locus-tag	class	description
ISU58_00010	COG0592	DNA-directed DNA polymerase activity
ISU58_00025	COG0187	DNA topoisomerase II activity
ISU58_00030	COG0561	phosphatase activity
ISU58_00055	COG1349	DNA-binding transcription factor activity
ISU58_00075	COG0058	SHG alpha-glucan phosphorylase activity
ISU58_00080	COG0058	SHG alpha-glucan phosphorylase activity
ISU58_00085	COG1640	4-alpha-glucanotransferase
ISU58_00120	COG1918	ferrous iron import across plasma membrane
ISU58_00125	COG2183	response to ionizing radiation
ISU58_00130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU58_00155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISU58_00160	COG1011	Hydrolase
ISU58_00170	COG0494	nUDIX hydrolase
ISU58_00175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISU58_00200	COG4796	Type ii and iii secretion system protein
ISU58_00225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISU58_00230	COG0546	phosphoglycolate phosphatase activity
ISU58_00235	COG0180	Tryptophanyl-tRNA synthetase
ISU58_00255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISU58_00260	COG0402	S-adenosylhomocysteine deaminase activity
ISU58_00280	COG1486	melibiose metabolic process
ISU58_00285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU58_00290	COG0433	COG0433 Predicted ATPase
ISU58_00305	COG1289	transmembrane transporter activity
ISU58_00315	COG1765	OsmC-like protein
ISU58_00325	COG3954	Phosphoribulokinase
ISU58_00335	COG0429	hydrolase of the alpha beta-hydrolase fold
ISU58_00345	COG4521	taurine ABC transporter
ISU58_00355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU58_00360	COG2175	clavaminate synthase activity
ISU58_00370	COG1216	Glycosyl transferase, family 2
ISU58_00390	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISU58_00395	COG1047	Peptidyl-prolyl cis-trans
ISU58_00405	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU58_00410	COG2964	Protein conserved in bacteria
ISU58_00430	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ISU58_00435	COG0049	tRNA binding
ISU58_00465	COG0051	transcription antitermination factor activity, RNA binding
ISU58_00480	COG0089	rRNA binding
ISU58_00490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISU58_00500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISU58_00505	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISU58_00515	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISU58_00520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ISU58_00560	COG1841	ribosomal large subunit assembly
ISU58_00570	COG0201	protein transport
ISU58_00575	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU58_00590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISU58_00605	COG0789	Transcriptional regulator
ISU58_00610	COG3036	rescue of stalled ribosome
ISU58_00640	COG0758	DNA mediated transformation
ISU58_00650	COG0551	DNA topoisomerase type I activity
ISU58_00665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISU58_00685	COG2197	response regulator
ISU58_00690	COG2194	sulfuric ester hydrolase activity
ISU58_00705	COG2986	histidine ammonia-lyase
ISU58_00735	COG4607	ABC-type enterochelin transport system periplasmic component
ISU58_00745	COG4605	iron ion homeostasis
ISU58_00750	COG4604	ABC transporter, ATP-binding protein
ISU58_00795	COG0582	viral genome integration into host DNA
ISU58_00805	COG1609	Transcriptional regulator
ISU58_00805	COG2207	Transcriptional regulator
ISU58_00810	COG4214	carbohydrate transport
ISU58_00820	COG4213	ABC transporter substrate-binding protein
ISU58_00830	COG1070	Carbohydrate kinase
ISU58_00840	COG3121	Chaperone
ISU58_00855	COG3274	enterobacterial common antigen metabolic process
ISU58_00900	COG3276	selenocysteine insertion sequence binding
ISU58_00915	COG2864	formate dehydrogenase
ISU58_00920	COG0437	4 iron, 4 sulfur cluster binding
ISU58_00935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISU58_00960	COG3722	fumarate hydratase activity
ISU58_00970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU58_00970	COG2213	PTS system mannitol-specific
ISU58_00995	COG2818	Glycosylase
ISU58_01005	COG2885	chlorophyll binding
ISU58_01020	COG0366	Alpha amylase catalytic
ISU58_01030	COG3977	Valine--pyruvate aminotransferase
ISU58_01050	COG5645	(Lipo)protein
ISU58_01060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISU58_01065	COG2423	ornithine cyclodeaminase activity
ISU58_01090	COG0513	Belongs to the DEAD box helicase family
ISU58_01110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISU58_01120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU58_01130	COG0826	peptidase U32
ISU58_01135	COG0826	peptidase U32
ISU58_01140	COG3154	lipid carrier protein
ISU58_01145	COG3153	acetyltransferase
ISU58_01165	COG1653	transport
ISU58_01170	COG1175	transmembrane transport
ISU58_01175	COG0395	ABC-type sugar transport system, permease component
ISU58_01180	COG3842	ATPase activity
ISU58_01195	COG0702	epimerase
ISU58_01200	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISU58_01205	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ISU58_01210	COG3454	Phosphonate metabolism
ISU58_01215	COG4778	phosphonate C-P lyase system protein PhnL
ISU58_01220	COG4107	phosphonate C-P lyase system protein PhnK
ISU58_01225	COG3627	carbon phosphorus lyase activity
ISU58_01230	COG3626	phosphonate metabolism
ISU58_01235	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISU58_01240	COG3624	Phosphonate C-P lyase system protein PhnG
ISU58_01245	COG2188	Transcriptional regulator
ISU58_01260	COG4608	Belongs to the ABC transporter superfamily
ISU58_01265	COG0444	Belongs to the ABC transporter superfamily
ISU58_01270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU58_01275	COG0601	transmembrane transport
ISU58_01285	COG2731	YhcH YjgK YiaL family protein
ISU58_01295	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ISU58_01305	COG0525	valine-tRNA ligase activity
ISU58_01310	COG2927	DNA polymerase III (CHI subunit)
ISU58_01320	COG0795	lipopolysaccharide-transporting ATPase activity
ISU58_01325	COG0795	lipopolysaccharide-transporting ATPase activity
ISU58_01335	COG0582	viral genome integration into host DNA
ISU58_01385	COG1459	type II secretion system
ISU58_01390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU58_01395	COG4969	Belongs to the N-Me-Phe pilin family
ISU58_01405	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU58_01410	COG3725	Membrane protein required for beta-lactamase induction
ISU58_01415	COG1113	amino acid transport
ISU58_01420	COG2186	Transcriptional regulator
ISU58_01425	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISU58_01430	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU58_01435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU58_01445	COG1049	propionate catabolic process, 2-methylcitrate cycle
ISU58_01455	COG0697	spore germination
ISU58_01475	COG2132	Multicopper oxidase
ISU58_01480	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISU58_01485	COG0288	reversible hydration of carbon dioxide
ISU58_01490	COG1131	(ABC) transporter
ISU58_01495	COG0842	Transport permease protein
ISU58_01520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISU58_01525	COG0617	tRNA 3'-terminal CCA addition
ISU58_01530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISU58_01545	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISU58_01550	COG1643	Atp-dependent helicase
ISU58_01555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISU58_01560	COG1120	ATPase activity
ISU58_01565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU58_01570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_01590	COG2860	membrane
ISU58_01610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU58_01615	COG2205	protein histidine kinase activity
ISU58_01615	COG3437	response regulator, receiver
ISU58_01615	COG3850	Histidine kinase
ISU58_01615	COG4999	Histidine kinase
ISU58_01625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISU58_01630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU58_01635	COG3956	TIGRFAM MazG family protein
ISU58_01655	COG0602	queuosine metabolic process
ISU58_01660	COG0720	synthase
ISU58_01715	COG0529	Catalyzes the synthesis of activated sulfate
ISU58_01755	COG1388	LysM domain
ISU58_01755	COG4942	peptidase
ISU58_01770	COG0698	ribose 5-phosphate isomerase
ISU58_01775	COG1063	alcohol dehydrogenase
ISU58_01780	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_01785	COG2376	Dihydroxyacetone kinase
ISU58_01800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISU58_01820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_01825	COG1858	cytochrome C peroxidase
ISU58_01835	COG4771	TonB-dependent receptor
ISU58_01845	COG0024	Methionine aminopeptidase
ISU58_01855	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU58_01855	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU58_01860	COG1070	Carbohydrate kinase
ISU58_01865	COG3623	hexulose-6-phosphate isomerase
ISU58_01870	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_01875	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_01880	COG1129	ABC transporter
ISU58_01895	COG1349	DNA-binding transcription factor activity
ISU58_01900	COG0235	Class ii aldolase
ISU58_01905	COG0243	molybdopterin cofactor binding
ISU58_01910	COG0437	4 iron, 4 sulfur cluster binding
ISU58_01915	COG3302	dmso reductase anchor subunit
ISU58_01920	COG3381	protein complex oligomerization
ISU58_01925	COG3038	cytochrome b561
ISU58_01930	COG3783	Cytochrome b(562)
ISU58_01940	COG1879	ABC-type sugar transport system periplasmic component
ISU58_01950	COG1129	ABC transporter
ISU58_01955	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_01960	COG3959	Transketolase, thiamine diphosphate binding domain
ISU58_01965	COG3958	Transketolase
ISU58_01970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU58_02010	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISU58_02040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU58_02045	COG1238	metal cluster binding
ISU58_02050	COG2918	glutathione biosynthetic process
ISU58_02065	COG4536	flavin adenine dinucleotide binding
ISU58_02070	COG4137	Cytochrome C assembly protein
ISU58_02075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISU58_02105	COG3137	Salt-induced outer membrane protein
ISU58_02115	COG3279	Response regulator of the LytR AlgR family
ISU58_02120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU58_02125	COG1605	Chorismate mutase
ISU58_02125	COG0287	Prephenate dehydrogenase
ISU58_02155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISU58_02160	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU58_02165	COG0564	pseudouridine synthase activity
ISU58_02175	COG0542	response to heat
ISU58_02205	COG5544	Lipoprotein
ISU58_02210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISU58_02215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU58_02215	COG0045	succinate-CoA ligase (ADP-forming) activity
ISU58_02215	COG1042	CoA-binding domain protein
ISU58_02220	COG3148	PFAM DTW domain containing protein
ISU58_02225	COG3118	belongs to the thioredoxin family
ISU58_02230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU58_02235	COG2814	Major facilitator Superfamily
ISU58_02240	COG1566	PFAM secretion protein HlyD family protein
ISU58_02245	COG1846	Transcriptional regulator
ISU58_02255	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISU58_02260	COG2814	Major facilitator Superfamily
