locus-tag	class	description
CH59_1	COG0477	Major facilitator Superfamily
CH59_10	COG0668	transmembrane transport
CH59_1003	COG1695	Transcriptional regulator
CH59_1004	COG0791	NLP P60 protein
CH59_1006	COG1879	ABC-type sugar transport system periplasmic component
CH59_1007	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_1008	COG1129	ABC transporter
CH59_1010	COG2182	Extracellular solute-binding protein
CH59_1011	COG1175	transmembrane transport
CH59_1012	COG3833	ABC-type maltose transport systems, permease component
CH59_1013	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CH59_1014	COG1874	Beta-galactosidase
CH59_1015	COG1263	PTS System
CH59_1015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH59_1019	COG2271	Major facilitator Superfamily
CH59_1023	COG0191	fructose-bisphosphate aldolase activity
CH59_1025	COG3119	arylsulfatase activity
CH59_1026	COG0641	radical SAM
CH59_1028	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_103	COG1943	Transposase
CH59_1030	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH59_1031	COG3716	PTS system mannose fructose sorbose family IID component
CH59_1032	COG3715	PTS system
CH59_1033	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH59_1034	COG2222	sugar isomerase
CH59_1036	COG1349	DNA-binding transcription factor activity
CH59_1037	COG3119	arylsulfatase activity
CH59_1038	COG1943	Transposase
CH59_104	COG1609	Transcriptional regulator
CH59_1043	COG0288	reversible hydration of carbon dioxide
CH59_1062	COG0840	transmembrane signaling receptor activity
CH59_1064	COG0583	DNA-binding transcription factor activity
CH59_1065	COG0583	DNA-binding transcription factor activity
CH59_1066	COG2814	Major facilitator Superfamily
CH59_1067	COG1609	Transcriptional regulator
CH59_1068	COG0019	diaminopimelate decarboxylase activity
CH59_107	COG3328	transposase activity
CH59_1074	COG0667	Aldo Keto reductase
CH59_108	COG1917	Cupin 2, conserved barrel domain protein
CH59_1085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH59_1085	COG2226	methyltransferase
CH59_1085	COG3433	isochorismatase activity
CH59_1086	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH59_1087	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH59_1087	COG2226	methyltransferase
CH59_1087	COG3433	isochorismatase activity
CH59_1093	COG1132	(ABC) transporter
CH59_1097	COG2610	gluconate transmembrane transporter activity
CH59_110	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_1101	COG3501	Rhs element vgr protein
CH59_1103	COG3209	COG3209 Rhs family protein
CH59_1106	COG0471	metal ion transport
CH59_1108	COG2801	Transposase and inactivated derivatives
CH59_1111	COG3133	Outer membrane lipoprotein
CH59_1116	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CH59_1117	COG1191	sigma factor activity
CH59_112	COG1175	transmembrane transport
CH59_1122	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CH59_1126	COG3710	Transcriptional regulator
CH59_113	COG0395	ABC-type sugar transport system, permease component
CH59_1130	COG1256	bacterial-type flagellum assembly
CH59_1132	COG1706	bacterial-type flagellum-dependent cell motility
CH59_1133	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CH59_1134	COG4786	Flagellar basal body rod
CH59_1136	COG1943	Transposase
CH59_1138	COG1749	Flagellar hook protein flgE
CH59_1139	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH59_114	COG3842	ATPase activity
CH59_1140	COG1558	bacterial-type flagellum-dependent cell motility
CH59_1141	COG1815	bacterial-type flagellum-dependent cell motility
CH59_1142	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CH59_115	COG1653	transport
CH59_1151	COG2204	response regulator
CH59_1155	COG1987	bacterial-type flagellum assembly
CH59_1156	COG1684	flagellar biosynthetic protein fliR
CH59_1157	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH59_116	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH59_1162	COG4592	Periplasmic binding protein
CH59_1166	COG1943	Transposase
CH59_1167	COG1943	Transposase
CH59_117	COG1988	membrane-bound metal-dependent
CH59_1170	COG4964	Belongs to the GSP D family
CH59_1171	COG4964	Belongs to the GSP D family
CH59_1181	COG0848	biopolymer transport protein
CH59_1183	COG0811	peptide transport
CH59_1184	COG0626	cystathionine gamma-synthase activity
CH59_1185	COG0586	Pfam SNARE associated Golgi protein
CH59_1186	COG2207	Transcriptional regulator
CH59_1187	COG1979	alcohol dehydrogenase
CH59_1188	COG0656	L-ascorbic acid biosynthetic process
CH59_119	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH59_1191	COG2132	Multicopper oxidase
CH59_1192	COG0204	Acyl-transferase
CH59_1193	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH59_1194	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH59_1195	COG0583	DNA-binding transcription factor activity
CH59_1196	COG0187	DNA topoisomerase II activity
CH59_1197	COG3150	esterase
CH59_1198	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH59_1199	COG3151	Protein conserved in bacteria
CH59_1200	COG0494	nUDIX hydrolase
CH59_1201	COG1538	Outer membrane efflux protein
CH59_1204	COG0754	glutathionylspermidine amidase activity
CH59_1205	COG3384	dioxygenase
CH59_1209	COG0531	amino acid
CH59_121	COG0823	Involved in the tonB-independent uptake of proteins
CH59_1212	COG3025	triphosphatase activity
CH59_1213	COG4991	sh3 domain protein
CH59_1216	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH59_122	COG2814	Major facilitator Superfamily
CH59_1220	COG0358	DNA primase activity
CH59_1221	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH59_123	COG3121	Chaperone
CH59_1238	COG0251	oxidation-reduction process
CH59_1243	COG1943	Transposase
CH59_1247	COG1289	transmembrane transporter activity
CH59_1251	COG0395	ABC-type sugar transport system, permease component
CH59_1253	COG1653	transport
CH59_1254	COG1609	Transcriptional regulator
CH59_1255	COG3459	Glycosyltransferase 36 associated
CH59_1256	COG3842	ATPase activity
CH59_126	COG3121	Chaperone
CH59_1260	COG3210	domain, Protein
CH59_1262	COG3210	domain, Protein
CH59_1266	COG2831	hemolysin activation secretion protein
CH59_1267	COG4245	von Willebrand factor, type A
CH59_127	COG3539	Fimbrial protein
CH59_1270	COG4245	von Willebrand factor, type A
CH59_1273	COG3247	response to pH
CH59_1274	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH59_1274	COG1902	pentaerythritol trinitrate reductase activity
CH59_1277	COG1451	nucleotide metabolic process
CH59_1278	COG0673	inositol 2-dehydrogenase activity
CH59_1281	COG1943	Transposase
CH59_1283	COG2721	sulfolactate sulfo-lyase activity
CH59_1284	COG0246	Mannitol dehydrogenase
CH59_1286	COG2271	Major facilitator Superfamily
CH59_1289	COG0586	Pfam SNARE associated Golgi protein
CH59_1292	COG4575	ribosome binding
CH59_1293	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH59_1295	COG2259	Doxx family
CH59_1296	COG0435	Glutathione S-transferase
CH59_1299	COG0494	nUDIX hydrolase
CH59_130	COG0793	Belongs to the peptidase S41A family
CH59_1304	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH59_1305	COG0849	cell division
CH59_1306	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH59_1310	COG0772	Belongs to the SEDS family
CH59_1313	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH59_1314	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH59_1315	COG0768	penicillin binding
CH59_1316	COG3116	cell division
CH59_132	COG1956	GAF domain-containing protein
CH59_1320	COG1609	Transcriptional regulator
CH59_1321	COG1943	Transposase
CH59_1323	COG0028	Belongs to the TPP enzyme family
CH59_1324	COG1022	Amp-dependent synthetase and ligase
CH59_1327	COG1943	Transposase
CH59_1329	COG0473	3-isopropylmalate dehydrogenase activity
CH59_133	COG2995	paraquat-inducible protein a
CH59_1332	COG2814	Major facilitator Superfamily
CH59_1335	COG2814	Major facilitator Superfamily
CH59_1338	COG4143	(ABC) transporter
CH59_1339	COG1178	ABC-type Fe3 transport system permease component
CH59_134	COG3008	intermembrane lipid transfer
CH59_1341	COG0586	Pfam SNARE associated Golgi protein
CH59_1342	COG0417	DNA replication proofreading
CH59_1346	COG3047	cAMP biosynthetic process
CH59_1346	COG2885	chlorophyll binding
CH59_1354	COG3501	Rhs element vgr protein
CH59_1364	COG0564	pseudouridine synthase activity
CH59_1365	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH59_1367	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH59_1368	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CH59_1373	COG1943	Transposase
CH59_1374	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH59_1376	COG2966	Psort location CytoplasmicMembrane, score
CH59_1377	COG1280	lysine exporter protein (LysE YggA)
CH59_1378	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH59_1379	COG0505	Belongs to the CarA family
CH59_138	COG3121	Chaperone
CH59_1381	COG1943	Transposase
CH59_1383	COG1047	Peptidyl-prolyl cis-trans
CH59_1386	COG0196	riboflavin kinase activity
CH59_1388	COG0583	DNA-binding transcription factor activity
CH59_1392	COG1584	GPR1 FUN34 yaaH family protein
CH59_1395	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH59_14	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CH59_1403	COG0745	RESPONSE REGULATOR receiver
CH59_1404	COG3045	CreA protein
CH59_1407	COG2207	Transcriptional regulator
CH59_1407	COG3708	Transcriptional regulator
CH59_1408	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH59_1410	COG0741	lytic transglycosylase activity
CH59_1413	COG2199	diguanylate cyclase activity
CH59_1414	COG2885	chlorophyll binding
CH59_1415	COG0488	(ABC) transporter
CH59_1416	COG0488	(ABC) transporter
CH59_1420	COG0560	Phosphoserine phosphatase
CH59_1421	COG3726	membrane protein affecting hemolysin expression
CH59_1426	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH59_1427	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH59_1428	COG0084	hydrolase, TatD family'
CH59_1429	COG4667	esterase of the alpha-beta hydrolase superfamily
CH59_1431	COG2823	Periplasmic or secreted lipoprotein
CH59_1433	COG0456	acetyltransferase
CH59_1434	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH59_1438	COG3706	GGDEF domain
CH59_1441	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH59_1442	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH59_1445	COG0859	PFAM glycosyl transferase family 9
CH59_1447	COG2390	Transcriptional regulator
CH59_1448	COG2390	Transcriptional regulator
CH59_1456	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH59_1456	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH59_1456	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH59_1457	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH59_1458	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH59_1459	COG2207	Transcriptional regulator
CH59_1460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH59_1462	COG4269	membrane
CH59_1472	COG2963	transposase activity
CH59_1474	COG1401	restriction endodeoxyribonuclease activity
CH59_1478	COG3650	response to hydrogen peroxide
CH59_1479	COG1960	acyl-CoA dehydrogenase activity
CH59_1480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH59_1481	COG0557	exoribonuclease II activity
CH59_1484	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH59_1485	COG0330	HflC and HflK could
CH59_1486	COG0330	HflC and HflK could
CH59_1487	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH59_1491	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH59_1492	COG0802	atpase or kinase
CH59_1493	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH59_1493	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH59_1494	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH59_1497	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH59_15	COG0395	ABC-type sugar transport system, permease component
CH59_1500	COG3264	Mechanosensitive ion channel
CH59_1500	COG1511	domain protein
CH59_1502	COG1053	succinate dehydrogenase
CH59_1503	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH59_1505	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH59_1506	COG1943	Transposase
CH59_1507	COG2076	Multidrug Resistance protein
CH59_151	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH59_1518	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH59_1521	COG3383	formate dehydrogenase (NAD+) activity
CH59_1522	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH59_1523	COG0493	'glutamate synthase
CH59_1523	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH59_1524	COG1309	transcriptional regulator
CH59_1538	COG1454	alcohol dehydrogenase
CH59_154	COG5295	Hep Hag repeat protein
CH59_1540	COG0629	single-stranded DNA binding
CH59_1541	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH59_1542	COG2315	Protein conserved in bacteria
CH59_1543	COG1448	Aminotransferase
