locus-tag	class	description
YPN_0001	COG0716	FMN binding
YPN_0002	COG1522	sequence-specific DNA binding
YPN_0008	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPN_0010	COG0477	Major facilitator Superfamily
YPN_0011	COG2186	Transcriptional regulator
YPN_0014	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
YPN_0015	COG2224	Isocitrate lyase
YPN_0017	COG1414	Transcriptional regulator
YPN_0022	COG0527	aspartate kinase activity
YPN_0025	COG3833	ABC-type maltose transport systems, permease component
YPN_0026	COG1175	transmembrane transport
YPN_0038	COG2801	Transposase and inactivated derivatives
YPN_0042	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
YPN_0045	COG1629	transport
YPN_0050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPN_0051	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YPN_0051	COG0678	peroxiredoxin activity
YPN_0059	COG1879	ABC-type sugar transport system periplasmic component
YPN_0060	COG1129	ABC transporter
YPN_0061	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_0062	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_0064	COG3085	chromosome segregation
YPN_0067	COG3978	acetolactate synthase activity
YPN_0068	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YPN_0076	COG0583	DNA-binding transcription factor activity
YPN_0083	COG3121	Chaperone
YPN_0086	COG3121	Chaperone
YPN_0088	COG3328	transposase activity
YPN_0090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YPN_0095	COG3118	belongs to the thioredoxin family
YPN_0096	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
YPN_0097	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YPN_0098	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YPN_0099	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
YPN_0100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
YPN_0101	COG1088	dTDP-glucose 4,6-dehydratase activity
YPN_0102	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
YPN_0103	COG0456	acetyltransferase
YPN_0104	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YPN_0105	COG2244	polysaccharide biosynthetic process
YPN_0109	COG1113	amino acid transport
YPN_0111	COG3071	HemY protein
YPN_0112	COG2959	enzyme of heme biosynthesis
YPN_0113	COG1587	Uroporphyrinogen-III synthase
YPN_0116	COG3072	Adenylate cyclase
YPN_0118	COG5567	small periplasmic lipoprotein
YPN_0120	COG3159	Protein conserved in bacteria
YPN_0121	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
YPN_0122	COG1011	Hydrolase
YPN_0123	COG0210	DNA helicase
YPN_0125	COG5441	Belongs to the UPF0261 family
YPN_0126	COG5564	TIM-barrel signal transduction protein
YPN_0127	COG0598	Magnesium transport protein CorA
YPN_0129	COG2050	protein possibly involved in aromatic compounds catabolism
YPN_0130	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
YPN_0131	COG0514	ATP-dependent DNA helicase (RecQ)
YPN_0132	COG1280	lysine exporter protein (LysE YggA)
YPN_0133	COG1280	lysine exporter protein (LysE YggA)
YPN_0134	COG2267	carboxylic ester hydrolase activity
YPN_0135	COG0561	phosphatase activity
YPN_0137	COG0584	glycerophosphoryl diester phosphodiesterase
YPN_0138	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YPN_0140	COG0247	lactate metabolic process
YPN_0142	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
YPN_0145	COG3714	YhhN family
YPN_0148	COG3776	membrane
YPN_0149	COG0742	ribosomal rna small subunit methyltransferase
YPN_0150	COG0552	protein localization to endoplasmic reticulum
YPN_0150	COG0552	protein localization to endoplasmic reticulum
YPN_0151	COG2884	Cell division ATP-binding protein ftsE
YPN_0152	COG2177	Part of the ABC transporter FtsEX involved in
YPN_0154	COG1943	Transposase
YPN_0156	COG0683	leucine binding
YPN_0157	COG0559	Belongs to the binding-protein-dependent transport system permease family
YPN_0158	COG4177	L-phenylalanine transmembrane transporter activity
YPN_0159	COG0411	ABC transporter
YPN_0160	COG0410	ABC transporter
YPN_0172	COG0584	glycerophosphoryl diester phosphodiesterase
YPN_0173	COG0679	Auxin Efflux Carrier
YPN_0175	COG0583	DNA-binding transcription factor activity
YPN_0177	COG0412	Dienelactone hydrolase
YPN_0178	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
YPN_0180	COG1966	Carbon starvation protein
YPN_0181	COG0586	Pfam SNARE associated Golgi protein
YPN_0182	COG1322	Protein conserved in bacteria
YPN_0186	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YPN_0188	COG0805	protein transport
YPN_0200	COG1739	Uncharacterized protein family UPF0029
YPN_0202	COG1739	Uncharacterized protein family UPF0029
YPN_0203	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YPN_0204	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
YPN_0205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
YPN_0213	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
YPN_0214	COG0250	Participates in transcription elongation, termination and antitermination
YPN_0221	COG1943	Transposase
YPN_0225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YPN_0227	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
YPN_0232	COG1515	deoxyribonuclease V activity
YPN_0233	COG3068	Protein conserved in bacteria
YPN_0236	COG0151	Belongs to the GarS family
YPN_0238	COG3328	transposase activity
YPN_0239	COG1763	Mo-molybdopterin cofactor biosynthetic process
YPN_0241	COG3084	Protein conserved in bacteria
YPN_0242	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
YPN_0243	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YPN_0244	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPN_0244	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPN_0245	COG1943	Transposase
YPN_0248	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YPN_0250	COG3852	Histidine kinase
YPN_0251	COG0174	glutamine synthetase
YPN_0253	COG1011	Hydrolase
YPN_0254	COG1295	ribonuclease BN
YPN_0258	COG1401	restriction endodeoxyribonuclease activity
YPN_0269	COG4269	membrane
YPN_0271	COG2207	Transcriptional regulator
YPN_0272	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPN_0273	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPN_0274	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPN_0275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPN_0275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YPN_0275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPN_0284	COG2390	Transcriptional regulator
YPN_0285	COG2390	Transcriptional regulator
YPN_0287	COG0859	PFAM glycosyl transferase family 9
YPN_0290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPN_0291	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPN_0295	COG3706	GGDEF domain
YPN_0299	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
YPN_0300	COG0456	acetyltransferase
YPN_0302	COG2823	Periplasmic or secreted lipoprotein
YPN_0304	COG4667	esterase of the alpha-beta hydrolase superfamily
YPN_0305	COG0084	hydrolase, TatD family'
YPN_0306	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YPN_0307	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YPN_0312	COG3726	membrane protein affecting hemolysin expression
YPN_0313	COG0560	Phosphoserine phosphatase
YPN_0317	COG0488	(ABC) transporter
YPN_0318	COG0488	(ABC) transporter
YPN_0319	COG2885	chlorophyll binding
YPN_0320	COG2199	diguanylate cyclase activity
YPN_0323	COG0741	lytic transglycosylase activity
YPN_0324	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
YPN_0327	COG3708	Transcriptional regulator
YPN_0327	COG2207	Transcriptional regulator
YPN_0328	COG3045	CreA protein
YPN_0329	COG0745	RESPONSE REGULATOR receiver
YPN_0337	COG0521	Mo-molybdopterin cofactor biosynthetic process
YPN_0340	COG1584	GPR1 FUN34 yaaH family protein
YPN_0344	COG0583	DNA-binding transcription factor activity
YPN_0346	COG0196	riboflavin kinase activity
YPN_0349	COG1047	Peptidyl-prolyl cis-trans
YPN_0352	COG1943	Transposase
YPN_0354	COG0505	Belongs to the CarA family
YPN_0355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
YPN_0356	COG1280	lysine exporter protein (LysE YggA)
YPN_0357	COG2966	Psort location CytoplasmicMembrane, score
YPN_0359	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
YPN_0360	COG1943	Transposase
YPN_0367	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
YPN_0368	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YPN_0370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
YPN_0371	COG0564	pseudouridine synthase activity
YPN_0382	COG3501	Rhs element vgr protein
YPN_0389	COG2885	chlorophyll binding
YPN_0389	COG3047	cAMP biosynthetic process
YPN_0393	COG0417	DNA replication proofreading
YPN_0394	COG0586	Pfam SNARE associated Golgi protein
YPN_0396	COG1178	ABC-type Fe3 transport system permease component
YPN_0397	COG4143	(ABC) transporter
YPN_0399	COG2814	Major facilitator Superfamily
YPN_0402	COG0473	3-isopropylmalate dehydrogenase activity
YPN_0404	COG1943	Transposase
YPN_0406	COG1022	Amp-dependent synthetase and ligase
YPN_0407	COG0028	Belongs to the TPP enzyme family
YPN_0409	COG1943	Transposase
YPN_0410	COG1609	Transcriptional regulator
YPN_0414	COG3116	cell division
YPN_0415	COG0768	penicillin binding
YPN_0416	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YPN_0417	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YPN_0420	COG0772	Belongs to the SEDS family
YPN_0424	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
YPN_0425	COG0849	cell division
YPN_0426	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
YPN_0431	COG0494	nUDIX hydrolase
YPN_0435	COG0435	Glutathione S-transferase
YPN_0436	COG2259	Doxx family
YPN_0438	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
YPN_0439	COG4575	ribosome binding
YPN_0443	COG0586	Pfam SNARE associated Golgi protein
YPN_0446	COG2271	Major facilitator Superfamily
YPN_0449	COG0246	Mannitol dehydrogenase
YPN_0450	COG2721	sulfolactate sulfo-lyase activity
YPN_0452	COG1943	Transposase
YPN_0454	COG0673	inositol 2-dehydrogenase activity
YPN_0455	COG1451	nucleotide metabolic process
YPN_0458	COG0446	pyridine nucleotide-disulphide oxidoreductase
YPN_0458	COG1902	pentaerythritol trinitrate reductase activity
YPN_0459	COG3247	response to pH
YPN_0462	COG4245	von Willebrand factor, type A
YPN_0465	COG4245	von Willebrand factor, type A
YPN_0466	COG2831	hemolysin activation secretion protein
YPN_0467	COG3210	domain, Protein
YPN_0468	COG3210	domain, Protein
YPN_0472	COG3842	ATPase activity
YPN_0473	COG3459	Glycosyltransferase 36 associated
YPN_0474	COG1609	Transcriptional regulator
YPN_0475	COG1653	transport
YPN_0477	COG0395	ABC-type sugar transport system, permease component
YPN_0481	COG1289	transmembrane transporter activity
YPN_0490	COG0251	oxidation-reduction process
YPN_0503	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YPN_0504	COG0358	DNA primase activity
YPN_0508	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
YPN_0511	COG4991	sh3 domain protein
YPN_0512	COG3025	triphosphatase activity
YPN_0515	COG0531	amino acid
YPN_0518	COG3384	dioxygenase
YPN_0519	COG0754	glutathionylspermidine amidase activity
YPN_0521	COG1538	Outer membrane efflux protein
YPN_0522	COG0494	nUDIX hydrolase
YPN_0523	COG3151	Protein conserved in bacteria
YPN_0524	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YPN_0525	COG3150	esterase
YPN_0526	COG0187	DNA topoisomerase II activity
YPN_0527	COG0583	DNA-binding transcription factor activity
YPN_0528	COG2249	NAD(P)H dehydrogenase (quinone) activity
YPN_0529	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YPN_0530	COG0204	Acyl-transferase
YPN_0531	COG2132	Multicopper oxidase
YPN_0534	COG0656	L-ascorbic acid biosynthetic process
YPN_0535	COG1979	alcohol dehydrogenase
YPN_0536	COG2207	Transcriptional regulator
YPN_0537	COG0586	Pfam SNARE associated Golgi protein
YPN_0538	COG0626	cystathionine gamma-synthase activity
YPN_0539	COG0811	peptide transport
YPN_0540	COG0848	biopolymer transport protein
YPN_0550	COG4964	Belongs to the GSP D family
YPN_0551	COG4964	Belongs to the GSP D family
YPN_0558	COG4592	Periplasmic binding protein
YPN_0564	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPN_0565	COG1684	flagellar biosynthetic protein fliR
YPN_0566	COG1987	bacterial-type flagellum assembly
YPN_0570	COG2204	response regulator
YPN_0579	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