ISU58_02295	COG0765	amino acid transport
ISU58_02305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU58_02320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU58_02345	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
ISU58_02355	COG1960	acyl-CoA dehydrogenase activity
ISU58_02365	COG0121	glutamine amidotransferase
ISU58_02370	COG3034	peptidoglycan biosynthetic process
ISU58_02380	COG1805	sodium ion transport
ISU58_02385	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU58_02405	COG1477	protein flavinylation
ISU58_02425	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU58_02430	COG0583	DNA-binding transcription factor activity
ISU58_02480	COG2226	methyltransferase
ISU58_02505	COG1940	carbohydrate kinase activity
ISU58_02510	COG0419	ATPase involved in DNA repair
ISU58_02515	COG0420	3'-5' exonuclease activity
ISU58_02520	COG0745	RESPONSE REGULATOR receiver
ISU58_02525	COG5002	protein histidine kinase activity
ISU58_02545	COG0366	Alpha amylase catalytic
ISU58_02565	COG0450	alkyl hydroperoxide reductase
ISU58_02585	COG1862	Preprotein translocase
ISU58_02590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU58_02595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU58_02625	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU58_02625	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU58_02640	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISU58_02645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISU58_02660	COG0142	geranyltranstransferase activity
ISU58_02675	COG0693	protein deglycase activity
ISU58_02680	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISU58_02690	COG2814	Major facilitator Superfamily
ISU58_02700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISU58_02705	COG1845	cytochrome c oxidase, subunit III
ISU58_02710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISU58_02715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISU58_02725	COG2223	nitrite transmembrane transporter activity
ISU58_02730	COG3056	Lipoprotein
ISU58_02735	COG0271	Belongs to the BolA IbaG family
ISU58_02755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISU58_02760	COG0776	regulation of translation
ISU58_02765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU58_02770	COG1555	photosystem II stabilization
ISU58_02775	COG0824	Thioesterase
ISU58_02810	COG1522	sequence-specific DNA binding
ISU58_02815	COG1132	(ABC) transporter
ISU58_02820	COG1132	(ABC) transporter
ISU58_02825	COG0347	Belongs to the P(II) protein family
ISU58_02830	COG0004	ammonium transporteR
ISU58_02835	COG1946	Acyl-CoA thioesterase
ISU58_02840	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISU58_02845	COG3695	enzyme binding
ISU58_02870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU58_02880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU58_02885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU58_02890	COG1309	transcriptional regulator
ISU58_02895	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISU58_02900	COG1196	nuclear chromosome segregation
ISU58_02900	COG3264	Mechanosensitive ion channel
ISU58_02915	COG2832	Protein of unknown function (DUF454)
ISU58_02925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISU58_02955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU58_02955	COG0543	2 iron, 2 sulfur cluster binding
ISU58_02975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU58_03015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU58_03035	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU58_03040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU58_03045	COG4651	solute:proton antiporter activity
ISU58_03045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU58_03050	COG2223	nitrite transmembrane transporter activity
ISU58_03065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISU58_03070	COG3735	TraB family
ISU58_03075	COG2217	Heavy metal translocating P-type atpase
ISU58_03080	COG0789	Transcriptional regulator
ISU58_03085	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISU58_03090	COG0330	HflC and HflK could
ISU58_03095	COG3118	belongs to the thioredoxin family
ISU58_03100	COG0300	oxidoreductase activity
ISU58_03105	COG2755	lipolytic protein G-D-S-L family
ISU58_03110	COG4181	ATPase activity
ISU58_03115	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISU58_03120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISU58_03125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISU58_03135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU58_03150	COG2501	S4 domain
ISU58_03185	COG0582	viral genome integration into host DNA
ISU58_03195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISU58_03200	COG4589	Belongs to the CDS family
ISU58_03210	COG2267	carboxylic ester hydrolase activity
ISU58_03215	COG0671	phosphoesterase, PA-phosphatase related
ISU58_03215	COG2453	phosphatase
ISU58_03245	COG0667	Aldo Keto reductase
ISU58_03250	COG0656	L-ascorbic acid biosynthetic process
ISU58_03260	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU58_03275	COG3328	transposase activity
ISU58_03330	COG3423	Transcriptional regulator
ISU58_03335	COG4953	penicillin-binding protein 1C
ISU58_03345	COG2373	Large extracellular alpha-helical protein
ISU58_03365	COG3962	Belongs to the TPP enzyme family
ISU58_03380	COG1129	ABC transporter
ISU58_03385	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_03390	COG0673	inositol 2-dehydrogenase activity
ISU58_03395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU58_03405	COG3718	enzyme involved in inositol metabolism
ISU58_03415	COG5265	(ABC) transporter
ISU58_03440	COG2197	response regulator
ISU58_03445	COG1278	Cold shock
ISU58_03455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU58_03460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU58_03480	COG1686	Belongs to the peptidase S11 family
ISU58_03485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU58_03490	COG0772	Belongs to the SEDS family
ISU58_03495	COG0768	penicillin binding
ISU58_03505	COG0799	negative regulation of ribosome biogenesis
ISU58_03515	COG1466	dna polymerase III delta subunit
ISU58_03530	COG2888	peptidyl-tyrosine sulfation
ISU58_03535	COG1126	abc transporter atp-binding protein
ISU58_03540	COG0765	amino acid transport
ISU58_03545	COG0765	amino acid transport
ISU58_03555	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ISU58_03560	COG4535	Mg2 and Co2 transporter CorC
ISU58_03570	COG1702	phosphate starvation-inducible protein PhoH
ISU58_03575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISU58_03580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU58_03615	COG0367	asparagine synthase
ISU58_03620	COG0647	UMP catabolic process
ISU58_03625	COG1940	carbohydrate kinase activity
ISU58_03625	COG1846	Transcriptional regulator
ISU58_03630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISU58_03640	COG2190	(PTS) system
ISU58_03640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU58_03640	COG1263	PTS System
ISU58_03665	COG0735	belongs to the Fur family
ISU58_03680	COG0596	Alpha beta hydrolase
ISU58_03690	COG0582	viral genome integration into host DNA
ISU58_03725	COG2113	Glycine betaine
ISU58_03730	COG4176	ABC-type proline glycine betaine transport system permease component
ISU58_03735	COG4175	Glycine betaine
ISU58_03740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISU58_03780	COG1278	Cold shock
ISU58_03785	COG0747	negative chemotaxis
ISU58_03795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU58_03800	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ISU58_03805	COG1124	(ABC) transporter
ISU58_03810	COG0831	urea catabolic process
ISU58_03835	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISU58_03845	COG4413	Urea transporter
ISU58_03850	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU58_03860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU58_03870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU58_03880	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU58_03885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU58_03890	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISU58_03895	COG1917	Cupin 2, conserved barrel domain protein
ISU58_03895	COG2169	Transcriptional regulator
ISU58_03910	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ISU58_03915	COG0033	Phosphoglucomutase
ISU58_03930	COG0745	RESPONSE REGULATOR receiver
ISU58_03935	COG2205	protein histidine kinase activity
ISU58_03970	COG3272	Protein of unknown function (DUF1722)
ISU58_03980	COG5212	phosphodiesterase
ISU58_03985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ISU58_04000	COG1984	allophanate hydrolase subunit 2
ISU58_04045	COG0513	Belongs to the DEAD box helicase family
ISU58_04055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISU58_04070	COG3026	antisigma factor binding
ISU58_04075	COG3086	response to oxidative stress
ISU58_04110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISU58_04125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU58_04130	COG1737	Transcriptional regulator
ISU58_04140	COG0560	Phosphoserine phosphatase
ISU58_04185	COG2205	protein histidine kinase activity
ISU58_04190	COG3170	Tfp pilus assembly protein FimV
ISU58_04195	COG2204	response regulator
ISU58_04200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISU58_04200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU58_04205	COG0347	Belongs to the P(II) protein family
ISU58_04230	COG1017	nitric oxide dioxygenase activity
ISU58_04230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU58_04250	COG2814	Major facilitator Superfamily
ISU58_04255	COG3711	transcriptional antiterminator
ISU58_04260	COG3683	transport system, periplasmic component
ISU58_04265	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU58_04285	COG1104	cysteine desulfurase activity
ISU58_04290	COG0822	iron-sulfur transferase activity
ISU58_04310	COG0633	Ferredoxin
ISU58_04315	COG2975	iron-sulfur cluster assembly
ISU58_04340	COG3468	outer membrane autotransporter barrel domain protein
ISU58_04345	COG3468	outer membrane autotransporter barrel domain protein
ISU58_04385	COG2976	Protein conserved in bacteria
ISU58_04390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU58_04405	COG1645	bacterial-type flagellum-dependent swarming motility
ISU58_04415	COG0517	IMP dehydrogenase activity
ISU58_04415	COG0516	GMP reductase activity
ISU58_04460	COG3328	transposase activity
ISU58_04475	COG0351	phosphomethylpyrimidine kinase
ISU58_04500	COG0826	peptidase U32
ISU58_04505	COG3422	double-strand break repair
ISU58_04510	COG0745	RESPONSE REGULATOR receiver
ISU58_04540	COG3842	ATPase activity
ISU58_04550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISU58_04560	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU58_04565	COG1177	transmembrane transport
ISU58_04570	COG0443	Heat shock 70 kDa protein
ISU58_04575	COG2239	Acts as a magnesium transporter
ISU58_04590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISU58_04600	COG0581	inorganic phosphate transmembrane transporter activity
ISU58_04615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU58_04620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISU58_04645	COG1393	Belongs to the ArsC family
ISU58_04650	COG4783	chaperone-mediated protein folding
ISU58_04655	COG0628	permease
ISU58_04665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISU58_04670	COG2716	regulation of RNA biosynthetic process