CH59_1544	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH59_1545	COG0305	Participates in initiation and elongation during chromosome replication
CH59_1548	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH59_1549	COG0735	belongs to the Fur family
CH59_1551	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH59_1559	COG3121	Chaperone
CH59_156	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH59_157	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH59_1571	COG1358	cellular component organization or biogenesis
CH59_1576	COG3721	Heme iron utilization protein
CH59_1577	COG0702	epimerase
CH59_1578	COG4771	TonB-dependent receptor
CH59_1579	COG3720	iron ion transport
CH59_158	COG0745	RESPONSE REGULATOR receiver
CH59_1580	COG4558	Periplasmic binding protein
CH59_1581	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH59_1583	COG0626	cystathionine gamma-synthase activity
CH59_1584	COG0814	amino acid
CH59_1585	COG0583	DNA-binding transcription factor activity
CH59_1586	COG0425	Belongs to the sulfur carrier protein TusA family
CH59_1587	COG2391	methyltransferase activity
CH59_160	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH59_1609	COG1301	dicarboxylic acid transport
CH59_1611	COG3162	membrane
CH59_1627	COG1175	transmembrane transport
CH59_1628	COG3833	ABC-type maltose transport systems, permease component
CH59_163	COG0840	transmembrane signaling receptor activity
CH59_1631	COG0527	aspartate kinase activity
CH59_1635	COG1414	Transcriptional regulator
CH59_1636	COG1414	Transcriptional regulator
CH59_1638	COG2224	Isocitrate lyase
CH59_1639	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH59_1653	COG0151	Belongs to the GarS family
CH59_1656	COG3068	Protein conserved in bacteria
CH59_1657	COG1515	deoxyribonuclease V activity
CH59_1662	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CH59_1664	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH59_1666	COG2022	thiamine diphosphate biosynthetic process
CH59_1668	COG1943	Transposase
CH59_167	COG2964	Protein conserved in bacteria
CH59_1676	COG0250	Participates in transcription elongation, termination and antitermination
CH59_1677	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH59_1688	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CH59_169	COG0251	oxidation-reduction process
CH59_1694	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CH59_1695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH59_1696	COG1739	Uncharacterized protein family UPF0029
CH59_1697	COG1943	Transposase
CH59_1698	COG1739	Uncharacterized protein family UPF0029
CH59_170	COG2271	Major facilitator Superfamily
CH59_171	COG0835	chemotaxis
CH59_1711	COG0805	protein transport
CH59_1713	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH59_1717	COG1322	Protein conserved in bacteria
CH59_1718	COG0586	Pfam SNARE associated Golgi protein
CH59_1719	COG1966	Carbon starvation protein
CH59_172	COG0643	Histidine kinase
CH59_172	COG2198	Histidine kinase
CH59_1721	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CH59_1722	COG0412	Dienelactone hydrolase
CH59_1725	COG0583	DNA-binding transcription factor activity
CH59_1726	COG0679	Auxin Efflux Carrier
CH59_1727	COG0584	glycerophosphoryl diester phosphodiesterase
CH59_173	COG1360	Flagellar Motor Protein
CH59_1739	COG0410	ABC transporter
CH59_1740	COG0411	ABC transporter
CH59_1741	COG4177	L-phenylalanine transmembrane transporter activity
CH59_1742	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH59_1743	COG0683	leucine binding
CH59_1745	COG1943	Transposase
CH59_1747	COG2177	Part of the ABC transporter FtsEX involved in
CH59_1748	COG2884	Cell division ATP-binding protein ftsE
CH59_1749	COG0552	protein localization to endoplasmic reticulum
CH59_1749	COG0552	protein localization to endoplasmic reticulum
CH59_1750	COG0742	ribosomal rna small subunit methyltransferase
CH59_1751	COG3776	membrane
CH59_1754	COG3714	YhhN family
CH59_1757	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH59_1759	COG0247	lactate metabolic process
CH59_1761	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH59_1762	COG0584	glycerophosphoryl diester phosphodiesterase
CH59_1764	COG0561	phosphatase activity
CH59_1765	COG2267	carboxylic ester hydrolase activity
CH59_1766	COG1280	lysine exporter protein (LysE YggA)
CH59_1767	COG1280	lysine exporter protein (LysE YggA)
CH59_1768	COG0514	ATP-dependent DNA helicase (RecQ)
CH59_1769	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CH59_1770	COG2050	protein possibly involved in aromatic compounds catabolism
CH59_1772	COG0598	Magnesium transport protein CorA
CH59_1773	COG5564	TIM-barrel signal transduction protein
CH59_1774	COG5441	Belongs to the UPF0261 family
CH59_1776	COG0210	DNA helicase
CH59_1777	COG1011	Hydrolase
CH59_1778	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH59_1779	COG3159	Protein conserved in bacteria
CH59_178	COG1285	pathogenesis
CH59_1781	COG5567	small periplasmic lipoprotein
CH59_1783	COG3072	Adenylate cyclase
CH59_1785	COG1587	Uroporphyrinogen-III synthase
CH59_1786	COG2959	enzyme of heme biosynthesis
CH59_1787	COG3071	HemY protein
CH59_1788	COG1943	Transposase
CH59_179	COG0840	transmembrane signaling receptor activity
CH59_1797	COG1113	amino acid transport
CH59_18	COG1609	Transcriptional regulator
CH59_180	COG0840	transmembrane signaling receptor activity
CH59_1801	COG2244	polysaccharide biosynthetic process
CH59_1802	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH59_1803	COG0456	acetyltransferase
CH59_1804	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH59_1805	COG1088	dTDP-glucose 4,6-dehydratase activity
CH59_1806	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH59_1807	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH59_1808	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH59_1809	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH59_1810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH59_1811	COG3118	belongs to the thioredoxin family
CH59_1816	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH59_1818	COG3328	transposase activity
CH59_1819	COG3328	transposase activity
CH59_182	COG1278	Cold shock
CH59_1821	COG3121	Chaperone
CH59_1824	COG3121	Chaperone
CH59_1831	COG0583	DNA-binding transcription factor activity
CH59_184	COG3321	synthase
CH59_184	COG0604	alcohol dehydrogenase
CH59_184	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_1840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH59_1841	COG3978	acetolactate synthase activity
CH59_1844	COG3085	chromosome segregation
CH59_1845	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_1847	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_1848	COG1129	ABC transporter
CH59_1849	COG1879	ABC-type sugar transport system periplasmic component
CH59_186	COG1522	sequence-specific DNA binding
CH59_1863	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH59_1863	COG0678	peroxiredoxin activity
CH59_1864	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH59_1869	COG1629	transport
CH59_1873	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CH59_1881	COG2801	Transposase and inactivated derivatives
CH59_1884	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH59_1885	COG0058	SHG alpha-glucan phosphorylase activity
CH59_1887	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH59_1890	COG3275	phosphorelay sensor kinase activity
CH59_1896	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH59_1897	COG2095	MarC family integral membrane protein
CH59_1901	COG3265	gluconokinase activity
CH59_1902	COG2610	gluconate transmembrane transporter activity
CH59_1903	COG1609	Transcriptional regulator
CH59_1904	COG1741	Belongs to the pirin family
CH59_1906	COG0745	RESPONSE REGULATOR receiver
CH59_1908	COG0191	fructose-bisphosphate aldolase activity
CH59_191	COG1733	regulation of RNA biosynthetic process
CH59_1910	COG1879	ABC-type sugar transport system periplasmic component
CH59_1911	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_1914	COG2081	HI0933 family
CH59_1915	COG0306	phosphate transporter
CH59_1916	COG1943	Transposase
CH59_1917	COG1943	Transposase
CH59_1919	COG0589	response to stress
CH59_192	COG0702	epimerase
CH59_1923	COG0339	signal peptide processing
CH59_1924	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH59_1925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH59_1926	COG3835	regulator
CH59_1927	COG2610	gluconate transmembrane transporter activity
CH59_1928	COG1929	Belongs to the glycerate kinase type-1 family
CH59_193	COG0840	transmembrane signaling receptor activity
CH59_1933	COG1295	ribonuclease BN
CH59_1934	COG2982	Protein involved in outer membrane biogenesis
CH59_1935	COG2134	cdp-diacylglycerol pyrophosphatase
CH59_1936	COG2200	EAL domain
CH59_1937	COG1942	4-Oxalocrotonate Tautomerase
CH59_1938	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH59_1939	COG0612	Peptidase, M16
CH59_1944	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH59_1945	COG2199	diguanylate cyclase activity
CH59_1945	COG2200	EAL domain
CH59_1946	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CH59_1947	COG4608	Belongs to the ABC transporter superfamily
CH59_1948	COG0444	Belongs to the ABC transporter superfamily
CH59_1949	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH59_1950	COG0601	transmembrane transport
CH59_1951	COG0747	negative chemotaxis
CH59_1953	COG2831	hemolysin activation secretion protein
CH59_1957	COG2271	Major facilitator Superfamily
CH59_196	COG0538	isocitrate dehydrogenase activity
CH59_1963	COG3851	Histidine kinase
CH59_1964	COG2197	response regulator
CH59_1965	COG2194	sulfuric ester hydrolase activity
CH59_1968	COG2986	histidine ammonia-lyase
CH59_197	COG1187	pseudouridine synthase activity
CH59_1971	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH59_1974	COG4607	ABC-type enterochelin transport system periplasmic component
CH59_1976	COG4605	iron ion homeostasis
CH59_1978	COG4604	ABC transporter, ATP-binding protein
CH59_1985	COG0582	viral genome integration into host DNA
CH59_1987	COG2207	Transcriptional regulator
CH59_1987	COG1609	Transcriptional regulator
CH59_1988	COG4214	carbohydrate transport
CH59_1990	COG4213	ABC transporter substrate-binding protein
CH59_1992	COG1070	Carbohydrate kinase
CH59_1994	COG3121	Chaperone
CH59_1995	COG3188	usher protein
CH59_1996	COG3188	usher protein
CH59_1998	COG3274	enterobacterial common antigen metabolic process
CH59_20	COG3842	ATPase activity
CH59_2000	COG2801	Transposase and inactivated derivatives
CH59_201	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH59_2011	COG2864	formate dehydrogenase
CH59_2012	COG0437	4 iron, 4 sulfur cluster binding
CH59_2013	COG0243	molybdopterin cofactor binding
CH59_2013	COG3383	formate dehydrogenase (NAD+) activity
CH59_2014	COG0243	molybdopterin cofactor binding
CH59_2014	COG3383	formate dehydrogenase (NAD+) activity
CH59_2016	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH59_2017	COG1943	Transposase
CH59_2024	COG3722	fumarate hydratase activity
CH59_2026	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH59_2026	COG2213	PTS system mannitol-specific
CH59_203	COG0745	RESPONSE REGULATOR receiver
CH59_2031	COG2818	Glycosylase
CH59_2033	COG2885	chlorophyll binding
CH59_2036	COG0366	Alpha amylase catalytic
CH59_2038	COG3977	Valine--pyruvate aminotransferase
CH59_2042	COG5645	(Lipo)protein
CH59_2043	COG0823	Involved in the tonB-independent uptake of proteins
CH59_2044	COG0823	Involved in the tonB-independent uptake of proteins
CH59_2045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH59_2046	COG2423	ornithine cyclodeaminase activity
CH59_2049	COG2801	Transposase and inactivated derivatives
CH59_205	COG2850	peptidyl-arginine hydroxylation
CH59_2050	COG0561	phosphatase activity
CH59_2051	COG0187	DNA topoisomerase II activity
CH59_2052	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH59_2053	COG0592	DNA-directed DNA polymerase activity
CH59_2056	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH59_2059	COG0706	membrane insertase activity
CH59_2064	COG2252	PERMEase
CH59_2065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH59_2066	COG0765	amino acid transport
CH59_2067	COG0765	amino acid transport
CH59_2068	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH59_207	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH59_2070	COG0704	Plays a role in the regulation of phosphate uptake
CH59_2072	COG0581	inorganic phosphate transmembrane transporter activity
CH59_2073	COG0573	inorganic phosphate transmembrane transporter activity
CH59_2074	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH59_2075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CH59_2085	COG3312	ion transport
CH59_2088	COG0716	FMN binding
CH59_2089	COG1522	sequence-specific DNA binding