YPN_0580	COG1815	bacterial-type flagellum-dependent cell motility
YPN_0581	COG1558	bacterial-type flagellum-dependent cell motility
YPN_0582	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
YPN_0583	COG1749	Flagellar hook protein flgE
YPN_0584	COG4787	bacterial-type flagellum-dependent cell motility
YPN_0585	COG4786	Flagellar basal body rod
YPN_0586	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
YPN_0587	COG1706	bacterial-type flagellum-dependent cell motility
YPN_0589	COG1256	bacterial-type flagellum assembly
YPN_0593	COG3710	Transcriptional regulator
YPN_0596	COG2801	Transposase and inactivated derivatives
YPN_0599	COG0513	Belongs to the DEAD box helicase family
YPN_0603	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YPN_0605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPN_0611	COG3153	acetyltransferase
YPN_0615	COG1653	transport
YPN_0617	COG0395	ABC-type sugar transport system, permease component
YPN_0618	COG3842	ATPase activity
YPN_0621	COG0702	epimerase
YPN_0622	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YPN_0623	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
YPN_0624	COG3454	Phosphonate metabolism
YPN_0625	COG4778	phosphonate C-P lyase system protein PhnL
YPN_0626	COG4107	phosphonate C-P lyase system protein PhnK
YPN_0627	COG3627	carbon phosphorus lyase activity
YPN_0628	COG3626	phosphonate metabolism
YPN_0629	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
YPN_0630	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
YPN_0631	COG3624	Phosphonate C-P lyase system protein PhnG
YPN_0632	COG2188	Transcriptional regulator
YPN_0635	COG4608	Belongs to the ABC transporter superfamily
YPN_0636	COG0444	Belongs to the ABC transporter superfamily
YPN_0637	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPN_0638	COG0601	transmembrane transport
YPN_0641	COG2731	YhcH YjgK YiaL family protein
YPN_0642	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YPN_0643	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
YPN_0645	COG0525	valine-tRNA ligase activity
YPN_0646	COG2927	DNA polymerase III (CHI subunit)
YPN_0648	COG0795	lipopolysaccharide-transporting ATPase activity
YPN_0649	COG0795	lipopolysaccharide-transporting ATPase activity
YPN_0651	COG0582	viral genome integration into host DNA
YPN_0659	COG0237	dephospho-CoA kinase activity
YPN_0661	COG1459	type II secretion system
YPN_0662	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YPN_0663	COG4969	Belongs to the N-Me-Phe pilin family
YPN_0665	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPN_0666	COG3725	Membrane protein required for beta-lactamase induction
YPN_0667	COG1113	amino acid transport
YPN_0668	COG2186	Transcriptional regulator
YPN_0669	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
YPN_0670	COG0508	dehydrogenase complex catalyzes the overall conversion of
YPN_0671	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPN_0672	COG1943	Transposase
YPN_0673	COG1049	propionate catabolic process, 2-methylcitrate cycle
YPN_0675	COG0697	spore germination
YPN_0679	COG2132	Multicopper oxidase
YPN_0680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
YPN_0681	COG0288	reversible hydration of carbon dioxide
YPN_0682	COG1131	(ABC) transporter
YPN_0683	COG0842	Transport permease protein
YPN_0685	COG0726	polysaccharide deacetylase
YPN_0689	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YPN_0690	COG0617	tRNA 3'-terminal CCA addition
YPN_0691	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YPN_0693	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
YPN_0695	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
YPN_0696	COG1643	Atp-dependent helicase
YPN_0697	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YPN_0698	COG1120	ATPase activity
YPN_0699	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YPN_0700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPN_0705	COG2860	membrane
YPN_0707	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YPN_0709	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPN_0710	COG4999	Histidine kinase
YPN_0710	COG3850	Histidine kinase
YPN_0710	COG3437	response regulator, receiver
YPN_0710	COG2205	protein histidine kinase activity
YPN_0712	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YPN_0713	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YPN_0714	COG3956	TIGRFAM MazG family protein
YPN_0718	COG0602	queuosine metabolic process
YPN_0719	COG0720	synthase
YPN_0729	COG0529	Catalyzes the synthesis of activated sulfate
YPN_0732	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
YPN_0737	COG4942	peptidase
YPN_0737	COG1388	LysM domain
YPN_0738	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YPN_0739	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
YPN_0741	COG0698	ribose 5-phosphate isomerase
YPN_0742	COG1063	alcohol dehydrogenase
YPN_0743	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_0744	COG2376	Dihydroxyacetone kinase
YPN_0747	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YPN_0750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPN_0751	COG1858	cytochrome C peroxidase
YPN_0753	COG4771	TonB-dependent receptor
YPN_0756	COG0024	Methionine aminopeptidase
YPN_0758	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
YPN_0758	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
YPN_0759	COG1070	Carbohydrate kinase
YPN_0760	COG3623	hexulose-6-phosphate isomerase
YPN_0761	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_0762	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_0763	COG1129	ABC transporter
YPN_0764	COG1943	Transposase
YPN_0766	COG1349	DNA-binding transcription factor activity
YPN_0767	COG0235	Class ii aldolase
YPN_0768	COG0243	molybdopterin cofactor binding
YPN_0769	COG0437	4 iron, 4 sulfur cluster binding
YPN_0770	COG3302	dmso reductase anchor subunit
YPN_0771	COG3381	protein complex oligomerization
YPN_0772	COG3038	cytochrome b561
YPN_0773	COG3783	Cytochrome b(562)
YPN_0777	COG1129	ABC transporter
YPN_0778	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_0779	COG3959	Transketolase, thiamine diphosphate binding domain
YPN_0780	COG3958	Transketolase
YPN_0781	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YPN_0789	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YPN_0790	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
YPN_0791	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPN_0792	COG1238	metal cluster binding
YPN_0793	COG2918	glutathione biosynthetic process
YPN_0799	COG4536	flavin adenine dinucleotide binding
YPN_0800	COG4137	Cytochrome C assembly protein
YPN_0801	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YPN_0807	COG1943	Transposase
YPN_0808	COG3137	Salt-induced outer membrane protein
YPN_0809	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPN_0810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPN_0811	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPN_0812	COG3279	Response regulator of the LytR AlgR family
YPN_0813	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YPN_0814	COG0287	Prephenate dehydrogenase
YPN_0814	COG1605	Chorismate mutase
YPN_0815	COG0077	Prephenate dehydratase
YPN_0815	COG1605	Chorismate mutase
YPN_0816	COG1943	Transposase
YPN_0817	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
YPN_0818	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPN_0819	COG0564	pseudouridine synthase activity
YPN_0821	COG0542	response to heat
YPN_0822	COG5544	Lipoprotein
YPN_0823	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YPN_0824	COG1042	CoA-binding domain protein
YPN_0824	COG0045	succinate-CoA ligase (ADP-forming) activity
YPN_0824	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPN_0826	COG3118	belongs to the thioredoxin family
YPN_0827	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPN_0828	COG2814	Major facilitator Superfamily
YPN_0829	COG1566	PFAM secretion protein HlyD family protein
YPN_0830	COG1846	Transcriptional regulator
YPN_0832	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
YPN_0833	COG2814	Major facilitator Superfamily
YPN_0843	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YPN_0848	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
YPN_0850	COG1960	acyl-CoA dehydrogenase activity
YPN_0852	COG0121	glutamine amidotransferase
YPN_0853	COG3034	peptidoglycan biosynthetic process
YPN_0855	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YPN_0856	COG1805	sodium ion transport
YPN_0857	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YPN_0861	COG1477	protein flavinylation
YPN_0865	COG2195	Cleaves the N-terminal amino acid of tripeptides
YPN_0866	COG0583	DNA-binding transcription factor activity
YPN_0876	COG2226	methyltransferase
YPN_0881	COG1940	carbohydrate kinase activity
YPN_0882	COG0419	ATPase involved in DNA repair
YPN_0883	COG0420	3'-5' exonuclease activity
YPN_0884	COG0745	RESPONSE REGULATOR receiver
YPN_0885	COG5002	protein histidine kinase activity
YPN_0887	COG1114	Component of the transport system for branched-chain amino acids
YPN_0889	COG0366	Alpha amylase catalytic
YPN_0893	COG0450	alkyl hydroperoxide reductase
YPN_0894	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
YPN_0895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
YPN_0897	COG1862	Preprotein translocase
YPN_0898	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YPN_0899	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YPN_0901	COG1943	Transposase
YPN_0905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YPN_0905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YPN_0908	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
YPN_0909	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
YPN_0912	COG0142	geranyltranstransferase activity
YPN_0916	COG0693	protein deglycase activity
YPN_0917	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
YPN_0922	COG2814	Major facilitator Superfamily
YPN_0924	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
YPN_0925	COG1845	cytochrome c oxidase, subunit III
YPN_0926	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YPN_0927	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YPN_0929	COG2223	nitrite transmembrane transporter activity
YPN_0930	COG3056	Lipoprotein
YPN_0931	COG0271	Belongs to the BolA IbaG family
YPN_0935	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YPN_0936	COG0776	regulation of translation
YPN_0937	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YPN_0938	COG1555	photosystem II stabilization
YPN_0939	COG0824	Thioesterase
YPN_0941	COG4533	DNA binding
YPN_0944	COG1522	sequence-specific DNA binding
YPN_0945	COG1132	(ABC) transporter
YPN_0946	COG1132	(ABC) transporter
YPN_0947	COG0347	Belongs to the P(II) protein family
YPN_0948	COG0004	ammonium transporteR
YPN_0949	COG1946	Acyl-CoA thioesterase
YPN_0950	COG3126	Type III secretion system lipoprotein chaperone (YscW)
YPN_0951	COG3695	enzyme binding
YPN_0955	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YPN_0957	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPN_0958	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPN_0959	COG1309	transcriptional regulator
YPN_0960	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
YPN_0961	COG3264	Mechanosensitive ion channel
YPN_0961	COG1196	nuclear chromosome segregation
YPN_0964	COG2832	Protein of unknown function (DUF454)
YPN_0966	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
YPN_0973	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPN_0973	COG0543	2 iron, 2 sulfur cluster binding
YPN_0978	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPN_0985	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
YPN_0986	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
YPN_0987	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPN_0991	COG3328	transposase activity
YPN_0992	COG3328	transposase activity
YPN_0993	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YPN_0994	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPN_0995	COG4651	solute:proton antiporter activity
YPN_0995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YPN_0996	COG2223	nitrite transmembrane transporter activity
YPN_0997	COG0737	Belongs to the 5'-nucleotidase family
YPN_0998	COG0737	Belongs to the 5'-nucleotidase family
YPN_0999	COG0737	Belongs to the 5'-nucleotidase family
