG0772	Belongs to the SEDS family
ISU57_13810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU57_13815	COG1686	Belongs to the peptidase S11 family
ISU57_13835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU57_13840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU57_13850	COG1278	Cold shock
ISU57_13855	COG2197	response regulator
ISU57_13880	COG5265	(ABC) transporter
ISU57_13890	COG3718	enzyme involved in inositol metabolism
ISU57_13900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU57_13905	COG0673	inositol 2-dehydrogenase activity
ISU57_13910	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_13915	COG1129	ABC transporter
ISU57_13930	COG3962	Belongs to the TPP enzyme family
ISU57_13950	COG2373	Large extracellular alpha-helical protein
ISU57_13960	COG4953	penicillin-binding protein 1C
ISU57_13965	COG3423	Transcriptional regulator
ISU57_14020	COG3328	transposase activity
ISU57_14035	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU57_14045	COG0656	L-ascorbic acid biosynthetic process
ISU57_14050	COG0667	Aldo Keto reductase
ISU57_14080	COG2453	phosphatase
ISU57_14080	COG0671	phosphoesterase, PA-phosphatase related
ISU57_14085	COG2267	carboxylic ester hydrolase activity
ISU57_14095	COG4589	Belongs to the CDS family
ISU57_14100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISU57_14110	COG0582	viral genome integration into host DNA
ISU57_14145	COG2501	S4 domain
ISU57_14160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU57_14170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISU57_14175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISU57_14180	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISU57_14185	COG4181	ATPase activity
ISU57_14190	COG2755	lipolytic protein G-D-S-L family
ISU57_14195	COG0300	oxidoreductase activity
ISU57_14200	COG3118	belongs to the thioredoxin family
ISU57_14205	COG0330	HflC and HflK could
ISU57_14210	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISU57_14215	COG0789	Transcriptional regulator
ISU57_14220	COG2217	Heavy metal translocating P-type atpase
ISU57_14225	COG3735	TraB family
ISU57_14230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISU57_14245	COG2223	nitrite transmembrane transporter activity
ISU57_14250	COG4651	solute:proton antiporter activity
ISU57_14250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU57_14255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU57_14260	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU57_14280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU57_14320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU57_14340	COG0543	2 iron, 2 sulfur cluster binding
ISU57_14340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU57_14370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISU57_14380	COG2832	Protein of unknown function (DUF454)
ISU57_14395	COG1196	nuclear chromosome segregation
ISU57_14395	COG3264	Mechanosensitive ion channel
ISU57_14405	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISU57_14410	COG1309	transcriptional regulator
ISU57_14415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU57_14420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU57_14430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU57_14455	COG3695	enzyme binding
ISU57_14460	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISU57_14465	COG1946	Acyl-CoA thioesterase
ISU57_14470	COG0004	ammonium transporteR
ISU57_14475	COG0347	Belongs to the P(II) protein family
ISU57_14480	COG1132	(ABC) transporter
ISU57_14485	COG1132	(ABC) transporter
ISU57_14490	COG1522	sequence-specific DNA binding
ISU57_14505	COG4533	DNA binding
ISU57_14515	COG0824	Thioesterase
ISU57_14520	COG1555	photosystem II stabilization
ISU57_14525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU57_14530	COG0776	regulation of translation
ISU57_14535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISU57_14555	COG0271	Belongs to the BolA IbaG family
ISU57_14560	COG3056	Lipoprotein
ISU57_14565	COG2223	nitrite transmembrane transporter activity
ISU57_14575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISU57_14580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISU57_14585	COG1845	cytochrome c oxidase, subunit III
ISU57_14590	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISU57_14600	COG2814	Major facilitator Superfamily
ISU57_14610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISU57_14615	COG0693	protein deglycase activity
ISU57_14630	COG0142	geranyltranstransferase activity
ISU57_14655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISU57_14660	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISU57_14675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU57_14675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU57_14700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU57_14705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU57_14710	COG1862	Preprotein translocase
ISU57_14730	COG0450	alkyl hydroperoxide reductase
ISU57_14750	COG0366	Alpha amylase catalytic
ISU57_14770	COG5002	protein histidine kinase activity