CH59_209	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH59_2098	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH59_2099	COG0477	Major facilitator Superfamily
CH59_2101	COG2186	Transcriptional regulator
CH59_2106	COG3328	transposase activity
CH59_2107	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH59_2109	COG3084	Protein conserved in bacteria
CH59_211	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH59_2110	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH59_2111	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH59_2112	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH59_2112	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH59_2113	COG1943	Transposase
CH59_2116	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH59_2118	COG3852	Histidine kinase
CH59_2119	COG0174	glutamine synthetase
CH59_212	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH59_2121	COG1011	Hydrolase
CH59_2122	COG1295	ribonuclease BN
CH59_2126	COG0456	acetyltransferase
CH59_2127	COG2982	Protein involved in outer membrane biogenesis
CH59_2128	COG2233	PERMEase
CH59_2129	COG0786	glutamate:sodium symporter activity
CH59_213	COG3134	Outer membrane lipoprotein
CH59_2130	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH59_2131	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH59_2132	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH59_2135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH59_2136	COG2860	membrane
CH59_2137	COG1561	YicC-like family, N-terminal region
CH59_2142	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH59_2145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH59_2149	COG1519	Transferase
CH59_2150	COG0859	PFAM glycosyl transferase family 9
CH59_2151	COG0859	PFAM glycosyl transferase family 9
CH59_2153	COG0156	8-amino-7-oxononanoate synthase activity
CH59_2155	COG2861	carbohydrate metabolic process
CH59_2156	COG2861	carbohydrate metabolic process
CH59_2157	COG4942	peptidase
CH59_2159	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH59_216	COG3328	transposase activity
CH59_2160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH59_2163	COG1045	serine acetyltransferase
CH59_2164	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH59_2165	COG2169	Transcriptional regulator
CH59_2165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH59_2166	COG2205	protein histidine kinase activity
CH59_2167	COG0745	RESPONSE REGULATOR receiver
CH59_2168	COG3678	ATP-independent chaperone mediated protein folding
CH59_2173	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH59_2175	COG0471	metal ion transport
CH59_2176	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CH59_2177	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CH59_2178	COG0583	DNA-binding transcription factor activity
CH59_2181	COG3152	Membrane
CH59_2183	COG1494	fructose-1,6-bisphosphatase
CH59_2184	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH59_2185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH59_2187	COG1943	Transposase
CH59_219	COG1252	NADH dehydrogenase
CH59_2196	COG1575	Belongs to the MenA family. Type 1 subfamily
CH59_2199	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH59_22	COG3210	domain, Protein
CH59_2200	COG1609	Transcriptional regulator
CH59_2202	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH59_2204	COG4682	membrane
CH59_2206	COG0626	cystathionine gamma-synthase activity
CH59_2207	COG0626	cystathionine gamma-synthase activity
CH59_2208	COG0460	homoserine dehydrogenase
CH59_2208	COG0527	aspartate kinase activity
CH59_221	COG1472	Belongs to the glycosyl hydrolase 3 family
CH59_2210	COG2801	Transposase and inactivated derivatives
CH59_2212	COG1349	DNA-binding transcription factor activity
CH59_2214	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH59_2216	COG0058	SHG alpha-glucan phosphorylase activity
CH59_2217	COG0058	SHG alpha-glucan phosphorylase activity
CH59_2218	COG1640	4-alpha-glucanotransferase
CH59_2225	COG1918	ferrous iron import across plasma membrane
CH59_2226	COG2183	response to ionizing radiation
CH59_2227	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH59_2228	COG0745	RESPONSE REGULATOR receiver
CH59_2232	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH59_2233	COG1011	Hydrolase
CH59_2236	COG0494	nUDIX hydrolase
CH59_2237	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH59_224	COG5633	Lipoprotein
CH59_2242	COG4796	Type ii and iii secretion system protein
CH59_2247	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH59_2248	COG0546	phosphoglycolate phosphatase activity
CH59_2249	COG0180	Tryptophanyl-tRNA synthetase
CH59_225	COG0537	adenosine 5'-monophosphoramidase activity
CH59_2252	COG2146	nitrite reductase [NAD(P)H] activity
CH59_2253	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH59_2254	COG0402	S-adenosylhomocysteine deaminase activity
CH59_226	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH59_2261	COG1486	melibiose metabolic process
CH59_2262	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH59_2263	COG0433	COG0433 Predicted ATPase
CH59_2266	COG1289	transmembrane transporter activity
CH59_2268	COG1765	OsmC-like protein
CH59_227	COG1943	Transposase
CH59_2270	COG3954	Phosphoribulokinase
CH59_2272	COG0429	hydrolase of the alpha beta-hydrolase fold
CH59_2274	COG4521	taurine ABC transporter
CH59_2276	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH59_2277	COG2175	clavaminate synthase activity
CH59_2279	COG1216	Glycosyl transferase, family 2
CH59_228	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH59_228	COG1263	PTS System
CH59_2280	COG0488	(ABC) transporter
CH59_2281	COG0488	(ABC) transporter
CH59_2284	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH59_2285	COG1047	Peptidyl-prolyl cis-trans
CH59_2287	COG0545	Peptidyl-prolyl cis-trans isomerase
CH59_2288	COG2964	Protein conserved in bacteria
CH59_229	COG0084	hydrolase, TatD family'
CH59_2292	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH59_2293	COG0049	tRNA binding
CH59_2296	COG1943	Transposase
CH59_2299	COG0051	transcription antitermination factor activity, RNA binding
CH59_230	COG0470	DNA polymerase III
CH59_2304	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH59_2306	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CH59_2307	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH59_2309	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH59_2310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH59_2318	COG1841	ribosomal large subunit assembly
CH59_232	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH59_2320	COG0201	protein transport
CH59_2321	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH59_2324	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH59_2327	COG0789	Transcriptional regulator
CH59_2328	COG3036	rescue of stalled ribosome
CH59_233	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH59_2330	COG0569	domain protein
CH59_2334	COG0758	DNA mediated transformation
CH59_2336	COG0551	DNA topoisomerase type I activity
CH59_2339	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH59_234	COG1943	Transposase
CH59_2343	COG2801	Transposase and inactivated derivatives
CH59_235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH59_2359	COG3501	Rhs element vgr protein
CH59_2362	COG3209	COG3209 Rhs family protein
CH59_2368	COG3501	Rhs element vgr protein
CH59_237	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_2370	COG3209	COG3209 Rhs family protein
CH59_2373	COG0673	inositol 2-dehydrogenase activity
CH59_2374	COG2207	Transcriptional regulator
CH59_2374	COG1917	Cupin 2, conserved barrel domain protein
CH59_2375	COG1869	D-ribose catabolic process
CH59_2376	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH59_2378	COG0431	NADPH-dependent FMN reductase
CH59_2379	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH59_2381	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH59_2383	COG3077	Addiction module antitoxin, RelB DinJ family
CH59_2384	COG2252	PERMEase
CH59_2385	COG0025	NhaP-type Na H and K H
CH59_2387	COG1560	Kdo2-lipid A biosynthetic process
CH59_2389	COG1129	ABC transporter
CH59_2390	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_2392	COG1069	ribulokinase activity
CH59_2394	COG0625	glutathione transferase activity
CH59_2397	COG1943	Transposase
CH59_2398	COG1278	Cold shock
CH59_2399	COG1278	Cold shock
CH59_2400	COG3133	Outer membrane lipoprotein
CH59_2401	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH59_2403	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH59_2407	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH59_2408	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH59_241	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH59_2410	COG4145	pantothenate transmembrane transporter activity
CH59_2411	COG3924	membrane
CH59_2413	COG0439	Biotin carboxylase
CH59_2414	COG0511	ligase activity, forming carbon-carbon bonds
CH59_2417	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CH59_2418	COG0604	alcohol dehydrogenase
CH59_2419	COG2199	diguanylate cyclase activity
CH59_2419	COG2200	EAL domain
CH59_242	COG1399	metal-binding, possibly nucleic acid-binding protein
CH59_2420	COG1077	Cell shape determining protein MreB Mrl
CH59_2421	COG1792	Involved in formation and maintenance of cell shape
CH59_2422	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH59_2424	COG1530	ribonuclease E activity
CH59_2425	COG3164	Protein of unknown function
CH59_2426	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH59_2427	COG0312	modulator of DNA gyrase
CH59_2439	COG0583	DNA-binding transcription factor activity
CH59_244	COG1943	Transposase
CH59_2443	COG1012	belongs to the aldehyde dehydrogenase family
CH59_2446	COG2732	(Barnase) inhibitor
CH59_2448	COG0312	modulator of DNA gyrase
CH59_245	COG0564	pseudouridine synthase activity
CH59_2450	COG3783	Cytochrome b(562)
CH59_2451	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH59_2452	COG0366	Alpha amylase catalytic
CH59_2453	COG1263	PTS System
CH59_2453	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH59_2454	COG1609	Transcriptional regulator
CH59_246	COG1530	ribonuclease E activity
CH59_2461	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH59_2463	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH59_2465	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH59_2466	COG1137	ATPase activity
CH59_2467	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH59_2468	COG3117	lipopolysaccharide transmembrane transporter activity
CH59_2469	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH59_247	COG1388	LysM domain
CH59_247	COG1470	cell adhesion involved in biofilm formation
CH59_2470	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH59_2470	COG0517	IMP dehydrogenase activity
CH59_2471	COG0530	calcium, potassium:sodium antiporter activity
CH59_2472	COG1127	ABC transporter
CH59_2473	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH59_2474	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH59_2475	COG2854	intermembrane phospholipid transfer
CH59_2476	COG3113	response to antibiotic
CH59_2477	COG5007	Belongs to the BolA IbaG family
CH59_2479	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH59_248	COG3328	transposase activity
CH59_2480	COG1943	Transposase
CH59_2481	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH59_2482	COG3105	Protein conserved in bacteria
CH59_2483	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH59_2486	COG0625	glutathione transferase activity
CH59_2487	COG2969	positive regulation of protein catabolic process
CH59_2489	COG0493	'glutamate synthase
CH59_249	COG2271	Major facilitator Superfamily
CH59_2490	COG0070	glutamate synthase
CH59_2490	COG0069	glutamate synthase activity
CH59_2490	COG0067	glutamate synthase
CH59_2491	COG1242	4 iron, 4 sulfur cluster binding
CH59_2492	COG5002	protein histidine kinase activity
CH59_2492	COG2198	Histidine kinase
CH59_2492	COG0784	Response regulator, receiver
CH59_2493	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH59_2495	COG2823	Periplasmic or secreted lipoprotein
CH59_2499	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH59_25	COG3210	domain, Protein
CH59_250	COG3011	Protein conserved in bacteria
CH59_2500	COG1741	Belongs to the pirin family
CH59_2501	COG0583	DNA-binding transcription factor activity
CH59_2502	COG0435	Glutathione S-transferase
CH59_2505	COG1073	alpha beta
CH59_2507	COG0360	Binds together with S18 to 16S ribosomal RNA
CH59_2508	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH59_251	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_2510	COG1943	Transposase
CH59_2512	COG3061	Opacity-associated protein A
CH59_2513	COG0545	Peptidyl-prolyl cis-trans isomerase
CH59_2515	COG0737	Belongs to the 5'-nucleotidase family
