locus-tag class description GD372_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GD372_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GD372_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GD372_00025 ENOG410667J hydrolase GD372_00050 ENOG4105C7B Threonine dehydratase GD372_00065 ENOG4105R2A (LipO)protein GD372_00085 ENOG4105JKW Valine--pyruvate aminotransferase GD372_00105 ENOG4107T9C Alpha amylase catalytic region GD372_00125 ENOG4108ZG0 Ompa motb domain protein GD372_00135 ENOG4108R3E Dna-3-methyladenine glycosylase i GD372_00155 ENOG4106JH6 (LipO)protein GD372_00160 ENOG4105CTS PTS system mannitol-specific GD372_00170 ENOG4105E61 Mannitol repressor protein GD372_00175 ENOG4108YYI Protein of unknown function (DUF2810) GD372_00190 ENOG4105C8Q Methyl-accepting chemotaxis GD372_00195 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GD372_00210 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GD372_00215 ENOG4108MG3 formate dehydrogenase GD372_00230 ENOG4105EM7 Selenocysteine-specific translation elongation factor GD372_00275 ENOG4105MEV Acyl-transferase GD372_00280 ENOG4106EAR Fimbrial protein GD372_00290 ENOG4108TTM chaperone GD372_00300 ENOG4105CMG Carbohydrate kinase GD372_00310 ENOG4105DFW ABC transporter GD372_00320 ENOG4107RNG ABC transporter GD372_00325 ENOG4105T16 Transcriptional regulator (AraC family) GD372_00335 ENOG4105DFP Integrase GD372_00345 ENOG4105ZTC transcriptional activator, Ogr delta GD372_00385 ENOG4108IPW abc transporter atp-binding protein GD372_00390 ENOG4105CM4 permease protein GD372_00420 ENOG4105C6T cysteine synthase GD372_00430 ENOG4105C84 Histidine ammonia-lyase GD372_00435 ENOG4105C85 amino acid GD372_00445 ENOG4105DIJ Phosphoethanolamine transferase GD372_00450 ENOG4108KX4 response regulator GD372_00470 ENOG4105BZU Histidine kinase GD372_00475 ENOG4105CXY transporter GD372_00490 ENOG4105D5K Hemolysin activator protein GD372_00500 ENOG4105DEF Extracellular solute-binding protein, family 5 GD372_00505 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GD372_00510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GD372_00515 ENOG4105C3U ABC transporter GD372_00520 ENOG4108JQ7 (ABC) transporter GD372_00525 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) GD372_00530 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) GD372_00535 ENOG4105BZU Histidine kinase GD372_00540 ENOG4108PU9 oligogalacturonate-specific porin GD372_00560 ENOG4105CS0 peptidase GD372_00565 ENOG4107SS6 2-dehydro-3-deoxygluconokinase GD372_00570 ENOG4105VSH 4-oxalocrotonate tautomerase GD372_00575 ENOG4105CMB EAL domain-containing protein GD372_00580 ENOG41066T0 asmA family GD372_00585 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) GD372_00590 ENOG4107H3J ribonuclease GD372_00615 ENOG4105BZW Glycerate kinase GD372_00620 ENOG4107QQ0 gntp family GD372_00630 ENOG4107VHA regulatoR GD372_00635 ENOG4105DC8 reductase GD372_00640 ENOG4105D6S protein involved in catabolism of external DNA GD372_00645 ENOG4105DGW oligopeptidase A GD372_00665 ENOG4108M6U Universal stress protein A GD372_00680 ENOG4105CJ3 phosphate transporter GD372_00685 ENOG4105CBX hi0933 family GD372_00700 ENOG4105CNN ABC, transporter GD372_00705 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GD372_00715 ENOG4105D2N Aldolase GD372_00725 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD372_00740 ENOG4105C2I pirin domain protein GD372_00745 ENOG4105DIQ Transcriptional regulator GD372_00750 ENOG4105C6Z Gluconate GD372_00755 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GD372_00775 ENOG41076UM multiple antibiotic resistance (MarC)-related protein GD372_00780 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GD372_00810 ENOG4108HRK Histidine kinase GD372_00835 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GD372_00840 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GD372_00895 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GD372_00910 ENOG4105X58 receptor GD372_00925 ENOG4107QZV Type I secretion membrane fusion protein GD372_00930 ENOG4105YHG TonB family GD372_00935 ENOG4107QN2 dihydrolipoyl dehydrogenase GD372_00940 ENOG4105EHV domain protein GD372_00945 ENOG4105C5Q Transcriptional regulator GD372_00960 ENOG4108Y73 Membrane GD372_01020 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator GD372_01025 ENOG4105C2J ABC transporter GD372_01030 ENOG4107R9N ABC transporter GD372_01035 ENOG41062B0 ABC transporter, permease GD372_01045 ENOG4108WFC UPF0438 protein yifE GD372_01050 ENOG4105C0P Mg chelatase subunit ChlI GD372_01070 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit GD372_01075 ENOG4105CM2 brancheD-chain amino acid aminotransferase GD372_01085 ENOG4105C7B Threonine dehydratase GD372_01115 ENOG4105EMY transcriptional regulator GD372_01155 ENOG4108VEV chaperone GD372_01165 ENOG4105CW0 outer membrane usher protein GD372_01170 ENOG4105GQR Chaperone GD372_01195 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GD372_01205 ENOG4105C4R Atp-dependent dna helicase GD372_01220 ENOG4105K63 Thioredoxin GD372_01230 ENOG4105ESV Glycosyl transferase, family 4 GD372_01235 ENOG4105SFE lipopolysaccharide biosynthesis protein GD372_01240 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GD372_01245 ENOG4108IJ1 Dehydrogenase GD372_01250 ENOG4105C1B dTDP-glucose 4-6-dehydratase GD372_01255 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GD372_01260 ENOG4108WJ1 acetyltransferase GD372_01265 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GD372_01270 ENOG4105EGZ biosynthesis protein GD372_01290 ENOG4105C85 amino acid GD372_01325 ENOG410601J HemY protein GD372_01330 ENOG4105ECF c-methyltransferase GD372_01335 ENOG41076E6 Uroporphyrinogen-III Synthase GD372_01350 ENOG4107T0K Adenylate cyclase GD372_01360 ENOG4105S7Z (LipO)protein GD372_01370 ENOG4105CT0 Protein of unknown function, DUF484 GD372_01375 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GD372_01380 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GD372_01385 ENOG4105C4R Atp-dependent dna helicase GD372_01395 ENOG4105EQN UPF0261 protein GD372_01405 ENOG4107QUT magnesium and cobalt transport protein CorA GD372_01410 ENOG4105FR1 rard protein GD372_01415 ENOG4108VUY thioesterase Superfamily protein GD372_01420 ENOG4105HDD phospholipase GD372_01425 ENOG4105C9U ATP-dependent DNA helicase RecQ GD372_01430 ENOG4105CCF Lysine exporter protein (Lyse ygga) GD372_01440 ENOG4108EUD Lysophospholipase GD372_01445 ENOG4105DQF Hydrolase GD372_01455 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GD372_01470 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A GD372_01480 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GD372_01485 ENOG4108W1V Lipoprotein GD372_01490 ENOG4105EX9 Membrane GD372_01505 ENOG4107FS9 Membrane GD372_01520 ENOG4105MG3 Membrane GD372_01525 ENOG4106H78 methyltransferase GD372_01535 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GD372_01535 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GD372_01540 ENOG4105CAK Cell division ATP-binding protein ftsE GD372_01545 ENOG4105CRP Part of the ABC transporter FtsEX involved in GD372_01555 ENOG4108RS6 transposase GD372_01560 ENOG4105U59 -acetyltransferase GD372_01565 ENOG4105CP9 extracellular ligand-binding receptor GD372_01570 ENOG4105C32 Amino acid ABC transporter (Permease) GD372_01575 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GD372_01580 ENOG4105C0Z ABC transporter GD372_01585 ENOG4108IV0 ABC, transporter GD372_01645 ENOG4107T6V glycerophosphoryl diester phosphodiesterase GD372_01650 ENOG4105RK9 auxin efflux carrier GD372_01655 ENOG4105EMK carboxylate amino acid amine transporter GD372_01660 ENOG4105DZ2 Transcriptional regulator GD372_01670 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) GD372_01675 ENOG4108I5U Uridine phosphorylase GD372_01690 ENOG4108KF1 Membrane GD372_01695 ENOG4105CGY Dna recombination protein GD372_01705 ENOG4105JC1 sterol-binding domain protein GD372_01715 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GD372_01725 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GD372_01750 ENOG4105D52 delta-aminolevulinic acid dehydratase GD372_01755 ENOG4105MDZ Transcriptional activator rfaH GD372_01765 ENOG4107QK7 reductase GD372_01785 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GD372_01800 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GD372_01805 ENOG4108RR8 protoporphyrinogen oxidase GD372_01840 ENOG4105D4A Cell wall formation (By similarity) GD372_01845 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GD372_01895 ENOG4105PM1 preprotein translocase subunit SecE GD372_01900 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GD372_01935 ENOG4108RS6 transposase GD372_01945 ENOG4105D41 biosynthesis protein thiH GD372_01960 ENOG4105D06 uba thif-type nad fad binding protein GD372_01970 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GD372_01995 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GD372_02000 ENOG4105R2J Conserved Protein GD372_02010 ENOG4108T8B Protein of unknown function (DUF1481) GD372_02015 ENOG4105C12 Phosphoribosylglycinamide synthetase GD372_02090 ENOG41062QD Membrane GD372_02100 ENOG4105CK2 sodium dicarboxylate symporter GD372_02105 ENOG4105WH1 Two component transcriptional regulator luxr family GD372_02110 ENOG4105BZU Histidine kinase GD372_02170 ENOG4108JIR Flagellum-specific ATP synthase GD372_02185 ENOG41063Q7 Type III secretion system protein GD372_02190 ENOG4108HHI Type III secretion system protein GD372_02195 ENOG41083GP type iii secretion GD372_02200 ENOG4108TN6 type iii secretion GD372_02205 ENOG4108IUF type iii secretion GD372_02210 ENOG41066VF YeeE YedE family protein GD372_02215 ENOG4105KSU Redox protein GD372_02220 ENOG4105EQ2 LysR family Transcriptional regulator GD372_02225 ENOG4105C44 Serine transporter GD372_02230 ENOG4105C28 cystathionine GD372_02240 ENOG4105EHG Permease protein GD372_02245 ENOG4107R4I Periplasmic binding protein GD372_02250 ENOG4106QJH hemin transport protein GD372_02255 ENOG4107ENK receptor GD372_02270 ENOG41090JE Utilization Protein GD372_02275 