ISU57_14775	COG0745	RESPONSE REGULATOR receiver
ISU57_14780	COG0420	3'-5' exonuclease activity
ISU57_14785	COG0419	ATPase involved in DNA repair
ISU57_14790	COG1940	carbohydrate kinase activity
ISU57_14815	COG2226	methyltransferase
ISU57_14865	COG0583	DNA-binding transcription factor activity
ISU57_14870	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU57_14890	COG1477	protein flavinylation
ISU57_14910	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU57_14915	COG1805	sodium ion transport
ISU57_14925	COG3034	peptidoglycan biosynthetic process
ISU57_14930	COG0121	glutamine amidotransferase
ISU57_14940	COG1960	acyl-CoA dehydrogenase activity
ISU57_14950	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
ISU57_14975	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU57_14990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU57_15000	COG0765	amino acid transport
ISU57_15035	COG2814	Major facilitator Superfamily
ISU57_15040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISU57_15050	COG1846	Transcriptional regulator
ISU57_15055	COG1566	PFAM secretion protein HlyD family protein
ISU57_15060	COG2814	Major facilitator Superfamily
ISU57_15065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU57_15070	COG3118	belongs to the thioredoxin family
ISU57_15075	COG3148	PFAM DTW domain containing protein
ISU57_15080	COG1042	CoA-binding domain protein
ISU57_15080	COG0045	succinate-CoA ligase (ADP-forming) activity
ISU57_15080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU57_15085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISU57_15090	COG5544	Lipoprotein
ISU57_15120	COG0542	response to heat
ISU57_15130	COG0564	pseudouridine synthase activity
ISU57_15135	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU57_15140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISU57_15170	COG0287	Prephenate dehydrogenase
ISU57_15170	COG1605	Chorismate mutase
ISU57_15175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU57_15180	COG3279	Response regulator of the LytR AlgR family
ISU57_15190	COG3137	Salt-induced outer membrane protein
ISU57_15220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISU57_15225	COG4137	Cytochrome C assembly protein
ISU57_15230	COG4536	flavin adenine dinucleotide binding
ISU57_15245	COG2918	glutathione biosynthetic process
ISU57_15250	COG1238	metal cluster binding
ISU57_15255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU57_15285	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISU57_15325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU57_15330	COG3958	Transketolase
ISU57_15335	COG3959	Transketolase, thiamine diphosphate binding domain
ISU57_15340	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_15345	COG1129	ABC transporter
ISU57_15355	COG1879	ABC-type sugar transport system periplasmic component
ISU57_15365	COG3783	Cytochrome b(562)
ISU57_15370	COG3038	cytochrome b561
ISU57_15375	COG3381	protein complex oligomerization
ISU57_15380	COG3302	dmso reductase anchor subunit
ISU57_15385	COG0437	4 iron, 4 sulfur cluster binding
ISU57_15390	COG0243	molybdopterin cofactor binding
ISU57_15395	COG0235	Class ii aldolase
ISU57_15400	COG1349	DNA-binding transcription factor activity
ISU57_15415	COG1129	ABC transporter
ISU57_15420	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_15425	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_15430	COG3623	hexulose-6-phosphate isomerase
ISU57_15435	COG1070	Carbohydrate kinase
ISU57_15440	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU57_15440	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU57_15450	COG0024	Methionine aminopeptidase
ISU57_15460	COG4771	TonB-dependent receptor
ISU57_15470	COG1858	cytochrome C peroxidase
ISU57_15475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_15495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISU57_15510	COG2376	Dihydroxyacetone kinase
ISU57_15515	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_15520	COG1063	alcohol dehydrogenase
ISU57_15525	COG0698	ribose 5-phosphate isomerase
ISU57_15535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISU57_15540	COG4942	peptidase
ISU57_15540	COG1388	LysM domain
ISU57_15580	COG0529	Catalyzes the synthesis of activated sulfate
ISU57_15635	COG0720	synthase
ISU57_15640	COG0602	queuosine metabolic process
ISU57_15660	COG3956	TIGRFAM MazG family protein
ISU57_15665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU57_15670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISU57_15680	COG3850	Histidine kinase
ISU57_15680	COG4999	Histidine kinase
ISU57_15680	COG2205	protein histidine kinase activity
ISU57_15680	COG3437	response regulator, receiver
ISU57_15685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU57_15705	COG2860	membrane
ISU57_15725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_15730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU57_15735	COG1120	ATPase activity
ISU57_15740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISU57_15745	COG1643	Atp-dependent helicase