YPN_1001	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YPN_1002	COG3735	TraB family
YPN_1003	COG2217	Heavy metal translocating P-type atpase
YPN_1004	COG0789	Transcriptional regulator
YPN_1005	COG1585	Membrane protein implicated in regulation of membrane protease activity
YPN_1006	COG0330	HflC and HflK could
YPN_1007	COG3118	belongs to the thioredoxin family
YPN_1008	COG0300	oxidoreductase activity
YPN_1009	COG2755	lipolytic protein G-D-S-L family
YPN_1010	COG4181	ATPase activity
YPN_1011	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
YPN_1012	COG1943	Transposase
YPN_1013	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
YPN_1014	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
YPN_1016	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YPN_1018	COG1943	Transposase
YPN_1019	COG2501	S4 domain
YPN_1023	COG0582	viral genome integration into host DNA
YPN_1024	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
YPN_1025	COG4589	Belongs to the CDS family
YPN_1027	COG2267	carboxylic ester hydrolase activity
YPN_1028	COG2453	phosphatase
YPN_1028	COG0671	phosphoesterase, PA-phosphatase related
YPN_1034	COG0667	Aldo Keto reductase
YPN_1035	COG0656	L-ascorbic acid biosynthetic process
YPN_1042	COG3328	transposase activity
YPN_1043	COG2850	peptidyl-arginine hydroxylation
YPN_1054	COG3423	Transcriptional regulator
YPN_1055	COG4953	penicillin-binding protein 1C
YPN_1056	COG1943	Transposase
YPN_1057	COG2373	Large extracellular alpha-helical protein
YPN_1062	COG3962	Belongs to the TPP enzyme family
YPN_1063	COG0673	inositol 2-dehydrogenase activity
YPN_1064	COG0673	inositol 2-dehydrogenase activity
YPN_1065	COG1879	ABC-type sugar transport system periplasmic component
YPN_1066	COG1129	ABC transporter
YPN_1067	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_1068	COG0673	inositol 2-dehydrogenase activity
YPN_1069	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPN_1071	COG3718	enzyme involved in inositol metabolism
YPN_1073	COG5265	(ABC) transporter
YPN_1078	COG2197	response regulator
YPN_1079	COG1278	Cold shock
YPN_1081	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPN_1082	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YPN_1086	COG1686	Belongs to the peptidase S11 family
YPN_1087	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YPN_1088	COG0772	Belongs to the SEDS family
YPN_1089	COG0768	penicillin binding
YPN_1091	COG0799	negative regulation of ribosome biogenesis
YPN_1093	COG1466	dna polymerase III delta subunit
YPN_1096	COG2888	peptidyl-tyrosine sulfation
YPN_1097	COG1126	abc transporter atp-binding protein
YPN_1098	COG0765	amino acid transport
YPN_1099	COG0765	amino acid transport
YPN_1101	COG0815	Transfers the fatty acyl group on membrane lipoproteins
YPN_1102	COG4535	Mg2 and Co2 transporter CorC
YPN_1105	COG1702	phosphate starvation-inducible protein PhoH
YPN_1107	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPN_1109	COG0367	asparagine synthase
YPN_1110	COG0647	UMP catabolic process
YPN_1111	COG1846	Transcriptional regulator
YPN_1111	COG1940	carbohydrate kinase activity
YPN_1112	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
YPN_1114	COG1263	PTS System
YPN_1114	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPN_1114	COG2190	(PTS) system
YPN_1115	COG1943	Transposase
YPN_1120	COG0735	belongs to the Fur family
YPN_1123	COG0596	Alpha beta hydrolase
YPN_1124	COG0582	viral genome integration into host DNA
YPN_1125	COG2963	transposase activity
YPN_1126	COG0582	viral genome integration into host DNA
YPN_1131	COG2113	Glycine betaine
YPN_1132	COG4176	ABC-type proline glycine betaine transport system permease component
YPN_1133	COG4175	Glycine betaine
YPN_1134	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YPN_1142	COG1278	Cold shock
YPN_1143	COG0747	negative chemotaxis
YPN_1145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPN_1146	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YPN_1147	COG1124	(ABC) transporter
YPN_1154	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
YPN_1157	COG4413	Urea transporter
YPN_1158	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
YPN_1160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YPN_1161	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPN_1162	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPN_1164	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YPN_1165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YPN_1166	COG1447	Phosphotransferase system cellobiose-specific component IIA
YPN_1167	COG2169	Transcriptional regulator
YPN_1167	COG1917	Cupin 2, conserved barrel domain protein
YPN_1170	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
YPN_1171	COG0033	Phosphoglucomutase
YPN_1175	COG0745	RESPONSE REGULATOR receiver
YPN_1176	COG2205	protein histidine kinase activity
YPN_1182	COG3272	Protein of unknown function (DUF1722)
YPN_1184	COG5212	phosphodiesterase
YPN_1185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
YPN_1186	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
YPN_1187	COG1984	allophanate hydrolase subunit 2
YPN_1196	COG0513	Belongs to the DEAD box helicase family
YPN_1198	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
YPN_1200	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
YPN_1201	COG3026	antisigma factor binding
YPN_1202	COG3086	response to oxidative stress
YPN_1205	COG0681	Belongs to the peptidase S26 family
YPN_1209	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
YPN_1211	COG1943	Transposase
YPN_1212	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPN_1213	COG1737	Transcriptional regulator
YPN_1215	COG0560	Phosphoserine phosphatase
YPN_1216	COG0590	tRNA wobble adenosine to inosine editing
YPN_1222	COG2205	protein histidine kinase activity
YPN_1223	COG3170	Tfp pilus assembly protein FimV
YPN_1224	COG2204	response regulator
YPN_1225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPN_1225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YPN_1226	COG0347	Belongs to the P(II) protein family
YPN_1227	COG2188	Transcriptional regulator
YPN_1230	COG2188	Transcriptional regulator
YPN_1231	COG1017	nitric oxide dioxygenase activity
YPN_1231	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPN_1234	COG2814	Major facilitator Superfamily
YPN_1235	COG3711	transcriptional antiterminator
YPN_1236	COG3683	transport system, periplasmic component
YPN_1237	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
YPN_1238	COG0483	inositol monophosphate 1-phosphatase activity
YPN_1241	COG1104	cysteine desulfurase activity
YPN_1242	COG0822	iron-sulfur transferase activity
YPN_1245	COG0443	Heat shock 70 kDa protein
YPN_1246	COG0633	Ferredoxin
YPN_1247	COG2975	iron-sulfur cluster assembly
YPN_1251	COG3468	outer membrane autotransporter barrel domain protein
YPN_1252	COG3468	outer membrane autotransporter barrel domain protein
YPN_1261	COG2976	Protein conserved in bacteria
YPN_1262	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPN_1265	COG1645	bacterial-type flagellum-dependent swarming motility
YPN_1267	COG0516	GMP reductase activity
YPN_1267	COG0517	IMP dehydrogenase activity
YPN_1269	COG1943	Transposase
YPN_1275	COG3328	transposase activity
YPN_1278	COG0351	phosphomethylpyrimidine kinase
YPN_1284	COG3422	double-strand break repair
YPN_1285	COG0745	RESPONSE REGULATOR receiver
YPN_1286	COG2205	protein histidine kinase activity
YPN_1287	COG2205	protein histidine kinase activity
YPN_1292	COG3842	ATPase activity
YPN_1294	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YPN_1296	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPN_1297	COG1177	transmembrane transport
YPN_1298	COG0443	Heat shock 70 kDa protein
YPN_1299	COG2239	Acts as a magnesium transporter
YPN_1300	COG0248	Ppx GppA phosphatase
YPN_1301	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
YPN_1303	COG0573	inorganic phosphate transmembrane transporter activity
YPN_1304	COG0581	inorganic phosphate transmembrane transporter activity
YPN_1308	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPN_1309	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
YPN_1312	COG1943	Transposase
YPN_1314	COG1393	Belongs to the ArsC family
YPN_1315	COG4783	chaperone-mediated protein folding
YPN_1316	COG0628	permease
YPN_1321	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YPN_1322	COG2716	regulation of RNA biosynthetic process
YPN_1324	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
YPN_1325	COG1943	Transposase
YPN_1327	COG2321	neutral zinc metallopeptidase
YPN_1331	COG1876	peptidase activity
YPN_1333	COG1393	Belongs to the ArsC family
YPN_1335	COG1840	ABC-type Fe3 transport system, periplasmic component
YPN_1336	COG1175	transmembrane transport
YPN_1337	COG3842	ATPase activity
YPN_1338	COG3119	arylsulfatase activity
YPN_1339	COG0641	radical SAM
YPN_1340	COG1988	membrane-bound metal-dependent
YPN_1342	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPN_1344	COG2197	response regulator
YPN_1345	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPN_1345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPN_1346	COG3062	negative regulation of establishment of protein localization
YPN_1348	COG3043	anaerobic respiration
YPN_1349	COG3005	denitrification pathway
YPN_1358	COG3111	PFAM Bacterial OB fold (BOF) protein
YPN_1360	COG2837	iron assimilation
YPN_1361	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YPN_1363	COG4886	Leucine-rich repeat (LRR) protein
YPN_1365	COG2731	YhcH YjgK YiaL family protein
YPN_1366	COG1737	Transcriptional regulator
YPN_1368	COG4150	thiosulfate binding
YPN_1369	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
YPN_1370	COG4208	sulfate ABC transporter
YPN_1371	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
YPN_1374	COG0745	RESPONSE REGULATOR receiver
YPN_1375	COG5002	protein histidine kinase activity
YPN_1375	COG3850	Histidine kinase
YPN_1377	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
YPN_1379	COG0006	proline dipeptidase activity
YPN_1380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YPN_1383	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPN_1384	COG0745	RESPONSE REGULATOR receiver
YPN_1385	COG2205	protein histidine kinase activity
YPN_1387	COG2190	(PTS) system
YPN_1389	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPN_1390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YPN_1391	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
YPN_1394	COG3530	Putative quorum-sensing-regulated virulence factor
YPN_1397	COG1943	Transposase
YPN_1399	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YPN_1402	COG0667	Aldo Keto reductase
YPN_1407	COG0436	Aminotransferase
YPN_1408	COG3038	cytochrome b561
YPN_1414	COG3381	protein complex oligomerization
YPN_1415	COG3302	dmso reductase anchor subunit
YPN_1416	COG0437	4 iron, 4 sulfur cluster binding
YPN_1417	COG0243	molybdopterin cofactor binding
YPN_1424	COG2951	lytic endotransglycosylase activity
YPN_1436	COG3121	Chaperone
YPN_1437	COG3188	usher protein
YPN_1438	COG3328	transposase activity
YPN_1439	COG3328	transposase activity
YPN_1440	COG3188	usher protein
YPN_1450	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
YPN_1454	COG0402	S-adenosylhomocysteine deaminase activity
YPN_1457	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YPN_1458	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YPN_1459	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPN_1468	COG3328	transposase activity
YPN_1472	COG0500	methyltransferase
YPN_1480	COG5002	protein histidine kinase activity
YPN_1491	COG0012	GTP binding
YPN_1494	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YPN_1500	COG2890	protein-(glutamine-N5) methyltransferase activity
YPN_1501	COG3094	Invasion gene expression up-regulator, SirB
YPN_1502	COG2912	Transglutaminase-like superfamily
YPN_1504	COG0659	secondary active sulfate transmembrane transporter activity
YPN_1507	COG3833	ABC-type maltose transport systems, permease component
YPN_1508	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPN_1511	COG3842	ATPase activity
YPN_1512	COG0584	glycerophosphoryl diester phosphodiesterase
YPN_1513	COG1940	carbohydrate kinase activity
YPN_1515	COG3381	protein complex oligomerization
