locus-tag	class	description
ISU65_00010	COG0592	DNA-directed DNA polymerase activity
ISU65_00025	COG0187	DNA topoisomerase II activity
ISU65_00030	COG0561	phosphatase activity
ISU65_00040	COG2423	ornithine cyclodeaminase activity
ISU65_00045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISU65_00055	COG5645	(Lipo)protein
ISU65_00075	COG3977	Valine--pyruvate aminotransferase
ISU65_00085	COG0366	Alpha amylase catalytic
ISU65_00100	COG2885	chlorophyll binding
ISU65_00110	COG2818	Glycosylase
ISU65_00135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_00135	COG2213	PTS system mannitol-specific
ISU65_00145	COG3722	fumarate hydratase activity
ISU65_00170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISU65_00185	COG0437	4 iron, 4 sulfur cluster binding
ISU65_00190	COG2864	formate dehydrogenase
ISU65_00205	COG3276	selenocysteine insertion sequence binding
ISU65_00250	COG3274	enterobacterial common antigen metabolic process
ISU65_00265	COG3121	Chaperone
ISU65_00275	COG1070	Carbohydrate kinase
ISU65_00285	COG4213	ABC transporter substrate-binding protein
ISU65_00295	COG4214	carbohydrate transport
ISU65_00300	COG1609	Transcriptional regulator
ISU65_00300	COG2207	Transcriptional regulator
ISU65_00310	COG0582	viral genome integration into host DNA
ISU65_00355	COG4604	ABC transporter, ATP-binding protein
ISU65_00360	COG4605	iron ion homeostasis
ISU65_00370	COG4607	ABC-type enterochelin transport system periplasmic component
ISU65_00400	COG2986	histidine ammonia-lyase
ISU65_00415	COG2194	sulfuric ester hydrolase activity
ISU65_00420	COG2197	response regulator
ISU65_00440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISU65_00455	COG0551	DNA topoisomerase type I activity
ISU65_00465	COG0758	DNA mediated transformation
ISU65_00495	COG3036	rescue of stalled ribosome
ISU65_00500	COG0789	Transcriptional regulator
ISU65_00515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISU65_00530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU65_00535	COG0201	protein transport
ISU65_00545	COG1841	ribosomal large subunit assembly
ISU65_00585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ISU65_00590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISU65_00600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISU65_00605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISU65_00615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISU65_00625	COG0089	rRNA binding
ISU65_00640	COG0051	transcription antitermination factor activity, RNA binding
ISU65_00670	COG0049	tRNA binding
ISU65_00675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ISU65_00695	COG2964	Protein conserved in bacteria
ISU65_00700	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU65_00710	COG1047	Peptidyl-prolyl cis-trans
ISU65_00715	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISU65_00735	COG1216	Glycosyl transferase, family 2
ISU65_00745	COG2175	clavaminate synthase activity
ISU65_00750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU65_00760	COG4521	taurine ABC transporter
ISU65_00770	COG0429	hydrolase of the alpha beta-hydrolase fold
ISU65_00780	COG3954	Phosphoribulokinase
ISU65_00790	COG1765	OsmC-like protein
ISU65_00800	COG1289	transmembrane transporter activity
ISU65_00815	COG0433	COG0433 Predicted ATPase
ISU65_00820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU65_00825	COG1486	melibiose metabolic process
ISU65_00845	COG0402	S-adenosylhomocysteine deaminase activity
ISU65_00850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISU65_00885	COG0180	Tryptophanyl-tRNA synthetase
ISU65_00890	COG0546	phosphoglycolate phosphatase activity
ISU65_00895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISU65_00920	COG4796	Type ii and iii secretion system protein
ISU65_00945	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISU65_00950	COG0494	nUDIX hydrolase
ISU65_00960	COG1011	Hydrolase
ISU65_00965	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISU65_00990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU65_00995	COG2183	response to ionizing radiation
ISU65_01000	COG1918	ferrous iron import across plasma membrane
ISU65_01035	COG1640	4-alpha-glucanotransferase
ISU65_01040	COG0058	SHG alpha-glucan phosphorylase activity
ISU65_01045	COG0058	SHG alpha-glucan phosphorylase activity
ISU65_01065	COG1349	DNA-binding transcription factor activity
ISU65_01090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU65_01095	COG0058	SHG alpha-glucan phosphorylase activity
ISU65_01120	COG3275	phosphorelay sensor kinase activity
ISU65_01155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU65_01160	COG2095	MarC family integral membrane protein
ISU65_01175	COG3265	gluconokinase activity
ISU65_01180	COG2610	gluconate transmembrane transporter activity
ISU65_01185	COG1609	Transcriptional regulator
ISU65_01190	COG1741	Belongs to the pirin family
ISU65_01210	COG0191	fructose-bisphosphate aldolase activity
ISU65_01225	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_01240	COG2081	HI0933 family
ISU65_01245	COG0306	phosphate transporter
ISU65_01260	COG0589	response to stress
ISU65_01280	COG0339	signal peptide processing
ISU65_01285	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISU65_01290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU65_01295	COG3835	regulator
ISU65_01305	COG2610	gluconate transmembrane transporter activity
ISU65_01310	COG1929	Belongs to the glycerate kinase type-1 family
ISU65_01335	COG1295	ribonuclease BN
ISU65_01340	COG2134	cdp-diacylglycerol pyrophosphatase
ISU65_01345	COG2982	Protein involved in outer membrane biogenesis
ISU65_01350	COG2200	EAL domain
ISU65_01355	COG1942	4-Oxalocrotonate Tautomerase
ISU65_01360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU65_01365	COG0612	Peptidase, M16
ISU65_01385	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU65_01390	COG2199	diguanylate cyclase activity
ISU65_01390	COG2200	EAL domain
ISU65_01395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISU65_01400	COG4608	Belongs to the ABC transporter superfamily
ISU65_01405	COG0444	Belongs to the ABC transporter superfamily
ISU65_01410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU65_01415	COG0601	transmembrane transport
ISU65_01420	COG0747	negative chemotaxis
ISU65_01425	COG2831	hemolysin activation secretion protein
ISU65_01440	COG2271	Major facilitator Superfamily
ISU65_01490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU65_01490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU65_01495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU65_01500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISU65_01505	COG3084	Protein conserved in bacteria
ISU65_01515	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISU65_01520	COG3328	transposase activity
ISU65_01535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU65_01545	COG3852	Histidine kinase
ISU65_01550	COG0174	glutamine synthetase
ISU65_01560	COG1011	Hydrolase
ISU65_01585	COG1401	restriction endodeoxyribonuclease activity
ISU65_01640	COG4269	membrane
ISU65_01650	COG2207	Transcriptional regulator
ISU65_01655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU65_01660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU65_01665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU65_01670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_01670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_01670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU65_01720	COG1070	Carbohydrate kinase
ISU65_01725	COG0859	PFAM glycosyl transferase family 9
ISU65_01740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU65_01745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU65_01785	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISU65_01790	COG0456	acetyltransferase
ISU65_01800	COG2823	Periplasmic or secreted lipoprotein
ISU65_01810	COG4667	esterase of the alpha-beta hydrolase superfamily
ISU65_01815	COG0084	hydrolase, TatD family'
ISU65_01820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU65_01845	COG3726	membrane protein affecting hemolysin expression
ISU65_01850	COG0560	Phosphoserine phosphatase
ISU65_01875	COG2885	chlorophyll binding
ISU65_01880	COG2199	diguanylate cyclase activity
ISU65_01895	COG0741	lytic transglycosylase activity
ISU65_01900	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ISU65_01915	COG3708	Transcriptional regulator
ISU65_01915	COG2207	Transcriptional regulator
ISU65_01920	COG3045	CreA protein
ISU65_01925	COG0745	RESPONSE REGULATOR receiver
ISU65_01965	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISU65_01980	COG1584	GPR1 FUN34 yaaH family protein
ISU65_02000	COG0583	DNA-binding transcription factor activity
ISU65_02010	COG0196	riboflavin kinase activity
ISU65_02025	COG1047	Peptidyl-prolyl cis-trans
ISU65_02050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISU65_02055	COG1280	lysine exporter protein (LysE YggA)
ISU65_02060	COG2966	Psort location CytoplasmicMembrane, score
ISU65_02070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISU65_02120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISU65_02125	COG0564	pseudouridine synthase activity
ISU65_02225	COG3047	cAMP biosynthetic process
ISU65_02225	COG2885	chlorophyll binding
ISU65_02245	COG0417	DNA replication proofreading
ISU65_02250	COG0586	Pfam SNARE associated Golgi protein
ISU65_02255	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ISU65_02260	COG1178	ABC-type Fe3 transport system permease component
ISU65_02265	COG4143	(ABC) transporter
ISU65_02275	COG2814	Major facilitator Superfamily
ISU65_02290	COG0473	3-isopropylmalate dehydrogenase activity
ISU65_02315	COG1022	Amp-dependent synthetase and ligase
ISU65_02320	COG0028	Belongs to the TPP enzyme family
ISU65_02335	COG1609	Transcriptional regulator
ISU65_02360	COG3116	cell division
ISU65_02365	COG0768	penicillin binding
ISU65_02370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISU65_02375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISU65_02390	COG0772	Belongs to the SEDS family
ISU65_02410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISU65_02415	COG0849	cell division
ISU65_02420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISU65_02450	COG0494	nUDIX hydrolase
ISU65_02470	COG2259	Doxx family
ISU65_02480	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISU65_02485	COG4575	ribosome binding
ISU65_02500	COG0586	Pfam SNARE associated Golgi protein
ISU65_02515	COG2271	Major facilitator Superfamily
ISU65_02530	COG2721	sulfolactate sulfo-lyase activity
ISU65_02550	COG0673	inositol 2-dehydrogenase activity
ISU65_02555	COG1451	nucleotide metabolic process
ISU65_02570	COG1902	pentaerythritol trinitrate reductase activity
ISU65_02570	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISU65_02575	COG3247	response to pH
ISU65_02590	COG4245	von Willebrand factor, type A
ISU65_02605	COG4245	von Willebrand factor, type A
ISU65_02610	COG2831	hemolysin activation secretion protein
ISU65_02615	COG3210	domain, Protein
ISU65_02645	COG3210	domain, Protein
ISU65_02650	COG3210	domain, Protein
ISU65_02670	COG3842	ATPase activity
ISU65_02675	COG3459	Glycosyltransferase 36 associated
ISU65_02680	COG1609	Transcriptional regulator
ISU65_02685	COG2182	Extracellular solute-binding protein
ISU65_02695	COG0395	ABC-type sugar transport system, permease component
ISU65_02715	COG1289	transmembrane transporter activity
ISU65_02735	COG0436	Aminotransferase
ISU65_02755	COG0251	oxidation-reduction process