ISU58_04680	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISU58_04695	COG2321	neutral zinc metallopeptidase
ISU58_04715	COG1876	peptidase activity
ISU58_04725	COG1393	Belongs to the ArsC family
ISU58_04740	COG1175	transmembrane transport
ISU58_04745	COG3842	ATPase activity
ISU58_04755	COG3119	arylsulfatase activity
ISU58_04760	COG0641	radical SAM
ISU58_04765	COG1988	membrane-bound metal-dependent
ISU58_04775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU58_04785	COG2197	response regulator
ISU58_04790	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU58_04790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU58_04795	COG3062	negative regulation of establishment of protein localization
ISU58_04805	COG3043	anaerobic respiration
ISU58_04810	COG3005	denitrification pathway
ISU58_04860	COG2837	iron assimilation
ISU58_04865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISU58_04875	COG4886	Leucine-rich repeat (LRR) protein
ISU58_04885	COG2731	YhcH YjgK YiaL family protein
ISU58_04890	COG1737	Transcriptional regulator
ISU58_04900	COG4150	thiosulfate binding
ISU58_04905	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISU58_04910	COG4208	sulfate ABC transporter
ISU58_04915	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISU58_04930	COG0745	RESPONSE REGULATOR receiver
ISU58_04935	COG5002	protein histidine kinase activity
ISU58_04935	COG3850	Histidine kinase
ISU58_04945	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISU58_04965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISU58_04980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU58_04985	COG0745	RESPONSE REGULATOR receiver
ISU58_04990	COG2205	protein histidine kinase activity
ISU58_05010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU58_05020	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ISU58_05035	COG3530	Putative quorum-sensing-regulated virulence factor
ISU58_05100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU58_05115	COG0667	Aldo Keto reductase
ISU58_05140	COG0436	Aminotransferase
ISU58_05145	COG3038	cytochrome b561
ISU58_05175	COG3381	protein complex oligomerization
ISU58_05180	COG3302	dmso reductase anchor subunit
ISU58_05185	COG0437	4 iron, 4 sulfur cluster binding
ISU58_05190	COG0243	molybdopterin cofactor binding
ISU58_05225	COG2951	lytic endotransglycosylase activity
ISU58_05285	COG3121	Chaperone
ISU58_05290	COG3188	usher protein
ISU58_05295	COG3328	transposase activity
ISU58_05300	COG3188	usher protein
ISU58_05390	COG2824	Alkylphosphonate utilization operon protein PhnA
ISU58_05400	COG1704	LemA family
ISU58_05420	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU58_05425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU58_05430	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU58_05440	COG1138	Cytochrome C-type biogenesis protein
ISU58_05450	COG3088	subunit of a heme lyase
ISU58_05450	COG4235	cytochrome complex assembly
ISU58_05455	COG3088	subunit of a heme lyase
ISU58_05455	COG4235	cytochrome complex assembly
ISU58_05470	COG3691	Protein conserved in bacteria
ISU58_05485	COG2062	phosphohistidine phosphatase, SixA
ISU58_05495	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU58_05510	COG0730	response to heat
ISU58_05515	COG3101	peptidyl-lysine hydroxylation
ISU58_05530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU58_05535	COG1794	racemase activity, acting on amino acids and derivatives
ISU58_05550	COG0697	spore germination
ISU58_05565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU58_05575	COG0586	Pfam SNARE associated Golgi protein
ISU58_05585	COG0285	dihydrofolate synthase activity
ISU58_05590	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISU58_05595	COG1286	toxin biosynthetic process
ISU58_05600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISU58_05610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_05615	COG4215	(ABC) transporter
ISU58_05620	COG4160	amino acid transport
ISU58_05625	COG4598	ABC transporter
ISU58_05630	COG1090	epimerase
ISU58_05640	COG0622	Phosphoesterase
ISU58_05645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISU58_05650	COG3037	sugar-specific permease SgaT UlaA
ISU58_05655	COG3328	transposase activity
ISU58_05670	COG1609	Transcriptional regulator
ISU58_05675	COG0857	belongs to the CobB CobQ family
ISU58_05675	COG0280	phosphate acetyltransferase
ISU58_05695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU58_05700	COG0490	domain, Protein
ISU58_05700	COG0471	metal ion transport
ISU58_05715	COG0436	Aminotransferase
ISU58_05720	COG0583	DNA-binding transcription factor activity
ISU58_05730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU58_05750	COG1034	ATP synthesis coupled electron transport
ISU58_05765	COG0839	Belongs to the complex I subunit 6 family
ISU58_05775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISU58_05780	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU58_05800	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_05805	COG3265	gluconokinase activity
ISU58_05820	COG1649	PFAM Uncharacterised BCR, COG1649
ISU58_05825	COG1609	Transcriptional regulator
ISU58_05830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU58_05845	COG0129	dihydroxy-acid dehydratase activity
ISU58_05850	COG4575	ribosome binding
ISU58_05860	COG1169	isochorismate synthase
ISU58_05875	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ISU58_05890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISU58_05925	COG1126	abc transporter atp-binding protein
ISU58_05930	COG0765	amino acid transport
ISU58_05935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_05965	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISU58_05985	COG1063	alcohol dehydrogenase
ISU58_05990	COG1879	ABC-type sugar transport system periplasmic component
ISU58_05995	COG1129	ABC transporter
ISU58_06000	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_06005	COG1609	Transcriptional regulator
ISU58_06010	COG0583	DNA-binding transcription factor activity
ISU58_06015	COG0473	3-isopropylmalate dehydrogenase activity
ISU58_06025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISU58_06035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU58_06040	COG2831	hemolysin activation secretion protein
ISU58_06045	COG3210	domain, Protein
ISU58_06085	COG3210	domain, Protein
ISU58_06095	COG3842	ATPase activity
ISU58_06105	COG1609	Transcriptional regulator
ISU58_06120	COG0395	ABC-type sugar transport system, permease component
ISU58_06125	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ISU58_06150	COG0668	transmembrane transport
ISU58_06155	COG1518	maintenance of DNA repeat elements
ISU58_06160	COG1203	CRISPR-associated helicase, Cas3
ISU58_06185	COG0667	Aldo Keto reductase
ISU58_06195	COG0477	Major facilitator Superfamily
ISU58_06205	COG0583	DNA-binding transcription factor activity
ISU58_06210	COG2771	luxR family
ISU58_06215	COG3916	Acyl-homoserine-lactone synthase
ISU58_06235	COG0628	permease
ISU58_06255	COG3328	transposase activity
ISU58_06265	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISU58_06285	COG3328	transposase activity
ISU58_06290	COG1530	ribonuclease E activity
ISU58_06295	COG0564	pseudouridine synthase activity
ISU58_06300	COG0424	maF-like protein
ISU58_06305	COG1399	metal-binding, possibly nucleic acid-binding protein
ISU58_06310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISU58_06340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU58_06350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU58_06355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISU58_06365	COG0470	DNA polymerase III
ISU58_06370	COG0084	hydrolase, TatD family'
ISU58_06375	COG1263	PTS System
ISU58_06375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU58_06400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISU58_06405	COG0537	adenosine 5'-monophosphoramidase activity
ISU58_06410	COG5633	Lipoprotein
ISU58_06425	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU58_06435	COG1252	NADH dehydrogenase
ISU58_06450	COG3328	transposase activity
ISU58_06455	COG3134	Outer membrane lipoprotein
ISU58_06460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISU58_06465	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU58_06475	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU58_06480	COG1940	carbohydrate kinase activity
ISU58_06500	COG2850	peptidyl-arginine hydroxylation
ISU58_06510	COG0745	RESPONSE REGULATOR receiver
ISU58_06520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISU58_06540	COG1187	pseudouridine synthase activity
ISU58_06545	COG0538	isocitrate dehydrogenase activity
ISU58_06560	COG0840	transmembrane signaling receptor activity
ISU58_06565	COG0702	epimerase
ISU58_06570	COG1733	regulation of RNA biosynthetic process
ISU58_06595	COG1522	sequence-specific DNA binding
ISU58_06610	COG3321	synthase
ISU58_06610	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_06610	COG0604	alcohol dehydrogenase
ISU58_06635	COG1285	pathogenesis
ISU58_06660	COG1360	Flagellar Motor Protein
ISU58_06665	COG2198	Histidine kinase
ISU58_06665	COG0643	Histidine kinase
ISU58_06670	COG0835	chemotaxis
ISU58_06675	COG2271	Major facilitator Superfamily
ISU58_06680	COG0251	oxidation-reduction process
ISU58_06690	COG2964	Protein conserved in bacteria
ISU58_06710	COG0840	transmembrane signaling receptor activity
ISU58_06715	COG0840	transmembrane signaling receptor activity
ISU58_06720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ISU58_06730	COG0745	RESPONSE REGULATOR receiver
ISU58_06735	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISU58_06740	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU58_06750	COG5295	Hep Hag repeat protein
ISU58_06760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISU58_06815	COG3121	Chaperone
ISU58_06835	COG3008	intermembrane lipid transfer
ISU58_06840	COG2995	paraquat-inducible protein a
ISU58_06845	COG1956	GAF domain-containing protein
ISU58_06855	COG0793	Belongs to the peptidase S41A family
ISU58_06865	COG3539	Fimbrial protein
ISU58_06870	COG3121	Chaperone
ISU58_06885	COG3121	Chaperone
ISU58_06890	COG2814	Major facilitator Superfamily
ISU58_06895	COG0823	Involved in the tonB-independent uptake of proteins
ISU58_06905	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU58_06910	COG1823	symporter activity
ISU58_06915	COG1988	membrane-bound metal-dependent
ISU58_06920	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU58_06925	COG1653	transport
ISU58_06930	COG3842	ATPase activity
ISU58_06935	COG0395	ABC-type sugar transport system, permease component
ISU58_06940	COG1175	transmembrane transport
ISU58_06950	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_06960	COG1917	Cupin 2, conserved barrel domain protein
ISU58_06965	COG3328	transposase activity
ISU58_06970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU58_06980	COG3001	Fructosamine kinase
ISU58_06990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU58_06995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU58_07000	COG1121	(ABC) transporter
ISU58_07005	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISU58_07025	COG4249	Peptidase C14 caspase catalytic subunit p20
ISU58_07060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISU58_07060	COG0072	phenylalanine-tRNA ligase activity
ISU58_07065	COG0776	regulation of translation