YPN_1518	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPN_1520	COG0728	peptidoglycan biosynthetic process
YPN_1524	COG3102	Protein conserved in bacteria
YPN_1528	COG3788	relative of glutathione S-transferase, MAPEG superfamily
YPN_1529	COG1801	Protein of unknown function DUF72
YPN_1531	COG0494	nUDIX hydrolase
YPN_1536	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPN_1538	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
YPN_1539	COG0739	heme binding
YPN_1540	COG1560	Kdo2-lipid A biosynthetic process
YPN_1541	COG0469	pyruvate kinase activity
YPN_1542	COG1737	Transcriptional regulator
YPN_1543	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YPN_1544	COG0800	Aldolase
YPN_1547	COG0251	oxidation-reduction process
YPN_1548	COG1199	ATP-dependent helicase activity
YPN_1550	COG3065	identical protein binding
YPN_1551	COG0318	PFAM AMP-dependent synthetase and ligase
YPN_1552	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
YPN_1553	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
YPN_1554	COG2894	cell division
YPN_1557	COG2951	lytic endotransglycosylase activity
YPN_1558	COG0179	Fumarylacetoacetate (FAA) hydrolase
YPN_1560	COG0582	viral genome integration into host DNA
YPN_1576	COG3328	transposase activity
YPN_1592	COG1943	Transposase
YPN_1605	COG3328	transposase activity
YPN_1607	COG1104	cysteine desulfurase activity
YPN_1613	COG2719	SpoVR family
YPN_1615	COG2814	Major facilitator Superfamily
YPN_1617	COG0583	DNA-binding transcription factor activity
YPN_1620	COG2766	serine protein kinase
YPN_1621	COG3713	MltA-interacting MipA family protein
YPN_1625	COG3139	Protein of unknown function (DUF1315)
YPN_1626	COG1335	isochorismatase
YPN_1627	COG0252	asparaginase activity
YPN_1628	COG0616	signal peptide processing
YPN_1629	COG0778	Nitroreductase
YPN_1630	COG0709	Synthesizes selenophosphate from selenide and ATP
YPN_1631	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YPN_1633	COG0494	nUDIX hydrolase
YPN_1634	COG0708	Exodeoxyribonuclease III
YPN_1635	COG0583	DNA-binding transcription factor activity
YPN_1637	COG3328	transposase activity
YPN_1638	COG0788	formyltetrahydrofolate deformylase activity
YPN_1640	COG0745	RESPONSE REGULATOR receiver
YPN_1643	COG1435	thymidine kinase activity
YPN_1646	COG1454	alcohol dehydrogenase
YPN_1646	COG1012	belongs to the aldehyde dehydrogenase family
YPN_1647	COG2095	MarC family integral membrane protein
YPN_1649	COG0601	transmembrane transport
YPN_1650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPN_1651	COG0444	Belongs to the ABC transporter superfamily
YPN_1652	COG4608	Belongs to the ABC transporter superfamily
YPN_1660	COG2350	Protein conserved in bacteria
YPN_1661	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
YPN_1662	COG3328	transposase activity
YPN_1663	COG1607	acyl-coa hydrolase
YPN_1669	COG3047	cAMP biosynthetic process
YPN_1674	COG0134	indole-3-glycerol-phosphate synthase activity
YPN_1674	COG0135	phosphoribosylanthranilate isomerase activity
YPN_1676	COG0512	Glutamine amidotransferase of anthranilate synthase
YPN_1679	COG0009	L-threonylcarbamoyladenylate synthase
YPN_1680	COG1187	pseudouridine synthase activity
YPN_1682	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_1683	COG0616	signal peptide processing
YPN_1686	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YPN_1687	COG0583	DNA-binding transcription factor activity
YPN_1689	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
YPN_1690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YPN_1692	COG0671	phosphoesterase, PA-phosphatase related
YPN_1693	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
YPN_1694	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
YPN_1697	COG0023	Translation Initiation Factor
YPN_1701	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YPN_1702	COG2879	small protein
YPN_1703	COG1966	Carbon starvation protein
YPN_1705	COG2271	Major facilitator Superfamily
YPN_1706	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPN_1707	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YPN_1709	COG4659	FMN binding
YPN_1710	COG4658	electron transport chain
YPN_1711	COG2207	Transcriptional regulator
YPN_1711	COG3708	Transcriptional regulator
YPN_1718	COG2274	protein secretion by the type I secretion system
YPN_1720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPN_1721	COG2274	protein secretion by the type I secretion system
YPN_1724	COG1879	ABC-type sugar transport system periplasmic component
YPN_1726	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_1729	COG0673	inositol 2-dehydrogenase activity
YPN_1730	COG0385	Bile acid
YPN_1733	COG3328	transposase activity
YPN_1734	COG5339	Protein conserved in bacteria
YPN_1736	COG0114	fumarate hydratase activity
YPN_1738	COG2814	Major facilitator Superfamily
YPN_1739	COG0583	DNA-binding transcription factor activity
YPN_1740	COG1940	carbohydrate kinase activity
YPN_1741	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YPN_1742	COG0038	chloride channel
YPN_1743	COG1609	Transcriptional regulator
YPN_1745	COG1879	ABC-type sugar transport system periplasmic component
YPN_1746	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YPN_1747	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPN_1749	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YPN_1755	COG0028	Belongs to the TPP enzyme family
YPN_1756	COG0440	acetolactate synthase activity
YPN_1757	COG1011	Hydrolase
YPN_1760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YPN_1761	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YPN_1762	COG0589	response to stress
YPN_1763	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
YPN_1764	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
YPN_1766	COG0531	amino acid
YPN_1768	COG0745	RESPONSE REGULATOR receiver
YPN_1769	COG2205	protein histidine kinase activity
YPN_1771	COG3328	transposase activity
YPN_1772	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
YPN_1777	COG3038	cytochrome b561
YPN_1779	COG3591	Belongs to the peptidase S1B family
YPN_1781	COG1643	Atp-dependent helicase
YPN_1783	COG2390	Transcriptional regulator
YPN_1784	COG0246	Mannitol dehydrogenase
YPN_1785	COG3784	Protein of unknown function (DUF1318)
YPN_1787	COG2911	Protein conserved in bacteria
YPN_1788	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YPN_1789	COG3187	Heat shock protein
YPN_1790	COG3042	response to heat
YPN_1791	COG1285	pathogenesis
YPN_1793	COG0674	pyruvate-flavodoxin oxidoreductase activity
YPN_1793	COG1013	pyruvate-flavodoxin oxidoreductase activity
YPN_1793	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YPN_1793	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPN_1795	COG2755	lipolytic protein G-D-S-L family
YPN_1795	COG0657	acetylesterase activity
YPN_1799	COG4166	transmembrane transport
YPN_1800	COG2866	Carboxypeptidase
YPN_1801	COG4948	Mandelate Racemase Muconate Lactonizing
YPN_1802	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
YPN_1803	COG1943	Transposase
YPN_1808	COG3106	COG3106 Predicted ATPase
YPN_1810	COG1983	PspC domain protein
YPN_1812	COG1842	Phage shock protein A
YPN_1813	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
YPN_1815	COG4166	transmembrane transport
YPN_1816	COG4168	peptide transport system, permease
YPN_1817	COG4171	peptide transport system, permease
YPN_1819	COG4172	Belongs to the ABC transporter superfamily
YPN_1820	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPN_1820	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPN_1821	COG3104	oligopeptide transport
YPN_1824	COG0625	glutathione transferase activity
YPN_1828	COG3895	Periplasmic Protein
YPN_1830	COG3133	Outer membrane lipoprotein
YPN_1832	COG2194	sulfuric ester hydrolase activity
YPN_1833	COG1309	transcriptional regulator
YPN_1834	COG1902	pentaerythritol trinitrate reductase activity
YPN_1836	COG0346	lactoylglutathione lyase activity
YPN_1837	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YPN_1838	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
YPN_1839	COG0791	NLP P60 protein
YPN_1840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YPN_1842	COG0583	DNA-binding transcription factor activity
YPN_1843	COG2814	Major facilitator Superfamily
YPN_1844	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YPN_1845	COG0307	riboflavin synthase, alpha
YPN_1848	COG4238	major outer membrane lipoprotein
YPN_1853	COG1388	LysM domain
YPN_1853	COG1376	ErfK ybiS ycfS ynhG family protein
YPN_1856	COG0719	Fe-S assembly protein
YPN_1857	COG0396	ATPase activity
YPN_1858	COG0719	Fe-S assembly protein
YPN_1859	COG0316	Belongs to the HesB IscA family
YPN_1860	COG2050	protein possibly involved in aromatic compounds catabolism
YPN_1861	COG0277	FAD linked oxidase domain protein
YPN_1861	COG0247	lactate metabolic process
YPN_1862	COG0628	permease
YPN_1863	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YPN_1863	COG0574	Belongs to the PEP-utilizing enzyme family
YPN_1869	COG0791	NLP P60 protein
YPN_1877	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
YPN_1878	COG0386	Belongs to the glutathione peroxidase family
YPN_1881	COG0776	regulation of translation
YPN_1882	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YPN_1882	COG0072	phenylalanine-tRNA ligase activity
YPN_1883	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
YPN_1889	COG4249	Peptidase C14 caspase catalytic subunit p20
YPN_1893	COG0803	Belongs to the bacterial solute-binding protein 9 family
YPN_1894	COG1121	(ABC) transporter
YPN_1895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPN_1896	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPN_1900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPN_1901	COG3328	transposase activity
YPN_1902	COG3328	transposase activity
YPN_1904	COG1917	Cupin 2, conserved barrel domain protein
YPN_1906	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_1908	COG1175	transmembrane transport
YPN_1909	COG0395	ABC-type sugar transport system, permease component
YPN_1910	COG3842	ATPase activity
YPN_1911	COG1653	transport
YPN_1912	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YPN_1913	COG1988	membrane-bound metal-dependent
YPN_1915	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPN_1917	COG0823	Involved in the tonB-independent uptake of proteins
YPN_1918	COG2814	Major facilitator Superfamily
YPN_1919	COG3121	Chaperone
YPN_1922	COG3121	Chaperone
YPN_1923	COG3539	Fimbrial protein
YPN_1925	COG0793	Belongs to the peptidase S41A family
YPN_1927	COG1956	GAF domain-containing protein
YPN_1928	COG2995	paraquat-inducible protein a
YPN_1929	COG3008	intermembrane lipid transfer
YPN_1933	COG3121	Chaperone
YPN_1944	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YPN_1946	COG5295	Hep Hag repeat protein
YPN_1948	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPN_1950	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
YPN_1951	COG0745	RESPONSE REGULATOR receiver
YPN_1953	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YPN_1954	COG0840	transmembrane signaling receptor activity
YPN_1955	COG0840	transmembrane signaling receptor activity
YPN_1959	COG2964	Protein conserved in bacteria
YPN_1961	COG0251	oxidation-reduction process
YPN_1962	COG2271	Major facilitator Superfamily
YPN_1963	COG0835	chemotaxis
YPN_1964	COG0643	Histidine kinase
YPN_1964	COG2198	Histidine kinase
YPN_1965	COG1360	Flagellar Motor Protein
YPN_1970	COG1285	pathogenesis
YPN_1971	COG0840	transmembrane signaling receptor activity
YPN_1972	COG0840	transmembrane signaling receptor activity
YPN_1974	COG1278	Cold shock
YPN_1976	COG0604	alcohol dehydrogenase
YPN_1976	COG3321	synthase
YPN_1976	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_1979	COG1522	sequence-specific DNA binding
YPN_1985	COG1733	regulation of RNA biosynthetic process
YPN_1986	COG0702	epimerase
YPN_1987	COG0840	transmembrane signaling receptor activity
YPN_1990	COG0538	isocitrate dehydrogenase activity
YPN_1991	COG1187	pseudouridine synthase activity
YPN_1995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YPN_1997	COG0745	RESPONSE REGULATOR receiver
YPN_1999	COG2850	peptidyl-arginine hydroxylation
YPN_2001	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
YPN_2004	COG4591	ABC-type transport system involved in lipoprotein release permease component