ISU65_02825	COG0358	DNA primase activity
ISU65_02830	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISU65_02845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISU65_02860	COG4991	sh3 domain protein
ISU65_02865	COG3025	triphosphatase activity
ISU65_02880	COG0531	amino acid
ISU65_02900	COG3384	dioxygenase
ISU65_02905	COG0754	glutathionylspermidine amidase activity
ISU65_02915	COG1538	Outer membrane efflux protein
ISU65_02920	COG0494	nUDIX hydrolase
ISU65_02925	COG3151	Protein conserved in bacteria
ISU65_02930	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISU65_02935	COG3150	esterase
ISU65_02945	COG0583	DNA-binding transcription factor activity
ISU65_02950	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISU65_02960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISU65_02970	COG2132	Multicopper oxidase
ISU65_02980	COG0656	L-ascorbic acid biosynthetic process
ISU65_02990	COG1979	alcohol dehydrogenase
ISU65_02995	COG2207	Transcriptional regulator
ISU65_03000	COG0586	Pfam SNARE associated Golgi protein
ISU65_03005	COG0626	cystathionine gamma-synthase activity
ISU65_03010	COG0811	peptide transport
ISU65_03015	COG0848	biopolymer transport protein
ISU65_03065	COG4964	Belongs to the GSP D family
ISU65_03070	COG4964	Belongs to the GSP D family
ISU65_03105	COG4592	Periplasmic binding protein
ISU65_03125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU65_03130	COG1684	flagellar biosynthetic protein fliR
ISU65_03135	COG1987	bacterial-type flagellum assembly
ISU65_03160	COG1677	Flagellar hook-basal body complex protein FliE
ISU65_03200	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ISU65_03205	COG1815	bacterial-type flagellum-dependent cell motility
ISU65_03210	COG1558	bacterial-type flagellum-dependent cell motility
ISU65_03215	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ISU65_03220	COG1749	Flagellar hook protein flgE
ISU65_03225	COG4787	bacterial-type flagellum-dependent cell motility
ISU65_03230	COG4786	Flagellar basal body rod
ISU65_03240	COG1706	bacterial-type flagellum-dependent cell motility
ISU65_03270	COG3710	Transcriptional regulator
ISU65_03295	COG0471	metal ion transport
ISU65_03320	COG3501	Rhs element vgr protein
ISU65_03335	COG2610	gluconate transmembrane transporter activity
ISU65_03350	COG1132	(ABC) transporter
ISU65_03355	COG2375	cellular response to nickel ion
ISU65_03355	COG1132	(ABC) transporter
ISU65_03380	COG2226	methyltransferase
ISU65_03380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU65_03380	COG3433	isochorismatase activity
ISU65_03390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU65_03390	COG2226	methyltransferase
ISU65_03390	COG3433	isochorismatase activity
ISU65_03430	COG1459	type II secretion system
ISU65_03435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU65_03440	COG4969	Belongs to the N-Me-Phe pilin family
ISU65_03450	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU65_03455	COG3725	Membrane protein required for beta-lactamase induction
ISU65_03460	COG1113	amino acid transport
ISU65_03465	COG2186	Transcriptional regulator
ISU65_03470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISU65_03475	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU65_03480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU65_03490	COG1049	propionate catabolic process, 2-methylcitrate cycle
ISU65_03500	COG0697	spore germination
ISU65_03520	COG2132	Multicopper oxidase
ISU65_03525	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISU65_03530	COG0288	reversible hydration of carbon dioxide
ISU65_03535	COG1131	(ABC) transporter
ISU65_03540	COG0842	Transport permease protein
ISU65_03565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISU65_03570	COG0617	tRNA 3'-terminal CCA addition
ISU65_03575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISU65_03590	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISU65_03595	COG1643	Atp-dependent helicase
ISU65_03600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISU65_03605	COG1120	ATPase activity
ISU65_03610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU65_03615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_03635	COG2860	membrane
ISU65_03655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU65_03660	COG4999	Histidine kinase
ISU65_03660	COG2205	protein histidine kinase activity
ISU65_03660	COG3437	response regulator, receiver
ISU65_03660	COG3850	Histidine kinase
ISU65_03670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISU65_03675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU65_03680	COG3956	TIGRFAM MazG family protein
ISU65_03700	COG0602	queuosine metabolic process
ISU65_03705	COG0720	synthase
ISU65_03760	COG0529	Catalyzes the synthesis of activated sulfate
ISU65_03800	COG1388	LysM domain
ISU65_03800	COG4942	peptidase
ISU65_03805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISU65_03815	COG0698	ribose 5-phosphate isomerase
ISU65_03820	COG1063	alcohol dehydrogenase
ISU65_03825	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_03830	COG2376	Dihydroxyacetone kinase
ISU65_03845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISU65_03865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_03870	COG1858	cytochrome C peroxidase
ISU65_03880	COG4771	TonB-dependent receptor
ISU65_03890	COG0024	Methionine aminopeptidase
ISU65_03900	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU65_03900	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU65_03905	COG1070	Carbohydrate kinase
ISU65_03910	COG3623	hexulose-6-phosphate isomerase
ISU65_03915	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_03920	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_03925	COG1129	ABC transporter
ISU65_03940	COG1349	DNA-binding transcription factor activity
ISU65_03945	COG0235	Class ii aldolase
ISU65_03950	COG0243	molybdopterin cofactor binding
ISU65_03955	COG0437	4 iron, 4 sulfur cluster binding
ISU65_03960	COG3302	dmso reductase anchor subunit
ISU65_03965	COG3381	protein complex oligomerization
ISU65_03970	COG3038	cytochrome b561
ISU65_03975	COG3783	Cytochrome b(562)
ISU65_03985	COG1879	ABC-type sugar transport system periplasmic component
ISU65_03995	COG1129	ABC transporter
ISU65_04000	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_04005	COG3959	Transketolase, thiamine diphosphate binding domain
ISU65_04010	COG3958	Transketolase
ISU65_04015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU65_04055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISU65_04085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU65_04090	COG1238	metal cluster binding
ISU65_04095	COG2918	glutathione biosynthetic process
ISU65_04110	COG4536	flavin adenine dinucleotide binding
ISU65_04115	COG4137	Cytochrome C assembly protein
ISU65_04120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISU65_04150	COG3137	Salt-induced outer membrane protein
ISU65_04160	COG3279	Response regulator of the LytR AlgR family
ISU65_04165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU65_04170	COG0287	Prephenate dehydrogenase
ISU65_04170	COG1605	Chorismate mutase
ISU65_04200	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISU65_04205	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU65_04210	COG0564	pseudouridine synthase activity
ISU65_04220	COG0542	response to heat
ISU65_04250	COG5544	Lipoprotein
ISU65_04255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISU65_04260	COG0045	succinate-CoA ligase (ADP-forming) activity
ISU65_04260	COG1042	CoA-binding domain protein
ISU65_04260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU65_04265	COG3148	PFAM DTW domain containing protein
ISU65_04270	COG3118	belongs to the thioredoxin family
ISU65_04275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU65_04280	COG2814	Major facilitator Superfamily
ISU65_04285	COG1566	PFAM secretion protein HlyD family protein
ISU65_04290	COG1846	Transcriptional regulator
ISU65_04300	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISU65_04305	COG2814	Major facilitator Superfamily
ISU65_04340	COG0765	amino acid transport
ISU65_04350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU65_04365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU65_04390	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
ISU65_04400	COG1960	acyl-CoA dehydrogenase activity
ISU65_04410	COG0121	glutamine amidotransferase
ISU65_04415	COG3034	peptidoglycan biosynthetic process
ISU65_04425	COG1805	sodium ion transport
ISU65_04430	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU65_04450	COG1477	protein flavinylation
ISU65_04470	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU65_04475	COG0583	DNA-binding transcription factor activity
ISU65_04525	COG2226	methyltransferase
ISU65_04550	COG1940	carbohydrate kinase activity
ISU65_04555	COG0419	ATPase involved in DNA repair
ISU65_04560	COG0420	3'-5' exonuclease activity
ISU65_04565	COG0745	RESPONSE REGULATOR receiver
ISU65_04570	COG5002	protein histidine kinase activity
ISU65_04590	COG0366	Alpha amylase catalytic
ISU65_04610	COG0450	alkyl hydroperoxide reductase
ISU65_04630	COG1862	Preprotein translocase
ISU65_04640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU65_04665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU65_04665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU65_04680	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISU65_04685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISU65_04700	COG0142	geranyltranstransferase activity
ISU65_04715	COG0693	protein deglycase activity
ISU65_04720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISU65_04730	COG2814	Major facilitator Superfamily
ISU65_04740	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISU65_04745	COG1845	cytochrome c oxidase, subunit III
ISU65_04750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISU65_04755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISU65_04765	COG2223	nitrite transmembrane transporter activity
ISU65_04770	COG3056	Lipoprotein
ISU65_04775	COG0271	Belongs to the BolA IbaG family
ISU65_04795	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISU65_04800	COG0776	regulation of translation
ISU65_04805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU65_04810	COG1555	photosystem II stabilization
ISU65_04815	COG0824	Thioesterase
ISU65_04825	COG4533	DNA binding
ISU65_04840	COG1522	sequence-specific DNA binding
ISU65_04845	COG1132	(ABC) transporter
ISU65_04850	COG1132	(ABC) transporter
ISU65_04855	COG0347	Belongs to the P(II) protein family
ISU65_04880	COG1946	Acyl-CoA thioesterase
ISU65_04885	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISU65_04890	COG3695	enzyme binding
ISU65_04915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU65_04925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU65_04930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU65_04935	COG1309	transcriptional regulator
ISU65_04940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISU65_04945	COG3264	Mechanosensitive ion channel
ISU65_04945	COG1196	nuclear chromosome segregation
ISU65_04960	COG2832	Protein of unknown function (DUF454)
ISU65_04970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISU65_05000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU65_05000	COG0543	2 iron, 2 sulfur cluster binding
ISU65_05020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU65_05060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU65_05080	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU65_05085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU65_05090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU65_05090	COG4651	solute:proton antiporter activity