CH59_2517	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH59_2519	COG1253	flavin adenine dinucleotide binding
CH59_2521	COG0729	surface antigen
CH59_2522	COG2911	Protein conserved in bacteria
CH59_2523	COG2105	PFAM AIG2 family protein
CH59_2524	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH59_2526	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH59_253	COG4948	Mandelate Racemase Muconate Lactonizing
CH59_2530	COG3423	Transcriptional regulator
CH59_2532	COG0142	geranyltranstransferase activity
CH59_2535	COG0697	spore germination
CH59_2537	COG0642	Histidine kinase
CH59_2538	COG0745	RESPONSE REGULATOR receiver
CH59_2539	COG2027	D-alanyl-D-alanine carboxypeptidase
CH59_2540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH59_2541	COG1534	Rna-binding protein
CH59_2543	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CH59_2544	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH59_2546	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH59_2550	COG0195	Participates in both transcription termination and antitermination
CH59_2556	COG2801	Transposase and inactivated derivatives
CH59_2559	COG0513	Belongs to the DEAD box helicase family
CH59_2562	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH59_2565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH59_257	COG0534	Mate efflux family protein
CH59_2570	COG3153	acetyltransferase
CH59_2574	COG1653	transport
CH59_2576	COG0395	ABC-type sugar transport system, permease component
CH59_2577	COG3842	ATPase activity
CH59_2580	COG0702	epimerase
CH59_2581	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CH59_2582	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CH59_2583	COG3454	Phosphonate metabolism
CH59_2584	COG4778	phosphonate C-P lyase system protein PhnL
CH59_2585	COG4107	phosphonate C-P lyase system protein PhnK
CH59_2586	COG3627	carbon phosphorus lyase activity
CH59_2587	COG3626	phosphonate metabolism
CH59_2588	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CH59_2589	COG3624	Phosphonate C-P lyase system protein PhnG
CH59_2590	COG2188	Transcriptional regulator
CH59_2594	COG4608	Belongs to the ABC transporter superfamily
CH59_2595	COG0444	Belongs to the ABC transporter superfamily
CH59_2596	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH59_2597	COG0601	transmembrane transport
CH59_2600	COG2731	YhcH YjgK YiaL family protein
CH59_2601	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CH59_2602	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH59_2604	COG0525	valine-tRNA ligase activity
CH59_2605	COG2927	DNA polymerase III (CHI subunit)
CH59_2607	COG0795	lipopolysaccharide-transporting ATPase activity
CH59_2608	COG0795	lipopolysaccharide-transporting ATPase activity
CH59_261	COG3122	Protein conserved in bacteria
CH59_2610	COG0582	viral genome integration into host DNA
CH59_2616	COG1943	Transposase
CH59_2619	COG0237	dephospho-CoA kinase activity
CH59_2621	COG1459	type II secretion system
CH59_2622	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH59_2623	COG4969	Belongs to the N-Me-Phe pilin family
CH59_2625	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH59_2626	COG3725	Membrane protein required for beta-lactamase induction
CH59_2627	COG1113	amino acid transport
CH59_2628	COG2186	Transcriptional regulator
CH59_2629	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH59_2630	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH59_2631	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH59_2632	COG1943	Transposase
CH59_2633	COG1049	propionate catabolic process, 2-methylcitrate cycle
CH59_2635	COG0697	spore germination
CH59_2639	COG2132	Multicopper oxidase
CH59_2640	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH59_2641	COG0288	reversible hydration of carbon dioxide
CH59_2642	COG1131	(ABC) transporter
CH59_2643	COG0842	Transport permease protein
CH59_2644	COG0726	polysaccharide deacetylase
CH59_2648	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH59_2649	COG0617	tRNA 3'-terminal CCA addition
CH59_2650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH59_2651	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH59_2653	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CH59_2654	COG1643	Atp-dependent helicase
CH59_2655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH59_2656	COG1120	ATPase activity
CH59_2657	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH59_2658	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH59_266	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH59_2662	COG2860	membrane
CH59_2664	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH59_2666	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH59_2667	COG3850	Histidine kinase
CH59_2667	COG4999	Histidine kinase
CH59_2667	COG3437	response regulator, receiver
CH59_2667	COG2205	protein histidine kinase activity
CH59_2668	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH59_2669	COG3956	TIGRFAM MazG family protein
CH59_2673	COG0602	queuosine metabolic process
CH59_2674	COG0720	synthase
CH59_2685	COG0529	Catalyzes the synthesis of activated sulfate
CH59_2688	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CH59_2693	COG1388	LysM domain
CH59_2693	COG4942	peptidase
CH59_2694	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH59_2695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH59_2696	COG0698	ribose 5-phosphate isomerase
CH59_2697	COG1063	alcohol dehydrogenase
CH59_2698	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_2699	COG2376	Dihydroxyacetone kinase
CH59_2702	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH59_2706	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH59_2707	COG1858	cytochrome C peroxidase
CH59_2709	COG4771	TonB-dependent receptor
CH59_271	COG2223	nitrite transmembrane transporter activity
CH59_2712	COG0024	Methionine aminopeptidase
CH59_2714	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH59_2714	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH59_2715	COG1070	Carbohydrate kinase
CH59_2716	COG3623	hexulose-6-phosphate isomerase
CH59_2717	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_2718	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_2719	COG1129	ABC transporter
CH59_2720	COG1943	Transposase
CH59_2722	COG1349	DNA-binding transcription factor activity
CH59_2723	COG0235	Class ii aldolase
CH59_2724	COG0243	molybdopterin cofactor binding
CH59_2725	COG0437	4 iron, 4 sulfur cluster binding
CH59_2726	COG3302	dmso reductase anchor subunit
CH59_2727	COG3381	protein complex oligomerization
CH59_2728	COG3038	cytochrome b561
CH59_2729	COG3783	Cytochrome b(562)
CH59_273	COG3328	transposase activity
CH59_2733	COG1129	ABC transporter
CH59_2734	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_2735	COG3959	Transketolase, thiamine diphosphate binding domain
CH59_2736	COG3958	Transketolase
CH59_2737	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH59_2744	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH59_2745	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH59_2750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH59_2751	COG1238	metal cluster binding
CH59_2752	COG2918	glutathione biosynthetic process
CH59_2754	COG1943	Transposase
CH59_2755	COG1943	Transposase
CH59_2756	COG4536	flavin adenine dinucleotide binding
CH59_2757	COG4137	Cytochrome C assembly protein
CH59_2758	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH59_276	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH59_2763	COG1943	Transposase
CH59_2764	COG3137	Salt-induced outer membrane protein
CH59_2765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH59_2766	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH59_2767	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH59_2768	COG3279	Response regulator of the LytR AlgR family
CH59_2769	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH59_277	COG3328	transposase activity
CH59_2770	COG0287	Prephenate dehydrogenase
CH59_2770	COG1605	Chorismate mutase
CH59_2771	COG1605	Chorismate mutase
CH59_2771	COG0077	Prephenate dehydratase
CH59_2776	COG0077	Prephenate dehydratase
CH59_2776	COG1605	Chorismate mutase
CH59_2777	COG1943	Transposase
CH59_2778	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH59_2779	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH59_2780	COG0564	pseudouridine synthase activity
CH59_2782	COG0542	response to heat
CH59_2789	COG5544	Lipoprotein
CH59_2790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH59_2791	COG1042	CoA-binding domain protein
CH59_2791	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH59_2791	COG0045	succinate-CoA ligase (ADP-forming) activity
CH59_2793	COG3118	belongs to the thioredoxin family
CH59_2794	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH59_2795	COG2814	Major facilitator Superfamily
CH59_2796	COG1566	PFAM secretion protein HlyD family protein
CH59_2797	COG1846	Transcriptional regulator
CH59_2799	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH59_28	COG3210	domain, Protein
CH59_280	COG2925	Exonuclease
CH59_2800	COG2814	Major facilitator Superfamily
CH59_2809	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH59_281	COG0531	amino acid
CH59_2814	COG1940	carbohydrate kinase activity
CH59_2819	COG2226	methyltransferase
CH59_283	COG0371	Dehydrogenase
CH59_2830	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH59_2834	COG1477	protein flavinylation
CH59_2838	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH59_2839	COG1805	sodium ion transport
CH59_284	COG1129	ABC transporter
CH59_2840	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH59_2841	COG0121	glutamine amidotransferase
CH59_2842	COG3034	peptidoglycan biosynthetic process
CH59_2844	COG1960	acyl-CoA dehydrogenase activity
CH59_2846	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH59_285	COG1129	ABC transporter
CH59_2850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH59_2853	COG0419	ATPase involved in DNA repair
CH59_2854	COG0420	3'-5' exonuclease activity
CH59_2855	COG0745	RESPONSE REGULATOR receiver
CH59_2856	COG5002	protein histidine kinase activity
CH59_2858	COG1114	Component of the transport system for branched-chain amino acids
CH59_286	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_2860	COG1943	Transposase
CH59_2861	COG0366	Alpha amylase catalytic
CH59_2865	COG1943	Transposase
CH59_2866	COG0450	alkyl hydroperoxide reductase
CH59_2867	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH59_2868	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CH59_2870	COG1862	Preprotein translocase
CH59_2871	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH59_2872	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH59_2873	COG1943	Transposase
CH59_2877	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH59_2877	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH59_288	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH59_2880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH59_2881	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH59_2882	COG1943	Transposase
CH59_2884	COG0142	geranyltranstransferase activity
CH59_2887	COG0693	protein deglycase activity
CH59_2888	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH59_2890	COG2814	Major facilitator Superfamily
CH59_2892	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH59_2893	COG1845	cytochrome c oxidase, subunit III
CH59_2894	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH59_2895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH59_2897	COG2223	nitrite transmembrane transporter activity
CH59_2898	COG3056	Lipoprotein
CH59_2899	COG0271	Belongs to the BolA IbaG family
CH59_29	COG2831	hemolysin activation secretion protein
CH59_290	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CH59_2904	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH59_2905	COG0776	regulation of translation
CH59_2907	COG1943	Transposase
CH59_2908	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH59_2909	COG1555	photosystem II stabilization
CH59_2910	COG0824	Thioesterase
CH59_2912	COG4533	DNA binding
CH59_2915	COG1522	sequence-specific DNA binding
CH59_2916	COG1132	(ABC) transporter
CH59_2917	COG1132	(ABC) transporter
CH59_2918	COG0347	Belongs to the P(II) protein family
CH59_292	COG0131	Imidazoleglycerol-phosphate dehydratase
CH59_292	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH59_2924	COG0004	ammonium transporteR
CH59_2925	COG1946	Acyl-CoA thioesterase
CH59_2926	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH59_2927	COG3695	enzyme binding
CH59_293	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CH59_2931	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH59_2933	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH59_2934	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH59_2935	COG1309	transcriptional regulator