YPN_2006	COG4591	ABC-type transport system involved in lipoprotein release permease component
YPN_2007	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
YPN_2008	COG3134	Outer membrane lipoprotein
YPN_2009	COG3328	transposase activity
YPN_2012	COG1252	NADH dehydrogenase
YPN_2014	COG1472	Belongs to the glycosyl hydrolase 3 family
YPN_2017	COG5633	Lipoprotein
YPN_2018	COG0537	adenosine 5'-monophosphoramidase activity
YPN_2019	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YPN_2021	COG1263	PTS System
YPN_2021	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPN_2022	COG0084	hydrolase, TatD family'
YPN_2023	COG0470	DNA polymerase III
YPN_2025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YPN_2026	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YPN_2028	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPN_2030	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_2034	COG0333	Belongs to the bacterial ribosomal protein bL32 family
YPN_2035	COG1399	metal-binding, possibly nucleic acid-binding protein
YPN_2037	COG0564	pseudouridine synthase activity
YPN_2038	COG1530	ribonuclease E activity
YPN_2039	COG3328	transposase activity
YPN_2043	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
YPN_2044	COG3328	transposase activity
YPN_2047	COG0628	permease
YPN_2052	COG3916	Acyl-homoserine-lactone synthase
YPN_2053	COG2771	luxR family
YPN_2054	COG0583	DNA-binding transcription factor activity
YPN_2055	COG0477	Major facilitator Superfamily
YPN_2057	COG0667	Aldo Keto reductase
YPN_2062	COG1203	CRISPR-associated helicase, Cas3
YPN_2063	COG1518	maintenance of DNA repeat elements
YPN_2064	COG0668	transmembrane transport
YPN_2068	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
YPN_2069	COG0395	ABC-type sugar transport system, permease component
YPN_2072	COG1609	Transcriptional regulator
YPN_2074	COG3842	ATPase activity
YPN_2077	COG3210	domain, Protein
YPN_2081	COG3210	domain, Protein
YPN_2084	COG3210	domain, Protein
YPN_2085	COG2831	hemolysin activation secretion protein
YPN_2086	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPN_2087	COG4638	Rieske (2fe-2S)
YPN_2088	COG4638	Rieske (2fe-2S)
YPN_2089	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YPN_2090	COG0473	3-isopropylmalate dehydrogenase activity
YPN_2091	COG0583	DNA-binding transcription factor activity
YPN_2092	COG1609	Transcriptional regulator
YPN_2093	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_2094	COG1129	ABC transporter
YPN_2095	COG1879	ABC-type sugar transport system periplasmic component
YPN_2096	COG1063	alcohol dehydrogenase
YPN_2100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
YPN_2107	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPN_2108	COG0765	amino acid transport
YPN_2109	COG1126	abc transporter atp-binding protein
YPN_2117	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YPN_2120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
YPN_2123	COG1169	isochorismate synthase
YPN_2125	COG4575	ribosome binding
YPN_2128	COG0129	dihydroxy-acid dehydratase activity
YPN_2131	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YPN_2132	COG1609	Transcriptional regulator
YPN_2134	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_2135	COG3265	gluconokinase activity
YPN_2136	COG2731	YhcH YjgK YiaL family protein
YPN_2139	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPN_2140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
YPN_2142	COG0839	Belongs to the complex I subunit 6 family
YPN_2145	COG1034	ATP synthesis coupled electron transport
YPN_2147	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
YPN_2149	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPN_2151	COG0583	DNA-binding transcription factor activity
YPN_2152	COG0436	Aminotransferase
YPN_2154	COG0490	domain, Protein
YPN_2154	COG0471	metal ion transport
YPN_2155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPN_2159	COG0280	phosphate acetyltransferase
YPN_2159	COG0857	belongs to the CobB CobQ family
YPN_2160	COG1609	Transcriptional regulator
YPN_2163	COG3328	transposase activity
YPN_2164	COG3328	transposase activity
YPN_2165	COG3037	sugar-specific permease SgaT UlaA
YPN_2166	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
YPN_2167	COG0622	Phosphoesterase
YPN_2169	COG1090	epimerase
YPN_2170	COG4598	ABC transporter
YPN_2171	COG4160	amino acid transport
YPN_2172	COG4215	(ABC) transporter
YPN_2173	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPN_2174	COG0163	prenyltransferase activity
YPN_2175	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
YPN_2176	COG1286	toxin biosynthetic process
YPN_2177	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
YPN_2178	COG0285	dihydrofolate synthase activity
YPN_2180	COG0586	Pfam SNARE associated Golgi protein
YPN_2182	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YPN_2185	COG0697	spore germination
YPN_2188	COG1794	racemase activity, acting on amino acids and derivatives
YPN_2189	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPN_2192	COG3101	peptidyl-lysine hydroxylation
YPN_2193	COG0730	response to heat
YPN_2196	COG2890	protein-(glutamine-N5) methyltransferase activity
YPN_2199	COG2062	phosphohistidine phosphatase, SixA
YPN_2202	COG3691	Protein conserved in bacteria
YPN_2205	COG4235	cytochrome complex assembly
YPN_2205	COG3088	subunit of a heme lyase
YPN_2206	COG3088	subunit of a heme lyase
YPN_2206	COG4235	cytochrome complex assembly
YPN_2207	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YPN_2208	COG1138	Cytochrome C-type biogenesis protein
YPN_2210	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPN_2211	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPN_2212	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPN_2215	COG1704	LemA family
YPN_2217	COG2824	Alkylphosphonate utilization operon protein PhnA
YPN_2222	COG3501	Rhs element vgr protein
YPN_2230	COG0395	ABC-type sugar transport system, permease component
YPN_2231	COG1175	transmembrane transport
YPN_2233	COG0673	inositol 2-dehydrogenase activity
YPN_2240	COG3328	transposase activity
YPN_2241	COG3328	transposase activity
YPN_2259	COG2197	response regulator
YPN_2261	COG3136	membrane protein required for alginate biosynthesis
YPN_2264	COG1113	amino acid transport
YPN_2267	COG2837	iron assimilation
YPN_2272	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YPN_2272	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YPN_2272	COG0506	proline dehydrogenase activity
YPN_2278	COG2515	1-aminocyclopropane-1-carboxylate deaminase
YPN_2280	COG1191	sigma factor activity
YPN_2287	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YPN_2288	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
YPN_2289	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
YPN_2292	COG1677	Flagellar hook-basal body complex protein FliE
YPN_2294	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
YPN_2296	COG1157	protein secretion by the type III secretion system
YPN_2297	COG2882	bacterial-type flagellum organization
YPN_2299	COG1580	Controls the rotational direction of flagella during chemotaxis
YPN_2304	COG1987	bacterial-type flagellum assembly
YPN_2308	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPN_2309	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_2310	COG1129	ABC transporter
YPN_2312	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_2313	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_2313	COG3347	Dehydrogenase
YPN_2314	COG2390	Transcriptional regulator
YPN_2316	COG1256	bacterial-type flagellum assembly
YPN_2320	COG4786	Flagellar basal body rod
YPN_2322	COG1749	Flagellar hook protein flgE
YPN_2323	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
YPN_2324	COG1558	bacterial-type flagellum-dependent cell motility
YPN_2325	COG1815	bacterial-type flagellum-dependent cell motility
YPN_2327	COG2747	anti-sigma28 factor FlgM
YPN_2328	COG3418	PFAM FlgN family protein
YPN_2333	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPN_2334	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPN_2339	COG2372	response to copper ion
YPN_2340	COG1528	Iron-storage protein
YPN_2343	COG1770	oligopeptidase
YPN_2346	COG3141	response to X-ray
YPN_2347	COG0513	Belongs to the DEAD box helicase family
YPN_2352	COG1760	l-serine dehydratase
YPN_2353	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YPN_2354	COG2368	4-hydroxyphenylacetate
YPN_2357	COG3971	2-oxopent-4-enoate hydratase activity
YPN_2359	COG3384	dioxygenase
YPN_2360	COG1012	belongs to the aldehyde dehydrogenase family
YPN_2363	COG1846	Transcriptional regulator
YPN_2364	COG1253	flavin adenine dinucleotide binding
YPN_2365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPN_2365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPN_2366	COG3715	PTS system
YPN_2367	COG3716	PTS system mannose fructose sorbose family IID component
YPN_2372	COG3447	MASE1 domain protein
YPN_2372	COG5002	protein histidine kinase activity
YPN_2372	COG5001	Diguanylate cyclase
YPN_2374	COG2226	methyltransferase
YPN_2376	COG1278	Cold shock
YPN_2379	COG1113	amino acid transport
YPN_2385	COG2207	Transcriptional regulator
YPN_2387	COG1132	(ABC) transporter
YPN_2396	COG3328	transposase activity
YPN_2397	COG2223	nitrite transmembrane transporter activity
YPN_2401	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YPN_2405	COG3122	Protein conserved in bacteria
YPN_2409	COG0534	Mate efflux family protein
YPN_2412	COG4948	Mandelate Racemase Muconate Lactonizing
YPN_2414	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_2415	COG3011	Protein conserved in bacteria
YPN_2416	COG2271	Major facilitator Superfamily
YPN_2418	COG1388	LysM domain
YPN_2418	COG1470	cell adhesion involved in biofilm formation
YPN_2419	COG3328	transposase activity
YPN_2422	COG2925	Exonuclease
YPN_2423	COG0531	amino acid
YPN_2424	COG0371	Dehydrogenase
YPN_2425	COG1129	ABC transporter
YPN_2426	COG1129	ABC transporter
YPN_2427	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_2429	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPN_2431	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
YPN_2433	COG0131	Imidazoleglycerol-phosphate dehydratase
YPN_2433	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YPN_2435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
YPN_2438	COG0140	phosphoribosyl-ATP diphosphatase activity
YPN_2438	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YPN_2440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YPN_2441	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YPN_2444	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YPN_2445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPN_2446	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPN_2447	COG1120	ATPase activity
YPN_2450	COG3486	L-lysine 6-monooxygenase (NADPH) activity
YPN_2451	COG0076	glutamate decarboxylase activity
YPN_2452	COG4114	ferric iron reductase
YPN_2453	COG1253	flavin adenine dinucleotide binding
YPN_2454	COG2982	Protein involved in outer membrane biogenesis
YPN_2457	COG0489	protein tyrosine kinase activity
YPN_2459	COG1943	Transposase
YPN_2464	COG2814	Major facilitator Superfamily
YPN_2466	COG1346	cytolysis
YPN_2469	COG2949	membrane
YPN_2470	COG4211	Belongs to the binding-protein-dependent transport system permease family
YPN_2473	COG2311	Membrane
YPN_2475	COG0477	Major facilitator Superfamily
YPN_2476	COG0583	DNA-binding transcription factor activity
YPN_2481	COG1136	(ABC) transporter
YPN_2483	COG0303	'Molybdopterin
YPN_2485	COG3328	transposase activity
YPN_2487	COG0488	(ABC) transporter
YPN_2515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YPN_2516	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YPN_2518	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_2519	COG1024	Enoyl-CoA hydratase
YPN_2521	COG3425	synthase
YPN_2522	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_2523	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPN_2524	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YPN_2526	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_2532	COG2920	part of a sulfur-relay system
YPN_2536	COG1832	CoA-binding protein
YPN_2537	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
YPN_2539	COG0210	DNA helicase
YPN_2540	COG3304	Inner membrane component domain