ISU65_05095	COG2223	nitrite transmembrane transporter activity
ISU65_05110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISU65_05115	COG3735	TraB family
ISU65_05120	COG2217	Heavy metal translocating P-type atpase
ISU65_05125	COG0789	Transcriptional regulator
ISU65_05130	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISU65_05135	COG0330	HflC and HflK could
ISU65_05140	COG3118	belongs to the thioredoxin family
ISU65_05145	COG0300	oxidoreductase activity
ISU65_05150	COG2755	lipolytic protein G-D-S-L family
ISU65_05155	COG4181	ATPase activity
ISU65_05160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISU65_05165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISU65_05170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISU65_05180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU65_05195	COG2501	S4 domain
ISU65_05230	COG0582	viral genome integration into host DNA
ISU65_05240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISU65_05245	COG4589	Belongs to the CDS family
ISU65_05255	COG2267	carboxylic ester hydrolase activity
ISU65_05260	COG2453	phosphatase
ISU65_05260	COG0671	phosphoesterase, PA-phosphatase related
ISU65_05290	COG0667	Aldo Keto reductase
ISU65_05295	COG0656	L-ascorbic acid biosynthetic process
ISU65_05305	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU65_05320	COG3328	transposase activity
ISU65_05375	COG3423	Transcriptional regulator
ISU65_05380	COG4953	penicillin-binding protein 1C
ISU65_05390	COG2373	Large extracellular alpha-helical protein
ISU65_05410	COG3962	Belongs to the TPP enzyme family
ISU65_05425	COG1129	ABC transporter
ISU65_05430	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_05435	COG0673	inositol 2-dehydrogenase activity
ISU65_05440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU65_05450	COG3718	enzyme involved in inositol metabolism
ISU65_05460	COG5265	(ABC) transporter
ISU65_05485	COG2197	response regulator
ISU65_05490	COG1278	Cold shock
ISU65_05500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU65_05505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU65_05525	COG1686	Belongs to the peptidase S11 family
ISU65_05530	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU65_05535	COG0772	Belongs to the SEDS family
ISU65_05540	COG0768	penicillin binding
ISU65_05550	COG0799	negative regulation of ribosome biogenesis
ISU65_05560	COG1466	dna polymerase III delta subunit
ISU65_05575	COG2888	peptidyl-tyrosine sulfation
ISU65_05580	COG1126	abc transporter atp-binding protein
ISU65_05585	COG0765	amino acid transport
ISU65_05590	COG0765	amino acid transport
ISU65_05600	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ISU65_05605	COG4535	Mg2 and Co2 transporter CorC
ISU65_05615	COG1702	phosphate starvation-inducible protein PhoH
ISU65_05620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISU65_05625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU65_05660	COG0367	asparagine synthase
ISU65_05665	COG0647	UMP catabolic process
ISU65_05670	COG1846	Transcriptional regulator
ISU65_05670	COG1940	carbohydrate kinase activity
ISU65_05675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISU65_05685	COG1263	PTS System
ISU65_05685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU65_05685	COG2190	(PTS) system
ISU65_05710	COG0735	belongs to the Fur family
ISU65_05725	COG0596	Alpha beta hydrolase
ISU65_05735	COG0582	viral genome integration into host DNA
ISU65_05770	COG2113	Glycine betaine
ISU65_05775	COG4176	ABC-type proline glycine betaine transport system permease component
ISU65_05780	COG4175	Glycine betaine
ISU65_05785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISU65_05825	COG1278	Cold shock
ISU65_05830	COG0747	negative chemotaxis
ISU65_05840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU65_05845	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ISU65_05850	COG1124	(ABC) transporter
ISU65_05855	COG0831	urea catabolic process
ISU65_05880	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISU65_05890	COG4413	Urea transporter
ISU65_05895	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU65_05905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU65_05915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU65_05925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU65_05930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU65_05935	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISU65_05940	COG2169	Transcriptional regulator
ISU65_05940	COG1917	Cupin 2, conserved barrel domain protein
ISU65_05955	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ISU65_05960	COG0033	Phosphoglucomutase
ISU65_05975	COG0745	RESPONSE REGULATOR receiver
ISU65_05980	COG2205	protein histidine kinase activity
ISU65_06015	COG3272	Protein of unknown function (DUF1722)
ISU65_06025	COG5212	phosphodiesterase
ISU65_06030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ISU65_06045	COG1984	allophanate hydrolase subunit 2
ISU65_06090	COG0513	Belongs to the DEAD box helicase family
ISU65_06100	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISU65_06115	COG3026	antisigma factor binding
ISU65_06120	COG3086	response to oxidative stress
ISU65_06155	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISU65_06170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU65_06175	COG1737	Transcriptional regulator
ISU65_06185	COG0560	Phosphoserine phosphatase
ISU65_06230	COG2205	protein histidine kinase activity
ISU65_06235	COG3170	Tfp pilus assembly protein FimV
ISU65_06240	COG2204	response regulator
ISU65_06245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISU65_06245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU65_06250	COG0347	Belongs to the P(II) protein family
ISU65_06275	COG1017	nitric oxide dioxygenase activity
ISU65_06275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU65_06295	COG2814	Major facilitator Superfamily
ISU65_06300	COG3711	transcriptional antiterminator
ISU65_06305	COG3683	transport system, periplasmic component
ISU65_06310	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU65_06330	COG1104	cysteine desulfurase activity
ISU65_06335	COG0822	iron-sulfur transferase activity
ISU65_06355	COG0633	Ferredoxin
ISU65_06360	COG2975	iron-sulfur cluster assembly
ISU65_06385	COG3468	outer membrane autotransporter barrel domain protein
ISU65_06390	COG3468	outer membrane autotransporter barrel domain protein
ISU65_06430	COG2976	Protein conserved in bacteria
ISU65_06435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU65_06450	COG1645	bacterial-type flagellum-dependent swarming motility
ISU65_06460	COG0517	IMP dehydrogenase activity
ISU65_06460	COG0516	GMP reductase activity
ISU65_06505	COG3328	transposase activity
ISU65_06520	COG0351	phosphomethylpyrimidine kinase
ISU65_06545	COG0826	peptidase U32
ISU65_06550	COG3422	double-strand break repair
ISU65_06555	COG0745	RESPONSE REGULATOR receiver
ISU65_06595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISU65_06605	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU65_06610	COG1177	transmembrane transport
ISU65_06615	COG0443	Heat shock 70 kDa protein
ISU65_06620	COG2239	Acts as a magnesium transporter
ISU65_06635	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISU65_06645	COG0581	inorganic phosphate transmembrane transporter activity
ISU65_06660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU65_06665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISU65_06690	COG1393	Belongs to the ArsC family
ISU65_06695	COG4783	chaperone-mediated protein folding
ISU65_06700	COG0628	permease
ISU65_06710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISU65_06715	COG2716	regulation of RNA biosynthetic process
ISU65_06725	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISU65_06740	COG2321	neutral zinc metallopeptidase
ISU65_06760	COG1876	peptidase activity
ISU65_06770	COG1393	Belongs to the ArsC family
ISU65_06785	COG1175	transmembrane transport
ISU65_06790	COG3842	ATPase activity
ISU65_06800	COG3119	arylsulfatase activity
ISU65_06805	COG0641	radical SAM
ISU65_06810	COG1988	membrane-bound metal-dependent
ISU65_06820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU65_06830	COG2197	response regulator
ISU65_06835	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU65_06835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU65_06840	COG3062	negative regulation of establishment of protein localization
ISU65_06850	COG3043	anaerobic respiration
ISU65_06855	COG3005	denitrification pathway
ISU65_06895	COG3111	PFAM Bacterial OB fold (BOF) protein
ISU65_06905	COG2837	iron assimilation
ISU65_06910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISU65_06920	COG4886	Leucine-rich repeat (LRR) protein
ISU65_06930	COG2731	YhcH YjgK YiaL family protein
ISU65_06935	COG1737	Transcriptional regulator
ISU65_06945	COG4150	thiosulfate binding
ISU65_06950	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISU65_06955	COG4208	sulfate ABC transporter
ISU65_06960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISU65_06975	COG0745	RESPONSE REGULATOR receiver
ISU65_06980	COG5002	protein histidine kinase activity
ISU65_06980	COG3850	Histidine kinase
ISU65_06990	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISU65_07010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISU65_07025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU65_07030	COG0745	RESPONSE REGULATOR receiver
ISU65_07035	COG2205	protein histidine kinase activity
ISU65_07055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_07065	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ISU65_07080	COG3530	Putative quorum-sensing-regulated virulence factor
ISU65_07145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU65_07160	COG0667	Aldo Keto reductase
ISU65_07185	COG0436	Aminotransferase
ISU65_07190	COG3038	cytochrome b561
ISU65_07220	COG3381	protein complex oligomerization
ISU65_07225	COG3302	dmso reductase anchor subunit
ISU65_07230	COG0437	4 iron, 4 sulfur cluster binding
ISU65_07235	COG0243	molybdopterin cofactor binding
ISU65_07270	COG2951	lytic endotransglycosylase activity
ISU65_07330	COG3121	Chaperone
ISU65_07335	COG3188	usher protein
ISU65_07340	COG3328	transposase activity
ISU65_07345	COG3188	usher protein
ISU65_07410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISU65_07425	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ISU65_07440	COG1169	isochorismate synthase
ISU65_07450	COG4575	ribosome binding
ISU65_07455	COG0129	dihydroxy-acid dehydratase activity
ISU65_07470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU65_07475	COG1609	Transcriptional regulator
ISU65_07480	COG1649	PFAM Uncharacterised BCR, COG1649
ISU65_07495	COG3265	gluconokinase activity
ISU65_07500	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_07520	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU65_07525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISU65_07535	COG0839	Belongs to the complex I subunit 6 family
ISU65_07550	COG1034	ATP synthesis coupled electron transport
ISU65_07570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU65_07580	COG0583	DNA-binding transcription factor activity
ISU65_07585	COG0436	Aminotransferase
ISU65_07600	COG0471	metal ion transport
ISU65_07600	COG0490	domain, Protein
ISU65_07605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU65_07625	COG0280	phosphate acetyltransferase