ENOG4105D4P Coproporphyrinogen iii oxidase GD372_02295 ENOG4105DAX Pfam:DUF2983 GD372_02355 ENOG4108S1B Periplasmic chaperone protein GD372_02410 ENOG41080IJ Diacylglycerol kinase GD372_02420 ENOG4105MYN Zinc uptake regulation protein GD372_02425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GD372_02430 ENOG4105P4Z Phage shock protein G GD372_02435 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GD372_02440 ENOG4105CDU Replicative dna helicase GD372_02445 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GD372_02450 ENOG4105CGF Aromatic amino acid aminotransferase GD372_02455 ENOG4105MSB protein, conserved in bacteria GD372_02460 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GD372_02465 ENOG4108UUM single-stranded DNA-binding protein GD372_02475 ENOG4105C0A alcohol dehydrogenase GD372_02545 ENOG4108SIC Transcriptional regulator GD372_02555 ENOG4105BZ8 glutamate synthase GD372_02560 ENOG4108RC0 Electron transport protein GD372_02565 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GD372_02580 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GD372_02610 ENOG4108ZVF (LipO)protein GD372_02615 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GD372_02625 ENOG4105KPY Small multidrug resistance protein GD372_02630 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GD372_02660 ENOG4105EGS Mechanosensitive ion channel GD372_02680 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GD372_02700 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GD372_02705 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GD372_02710 ENOG4105K8N protein family UPF0079, ATPase GD372_02715 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GD372_02735 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GD372_02740 ENOG4107QJR hflk protein GD372_02745 ENOG4105EPW hflc protein GD372_02765 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GD372_02770 ENOG4105C2N RNA methyltransferase TrmH family group 3 GD372_02775 ENOG4105CSU acyl-Coa dehydrogenase GD372_02780 ENOG4105WSB biofilm stress and motility protein A GD372_02800 ENOG4108MXZ Esterase GD372_02810 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GD372_02820 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GD372_02830 ENOG4108RS6 transposase GD372_02840 ENOG4105FHY Opacity-associated protein A GD372_02845 ENOG4108V1T peptidylprolyl cis-trans isomerase GD372_02855 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GD372_02860 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GD372_02865 ENOG4108UUE Transcriptional regulator GD372_02870 ENOG41061GZ Protein of unknown function (DUF1107) GD372_02875 ENOG4105C37 (CBS) domain GD372_02885 ENOG4105CFU surface antigen GD372_02890 ENOG4105MA0 exported protein GD372_02895 ENOG4108ZHD aig2 family GD372_02900 ENOG4105F0N pyrophosphate phospho-hydrolase GD372_02910 ENOG4105DFU Cell wall formation (By similarity) GD372_02935 ENOG4105HVQ Regulatory factor of maltose metabolism GD372_02945 ENOG4105EAH synthase GD372_02960 ENOG4105QYV Membrane GD372_02980 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase GD372_02985 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GD372_02990 ENOG4105HBR Rna-binding protein GD372_03000 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GD372_03005 ENOG4105EEI dihydropteroate synthase GD372_03035 ENOG4105CHV Transcription elongation factor NusA GD372_03080 ENOG4105C1J atp-dependent rna helicase GD372_03105 ENOG4105DEN Luciferase family GD372_03115 ENOG4105BZS acriflavin resistance protein GD372_03120 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GD372_03125 ENOG4106RZ4 Peptidase U32 GD372_03130 ENOG4105CFP Peptidase U32 GD372_03140 ENOG4105XPQ lipid carrier protein GD372_03145 ENOG4108YYD acetyltransferase GD372_03170 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GD372_03175 ENOG4105DRS transport system, permease GD372_03195 ENOG4105K4T epimerase GD372_03205 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) GD372_03210 ENOG4105FD8 phosphonate metabolism protein PhnM GD372_03215 ENOG4105HRV phosphonate c-p lyase system protein phnl GD372_03220 ENOG4105ENV phosphonate C-P lyase system protein PhnK GD372_03225 ENOG4105FT8 Phosphonate metabolism GD372_03230 ENOG4105EKV Phosphonate metabolism protein GD372_03235 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH GD372_03240 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG GD372_03245 ENOG4107RJJ Transcriptional regulator GD372_03250 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GD372_03255 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GD372_03260 ENOG4108JQ7 (ABC) transporter GD372_03265 ENOG4105C3U ABC transporter GD372_03270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GD372_03275 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GD372_03285 ENOG4105XEP YhcH YjgK YiaL family protein GD372_03290 ENOG4105DBV ornithine carbamoyltransferase GD372_03295 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) GD372_03300 ENOG4108MJ3 acetyltransferase GD372_03305 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GD372_03310 ENOG4105MYG DNA polymerase iii, chi subunit GD372_03320 ENOG4108M8S permease YjgP YjgQ family protein GD372_03325 ENOG4108K5H permease YjgP YjgQ family protein GD372_03345 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GD372_03375 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GD372_03390 ENOG4105D7Q type ii secretion system GD372_03395 ENOG4107QHF type ii secretion system protein e GD372_03400 ENOG4108ZUW Major pilin subunit GD372_03405 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GD372_03410 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GD372_03415 ENOG4106A72 regulatory protein AmpE GD372_03420 ENOG4105C85 amino acid GD372_03430 ENOG41073TP transcriptional regulator GD372_03435 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GD372_03440 ENOG4107QSN dihydrolipoamide acetyltransferase GD372_03445 ENOG4107QN2 dihydrolipoyl dehydrogenase GD372_03450 ENOG4108RS6 transposase GD372_03455 ENOG4107QIJ Aconitate hydratase 2 GD372_03465 ENOG4105RPH Inner membrane protein YddG GD372_03480 ENOG4108ZRK uncharacterized protein yacC GD372_03485 ENOG4105E3B Multicopper oxidase GD372_03490 ENOG4108UGV hypoxanthine phosphoribosyltransferase GD372_03495 ENOG41077A9 carbonic anhydrase GD372_03500 ENOG4105DA5 (ABC) transporter GD372_03505 ENOG4105E3A (ABC) transporter GD372_03530 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GD372_03535 ENOG4105DJ0 Poly(A) Polymerase GD372_03540 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GD372_03550 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GD372_03560 ENOG4107XID 2'-5' rna ligase GD372_03565 ENOG4105CQ7 ATP-dependent helicase GD372_03570 ENOG4105BZ4 penicillin-binding protein GD372_03575 ENOG4105E0A ABC, transporter GD372_03580 ENOG4105J76 Periplasmic binding protein GD372_03585 ENOG4105S6R Iron-hydroxamate transporter permease subunit GD372_03605 ENOG4105EN6 Membrane GD372_03615 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GD372_03625 ENOG4105C0H protease GD372_03630 ENOG4105BZU Histidine kinase GD372_03640 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GD372_03645 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GD372_03650 ENOG4105DXN mazG family GD372_03670 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GD372_03675 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GD372_03730 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GD372_03735 ENOG4105N0Z inner membrane protein ygbE GD372_03745 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GD372_03770 ENOG4108K5P (LipO)protein GD372_03775 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD372_03780 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GD372_03785 ENOG4108YZG isomerase GD372_03790 ENOG4105CPQ Dehydrogenase GD372_03795 ENOG4105CHR reductase GD372_03800 ENOG4105CMT Dihydroxyacetone kinase GD372_03810 ENOG4105DKT Transcriptional regulator GD372_03835 ENOG4105E89 ABC transporter GD372_03840 ENOG4105CA0 peroxidase GD372_03850 ENOG4105D05 Receptor GD372_03860 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GD372_03870 ENOG4107GFK fumarate GD372_03875 ENOG4105CMG Carbohydrate kinase GD372_03880 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase GD372_03885 ENOG4105F5R ABC transporter GD372_03890 ENOG4105CNN ABC, transporter GD372_03895 ENOG4105C2J ABC transporter GD372_03900 ENOG4108RS6 transposase GD372_03910 ENOG4105E98 transcriptional regulator DeoR family GD372_03915 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GD372_03920 ENOG4107QY8 reductase GD372_03925 ENOG4105QAX Iron-sulfur GD372_03930 ENOG4107KGK dmso reductase anchor subunit GD372_03935 ENOG4108NEM leader-binding protein dmsD GD372_03940 ENOG4105CPW cytochrome b561 GD372_03945 ENOG4108XVM Cytochrome b(562) GD372_03965 ENOG4105C2J ABC transporter GD372_03970 ENOG4105CNN ABC, transporter GD372_03975 ENOG4108HHA Transketolase GD372_03980 ENOG4108IUS Transketolase GD372_03985 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GD372_04025 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GD372_04030 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GD372_04060 ENOG4107VXZ Hydrolase GD372_04065 ENOG4105W39 Membrane GD372_04070 ENOG4105D9M gamma-glutamylcysteine synthetase GD372_04085 ENOG4108JU6 CBS domain protein GD372_04090 ENOG4106KVJ cytochrome C assembly protein GD372_04095 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GD372_04125 ENOG4108NE3 Salt-induced outer membrane protein GD372_04135 ENOG4108NEV two component transcriptional regulator, LytTR family GD372_04140 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GD372_04145 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GD372_04170 ENOG4107ZSV Receptor GD372_04175 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GD372_04180 ENOG4105CFC Transporter GD372_04235 ENOG4105C1P efflux transporter, rnd family, mfp subunit GD372_04255 ENOG4105CT4 transporter GD372_04265 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GD372_04270 ENOG4105DUU IucA IucC