ISU57_15750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISU57_15765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISU57_15770	COG0617	tRNA 3'-terminal CCA addition
ISU57_15775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISU57_15800	COG0842	Transport permease protein
ISU57_15805	COG1131	(ABC) transporter
ISU57_15810	COG0288	reversible hydration of carbon dioxide
ISU57_15815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISU57_15820	COG2132	Multicopper oxidase
ISU57_15840	COG0697	spore germination
ISU57_15850	COG1049	propionate catabolic process, 2-methylcitrate cycle
ISU57_15860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU57_15865	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU57_15870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISU57_15875	COG2186	Transcriptional regulator
ISU57_15880	COG1113	amino acid transport
ISU57_15885	COG3725	Membrane protein required for beta-lactamase induction
ISU57_15890	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU57_15900	COG4969	Belongs to the N-Me-Phe pilin family
ISU57_15905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU57_15910	COG1459	type II secretion system
ISU57_15960	COG0582	viral genome integration into host DNA
ISU57_15970	COG0795	lipopolysaccharide-transporting ATPase activity
ISU57_15975	COG0795	lipopolysaccharide-transporting ATPase activity
ISU57_15985	COG2927	DNA polymerase III (CHI subunit)
ISU57_15990	COG0525	valine-tRNA ligase activity
ISU57_16000	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ISU57_16010	COG2731	YhcH YjgK YiaL family protein
ISU57_16020	COG0601	transmembrane transport
ISU57_16025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU57_16030	COG0444	Belongs to the ABC transporter superfamily
ISU57_16035	COG4608	Belongs to the ABC transporter superfamily
ISU57_16050	COG2188	Transcriptional regulator
ISU57_16055	COG3624	Phosphonate C-P lyase system protein PhnG
ISU57_16060	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISU57_16065	COG3626	phosphonate metabolism
ISU57_16070	COG3627	carbon phosphorus lyase activity
ISU57_16075	COG4107	phosphonate C-P lyase system protein PhnK
ISU57_16080	COG4778	phosphonate C-P lyase system protein PhnL
ISU57_16085	COG3454	Phosphonate metabolism
ISU57_16090	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ISU57_16095	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISU57_16100	COG0702	epimerase
ISU57_16115	COG3842	ATPase activity
ISU57_16120	COG0395	ABC-type sugar transport system, permease component
ISU57_16125	COG1175	transmembrane transport
ISU57_16130	COG1653	transport
ISU57_16150	COG3153	acetyltransferase
ISU57_16155	COG3154	lipid carrier protein
ISU57_16160	COG0826	peptidase U32
ISU57_16165	COG0826	peptidase U32
ISU57_16175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU57_16185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISU57_16205	COG0513	Belongs to the DEAD box helicase family
ISU57_16250	COG0195	Participates in both transcription termination and antitermination
ISU57_16270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISU57_16280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISU57_16295	COG1534	Rna-binding protein
ISU57_16305	COG2027	D-alanyl-D-alanine carboxypeptidase
ISU57_16310	COG0745	RESPONSE REGULATOR receiver
ISU57_16315	COG0642	Histidine kinase
ISU57_16325	COG0697	spore germination
ISU57_16340	COG0142	geranyltranstransferase activity
ISU57_16350	COG3423	Transcriptional regulator
ISU57_16370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISU57_16375	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ISU57_16380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISU57_16385	COG2105	PFAM AIG2 family protein
ISU57_16390	COG2911	Protein conserved in bacteria
ISU57_16395	COG0729	surface antigen
ISU57_16405	COG1253	flavin adenine dinucleotide binding
ISU57_16415	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISU57_16425	COG0737	Belongs to the 5'-nucleotidase family
ISU57_16435	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU57_16440	COG3061	Opacity-associated protein A
ISU57_16460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISU57_16470	COG0360	Binds together with S18 to 16S ribosomal RNA
ISU57_16475	COG1073	alpha beta
ISU57_16495	COG3650	response to hydrogen peroxide
ISU57_16500	COG1960	acyl-CoA dehydrogenase activity
ISU57_16505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU57_16510	COG0557	exoribonuclease II activity
ISU57_16525	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISU57_16530	COG0330	HflC and HflK could
ISU57_16535	COG0330	HflC and HflK could
ISU57_16540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISU57_16560	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU57_16565	COG0802	atpase or kinase
ISU57_16570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISU57_16570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISU57_16575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISU57_16590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISU57_16605	COG1511	domain protein