ISU65_07625	COG0857	belongs to the CobB CobQ family
ISU65_07630	COG1609	Transcriptional regulator
ISU65_07645	COG3328	transposase activity
ISU65_07650	COG3037	sugar-specific permease SgaT UlaA
ISU65_07655	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISU65_07660	COG0622	Phosphoesterase
ISU65_07670	COG1090	epimerase
ISU65_07675	COG4598	ABC transporter
ISU65_07680	COG4160	amino acid transport
ISU65_07685	COG4215	(ABC) transporter
ISU65_07690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_07700	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISU65_07705	COG1286	toxin biosynthetic process
ISU65_07710	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISU65_07715	COG0285	dihydrofolate synthase activity
ISU65_07725	COG0586	Pfam SNARE associated Golgi protein
ISU65_07735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU65_07750	COG0697	spore germination
ISU65_07765	COG1794	racemase activity, acting on amino acids and derivatives
ISU65_07770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU65_07785	COG3101	peptidyl-lysine hydroxylation
ISU65_07790	COG0730	response to heat
ISU65_07805	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU65_07815	COG2062	phosphohistidine phosphatase, SixA
ISU65_07830	COG3691	Protein conserved in bacteria
ISU65_07845	COG3088	subunit of a heme lyase
ISU65_07845	COG4235	cytochrome complex assembly
ISU65_07850	COG3088	subunit of a heme lyase
ISU65_07850	COG4235	cytochrome complex assembly
ISU65_07855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU65_07860	COG1138	Cytochrome C-type biogenesis protein
ISU65_07870	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU65_07875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU65_07880	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU65_07900	COG1704	LemA family
ISU65_07910	COG2824	Alkylphosphonate utilization operon protein PhnA
ISU65_07970	COG1126	abc transporter atp-binding protein
ISU65_07975	COG0765	amino acid transport
ISU65_07980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_08010	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISU65_08030	COG1063	alcohol dehydrogenase
ISU65_08035	COG1879	ABC-type sugar transport system periplasmic component
ISU65_08040	COG1129	ABC transporter
ISU65_08045	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_08050	COG1609	Transcriptional regulator
ISU65_08055	COG0583	DNA-binding transcription factor activity
ISU65_08060	COG0473	3-isopropylmalate dehydrogenase activity
ISU65_08070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISU65_08080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU65_08085	COG2831	hemolysin activation secretion protein
ISU65_08130	COG3210	domain, Protein
ISU65_08140	COG3842	ATPase activity
ISU65_08150	COG1609	Transcriptional regulator
ISU65_08165	COG0395	ABC-type sugar transport system, permease component
ISU65_08170	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ISU65_08195	COG0668	transmembrane transport
ISU65_08200	COG1518	maintenance of DNA repeat elements
ISU65_08205	COG1203	CRISPR-associated helicase, Cas3
ISU65_08230	COG0667	Aldo Keto reductase
ISU65_08240	COG0477	Major facilitator Superfamily
ISU65_08250	COG0583	DNA-binding transcription factor activity
ISU65_08255	COG2771	luxR family
ISU65_08260	COG3916	Acyl-homoserine-lactone synthase
ISU65_08280	COG0628	permease
ISU65_08300	COG3328	transposase activity
ISU65_08310	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISU65_08330	COG3328	transposase activity
ISU65_08335	COG1530	ribonuclease E activity
ISU65_08340	COG0564	pseudouridine synthase activity
ISU65_08345	COG0424	maF-like protein
ISU65_08350	COG1399	metal-binding, possibly nucleic acid-binding protein
ISU65_08355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISU65_08385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU65_08395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU65_08400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISU65_08410	COG0470	DNA polymerase III
ISU65_08415	COG0084	hydrolase, TatD family'
ISU65_08420	COG1263	PTS System
ISU65_08420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU65_08445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISU65_08450	COG0537	adenosine 5'-monophosphoramidase activity
ISU65_08455	COG5633	Lipoprotein
ISU65_08470	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU65_08480	COG1252	NADH dehydrogenase
ISU65_08495	COG3328	transposase activity
ISU65_08500	COG3134	Outer membrane lipoprotein
ISU65_08505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISU65_08510	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU65_08520	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU65_08525	COG1940	carbohydrate kinase activity
ISU65_08545	COG2850	peptidyl-arginine hydroxylation
ISU65_08555	COG0745	RESPONSE REGULATOR receiver
ISU65_08565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISU65_08585	COG1187	pseudouridine synthase activity
ISU65_08590	COG0538	isocitrate dehydrogenase activity
ISU65_08605	COG0840	transmembrane signaling receptor activity
ISU65_08610	COG0702	epimerase
ISU65_08615	COG1733	regulation of RNA biosynthetic process
ISU65_08640	COG1522	sequence-specific DNA binding
ISU65_08655	COG3321	synthase
ISU65_08655	COG0604	alcohol dehydrogenase
ISU65_08655	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_08680	COG1285	pathogenesis
ISU65_08705	COG1360	Flagellar Motor Protein
ISU65_08710	COG2198	Histidine kinase
ISU65_08710	COG0643	Histidine kinase
ISU65_08715	COG0835	chemotaxis
ISU65_08720	COG2271	Major facilitator Superfamily
ISU65_08725	COG0251	oxidation-reduction process
ISU65_08735	COG2964	Protein conserved in bacteria
ISU65_08755	COG0840	transmembrane signaling receptor activity
ISU65_08760	COG0840	transmembrane signaling receptor activity
ISU65_08765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ISU65_08775	COG0745	RESPONSE REGULATOR receiver
ISU65_08780	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISU65_08785	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU65_08790	COG5295	Hep Hag repeat protein
ISU65_08800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISU65_08855	COG3121	Chaperone
ISU65_08875	COG3008	intermembrane lipid transfer
ISU65_08880	COG2995	paraquat-inducible protein a
ISU65_08885	COG1956	GAF domain-containing protein
ISU65_08895	COG0793	Belongs to the peptidase S41A family
ISU65_08905	COG3539	Fimbrial protein
ISU65_08910	COG3121	Chaperone
ISU65_08925	COG3121	Chaperone
ISU65_08930	COG2814	Major facilitator Superfamily
ISU65_08935	COG0823	Involved in the tonB-independent uptake of proteins
ISU65_08945	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU65_08950	COG1823	symporter activity
ISU65_08955	COG1988	membrane-bound metal-dependent
ISU65_08960	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU65_08965	COG1653	transport
ISU65_08975	COG0395	ABC-type sugar transport system, permease component
ISU65_08980	COG1175	transmembrane transport
ISU65_08990	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_09000	COG1917	Cupin 2, conserved barrel domain protein
ISU65_09005	COG3328	transposase activity
ISU65_09010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU65_09020	COG3001	Fructosamine kinase
ISU65_09030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU65_09035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU65_09040	COG1121	(ABC) transporter
ISU65_09045	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISU65_09065	COG4249	Peptidase C14 caspase catalytic subunit p20
ISU65_09100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISU65_09100	COG0072	phenylalanine-tRNA ligase activity
ISU65_09105	COG0776	regulation of translation
ISU65_09120	COG0386	Belongs to the glutathione peroxidase family
ISU65_09170	COG0791	NLP P60 protein
ISU65_09195	COG0574	Belongs to the PEP-utilizing enzyme family
ISU65_09195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU65_09205	COG0628	permease
ISU65_09210	COG0247	lactate metabolic process
ISU65_09210	COG0277	FAD linked oxidase domain protein
ISU65_09215	COG2050	protein possibly involved in aromatic compounds catabolism
ISU65_09220	COG0316	Belongs to the HesB IscA family
ISU65_09225	COG0719	Fe-S assembly protein
ISU65_09230	COG0396	ATPase activity
ISU65_09235	COG0719	Fe-S assembly protein
ISU65_09250	COG1376	ErfK ybiS ycfS ynhG family protein
ISU65_09250	COG1388	LysM domain
ISU65_09305	COG0307	riboflavin synthase, alpha
ISU65_09310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISU65_09315	COG2814	Major facilitator Superfamily
ISU65_09320	COG0583	DNA-binding transcription factor activity
ISU65_09340	COG0791	NLP P60 protein
ISU65_09345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISU65_09355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISU65_09360	COG0346	lactoylglutathione lyase activity
ISU65_09370	COG1309	transcriptional regulator
ISU65_09375	COG2194	sulfuric ester hydrolase activity
ISU65_09385	COG3133	Outer membrane lipoprotein
ISU65_09395	COG3895	Periplasmic Protein
ISU65_09415	COG0625	glutathione transferase activity
ISU65_09430	COG3104	oligopeptide transport
ISU65_09435	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU65_09435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU65_09440	COG4172	Belongs to the ABC transporter superfamily
ISU65_09450	COG4171	peptide transport system, permease
ISU65_09455	COG4168	peptide transport system, permease
ISU65_09460	COG4166	transmembrane transport
ISU65_09470	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISU65_09475	COG1842	Phage shock protein A
ISU65_09485	COG1983	PspC domain protein
ISU65_09495	COG3106	COG3106 Predicted ATPase
ISU65_09505	COG5654	RES domain protein
ISU65_09510	COG5642	Protein of unknown function (DUF2384)
ISU65_09525	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISU65_09530	COG4948	Mandelate Racemase Muconate Lactonizing
ISU65_09535	COG2866	Carboxypeptidase
ISU65_09540	COG4166	transmembrane transport
ISU65_09555	COG0657	acetylesterase activity
ISU65_09565	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISU65_09565	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISU65_09565	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU65_09565	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISU65_09575	COG1285	pathogenesis
ISU65_09580	COG3042	response to heat
ISU65_09585	COG3187	Heat shock protein
ISU65_09590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU65_09595	COG2911	Protein conserved in bacteria
ISU65_09605	COG3784	Protein of unknown function (DUF1318)
ISU65_09610	COG0246	Mannitol dehydrogenase
ISU65_09615	COG2390	Transcriptional regulator
ISU65_09625	COG1643	Atp-dependent helicase
ISU65_09640	COG3591	Belongs to the peptidase S1B family
ISU65_09680	COG1012	belongs to the aldehyde dehydrogenase family
ISU65_09680	COG1454	alcohol dehydrogenase
ISU65_09685	COG2095	MarC family integral membrane protein
ISU65_09695	COG0601	transmembrane transport
ISU65_09700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU65_09705	COG0444	Belongs to the ABC transporter superfamily
ISU65_09710	COG4608	Belongs to the ABC transporter superfamily
ISU65_09755	COG2350	Protein conserved in bacteria
ISU65_09760	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ISU65_09765	COG3328	transposase activity
ISU65_09800	COG3047	cAMP biosynthetic process
ISU65_09820	COG0134	indole-3-glycerol-phosphate synthase activity
ISU65_09820	COG0135	phosphoribosylanthranilate isomerase activity