family protein GD372_04355 ENOG4105CDV Ompa motb domain protein GD372_04365 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GD372_04440 ENOG4105CXN decarboxylase GD372_04445 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GD372_04450 ENOG4105C2J ABC transporter GD372_04455 ENOG4105CNN ABC, transporter GD372_04480 ENOG4105CEN a g-specific adenine glycosylase GD372_04490 ENOG41090ED Protein with unknown function (DUF469) GD372_04495 ENOG4105CSV Glutaminase GD372_04505 ENOG4105EUK rtx toxin RtxA GD372_04510 ENOG4105CSA Coproporphyrinogen iii oxidase GD372_04515 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GD372_04525 ENOG4108VIA integral membrane protein GD372_04535 ENOG4105II7 pyrroline-5-carboxylate reductase GD372_04540 ENOG4105DFA alanine racemase domain protein GD372_04545 ENOG4105CZX twitching motility protein GD372_04555 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) GD372_04570 ENOG4105D7Z glutathione synthase GD372_04575 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GD372_04580 ENOG4105RWS endonuclease I GD372_04595 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) GD372_04610 ENOG4108K0D peptidase, M48 GD372_04615 ENOG4105CV1 Transketolase (EC 2.2.1.1) GD372_04650 ENOG4105D2N Aldolase GD372_04660 ENOG4105D64 Mechanosensitive ion channel GD372_04670 ENOG4105MPN Membrane GD372_04680 ENOG4105E66 phosphoriboisomerase A GD372_04685 ENOG4108JQ1 Dehydrogenase GD372_04690 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GD372_04710 ENOG4107RAQ aminopeptidase GD372_04715 ENOG4105D0A hydroxylase GD372_04720 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GD372_04765 ENOG4108UT2 hemolysin iii GD372_04780 ENOG4105Y75 tpr repeat protein GD372_04790 ENOG4105E3W Two component transcriptional regulator (Winged helix family GD372_04795 ENOG4105EB3 Histidine kinase GD372_04800 ENOG4105CT7 inner membrane cred family protein GD372_04805 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GD372_04810 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GD372_04815 ENOG4105T95 Thiol disulfide interChange protein GD372_04820 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GD372_04840 ENOG4105DFP Integrase GD372_04860 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation GD372_04865 ENOG4105WJ3 XRE family Transcriptional regulator GD372_04955 ENOG4105NTW Transcriptional regulator GD372_04960 ENOG4108UY0 (LipO)protein GD372_04970 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GD372_04975 ENOG4105CNN ABC, transporter GD372_04990 ENOG4107FKK extracellular solute-binding protein family 1 GD372_05000 ENOG4105EG2 ABC transporter, permease GD372_05010 ENOG4105C4C beta-galactosidase GD372_05015 ENOG4105CI1 PTS System GD372_05025 ENOG4105ETE Transcriptional regulator (LacI family GD372_05035 ENOG4105DPW Major facilitator superfamily MFS_1 GD372_05040 ENOG4105ETE Transcriptional regulator (LacI family GD372_05055 ENOG4105D2N Aldolase GD372_05065 ENOG4105ENH Sulfatase GD372_05070 ENOG4105C4X radical SAM domain protein GD372_05080 ENOG4105CHR reductase GD372_05085 ENOG4105CE4 GlcNAc 6-P deacetylase GD372_05090 ENOG4108YTN IIa component GD372_05095 ENOG4105F3R pts system mannose fructose sorbose family iid GD372_05100 ENOG4105ETZ PTS System GD372_05105 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB GD372_05110 ENOG4105E70 isomerase GD372_05115 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GD372_05120 ENOG4105E98 transcriptional regulator DeoR family GD372_05125 ENOG4105CBG Sulfatase GD372_05130 ENOG4108RS6 transposase GD372_05170 ENOG4107B2H carbonic anhydrase GD372_05195 ENOG4107QHF type ii secretion system protein e GD372_05205 ENOG4105D7Q type ii secretion system GD372_05265 ENOG4105C8Q Methyl-accepting chemotaxis GD372_05280 ENOG4105EJC lysr family transcriptional regulator GD372_05285 ENOG4105F27 Major Facilitator GD372_05290 ENOG4105RQF LysR family Transcriptional regulator GD372_05295 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GD372_05300 ENOG41060NJ transcriptional regulator GD372_05330 ENOG4105CPC Aldo Keto reductase GD372_05360 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GD372_05400 ENOG4105DSY exodeoxyribonuclease V, gamma GD372_05405 ENOG4107QXK peptidase GD372_05410 ENOG4107QKA exodeoxyribonuclease V beta GD372_05415 ENOG4107QYX exodeoxyribonuclease v alpha GD372_05425 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GD372_05440 ENOG4105CA3 membrane-bound lytic murein transglycosylase GD372_05445 ENOG4105CUZ uba thif-type nad fad binding protein GD372_05450 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GD372_05455 ENOG4105C9B Cysteine desulfurase GD372_05465 ENOG4105ETT transcriptional Regulator, LysR family GD372_05470 ENOG4105M08 Membrane GD372_05480 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease GD372_05490 ENOG4105EWT decarboxylase family GD372_05515 ENOG4108RS6 transposase GD372_05520 ENOG4105WP7 tRNA pseudouridine synthase C GD372_05525 ENOG4105DR9 pseudouridine synthase GD372_05530 ENOG4105QDK Flavodoxin GD372_05550 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GD372_05585 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GD372_05590 ENOG4105KNE Phosphatidate cytidylyltransferase GD372_05595 ENOG4105DZP Membrane-associated zinc metalloprotease GD372_05605 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) GD372_05625 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GD372_05635 ENOG4105C0B DNA polymerase III (alpha subunit) GD372_05645 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GD372_05650 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GD372_05660 ENOG4105M1T rho-binding antiterminator GD372_05670 ENOG4108VWS Yaeq family GD372_05675 ENOG4108YZN class I peptide chain release factor GD372_05680 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion GD372_05690 ENOG4108R96 Methyltransferase, YaeB family GD372_05695 ENOG4108R8X outer membrane lipoprotein GD372_05700 ENOG4105D01 (LipO)protein GD372_05705 ENOG4108UMI ABC transporter, permease GD372_05715 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GD372_05750 ENOG4105CV8 reductase GD372_05765 ENOG4105E9H Lytic Murein transglycosylase GD372_05775 ENOG4105D1A Methyltransferase GD372_05785 ENOG4108JDX DNA polymerase iii, epsilon subunit GD372_05795 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GD372_05830 ENOG4108Z1B Cyclase dehydrase GD372_05840 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GD372_05845 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GD372_05850 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GD372_05860 ENOG4105BZN citrate synthase GD372_05865 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GD372_05870 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GD372_05880 ENOG4105E33 succinate dehydrogenase GD372_05885 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GD372_05890 ENOG4105C7S Dehydrogenase GD372_05900 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GD372_05905 ENOG4105C4M (Ubiquinol oxidase) subunit I GD372_05910 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GD372_05920 ENOG4105KJB cyd operon protein YbgE GD372_05925 ENOG4107YD3 Thioesterase GD372_05930 ENOG4105E02 MotA TolQ exbB proton channel GD372_05935 ENOG4105M8F Biopolymer transport protein exbD tolR GD372_05940 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA GD372_05940 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA GD372_05950 ENOG4105KCK Peptidoglycan-associated lipoprotein GD372_05955 ENOG4105UFD tol-pal system protein YbgF GD372_05980 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GD372_05985 ENOG4105PGM cation diffusion facilitator family transporter GD372_05990 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GD372_06005 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GD372_06020 ENOG4105F0Z galactose-1-phosphate uridylyltransferase GD372_06025 ENOG4105CMR udp-glucose 4-epimerase GD372_06035 ENOG4105DKW ABC transporter GD372_06045 ENOG4105F4R Transcriptional regulator mode GD372_06050 ENOG410680R Protein of unknown function (DUF2592) GD372_06055 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GD372_06060 ENOG4105E0C molybdate abc transporter GD372_06070 ENOG4108K4B hydrolase GD372_06095 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GD372_06100 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GD372_06105 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GD372_06110 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GD372_06115 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GD372_06120 ENOG4105CHW UPF0052 protein GD372_06125 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GD372_06135 ENOG4105M00 molybdopterin converting factor, subunit 1 GD372_06140 ENOG4108ZAF Molybdopterin GD372_06145 ENOG4105HFZ Membrane GD372_06165 ENOG4105BZU Histidine kinase GD372_06175 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GD372_06195 ENOG4107QWP ABC-2 type transporter GD372_06200 ENOG4107QWP ABC-2 type transporter GD372_06205 ENOG4105CJ1 ABC, transporter GD372_06215 ENOG4107MVR Transcriptional regulator GD372_06220 ENOG4105C1J atp-dependent rna helicase GD372_06280 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GD372_06290 ENOG41061WM D-Alanyl-D-Alanine GD372_06295 ENOG4105CXG d-lactate dehydrogenase GD372_06305 ENOG4105N1F Hnh endonuclease GD372_06315 ENOG4105Y3U Transglycosylase-associated protein GD372_06325 ENOG4106ZX3 phosphonate ABC transporter, periplasmic phosphonate-binding protein GD372_06340 ENOG4108W15 Protein of unknown function (DUF1456) GD372_06350 ENOG4105C32 Amino acid ABC transporter (Permease) GD372_06355 ENOG4105CNN ABC, transporter GD372_06360 ENOG4108JJB ABC transporter GD372_06365 ENOG4108IV0 ABC, transporter GD372_06385 ENOG4105KHC sulfurtransferase GD372_06390 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GD372_06395 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GD372_06400 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component GD372_06405 ENOG4108IJ8 ABC transporter GD372_06410 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component