YPN_2541	COG1289	transmembrane transporter activity
YPN_2542	COG3070	regulator of competence-specific genes
YPN_2544	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
YPN_2544	COG2885	chlorophyll binding
YPN_2545	COG1943	Transposase
YPN_2547	COG1067	ATP-dependent peptidase activity
YPN_2549	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPN_2552	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPN_2553	COG1943	Transposase
YPN_2554	COG3130	regulation of translation
YPN_2555	COG3009	Protein conserved in bacteria
YPN_2556	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YPN_2556	COG3008	intermembrane lipid transfer
YPN_2557	COG2995	paraquat-inducible protein a
YPN_2558	COG0488	(ABC) transporter
YPN_2560	COG0633	Ferredoxin
YPN_2560	COG3217	Mosc domain protein beta barrel domain protein
YPN_2563	COG0308	aminopeptidase N
YPN_2567	COG1448	Aminotransferase
YPN_2568	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YPN_2569	COG3108	Peptidase M15
YPN_2570	COG2989	Protein conserved in bacteria
YPN_2573	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
YPN_2574	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
YPN_2575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YPN_2576	COG3173	Aminoglycoside phosphotransferase
YPN_2578	COG2835	tetraacyldisaccharide 4'-kinase activity
YPN_2579	COG1278	Cold shock
YPN_2580	COG5383	Protein conserved in bacteria
YPN_2583	COG0658	competence protein
YPN_2583	COG2333	competence protein COMEC
YPN_2585	COG0539	negative regulation of cytoplasmic translation
YPN_2590	COG5295	Hep Hag repeat protein
YPN_2590	COG5295	Hep Hag repeat protein
YPN_2591	COG0252	asparaginase activity
YPN_2592	COG1944	ATP diphosphatase activity
YPN_2593	COG2116	formate transmembrane transporter activity
YPN_2594	COG1882	Formate acetyltransferase
YPN_2596	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
YPN_2597	COG2814	Major facilitator Superfamily
YPN_2600	COG2814	Major facilitator Superfamily
YPN_2602	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YPN_2604	COG3107	peptidoglycan biosynthetic process
YPN_2604	COG1674	ftsk spoiiie
YPN_2606	COG0492	ferredoxin-NADP+ reductase activity
YPN_2608	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
YPN_2610	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
YPN_2612	COG0542	response to heat
YPN_2614	COG1278	Cold shock
YPN_2616	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPN_2618	COG2990	Protein conserved in bacteria
YPN_2619	COG3593	DNA synthesis involved in DNA repair
YPN_2620	COG2431	L-lysine efflux transmembrane transporter activity
YPN_2622	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPN_2623	COG0028	Belongs to the TPP enzyme family
YPN_2625	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
YPN_2626	COG0702	epimerase
YPN_2627	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPN_2630	COG1605	Chorismate mutase
YPN_2631	COG1126	abc transporter atp-binding protein
YPN_2632	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPN_2633	COG4215	(ABC) transporter
YPN_2634	COG4215	(ABC) transporter
YPN_2635	COG4160	amino acid transport
YPN_2639	COG1120	ATPase activity
YPN_2640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPN_2643	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPN_2646	COG1177	transmembrane transport
YPN_2647	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPN_2648	COG3842	ATPase activity
YPN_2649	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
YPN_2652	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YPN_2653	COG0569	domain protein
YPN_2653	COG2985	domain, Protein
YPN_2655	COG0671	phosphoesterase, PA-phosphatase related
YPN_2656	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YPN_2657	COG1349	DNA-binding transcription factor activity
YPN_2658	COG0814	amino acid
YPN_2659	COG1686	Belongs to the peptidase S11 family
YPN_2660	COG2011	ABC-type metal ion transport system permease component
YPN_2665	COG0625	glutathione transferase activity
YPN_2666	COG4771	TonB-dependent receptor
YPN_2668	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPN_2670	COG0833	amino acid
YPN_2671	COG0583	DNA-binding transcription factor activity
YPN_2672	COG2855	membrane
YPN_2674	COG3188	usher protein
YPN_2675	COG3121	Chaperone
YPN_2678	COG3710	Transcriptional regulator
YPN_2679	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPN_2679	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
YPN_2679	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPN_2680	COG1105	Belongs to the carbohydrate kinase PfkB family
YPN_2682	COG0494	nUDIX hydrolase
YPN_2683	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_2684	COG1129	ABC transporter
YPN_2686	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YPN_2691	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_2695	COG1312	Catalyzes the dehydration of D-mannonate
YPN_2696	COG0246	Mannitol dehydrogenase
YPN_2697	COG2186	Transcriptional regulator
YPN_2699	COG0523	cobalamin synthesis protein
YPN_2700	COG0671	phosphoesterase, PA-phosphatase related
YPN_2701	COG0791	NLP P60 protein
YPN_2702	COG2200	EAL domain
YPN_2703	COG4166	transmembrane transport
YPN_2704	COG4174	ABC transporter (Permease)
YPN_2705	COG4239	(ABC) transporter, permease
YPN_2706	COG4172	Belongs to the ABC transporter superfamily
YPN_2709	COG2814	Major facilitator Superfamily
YPN_2710	COG1187	pseudouridine synthase activity
YPN_2711	COG1061	Type III restriction enzyme res subunit
YPN_2713	COG1943	Transposase
YPN_2715	COG3082	Protein of unknown function (DUF1414)
YPN_2716	COG3083	sulfuric ester hydrolase activity
YPN_2718	COG3157	Type VI secretion system effector, Hcp
YPN_2722	COG2723	6-phospho-beta-galactosidase activity
YPN_2723	COG1737	Transcriptional regulator
YPN_2727	COG3299	homolog of phage Mu protein gp47
YPN_2736	COG4386	tail sheath protein
YPN_2740	COG3622	Belongs to the hyi family
YPN_2741	COG1349	DNA-binding transcription factor activity
YPN_2742	COG0235	Class ii aldolase
YPN_2743	COG3395	kinase activity
YPN_2753	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
YPN_2755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
YPN_2756	COG2223	nitrite transmembrane transporter activity
YPN_2757	COG2198	Histidine kinase
YPN_2757	COG0642	Histidine kinase
YPN_2758	COG2198	Histidine kinase
YPN_2758	COG0642	Histidine kinase
YPN_2760	COG0784	Response regulator, receiver
YPN_2760	COG2205	protein histidine kinase activity
YPN_2765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPN_2768	COG0814	amino acid
YPN_2773	COG0697	spore germination
YPN_2775	COG1982	Orn Lys Arg decarboxylase major
YPN_2776	COG0531	amino acid
YPN_2777	COG1174	glycine betaine transport
YPN_2778	COG1125	glycine betaine transport
YPN_2779	COG1174	glycine betaine transport
YPN_2780	COG1732	Glycine betaine
YPN_2781	COG1732	Glycine betaine
YPN_2782	COG2897	thiosulfate sulfurtransferase activity
YPN_2785	COG0410	ABC transporter
YPN_2786	COG1122	ATPase activity
YPN_2790	COG4807	Protein conserved in bacteria
YPN_2793	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
YPN_2795	COG2261	transglycosylase associated protein
YPN_2798	COG1403	HNH endonuclease
YPN_2800	COG0277	FAD linked oxidase domain protein
YPN_2801	COG1686	Belongs to the peptidase S11 family
YPN_2803	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPN_2806	COG0513	Belongs to the DEAD box helicase family
YPN_2808	COG3328	transposase activity
YPN_2814	COG0513	Belongs to the DEAD box helicase family
YPN_2815	COG1309	transcriptional regulator
YPN_2817	COG1131	(ABC) transporter
YPN_2818	COG0842	Transport permease protein
YPN_2819	COG0842	Transport permease protein
YPN_2823	COG1902	pentaerythritol trinitrate reductase activity
YPN_2827	COG2211	Major facilitator Superfamily
YPN_2829	COG2211	Major facilitator Superfamily
YPN_2830	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
YPN_2832	COG0583	DNA-binding transcription factor activity
YPN_2833	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YPN_2837	COG1943	Transposase
YPN_2838	COG0670	Belongs to the BI1 family
YPN_2839	COG0314	molybdopterin synthase activity
YPN_2840	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
YPN_2842	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YPN_2843	COG0391	Required for morphogenesis under gluconeogenic growth conditions
YPN_2844	COG4628	conserved protein (DUF2132)
YPN_2845	COG0556	nucleotide-excision repair
YPN_2847	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YPN_2848	COG2226	methyltransferase
YPN_2853	COG0561	phosphatase activity
YPN_2855	COG4149	molybdate abc transporter
YPN_2856	COG0725	ABC transporter, periplasmic molybdate-binding protein
YPN_2858	COG3585	molybdate ion transport
YPN_2858	COG2005	Transcriptional regulator
YPN_2859	COG1119	ATPase activity
YPN_2861	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YPN_2862	COG1085	galactose-1-phosphate uridylyltransferase
YPN_2865	COG2017	converts alpha-aldose to the beta-anomer
YPN_2868	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YPN_2869	COG1230	cation diffusion facilitator family transporter
YPN_2872	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
YPN_2873	COG2885	chlorophyll binding
YPN_2875	COG3064	Membrane
YPN_2875	COG3064	Membrane
YPN_2876	COG0848	biopolymer transport protein
YPN_2877	COG0811	peptide transport
YPN_2878	COG0824	Thioesterase
YPN_2879	COG3790	cyd operon protein YbgE
YPN_2880	COG1294	oxidase, subunit
YPN_2881	COG1271	oxidase subunit
YPN_2882	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
YPN_2884	COG0508	dehydrogenase complex catalyzes the overall conversion of
YPN_2885	COG0567	Dehydrogenase, E1 component
YPN_2887	COG1053	succinate dehydrogenase
YPN_2888	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
YPN_2889	COG2009	succinate dehydrogenase
YPN_2892	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YPN_2893	COG0497	DNA recombination
YPN_2894	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPN_2896	COG2867	negative regulation of translational initiation
YPN_2899	COG0582	viral genome integration into host DNA
YPN_2910	COG3657	addiction module killer protein
YPN_2915	COG1953	Uracil, thiamine, allantoin
YPN_2916	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YPN_2918	COG2226	methyltransferase
YPN_2920	COG0741	lytic transglycosylase activity
YPN_2920	COG1388	LysM domain
YPN_2923	COG0656	L-ascorbic acid biosynthetic process
YPN_2925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YPN_2927	COG2011	ABC-type metal ion transport system permease component
YPN_2928	COG1464	Belongs to the NlpA lipoprotein family
YPN_2930	COG1720	tRNA m6t6A37 methyltransferase activity
YPN_2932	COG3015	lipoprotein NlpE involved in copper resistance
YPN_2934	COG4681	YaeQ
YPN_2936	COG4568	rho-dependent transcription termination
YPN_2938	COG0037	tRNA processing
YPN_2939	COG0346	lactoylglutathione lyase activity
YPN_2941	COG0587	DNA-directed DNA polymerase activity
YPN_2943	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YPN_2947	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
YPN_2949	COG0750	zinc metalloprotease
YPN_2950	COG0575	Belongs to the CDS family
YPN_2951	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
YPN_2958	COG0024	Methionine aminopeptidase
YPN_2964	COG0564	pseudouridine synthase activity
YPN_2965	COG3098	single-species biofilm formation
YPN_2966	COG1943	Transposase
YPN_2969	COG1611	Belongs to the LOG family
YPN_2970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPN_2972	COG2363	Small membrane protein
YPN_2973	COG0583	DNA-binding transcription factor activity
YPN_2974	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YPN_2975	COG2166	iron-sulfur cluster assembly
YPN_2976	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
YPN_2977	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
YPN_2978	COG0860	N-Acetylmuramoyl-L-alanine amidase
YPN_2980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
YPN_2981	COG1074	ATP-dependent DNA helicase activity
YPN_2983	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
YPN_2993	COG0667	Aldo Keto reductase
YPN_2999	COG1609	Transcriptional regulator
YPN_3000	COG0019	diaminopimelate decarboxylase activity
YPN_3001	COG0583	DNA-binding transcription factor activity