ISU65_09830	COG0512	Glutamine amidotransferase of anthranilate synthase
ISU65_09850	COG0009	L-threonylcarbamoyladenylate synthase
ISU65_09855	COG1187	pseudouridine synthase activity
ISU65_09865	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_09870	COG0616	signal peptide processing
ISU65_09890	COG0583	DNA-binding transcription factor activity
ISU65_09910	COG0671	phosphoesterase, PA-phosphatase related
ISU65_09915	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISU65_09920	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISU65_09935	COG0023	Translation Initiation Factor
ISU65_09955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISU65_09960	COG2879	small protein
ISU65_09965	COG1966	Carbon starvation protein
ISU65_09975	COG2271	Major facilitator Superfamily
ISU65_09980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU65_09985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISU65_09995	COG4659	FMN binding
ISU65_10000	COG4658	electron transport chain
ISU65_10005	COG2207	Transcriptional regulator
ISU65_10005	COG3708	Transcriptional regulator
ISU65_10035	COG1132	(ABC) transporter
ISU65_10045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU65_10050	COG2274	protein secretion by the type I secretion system
ISU65_10065	COG1879	ABC-type sugar transport system periplasmic component
ISU65_10070	COG1129	ABC transporter
ISU65_10075	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_10085	COG0673	inositol 2-dehydrogenase activity
ISU65_10090	COG0385	Bile acid
ISU65_10100	COG5339	Protein conserved in bacteria
ISU65_10110	COG0114	fumarate hydratase activity
ISU65_10120	COG2814	Major facilitator Superfamily
ISU65_10125	COG0583	DNA-binding transcription factor activity
ISU65_10130	COG1940	carbohydrate kinase activity
ISU65_10135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISU65_10140	COG0038	chloride channel
ISU65_10145	COG1609	Transcriptional regulator
ISU65_10165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU65_10175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISU65_10205	COG0028	Belongs to the TPP enzyme family
ISU65_10210	COG0440	acetolactate synthase activity
ISU65_10215	COG1011	Hydrolase
ISU65_10235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU65_10240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISU65_10245	COG0589	response to stress
ISU65_10250	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISU65_10255	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISU65_10265	COG0531	amino acid
ISU65_10275	COG0745	RESPONSE REGULATOR receiver
ISU65_10280	COG2205	protein histidine kinase activity
ISU65_10285	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISU65_10320	COG0745	RESPONSE REGULATOR receiver
ISU65_10330	COG0788	formyltetrahydrofolate deformylase activity
ISU65_10335	COG3328	transposase activity
ISU65_10355	COG0583	DNA-binding transcription factor activity
ISU65_10360	COG0708	Exodeoxyribonuclease III
ISU65_10365	COG0494	nUDIX hydrolase
ISU65_10375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISU65_10380	COG0709	Synthesizes selenophosphate from selenide and ATP
ISU65_10385	COG0778	Nitroreductase
ISU65_10390	COG0616	signal peptide processing
ISU65_10395	COG0252	asparaginase activity
ISU65_10400	COG1335	isochorismatase
ISU65_10405	COG3139	Protein of unknown function (DUF1315)
ISU65_10425	COG3713	MltA-interacting MipA family protein
ISU65_10430	COG2766	serine protein kinase
ISU65_10445	COG0583	DNA-binding transcription factor activity
ISU65_10455	COG2814	Major facilitator Superfamily
ISU65_10465	COG2719	SpoVR family
ISU65_10495	COG1104	cysteine desulfurase activity
ISU65_10505	COG3328	transposase activity
ISU65_10665	COG3328	transposase activity
ISU65_10765	COG0582	viral genome integration into host DNA
ISU65_10775	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISU65_10780	COG2951	lytic endotransglycosylase activity
ISU65_10795	COG2894	cell division
ISU65_10800	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISU65_10805	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ISU65_10810	COG0318	PFAM AMP-dependent synthetase and ligase
ISU65_10830	COG1199	ATP-dependent helicase activity
ISU65_10835	COG0251	oxidation-reduction process
ISU65_10850	COG0800	Aldolase
ISU65_10855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISU65_10860	COG1737	Transcriptional regulator
ISU65_10865	COG0469	pyruvate kinase activity
ISU65_10875	COG1560	Kdo2-lipid A biosynthetic process
ISU65_10880	COG0739	heme binding
ISU65_10885	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISU65_10895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU65_10920	COG0494	nUDIX hydrolase
ISU65_10930	COG1801	Protein of unknown function DUF72
ISU65_10935	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISU65_10955	COG3102	Protein conserved in bacteria
ISU65_10975	COG0728	peptidoglycan biosynthetic process
ISU65_10985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU65_11000	COG3381	protein complex oligomerization
ISU65_11015	COG1940	carbohydrate kinase activity
ISU65_11020	COG0584	glycerophosphoryl diester phosphodiesterase
ISU65_11040	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU65_11045	COG3833	ABC-type maltose transport systems, permease component
ISU65_11085	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU65_11110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISU65_11125	COG0012	GTP binding
ISU65_11175	COG5002	protein histidine kinase activity
ISU65_11220	COG0500	methyltransferase
ISU65_11240	COG3328	transposase activity
ISU65_11285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU65_11290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU65_11295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU65_11310	COG0402	S-adenosylhomocysteine deaminase activity
ISU65_11375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISU65_11385	COG3850	Histidine kinase
ISU65_11390	COG0387	Pfam Sodium calcium exchanger
ISU65_11395	COG1702	phosphate starvation-inducible protein PhoH
ISU65_11410	COG3658	cytochrome
ISU65_11415	COG1215	transferase activity, transferring glycosyl groups
ISU65_11420	COG1649	PFAM Uncharacterised BCR, COG1649
ISU65_11420	COG0726	polysaccharide deacetylase
ISU65_11425	COG0457	Tetratricopeptide repeat
ISU65_11430	COG0006	proline dipeptidase activity
ISU65_11450	COG0577	efflux transmembrane transporter activity
ISU65_11450	COG1136	(ABC) transporter
ISU65_11475	COG0672	)-iron permease
ISU65_11490	COG2066	Belongs to the glutaminase family
ISU65_11500	COG1349	DNA-binding transcription factor activity
ISU65_11510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISU65_11515	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU65_11530	COG2814	Major facilitator Superfamily
ISU65_11555	COG2030	dehydratase
ISU65_11560	COG0427	acetyl-CoA hydrolase
ISU65_11570	COG2205	protein histidine kinase activity
ISU65_11570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_11610	COG3121	Chaperone
ISU65_11620	COG0582	viral genome integration into host DNA
ISU65_11625	COG1169	isochorismate synthase
ISU65_11630	COG2814	Major facilitator Superfamily
ISU65_11635	COG1132	(ABC) transporter
ISU65_11650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU65_11650	COG2226	methyltransferase
ISU65_11650	COG3433	isochorismatase activity
ISU65_11670	COG1021	2,3-dihydroxybenzoate-AMP ligase
ISU65_11675	COG4771	TonB-dependent receptor
ISU65_11735	COG3842	ATPase activity
ISU65_11740	COG0395	ABC-type sugar transport system, permease component
ISU65_11745	COG1175	transmembrane transport
ISU65_11755	COG0673	inositol 2-dehydrogenase activity
ISU65_11760	COG2188	Transcriptional regulator
ISU65_11885	COG2197	response regulator
ISU65_11895	COG3136	membrane protein required for alginate biosynthesis
ISU65_11915	COG1113	amino acid transport
ISU65_11935	COG2822	iron ion transport
ISU65_11940	COG0672	)-iron permease
ISU65_11955	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU65_11955	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU65_11955	COG0506	proline dehydrogenase activity
ISU65_11970	COG1126	abc transporter atp-binding protein
ISU65_11975	COG0765	amino acid transport
ISU65_11980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_11995	COG1191	sigma factor activity
ISU65_12025	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ISU65_12030	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISU65_12035	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISU65_12055	COG1677	Flagellar hook-basal body complex protein FliE
ISU65_12075	COG1157	protein secretion by the type III secretion system
ISU65_12090	COG1580	Controls the rotational direction of flagella during chemotaxis
ISU65_12115	COG1987	bacterial-type flagellum assembly
ISU65_12135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU65_12140	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_12145	COG1129	ABC transporter
ISU65_12155	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_12160	COG3347	Dehydrogenase
ISU65_12160	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_12165	COG2390	Transcriptional regulator
ISU65_12175	COG1256	bacterial-type flagellum assembly
ISU65_12215	COG1558	bacterial-type flagellum-dependent cell motility
ISU65_12220	COG1815	bacterial-type flagellum-dependent cell motility
ISU65_12230	COG2747	anti-sigma28 factor FlgM
ISU65_12235	COG3418	PFAM FlgN family protein
ISU65_12260	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU65_12265	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU65_12290	COG2372	response to copper ion
ISU65_12295	COG1528	Iron-storage protein
ISU65_12310	COG1770	oligopeptidase
ISU65_12325	COG3141	response to X-ray
ISU65_12330	COG0513	Belongs to the DEAD box helicase family
ISU65_12355	COG1760	l-serine dehydratase
ISU65_12360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISU65_12365	COG2368	4-hydroxyphenylacetate
ISU65_12380	COG3971	2-oxopent-4-enoate hydratase activity
ISU65_12390	COG3384	dioxygenase
ISU65_12395	COG1012	belongs to the aldehyde dehydrogenase family
ISU65_12410	COG1846	Transcriptional regulator
ISU65_12415	COG1253	flavin adenine dinucleotide binding
ISU65_12420	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_12420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU65_12425	COG3715	PTS system
ISU65_12430	COG3716	PTS system mannose fructose sorbose family IID component
ISU65_12460	COG2226	methyltransferase
ISU65_12465	COG1496	oxidoreductase activity
ISU65_12485	COG1113	amino acid transport
ISU65_12520	COG2207	Transcriptional regulator
ISU65_12530	COG1132	(ABC) transporter
ISU65_12575	COG3328	transposase activity
ISU65_12580	COG2223	nitrite transmembrane transporter activity
ISU65_12600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISU65_12625	COG3122	Protein conserved in bacteria
ISU65_12645	COG0534	Mate efflux family protein
ISU65_12660	COG4948	Mandelate Racemase Muconate Lactonizing
ISU65_12670	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_12675	COG3011	Protein conserved in bacteria
ISU65_12680	COG2271	Major facilitator Superfamily
ISU65_12685	COG1470	cell adhesion involved in biofilm formation
ISU65_12685	COG1388	LysM domain
ISU65_12690	COG3328	transposase activity
ISU65_12705	COG2925	Exonuclease
ISU65_12715	COG0531	amino acid
ISU65_12720	COG0371	Dehydrogenase
ISU65_12725	COG1129	ABC transporter
ISU65_12730	COG1129	ABC transporter
ISU65_12735	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_12750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU65_12765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISU65_12775	COG0131	Imidazoleglycerol-phosphate dehydratase