GD372_06415 ENOG4105D5Q Arginine ornithine antiporter GD372_06420 ENOG4105CXN decarboxylase GD372_06430 ENOG4105FDR Membrane GD372_06445 ENOG4105DVT helicase GD372_06450 ENOG4105CH6 catalase GD372_06455 ENOG4108UII YfaZ family GD372_06460 ENOG4105E0U tyrosine-specific transport protein GD372_06475 ENOG4105XPH Ferredoxin GD372_06480 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GD372_06485 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GD372_06495 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GD372_06500 ENOG4105BZU Histidine kinase GD372_06505 ENOG41068CG regulatoR GD372_06510 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC GD372_06515 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC GD372_06520 ENOG4106UW1 Major Facilitator superfamily GD372_06525 ENOG4105FCK Membrane GD372_06550 ENOG4107R6D beta-lactam binding protein AmpH GD372_06555 ENOG4105CT4 transporter GD372_06565 ENOG4105C8Q Methyl-accepting chemotaxis GD372_06580 ENOG4105Y50 Virulence Protein GD372_06590 ENOG4105HRS Antitermination protein GD372_06595 ENOG4105G63 Type III effector Hrp-dependent GD372_06605 ENOG4105MVE transcriptional regulator GD372_06610 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GD372_06630 ENOG4105TKZ Tail Sheath GD372_06670 ENOG4108T86 baseplate J family protein GD372_06690 ENOG4108Q3X Transcriptional regulator GD372_06695 ENOG4105CS2 ec 3.2.1.21 GD372_06710 ENOG4105GMB type VI secretion system effector, hcp1 family GD372_06730 ENOG4105E68 Sulfatase GD372_06735 ENOG4105PAN UPF0352 protein GD372_06745 ENOG4108RS6 transposase GD372_06760 ENOG4105CFI type iii restriction protein res subunit GD372_06765 ENOG4105I08 Pseudouridine synthase GD372_06770 ENOG4105C2C drug resistance transporter, Bcr CflA GD372_06775 ENOG4105HG6 GD372_06780 ENOG4108JQ5 ABC transporter GD372_06785 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GD372_06790 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GD372_06795 ENOG4105E43 Extracellular solute-binding protein, family 5 GD372_06800 ENOG4105CXC rtn protein GD372_06805 ENOG4107TT5 NLP P60 protein GD372_06810 ENOG41076MN Phosphoesterase, PA-phosphatase related GD372_06815 ENOG4105CKI cobalamin synthesis protein GD372_06825 ENOG4107YCY Transcriptional regulator GD372_06830 ENOG4105DEI Mannitol dehydrogenase GD372_06835 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GD372_06850 ENOG4105KRS Proteinase inhibitor GD372_06855 ENOG4105CHR reductase GD372_06875 ENOG4105C26 Dehydrogenase GD372_06885 ENOG4105E66 phosphoriboisomerase A GD372_06895 ENOG4105C2J ABC transporter GD372_06900 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GD372_06910 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GD372_06915 ENOG4105DE4 1-phosphofructokinase GD372_06920 ENOG4105DM4 PTS System GD372_06925 ENOG4108SGD regulatory protein GD372_06940 ENOG4108UIF Chaperone GD372_06945 ENOG4108D1K outer membrane usher protein GD372_06955 ENOG4105HMI Membrane GD372_06960 ENOG4105DUM transcriptional regulator, lysR family GD372_06965 ENOG4108IQI permease GD372_06975 ENOG4105EHG Permease protein GD372_06985 ENOG4105D05 Receptor GD372_06995 ENOG4108TGY Glutathione S-transferase GD372_07010 ENOG4105D01 (LipO)protein GD372_07020 ENOG4108UMI ABC transporter, permease GD372_07025 ENOG4105DZ1 carboxypeptidase GD372_07030 ENOG4105C44 Serine transporter GD372_07035 ENOG4107FB0 transcriptional regulator DeoR family GD372_07040 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GD372_07045 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GD372_07055 ENOG4105D0C transport protein GD372_07060 ENOG41090BQ Glutaredoxin GD372_07065 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress GD372_07075 ENOG4108RMJ sensory transduction regulator GD372_07080 ENOG4107RUE extracellular solute-binding protein family 1 GD372_07110 ENOG4105WT8 Protein of unknown function (DUF1480) GD372_07125 ENOG4105GQR Chaperone GD372_07145 ENOG4105DY2 Paraquat-inducible protein b GD372_07150 ENOG4105H2K paraquat-inducible protein a GD372_07155 ENOG4108ZGC gaf domain protein GD372_07165 ENOG4105CN1 protease GD372_07180 ENOG4105H8W Fimbrial protein GD372_07185 ENOG4108VEV chaperone GD372_07200 ENOG4108VEV chaperone GD372_07205 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD372_07210 ENOG4105CAZ oligogalacturonide lyase GD372_07220 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GD372_07225 ENOG4108ETY sodium dicarboxylate symporter GD372_07230 ENOG4107K5X Membrane-bound metal-dependent hydrolase GD372_07235 ENOG4108PU9 oligogalacturonate-specific porin GD372_07240 ENOG4105WEM extracellular solute-binding protein GD372_07250 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GD372_07255 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GD372_07260 ENOG41061NF Pectate lyase GD372_07265 ENOG4105CHR reductase GD372_07275 ENOG4105M5J Cupin 2, conserved barrel domain protein GD372_07285 ENOG4105TNG K13735 adhesin invasin GD372_07290 ENOG4105CSP Major Facilitator Superfamily GD372_07295 ENOG4105KIR Thiol-disulfide oxidoreductase dcc GD372_07300 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GD372_07310 ENOG4105DIA mandelate racemase muconate lactonizing GD372_07330 ENOG4105UQX Mate efflux family protein GD372_07350 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme GD372_07360 ENOG4108KX4 response regulator GD372_07365 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GD372_07375 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GD372_07380 ENOG4108TSE Transferase GD372_07395 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GD372_07455 ENOG4105BZ1 (ABC) transporter GD372_07475 ENOG4105N4N Protein of unknown function (DUF2766) GD372_07490 ENOG41064PC GD372_07510 ENOG4105C85 amino acid GD372_07525 ENOG410610J Protein of unknown function (DUF2627) GD372_07530 ENOG4105VEQ Cold shock protein GD372_07535 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GD372_07540 ENOG4105DHI Methyltransferase GD372_07550 ENOG4105BZU Histidine kinase GD372_07570 ENOG4105F3R pts system mannose fructose sorbose family iid GD372_07575 ENOG4105ETZ PTS System GD372_07580 ENOG4108EQA pts system GD372_07585 ENOG4105EE5 Membrane protein terC GD372_07595 ENOG4108V8F Transcriptional regulator, MarR family GD372_07610 ENOG4105C26 Dehydrogenase GD372_07615 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase GD372_07640 ENOG4105EFA 4-hydroxyphenylacetate GD372_07645 ENOG4107UWN reductase GD372_07650 ENOG4105EJQ L-serine dehydratase GD372_07660 ENOG4105CRQ synthase (Component I) GD372_07675 ENOG4105C1J atp-dependent rna helicase GD372_07680 ENOG4105X2V dna damage-inducible protein GD372_07695 ENOG4105CUG Oligopeptidase b GD372_07705 ENOG4105MPK DNA polymerase III subunit theta GD372_07710 ENOG41090A1 ferritin GD372_07715 ENOG4105FXM Copper resistance protein GD372_07725 ENOG4105NKT exported protein GD372_07745 ENOG4105D00 flagellar biosynthetic protein flhB GD372_07750 ENOG4105D7B Flagellar biosynthesis protein flha GD372_07755 ENOG4105W13 flagellar protein GD372_07775 ENOG4105QVD Flagella synthesis protein FlgN GD372_07780 ENOG4105M9M anti-sigma28 factor FlgM GD372_07785 ENOG4105CKS Flagella basal body P-ring formation protein flgA GD372_07790 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GD372_07795 ENOG4108ZC9 flagellar basal-body rod protein flgc GD372_07800 ENOG4105W00 Flagellar hook capping protein GD372_07805 ENOG4105BZE flagellar hook protein, FlgE GD372_07815 ENOG4105CGA flagellar basal-body rod protein FlgG GD372_07830 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GD372_07835 ENOG4105E1Q flagellar hook-associated protein GD372_07840 ENOG4105DTJ flagellar hook-associated protein GD372_07845 ENOG4105DKT Transcriptional regulator GD372_07855 ENOG4105CNN ABC, transporter GD372_07865 ENOG4105C2J ABC transporter GD372_07870 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GD372_07875 ENOG4108MGF sugar kinase GD372_07890 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GD372_07895 ENOG4105VS8 Flagellar biosynthetic protein fliq GD372_07900 ENOG4105CN7 Flagellar biosynthetic protein FliP GD372_07910 ENOG4105DD5 Flagellar motor switch protein GD372_07915 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GD372_07920 ENOG4107ZI8 flagellar basal body-associated protein flil GD372_07925 ENOG4105WF4 Flagellar hook-length control protein GD372_07930 ENOG4105GSA Flagellar export protein flij GD372_07935 ENOG4108JIR Flagellum-specific ATP synthase GD372_07940 ENOG41090PJ Flagellar assembly protein GD372_07945 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GD372_07950 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GD372_07955 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GD372_07980 ENOG4105DHT Metal Dependent Phosphohydrolase GD372_07985 ENOG4108T5G Adenylate GD372_08005 ENOG4105MQ3 flagellar protein FliS GD372_08010 ENOG4105DTS flagellar hook-associated GD372_08015 ENOG4105I03 Flagellin GD372_08020 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD372_08025 ENOG4108M9K flagella biosynthesis protein FliZ GD372_08030 ENOG4105K6H D-cysteine desulfhydrase GD372_08035 ENOG4105EAB amino acid AbC transporter GD372_08040 ENOG4105E5Q amino acid AbC transporter GD372_08045 ENOG4105CDA abc transporter atp-binding protein GD372_08060 ENOG4105C26 Dehydrogenase GD372_08070 ENOG4105CK7 Sodium proline symporter GD372_08085 ENOG4105DBE peroxidase GD372_08100 ENOG4105C85 amino acid GD372_08110 ENOG4108T1M outer membrane protein x GD372_08125 ENOG4105RA2 Membrane GD372_08130 ENOG4105XVG cytoplasmic protein GD372_08135 ENOG4105WH1 Two component transcriptional regulator luxr family GD372_08200 ENOG4108WC9 type VI secretion system effector, hcp1 family GD372_08280 ENOG4105FDP GntR family transcriptional regulator GD372_08290 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GD372_08305 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GD372_08310 ENOG4108IJ9 (ABC) transporter GD372_08385 ENOG4107ZSV Receptor GD372_08390 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GD372_08410 ENOG4105C0W