CH59_2936	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH59_2937	COG1196	nuclear chromosome segregation
CH59_2937	COG3264	Mechanosensitive ion channel
CH59_2939	COG2832	Protein of unknown function (DUF454)
CH59_2943	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CH59_2949	COG0543	2 iron, 2 sulfur cluster binding
CH59_2949	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH59_2953	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH59_296	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH59_296	COG0140	phosphoribosyl-ATP diphosphatase activity
CH59_2962	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH59_2963	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH59_2969	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH59_2970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH59_2971	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH59_2971	COG4651	solute:proton antiporter activity
CH59_2972	COG2223	nitrite transmembrane transporter activity
CH59_2973	COG0737	Belongs to the 5'-nucleotidase family
CH59_2974	COG0737	Belongs to the 5'-nucleotidase family
CH59_2975	COG0737	Belongs to the 5'-nucleotidase family
CH59_2978	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH59_2979	COG3735	TraB family
CH59_298	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH59_2980	COG2217	Heavy metal translocating P-type atpase
CH59_2981	COG0789	Transcriptional regulator
CH59_2982	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH59_2983	COG0330	HflC and HflK could
CH59_2984	COG3118	belongs to the thioredoxin family
CH59_2985	COG0300	oxidoreductase activity
CH59_2986	COG2755	lipolytic protein G-D-S-L family
CH59_2987	COG4181	ATPase activity
CH59_2988	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH59_2989	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH59_299	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH59_2990	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH59_2992	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH59_2995	COG1943	Transposase
CH59_2996	COG1943	Transposase
CH59_2998	COG1393	Belongs to the ArsC family
CH59_2999	COG4783	chaperone-mediated protein folding
CH59_3	COG0667	Aldo Keto reductase
CH59_30	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH59_3000	COG0628	permease
CH59_3003	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH59_3004	COG2716	regulation of RNA biosynthetic process
CH59_3006	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH59_3007	COG1943	Transposase
CH59_3009	COG2321	neutral zinc metallopeptidase
CH59_3013	COG1876	peptidase activity
CH59_3015	COG1393	Belongs to the ArsC family
CH59_302	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH59_3020	COG1840	ABC-type Fe3 transport system, periplasmic component
CH59_3021	COG1175	transmembrane transport
CH59_3022	COG3842	ATPase activity
CH59_3023	COG3119	arylsulfatase activity
CH59_3024	COG0641	radical SAM
CH59_3025	COG1988	membrane-bound metal-dependent
CH59_3027	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH59_3029	COG2197	response regulator
CH59_303	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH59_3030	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH59_3030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH59_3031	COG3062	negative regulation of establishment of protein localization
CH59_3033	COG3043	anaerobic respiration
CH59_3034	COG3005	denitrification pathway
CH59_304	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH59_3043	COG3111	PFAM Bacterial OB fold (BOF) protein
CH59_3045	COG2837	iron assimilation
CH59_3046	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH59_3048	COG4886	Leucine-rich repeat (LRR) protein
CH59_305	COG1120	ATPase activity
CH59_3050	COG2731	YhcH YjgK YiaL family protein
CH59_3051	COG1737	Transcriptional regulator
CH59_3053	COG4150	thiosulfate binding
CH59_3054	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH59_3055	COG4208	sulfate ABC transporter
CH59_3056	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CH59_3059	COG0745	RESPONSE REGULATOR receiver
CH59_3060	COG5002	protein histidine kinase activity
CH59_3060	COG3850	Histidine kinase
CH59_3062	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH59_3064	COG0006	proline dipeptidase activity
CH59_3066	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH59_3069	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH59_3070	COG0745	RESPONSE REGULATOR receiver
CH59_3071	COG2205	protein histidine kinase activity
CH59_3073	COG1943	Transposase
CH59_3074	COG2190	(PTS) system
CH59_3076	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH59_3077	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CH59_3078	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CH59_308	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CH59_3081	COG3530	Putative quorum-sensing-regulated virulence factor
CH59_3087	COG1943	Transposase
CH59_309	COG0076	glutamate decarboxylase activity
CH59_3093	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH59_3096	COG0667	Aldo Keto reductase
CH59_31	COG4638	Rieske (2fe-2S)
CH59_310	COG4114	ferric iron reductase
CH59_3101	COG0436	Aminotransferase
CH59_3102	COG3038	cytochrome b561
CH59_3108	COG3381	protein complex oligomerization
CH59_3109	COG3302	dmso reductase anchor subunit
CH59_311	COG1253	flavin adenine dinucleotide binding
CH59_3110	COG0437	4 iron, 4 sulfur cluster binding
CH59_3111	COG0243	molybdopterin cofactor binding
CH59_3118	COG2951	lytic endotransglycosylase activity
CH59_312	COG2982	Protein involved in outer membrane biogenesis
CH59_3130	COG3121	Chaperone
CH59_3131	COG3188	usher protein
CH59_3132	COG3328	transposase activity
CH59_3133	COG3188	usher protein
CH59_3143	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH59_3145	COG1943	Transposase
CH59_3146	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH59_3147	COG1737	Transcriptional regulator
CH59_3149	COG0560	Phosphoserine phosphatase
CH59_315	COG0489	protein tyrosine kinase activity
CH59_3150	COG0590	tRNA wobble adenosine to inosine editing
CH59_3156	COG1943	Transposase
CH59_3157	COG1943	Transposase
CH59_3158	COG2205	protein histidine kinase activity
CH59_3159	COG3170	Tfp pilus assembly protein FimV
CH59_3160	COG2204	response regulator
CH59_3161	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH59_3161	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH59_3162	COG0347	Belongs to the P(II) protein family
CH59_3165	COG1017	nitric oxide dioxygenase activity
CH59_3165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH59_3168	COG3711	transcriptional antiterminator
CH59_3169	COG2814	Major facilitator Superfamily
CH59_317	COG1943	Transposase
CH59_3170	COG3683	transport system, periplasmic component
CH59_3171	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH59_3172	COG1943	Transposase
CH59_3173	COG0483	inositol monophosphate 1-phosphatase activity
CH59_3176	COG1104	cysteine desulfurase activity
CH59_3177	COG0822	iron-sulfur transferase activity
CH59_3180	COG0443	Heat shock 70 kDa protein
CH59_3181	COG0633	Ferredoxin
CH59_3182	COG2975	iron-sulfur cluster assembly
CH59_3186	COG3468	outer membrane autotransporter barrel domain protein
CH59_3187	COG3468	outer membrane autotransporter barrel domain protein
CH59_3195	COG2976	Protein conserved in bacteria
CH59_3196	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH59_3199	COG1645	bacterial-type flagellum-dependent swarming motility
CH59_32	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CH59_3201	COG0517	IMP dehydrogenase activity
CH59_3201	COG0516	GMP reductase activity
CH59_3203	COG1943	Transposase
CH59_3210	COG3328	transposase activity
CH59_3213	COG0351	phosphomethylpyrimidine kinase
CH59_3219	COG3422	double-strand break repair
CH59_3220	COG0745	RESPONSE REGULATOR receiver
CH59_3221	COG2205	protein histidine kinase activity
CH59_3226	COG3842	ATPase activity
CH59_3228	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CH59_323	COG2814	Major facilitator Superfamily
CH59_3230	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH59_3231	COG1177	transmembrane transport
CH59_3232	COG0443	Heat shock 70 kDa protein
CH59_3233	COG2239	Acts as a magnesium transporter
CH59_3234	COG0248	Ppx GppA phosphatase
CH59_3235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH59_3237	COG0581	inorganic phosphate transmembrane transporter activity
CH59_3241	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH59_3242	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH59_3245	COG1943	Transposase
CH59_3246	COG2501	S4 domain
CH59_325	COG1346	cytolysis
CH59_3254	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH59_3255	COG4589	Belongs to the CDS family
CH59_3257	COG2267	carboxylic ester hydrolase activity
CH59_3258	COG2453	phosphatase
CH59_3258	COG0671	phosphoesterase, PA-phosphatase related
CH59_3266	COG0395	ABC-type sugar transport system, permease component
CH59_3267	COG1175	transmembrane transport
CH59_3269	COG0673	inositol 2-dehydrogenase activity
CH59_3276	COG3328	transposase activity
CH59_3277	COG3328	transposase activity
CH59_328	COG2949	membrane
CH59_329	COG4211	Belongs to the binding-protein-dependent transport system permease family
CH59_33	COG0473	3-isopropylmalate dehydrogenase activity
CH59_3301	COG2197	response regulator
CH59_3303	COG3136	membrane protein required for alginate biosynthesis
CH59_3307	COG1113	amino acid transport
CH59_3310	COG2837	iron assimilation
CH59_3315	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH59_3315	COG0506	proline dehydrogenase activity
CH59_3315	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH59_332	COG2311	Membrane
CH59_3321	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH59_3323	COG1191	sigma factor activity
CH59_3329	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CH59_3330	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH59_3331	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CH59_3334	COG1677	Flagellar hook-basal body complex protein FliE
CH59_3336	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH59_3338	COG1157	protein secretion by the type III secretion system
CH59_3339	COG2882	bacterial-type flagellum organization
CH59_334	COG0477	Major facilitator Superfamily
CH59_3341	COG1580	Controls the rotational direction of flagella during chemotaxis
CH59_3346	COG1987	bacterial-type flagellum assembly
CH59_335	COG0583	DNA-binding transcription factor activity
CH59_3350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH59_3351	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_3352	COG1129	ABC transporter
CH59_3354	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_3355	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_3355	COG3347	Dehydrogenase
CH59_3356	COG2390	Transcriptional regulator
CH59_3358	COG1256	bacterial-type flagellum assembly
CH59_3362	COG4786	Flagellar basal body rod
CH59_3364	COG1749	Flagellar hook protein flgE
CH59_3365	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH59_3366	COG1558	bacterial-type flagellum-dependent cell motility
CH59_3367	COG1815	bacterial-type flagellum-dependent cell motility
CH59_3369	COG2747	anti-sigma28 factor FlgM
CH59_3370	COG3418	PFAM FlgN family protein
CH59_3372	COG1943	Transposase
CH59_3375	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH59_3376	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH59_3383	COG2372	response to copper ion
CH59_3384	COG1528	Iron-storage protein
CH59_3387	COG1770	oligopeptidase
CH59_3390	COG3141	response to X-ray
CH59_3391	COG0513	Belongs to the DEAD box helicase family
CH59_3396	COG1760	l-serine dehydratase
CH59_3397	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CH59_3398	COG2368	4-hydroxyphenylacetate
CH59_34	COG0583	DNA-binding transcription factor activity
CH59_3401	COG3971	2-oxopent-4-enoate hydratase activity
CH59_3403	COG3384	dioxygenase
CH59_3404	COG1012	belongs to the aldehyde dehydrogenase family
CH59_3407	COG1846	Transcriptional regulator
CH59_3408	COG1253	flavin adenine dinucleotide binding
CH59_3409	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH59_3409	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH59_341	COG1136	(ABC) transporter
CH59_3410	COG3715	PTS system
CH59_3411	COG3716	PTS system mannose fructose sorbose family IID component
CH59_3415	COG3447	MASE1 domain protein
CH59_3415	COG5002	protein histidine kinase activity
CH59_3415	COG5001	Diguanylate cyclase
CH59_3417	COG2226	methyltransferase
CH59_3419	COG1278	Cold shock
CH59_3422	COG1113	amino acid transport
CH59_3429	COG2207	Transcriptional regulator
CH59_343	COG0303	'Molybdopterin
CH59_3431	COG1132	(ABC) transporter
CH59_3441	COG3328	transposase activity
CH59_3442	COG4953	penicillin-binding protein 1C