ISU65_12775	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU65_12795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISU65_12795	COG0140	phosphoribosyl-ATP diphosphatase activity
ISU65_12805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU65_12810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU65_12825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU65_12830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_12835	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_12840	COG1120	ATPase activity
ISU65_12855	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ISU65_12860	COG0076	glutamate decarboxylase activity
ISU65_12865	COG4114	ferric iron reductase
ISU65_12870	COG1253	flavin adenine dinucleotide binding
ISU65_12875	COG2982	Protein involved in outer membrane biogenesis
ISU65_12890	COG0489	protein tyrosine kinase activity
ISU65_12920	COG2814	Major facilitator Superfamily
ISU65_12930	COG1346	cytolysis
ISU65_12945	COG2949	membrane
ISU65_12950	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISU65_12965	COG2311	Membrane
ISU65_12975	COG0477	Major facilitator Superfamily
ISU65_12980	COG0583	DNA-binding transcription factor activity
ISU65_13010	COG1136	(ABC) transporter
ISU65_13020	COG0303	'Molybdopterin
ISU65_13030	COG3328	transposase activity
ISU65_13040	COG0488	(ABC) transporter
ISU65_13170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISU65_13175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISU65_13185	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_13190	COG1024	Enoyl-CoA hydratase
ISU65_13200	COG3425	synthase
ISU65_13205	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_13210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU65_13215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISU65_13225	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_13250	COG2920	part of a sulfur-relay system
ISU65_13270	COG1832	CoA-binding protein
ISU65_13285	COG0210	DNA helicase
ISU65_13290	COG3304	Inner membrane component domain
ISU65_13295	COG1289	transmembrane transporter activity
ISU65_13300	COG3070	regulator of competence-specific genes
ISU65_13325	COG1067	ATP-dependent peptidase activity
ISU65_13365	COG3130	regulation of translation
ISU65_13370	COG3009	Protein conserved in bacteria
ISU65_13375	COG3008	intermembrane lipid transfer
ISU65_13375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU65_13380	COG2995	paraquat-inducible protein a
ISU65_13385	COG0488	(ABC) transporter
ISU65_13395	COG3217	Mosc domain protein beta barrel domain protein
ISU65_13395	COG0633	Ferredoxin
ISU65_13410	COG0308	aminopeptidase N
ISU65_13430	COG1448	Aminotransferase
ISU65_13440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU65_13445	COG3108	Peptidase M15
ISU65_13450	COG2989	Protein conserved in bacteria
ISU65_13475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISU65_13480	COG3173	Aminoglycoside phosphotransferase
ISU65_13495	COG1278	Cold shock
ISU65_13500	COG5383	Protein conserved in bacteria
ISU65_13515	COG0658	competence protein
ISU65_13515	COG2333	competence protein COMEC
ISU65_13525	COG0539	negative regulation of cytoplasmic translation
ISU65_13550	COG5295	Hep Hag repeat protein
ISU65_13550	COG5295	Hep Hag repeat protein
ISU65_13555	COG0252	asparaginase activity
ISU65_13560	COG1944	ATP diphosphatase activity
ISU65_13565	COG2116	formate transmembrane transporter activity
ISU65_13570	COG1882	Formate acetyltransferase
ISU65_13580	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISU65_13610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISU65_13620	COG3107	peptidoglycan biosynthetic process
ISU65_13620	COG1674	ftsk spoiiie
ISU65_13630	COG0492	ferredoxin-NADP+ reductase activity
ISU65_13640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISU65_13650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ISU65_13660	COG0542	response to heat
ISU65_13670	COG1278	Cold shock
ISU65_13680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU65_13685	COG2990	Protein conserved in bacteria
ISU65_13690	COG3593	DNA synthesis involved in DNA repair
ISU65_13695	COG2431	L-lysine efflux transmembrane transporter activity
ISU65_13705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU65_13710	COG0028	Belongs to the TPP enzyme family
ISU65_13720	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISU65_13725	COG0702	epimerase
ISU65_13730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU65_13740	COG1605	Chorismate mutase
ISU65_13745	COG1126	abc transporter atp-binding protein
ISU65_13750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_13755	COG4215	(ABC) transporter
ISU65_13760	COG4160	amino acid transport
ISU65_13785	COG1120	ATPase activity
ISU65_13790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_13795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_13820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_13835	COG1177	transmembrane transport
ISU65_13840	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU65_13845	COG3842	ATPase activity
ISU65_13850	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISU65_13880	COG0671	phosphoesterase, PA-phosphatase related
ISU65_13890	COG1349	DNA-binding transcription factor activity
ISU65_13895	COG0814	amino acid
ISU65_13900	COG1686	Belongs to the peptidase S11 family
ISU65_13905	COG2011	ABC-type metal ion transport system permease component
ISU65_13930	COG0625	glutathione transferase activity
ISU65_13935	COG4771	TonB-dependent receptor
ISU65_13945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_13955	COG0833	amino acid
ISU65_13960	COG0583	DNA-binding transcription factor activity
ISU65_13965	COG2855	membrane
ISU65_13975	COG3188	usher protein
ISU65_13980	COG3121	Chaperone
ISU65_13995	COG3710	Transcriptional regulator
ISU65_14000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU65_14000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU65_14000	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISU65_14005	COG1105	Belongs to the carbohydrate kinase PfkB family
ISU65_14015	COG0494	nUDIX hydrolase
ISU65_14025	COG1129	ABC transporter
ISU65_14075	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_14100	COG0246	Mannitol dehydrogenase
ISU65_14105	COG2186	Transcriptional regulator
ISU65_14110	COG0523	cobalamin synthesis protein
ISU65_14115	COG0671	phosphoesterase, PA-phosphatase related
ISU65_14120	COG0791	NLP P60 protein
ISU65_14125	COG2200	EAL domain
ISU65_14130	COG4166	transmembrane transport
ISU65_14135	COG4174	ABC transporter (Permease)
ISU65_14140	COG4239	(ABC) transporter, permease
ISU65_14145	COG4172	Belongs to the ABC transporter superfamily
ISU65_14155	COG2814	Major facilitator Superfamily
ISU65_14160	COG1187	pseudouridine synthase activity
ISU65_14165	COG1061	Type III restriction enzyme res subunit
ISU65_14185	COG3082	Protein of unknown function (DUF1414)
ISU65_14190	COG3083	sulfuric ester hydrolase activity
ISU65_14205	COG3157	Type VI secretion system effector, Hcp
ISU65_14225	COG2723	6-phospho-beta-galactosidase activity
ISU65_14230	COG1737	Transcriptional regulator
ISU65_14250	COG3299	homolog of phage Mu protein gp47
ISU65_14290	COG4386	tail sheath protein
ISU65_14310	COG3622	Belongs to the hyi family
ISU65_14315	COG1349	DNA-binding transcription factor activity
ISU65_14325	COG3395	kinase activity
ISU65_14365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISU65_14390	COG2223	nitrite transmembrane transporter activity
ISU65_14395	COG2198	Histidine kinase
ISU65_14395	COG0642	Histidine kinase
ISU65_14400	COG2198	Histidine kinase
ISU65_14400	COG0642	Histidine kinase
ISU65_14410	COG0784	Response regulator, receiver
ISU65_14410	COG2205	protein histidine kinase activity
ISU65_14435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU65_14450	COG0814	amino acid
ISU65_14475	COG0697	spore germination
ISU65_14485	COG1982	Orn Lys Arg decarboxylase major
ISU65_14490	COG0531	amino acid
ISU65_14495	COG1174	glycine betaine transport
ISU65_14500	COG1125	glycine betaine transport
ISU65_14505	COG1174	glycine betaine transport
ISU65_14515	COG2897	thiosulfate sulfurtransferase activity
ISU65_14535	COG1122	ATPase activity
ISU65_14555	COG4807	Protein conserved in bacteria
ISU65_14570	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISU65_14580	COG2261	transglycosylase associated protein
ISU65_14600	COG0277	FAD linked oxidase domain protein
ISU65_14605	COG1686	Belongs to the peptidase S11 family
ISU65_14615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU65_14630	COG0670	Belongs to the BI1 family
ISU65_14635	COG0314	molybdopterin synthase activity
ISU65_14640	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISU65_14650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISU65_14655	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ISU65_14660	COG4628	conserved protein (DUF2132)
ISU65_14670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISU65_14680	COG2226	methyltransferase
ISU65_14705	COG0561	phosphatase activity
ISU65_14715	COG4149	molybdate abc transporter
ISU65_14720	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISU65_14730	COG2005	Transcriptional regulator
ISU65_14730	COG3585	molybdate ion transport
ISU65_14735	COG1119	ATPase activity
ISU65_14745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISU65_14750	COG1085	galactose-1-phosphate uridylyltransferase
ISU65_14765	COG2017	converts alpha-aldose to the beta-anomer
ISU65_14780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU65_14785	COG1230	cation diffusion facilitator family transporter
ISU65_14815	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISU65_14820	COG2885	chlorophyll binding
ISU65_14830	COG3064	Membrane
ISU65_14830	COG3064	Membrane
ISU65_14835	COG0848	biopolymer transport protein
ISU65_14840	COG0811	peptide transport
ISU65_14845	COG0824	Thioesterase
ISU65_14850	COG3790	cyd operon protein YbgE
ISU65_14855	COG4890	Cyd operon protein YbgT
ISU65_14860	COG1294	oxidase, subunit
ISU65_14865	COG1271	oxidase subunit
ISU65_14870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISU65_14880	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU65_14885	COG0567	Dehydrogenase, E1 component
ISU65_14895	COG1053	succinate dehydrogenase
ISU65_14900	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISU65_14905	COG2009	succinate dehydrogenase
ISU65_14920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISU65_14925	COG0497	DNA recombination
ISU65_14930	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU65_14940	COG2867	negative regulation of translational initiation
ISU65_14960	COG0582	viral genome integration into host DNA
ISU65_15010	COG3657	addiction module killer protein
ISU65_15035	COG1953	Uracil, thiamine, allantoin
ISU65_15055	COG2226	methyltransferase
ISU65_15060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU65_15065	COG1388	LysM domain
ISU65_15065	COG0741	lytic transglycosylase activity
ISU65_15080	COG0656	L-ascorbic acid biosynthetic process
ISU65_15110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU65_15120	COG2011	ABC-type metal ion transport system permease component
ISU65_15125	COG1464	Belongs to the NlpA lipoprotein family
ISU65_15135	COG1720	tRNA m6t6A37 methyltransferase activity
ISU65_15145	COG3015	lipoprotein NlpE involved in copper resistance
ISU65_15155	COG4681	YaeQ
ISU65_15165	COG4568	rho-dependent transcription termination
ISU65_15175	COG0037	tRNA processing