non-ribosomal peptide synthetase GD372_08425 ENOG4105BZ1 (ABC) transporter GD372_08430 ENOG4105EYM Major Facilitator superfamily GD372_08450 ENOG4108MQF Chaperone GD372_08460 ENOG4105CW0 outer membrane usher protein GD372_08475 ENOG4105BZU Histidine kinase GD372_08480 ENOG4108Q9V regulatoR GD372_08485 ENOG4105CYC Transferase GD372_08490 ENOG4105DJG MaoC domain protein dehydratase GD372_08515 ENOG4107RGD Major Facilitator superfamily GD372_08530 ENOG4106MMI NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GD372_08535 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GD372_08540 ENOG4105C85 amino acid GD372_08545 ENOG4105MVE transcriptional regulator GD372_08555 ENOG4105CSV Glutaminase GD372_08565 ENOG4107SJW iron permease, FTR1 GD372_08580 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GD372_08590 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GD372_08610 ENOG4105H1N peptidase, M24 GD372_08615 ENOG4108TUY outer membrane protein PgaA GD372_08620 ENOG4107BJW polysaccharide deacetylase GD372_08625 ENOG4105CND Glycosyl transferase, family 2 GD372_08630 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD GD372_08645 ENOG4105D5M phosphate starvation-inducible protein GD372_08650 ENOG4105EWV Sodium calcium exchanger membrane region GD372_08655 ENOG4105BZU Histidine kinase GD372_08665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GD372_08725 ENOG4105CZE histidine utilization repressor GD372_08730 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GD372_08735 ENOG41090B9 response to stress GD372_08750 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GD372_08820 ENOG4108WF3 methyltransferase GD372_08860 ENOG4105GR3 Histidine kinase GD372_08870 ENOG4105ENX hydrolase GD372_08915 ENOG4105C3G gtp-binding protein GD372_08925 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria GD372_08930 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GD372_08955 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GD372_08960 ENOG4108YY7 Invasion gene expression up-regulator SirB GD372_08965 ENOG41063JG Transcriptional regulator GD372_08975 ENOG4105CHH sulfate transporter GD372_09000 ENOG4105EG2 ABC transporter, permease GD372_09005 ENOG4105F38 ABC transporter, permease GD372_09035 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GD372_09040 ENOG4105E2R ROK family GD372_09055 ENOG4107XHZ cytoplasmic chaperone TorD family protein GD372_09060 ENOG4105F3T (LipO)protein GD372_09070 ENOG4105D9U N-acetyltransferase GD372_09080 ENOG4105CJR Integral membrane protein (MviN GD372_09100 ENOG4106ZCM YecM protein GD372_09120 ENOG4105WJG Glutathione GD372_09125 ENOG41081XQ Conserved Protein GD372_09135 ENOG4108TIT dATP pyrophosphohydrolase GD372_09165 ENOG4105FAV ABC, transporter GD372_09175 ENOG4105NXV High-affinity zinc uptake system protein GD372_09180 ENOG4105DR5 peptidase GD372_09185 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase GD372_09195 ENOG4105CA9 Pyruvate kinase GD372_09200 ENOG4106KNT transcriptional regulator GD372_09205 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GD372_09215 ENOG4108UHU Aldolase GD372_09230 ENOG4105M4H endoribonuclease L-psp GD372_09235 ENOG4105DVT helicase GD372_09240 ENOG41072GX Peptidase M22 Glycoprotease GD372_09245 ENOG4105Y4Z Outer Membrane Lipoprotein GD372_09255 ENOG4105CEY Amp-dependent synthetase and ligase GD372_09260 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GD372_09265 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) GD372_09270 ENOG4107QMS site-determining protein GD372_09285 ENOG4105CVE Lytic murein transglycosylase GD372_09290 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GD372_09300 ENOG4107R08 Integrase GD372_09325 ENOG4105NY2 NinB protein GD372_09335 ENOG4105HRS Antitermination protein GD372_09550 ENOG4105UZW Tail fiber assembly protein GD372_09570 ENOG4105C3J Cysteine desulfurase GD372_09605 ENOG4105ED1 spovr family GD372_09615 ENOG4105CNH Multidrug resistance protein MdtL GD372_09620 ENOG4105EUB pirin domain protein GD372_09625 ENOG4105HEI LysR family (Transcriptional regulator GD372_09640 ENOG4105CYN Serine protein kinase GD372_09650 ENOG4105GNX MltA-interacting MipA family protein GD372_09655 ENOG4105DSB aldose 1-epimerase GD372_09670 ENOG4105VUT cytoplasmic protein GD372_09675 ENOG4108RWI nicotinamidase GD372_09680 ENOG4105HDK L-asparaginase GD372_09685 ENOG4105D07 Signal peptide peptidase, SppA GD372_09690 ENOG41069NU Nitroreductase GD372_09695 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GD372_09700 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GD372_09705 ENOG4105MTM Protein of unknown function (DUF1496) GD372_09710 ENOG4105M6F mutator MutT protein GD372_09715 ENOG4105CGK Exodeoxyribonuclease III GD372_09720 ENOG4105SKE transcriptional Regulator LysR family GD372_09750 ENOG4105CIY formyltetrahydrofolate deformylase GD372_09760 ENOG4105I93 response regulator GD372_09765 ENOG4105C6Y Udp-glucose 6-dehydrogenase GD372_09775 ENOG4107104 thymidine kinase GD372_09795 ENOG4108EKI Dehydrogenase GD372_09805 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GD372_09810 ENOG4107QSI ABC, transporter GD372_09820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GD372_09825 ENOG4105C3U ABC transporter GD372_09830 ENOG4108JQ7 (ABC) transporter GD372_09855 ENOG4108T1M outer membrane protein x GD372_09870 ENOG4105K9H YciI-like protein GD372_09875 ENOG410822N TonB family GD372_09885 ENOG4105NAU thioesterase Superfamily protein GD372_09920 ENOG4105EIF outer membrane protein W GD372_09940 ENOG4105DK0 Indole-3-glycerol phosphate synthase GD372_09950 ENOG4105DDQ anthranilate synthase GD372_09970 ENOG4105DB7 PHP domain protein GD372_09975 ENOG4107RTD sua5 ycio yrdc ywlc family protein GD372_09980 ENOG4105FE9 pseudouridine synthase GD372_09985 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GD372_09990 ENOG4105UBK short-chain dehydrogenase reductase GD372_09995 ENOG4105ERU peptidase GD372_10000 ENOG4105RKX Protein of unknown function (DUF2498) GD372_10010 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GD372_10015 ENOG4107R11 Transcriptional regulator GD372_10025 ENOG4107QM5 aconitate hydratase GD372_10030 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GD372_10035 ENOG4105EYK Phosphatidylglycerophosphatase B GD372_10040 ENOG4105Q4A inner membrane protein yciS GD372_10045 ENOG4105CFV Tetratricopeptide repeat protein GD372_10060 ENOG4108ZJT translation initiation factor, Sui1 GD372_10065 ENOG41061RM osmotically inducible lipoprotein GD372_10070 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GD372_10080 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GD372_10085 ENOG4105VCD cytoplasmic protein GD372_10090 ENOG4105D22 carbon starvation protein GD372_10100 ENOG4105CSP Major Facilitator Superfamily GD372_10105 ENOG4105EXW epimerase dehydratase GD372_10110 ENOG4105CSM endonuclease III GD372_10120 ENOG4108UQQ Electron transport complex GD372_10125 ENOG4105D6A Electron transport complex GD372_10130 ENOG4105UEI Transcriptional Regulator AraC Family GD372_10150 ENOG4105M9B inner membrane protein ydgK GD372_10165 ENOG4105C42 Type I secretion membrane fusion protein (HlyD GD372_10170 ENOG4108JJA ABC, transporter GD372_10185 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator GD372_10195 ENOG4105CNN ABC, transporter GD372_10205 ENOG4105D9R oxidoreductase GD372_10210 ENOG4105DHU Bile acid GD372_10220 ENOG4106J39 exported protein GD372_10225 ENOG4105EIP mannose-6-phosphate isomerase GD372_10230 ENOG4105C9Q fumarate hydratase class II GD372_10235 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) GD372_10245 ENOG4106NZI LysR family Transcriptional regulator GD372_10250 ENOG4105DAG ROK family GD372_10255 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GD372_10260 ENOG4105CMQ Chloride channel GD372_10270 ENOG41060NJ transcriptional regulator GD372_10285 ENOG4107UWC ABC, transporter GD372_10290 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GD372_10300 ENOG4105FYV Amp nucleosidase GD372_10330 ENOG4105C7K acetolactate synthase GD372_10335 ENOG4105M71 acetolactate synthase 1 regulatory subunit GD372_10340 ENOG4105PAD Hydrolase GD372_10355 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GD372_10360 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GD372_10365 ENOG4105Q9Y Universal stress protein GD372_10370 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GD372_10375 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GD372_10385 ENOG4105C5D exported protein GD372_10390 ENOG4105D5Q Arginine ornithine antiporter GD372_10400 ENOG4107EXC regulatoR GD372_10405 ENOG4105JJR Histidine kinase GD372_10410 ENOG4105CTD carboxy-peptidase GD372_10435 ENOG4105DS1 cytochrome b561 GD372_10450 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap GD372_10465 ENOG4105CQ7 ATP-dependent helicase GD372_10475 ENOG4105DKT Transcriptional regulator GD372_10480 ENOG4105DEI Mannitol dehydrogenase GD372_10485 ENOG4105WXT Conserved Protein GD372_10490 ENOG410689M (LipO)protein GD372_10495 ENOG4107H52 Dicarboxylate transport GD372_10500 ENOG4105C5I Dehydrogenase GD372_10505 ENOG41090X5 Heat shock protein hslJ GD372_10515 ENOG4105KT7 mgtC SapB transporter GD372_10525 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) GD372_10555 ENOG4107QSI ABC, transporter GD372_10560 ENOG4105KXI murein peptide amidase A GD372_10565 ENOG4107S8C mandelate racemase muconate lactonizing GD372_10570 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GD372_10575 ENOG4108RS6 transposase GD372_10600 ENOG4105CM6 amino acid regulated cytosolic protein GD372_10610 ENOG4105FM1 phage shock protein C GD372_10615 ENOG4105YYT phage shock protein B GD372_10620 ENOG41087YS Phage shock protein A GD372_10625 ENOG4105E51 psp operon transcriptional activator GD372_10640 ENOG4108HIY periplasmic GD372_10645 ENOG4108I5W peptide transport system, permease protein GD372_10650 ENOG4108EU3 peptide transport system, permease GD372_10655 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GD372_10660 ENOG4108JQ2 peptide transport system atp-binding protein GD372_10665 