ISU58_07080	COG0386	Belongs to the glutathione peroxidase family
ISU58_07130	COG0791	NLP P60 protein
ISU58_07155	COG0574	Belongs to the PEP-utilizing enzyme family
ISU58_07155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU58_07165	COG0628	permease
ISU58_07170	COG0277	FAD linked oxidase domain protein
ISU58_07170	COG0247	lactate metabolic process
ISU58_07175	COG2050	protein possibly involved in aromatic compounds catabolism
ISU58_07180	COG0316	Belongs to the HesB IscA family
ISU58_07185	COG0719	Fe-S assembly protein
ISU58_07190	COG0396	ATPase activity
ISU58_07195	COG0719	Fe-S assembly protein
ISU58_07210	COG1376	ErfK ybiS ycfS ynhG family protein
ISU58_07210	COG1388	LysM domain
ISU58_07265	COG0307	riboflavin synthase, alpha
ISU58_07270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISU58_07275	COG2814	Major facilitator Superfamily
ISU58_07280	COG0583	DNA-binding transcription factor activity
ISU58_07300	COG0791	NLP P60 protein
ISU58_07305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISU58_07315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISU58_07320	COG0346	lactoylglutathione lyase activity
ISU58_07330	COG1309	transcriptional regulator
ISU58_07335	COG2194	sulfuric ester hydrolase activity
ISU58_07345	COG3133	Outer membrane lipoprotein
ISU58_07355	COG3895	Periplasmic Protein
ISU58_07375	COG0625	glutathione transferase activity
ISU58_07390	COG3104	oligopeptide transport
ISU58_07395	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU58_07395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU58_07400	COG4172	Belongs to the ABC transporter superfamily
ISU58_07410	COG4171	peptide transport system, permease
ISU58_07415	COG4168	peptide transport system, permease
ISU58_07420	COG4166	transmembrane transport
ISU58_07430	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISU58_07435	COG1842	Phage shock protein A
ISU58_07445	COG1983	PspC domain protein
ISU58_07455	COG3106	COG3106 Predicted ATPase
ISU58_07465	COG5654	RES domain protein
ISU58_07470	COG5642	Protein of unknown function (DUF2384)
ISU58_07485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISU58_07490	COG4948	Mandelate Racemase Muconate Lactonizing
ISU58_07495	COG2866	Carboxypeptidase
ISU58_07500	COG4166	transmembrane transport
ISU58_07515	COG0657	acetylesterase activity
ISU58_07525	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISU58_07525	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISU58_07525	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISU58_07525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU58_07535	COG1285	pathogenesis
ISU58_07540	COG3042	response to heat
ISU58_07545	COG3187	Heat shock protein
ISU58_07550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU58_07555	COG2911	Protein conserved in bacteria
ISU58_07565	COG3784	Protein of unknown function (DUF1318)
ISU58_07570	COG0246	Mannitol dehydrogenase
ISU58_07575	COG2390	Transcriptional regulator
ISU58_07585	COG1643	Atp-dependent helicase
ISU58_07600	COG3591	Belongs to the peptidase S1B family
ISU58_07640	COG1454	alcohol dehydrogenase
ISU58_07640	COG1012	belongs to the aldehyde dehydrogenase family
ISU58_07645	COG2095	MarC family integral membrane protein
ISU58_07655	COG0601	transmembrane transport
ISU58_07660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU58_07665	COG0444	Belongs to the ABC transporter superfamily
ISU58_07670	COG4608	Belongs to the ABC transporter superfamily
ISU58_07715	COG2350	Protein conserved in bacteria
ISU58_07720	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ISU58_07725	COG3328	transposase activity
ISU58_07760	COG3047	cAMP biosynthetic process
ISU58_07780	COG0134	indole-3-glycerol-phosphate synthase activity
ISU58_07780	COG0135	phosphoribosylanthranilate isomerase activity
ISU58_07790	COG0512	Glutamine amidotransferase of anthranilate synthase
ISU58_07810	COG0009	L-threonylcarbamoyladenylate synthase
ISU58_07815	COG1187	pseudouridine synthase activity
ISU58_07825	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_07830	COG0616	signal peptide processing
ISU58_07850	COG0583	DNA-binding transcription factor activity
ISU58_07860	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISU58_07870	COG0671	phosphoesterase, PA-phosphatase related
ISU58_07875	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISU58_07880	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISU58_07895	COG0023	Translation Initiation Factor
ISU58_07915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISU58_07920	COG2879	small protein
ISU58_07925	COG1966	Carbon starvation protein
ISU58_07935	COG2271	Major facilitator Superfamily
ISU58_07940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU58_07945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISU58_07955	COG4659	FMN binding
ISU58_07960	COG4658	electron transport chain
ISU58_07965	COG2207	Transcriptional regulator
ISU58_07965	COG3708	Transcriptional regulator
ISU58_07995	COG1132	(ABC) transporter
ISU58_08005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU58_08010	COG2274	protein secretion by the type I secretion system
ISU58_08025	COG1879	ABC-type sugar transport system periplasmic component
ISU58_08030	COG1129	ABC transporter
ISU58_08035	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_08045	COG0673	inositol 2-dehydrogenase activity
ISU58_08050	COG0385	Bile acid
ISU58_08060	COG5339	Protein conserved in bacteria
ISU58_08070	COG0114	fumarate hydratase activity
ISU58_08080	COG2814	Major facilitator Superfamily
ISU58_08085	COG0583	DNA-binding transcription factor activity
ISU58_08090	COG1940	carbohydrate kinase activity
ISU58_08095	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISU58_08100	COG0038	chloride channel
ISU58_08105	COG1609	Transcriptional regulator
ISU58_08125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU58_08135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISU58_08165	COG0028	Belongs to the TPP enzyme family
ISU58_08170	COG0440	acetolactate synthase activity
ISU58_08175	COG1011	Hydrolase
ISU58_08190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU58_08195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISU58_08200	COG0589	response to stress
ISU58_08205	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISU58_08210	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISU58_08220	COG0531	amino acid
ISU58_08230	COG0745	RESPONSE REGULATOR receiver
ISU58_08235	COG2205	protein histidine kinase activity
ISU58_08240	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISU58_08275	COG0745	RESPONSE REGULATOR receiver
ISU58_08285	COG0788	formyltetrahydrofolate deformylase activity
ISU58_08290	COG3328	transposase activity
ISU58_08310	COG0583	DNA-binding transcription factor activity
ISU58_08315	COG0708	Exodeoxyribonuclease III
ISU58_08320	COG0494	nUDIX hydrolase
ISU58_08330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISU58_08335	COG0709	Synthesizes selenophosphate from selenide and ATP
ISU58_08340	COG0778	Nitroreductase
ISU58_08345	COG0616	signal peptide processing
ISU58_08350	COG0252	asparaginase activity
ISU58_08355	COG1335	isochorismatase
ISU58_08360	COG3139	Protein of unknown function (DUF1315)
ISU58_08380	COG3713	MltA-interacting MipA family protein
ISU58_08385	COG2766	serine protein kinase
ISU58_08400	COG0583	DNA-binding transcription factor activity
ISU58_08410	COG2814	Major facilitator Superfamily
ISU58_08420	COG2719	SpoVR family
ISU58_08450	COG1104	cysteine desulfurase activity
ISU58_08460	COG3328	transposase activity
ISU58_08620	COG3328	transposase activity
ISU58_08720	COG0582	viral genome integration into host DNA
ISU58_08730	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISU58_08735	COG2951	lytic endotransglycosylase activity
ISU58_08750	COG2894	cell division
ISU58_08755	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISU58_08765	COG0318	PFAM AMP-dependent synthetase and ligase
ISU58_08785	COG1199	ATP-dependent helicase activity
ISU58_08790	COG0251	oxidation-reduction process
ISU58_08805	COG0800	Aldolase
ISU58_08810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISU58_08815	COG1737	Transcriptional regulator
ISU58_08820	COG0469	pyruvate kinase activity
ISU58_08830	COG1560	Kdo2-lipid A biosynthetic process
ISU58_08835	COG0739	heme binding
ISU58_08840	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISU58_08850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU58_08875	COG0494	nUDIX hydrolase
ISU58_08885	COG1801	Protein of unknown function DUF72
ISU58_08890	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISU58_08910	COG3102	Protein conserved in bacteria
ISU58_08930	COG0728	peptidoglycan biosynthetic process
ISU58_08940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU58_08955	COG3381	protein complex oligomerization
ISU58_08970	COG1940	carbohydrate kinase activity
ISU58_08975	COG0584	glycerophosphoryl diester phosphodiesterase
ISU58_08995	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU58_09000	COG3833	ABC-type maltose transport systems, permease component
ISU58_09020	COG0659	secondary active sulfate transmembrane transporter activity
ISU58_09040	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU58_09065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISU58_09080	COG0012	GTP binding
ISU58_09130	COG5002	protein histidine kinase activity
ISU58_09175	COG0500	methyltransferase
ISU58_09195	COG3328	transposase activity
ISU58_09240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU58_09245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU58_09250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU58_09265	COG0402	S-adenosylhomocysteine deaminase activity
ISU58_09330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISU58_09340	COG3850	Histidine kinase
ISU58_09345	COG0387	Pfam Sodium calcium exchanger
ISU58_09365	COG3658	cytochrome
ISU58_09375	COG1649	PFAM Uncharacterised BCR, COG1649
ISU58_09375	COG0726	polysaccharide deacetylase
ISU58_09380	COG0457	Tetratricopeptide repeat
ISU58_09385	COG0006	proline dipeptidase activity
ISU58_09405	COG1136	(ABC) transporter
ISU58_09405	COG0577	efflux transmembrane transporter activity
ISU58_09430	COG0672	)-iron permease
ISU58_09445	COG2066	Belongs to the glutaminase family
ISU58_09455	COG1349	DNA-binding transcription factor activity
ISU58_09465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISU58_09470	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU58_09510	COG2030	dehydratase
ISU58_09545	COG3188	usher protein
ISU58_09555	COG3121	Chaperone
ISU58_09565	COG0582	viral genome integration into host DNA
ISU58_09570	COG1169	isochorismate synthase
ISU58_09575	COG2814	Major facilitator Superfamily
ISU58_09580	COG1132	(ABC) transporter
ISU58_09620	COG4771	TonB-dependent receptor
ISU58_09675	COG3842	ATPase activity
ISU58_09680	COG0395	ABC-type sugar transport system, permease component
ISU58_09685	COG1175	transmembrane transport
ISU58_09695	COG0673	inositol 2-dehydrogenase activity
ISU58_09700	COG2188	Transcriptional regulator
ISU58_09825	COG2197	response regulator
ISU58_09835	COG3136	membrane protein required for alginate biosynthesis
ISU58_09855	COG1113	amino acid transport
ISU58_09875	COG2822	iron ion transport
ISU58_09880	COG0672	)-iron permease
ISU58_09895	COG0506	proline dehydrogenase activity