ISU65_15180	COG0346	lactoylglutathione lyase activity
ISU65_15190	COG0587	DNA-directed DNA polymerase activity
ISU65_15215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU65_15230	COG0750	zinc metalloprotease
ISU65_15235	COG0575	Belongs to the CDS family
ISU65_15295	COG0564	pseudouridine synthase activity
ISU65_15300	COG3098	single-species biofilm formation
ISU65_15320	COG1611	Belongs to the LOG family
ISU65_15355	COG2944	sequence-specific DNA binding
ISU65_15445	COG1695	Transcriptional regulator
ISU65_15450	COG0791	NLP P60 protein
ISU65_15460	COG1879	ABC-type sugar transport system periplasmic component
ISU65_15465	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_15470	COG1129	ABC transporter
ISU65_15480	COG2182	Extracellular solute-binding protein
ISU65_15485	COG1175	transmembrane transport
ISU65_15490	COG3833	ABC-type maltose transport systems, permease component
ISU65_15495	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISU65_15500	COG1874	Beta-galactosidase
ISU65_15505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU65_15505	COG1263	PTS System
ISU65_15525	COG2271	Major facilitator Superfamily
ISU65_15550	COG3119	arylsulfatase activity
ISU65_15555	COG0641	radical SAM
ISU65_15565	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_15575	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_15580	COG3716	PTS system mannose fructose sorbose family IID component
ISU65_15585	COG3715	PTS system
ISU65_15590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU65_15595	COG2222	sugar isomerase
ISU65_15605	COG1349	DNA-binding transcription factor activity
ISU65_15610	COG3119	arylsulfatase activity
ISU65_15650	COG0288	reversible hydration of carbon dioxide
ISU65_15670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU65_15690	COG2165	general secretion pathway protein
ISU65_15735	COG0840	transmembrane signaling receptor activity
ISU65_15750	COG0583	DNA-binding transcription factor activity
ISU65_15755	COG2814	Major facilitator Superfamily
ISU65_15760	COG0583	DNA-binding transcription factor activity
ISU65_15770	COG1609	Transcriptional regulator
ISU65_15800	COG0667	Aldo Keto reductase
ISU65_15850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISU65_15860	COG1074	ATP-dependent DNA helicase activity
ISU65_15865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISU65_15875	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU65_15890	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISU65_15895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISU65_15900	COG2166	iron-sulfur cluster assembly
ISU65_15905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISU65_15915	COG0583	DNA-binding transcription factor activity
ISU65_15920	COG2363	Small membrane protein
ISU65_15950	COG4771	TonB-dependent receptor
ISU65_15955	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU65_15960	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISU65_16005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU65_16015	COG5001	Diguanylate cyclase
ISU65_16025	COG2211	Major facilitator Superfamily
ISU65_16075	COG2771	luxR family
ISU65_16080	COG3916	Acyl-homoserine-lactone synthase
ISU65_16200	COG1982	Orn Lys Arg decarboxylase major
ISU65_16205	COG1879	ABC-type sugar transport system periplasmic component
ISU65_16210	COG1129	ABC transporter
ISU65_16215	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_16220	COG4774	siderophore transport
ISU65_16240	COG1194	a g-specific adenine glycosylase
ISU65_16250	COG3171	Protein conserved in bacteria
ISU65_16270	COG1073	alpha beta
ISU65_16270	COG3064	Membrane
ISU65_16270	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ISU65_16275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU65_16280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISU65_16290	COG0762	integral membrane protein
ISU65_16295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISU65_16300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISU65_16305	COG2805	Type II/IV secretion system protein
ISU65_16315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU65_16330	COG0189	ligase activity
ISU65_16335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISU65_16340	COG2356	endonuclease I
ISU65_16355	COG1166	arginine decarboxylase activity
ISU65_16370	COG0501	Belongs to the peptidase M48B family
ISU65_16375	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISU65_16395	COG0191	fructose-bisphosphate aldolase activity
ISU65_16430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISU65_16440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISU65_16460	COG0006	proline dipeptidase activity
ISU65_16465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU65_16470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU65_16515	COG1272	protein, Hemolysin III
ISU65_16540	COG0745	RESPONSE REGULATOR receiver
ISU65_16545	COG2205	protein histidine kinase activity
ISU65_16550	COG4452	Inner membrane protein CreD
ISU65_16555	COG0716	FMN binding
ISU65_16560	COG4974	Belongs to the 'phage' integrase family
ISU65_16565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU65_16570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISU65_16590	COG0582	viral genome integration into host DNA
ISU65_16615	COG0582	viral genome integration into host DNA
ISU65_16625	COG0795	lipopolysaccharide-transporting ATPase activity
ISU65_16630	COG0795	lipopolysaccharide-transporting ATPase activity
ISU65_16640	COG2927	DNA polymerase III (CHI subunit)
ISU65_16645	COG0525	valine-tRNA ligase activity
ISU65_16655	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ISU65_16665	COG2731	YhcH YjgK YiaL family protein
ISU65_16675	COG0601	transmembrane transport
ISU65_16680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU65_16685	COG0444	Belongs to the ABC transporter superfamily
ISU65_16690	COG4608	Belongs to the ABC transporter superfamily
ISU65_16705	COG2188	Transcriptional regulator
ISU65_16710	COG3624	Phosphonate C-P lyase system protein PhnG
ISU65_16715	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISU65_16720	COG3626	phosphonate metabolism
ISU65_16725	COG3627	carbon phosphorus lyase activity
ISU65_16730	COG4107	phosphonate C-P lyase system protein PhnK
ISU65_16735	COG4778	phosphonate C-P lyase system protein PhnL
ISU65_16740	COG3454	Phosphonate metabolism
ISU65_16745	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ISU65_16750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISU65_16755	COG0702	epimerase
ISU65_16770	COG3842	ATPase activity
ISU65_16775	COG0395	ABC-type sugar transport system, permease component
ISU65_16780	COG1175	transmembrane transport
ISU65_16785	COG1653	transport
ISU65_16805	COG3153	acetyltransferase
ISU65_16810	COG3154	lipid carrier protein
ISU65_16815	COG0826	peptidase U32
ISU65_16820	COG0826	peptidase U32
ISU65_16830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU65_16840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISU65_16860	COG0513	Belongs to the DEAD box helicase family
ISU65_16905	COG0195	Participates in both transcription termination and antitermination
ISU65_16925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISU65_16935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISU65_16950	COG1534	Rna-binding protein
ISU65_16960	COG2027	D-alanyl-D-alanine carboxypeptidase
ISU65_16965	COG0745	RESPONSE REGULATOR receiver
ISU65_16970	COG0642	Histidine kinase
ISU65_16980	COG0697	spore germination
ISU65_16995	COG0142	geranyltranstransferase activity
ISU65_17005	COG3423	Transcriptional regulator
ISU65_17025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISU65_17030	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ISU65_17035	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISU65_17040	COG2105	PFAM AIG2 family protein
ISU65_17045	COG2911	Protein conserved in bacteria
ISU65_17050	COG0729	surface antigen
ISU65_17060	COG1253	flavin adenine dinucleotide binding
ISU65_17070	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISU65_17080	COG0737	Belongs to the 5'-nucleotidase family
ISU65_17090	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU65_17095	COG3061	Opacity-associated protein A
ISU65_17115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISU65_17125	COG0360	Binds together with S18 to 16S ribosomal RNA
ISU65_17130	COG1073	alpha beta
ISU65_17150	COG3650	response to hydrogen peroxide
ISU65_17155	COG1960	acyl-CoA dehydrogenase activity
ISU65_17160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU65_17165	COG0557	exoribonuclease II activity
ISU65_17180	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISU65_17185	COG0330	HflC and HflK could
ISU65_17190	COG0330	HflC and HflK could
ISU65_17195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISU65_17215	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU65_17220	COG0802	atpase or kinase
ISU65_17225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISU65_17225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISU65_17230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISU65_17245	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISU65_17260	COG3264	Mechanosensitive ion channel
ISU65_17260	COG1511	domain protein
ISU65_17275	COG1053	succinate dehydrogenase
ISU65_17280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISU65_17290	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ISU65_17335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISU65_17350	COG3383	formate dehydrogenase (NAD+) activity
ISU65_17355	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU65_17360	COG0493	'glutamate synthase
ISU65_17360	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU65_17365	COG1309	transcriptional regulator
ISU65_17425	COG1454	alcohol dehydrogenase
ISU65_17435	COG0629	single-stranded DNA binding
ISU65_17440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISU65_17445	COG2315	Protein conserved in bacteria
ISU65_17450	COG1448	Aminotransferase
ISU65_17475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU65_17480	COG0735	belongs to the Fur family
ISU65_17490	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISU65_17530	COG3121	Chaperone
ISU65_17590	COG1358	cellular component organization or biogenesis
ISU65_17615	COG3721	Heme iron utilization protein
ISU65_17620	COG0702	epimerase
ISU65_17630	COG4771	TonB-dependent receptor
ISU65_17635	COG3720	iron ion transport
ISU65_17640	COG4558	Periplasmic binding protein
ISU65_17645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_17655	COG0626	cystathionine gamma-synthase activity
ISU65_17660	COG0814	amino acid
ISU65_17665	COG0583	DNA-binding transcription factor activity
ISU65_17670	COG0425	Belongs to the sulfur carrier protein TusA family
ISU65_17675	COG2391	methyltransferase activity
ISU65_17785	COG1301	dicarboxylic acid transport
ISU65_17795	COG3162	membrane
ISU65_17855	COG0151	Belongs to the GarS family
ISU65_17875	COG1515	deoxyribonuclease V activity
ISU65_17910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISU65_17965	COG0250	Participates in transcription elongation, termination and antitermination
ISU65_18025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISU65_18055	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISU65_18060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISU65_18075	COG1739	Uncharacterized protein family UPF0029
ISU65_18100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISU65_18135	COG0805	protein transport