YPN_3002	COG2814	Major facilitator Superfamily
YPN_3003	COG0583	DNA-binding transcription factor activity
YPN_3006	COG0840	transmembrane signaling receptor activity
YPN_3015	COG2165	general secretion pathway protein
YPN_3023	COG0288	reversible hydration of carbon dioxide
YPN_3031	COG1943	Transposase
YPN_3032	COG3119	arylsulfatase activity
YPN_3033	COG1349	DNA-binding transcription factor activity
YPN_3035	COG2222	sugar isomerase
YPN_3036	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPN_3037	COG3715	PTS system
YPN_3038	COG3716	PTS system mannose fructose sorbose family IID component
YPN_3039	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPN_3041	COG1028	Short-chain dehydrogenase reductase Sdr
YPN_3043	COG0641	radical SAM
YPN_3044	COG3119	arylsulfatase activity
YPN_3046	COG0191	fructose-bisphosphate aldolase activity
YPN_3049	COG2271	Major facilitator Superfamily
YPN_3053	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPN_3053	COG1263	PTS System
YPN_3054	COG1874	Beta-galactosidase
YPN_3055	COG3867	Arabinogalactan endo-beta-1,4-galactanase
YPN_3056	COG3833	ABC-type maltose transport systems, permease component
YPN_3057	COG1175	transmembrane transport
YPN_3058	COG2182	Extracellular solute-binding protein
YPN_3060	COG1129	ABC transporter
YPN_3061	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_3062	COG1879	ABC-type sugar transport system periplasmic component
YPN_3064	COG0791	NLP P60 protein
YPN_3065	COG1695	Transcriptional regulator
YPN_3080	COG2944	sequence-specific DNA binding
YPN_3086	COG0582	viral genome integration into host DNA
YPN_3089	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
YPN_3090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YPN_3091	COG4974	Belongs to the 'phage' integrase family
YPN_3092	COG0716	FMN binding
YPN_3093	COG4452	Inner membrane protein CreD
YPN_3094	COG2205	protein histidine kinase activity
YPN_3095	COG0745	RESPONSE REGULATOR receiver
YPN_3097	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
YPN_3100	COG1272	protein, Hemolysin III
YPN_3102	COG5295	Hep Hag repeat protein
YPN_3107	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPN_3108	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPN_3109	COG0006	proline dipeptidase activity
YPN_3112	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YPN_3113	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YPN_3114	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YPN_3119	COG0191	fructose-bisphosphate aldolase activity
YPN_3123	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
YPN_3124	COG0501	Belongs to the peptidase M48B family
YPN_3126	COG1166	arginine decarboxylase activity
YPN_3129	COG2356	endonuclease I
YPN_3131	COG1385	rRNA (uridine-N3-)-methyltransferase activity
YPN_3132	COG0189	ligase activity
YPN_3135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPN_3137	COG2805	Type II/IV secretion system protein
YPN_3138	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
YPN_3139	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
YPN_3140	COG0762	integral membrane protein
YPN_3142	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
YPN_3143	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YPN_3144	COG3064	Membrane
YPN_3144	COG1073	alpha beta
YPN_3144	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
YPN_3147	COG2066	Belongs to the glutaminase family
YPN_3148	COG3171	Protein conserved in bacteria
YPN_3150	COG1194	a g-specific adenine glycosylase
YPN_3154	COG4774	siderophore transport
YPN_3155	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_3156	COG1129	ABC transporter
YPN_3157	COG1879	ABC-type sugar transport system periplasmic component
YPN_3158	COG1982	Orn Lys Arg decarboxylase major
YPN_3162	COG1662	PFAM IS1 transposase
YPN_3182	COG3916	Acyl-homoserine-lactone synthase
YPN_3183	COG2771	luxR family
YPN_3193	COG2211	Major facilitator Superfamily
YPN_3195	COG2801	Transposase and inactivated derivatives
YPN_3198	COG0471	metal ion transport
YPN_3201	COG3209	COG3209 Rhs family protein
YPN_3203	COG3501	Rhs element vgr protein
YPN_3207	COG2610	gluconate transmembrane transporter activity
YPN_3210	COG1132	(ABC) transporter
YPN_3216	COG3433	isochorismatase activity
YPN_3216	COG2226	methyltransferase
YPN_3216	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPN_3217	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPN_3218	COG3433	isochorismatase activity
YPN_3218	COG2226	methyltransferase
YPN_3218	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPN_3222	COG4771	TonB-dependent receptor
YPN_3223	COG2195	Cleaves the N-terminal amino acid of tripeptides
YPN_3224	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
YPN_3232	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPN_3234	COG3300	MHYT domain
YPN_3234	COG5001	Diguanylate cyclase
YPN_3235	COG2801	Transposase and inactivated derivatives
YPN_3241	COG0195	Participates in both transcription termination and antitermination
YPN_3243	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
YPN_3245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YPN_3246	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YPN_3248	COG1534	Rna-binding protein
YPN_3249	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPN_3250	COG2027	D-alanyl-D-alanine carboxypeptidase
YPN_3251	COG0745	RESPONSE REGULATOR receiver
YPN_3252	COG0642	Histidine kinase
YPN_3254	COG0697	spore germination
YPN_3257	COG0142	geranyltranstransferase activity
YPN_3259	COG3423	Transcriptional regulator
YPN_3263	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YPN_3265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YPN_3266	COG2105	PFAM AIG2 family protein
YPN_3267	COG2911	Protein conserved in bacteria
YPN_3268	COG0729	surface antigen
YPN_3270	COG1253	flavin adenine dinucleotide binding
YPN_3272	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
YPN_3274	COG0737	Belongs to the 5'-nucleotidase family
YPN_3276	COG0545	Peptidyl-prolyl cis-trans isomerase
YPN_3277	COG3061	Opacity-associated protein A
YPN_3279	COG1943	Transposase
YPN_3281	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
YPN_3283	COG0360	Binds together with S18 to 16S ribosomal RNA
YPN_3284	COG1073	alpha beta
YPN_3288	COG3650	response to hydrogen peroxide
YPN_3289	COG1960	acyl-CoA dehydrogenase activity
YPN_3290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPN_3291	COG0557	exoribonuclease II activity
YPN_3294	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
YPN_3295	COG0330	HflC and HflK could
YPN_3296	COG0330	HflC and HflK could
YPN_3297	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YPN_3301	COG0860	N-Acetylmuramoyl-L-alanine amidase
YPN_3302	COG0802	atpase or kinase
YPN_3303	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YPN_3303	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
YPN_3304	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
YPN_3305	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
YPN_3308	COG3264	Mechanosensitive ion channel
YPN_3308	COG1511	domain protein
YPN_3311	COG1053	succinate dehydrogenase
YPN_3312	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
YPN_3314	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
YPN_3315	COG2076	Multidrug Resistance protein
YPN_3323	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPN_3326	COG3383	formate dehydrogenase (NAD+) activity
YPN_3327	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPN_3328	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPN_3328	COG0493	'glutamate synthase
YPN_3329	COG1309	transcriptional regulator
YPN_3343	COG1454	alcohol dehydrogenase
YPN_3345	COG0629	single-stranded DNA binding
YPN_3346	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YPN_3347	COG2315	Protein conserved in bacteria
YPN_3348	COG1448	Aminotransferase
YPN_3349	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YPN_3350	COG0305	Participates in initiation and elongation during chromosome replication
YPN_3353	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPN_3354	COG0735	belongs to the Fur family
YPN_3356	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
YPN_3364	COG3121	Chaperone
YPN_3376	COG1358	cellular component organization or biogenesis
YPN_3381	COG3721	Heme iron utilization protein
YPN_3382	COG0702	epimerase
YPN_3384	COG4771	TonB-dependent receptor
YPN_3385	COG3720	iron ion transport
YPN_3386	COG4558	Periplasmic binding protein
YPN_3387	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPN_3389	COG0626	cystathionine gamma-synthase activity
YPN_3390	COG0814	amino acid
YPN_3391	COG0583	DNA-binding transcription factor activity
YPN_3392	COG0425	Belongs to the sulfur carrier protein TusA family
YPN_3393	COG2391	methyltransferase activity
YPN_3415	COG1301	dicarboxylic acid transport
YPN_3417	COG3162	membrane
YPN_3422	COG2801	Transposase and inactivated derivatives
YPN_3427	COG0435	Glutathione S-transferase
YPN_3428	COG0583	DNA-binding transcription factor activity
YPN_3429	COG1741	Belongs to the pirin family
YPN_3430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
YPN_3434	COG2823	Periplasmic or secreted lipoprotein
YPN_3436	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
YPN_3437	COG0784	Response regulator, receiver
YPN_3437	COG5002	protein histidine kinase activity
YPN_3437	COG2198	Histidine kinase
YPN_3438	COG1242	4 iron, 4 sulfur cluster binding
YPN_3439	COG0069	glutamate synthase activity
YPN_3439	COG0070	glutamate synthase
YPN_3439	COG0067	glutamate synthase
YPN_3440	COG0493	'glutamate synthase
YPN_3442	COG2969	positive regulation of protein catabolic process
YPN_3443	COG0625	glutathione transferase activity
YPN_3446	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YPN_3447	COG3105	Protein conserved in bacteria
YPN_3448	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPN_3449	COG1943	Transposase
YPN_3450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPN_3452	COG5007	Belongs to the BolA IbaG family
YPN_3453	COG3113	response to antibiotic
YPN_3454	COG2854	intermembrane phospholipid transfer
YPN_3455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YPN_3456	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YPN_3457	COG1127	ABC transporter
YPN_3458	COG0530	calcium, potassium:sodium antiporter activity
YPN_3459	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
YPN_3459	COG0517	IMP dehydrogenase activity
YPN_3460	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
YPN_3461	COG3117	lipopolysaccharide transmembrane transporter activity
YPN_3462	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
YPN_3463	COG1137	ATPase activity
YPN_3464	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
YPN_3466	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
YPN_3467	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPN_3469	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPN_3474	COG1609	Transcriptional regulator
YPN_3475	COG1263	PTS System
YPN_3475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPN_3476	COG0366	Alpha amylase catalytic
YPN_3477	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPN_3478	COG3783	Cytochrome b(562)
YPN_3480	COG0312	modulator of DNA gyrase
YPN_3482	COG2732	(Barnase) inhibitor
YPN_3485	COG1012	belongs to the aldehyde dehydrogenase family
YPN_3489	COG0583	DNA-binding transcription factor activity
YPN_3499	COG0312	modulator of DNA gyrase
YPN_3500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPN_3501	COG3164	Protein of unknown function
YPN_3502	COG1530	ribonuclease E activity
YPN_3504	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
YPN_3505	COG1792	Involved in formation and maintenance of cell shape
YPN_3506	COG1077	Cell shape determining protein MreB Mrl
YPN_3507	COG2200	EAL domain
YPN_3507	COG2199	diguanylate cyclase activity
YPN_3508	COG0604	alcohol dehydrogenase
YPN_3509	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
YPN_3512	COG0511	ligase activity, forming carbon-carbon bonds
YPN_3513	COG0439	Biotin carboxylase
YPN_3514	COG3924	membrane
YPN_3515	COG4145	pantothenate transmembrane transporter activity
YPN_3517	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPN_3518	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