CH59_3443	COG2373	Large extracellular alpha-helical protein
CH59_3449	COG3962	Belongs to the TPP enzyme family
CH59_345	COG3328	transposase activity
CH59_3450	COG0673	inositol 2-dehydrogenase activity
CH59_3451	COG0673	inositol 2-dehydrogenase activity
CH59_3452	COG1879	ABC-type sugar transport system periplasmic component
CH59_3455	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_3456	COG0673	inositol 2-dehydrogenase activity
CH59_3457	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH59_3459	COG3718	enzyme involved in inositol metabolism
CH59_3461	COG5265	(ABC) transporter
CH59_3466	COG2197	response regulator
CH59_3468	COG1278	Cold shock
CH59_3469	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH59_347	COG0488	(ABC) transporter
CH59_3470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH59_3474	COG1686	Belongs to the peptidase S11 family
CH59_3475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH59_3476	COG0772	Belongs to the SEDS family
CH59_3477	COG0768	penicillin binding
CH59_3479	COG0799	negative regulation of ribosome biogenesis
CH59_3481	COG1466	dna polymerase III delta subunit
CH59_3484	COG2888	peptidyl-tyrosine sulfation
CH59_3485	COG1126	abc transporter atp-binding protein
CH59_3486	COG0765	amino acid transport
CH59_3487	COG0765	amino acid transport
CH59_3489	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH59_3490	COG4535	Mg2 and Co2 transporter CorC
CH59_3492	COG1702	phosphate starvation-inducible protein PhoH
CH59_3494	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH59_35	COG1609	Transcriptional regulator
CH59_3500	COG0367	asparagine synthase
CH59_3501	COG0647	UMP catabolic process
CH59_3502	COG1846	Transcriptional regulator
CH59_3502	COG1940	carbohydrate kinase activity
CH59_3503	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH59_3505	COG1263	PTS System
CH59_3505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH59_3505	COG2190	(PTS) system
CH59_3506	COG1943	Transposase
CH59_3508	COG1943	Transposase
CH59_3513	COG0735	belongs to the Fur family
CH59_3517	COG0596	Alpha beta hydrolase
CH59_3519	COG2963	transposase activity
CH59_3520	COG0582	viral genome integration into host DNA
CH59_3524	COG2113	Glycine betaine
CH59_3525	COG4176	ABC-type proline glycine betaine transport system permease component
CH59_3526	COG4175	Glycine betaine
CH59_3527	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH59_3535	COG3328	transposase activity
CH59_3536	COG3328	transposase activity
CH59_3538	COG1278	Cold shock
CH59_3539	COG0747	negative chemotaxis
CH59_3541	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH59_3542	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH59_3543	COG1124	(ABC) transporter
CH59_3550	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH59_3552	COG4413	Urea transporter
CH59_3553	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH59_3555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH59_3556	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH59_3557	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH59_3558	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH59_3559	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH59_3560	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH59_3561	COG2169	Transcriptional regulator
CH59_3561	COG1917	Cupin 2, conserved barrel domain protein
CH59_3565	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH59_3566	COG0033	Phosphoglucomutase
CH59_3570	COG0745	RESPONSE REGULATOR receiver
CH59_3571	COG2205	protein histidine kinase activity
CH59_3576	COG3272	Protein of unknown function (DUF1722)
CH59_3578	COG5212	phosphodiesterase
CH59_3579	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH59_3581	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH59_3582	COG1984	allophanate hydrolase subunit 2
CH59_3593	COG0513	Belongs to the DEAD box helicase family
CH59_3595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH59_3597	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH59_3598	COG3026	antisigma factor binding
CH59_3599	COG3086	response to oxidative stress
CH59_36	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_3602	COG0681	Belongs to the peptidase S26 family
CH59_3610	COG3501	Rhs element vgr protein
CH59_3616	COG2824	Alkylphosphonate utilization operon protein PhnA
CH59_3618	COG1704	LemA family
CH59_3622	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH59_3623	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH59_3624	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH59_3626	COG1138	Cytochrome C-type biogenesis protein
CH59_3627	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH59_3628	COG3088	subunit of a heme lyase
CH59_3628	COG4235	cytochrome complex assembly
CH59_3629	COG4235	cytochrome complex assembly
CH59_3629	COG3088	subunit of a heme lyase
CH59_3632	COG3691	Protein conserved in bacteria
CH59_3635	COG2062	phosphohistidine phosphatase, SixA
CH59_3637	COG2890	protein-(glutamine-N5) methyltransferase activity
CH59_3639	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH59_3640	COG0730	response to heat
CH59_3641	COG3101	peptidyl-lysine hydroxylation
CH59_3644	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH59_3645	COG1794	racemase activity, acting on amino acids and derivatives
CH59_3648	COG0697	spore germination
CH59_3651	COG1943	Transposase
CH59_3652	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH59_3654	COG0586	Pfam SNARE associated Golgi protein
CH59_3656	COG0285	dihydrofolate synthase activity
CH59_3657	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH59_3658	COG1286	toxin biosynthetic process
CH59_3659	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH59_3660	COG0163	prenyltransferase activity
CH59_3661	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH59_3662	COG4215	(ABC) transporter
CH59_3663	COG4160	amino acid transport
CH59_3664	COG4598	ABC transporter
CH59_3665	COG1090	epimerase
CH59_3667	COG0622	Phosphoesterase
CH59_3668	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH59_3669	COG3037	sugar-specific permease SgaT UlaA
CH59_3670	COG3328	transposase activity
CH59_3671	COG4953	penicillin-binding protein 1C
CH59_3672	COG3423	Transcriptional regulator
CH59_3681	COG2850	peptidyl-arginine hydroxylation
CH59_3682	COG3328	transposase activity
CH59_3687	COG0656	L-ascorbic acid biosynthetic process
CH59_3688	COG0667	Aldo Keto reductase
CH59_37	COG1129	ABC transporter
CH59_3700	COG4771	TonB-dependent receptor
CH59_3701	COG1021	2,3-dihydroxybenzoate-AMP ligase
CH59_3705	COG3433	isochorismatase activity
CH59_3705	COG2226	methyltransferase
CH59_3705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH59_3708	COG1132	(ABC) transporter
CH59_3709	COG2814	Major facilitator Superfamily
CH59_3710	COG1169	isochorismate synthase
CH59_3711	COG0582	viral genome integration into host DNA
CH59_3713	COG3121	Chaperone
CH59_3715	COG3188	usher protein
CH59_3722	COG0427	acetyl-CoA hydrolase
CH59_3723	COG2030	dehydratase
CH59_3731	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH59_3732	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH59_3734	COG1349	DNA-binding transcription factor activity
CH59_3735	COG2066	Belongs to the glutaminase family
CH59_3737	COG0672	)-iron permease
CH59_3740	COG0577	efflux transmembrane transporter activity
CH59_3740	COG1136	(ABC) transporter
CH59_3743	COG0577	efflux transmembrane transporter activity
CH59_3743	COG1136	(ABC) transporter
CH59_3747	COG0006	proline dipeptidase activity
CH59_3748	COG0457	Tetratricopeptide repeat
CH59_3749	COG1649	PFAM Uncharacterised BCR, COG1649
CH59_3749	COG0726	polysaccharide deacetylase
CH59_3750	COG1215	transferase activity, transferring glycosyl groups
CH59_3751	COG3658	cytochrome
CH59_3754	COG1702	phosphate starvation-inducible protein PhoH
CH59_3755	COG0387	Pfam Sodium calcium exchanger
CH59_3756	COG3850	Histidine kinase
CH59_3757	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH59_376	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH59_377	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CH59_3770	COG1285	pathogenesis
CH59_3771	COG3042	response to heat
CH59_3772	COG3187	Heat shock protein
CH59_3773	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH59_3774	COG2911	Protein conserved in bacteria
CH59_3776	COG3784	Protein of unknown function (DUF1318)
CH59_3777	COG0246	Mannitol dehydrogenase
CH59_3778	COG2390	Transcriptional regulator
CH59_3780	COG1643	Atp-dependent helicase
CH59_3783	COG3591	Belongs to the peptidase S1B family
CH59_3785	COG3038	cytochrome b561
CH59_3789	COG1943	Transposase
CH59_379	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_3790	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH59_3791	COG2205	protein histidine kinase activity
CH59_3792	COG0745	RESPONSE REGULATOR receiver
CH59_3794	COG0531	amino acid
CH59_3796	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH59_3797	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH59_3798	COG0589	response to stress
CH59_3799	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH59_38	COG1879	ABC-type sugar transport system periplasmic component
CH59_380	COG1024	Enoyl-CoA hydratase
CH59_3800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH59_3804	COG1011	Hydrolase
CH59_3805	COG0440	acetolactate synthase activity
CH59_3806	COG0028	Belongs to the TPP enzyme family
CH59_3809	COG1943	Transposase
CH59_3813	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH59_3814	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH59_3815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH59_3816	COG1879	ABC-type sugar transport system periplasmic component
CH59_3818	COG1609	Transcriptional regulator
CH59_382	COG3425	synthase
CH59_3822	COG4128	Pfam Zonular occludens toxin
CH59_383	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_3836	COG4128	Pfam Zonular occludens toxin
CH59_384	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH59_3846	COG0038	chloride channel
CH59_3847	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH59_3849	COG1940	carbohydrate kinase activity
CH59_385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH59_3850	COG0583	DNA-binding transcription factor activity
CH59_3851	COG2814	Major facilitator Superfamily
CH59_3853	COG0114	fumarate hydratase activity
CH59_3855	COG5339	Protein conserved in bacteria
CH59_3857	COG0385	Bile acid
CH59_3858	COG0673	inositol 2-dehydrogenase activity
CH59_3862	COG0673	inositol 2-dehydrogenase activity
CH59_3864	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_3866	COG1879	ABC-type sugar transport system periplasmic component
CH59_387	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_3870	COG2274	protein secretion by the type I secretion system
CH59_3871	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH59_3878	COG2207	Transcriptional regulator
CH59_3878	COG3708	Transcriptional regulator
CH59_3879	COG4658	electron transport chain
CH59_3880	COG4659	FMN binding
CH59_3882	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH59_3883	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH59_3884	COG2271	Major facilitator Superfamily
CH59_3886	COG1966	Carbon starvation protein
CH59_3887	COG2879	small protein
CH59_3888	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH59_3892	COG0023	Translation Initiation Factor
CH59_3895	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH59_3896	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH59_3897	COG0671	phosphoesterase, PA-phosphatase related
CH59_3898	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH59_3899	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CH59_39	COG1063	alcohol dehydrogenase
CH59_3901	COG0583	DNA-binding transcription factor activity
CH59_3902	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH59_3905	COG0616	signal peptide processing
CH59_3906	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_3908	COG1187	pseudouridine synthase activity
CH59_3909	COG0009	L-threonylcarbamoyladenylate synthase
CH59_3912	COG0512	Glutamine amidotransferase of anthranilate synthase
CH59_3914	COG0134	indole-3-glycerol-phosphate synthase activity
CH59_3914	COG0135	phosphoribosylanthranilate isomerase activity
CH59_3918	COG3047	cAMP biosynthetic process
CH59_3923	COG1607	acyl-coa hydrolase
CH59_3924	COG3328	transposase activity
CH59_3925	COG3328	transposase activity
CH59_3926	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH59_3927	COG2350	Protein conserved in bacteria
CH59_3934	COG4608	Belongs to the ABC transporter superfamily
CH59_3935	COG0444	Belongs to the ABC transporter superfamily
CH59_3936	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH59_3937	COG0601	transmembrane transport
CH59_3939	COG2095	MarC family integral membrane protein
CH59_394	COG2920	part of a sulfur-relay system