ISU57_16605	COG3264	Mechanosensitive ion channel
ISU57_16620	COG1053	succinate dehydrogenase
ISU57_16625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISU57_16635	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ISU57_16680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISU57_16695	COG3383	formate dehydrogenase (NAD+) activity
ISU57_16700	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU57_16705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU57_16705	COG0493	'glutamate synthase
ISU57_16710	COG1309	transcriptional regulator
ISU57_16770	COG1454	alcohol dehydrogenase
ISU57_16780	COG0629	single-stranded DNA binding
ISU57_16785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISU57_16790	COG2315	Protein conserved in bacteria
ISU57_16795	COG1448	Aminotransferase
ISU57_16820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU57_16825	COG0735	belongs to the Fur family
ISU57_16835	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISU57_16875	COG3121	Chaperone
ISU57_16935	COG1358	cellular component organization or biogenesis
ISU57_16960	COG3721	Heme iron utilization protein
ISU57_16965	COG0702	epimerase
ISU57_16975	COG4771	TonB-dependent receptor
ISU57_16980	COG3720	iron ion transport
ISU57_16985	COG4558	Periplasmic binding protein
ISU57_16990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_17000	COG0626	cystathionine gamma-synthase activity
ISU57_17005	COG0814	amino acid
ISU57_17010	COG0583	DNA-binding transcription factor activity
ISU57_17015	COG0425	Belongs to the sulfur carrier protein TusA family
ISU57_17020	COG2391	methyltransferase activity
ISU57_17130	COG1301	dicarboxylic acid transport
ISU57_17140	COG3162	membrane
ISU57_17200	COG0151	Belongs to the GarS family
ISU57_17220	COG1515	deoxyribonuclease V activity
ISU57_17255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISU57_17310	COG0250	Participates in transcription elongation, termination and antitermination
ISU57_17370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISU57_17400	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISU57_17405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISU57_17420	COG1739	Uncharacterized protein family UPF0029
ISU57_17445	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISU57_17480	COG0805	protein transport
ISU57_17490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU57_17510	COG1322	Protein conserved in bacteria
ISU57_17515	COG0586	Pfam SNARE associated Golgi protein
ISU57_17520	COG1966	Carbon starvation protein
ISU57_17535	COG0412	Dienelactone hydrolase
ISU57_17545	COG0583	DNA-binding transcription factor activity
ISU57_17550	COG0697	spore germination
ISU57_17555	COG0679	Auxin Efflux Carrier
ISU57_17560	COG0584	glycerophosphoryl diester phosphodiesterase
ISU57_17620	COG0410	ABC transporter
ISU57_17630	COG4177	L-phenylalanine transmembrane transporter activity
ISU57_17640	COG0683	leucine binding
ISU57_17660	COG2177	Part of the ABC transporter FtsEX involved in
ISU57_17665	COG2884	Cell division ATP-binding protein ftsE
ISU57_17670	COG0552	protein localization to endoplasmic reticulum
ISU57_17670	COG0552	protein localization to endoplasmic reticulum
ISU57_17675	COG0742	ribosomal rna small subunit methyltransferase
ISU57_17680	COG3776	membrane
ISU57_17695	COG3714	YhhN family
ISU57_17710	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISU57_17720	COG0247	lactate metabolic process
ISU57_17730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU57_17735	COG0584	glycerophosphoryl diester phosphodiesterase
ISU57_17745	COG0561	phosphatase activity
ISU57_17750	COG2267	carboxylic ester hydrolase activity
ISU57_17755	COG1280	lysine exporter protein (LysE YggA)
ISU57_17760	COG1280	lysine exporter protein (LysE YggA)
ISU57_17765	COG0514	ATP-dependent DNA helicase (RecQ)
ISU57_17770	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ISU57_17775	COG2050	protein possibly involved in aromatic compounds catabolism
ISU57_17790	COG5564	TIM-barrel signal transduction protein
ISU57_17795	COG5441	Belongs to the UPF0261 family
ISU57_17805	COG0210	DNA helicase
ISU57_17810	COG1011	Hydrolase
ISU57_17815	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ISU57_17820	COG3159	Protein conserved in bacteria
ISU57_17840	COG3072	Adenylate cyclase
ISU57_17855	COG1587	Uroporphyrinogen-III synthase
ISU57_17860	COG2959	enzyme of heme biosynthesis
ISU57_17865	COG3071	HemY protein
ISU57_17895	COG1113	amino acid transport
ISU57_17915	COG2244	polysaccharide biosynthetic process
ISU57_17920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISU57_17925	COG0456	acetyltransferase
ISU57_17930	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISU57_17935	COG1088	dTDP-glucose 4,6-dehydratase activity
ISU57_17940	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISU57_17945	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISU57_17950	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU57_17955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISU57_17960	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISU57_17965	COG3118	belongs to the thioredoxin family