YPN_3522	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPN_3524	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YPN_3525	COG3133	Outer membrane lipoprotein
YPN_3526	COG1278	Cold shock
YPN_3527	COG1278	Cold shock
YPN_3528	COG1943	Transposase
YPN_3531	COG0625	glutathione transferase activity
YPN_3533	COG1069	ribulokinase activity
YPN_3535	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_3536	COG1129	ABC transporter
YPN_3538	COG1560	Kdo2-lipid A biosynthetic process
YPN_3540	COG0025	NhaP-type Na H and K H
YPN_3541	COG2252	PERMEase
YPN_3542	COG3077	Addiction module antitoxin, RelB DinJ family
YPN_3544	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPN_3546	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YPN_3547	COG0431	NADPH-dependent FMN reductase
YPN_3549	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPN_3550	COG1869	D-ribose catabolic process
YPN_3551	COG2207	Transcriptional regulator
YPN_3551	COG1917	Cupin 2, conserved barrel domain protein
YPN_3552	COG0673	inositol 2-dehydrogenase activity
YPN_3555	COG3209	COG3209 Rhs family protein
YPN_3557	COG3501	Rhs element vgr protein
YPN_3563	COG3209	COG3209 Rhs family protein
YPN_3566	COG3501	Rhs element vgr protein
YPN_3581	COG2801	Transposase and inactivated derivatives
YPN_3585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YPN_3586	COG0058	SHG alpha-glucan phosphorylase activity
YPN_3588	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
YPN_3591	COG3275	phosphorelay sensor kinase activity
YPN_3597	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YPN_3598	COG2095	MarC family integral membrane protein
YPN_3602	COG3265	gluconokinase activity
YPN_3603	COG2610	gluconate transmembrane transporter activity
YPN_3604	COG1609	Transcriptional regulator
YPN_3605	COG1741	Belongs to the pirin family
YPN_3607	COG0745	RESPONSE REGULATOR receiver
YPN_3609	COG0191	fructose-bisphosphate aldolase activity
YPN_3611	COG1879	ABC-type sugar transport system periplasmic component
YPN_3612	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPN_3615	COG2081	HI0933 family
YPN_3616	COG0306	phosphate transporter
YPN_3619	COG0589	response to stress
YPN_3623	COG0339	signal peptide processing
YPN_3625	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
YPN_3626	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPN_3627	COG3835	regulator
YPN_3629	COG2610	gluconate transmembrane transporter activity
YPN_3630	COG1929	Belongs to the glycerate kinase type-1 family
YPN_3635	COG1295	ribonuclease BN
YPN_3636	COG2134	cdp-diacylglycerol pyrophosphatase
YPN_3637	COG2982	Protein involved in outer membrane biogenesis
YPN_3638	COG2200	EAL domain
YPN_3639	COG1942	4-Oxalocrotonate Tautomerase
YPN_3640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPN_3641	COG0612	Peptidase, M16
YPN_3645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YPN_3646	COG2200	EAL domain
YPN_3646	COG2199	diguanylate cyclase activity
YPN_3647	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
YPN_3648	COG4608	Belongs to the ABC transporter superfamily
YPN_3649	COG0444	Belongs to the ABC transporter superfamily
YPN_3650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPN_3651	COG0601	transmembrane transport
YPN_3652	COG0747	negative chemotaxis
YPN_3653	COG2831	hemolysin activation secretion protein
YPN_3655	COG2271	Major facilitator Superfamily
YPN_3659	COG3851	Histidine kinase
YPN_3660	COG2197	response regulator
YPN_3661	COG2194	sulfuric ester hydrolase activity
YPN_3664	COG2986	histidine ammonia-lyase
YPN_3667	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YPN_3670	COG4607	ABC-type enterochelin transport system periplasmic component
YPN_3672	COG4605	iron ion homeostasis
YPN_3673	COG4604	ABC transporter, ATP-binding protein
YPN_3680	COG0582	viral genome integration into host DNA
YPN_3681	COG1609	Transcriptional regulator
YPN_3681	COG2207	Transcriptional regulator
YPN_3682	COG4214	carbohydrate transport
YPN_3684	COG4213	ABC transporter substrate-binding protein
YPN_3686	COG1070	Carbohydrate kinase
YPN_3688	COG3121	Chaperone
YPN_3689	COG3188	usher protein
YPN_3690	COG3188	usher protein
YPN_3692	COG3274	enterobacterial common antigen metabolic process
YPN_3694	COG2801	Transposase and inactivated derivatives
YPN_3700	COG3276	selenocysteine insertion sequence binding
YPN_3703	COG2864	formate dehydrogenase
YPN_3704	COG0437	4 iron, 4 sulfur cluster binding
YPN_3705	COG3383	formate dehydrogenase (NAD+) activity
YPN_3705	COG0243	molybdopterin cofactor binding
YPN_3706	COG3383	formate dehydrogenase (NAD+) activity
YPN_3706	COG0243	molybdopterin cofactor binding
YPN_3708	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YPN_3713	COG3722	fumarate hydratase activity
YPN_3715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPN_3715	COG2213	PTS system mannitol-specific
YPN_3719	COG2818	Glycosylase
YPN_3721	COG2885	chlorophyll binding
YPN_3724	COG0366	Alpha amylase catalytic
YPN_3726	COG3977	Valine--pyruvate aminotransferase
YPN_3730	COG5645	(Lipo)protein
YPN_3731	COG0823	Involved in the tonB-independent uptake of proteins
YPN_3732	COG0823	Involved in the tonB-independent uptake of proteins
YPN_3733	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YPN_3734	COG2423	ornithine cyclodeaminase activity
YPN_3736	COG2801	Transposase and inactivated derivatives
YPN_3738	COG0527	aspartate kinase activity
YPN_3738	COG0460	homoserine dehydrogenase
YPN_3739	COG0626	cystathionine gamma-synthase activity
YPN_3740	COG0626	cystathionine gamma-synthase activity
YPN_3742	COG4682	membrane
YPN_3744	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YPN_3745	COG1609	Transcriptional regulator
YPN_3746	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YPN_3749	COG1575	Belongs to the MenA family. Type 1 subfamily
YPN_3757	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YPN_3758	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YPN_3759	COG1494	fructose-1,6-bisphosphatase
YPN_3761	COG3152	Membrane
YPN_3764	COG0583	DNA-binding transcription factor activity
YPN_3765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YPN_3766	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YPN_3767	COG0471	metal ion transport
YPN_3769	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
YPN_3775	COG4974	Belongs to the 'phage' integrase family
YPN_3776	COG3678	ATP-independent chaperone mediated protein folding
YPN_3777	COG0745	RESPONSE REGULATOR receiver
YPN_3778	COG2205	protein histidine kinase activity
YPN_3779	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YPN_3779	COG2169	Transcriptional regulator
YPN_3780	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
YPN_3781	COG1045	serine acetyltransferase
YPN_3784	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YPN_3785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YPN_3787	COG4942	peptidase
YPN_3788	COG2861	carbohydrate metabolic process
YPN_3789	COG2861	carbohydrate metabolic process
YPN_3791	COG0156	8-amino-7-oxononanoate synthase activity
YPN_3793	COG0859	PFAM glycosyl transferase family 9
YPN_3794	COG0859	PFAM glycosyl transferase family 9
YPN_3795	COG1519	Transferase
YPN_3799	COG0267	Belongs to the bacterial ribosomal protein bL33 family
YPN_3802	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YPN_3807	COG1561	YicC-like family, N-terminal region
YPN_3808	COG2860	membrane
YPN_3809	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YPN_3812	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YPN_3813	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPN_3814	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YPN_3815	COG0786	glutamate:sodium symporter activity
YPN_3816	COG2233	PERMEase
YPN_3817	COG2982	Protein involved in outer membrane biogenesis
YPN_3818	COG0456	acetyltransferase
YPN_3821	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YPN_3824	COG0551	DNA topoisomerase type I activity
YPN_3826	COG0758	DNA mediated transformation
YPN_3830	COG0569	domain protein
YPN_3832	COG3036	rescue of stalled ribosome
YPN_3833	COG0789	Transcriptional regulator
YPN_3836	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YPN_3839	COG0201	protein transport
YPN_3841	COG1841	ribosomal large subunit assembly
YPN_3849	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YPN_3850	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
YPN_3852	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YPN_3853	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YPN_3855	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YPN_3860	COG0051	transcription antitermination factor activity, RNA binding
YPN_3863	COG1943	Transposase
YPN_3866	COG0049	tRNA binding
YPN_3867	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
YPN_3871	COG2964	Protein conserved in bacteria
YPN_3872	COG0545	Peptidyl-prolyl cis-trans isomerase
YPN_3874	COG1047	Peptidyl-prolyl cis-trans
YPN_3875	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
YPN_3878	COG0488	(ABC) transporter
YPN_3879	COG0488	(ABC) transporter
YPN_3880	COG1216	Glycosyl transferase, family 2
YPN_3882	COG2175	clavaminate synthase activity
YPN_3883	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPN_3885	COG4521	taurine ABC transporter
YPN_3887	COG0429	hydrolase of the alpha beta-hydrolase fold
YPN_3889	COG3954	Phosphoribulokinase
YPN_3891	COG1765	OsmC-like protein
YPN_3893	COG1289	transmembrane transporter activity
YPN_3896	COG0433	COG0433 Predicted ATPase
YPN_3897	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YPN_3898	COG1486	melibiose metabolic process
YPN_3902	COG0402	S-adenosylhomocysteine deaminase activity
YPN_3903	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YPN_3904	COG2146	nitrite reductase [NAD(P)H] activity
YPN_3908	COG0180	Tryptophanyl-tRNA synthetase
YPN_3909	COG0546	phosphoglycolate phosphatase activity
YPN_3910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
YPN_3915	COG4796	Type ii and iii secretion system protein
YPN_3921	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
YPN_3922	COG0494	nUDIX hydrolase
YPN_3924	COG1011	Hydrolase
YPN_3925	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
YPN_3929	COG0745	RESPONSE REGULATOR receiver
YPN_3930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPN_3931	COG2183	response to ionizing radiation
YPN_3932	COG1918	ferrous iron import across plasma membrane
YPN_3939	COG1640	4-alpha-glucanotransferase
YPN_3940	COG0058	SHG alpha-glucan phosphorylase activity
YPN_3941	COG0058	SHG alpha-glucan phosphorylase activity
YPN_3948	COG1349	DNA-binding transcription factor activity
YPN_3950	COG2801	Transposase and inactivated derivatives
YPN_3951	COG0561	phosphatase activity
YPN_3952	COG0187	DNA topoisomerase II activity
YPN_3953	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YPN_3954	COG0592	DNA-directed DNA polymerase activity
YPN_3956	COG0230	Belongs to the bacterial ribosomal protein bL34 family
YPN_3959	COG0706	membrane insertase activity
YPN_3964	COG2252	PERMEase
YPN_3965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPN_3966	COG0765	amino acid transport
YPN_3967	COG0765	amino acid transport
YPN_3968	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPN_3970	COG0704	Plays a role in the regulation of phosphate uptake
YPN_3972	COG0581	inorganic phosphate transmembrane transporter activity
YPN_3973	COG0573	inorganic phosphate transmembrane transporter activity
YPN_3974	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YPN_3975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YPN_3985	COG3312	ion transport
YPN_MT0003	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
YPN_MT0004	COG5301	cellulose 1,4-beta-cellobiosidase activity
YPN_MT0004	COG5301	cellulose 1,4-beta-cellobiosidase activity
YPN_MT0011	COG3941	tape measure
YPN_MT0031	COG1475	DNA binding
YPN_MT0032	COG1475	DNA binding
YPN_MT0033	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YPN_MT0044	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YPN_MT0052	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
YPN_MT0054	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPN_MT0075	COG3328	transposase activity
YPN_MT0078	COG3344	reverse transcriptase
YPN_MT0080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YPN_MT0094	COG1475	DNA binding
YPN_PCP0007	COG4683	PFAM Phage derived protein Gp49-like (DUF891)