ISU65_18145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU65_18165	COG1322	Protein conserved in bacteria
ISU65_18170	COG0586	Pfam SNARE associated Golgi protein
ISU65_18175	COG1966	Carbon starvation protein
ISU65_18190	COG0412	Dienelactone hydrolase
ISU65_18200	COG0583	DNA-binding transcription factor activity
ISU65_18205	COG0697	spore germination
ISU65_18210	COG0679	Auxin Efflux Carrier
ISU65_18215	COG0584	glycerophosphoryl diester phosphodiesterase
ISU65_18275	COG0410	ABC transporter
ISU65_18285	COG4177	L-phenylalanine transmembrane transporter activity
ISU65_18295	COG0683	leucine binding
ISU65_18315	COG2177	Part of the ABC transporter FtsEX involved in
ISU65_18320	COG2884	Cell division ATP-binding protein ftsE
ISU65_18325	COG0552	protein localization to endoplasmic reticulum
ISU65_18325	COG0552	protein localization to endoplasmic reticulum
ISU65_18330	COG0742	ribosomal rna small subunit methyltransferase
ISU65_18335	COG3776	membrane
ISU65_18350	COG3714	YhhN family
ISU65_18365	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISU65_18375	COG0247	lactate metabolic process
ISU65_18385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU65_18390	COG0584	glycerophosphoryl diester phosphodiesterase
ISU65_18400	COG0561	phosphatase activity
ISU65_18405	COG2267	carboxylic ester hydrolase activity
ISU65_18410	COG1280	lysine exporter protein (LysE YggA)
ISU65_18415	COG1280	lysine exporter protein (LysE YggA)
ISU65_18420	COG0514	ATP-dependent DNA helicase (RecQ)
ISU65_18425	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ISU65_18430	COG2050	protein possibly involved in aromatic compounds catabolism
ISU65_18445	COG5564	TIM-barrel signal transduction protein
ISU65_18450	COG5441	Belongs to the UPF0261 family
ISU65_18460	COG0210	DNA helicase
ISU65_18465	COG1011	Hydrolase
ISU65_18470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ISU65_18475	COG3159	Protein conserved in bacteria
ISU65_18495	COG3072	Adenylate cyclase
ISU65_18510	COG1587	Uroporphyrinogen-III synthase
ISU65_18515	COG2959	enzyme of heme biosynthesis
ISU65_18520	COG3071	HemY protein
ISU65_18550	COG1113	amino acid transport
ISU65_18570	COG2244	polysaccharide biosynthetic process
ISU65_18575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISU65_18580	COG0456	acetyltransferase
ISU65_18585	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISU65_18590	COG1088	dTDP-glucose 4,6-dehydratase activity
ISU65_18595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISU65_18600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISU65_18605	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU65_18610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISU65_18615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISU65_18620	COG3118	belongs to the thioredoxin family
ISU65_18645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU65_18655	COG3328	transposase activity
ISU65_18665	COG3121	Chaperone
ISU65_18680	COG3121	Chaperone
ISU65_18715	COG0583	DNA-binding transcription factor activity
ISU65_18760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU65_18765	COG3978	acetolactate synthase activity
ISU65_18785	COG3085	chromosome segregation
ISU65_18795	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_18800	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_18805	COG1129	ABC transporter
ISU65_18810	COG1879	ABC-type sugar transport system periplasmic component
ISU65_18880	COG0678	peroxiredoxin activity
ISU65_18880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU65_18885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU65_18910	COG1629	transport
ISU65_18925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISU65_18950	COG0527	aspartate kinase activity
ISU65_18950	COG0460	homoserine dehydrogenase
ISU65_18965	COG4682	membrane
ISU65_18975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISU65_18980	COG1609	Transcriptional regulator
ISU65_18985	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU65_19000	COG1575	Belongs to the MenA family. Type 1 subfamily
ISU65_19110	COG3501	Rhs element vgr protein
ISU65_19155	COG3501	Rhs element vgr protein
ISU65_19165	COG3209	COG3209 Rhs family protein
ISU65_19185	COG0673	inositol 2-dehydrogenase activity
ISU65_19190	COG1917	Cupin 2, conserved barrel domain protein
ISU65_19190	COG2207	Transcriptional regulator
ISU65_19195	COG1869	D-ribose catabolic process
ISU65_19200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU65_19205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISU65_19210	COG0431	NADPH-dependent FMN reductase
ISU65_19215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISU65_19225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU65_19240	COG3077	Addiction module antitoxin, RelB DinJ family
ISU65_19245	COG2252	PERMEase
ISU65_19250	COG0025	NhaP-type Na H and K H
ISU65_19260	COG1560	Kdo2-lipid A biosynthetic process
ISU65_19270	COG1129	ABC transporter
ISU65_19275	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_19285	COG1069	ribulokinase activity
ISU65_19295	COG0625	glutathione transferase activity
ISU65_19315	COG1278	Cold shock
ISU65_19320	COG1278	Cold shock
ISU65_19325	COG3133	Outer membrane lipoprotein
ISU65_19330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU65_19340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU65_19370	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISU65_19375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU65_19385	COG4145	pantothenate transmembrane transporter activity
ISU65_19390	COG3924	membrane
ISU65_19400	COG0439	Biotin carboxylase
ISU65_19405	COG0511	ligase activity, forming carbon-carbon bonds
ISU65_19420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISU65_19425	COG0604	alcohol dehydrogenase
ISU65_19430	COG2199	diguanylate cyclase activity
ISU65_19430	COG2200	EAL domain
ISU65_19435	COG1077	Cell shape determining protein MreB Mrl
ISU65_19440	COG1792	Involved in formation and maintenance of cell shape
ISU65_19445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISU65_19450	COG0424	maF-like protein
ISU65_19455	COG1530	ribonuclease E activity
ISU65_19460	COG3164	Protein of unknown function
ISU65_19465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU65_19470	COG0312	modulator of DNA gyrase
ISU65_19520	COG0583	DNA-binding transcription factor activity
ISU65_19550	COG2732	(Barnase) inhibitor
ISU65_19560	COG0312	modulator of DNA gyrase
ISU65_19570	COG3783	Cytochrome b(562)
ISU65_19575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU65_19580	COG0366	Alpha amylase catalytic
ISU65_19585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU65_19585	COG1263	PTS System
ISU65_19590	COG1609	Transcriptional regulator
ISU65_19615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_19635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISU65_19640	COG1137	ATPase activity
ISU65_19645	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISU65_19650	COG3117	lipopolysaccharide transmembrane transporter activity
ISU65_19655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISU65_19660	COG0517	IMP dehydrogenase activity
ISU65_19660	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISU65_19665	COG0530	calcium, potassium:sodium antiporter activity
ISU65_19670	COG1127	ABC transporter
ISU65_19675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISU65_19680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU65_19685	COG2854	intermembrane phospholipid transfer
ISU65_19690	COG3113	response to antibiotic
ISU65_19695	COG5007	Belongs to the BolA IbaG family
ISU65_19705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU65_19715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU65_19720	COG3105	Protein conserved in bacteria
ISU65_19725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISU65_19745	COG0625	glutathione transferase activity
ISU65_19750	COG2969	positive regulation of protein catabolic process
ISU65_19760	COG0493	'glutamate synthase
ISU65_19765	COG0067	glutamate synthase
ISU65_19765	COG0069	glutamate synthase activity
ISU65_19765	COG0070	glutamate synthase
ISU65_19770	COG1242	4 iron, 4 sulfur cluster binding
ISU65_19775	COG5002	protein histidine kinase activity
ISU65_19775	COG0784	Response regulator, receiver
ISU65_19775	COG2198	Histidine kinase
ISU65_19780	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISU65_19790	COG2823	Periplasmic or secreted lipoprotein
ISU65_19810	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISU65_19820	COG1741	Belongs to the pirin family
ISU65_19825	COG0583	DNA-binding transcription factor activity
ISU65_19855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISU65_19860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU65_19865	COG1494	fructose-1,6-bisphosphatase
ISU65_19875	COG3152	Membrane
ISU65_19890	COG0583	DNA-binding transcription factor activity
ISU65_19895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISU65_19900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISU65_19905	COG0471	metal ion transport
ISU65_19915	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISU65_19940	COG3678	ATP-independent chaperone mediated protein folding
ISU65_19945	COG0745	RESPONSE REGULATOR receiver
ISU65_19950	COG2205	protein histidine kinase activity
ISU65_19955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU65_19955	COG2169	Transcriptional regulator
ISU65_19960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISU65_19965	COG1045	serine acetyltransferase
ISU65_19980	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU65_19985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU65_19995	COG4942	peptidase
ISU65_20010	COG0156	8-amino-7-oxononanoate synthase activity
ISU65_20020	COG0859	PFAM glycosyl transferase family 9
ISU65_20025	COG0859	PFAM glycosyl transferase family 9
ISU65_20030	COG1519	Transferase
ISU65_20065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISU65_20090	COG1561	YicC-like family, N-terminal region
ISU65_20095	COG2860	membrane
ISU65_20115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU65_20120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU65_20125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISU65_20135	COG0786	glutamate:sodium symporter activity
ISU65_20140	COG2233	PERMEase
ISU65_20145	COG2982	Protein involved in outer membrane biogenesis
ISU65_20150	COG0456	acetyltransferase
ISU65_20225	COG1175	transmembrane transport
ISU65_20230	COG3833	ABC-type maltose transport systems, permease component
ISU65_20245	COG0527	aspartate kinase activity
ISU65_20275	COG2224	Isocitrate lyase
ISU65_20280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISU65_20320	COG2186	Transcriptional regulator
ISU65_20325	COG0477	Major facilitator Superfamily
ISU65_20340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU65_20380	COG1522	sequence-specific DNA binding
ISU65_20385	COG0716	FMN binding
ISU65_20400	COG3312	ion transport
ISU65_20455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISU65_20460	COG0573	inorganic phosphate transmembrane transporter activity
ISU65_20465	COG0581	inorganic phosphate transmembrane transporter activity
ISU65_20475	COG0704	Plays a role in the regulation of phosphate uptake
ISU65_20485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_20490	COG0765	amino acid transport
ISU65_20495	COG0765	amino acid transport
ISU65_20500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU65_20510	COG2252	PERMEase
ISU65_20545	COG0706	membrane insertase activity
ISU65_20560	COG0230	Belongs to the bacterial ribosomal protein bL34 family