CH59_3940	COG1454	alcohol dehydrogenase
CH59_3940	COG1012	belongs to the aldehyde dehydrogenase family
CH59_3944	COG1435	thymidine kinase activity
CH59_3947	COG0745	RESPONSE REGULATOR receiver
CH59_3949	COG3328	transposase activity
CH59_3950	COG0788	formyltetrahydrofolate deformylase activity
CH59_3951	COG3328	transposase activity
CH59_3954	COG0583	DNA-binding transcription factor activity
CH59_3955	COG0708	Exodeoxyribonuclease III
CH59_3956	COG0494	nUDIX hydrolase
CH59_3958	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH59_3959	COG0709	Synthesizes selenophosphate from selenide and ATP
CH59_3960	COG0778	Nitroreductase
CH59_3961	COG0616	signal peptide processing
CH59_3962	COG0252	asparaginase activity
CH59_3963	COG1335	isochorismatase
CH59_3964	COG3139	Protein of unknown function (DUF1315)
CH59_3968	COG3713	MltA-interacting MipA family protein
CH59_3969	COG2766	serine protein kinase
CH59_3972	COG0583	DNA-binding transcription factor activity
CH59_3974	COG2814	Major facilitator Superfamily
CH59_3976	COG2719	SpoVR family
CH59_398	COG1832	CoA-binding protein
CH59_3982	COG1104	cysteine desulfurase activity
CH59_3984	COG3328	transposase activity
CH59_3985	COG3328	transposase activity
CH59_399	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CH59_4001	COG1943	Transposase
CH59_401	COG0210	DNA helicase
CH59_4017	COG3328	transposase activity
CH59_4018	COG3328	transposase activity
CH59_402	COG3304	Inner membrane component domain
CH59_403	COG1289	transmembrane transporter activity
CH59_4039	COG0582	viral genome integration into host DNA
CH59_404	COG3070	regulator of competence-specific genes
CH59_4041	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH59_4042	COG2951	lytic endotransglycosylase activity
CH59_4045	COG2894	cell division
CH59_4046	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH59_4047	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH59_4048	COG0318	PFAM AMP-dependent synthetase and ligase
CH59_4049	COG3065	identical protein binding
CH59_4051	COG1199	ATP-dependent helicase activity
CH59_4052	COG0251	oxidation-reduction process
CH59_4055	COG0800	Aldolase
CH59_4057	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH59_4058	COG1737	Transcriptional regulator
CH59_4059	COG0469	pyruvate kinase activity
CH59_406	COG2885	chlorophyll binding
CH59_406	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH59_4060	COG1560	Kdo2-lipid A biosynthetic process
CH59_4061	COG0739	heme binding
CH59_4062	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH59_4064	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH59_4069	COG0494	nUDIX hydrolase
CH59_407	COG1943	Transposase
CH59_4071	COG1801	Protein of unknown function DUF72
CH59_4072	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH59_4076	COG3102	Protein conserved in bacteria
CH59_4081	COG0728	peptidoglycan biosynthetic process
CH59_4082	COG0673	inositol 2-dehydrogenase activity
CH59_4083	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH59_4086	COG3381	protein complex oligomerization
CH59_4089	COG1940	carbohydrate kinase activity
CH59_409	COG1067	ATP-dependent peptidase activity
CH59_4090	COG0584	glycerophosphoryl diester phosphodiesterase
CH59_4091	COG3842	ATPase activity
CH59_4092	COG1943	Transposase
CH59_4094	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH59_4095	COG3833	ABC-type maltose transport systems, permease component
CH59_4099	COG0659	secondary active sulfate transmembrane transporter activity
CH59_4102	COG0659	secondary active sulfate transmembrane transporter activity
CH59_4103	COG1943	Transposase
CH59_4105	COG2912	Transglutaminase-like superfamily
CH59_4106	COG3094	Invasion gene expression up-regulator, SirB
CH59_4107	COG2890	protein-(glutamine-N5) methyltransferase activity
CH59_4112	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH59_4115	COG0012	GTP binding
CH59_412	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH59_4126	COG5002	protein histidine kinase activity
CH59_4135	COG0500	methyltransferase
CH59_4140	COG3328	transposase activity
CH59_4141	COG3328	transposase activity
CH59_4151	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH59_4152	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CH59_4153	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CH59_4156	COG0402	S-adenosylhomocysteine deaminase activity
CH59_416	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH59_4164	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH59_4164	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH59_4164	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH59_4164	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH59_4167	COG2755	lipolytic protein G-D-S-L family
CH59_4167	COG0657	acetylesterase activity
CH59_417	COG1943	Transposase
CH59_4170	COG4166	transmembrane transport
CH59_4171	COG2866	Carboxypeptidase
CH59_4172	COG4948	Mandelate Racemase Muconate Lactonizing
CH59_4173	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH59_4174	COG1943	Transposase
CH59_4179	COG3106	COG3106 Predicted ATPase
CH59_418	COG3009	Protein conserved in bacteria
CH59_4181	COG1983	PspC domain protein
CH59_4183	COG1842	Phage shock protein A
CH59_4184	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH59_4185	COG1943	Transposase
CH59_4186	COG4166	transmembrane transport
CH59_4187	COG4168	peptide transport system, permease
CH59_4188	COG4171	peptide transport system, permease
CH59_419	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH59_419	COG3008	intermembrane lipid transfer
CH59_4190	COG4172	Belongs to the ABC transporter superfamily
CH59_4191	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH59_4191	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH59_4193	COG3104	oligopeptide transport
CH59_4196	COG0625	glutathione transferase activity
CH59_420	COG2995	paraquat-inducible protein a
CH59_4200	COG3895	Periplasmic Protein
CH59_4202	COG3133	Outer membrane lipoprotein
CH59_4204	COG4989	oxidoreductase activity
CH59_4205	COG3313	Fe-S protein
CH59_4206	COG2194	sulfuric ester hydrolase activity
CH59_4207	COG1309	transcriptional regulator
CH59_4208	COG1902	pentaerythritol trinitrate reductase activity
CH59_421	COG0488	(ABC) transporter
CH59_4210	COG0346	lactoylglutathione lyase activity
CH59_4211	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH59_4212	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH59_4214	COG0791	NLP P60 protein
CH59_4215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH59_4218	COG0583	DNA-binding transcription factor activity
CH59_4219	COG2814	Major facilitator Superfamily
CH59_4220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH59_4221	COG0307	riboflavin synthase, alpha
CH59_4226	COG4238	major outer membrane lipoprotein
CH59_4227	COG1943	Transposase
CH59_4228	COG1943	Transposase
CH59_423	COG0633	Ferredoxin
CH59_423	COG3217	Mosc domain protein beta barrel domain protein
CH59_4233	COG1376	ErfK ybiS ycfS ynhG family protein
CH59_4233	COG1388	LysM domain
CH59_4236	COG0719	Fe-S assembly protein
CH59_4237	COG0396	ATPase activity
CH59_4238	COG0719	Fe-S assembly protein
CH59_4239	COG0316	Belongs to the HesB IscA family
CH59_4240	COG2050	protein possibly involved in aromatic compounds catabolism
CH59_4241	COG0277	FAD linked oxidase domain protein
CH59_4241	COG0247	lactate metabolic process
CH59_4242	COG0628	permease
CH59_4243	COG0574	Belongs to the PEP-utilizing enzyme family
CH59_4243	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH59_4249	COG0791	NLP P60 protein
CH59_4257	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH59_4258	COG0386	Belongs to the glutathione peroxidase family
CH59_426	COG0308	aminopeptidase N
CH59_4261	COG0776	regulation of translation
CH59_4262	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH59_4262	COG0072	phenylalanine-tRNA ligase activity
CH59_4263	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CH59_4268	COG4249	Peptidase C14 caspase catalytic subunit p20
CH59_4272	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH59_4273	COG1121	(ABC) transporter
CH59_4274	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH59_4275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH59_4278	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH59_4279	COG3328	transposase activity
CH59_4283	COG0628	permease
CH59_4287	COG2771	luxR family
CH59_4288	COG3916	Acyl-homoserine-lactone synthase
CH59_4289	COG0583	DNA-binding transcription factor activity
CH59_4294	COG3941	tape measure
CH59_43	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH59_430	COG1448	Aminotransferase
CH59_431	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH59_4312	COG1475	DNA binding
CH59_4313	COG1475	DNA binding
CH59_4314	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH59_432	COG3108	Peptidase M15
CH59_4323	COG1943	Transposase
CH59_4329	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH59_433	COG2989	Protein conserved in bacteria
CH59_434	COG1943	Transposase
CH59_4340	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH59_4342	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH59_4353	COG1475	DNA binding
CH59_436	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CH59_4369	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH59_437	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH59_4371	COG3344	reverse transcriptase
CH59_4373	COG3328	transposase activity
CH59_4374	COG3328	transposase activity
CH59_438	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH59_4388	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CH59_439	COG3173	Aminoglycoside phosphotransferase
CH59_4390	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH59_4390	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH59_4393	COG4790	Type iii secretion
CH59_4394	COG4794	Type iii secretion
CH59_4395	COG4791	protein targeting
CH59_4396	COG4792	protein secretion
CH59_4398	COG2207	Transcriptional regulator
CH59_4407	COG4669	(LipO)protein
CH59_4409	COG1317	bacterial-type flagellum organization
CH59_441	COG2835	tetraacyldisaccharide 4'-kinase activity
CH59_4410	COG5599	Phosphatase
CH59_4411	COG2963	transposase activity
CH59_4412	COG2801	Transposase and inactivated derivatives
CH59_4416	COG2801	Transposase and inactivated derivatives
CH59_4418	COG0515	serine threonine protein kinase
CH59_442	COG1278	Cold shock
CH59_443	COG5383	Protein conserved in bacteria
CH59_4438	COG2801	Transposase and inactivated derivatives
CH59_4443	COG2801	Transposase and inactivated derivatives
CH59_4450	COG2801	Transposase and inactivated derivatives
CH59_4452	COG5599	Phosphatase
CH59_4454	COG3609	addiction module antidote protein, CC2985 family
CH59_4456	COG1475	DNA binding
CH59_4457	COG1192	Involved in chromosome partitioning
CH59_4459	COG2801	Transposase and inactivated derivatives
CH59_446	COG0658	competence protein
CH59_446	COG2333	competence protein COMEC
CH59_4463	COG3177	Filamentation induced by cAMP protein fic
CH59_4466	COG4886	Leucine-rich repeat (LRR) protein
CH59_4469	COG0457	Tetratricopeptide repeat
CH59_4473	COG4789	Type iii secretion
CH59_4483	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH59_4486	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CH59_449	COG0539	negative regulation of cytoplasmic translation
CH59_454	COG5295	Hep Hag repeat protein
CH59_454	COG5295	Hep Hag repeat protein
CH59_455	COG0252	asparaginase activity
CH59_456	COG1944	ATP diphosphatase activity
CH59_457	COG2116	formate transmembrane transporter activity
CH59_458	COG1882	Formate acetyltransferase
CH59_460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH59_461	COG2814	Major facilitator Superfamily
CH59_463	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH59_466	COG3107	peptidoglycan biosynthetic process
CH59_466	COG1674	ftsk spoiiie
CH59_468	COG0492	ferredoxin-NADP+ reductase activity
CH59_470	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH59_472	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH59_473	COG1943	Transposase
CH59_474	COG0542	response to heat
CH59_476	COG1278	Cold shock
CH59_478	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH59_479	COG2990	Protein conserved in bacteria
CH59_480	COG3593	DNA synthesis involved in DNA repair
CH59_481	COG2431	L-lysine efflux transmembrane transporter activity
CH59_483	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH59_484	COG0028	Belongs to the TPP enzyme family
CH59_485	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH59_486	COG0702	epimerase
CH59_487	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH59_489	COG1605	Chorismate mutase
CH59_49	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH59_490	COG1126	abc transporter atp-binding protein
CH59_491	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH59_492	COG4215	(ABC) transporter