ISU58_09895	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU58_09895	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU58_09910	COG1126	abc transporter atp-binding protein
ISU58_09915	COG0765	amino acid transport
ISU58_09920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_09935	COG1191	sigma factor activity
ISU58_09965	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ISU58_09970	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISU58_09975	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISU58_09995	COG1677	Flagellar hook-basal body complex protein FliE
ISU58_10015	COG1157	protein secretion by the type III secretion system
ISU58_10030	COG1580	Controls the rotational direction of flagella during chemotaxis
ISU58_10055	COG1987	bacterial-type flagellum assembly
ISU58_10075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU58_10080	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_10085	COG1129	ABC transporter
ISU58_10095	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_10100	COG3347	Dehydrogenase
ISU58_10100	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_10105	COG2390	Transcriptional regulator
ISU58_10115	COG1256	bacterial-type flagellum assembly
ISU58_10155	COG1558	bacterial-type flagellum-dependent cell motility
ISU58_10160	COG1815	bacterial-type flagellum-dependent cell motility
ISU58_10170	COG2747	anti-sigma28 factor FlgM
ISU58_10175	COG3418	PFAM FlgN family protein
ISU58_10200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU58_10205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU58_10230	COG2372	response to copper ion
ISU58_10235	COG1528	Iron-storage protein
ISU58_10250	COG1770	oligopeptidase
ISU58_10265	COG3141	response to X-ray
ISU58_10270	COG0513	Belongs to the DEAD box helicase family
ISU58_10295	COG1760	l-serine dehydratase
ISU58_10300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISU58_10305	COG2368	4-hydroxyphenylacetate
ISU58_10320	COG3971	2-oxopent-4-enoate hydratase activity
ISU58_10330	COG3384	dioxygenase
ISU58_10335	COG1012	belongs to the aldehyde dehydrogenase family
ISU58_10350	COG1846	Transcriptional regulator
ISU58_10355	COG1253	flavin adenine dinucleotide binding
ISU58_10360	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU58_10360	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU58_10365	COG3715	PTS system
ISU58_10370	COG3716	PTS system mannose fructose sorbose family IID component
ISU58_10400	COG2226	methyltransferase
ISU58_10405	COG1496	oxidoreductase activity
ISU58_10425	COG1113	amino acid transport
ISU58_10460	COG2207	Transcriptional regulator
ISU58_10470	COG1132	(ABC) transporter
ISU58_10515	COG3328	transposase activity
ISU58_10520	COG2223	nitrite transmembrane transporter activity
ISU58_10540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISU58_10565	COG3122	Protein conserved in bacteria
ISU58_10585	COG0534	Mate efflux family protein
ISU58_10600	COG4948	Mandelate Racemase Muconate Lactonizing
ISU58_10610	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_10615	COG3011	Protein conserved in bacteria
ISU58_10620	COG2271	Major facilitator Superfamily
ISU58_10625	COG1470	cell adhesion involved in biofilm formation
ISU58_10625	COG1388	LysM domain
ISU58_10630	COG3328	transposase activity
ISU58_10645	COG2925	Exonuclease
ISU58_10655	COG0531	amino acid
ISU58_10660	COG0371	Dehydrogenase
ISU58_10665	COG1129	ABC transporter
ISU58_10670	COG1129	ABC transporter
ISU58_10675	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_10690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU58_10705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISU58_10715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU58_10715	COG0131	Imidazoleglycerol-phosphate dehydratase
ISU58_10735	COG0140	phosphoribosyl-ATP diphosphatase activity
ISU58_10735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISU58_10745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU58_10750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU58_10765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU58_10770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_10775	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_10780	COG1120	ATPase activity
ISU58_10795	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ISU58_10800	COG0076	glutamate decarboxylase activity
ISU58_10805	COG4114	ferric iron reductase
ISU58_10810	COG1253	flavin adenine dinucleotide binding
ISU58_10815	COG2982	Protein involved in outer membrane biogenesis
ISU58_10830	COG0489	protein tyrosine kinase activity
ISU58_10860	COG2814	Major facilitator Superfamily
ISU58_10870	COG1346	cytolysis
ISU58_10885	COG2949	membrane
ISU58_10890	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISU58_10905	COG2311	Membrane
ISU58_10915	COG0477	Major facilitator Superfamily
ISU58_10920	COG0583	DNA-binding transcription factor activity
ISU58_10950	COG1136	(ABC) transporter
ISU58_10960	COG0303	'Molybdopterin
ISU58_10970	COG3328	transposase activity
ISU58_10980	COG0488	(ABC) transporter
ISU58_11110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISU58_11115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISU58_11125	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_11140	COG3425	synthase
ISU58_11145	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_11150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU58_11155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISU58_11165	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_11190	COG2920	part of a sulfur-relay system
ISU58_11210	COG1832	CoA-binding protein
ISU58_11225	COG0210	DNA helicase
ISU58_11230	COG3304	Inner membrane component domain
ISU58_11235	COG1289	transmembrane transporter activity
ISU58_11240	COG3070	regulator of competence-specific genes
ISU58_11265	COG1067	ATP-dependent peptidase activity
ISU58_11305	COG3130	regulation of translation
ISU58_11310	COG3009	Protein conserved in bacteria
ISU58_11315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU58_11315	COG3008	intermembrane lipid transfer
ISU58_11320	COG2995	paraquat-inducible protein a
ISU58_11325	COG0488	(ABC) transporter
ISU58_11335	COG0633	Ferredoxin
ISU58_11335	COG3217	Mosc domain protein beta barrel domain protein
ISU58_11350	COG0308	aminopeptidase N
ISU58_11370	COG1448	Aminotransferase
ISU58_11380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU58_11385	COG3108	Peptidase M15
ISU58_11390	COG2989	Protein conserved in bacteria
ISU58_11415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISU58_11420	COG3173	Aminoglycoside phosphotransferase
ISU58_11435	COG1278	Cold shock
ISU58_11440	COG5383	Protein conserved in bacteria
ISU58_11455	COG2333	competence protein COMEC
ISU58_11455	COG0658	competence protein
ISU58_11465	COG0539	negative regulation of cytoplasmic translation
ISU58_11490	COG5295	Hep Hag repeat protein
ISU58_11490	COG5295	Hep Hag repeat protein
ISU58_11495	COG0252	asparaginase activity
ISU58_11500	COG1944	ATP diphosphatase activity
ISU58_11505	COG2116	formate transmembrane transporter activity
ISU58_11510	COG1882	Formate acetyltransferase
ISU58_11520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISU58_11550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISU58_11560	COG3107	peptidoglycan biosynthetic process
ISU58_11560	COG1674	ftsk spoiiie
ISU58_11570	COG0492	ferredoxin-NADP+ reductase activity
ISU58_11580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISU58_11590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ISU58_11600	COG0542	response to heat
ISU58_11610	COG1278	Cold shock
ISU58_11620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU58_11625	COG2990	Protein conserved in bacteria
ISU58_11630	COG3593	DNA synthesis involved in DNA repair
ISU58_11635	COG2431	L-lysine efflux transmembrane transporter activity
ISU58_11645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU58_11650	COG0028	Belongs to the TPP enzyme family
ISU58_11660	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISU58_11665	COG0702	epimerase
ISU58_11670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU58_11680	COG1605	Chorismate mutase
ISU58_11685	COG1126	abc transporter atp-binding protein
ISU58_11690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_11695	COG4215	(ABC) transporter
ISU58_11700	COG4160	amino acid transport
ISU58_11725	COG1120	ATPase activity
ISU58_11730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_11735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_11760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_11775	COG1177	transmembrane transport
ISU58_11780	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU58_11785	COG3842	ATPase activity
ISU58_11790	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISU58_11820	COG0671	phosphoesterase, PA-phosphatase related
ISU58_11830	COG1349	DNA-binding transcription factor activity
ISU58_11835	COG0814	amino acid
ISU58_11840	COG1686	Belongs to the peptidase S11 family
ISU58_11845	COG2011	ABC-type metal ion transport system permease component
ISU58_11870	COG0625	glutathione transferase activity
ISU58_11875	COG4771	TonB-dependent receptor
ISU58_11885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_11900	COG0583	DNA-binding transcription factor activity
ISU58_11905	COG2855	membrane
ISU58_11915	COG3188	usher protein
ISU58_11920	COG3121	Chaperone
ISU58_11935	COG3710	Transcriptional regulator
ISU58_11940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU58_11940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU58_11940	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISU58_11945	COG1105	Belongs to the carbohydrate kinase PfkB family
ISU58_11955	COG0494	nUDIX hydrolase
ISU58_11965	COG1129	ABC transporter
ISU58_12000	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_12025	COG0246	Mannitol dehydrogenase
ISU58_12030	COG2186	Transcriptional regulator
ISU58_12040	COG0671	phosphoesterase, PA-phosphatase related
ISU58_12045	COG0791	NLP P60 protein
ISU58_12050	COG2200	EAL domain
ISU58_12055	COG4166	transmembrane transport
ISU58_12060	COG4174	ABC transporter (Permease)
ISU58_12065	COG4239	(ABC) transporter, permease
ISU58_12070	COG4172	Belongs to the ABC transporter superfamily
ISU58_12080	COG2814	Major facilitator Superfamily
ISU58_12085	COG1187	pseudouridine synthase activity
ISU58_12090	COG1061	Type III restriction enzyme res subunit
ISU58_12110	COG3082	Protein of unknown function (DUF1414)
ISU58_12115	COG3083	sulfuric ester hydrolase activity
ISU58_12130	COG3157	Type VI secretion system effector, Hcp
ISU58_12150	COG2723	6-phospho-beta-galactosidase activity
ISU58_12155	COG1737	Transcriptional regulator
ISU58_12175	COG3299	homolog of phage Mu protein gp47
ISU58_12215	COG4386	tail sheath protein
ISU58_12235	COG3622	Belongs to the hyi family
ISU58_12240	COG1349	DNA-binding transcription factor activity
ISU58_12290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISU58_12315	COG2223	nitrite transmembrane transporter activity
ISU58_12320	COG2198	Histidine kinase
ISU58_12320	COG0642	Histidine kinase
ISU58_12325	COG2198	Histidine kinase
ISU58_12325	COG0642	Histidine kinase
ISU58_12335	COG0784	Response regulator, receiver
ISU58_12335	COG2205	protein histidine kinase activity
ISU58_12360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU58_12375	COG0814	amino acid
ISU58_12410	COG0697	spore germination
ISU58_12420	COG1982	Orn Lys Arg decarboxylase major
ISU58_12425	COG0531	amino acid
ISU58_12430	COG1174	glycine betaine transport