ISU57_17990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU57_18000	COG3328	transposase activity
ISU57_18010	COG3121	Chaperone
ISU57_18025	COG3121	Chaperone
ISU57_18060	COG0583	DNA-binding transcription factor activity
ISU57_18105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU57_18110	COG3978	acetolactate synthase activity
ISU57_18130	COG3085	chromosome segregation
ISU57_18140	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_18145	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_18150	COG1129	ABC transporter
ISU57_18155	COG1879	ABC-type sugar transport system periplasmic component
ISU57_18225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU57_18225	COG0678	peroxiredoxin activity
ISU57_18230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU57_18255	COG1629	transport
ISU57_18270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISU57_18295	COG0460	homoserine dehydrogenase
ISU57_18295	COG0527	aspartate kinase activity
ISU57_18310	COG4682	membrane
ISU57_18320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISU57_18325	COG1609	Transcriptional regulator
ISU57_18330	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU57_18345	COG1575	Belongs to the MenA family. Type 1 subfamily
ISU57_18455	COG3501	Rhs element vgr protein
ISU57_18500	COG3501	Rhs element vgr protein
ISU57_18510	COG3209	COG3209 Rhs family protein
ISU57_18530	COG0673	inositol 2-dehydrogenase activity
ISU57_18535	COG1917	Cupin 2, conserved barrel domain protein
ISU57_18535	COG2207	Transcriptional regulator
ISU57_18540	COG1869	D-ribose catabolic process
ISU57_18545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU57_18550	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISU57_18555	COG0431	NADPH-dependent FMN reductase
ISU57_18560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISU57_18570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU57_18585	COG3077	Addiction module antitoxin, RelB DinJ family
ISU57_18590	COG2252	PERMEase
ISU57_18595	COG0025	NhaP-type Na H and K H
ISU57_18605	COG1560	Kdo2-lipid A biosynthetic process
ISU57_18615	COG1129	ABC transporter
ISU57_18620	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_18630	COG1069	ribulokinase activity
ISU57_18640	COG0625	glutathione transferase activity
ISU57_18660	COG1278	Cold shock
ISU57_18665	COG1278	Cold shock
ISU57_18670	COG3133	Outer membrane lipoprotein
ISU57_18675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU57_18685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU57_18715	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISU57_18720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU57_18730	COG4145	pantothenate transmembrane transporter activity
ISU57_18735	COG3924	membrane
ISU57_18745	COG0439	Biotin carboxylase
ISU57_18750	COG0511	ligase activity, forming carbon-carbon bonds
ISU57_18765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISU57_18770	COG0604	alcohol dehydrogenase
ISU57_18775	COG2199	diguanylate cyclase activity
ISU57_18775	COG2200	EAL domain
ISU57_18780	COG1077	Cell shape determining protein MreB Mrl
ISU57_18785	COG1792	Involved in formation and maintenance of cell shape
ISU57_18790	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISU57_18795	COG0424	maF-like protein
ISU57_18800	COG1530	ribonuclease E activity
ISU57_18805	COG3164	Protein of unknown function
ISU57_18810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU57_18815	COG0312	modulator of DNA gyrase
ISU57_18865	COG0583	DNA-binding transcription factor activity
ISU57_18895	COG2732	(Barnase) inhibitor
ISU57_18905	COG0312	modulator of DNA gyrase
ISU57_18915	COG3783	Cytochrome b(562)
ISU57_18920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU57_18925	COG0366	Alpha amylase catalytic
ISU57_18930	COG1263	PTS System
ISU57_18930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU57_18935	COG1609	Transcriptional regulator
ISU57_18960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_18980	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISU57_18985	COG1137	ATPase activity
ISU57_18990	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISU57_18995	COG3117	lipopolysaccharide transmembrane transporter activity
ISU57_19000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISU57_19005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISU57_19005	COG0517	IMP dehydrogenase activity
ISU57_19015	COG1127	ABC transporter
ISU57_19020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISU57_19025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU57_19030	COG2854	intermembrane phospholipid transfer
ISU57_19035	COG3113	response to antibiotic
ISU57_19040	COG5007	Belongs to the BolA IbaG family
ISU57_19050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU57_19060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU57_19065	COG3105	Protein conserved in bacteria
ISU57_19070	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISU57_19090	COG0625	glutathione transferase activity
ISU57_19095	COG2969	positive regulation of protein catabolic process