CH59_493	COG4160	amino acid transport
CH59_497	COG1120	ATPase activity
CH59_498	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH59_50	COG0765	amino acid transport
CH59_503	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH59_507	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH59_51	COG1126	abc transporter atp-binding protein
CH59_510	COG1177	transmembrane transport
CH59_511	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH59_512	COG3842	ATPase activity
CH59_513	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH59_516	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH59_517	COG2985	domain, Protein
CH59_517	COG0569	domain protein
CH59_519	COG0671	phosphoesterase, PA-phosphatase related
CH59_520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH59_521	COG1349	DNA-binding transcription factor activity
CH59_522	COG0814	amino acid
CH59_523	COG1686	Belongs to the peptidase S11 family
CH59_524	COG2011	ABC-type metal ion transport system permease component
CH59_529	COG0625	glutathione transferase activity
CH59_530	COG4771	TonB-dependent receptor
CH59_532	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH59_534	COG0833	amino acid
CH59_536	COG0583	DNA-binding transcription factor activity
CH59_537	COG2855	membrane
CH59_539	COG3188	usher protein
CH59_540	COG3121	Chaperone
CH59_543	COG3710	Transcriptional regulator
CH59_544	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH59_544	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH59_544	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH59_545	COG1105	Belongs to the carbohydrate kinase PfkB family
CH59_547	COG0494	nUDIX hydrolase
CH59_548	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_549	COG1129	ABC transporter
CH59_551	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH59_556	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_560	COG1312	Catalyzes the dehydration of D-mannonate
CH59_561	COG0246	Mannitol dehydrogenase
CH59_562	COG2186	Transcriptional regulator
CH59_564	COG0523	cobalamin synthesis protein
CH59_565	COG0671	phosphoesterase, PA-phosphatase related
CH59_566	COG0791	NLP P60 protein
CH59_568	COG2200	EAL domain
CH59_569	COG4166	transmembrane transport
CH59_570	COG4174	ABC transporter (Permease)
CH59_571	COG4239	(ABC) transporter, permease
CH59_572	COG4172	Belongs to the ABC transporter superfamily
CH59_574	COG2814	Major facilitator Superfamily
CH59_575	COG1187	pseudouridine synthase activity
CH59_576	COG1061	Type III restriction enzyme res subunit
CH59_578	COG1943	Transposase
CH59_58	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH59_580	COG3082	Protein of unknown function (DUF1414)
CH59_581	COG3083	sulfuric ester hydrolase activity
CH59_584	COG3157	Type VI secretion system effector, Hcp
CH59_588	COG2723	6-phospho-beta-galactosidase activity
CH59_590	COG1737	Transcriptional regulator
CH59_594	COG3299	homolog of phage Mu protein gp47
CH59_602	COG4386	tail sheath protein
CH59_606	COG3622	Belongs to the hyi family
CH59_607	COG1349	DNA-binding transcription factor activity
CH59_608	COG0235	Class ii aldolase
CH59_609	COG3395	kinase activity
CH59_61	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH59_617	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH59_620	COG1943	Transposase
CH59_621	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH59_623	COG2223	nitrite transmembrane transporter activity
CH59_624	COG0642	Histidine kinase
CH59_624	COG2198	Histidine kinase
CH59_625	COG0642	Histidine kinase
CH59_625	COG2198	Histidine kinase
CH59_627	COG2205	protein histidine kinase activity
CH59_627	COG0784	Response regulator, receiver
CH59_632	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH59_635	COG0814	amino acid
CH59_64	COG1169	isochorismate synthase
CH59_640	COG0697	spore germination
CH59_642	COG1982	Orn Lys Arg decarboxylase major
CH59_643	COG0531	amino acid
CH59_644	COG1174	glycine betaine transport
CH59_645	COG1125	glycine betaine transport
CH59_646	COG1174	glycine betaine transport
CH59_649	COG2897	thiosulfate sulfurtransferase activity
CH59_652	COG0410	ABC transporter
CH59_653	COG1122	ATPase activity
CH59_657	COG4807	Protein conserved in bacteria
CH59_66	COG4575	ribosome binding
CH59_660	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CH59_662	COG2261	transglycosylase associated protein
CH59_664	COG1403	HNH endonuclease
CH59_666	COG0277	FAD linked oxidase domain protein
CH59_667	COG1686	Belongs to the peptidase S11 family
CH59_669	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH59_671	COG1943	Transposase
CH59_672	COG2211	Major facilitator Superfamily
CH59_673	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CH59_675	COG0583	DNA-binding transcription factor activity
CH59_676	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CH59_68	COG0129	dihydroxy-acid dehydratase activity
CH59_680	COG1943	Transposase
CH59_681	COG1943	Transposase
CH59_682	COG0670	Belongs to the BI1 family
CH59_683	COG0314	molybdopterin synthase activity
CH59_684	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH59_686	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH59_688	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH59_689	COG4628	conserved protein (DUF2132)
CH59_690	COG0556	nucleotide-excision repair
CH59_692	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH59_693	COG2226	methyltransferase
CH59_698	COG0561	phosphatase activity
CH59_700	COG4149	molybdate abc transporter
CH59_701	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH59_703	COG3585	molybdate ion transport
CH59_703	COG2005	Transcriptional regulator
CH59_704	COG1119	ATPase activity
CH59_707	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH59_708	COG1085	galactose-1-phosphate uridylyltransferase
CH59_71	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH59_711	COG2017	converts alpha-aldose to the beta-anomer
CH59_716	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH59_718	COG1230	cation diffusion facilitator family transporter
CH59_72	COG1609	Transcriptional regulator
CH59_724	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH59_725	COG2885	chlorophyll binding
CH59_727	COG3064	Membrane
CH59_727	COG3064	Membrane
CH59_728	COG0848	biopolymer transport protein
CH59_729	COG0811	peptide transport
CH59_730	COG0824	Thioesterase
CH59_731	COG3790	cyd operon protein YbgE
CH59_732	COG4890	Cyd operon protein YbgT
CH59_733	COG1294	oxidase, subunit
CH59_734	COG1271	oxidase subunit
CH59_735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH59_739	COG0567	Dehydrogenase, E1 component
CH59_74	COG1028	Short-chain dehydrogenase reductase Sdr
CH59_741	COG1053	succinate dehydrogenase
CH59_742	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH59_743	COG2009	succinate dehydrogenase
CH59_746	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH59_747	COG0497	DNA recombination
CH59_748	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH59_75	COG3265	gluconokinase activity
CH59_750	COG2867	negative regulation of translational initiation
CH59_752	COG1943	Transposase
CH59_753	COG0582	viral genome integration into host DNA
CH59_76	COG2731	YhcH YjgK YiaL family protein
CH59_763	COG3657	addiction module killer protein
CH59_769	COG1953	Uracil, thiamine, allantoin
CH59_771	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH59_773	COG2226	methyltransferase
CH59_775	COG1388	LysM domain
CH59_775	COG0741	lytic transglycosylase activity
CH59_778	COG0656	L-ascorbic acid biosynthetic process
CH59_784	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH59_786	COG2011	ABC-type metal ion transport system permease component
CH59_787	COG1464	Belongs to the NlpA lipoprotein family
CH59_789	COG1720	tRNA m6t6A37 methyltransferase activity
CH59_79	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH59_791	COG3015	lipoprotein NlpE involved in copper resistance
CH59_793	COG4681	YaeQ
CH59_795	COG4568	rho-dependent transcription termination
CH59_797	COG0037	tRNA processing
CH59_798	COG0346	lactoylglutathione lyase activity
CH59_8	COG1203	CRISPR-associated helicase, Cas3
CH59_80	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH59_800	COG0587	DNA-directed DNA polymerase activity
CH59_802	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH59_806	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH59_808	COG0750	zinc metalloprotease
CH59_809	COG0575	Belongs to the CDS family
CH59_810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CH59_816	COG0024	Methionine aminopeptidase
CH59_82	COG0839	Belongs to the complex I subunit 6 family
CH59_821	COG0564	pseudouridine synthase activity
CH59_822	COG3098	single-species biofilm formation
CH59_823	COG1943	Transposase
CH59_825	COG1943	Transposase
CH59_828	COG1611	Belongs to the LOG family
CH59_829	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH59_831	COG2363	Small membrane protein
CH59_832	COG0583	DNA-binding transcription factor activity
CH59_834	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH59_835	COG2166	iron-sulfur cluster assembly
CH59_836	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH59_837	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH59_840	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH59_842	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH59_843	COG1074	ATP-dependent DNA helicase activity
CH59_846	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH59_85	COG1034	ATP synthesis coupled electron transport
CH59_852	COG4771	TonB-dependent receptor
CH59_853	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH59_854	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CH59_863	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH59_865	COG5001	Diguanylate cyclase
CH59_865	COG3300	MHYT domain
CH59_866	COG2801	Transposase and inactivated derivatives
CH59_868	COG2211	Major facilitator Superfamily
CH59_87	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CH59_878	COG3916	Acyl-homoserine-lactone synthase
CH59_879	COG2771	luxR family
CH59_89	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH59_9	COG1518	maintenance of DNA repeat elements
CH59_901	COG1662	PFAM IS1 transposase
CH59_905	COG1982	Orn Lys Arg decarboxylase major
CH59_906	COG1879	ABC-type sugar transport system periplasmic component
CH59_907	COG1129	ABC transporter
CH59_908	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH59_909	COG4774	siderophore transport
CH59_91	COG0583	DNA-binding transcription factor activity
CH59_913	COG1194	a g-specific adenine glycosylase
CH59_915	COG3171	Protein conserved in bacteria
CH59_916	COG2066	Belongs to the glutaminase family
CH59_919	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CH59_919	COG3064	Membrane
CH59_919	COG1073	alpha beta
CH59_92	COG0436	Aminotransferase
CH59_920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH59_921	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH59_923	COG0762	integral membrane protein
CH59_924	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH59_925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH59_926	COG2805	Type II/IV secretion system protein
CH59_928	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH59_931	COG0189	ligase activity
CH59_932	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH59_933	COG2356	endonuclease I
CH59_934	COG3091	SprT-like family
CH59_937	COG1166	arginine decarboxylase activity
CH59_939	COG0501	Belongs to the peptidase M48B family
CH59_94	COG0490	domain, Protein
CH59_94	COG0471	metal ion transport
CH59_940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH59_941	COG1943	Transposase
CH59_944	COG0191	fructose-bisphosphate aldolase activity
CH59_949	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH59_95	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH59_950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH59_951	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH59_954	COG0006	proline dipeptidase activity
CH59_955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH59_956	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH59_962	COG5295	Hep Hag repeat protein
CH59_964	COG1272	protein, Hemolysin III
CH59_967	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CH59_968	COG0745	RESPONSE REGULATOR receiver
CH59_969	COG2205	protein histidine kinase activity
CH59_970	COG4452	Inner membrane protein CreD
CH59_971	COG0716	FMN binding
CH59_972	COG4974	Belongs to the 'phage' integrase family
CH59_973	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH59_974	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH59_978	COG0582	viral genome integration into host DNA
CH59_981	COG0582	viral genome integration into host DNA
CH59_986	COG2944	sequence-specific DNA binding
CH59_99	COG0280	phosphate acetyltransferase
CH59_99	COG0857	belongs to the CobB CobQ family