ISU58_12435	COG1125	glycine betaine transport
ISU58_12440	COG1174	glycine betaine transport
ISU58_12450	COG2897	thiosulfate sulfurtransferase activity
ISU58_12470	COG1122	ATPase activity
ISU58_12490	COG4807	Protein conserved in bacteria
ISU58_12505	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISU58_12515	COG2261	transglycosylase associated protein
ISU58_12535	COG0277	FAD linked oxidase domain protein
ISU58_12540	COG1686	Belongs to the peptidase S11 family
ISU58_12550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU58_12565	COG0670	Belongs to the BI1 family
ISU58_12570	COG0314	molybdopterin synthase activity
ISU58_12575	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISU58_12585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISU58_12590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ISU58_12595	COG4628	conserved protein (DUF2132)
ISU58_12605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISU58_12615	COG2226	methyltransferase
ISU58_12640	COG0561	phosphatase activity
ISU58_12650	COG4149	molybdate abc transporter
ISU58_12655	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISU58_12665	COG3585	molybdate ion transport
ISU58_12665	COG2005	Transcriptional regulator
ISU58_12670	COG1119	ATPase activity
ISU58_12680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISU58_12685	COG1085	galactose-1-phosphate uridylyltransferase
ISU58_12700	COG2017	converts alpha-aldose to the beta-anomer
ISU58_12715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU58_12720	COG1230	cation diffusion facilitator family transporter
ISU58_12750	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISU58_12755	COG2885	chlorophyll binding
ISU58_12765	COG3064	Membrane
ISU58_12765	COG3064	Membrane
ISU58_12770	COG0848	biopolymer transport protein
ISU58_12775	COG0811	peptide transport
ISU58_12780	COG0824	Thioesterase
ISU58_12785	COG3790	cyd operon protein YbgE
ISU58_12790	COG4890	Cyd operon protein YbgT
ISU58_12795	COG1294	oxidase, subunit
ISU58_12800	COG1271	oxidase subunit
ISU58_12805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISU58_12815	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU58_12820	COG0567	Dehydrogenase, E1 component
ISU58_12830	COG1053	succinate dehydrogenase
ISU58_12835	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISU58_12840	COG2009	succinate dehydrogenase
ISU58_12855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISU58_12860	COG0497	DNA recombination
ISU58_12865	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU58_12875	COG2867	negative regulation of translational initiation
ISU58_12895	COG0582	viral genome integration into host DNA
ISU58_12945	COG3657	addiction module killer protein
ISU58_12970	COG1953	Uracil, thiamine, allantoin
ISU58_12990	COG2226	methyltransferase
ISU58_13000	COG0741	lytic transglycosylase activity
ISU58_13000	COG1388	LysM domain
ISU58_13015	COG0656	L-ascorbic acid biosynthetic process
ISU58_13045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU58_13055	COG2011	ABC-type metal ion transport system permease component
ISU58_13060	COG1464	Belongs to the NlpA lipoprotein family
ISU58_13070	COG1720	tRNA m6t6A37 methyltransferase activity
ISU58_13080	COG3015	lipoprotein NlpE involved in copper resistance
ISU58_13090	COG4681	YaeQ
ISU58_13100	COG4568	rho-dependent transcription termination
ISU58_13110	COG0037	tRNA processing
ISU58_13115	COG0346	lactoylglutathione lyase activity
ISU58_13125	COG0587	DNA-directed DNA polymerase activity
ISU58_13150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU58_13165	COG0750	zinc metalloprotease
ISU58_13170	COG0575	Belongs to the CDS family
ISU58_13230	COG0564	pseudouridine synthase activity
ISU58_13235	COG3098	single-species biofilm formation
ISU58_13255	COG1611	Belongs to the LOG family
ISU58_13280	COG2363	Small membrane protein
ISU58_13285	COG0583	DNA-binding transcription factor activity
ISU58_13295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISU58_13300	COG2166	iron-sulfur cluster assembly
ISU58_13305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISU58_13310	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISU58_13325	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU58_13335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISU58_13340	COG1074	ATP-dependent DNA helicase activity
ISU58_13350	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISU58_13400	COG0667	Aldo Keto reductase
ISU58_13430	COG1609	Transcriptional regulator
ISU58_13440	COG0583	DNA-binding transcription factor activity
ISU58_13445	COG2814	Major facilitator Superfamily
ISU58_13450	COG0583	DNA-binding transcription factor activity
ISU58_13465	COG0840	transmembrane signaling receptor activity
ISU58_13510	COG2165	general secretion pathway protein
ISU58_13530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU58_13550	COG0288	reversible hydration of carbon dioxide
ISU58_13590	COG3119	arylsulfatase activity
ISU58_13595	COG1349	DNA-binding transcription factor activity
ISU58_13605	COG2222	sugar isomerase
ISU58_13610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU58_13615	COG3715	PTS system
ISU58_13620	COG3716	PTS system mannose fructose sorbose family IID component
ISU58_13625	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU58_13635	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_13645	COG0641	radical SAM
ISU58_13650	COG3119	arylsulfatase activity
ISU58_13675	COG2271	Major facilitator Superfamily
ISU58_13695	COG1263	PTS System
ISU58_13695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU58_13700	COG1874	Beta-galactosidase
ISU58_13705	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISU58_13710	COG3833	ABC-type maltose transport systems, permease component
ISU58_13715	COG1175	transmembrane transport
ISU58_13720	COG2182	Extracellular solute-binding protein
ISU58_13730	COG1129	ABC transporter
ISU58_13735	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_13740	COG1879	ABC-type sugar transport system periplasmic component
ISU58_13750	COG0791	NLP P60 protein
ISU58_13755	COG1695	Transcriptional regulator
ISU58_13845	COG2944	sequence-specific DNA binding
ISU58_13870	COG0582	viral genome integration into host DNA
ISU58_13890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISU58_13895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU58_13900	COG4974	Belongs to the 'phage' integrase family
ISU58_13905	COG0716	FMN binding
ISU58_13910	COG4452	Inner membrane protein CreD
ISU58_13915	COG2205	protein histidine kinase activity
ISU58_13920	COG0745	RESPONSE REGULATOR receiver
ISU58_13945	COG1272	protein, Hemolysin III
ISU58_13990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU58_13995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU58_14000	COG0006	proline dipeptidase activity
ISU58_14020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISU58_14030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISU58_14065	COG0191	fructose-bisphosphate aldolase activity
ISU58_14085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISU58_14090	COG0501	Belongs to the peptidase M48B family
ISU58_14105	COG1166	arginine decarboxylase activity
ISU58_14120	COG2356	endonuclease I
ISU58_14125	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISU58_14130	COG0189	ligase activity
ISU58_14145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU58_14155	COG2805	Type II/IV secretion system protein
ISU58_14160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISU58_14165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISU58_14170	COG0762	integral membrane protein
ISU58_14180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISU58_14185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU58_14190	COG1073	alpha beta
ISU58_14190	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ISU58_14190	COG3064	Membrane
ISU58_14210	COG3171	Protein conserved in bacteria
ISU58_14220	COG1194	a g-specific adenine glycosylase
ISU58_14240	COG4774	siderophore transport
ISU58_14245	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_14250	COG1129	ABC transporter
ISU58_14255	COG1879	ABC-type sugar transport system periplasmic component
ISU58_14260	COG1982	Orn Lys Arg decarboxylase major
ISU58_14380	COG3916	Acyl-homoserine-lactone synthase
ISU58_14385	COG2771	luxR family
ISU58_14435	COG2211	Major facilitator Superfamily
ISU58_14445	COG5001	Diguanylate cyclase
ISU58_14455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU58_14500	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISU58_14505	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU58_14510	COG4771	TonB-dependent receptor
ISU58_14535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU58_14535	COG2226	methyltransferase
ISU58_14535	COG3433	isochorismatase activity
ISU58_14540	COG3433	isochorismatase activity
ISU58_14540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU58_14540	COG2226	methyltransferase
ISU58_14565	COG2375	cellular response to nickel ion
ISU58_14565	COG1132	(ABC) transporter
ISU58_14570	COG1132	(ABC) transporter
ISU58_14585	COG2610	gluconate transmembrane transporter activity
ISU58_14600	COG3501	Rhs element vgr protein
ISU58_14625	COG0471	metal ion transport
ISU58_14650	COG3710	Transcriptional regulator
ISU58_14670	COG1256	bacterial-type flagellum assembly
ISU58_14680	COG1706	bacterial-type flagellum-dependent cell motility
ISU58_14690	COG4786	Flagellar basal body rod
ISU58_14695	COG4787	bacterial-type flagellum-dependent cell motility
ISU58_14700	COG1749	Flagellar hook protein flgE
ISU58_14705	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ISU58_14710	COG1558	bacterial-type flagellum-dependent cell motility
ISU58_14715	COG1815	bacterial-type flagellum-dependent cell motility
ISU58_14720	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ISU58_14760	COG1677	Flagellar hook-basal body complex protein FliE
ISU58_14785	COG1987	bacterial-type flagellum assembly
ISU58_14790	COG1684	flagellar biosynthetic protein fliR
ISU58_14795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU58_14815	COG4592	Periplasmic binding protein
ISU58_14850	COG4964	Belongs to the GSP D family
ISU58_14855	COG4964	Belongs to the GSP D family
ISU58_14905	COG0848	biopolymer transport protein
ISU58_14910	COG0811	peptide transport
ISU58_14915	COG0626	cystathionine gamma-synthase activity
ISU58_14920	COG0586	Pfam SNARE associated Golgi protein
ISU58_14925	COG2207	Transcriptional regulator
ISU58_14930	COG1979	alcohol dehydrogenase
ISU58_14940	COG0656	L-ascorbic acid biosynthetic process
ISU58_14950	COG2132	Multicopper oxidase
ISU58_14960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISU58_14970	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISU58_14975	COG0583	DNA-binding transcription factor activity
ISU58_14985	COG3150	esterase
ISU58_14990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISU58_14995	COG3151	Protein conserved in bacteria
ISU58_15000	COG0494	nUDIX hydrolase
ISU58_15005	COG1538	Outer membrane efflux protein
ISU58_15015	COG0754	glutathionylspermidine amidase activity
ISU58_15020	COG3384	dioxygenase
ISU58_15040	COG0531	amino acid
ISU58_15055	COG3025	triphosphatase activity
ISU58_15060	COG4991	sh3 domain protein
ISU58_15075	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISU58_15090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISU58_15095	COG0358	DNA primase activity