ENOG4105Q4T oxidoreductase GD372_10670 ENOG4105DUX Transporter GD372_10675 ENOG41069YE inner membrane protein yohC GD372_10680 ENOG4108ZR5 Conserved Protein GD372_10685 ENOG4108K3A Glutathione S-transferase GD372_10705 ENOG410642K Lysozyme inhibitor GD372_10715 ENOG4108XTF Outer Membrane Lipoprotein GD372_10720 ENOG4108RS6 transposase GD372_10735 ENOG4107RGM aldo keto reductase GD372_10740 ENOG4105XZD Fe-S protein GD372_10745 ENOG4105DIJ Phosphoethanolamine transferase GD372_10750 ENOG4108WUH Transcriptional regulator, TetR family GD372_10755 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GD372_10765 ENOG4108UYE Lactoylglutathione lyase GD372_10770 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) GD372_10780 ENOG4105M2J Glutaredoxin GD372_10790 ENOG4105K4H Nlp p60 protein GD372_10795 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GD372_10810 ENOG4105F52 Transcriptional regulator GD372_10815 ENOG4105CZQ inner membrane transport protein YdhC GD372_10825 ENOG4108R6K riboflavin synthase, subunit alpha GD372_10850 ENOG4105CA9 Pyruvate kinase GD372_10855 ENOG4105KMX major outer membrane lipoprotein GD372_10875 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GD372_10890 ENOG4105JRK feS assembly protein SufD GD372_10895 ENOG4105C3K feS assembly ATPase SufC GD372_10900 ENOG4105DIW FeS assembly protein SUFB GD372_10905 ENOG4108Z4V iron-sulfur cluster assembly GD372_10915 ENOG4105KA0 thioesterase Superfamily protein GD372_10920 ENOG4105CQB FAD linked oxidase domain protein GD372_10925 ENOG4105IPI Membrane GD372_10935 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GD372_10945 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GD372_10960 ENOG4108QBX (LipO)protein GD372_11005 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) GD372_11010 ENOG4108V06 Glutathione peroxidase GD372_11025 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GD372_11030 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GD372_11035 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GD372_11065 ENOG41087WU GD372_11090 ENOG4105DSE periplasmic solute binding protein GD372_11095 ENOG4105DIK (ABC) transporter GD372_11100 ENOG4105CC5 ABC transporter GD372_11105 ENOG4105CC5 ABC transporter GD372_11115 ENOG4105FGM Fructosamine kinase GD372_11120 ENOG4107PN8 YfeABCD locus regulator GD372_11125 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 GD372_11145 ENOG4105CJB Exodeoxyribonuclease I GD372_11155 ENOG4105CUB amino acid GD372_11165 ENOG4107SCQ Iron-containing alcohol dehydrogenase GD372_11170 ENOG4105C2J ABC transporter GD372_11175 ENOG4105C2J ABC transporter GD372_11180 ENOG4105CNN ABC, transporter GD372_11185 ENOG4108535 NAD dependent epimerase/dehydratase family GD372_11200 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GD372_11210 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GD372_11215 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GD372_11230 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GD372_11235 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GD372_11240 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GD372_11245 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GD372_11250 ENOG4105DUU IucA IucC family protein GD372_11255 ENOG4105CNM Receptor GD372_11260 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GD372_11265 ENOG4105DQ5 transport system permease protein GD372_11270 ENOG4105TVJ transport system, permease GD372_11275 ENOG4105E0A ABC, transporter GD372_11280 ENOG4105DUU IucA IucC family protein GD372_11290 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GD372_11295 ENOG4105DY8 decarboxylase GD372_11300 ENOG4108819 ferric iron reductase GD372_11305 ENOG4105EE5 Membrane protein terC GD372_11310 ENOG4108GAE asmA family GD372_11325 ENOG4105D1F ATP-binding protein GD372_11335 ENOG4108RS6 transposase GD372_11355 ENOG4105E5W Transporter GD372_11365 ENOG41067MG lrgb family GD372_11380 ENOG4107GZ4 SanA protein GD372_11385 ENOG4108HWV )-transporter GD372_11400 ENOG4105DHF Membrane GD372_11410 ENOG4105CBP Major Facilitator GD372_11415 ENOG4105EGI Transcriptional regulator GD372_11440 ENOG4105ENT Efflux transporter rnd family, mfp subunit GD372_11445 ENOG4105C19 ABC transporter GD372_11455 ENOG4105CVM Molybdenum cofactor synthesis domain protein GD372_11460 ENOG4105D06 uba thif-type nad fad binding protein GD372_11475 ENOG4105C5H ABC transporter GD372_11570 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GD372_11580 ENOG4105CDV Ompa motb domain protein GD372_11605 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GD372_11610 ENOG41062T2 Acyl carrier protein GD372_11620 ENOG4105CHR reductase GD372_11625 ENOG4108KQ6 Enoyl-CoA hydratase GD372_11635 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase GD372_11640 ENOG4105CHR reductase GD372_11645 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GD372_11650 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GD372_11685 ENOG4108Z0T Part of a sulfur-relay system (By similarity) GD372_11705 ENOG4105K4P CoA-binding domain protein GD372_11710 ENOG4108Q67 UPF0319 protein GD372_11720 ENOG41088T4 Helicase IV GD372_11725 ENOG410901E Membrane GD372_11730 ENOG4105EM2 membrane GD372_11735 ENOG4108RZ1 DNA transformation protein GD372_11745 ENOG4105UYK outer membrane protein a GD372_11750 ENOG4108RS6 transposase GD372_11760 ENOG4105DAN ATP-dependent protease GD372_11795 ENOG4108RS6 transposase GD372_11800 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) GD372_11810 ENOG4108Q2G (LipO)protein GD372_11820 ENOG4105DY2 Paraquat-inducible protein b GD372_11825 ENOG4105F1S paraquat-inducible protein a GD372_11830 ENOG4105C5H ABC transporter GD372_11840 ENOG4105QVC MOSC domain-containing protein GD372_11845 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GD372_11855 ENOG4105CD8 aminopeptidase N GD372_11875 ENOG4105CGF Aromatic amino acid aminotransferase GD372_11885 ENOG4105C5X domain protein GD372_11890 ENOG4105EAQ (twin-arginine translocation) pathway signal GD372_11895 ENOG4105DIT ErfK YbiS YcfS YnhG family protein GD372_11910 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GD372_11915 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) GD372_11920 ENOG4106371 Methyltransferase GD372_11935 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups GD372_11950 ENOG4105W49 UPF0434 protein GD372_11955 ENOG4105VEQ Cold shock protein GD372_11965 ENOG4105E32 cytoplasmic protein GD372_11980 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GD372_11995 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GD372_12020 ENOG4105EUR Domain-Containing protein GD372_12020 ENOG4105EUR Domain-Containing protein GD372_12025 ENOG4105HDK L-asparaginase GD372_12030 ENOG4105DDY UPF0142 protein ycaO GD372_12035 ENOG4105TMB Formate nitrite transporter GD372_12040 ENOG4105C6N Formate acetyltransferase GD372_12050 ENOG4105F1A Pyruvate formate-lyase GD372_12055 ENOG4108ISG Major Facilitator GD372_12065 ENOG4105D1H recombination factor protein RarA GD372_12075 ENOG4105CNU cell division protein FtsK GD372_12080 ENOG4105EW9 transcriptional regulator AsnC family GD372_12085 ENOG4105C3M thioredoxin reductase GD372_12090 ENOG4108JJ9 ABC, transporter GD372_12095 ENOG4108JJ8 (ABC) transporter GD372_12105 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GD372_12120 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GD372_12135 ENOG4105VEQ Cold shock protein GD372_12145 ENOG4105DJY efflux transporter, rnd family, mfp subunit GD372_12150 ENOG4108MJ5 VirK protein GD372_12155 ENOG4105CPB ATP-dependent endonuclease of the OLD family GD372_12160 ENOG4105DWU Membrane GD372_12170 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GD372_12175 ENOG4105C7K acetolactate synthase GD372_12185 ENOG4105C5W Aldolase GD372_12190 ENOG4105CGD Nad-dependent epimerase dehydratase GD372_12195 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GD372_12200 ENOG41064MM (LipO)protein GD372_12205 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) GD372_12210 ENOG4105E5Z arginine transporter ATP-binding subunit GD372_12215 ENOG4106PMH Extracellular solute-binding protein family 3 GD372_12220 ENOG4105GBT ABC transporter GD372_12225 ENOG4105DMR ABC, transporter GD372_12230 ENOG4108I0N Transporter, RarD family, DMT superfamily protein GD372_12235 ENOG4108MRU Uncharacterized protein conserved in bacteria (DUF2338) GD372_12240 ENOG410642S Nicotianamine synthase protein GD372_12245 ENOG4105E0A ABC, transporter GD372_12250 ENOG4105DQ5 transport system permease protein GD372_12255 ENOG4105EHG Permease protein GD372_12280 ENOG4106TNF Periplasmic binding protein GD372_12290 ENOG4105RBQ inner membrane protein ybjO GD372_12295 ENOG4105D38 putrescine abc transporter GD372_12300 ENOG4105F38 ABC transporter, permease GD372_12340 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GD372_12350 ENOG4105EUR Domain-Containing protein GD372_12360 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GD372_12370 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) GD372_12375 ENOG4108VYJ response regulator receiver protein GD372_12385 ENOG4105BZU Histidine kinase GD372_12390 ENOG4105C8Q Methyl-accepting chemotaxis GD372_12395 ENOG4105C8Q Methyl-accepting chemotaxis GD372_12415 ENOG4105WWK YheO domain protein GD372_12425 ENOG4105KME endoribonuclease L-psp GD372_12430 ENOG4105R9B Major Facilitator GD372_12435 ENOG4108V3W Chemotaxis protein, CheW GD372_12440 ENOG4105CBS Chea signal transduction histidine kinase GD372_12445 ENOG4105ER2 Ompa motb domain protein GD372_12450 ENOG4107RD7 Flagellar Motor Protein, MotA GD372_12455 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region GD372_12465 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GD372_12470 ENOG4105KT7 mgtC SapB transporter GD372_12485 ENOG4105VEQ Cold shock protein GD372_12500 ENOG4105GSJ Inner membrane protein ylaC GD372_12505 ENOG4108XM1 transcriptional regulator AsnC family GD372_12515 ENOG41061EV selenium-binding protein YdfZ GD372_12520 ENOG4105D6F Phosphatase GD372_12525 ENOG4105KVH Transcriptional regulator GD372_12530 ENOG4105ECR