ISU57_19105	COG0493	'glutamate synthase
ISU57_19110	COG0070	glutamate synthase
ISU57_19110	COG0069	glutamate synthase activity
ISU57_19110	COG0067	glutamate synthase
ISU57_19120	COG0784	Response regulator, receiver
ISU57_19120	COG2198	Histidine kinase
ISU57_19120	COG5002	protein histidine kinase activity
ISU57_19125	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISU57_19135	COG2823	Periplasmic or secreted lipoprotein
ISU57_19155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISU57_19165	COG1741	Belongs to the pirin family
ISU57_19170	COG0583	DNA-binding transcription factor activity
ISU57_19190	COG0456	acetyltransferase
ISU57_19195	COG2982	Protein involved in outer membrane biogenesis
ISU57_19200	COG2233	PERMEase
ISU57_19205	COG0786	glutamate:sodium symporter activity
ISU57_19215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISU57_19220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU57_19225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU57_19245	COG2860	membrane
ISU57_19250	COG1561	YicC-like family, N-terminal region
ISU57_19275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISU57_19310	COG1519	Transferase
ISU57_19315	COG0859	PFAM glycosyl transferase family 9
ISU57_19320	COG0859	PFAM glycosyl transferase family 9
ISU57_19330	COG0156	8-amino-7-oxononanoate synthase activity
ISU57_19345	COG4942	peptidase
ISU57_19355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU57_19360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU57_19375	COG1045	serine acetyltransferase
ISU57_19380	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISU57_19385	COG2169	Transcriptional regulator
ISU57_19385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU57_19390	COG2205	protein histidine kinase activity
ISU57_19395	COG0745	RESPONSE REGULATOR receiver
ISU57_19400	COG3678	ATP-independent chaperone mediated protein folding
ISU57_19425	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISU57_19435	COG0471	metal ion transport
ISU57_19440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISU57_19445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISU57_19450	COG0583	DNA-binding transcription factor activity
ISU57_19465	COG3152	Membrane
ISU57_19475	COG1494	fructose-1,6-bisphosphatase
ISU57_19480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU57_19485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISU57_19530	COG0560	Phosphoserine phosphatase
ISU57_19535	COG3726	membrane protein affecting hemolysin expression
ISU57_19565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU57_19570	COG0084	hydrolase, TatD family'
ISU57_19575	COG4667	esterase of the alpha-beta hydrolase superfamily
ISU57_19585	COG2823	Periplasmic or secreted lipoprotein
ISU57_19595	COG0456	acetyltransferase
ISU57_19600	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISU57_19640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU57_19645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU57_19660	COG0859	PFAM glycosyl transferase family 9
ISU57_19665	COG1070	Carbohydrate kinase
ISU57_19715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_19715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_19715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU57_19720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU57_19725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU57_19730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU57_19735	COG2207	Transcriptional regulator
ISU57_19745	COG4269	membrane
ISU57_19800	COG1401	restriction endodeoxyribonuclease activity
ISU57_19825	COG1011	Hydrolase
ISU57_19835	COG0174	glutamine synthetase
ISU57_19840	COG3852	Histidine kinase
ISU57_19850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU57_19875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU57_19875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU57_19880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU57_19885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISU57_19890	COG3084	Protein conserved in bacteria
ISU57_19900	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISU57_19905	COG3328	transposase activity
ISU57_19930	COG2186	Transcriptional regulator
ISU57_19935	COG0477	Major facilitator Superfamily
ISU57_19950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU57_19980	COG1522	sequence-specific DNA binding
ISU57_19985	COG0716	FMN binding
ISU57_20000	COG3312	ion transport
ISU57_20055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISU57_20060	COG0573	inorganic phosphate transmembrane transporter activity
ISU57_20065	COG0581	inorganic phosphate transmembrane transporter activity
ISU57_20075	COG0704	Plays a role in the regulation of phosphate uptake
ISU57_20085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_20090	COG0765	amino acid transport
ISU57_20095	COG0765	amino acid transport
ISU57_20100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU57_20110	COG2252	PERMEase
ISU57_20140	COG0706	membrane insertase activity
ISU57_20155	COG0230	Belongs to the bacterial ribosomal protein bL34 family