ISU58_15165	COG0251	oxidation-reduction process
ISU58_15205	COG1289	transmembrane transporter activity
ISU58_15225	COG0395	ABC-type sugar transport system, permease component
ISU58_15235	COG2182	Extracellular solute-binding protein
ISU58_15240	COG1609	Transcriptional regulator
ISU58_15245	COG3459	Glycosyltransferase 36 associated
ISU58_15250	COG3842	ATPase activity
ISU58_15270	COG3210	domain, Protein
ISU58_15275	COG3210	domain, Protein
ISU58_15305	COG3210	domain, Protein
ISU58_15310	COG2831	hemolysin activation secretion protein
ISU58_15315	COG4245	von Willebrand factor, type A
ISU58_15330	COG4245	von Willebrand factor, type A
ISU58_15345	COG3247	response to pH
ISU58_15350	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISU58_15350	COG1902	pentaerythritol trinitrate reductase activity
ISU58_15365	COG1451	nucleotide metabolic process
ISU58_15370	COG0673	inositol 2-dehydrogenase activity
ISU58_15390	COG2721	sulfolactate sulfo-lyase activity
ISU58_15405	COG2271	Major facilitator Superfamily
ISU58_15420	COG0586	Pfam SNARE associated Golgi protein
ISU58_15435	COG4575	ribosome binding
ISU58_15440	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISU58_15450	COG2259	Doxx family
ISU58_15470	COG0494	nUDIX hydrolase
ISU58_15500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISU58_15505	COG0849	cell division
ISU58_15510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISU58_15530	COG0772	Belongs to the SEDS family
ISU58_15545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISU58_15550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISU58_15555	COG0768	penicillin binding
ISU58_15560	COG3116	cell division
ISU58_15585	COG1609	Transcriptional regulator
ISU58_15600	COG0028	Belongs to the TPP enzyme family
ISU58_15605	COG1022	Amp-dependent synthetase and ligase
ISU58_15630	COG0473	3-isopropylmalate dehydrogenase activity
ISU58_15645	COG2814	Major facilitator Superfamily
ISU58_15655	COG4143	(ABC) transporter
ISU58_15660	COG1178	ABC-type Fe3 transport system permease component
ISU58_15665	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ISU58_15670	COG0586	Pfam SNARE associated Golgi protein
ISU58_15675	COG0417	DNA replication proofreading
ISU58_15695	COG3047	cAMP biosynthetic process
ISU58_15695	COG2885	chlorophyll binding
ISU58_15780	COG0564	pseudouridine synthase activity
ISU58_15785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISU58_15835	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISU58_15845	COG2966	Psort location CytoplasmicMembrane, score
ISU58_15850	COG1280	lysine exporter protein (LysE YggA)
ISU58_15855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISU58_15880	COG1047	Peptidyl-prolyl cis-trans
ISU58_15895	COG0196	riboflavin kinase activity
ISU58_15905	COG0583	DNA-binding transcription factor activity
ISU58_15925	COG1584	GPR1 FUN34 yaaH family protein
ISU58_15940	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISU58_15980	COG0745	RESPONSE REGULATOR receiver
ISU58_15985	COG3045	CreA protein
ISU58_15990	COG2207	Transcriptional regulator
ISU58_15990	COG3708	Transcriptional regulator
ISU58_16005	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ISU58_16010	COG0741	lytic transglycosylase activity
ISU58_16025	COG2199	diguanylate cyclase activity
ISU58_16030	COG2885	chlorophyll binding
ISU58_16055	COG0560	Phosphoserine phosphatase
ISU58_16060	COG3726	membrane protein affecting hemolysin expression
ISU58_16085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU58_16090	COG0084	hydrolase, TatD family'
ISU58_16095	COG4667	esterase of the alpha-beta hydrolase superfamily
ISU58_16105	COG2823	Periplasmic or secreted lipoprotein
ISU58_16115	COG0456	acetyltransferase
ISU58_16120	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISU58_16160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU58_16165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU58_16180	COG0859	PFAM glycosyl transferase family 9
ISU58_16185	COG1070	Carbohydrate kinase
ISU58_16250	COG1401	restriction endodeoxyribonuclease activity
ISU58_16305	COG4269	membrane
ISU58_16315	COG2207	Transcriptional regulator
ISU58_16320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU58_16325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU58_16330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU58_16360	COG1011	Hydrolase
ISU58_16370	COG0174	glutamine synthetase
ISU58_16375	COG3852	Histidine kinase
ISU58_16385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU58_16410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU58_16410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU58_16415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU58_16420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISU58_16425	COG3084	Protein conserved in bacteria
ISU58_16435	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISU58_16440	COG3328	transposase activity
ISU58_16480	COG2271	Major facilitator Superfamily
ISU58_16495	COG2831	hemolysin activation secretion protein
ISU58_16500	COG0747	negative chemotaxis
ISU58_16505	COG0601	transmembrane transport
ISU58_16510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU58_16515	COG0444	Belongs to the ABC transporter superfamily
ISU58_16520	COG4608	Belongs to the ABC transporter superfamily
ISU58_16525	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISU58_16530	COG2199	diguanylate cyclase activity
ISU58_16530	COG2200	EAL domain
ISU58_16535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU58_16555	COG0612	Peptidase, M16
ISU58_16560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU58_16565	COG1942	4-Oxalocrotonate Tautomerase
ISU58_16570	COG2200	EAL domain
ISU58_16575	COG2982	Protein involved in outer membrane biogenesis
ISU58_16580	COG2134	cdp-diacylglycerol pyrophosphatase
ISU58_16585	COG1295	ribonuclease BN
ISU58_16610	COG1929	Belongs to the glycerate kinase type-1 family
ISU58_16625	COG3835	regulator
ISU58_16630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU58_16635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISU58_16640	COG0339	signal peptide processing
ISU58_16660	COG0589	response to stress
ISU58_16675	COG0306	phosphate transporter
ISU58_16680	COG2081	HI0933 family
ISU58_16695	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_16710	COG0191	fructose-bisphosphate aldolase activity
ISU58_16730	COG1741	Belongs to the pirin family
ISU58_16735	COG1609	Transcriptional regulator
ISU58_16740	COG2610	gluconate transmembrane transporter activity
ISU58_16745	COG3265	gluconokinase activity
ISU58_16760	COG2095	MarC family integral membrane protein
ISU58_16765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU58_16800	COG3275	phosphorelay sensor kinase activity
ISU58_16825	COG0058	SHG alpha-glucan phosphorylase activity
ISU58_16830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU58_16875	COG0195	Participates in both transcription termination and antitermination
ISU58_16895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISU58_16905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISU58_16920	COG1534	Rna-binding protein
ISU58_16930	COG2027	D-alanyl-D-alanine carboxypeptidase
ISU58_16935	COG0745	RESPONSE REGULATOR receiver
ISU58_16940	COG0642	Histidine kinase
ISU58_16950	COG0697	spore germination
ISU58_16965	COG0142	geranyltranstransferase activity
ISU58_16975	COG3423	Transcriptional regulator
ISU58_16995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISU58_17000	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ISU58_17005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISU58_17010	COG2105	PFAM AIG2 family protein
ISU58_17015	COG2911	Protein conserved in bacteria
ISU58_17020	COG0729	surface antigen
ISU58_17030	COG1253	flavin adenine dinucleotide binding
ISU58_17040	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISU58_17050	COG0737	Belongs to the 5'-nucleotidase family
ISU58_17060	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU58_17065	COG3061	Opacity-associated protein A
ISU58_17085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISU58_17095	COG0360	Binds together with S18 to 16S ribosomal RNA
ISU58_17100	COG1073	alpha beta
ISU58_17120	COG3650	response to hydrogen peroxide
ISU58_17125	COG1960	acyl-CoA dehydrogenase activity
ISU58_17130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU58_17135	COG0557	exoribonuclease II activity
ISU58_17150	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISU58_17155	COG0330	HflC and HflK could
ISU58_17160	COG0330	HflC and HflK could
ISU58_17165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISU58_17185	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU58_17190	COG0802	atpase or kinase
ISU58_17195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISU58_17195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISU58_17200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISU58_17215	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISU58_17230	COG3264	Mechanosensitive ion channel
ISU58_17230	COG1511	domain protein
ISU58_17245	COG1053	succinate dehydrogenase
ISU58_17250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISU58_17260	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ISU58_17320	COG3383	formate dehydrogenase (NAD+) activity
ISU58_17325	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU58_17330	COG0493	'glutamate synthase
ISU58_17330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU58_17335	COG1309	transcriptional regulator
ISU58_17395	COG1454	alcohol dehydrogenase
ISU58_17405	COG0629	single-stranded DNA binding
ISU58_17410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISU58_17415	COG2315	Protein conserved in bacteria
ISU58_17420	COG1448	Aminotransferase
ISU58_17445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU58_17450	COG0735	belongs to the Fur family
ISU58_17460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISU58_17500	COG3121	Chaperone
ISU58_17560	COG1358	cellular component organization or biogenesis
ISU58_17585	COG3721	Heme iron utilization protein
ISU58_17590	COG0702	epimerase
ISU58_17600	COG4771	TonB-dependent receptor
ISU58_17605	COG3720	iron ion transport
ISU58_17610	COG4558	Periplasmic binding protein
ISU58_17615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_17625	COG0626	cystathionine gamma-synthase activity
ISU58_17630	COG0814	amino acid
ISU58_17635	COG0583	DNA-binding transcription factor activity
ISU58_17640	COG0425	Belongs to the sulfur carrier protein TusA family
ISU58_17645	COG2391	methyltransferase activity
ISU58_17755	COG1301	dicarboxylic acid transport
ISU58_17765	COG3162	membrane
ISU58_17825	COG0151	Belongs to the GarS family
ISU58_17845	COG1515	deoxyribonuclease V activity
ISU58_17880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISU58_17935	COG0250	Participates in transcription elongation, termination and antitermination
ISU58_17995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISU58_18025	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISU58_18030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISU58_18045	COG1739	Uncharacterized protein family UPF0029
ISU58_18070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISU58_18105	COG0805	protein transport
ISU58_18115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU58_18135	COG1322	Protein conserved in bacteria
ISU58_18140	COG0586	Pfam SNARE associated Golgi protein