NmrA family GD372_12535 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GD372_12545 ENOG4106NDP Transcriptional regulator GD372_12550 ENOG4108HMX isocitrate dehydrogenase (NADP) GD372_12555 ENOG4108R99 pseudouridine synthase GD372_12575 ENOG4107QTF adenylosuccinate lyase GD372_12585 ENOG4105XJC Two component transcriptional regulator (Winged helix family GD372_12595 ENOG4105EZE Cupin 4 family protein GD372_12610 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GD372_12625 ENOG4105D60 lipoprotein releasing system transmembrane protein GD372_12635 ENOG4105D60 lipoprotein releasing system transmembrane protein GD372_12640 ENOG4108JA2 transcriptioN-repair coupling factor GD372_12645 ENOG4107MBR 17 kDa surface antigen GD372_12675 ENOG4105CEP NADH dehydrogenase GD372_12685 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GD372_12700 ENOG41090DQ Lipoprotein GD372_12705 ENOG4105K59 histidine triad (HIT) protein GD372_12710 ENOG4105F9E Shikimate 5-dehydrogenase GD372_12720 ENOG4105CI1 PTS System GD372_12725 ENOG4105F8V Hydrolase, tatD family GD372_12730 ENOG4107QRG dna polymerase iii GD372_12740 ENOG4105HHA aminodeoxychorismate lyase GD372_12745 ENOG4105YAZ 4-amino-4-deoxychorismate lyase GD372_12755 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GD372_12765 ENOG4105CHR reductase GD372_12770 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GD372_12785 ENOG4105VGS 50s ribosomal protein l32 GD372_12790 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GD372_12800 ENOG4105EI2 Pseudouridine synthase GD372_12805 ENOG4107QQB Ribonuclease E GD372_12820 ENOG41067V3 Antibiotic biosynthesis monooxygenase GD372_12840 ENOG4105PVA Biofilm formation regulatory protein BssS GD372_12865 ENOG4105DSF transport protein GD372_12885 ENOG4107YC3 synthase GD372_12890 ENOG4105VJY transcriptional regulator GD372_12895 ENOG4105ETT transcriptional Regulator, LysR family GD372_12905 ENOG4105C54 Major Facilitator superfamily GD372_12915 ENOG4105CPC Aldo Keto reductase GD372_12920 ENOG4108Y1S CRISPR-associated protein, Csy4 family GD372_12925 ENOG4105M6W Crispr-associated protein, Csy3 family GD372_12930 ENOG4105DZX CRISPR-associated protein, Csy2 family GD372_12935 ENOG4105ENG CRISPR-associated protein, Csy1 family GD372_12940 ENOG4107IIZ CRISPR-associated helicase, Cas3 GD372_12945 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GD372_12950 ENOG4105CUY Mechanosensitive ion channel GD372_12970 ENOG4105HY2 Glycosidase related protein GD372_12975 ENOG4105DRS transport system, permease GD372_12990 ENOG4105ETE Transcriptional regulator (LacI family GD372_13000 ENOG4108IJ9 (ABC) transporter GD372_13010 ENOG4105CKT filamentous hemagglutinin GD372_13015 ENOG4105CKT filamentous hemagglutinin GD372_13035 ENOG4105CKT filamentous hemagglutinin GD372_13055 ENOG4105CKT filamentous hemagglutinin GD372_13060 ENOG4105D5K Hemolysin activator protein GD372_13065 ENOG4105E3J oxidoreductase GD372_13070 ENOG4105DVW rieske (2Fe-2S) GD372_13075 ENOG4105C94 Transporter GD372_13085 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GD372_13090 ENOG4105EJC lysr family transcriptional regulator GD372_13095 ENOG4105FKQ transcriptional regulator GD372_13100 ENOG4105CNN ABC, transporter GD372_13105 ENOG4105C2J ABC transporter GD372_13110 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GD372_13115 ENOG4105CPQ Dehydrogenase GD372_13135 ENOG4108T1M outer membrane protein x GD372_13165 ENOG4107R0W ABC transporter GD372_13170 ENOG4105E5Q amino acid AbC transporter GD372_13175 ENOG4105CDA abc transporter atp-binding protein GD372_13180 ENOG4107SDU Methyl-accepting chemotaxis GD372_13210 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction GD372_13220 ENOG4108MTB glycosyl transferase family GD372_13225 ENOG4105CEY Amp-dependent synthetase and ligase GD372_13235 ENOG4108IPT Naphthoate synthase GD372_13250 ENOG4105E4F Isochorismate synthase GD372_13260 ENOG4105TNS Conserved Protein GD372_13275 ENOG4105C01 Dihydroxy-acid dehydratase GD372_13290 ENOG4105C5I Dehydrogenase GD372_13295 ENOG4105K2J Transcriptional regulator GD372_13300 ENOG4105F32 YngK protein GD372_13305 ENOG4105CHR reductase GD372_13310 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GD372_13315 ENOG4108R66 Conserved Protein GD372_13330 ENOG4105C8S subunit m GD372_13335 ENOG4105D65 subunit l GD372_13345 ENOG4107UFS subunit j GD372_13360 ENOG4108IEH NADH dehydrogenase subunit g GD372_13365 ENOG4107QIZ NADH dehydrogenase GD372_13370 ENOG4105GKE subunit e GD372_13380 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GD372_13390 ENOG4107NQ8 LysR family Transcriptional regulator GD372_13395 ENOG4105CHM Aminotransferase GD372_13410 ENOG4107QWE )-transporter GD372_13415 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GD372_13435 ENOG4105C6K Malic enzyme GD372_13440 ENOG4107P2S Transcriptional regulator GD372_13475 ENOG4105PTV Nudix Hydrolase GD372_13490 ENOG4105ECP epimerase GD372_13495 ENOG4108JEH abc transporter atp-binding protein GD372_13500 ENOG4106YG3 ABC transporter GD372_13505 ENOG4105DSP amino acid AbC transporter GD372_13510 ENOG4105E89 ABC transporter GD372_13515 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GD372_13520 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GD372_13525 ENOG4105E96 Colicin v production protein GD372_13530 ENOG4108S3P Sporulation domain protein GD372_13535 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GD372_13545 ENOG4105DQR SNARE associated Golgi GD372_13555 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GD372_13570 ENOG410631K Membrane GD372_13575 ENOG4106WZ1 flagella biosynthesis regulator GD372_13590 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GD372_13600 ENOG4105MH2 YfcL protein GD372_13605 ENOG4108BPE -transporting atpase GD372_13610 ENOG4105EJ9 Membrane GD372_13625 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GD372_13640 ENOG4108BY2 phosphohistidine phosphatase GD372_13655 ENOG4105KZW UPF0381 protein GD372_13660 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GD372_13665 ENOG410903C (LipO)protein GD372_13670 ENOG4105KWW Biogenesis protein GD372_13675 ENOG4105KWW Biogenesis protein GD372_13680 ENOG4107QX9 Thiol disulfide interChange protein GD372_13685 ENOG4105DA4 cytochrome c-type biogenesis protein GD372_13695 ENOG4105X3C heme exporter protein GD372_13700 ENOG41060IM Heme exporter protein GD372_13705 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GD372_13725 ENOG4108V0P LemA family GD372_13735 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GD372_13765 ENOG4105CS6 Rhs element vgr protein GD372_13825 ENOG4105CW0 outer membrane usher protein GD372_13840 ENOG4105CW0 outer membrane usher protein GD372_13845 ENOG4105GQR Chaperone GD372_13855 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GD372_13905 ENOG4105CVE Lytic murein transglycosylase GD372_13930 ENOG4108WC9 type VI secretion system effector, hcp1 family GD372_13940 ENOG4107QY8 reductase GD372_13945 ENOG4105QAX Iron-sulfur GD372_13950 ENOG4107KGK dmso reductase anchor subunit GD372_13955 ENOG4108NEM leader-binding protein dmsD GD372_13965 ENOG4107Y60 (LipO)protein GD372_13975 ENOG4106B0W Curli production assembly transport component CsgG GD372_13985 ENOG4108VKM cytochrome b561 GD372_13990 ENOG4105CHM Aminotransferase GD372_13995 ENOG41072TH Protein of unknown function (DUF1479) GD372_14010 ENOG4105C5Q Transcriptional regulator GD372_14015 ENOG4105CPC Aldo Keto reductase GD372_14030 ENOG4105D9N nucleoside GD372_14070 ENOG4108RS6 transposase GD372_14100 ENOG4105VRT cytoplasmic protein GD372_14115 ENOG4105EXN Sulfate transport protein CysZ GD372_14120 ENOG4105C6T cysteine synthase GD372_14125 ENOG4105KZ7 phosphocarrier protein hpr GD372_14135 ENOG4105C5Y PTS System GD372_14145 ENOG4105E0F Histidine kinase GD372_14150 ENOG4105E3W Two component transcriptional regulator (Winged helix family GD372_14155 ENOG4105DJY efflux transporter, rnd family, mfp subunit GD372_14170 ENOG4105E1V na solute symporter GD372_14180 ENOG4107RAQ aminopeptidase GD372_14190 ENOG4105C87 Aminotransferase class I and II GD372_14200 ENOG41062D9 Histidine kinase GD372_14205 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD372_14220 ENOG4108IJ6 ABC transporter GD372_14225 ENOG4105ECW sulfate abc transporter GD372_14230 ENOG4108I5D sulfate abc transporter GD372_14235 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein GD372_14245 ENOG4105QEK Transcriptional regulator GD372_14255 ENOG4108R66 Conserved Protein GD372_14280 ENOG4105EZR dyp-type peroxidase family protein GD372_14285 ENOG4105E7K (LipO)protein GD372_14290 ENOG4105H4F exported protein GD372_14325 ENOG4105C6K Malic enzyme GD372_14335 ENOG4105CUW cytochrome C-TYPE protein GD372_14340 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) GD372_14350 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase GD372_14355 ENOG4108ZNS ferredoxin-type protein NapF GD372_14360 ENOG4105WH1 Two component transcriptional regulator luxr family GD372_14370 ENOG4105BZS acriflavin resistance protein GD372_14380 ENOG4105S2T inner membrane protein YbcI GD372_14385 ENOG4105C4X radical SAM domain protein GD372_14390 ENOG4105ENH Sulfatase GD372_14405 ENOG4107Z33 ABC transporter, permease GD372_14410 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC GD372_14420 ENOG4105KUZ arsenate reductase GD372_14455 ENOG4105CGZ zinc metallopeptidase GD372_14470 ENOG4108RS6 transposase GD372_14475 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GD372_14485 ENOG4105RH4 Glycine cleavage system transcriptional repressor GD372_14490 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GD372_14505 ENOG4105C02 permease GD372_14510 ENOG4105ERG peptidase m48, ste24p GD372_14515 ENOG4105K89 arsenate reductase GD372_14525 ENOG4108RS6 transposase GD372_14540 ENOG4108V3E phosphoribosylglycinamide formyltransferase GD372_14545 ENOG4108MK9 spermidine N(1)-acetyltransferase GD372_14560 ENOG4105E2Z phosphate ABC transporter (Permease GD372_14565 ENOG4105C8U phosphate abc transporter GD372_14570 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GD372_14575 