ISU58_18145	COG1966	Carbon starvation protein
ISU58_18160	COG0412	Dienelactone hydrolase
ISU58_18170	COG0583	DNA-binding transcription factor activity
ISU58_18175	COG0697	spore germination
ISU58_18180	COG0679	Auxin Efflux Carrier
ISU58_18185	COG0584	glycerophosphoryl diester phosphodiesterase
ISU58_18245	COG0410	ABC transporter
ISU58_18255	COG4177	L-phenylalanine transmembrane transporter activity
ISU58_18265	COG0683	leucine binding
ISU58_18285	COG2177	Part of the ABC transporter FtsEX involved in
ISU58_18290	COG2884	Cell division ATP-binding protein ftsE
ISU58_18295	COG0552	protein localization to endoplasmic reticulum
ISU58_18295	COG0552	protein localization to endoplasmic reticulum
ISU58_18300	COG0742	ribosomal rna small subunit methyltransferase
ISU58_18305	COG3776	membrane
ISU58_18320	COG3714	YhhN family
ISU58_18335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISU58_18345	COG0247	lactate metabolic process
ISU58_18355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU58_18360	COG0584	glycerophosphoryl diester phosphodiesterase
ISU58_18370	COG0561	phosphatase activity
ISU58_18375	COG2267	carboxylic ester hydrolase activity
ISU58_18380	COG1280	lysine exporter protein (LysE YggA)
ISU58_18385	COG1280	lysine exporter protein (LysE YggA)
ISU58_18390	COG0514	ATP-dependent DNA helicase (RecQ)
ISU58_18395	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ISU58_18400	COG2050	protein possibly involved in aromatic compounds catabolism
ISU58_18415	COG5564	TIM-barrel signal transduction protein
ISU58_18420	COG5441	Belongs to the UPF0261 family
ISU58_18430	COG0210	DNA helicase
ISU58_18435	COG1011	Hydrolase
ISU58_18440	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ISU58_18445	COG3159	Protein conserved in bacteria
ISU58_18465	COG3072	Adenylate cyclase
ISU58_18480	COG1587	Uroporphyrinogen-III synthase
ISU58_18485	COG2959	enzyme of heme biosynthesis
ISU58_18490	COG3071	HemY protein
ISU58_18520	COG1113	amino acid transport
ISU58_18540	COG2244	polysaccharide biosynthetic process
ISU58_18545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISU58_18550	COG0456	acetyltransferase
ISU58_18555	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISU58_18560	COG1088	dTDP-glucose 4,6-dehydratase activity
ISU58_18565	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISU58_18570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISU58_18575	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU58_18580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISU58_18585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISU58_18590	COG3118	belongs to the thioredoxin family
ISU58_18615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU58_18625	COG3328	transposase activity
ISU58_18635	COG3121	Chaperone
ISU58_18650	COG3121	Chaperone
ISU58_18685	COG0583	DNA-binding transcription factor activity
ISU58_18730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU58_18735	COG3978	acetolactate synthase activity
ISU58_18755	COG3085	chromosome segregation
ISU58_18765	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_18770	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_18775	COG1129	ABC transporter
ISU58_18780	COG1879	ABC-type sugar transport system periplasmic component
ISU58_18850	COG0678	peroxiredoxin activity
ISU58_18850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU58_18855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU58_18880	COG1629	transport
ISU58_18895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISU58_18920	COG0527	aspartate kinase activity
ISU58_18920	COG0460	homoserine dehydrogenase
ISU58_18935	COG4682	membrane
ISU58_18945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISU58_18950	COG1609	Transcriptional regulator
ISU58_18955	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU58_18970	COG1575	Belongs to the MenA family. Type 1 subfamily
ISU58_19020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISU58_19025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU58_19030	COG1494	fructose-1,6-bisphosphatase
ISU58_19040	COG3152	Membrane
ISU58_19055	COG0583	DNA-binding transcription factor activity
ISU58_19060	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISU58_19065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISU58_19070	COG0471	metal ion transport
ISU58_19080	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISU58_19105	COG3678	ATP-independent chaperone mediated protein folding
ISU58_19110	COG0745	RESPONSE REGULATOR receiver
ISU58_19115	COG2205	protein histidine kinase activity
ISU58_19120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU58_19120	COG2169	Transcriptional regulator
ISU58_19125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISU58_19130	COG1045	serine acetyltransferase
ISU58_19145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU58_19150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU58_19160	COG4942	peptidase
ISU58_19175	COG0156	8-amino-7-oxononanoate synthase activity
ISU58_19185	COG0859	PFAM glycosyl transferase family 9
ISU58_19190	COG0859	PFAM glycosyl transferase family 9
ISU58_19195	COG1519	Transferase
ISU58_19230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISU58_19255	COG1561	YicC-like family, N-terminal region
ISU58_19260	COG2860	membrane
ISU58_19280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU58_19285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU58_19290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISU58_19300	COG0786	glutamate:sodium symporter activity
ISU58_19305	COG2233	PERMEase
ISU58_19310	COG2982	Protein involved in outer membrane biogenesis
ISU58_19315	COG0456	acetyltransferase
ISU58_19335	COG0583	DNA-binding transcription factor activity
ISU58_19340	COG1741	Belongs to the pirin family
ISU58_19350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISU58_19370	COG2823	Periplasmic or secreted lipoprotein
ISU58_19380	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISU58_19385	COG0784	Response regulator, receiver
ISU58_19385	COG2198	Histidine kinase
ISU58_19385	COG5002	protein histidine kinase activity
ISU58_19390	COG1242	4 iron, 4 sulfur cluster binding
ISU58_19395	COG0070	glutamate synthase
ISU58_19395	COG0069	glutamate synthase activity
ISU58_19395	COG0067	glutamate synthase
ISU58_19400	COG0493	'glutamate synthase
ISU58_19410	COG2969	positive regulation of protein catabolic process
ISU58_19415	COG0625	glutathione transferase activity
ISU58_19435	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISU58_19440	COG3105	Protein conserved in bacteria
ISU58_19445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU58_19455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU58_19465	COG5007	Belongs to the BolA IbaG family
ISU58_19470	COG3113	response to antibiotic
ISU58_19475	COG2854	intermembrane phospholipid transfer
ISU58_19480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU58_19485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISU58_19490	COG1127	ABC transporter
ISU58_19495	COG0530	calcium, potassium:sodium antiporter activity
ISU58_19500	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISU58_19500	COG0517	IMP dehydrogenase activity
ISU58_19505	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISU58_19510	COG3117	lipopolysaccharide transmembrane transporter activity
ISU58_19515	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISU58_19520	COG1137	ATPase activity
ISU58_19525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISU58_19545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU58_19570	COG1609	Transcriptional regulator
ISU58_19575	COG1263	PTS System
ISU58_19575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU58_19580	COG0366	Alpha amylase catalytic
ISU58_19585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU58_19590	COG3783	Cytochrome b(562)
ISU58_19600	COG0312	modulator of DNA gyrase
ISU58_19610	COG2732	(Barnase) inhibitor
ISU58_19640	COG0583	DNA-binding transcription factor activity
ISU58_19690	COG0312	modulator of DNA gyrase
ISU58_19695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU58_19700	COG3164	Protein of unknown function
ISU58_19705	COG1530	ribonuclease E activity
ISU58_19710	COG0424	maF-like protein
ISU58_19715	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISU58_19720	COG1792	Involved in formation and maintenance of cell shape
ISU58_19725	COG1077	Cell shape determining protein MreB Mrl
ISU58_19730	COG2199	diguanylate cyclase activity
ISU58_19730	COG2200	EAL domain
ISU58_19735	COG0604	alcohol dehydrogenase
ISU58_19740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISU58_19755	COG0511	ligase activity, forming carbon-carbon bonds
ISU58_19760	COG0439	Biotin carboxylase
ISU58_19770	COG3924	membrane
ISU58_19775	COG4145	pantothenate transmembrane transporter activity
ISU58_19785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU58_19790	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISU58_19820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU58_19830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU58_19835	COG3133	Outer membrane lipoprotein
ISU58_19840	COG1278	Cold shock
ISU58_19845	COG1278	Cold shock
ISU58_19865	COG0625	glutathione transferase activity
ISU58_19875	COG1069	ribulokinase activity
ISU58_19885	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_19890	COG1129	ABC transporter
ISU58_19900	COG1560	Kdo2-lipid A biosynthetic process
ISU58_19910	COG0025	NhaP-type Na H and K H
ISU58_19915	COG2252	PERMEase
ISU58_19920	COG3077	Addiction module antitoxin, RelB DinJ family
ISU58_19935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU58_19945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISU58_19950	COG0431	NADPH-dependent FMN reductase
ISU58_19955	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISU58_19960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU58_19965	COG1869	D-ribose catabolic process
ISU58_19970	COG2207	Transcriptional regulator
ISU58_19970	COG1917	Cupin 2, conserved barrel domain protein
ISU58_19975	COG0673	inositol 2-dehydrogenase activity
ISU58_19995	COG3209	COG3209 Rhs family protein
ISU58_20005	COG3501	Rhs element vgr protein
ISU58_20050	COG3501	Rhs element vgr protein
ISU58_20195	COG1175	transmembrane transport
ISU58_20200	COG3833	ABC-type maltose transport systems, permease component
ISU58_20215	COG0527	aspartate kinase activity
ISU58_20245	COG2224	Isocitrate lyase
ISU58_20250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISU58_20290	COG2186	Transcriptional regulator
ISU58_20295	COG0477	Major facilitator Superfamily
ISU58_20310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU58_20340	COG1522	sequence-specific DNA binding
ISU58_20345	COG0716	FMN binding
ISU58_20360	COG3312	ion transport
ISU58_20415	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISU58_20420	COG0573	inorganic phosphate transmembrane transporter activity
ISU58_20425	COG0581	inorganic phosphate transmembrane transporter activity
ISU58_20435	COG0704	Plays a role in the regulation of phosphate uptake
ISU58_20445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_20450	COG0765	amino acid transport
ISU58_20455	COG0765	amino acid transport
ISU58_20460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU58_20470	COG2252	PERMEase
ISU58_20500	COG0706	membrane insertase activity
ISU58_20515	COG0230	Belongs to the bacterial ribosomal protein bL34 family