ENOG4105C9X ppx gppa phosphatase GD372_14585 ENOG4105CJW magnesium transporter GD372_14590 ENOG4105R8A Heat shock protein GD372_14595 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component GD372_14600 ENOG4105F38 ABC transporter, permease GD372_14610 ENOG4108JPW Aminotransferase GD372_14620 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GD372_14650 ENOG4105E3W Two component transcriptional regulator (Winged helix family GD372_14655 ENOG4105KWI UPF0339 protein GD372_14660 ENOG4105CFP Peptidase U32 GD372_14675 ENOG4108ZGU inhibitor of vertebrate lysozyme GD372_14685 ENOG4105DWF phosphomethylpyrimidine kinase GD372_14730 ENOG4108WC9 type VI secretion system effector, hcp1 family GD372_14740 ENOG4108RS6 transposase GD372_14750 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GD372_14760 ENOG4105VPD cellular component movement GD372_14775 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GD372_14780 ENOG4105N21 Membrane GD372_14825 ENOG4108MGN ATP-binding component of a transport system GD372_14830 ENOG4108MGN ATP-binding component of a transport system GD372_14845 ENOG4105YYA enhanced serine sensitivity protein SseB GD372_14855 ENOG4105WVQ Fe-S assembly protein IscX GD372_14860 ENOG4108ZIT Ferredoxin, 2FE-2S GD372_14865 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GD372_14885 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GD372_14890 ENOG4105C3J Cysteine desulfurase GD372_14910 ENOG4105D7X high-affinity nickel-transporter GD372_14915 ENOG41065CD Exported protein GD372_14920 ENOG4108MN2 Stationary phase inducible protein CsiE GD372_14925 ENOG4105D8G Major Facilitator superfamily GD372_14940 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GD372_14950 ENOG4108YZA Nitrogen regulatory protein pii GD372_14955 ENOG4105C4K Nad synthetase GD372_14960 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GD372_14965 ENOG4108SKK alpha helix protein GD372_14970 ENOG4107WP9 Histidine kinase GD372_15015 ENOG4108Z6B deaminase GD372_15020 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB GD372_15030 ENOG4106G6Q Transcriptional regulator GD372_15035 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GD372_15040 ENOG4108RS6 transposase GD372_15050 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GD372_15070 ENOG4105C3F Signal peptidase i GD372_15085 ENOG4105WMJ Positive regulator of sigma E, RseC MucC GD372_15090 ENOG4105VQK sigma E regulatory protein, MucB RseB GD372_15095 ENOG41069PW sigma-e factor negative regulatory protein GD372_15105 ENOG4108IYU L-aspartate oxidase GD372_15115 ENOG4105C1J atp-dependent rna helicase GD372_15165 ENOG4107R7A Allophanate hydrolase subunit 2 GD372_15175 ENOG4107QNR UPF0135 protein GD372_15180 ENOG4107RF4 Phosphodiesterase GD372_15185 ENOG4105CVP deoxyribo-dipyrimidine photolyase GD372_15190 ENOG4107SEY Conserved Protein GD372_15200 ENOG4105XIQ Protein of unknown function (DUF2517) GD372_15230 ENOG4105C08 Histidine kinase GD372_15235 ENOG4105EEX Two component transcriptional regulator (Winged helix family GD372_15250 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GD372_15275 ENOG4105EZV Transcriptional regulator GD372_15280 ENOG4105VCP PTS System GD372_15285 ENOG4105CK1 PTS System GD372_15290 ENOG4105VZJ PTS System GD372_15300 ENOG41085Q9 Protein CrcB homolog GD372_15305 ENOG41086WQ Protein CrcB homolog GD372_15310 ENOG4107SVH Potassium channel protein GD372_15315 ENOG4105XXV Acid-resistance protein GD372_15335 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GD372_15365 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) GD372_15370 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GD372_15375 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GD372_15380 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GD372_15385 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GD372_15390 ENOG4105VEQ Cold shock protein GD372_15400 ENOG4108SAJ Protein of unknown function (DUF1198) GD372_15405 ENOG4108WMJ Protein of unknown function (DUF2002) GD372_15430 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GD372_15435 ENOG4108IJ7 Glycine betaine GD372_15440 ENOG4108HQS Glycine betaine GD372_15445 ENOG4105GIJ Glycine betaine GD372_15485 ENOG4105EV9 Alpha Beta Hydrolase GD372_15490 ENOG4105NNH LexA regulated protein GD372_15500 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GD372_15505 ENOG41090R7 Ferric uptake GD372_15530 ENOG4108RS6 transposase GD372_15535 ENOG4105CI1 PTS System GD372_15545 ENOG4105CE4 GlcNAc 6-P deacetylase GD372_15550 ENOG4105E2R ROK family GD372_15555 ENOG4105D4U had-superfamily hydrolase, subfamily iia GD372_15560 ENOG4105CAQ asparagine synthetase GD372_15600 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GD372_15610 ENOG4105C9A Phoh family GD372_15620 ENOG4108JU5 Magnesium and cobalt efflux protein GD372_15625 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GD372_15630 ENOG4107RP9 extracellular solute-binding protein, family 3 GD372_15635 ENOG4105EAD ABC transporter GD372_15640 ENOG4105DRP amino acid AbC transporter GD372_15645 ENOG4105CDA abc transporter atp-binding protein GD372_15650 ENOG4107PAI alpha helical protein GD372_15665 ENOG4105DJF DNA polymerase III, delta' subunit GD372_15675 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GD372_15685 ENOG4105CJN penicillin-binding protein GD372_15690 ENOG4105CNI cell division protein FtsW GD372_15695 ENOG4105K6T rare lipoprotein A GD372_15700 ENOG4105DZ1 carboxypeptidase GD372_15725 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) GD372_15730 ENOG4107Z6W Protein CrcB homolog GD372_15735 ENOG4105VEQ Cold shock protein GD372_15745 ENOG4108N8T regulatoR GD372_15770 ENOG4108JJ7 ABC transporter GD372_15780 ENOG4105DH8 myo-inositol catabolism GD372_15790 ENOG4105EDK PfkB domain protein GD372_15795 ENOG4105CK5 oxidoreductase GD372_15800 ENOG4105CNN ABC, transporter GD372_15805 ENOG4105C2J ABC transporter GD372_15810 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GD372_15820 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GD372_15825 ENOG4105C26 Dehydrogenase GD372_15840 ENOG4105DN3 alpha-2-macroglobulin domain protein GD372_15845 ENOG4108RS6 transposase GD372_15850 ENOG4108JQB penicillin-binding protein 1C GD372_15855 ENOG4105HVQ Regulatory factor of maltose metabolism GD372_15875 ENOG4108WC9 type VI secretion system effector, hcp1 family GD372_15925 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GD372_15940 ENOG4107SET aldo keto reductase GD372_15945 ENOG4105EQ2 LysR family Transcriptional regulator GD372_15975 ENOG41077RS Phosphatase GD372_15980 ENOG4105E8V Alpha Beta Hydrolase Fold protein GD372_15990 ENOG4108HPI phosphatidate Cytidylyltransferase GD372_15995 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase GD372_16010 ENOG4108KU3 Integrase GD372_16045 ENOG4105WQ3 Rna-binding protein GD372_16050 ENOG4108RS6 transposase GD372_16060 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GD372_16075 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GD372_16080 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GD372_16085 ENOG4105CV6 ABC transporter, permease GD372_16090 ENOG4108I0Y (ABC) transporter GD372_16095 ENOG4108UJV acyl-CoA thioesterase i GD372_16100 ENOG4105E1F short-chain dehydrogenase reductase GD372_16105 ENOG4107QR8 Thioredoxin GD372_16110 ENOG4107QX8 SPFH domain, Band 7 family protein GD372_16115 ENOG4105G5H Membrane GD372_16120 ENOG4108Z6Z Transcriptional regulator GD372_16125 ENOG4105C59 p-type ATPase GD372_16130 ENOG4105MBR gumn family GD372_16135 ENOG4108Z66 YbaK ebsC protein GD372_16150 ENOG4105EU0 Major facilitator Superfamily GD372_16155 ENOG4105CKD glutathione-regulated potassium-efflux system protein GD372_16160 ENOG4107RE1 Inosine-guanosine kinase GD372_16165 ENOG4108QY5 Ferric enterobactin transport protein GD372_16180 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GD372_16185 ENOG4105C30 Nad-dependent epimerase dehydratase GD372_16195 ENOG4108TJN glycosyl transferase group 1 GD372_16230 ENOG4108SMP Nad-dependent epimerase dehydratase GD372_16235 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GD372_16240 ENOG4105FAW cDP-glucose 4,6-dehydratase GD372_16245 ENOG4105FAW cDP-glucose 4,6-dehydratase GD372_16250 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GD372_16255 ENOG4108EX3 reductase GD372_16285 ENOG4107QMP dna polymerase iii subunits gamma and tau GD372_16295 ENOG4105WD1 Membrane GD372_16305 ENOG4106428 Protein of unknown function (DUF2496) GD372_16310 ENOG4105EGS Mechanosensitive ion channel GD372_16315 ENOG41090EX DsrE family GD372_16320 ENOG4108IG5 Transcriptional regulator GD372_16325 ENOG4105C1P efflux transporter, rnd family, mfp subunit GD372_16330 ENOG4105BZS acriflavin resistance protein GD372_16340 ENOG4105YK5 50S ribosomal protein L36 GD372_16350 ENOG4108UKR Biofilm formation regulator YbaJ GD372_16355 ENOG4105KF5 hemolysin expression-modulating protein GD372_16365 ENOG41080UX Methyltransferase GD372_16370 ENOG4108MNP Glycoprotein polysaccharide metabolism GD372_16375 ENOG4105C29 acyl-CoA thioesterase GD372_16380 ENOG4105BZU Histidine kinase GD372_16385 ENOG4108YZA Nitrogen regulatory protein pii GD372_16390 ENOG4105BZ1 (ABC) transporter GD372_16395 ENOG4105BZ1 (ABC) transporter GD372_16400 ENOG4108XM1 transcriptional regulator AsnC family GD372_16405 ENOG4105C6T cysteine synthase GD372_16415 ENOG4108NFA extracellular solute-binding protein GD372_16425 ENOG4108TGP Thioesterase superfamily protein GD372_16430 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GD372_16435 ENOG4105EIN peptidylprolyl cis-trans isomerase GD372_16440 ENOG4105K70 DNA-binding protein GD372_16445 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GD372_16470 ENOG4105M85 Bola protein GD372_16475 ENOG4105IEY (LipO)protein GD372_16480 ENOG4105EYM Major Facilitator superfamily GD372_16485 ENOG4108NFH Sugar hydrolase GD372_16490 ENOG4105E2S oxidase) subunit II GD372_16495 ENOG4105BZ9 Cytochrome C oxidase, subunit I GD372_16500 ENOG4105CCU oxidase (Subunit III) GD372_16505 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) GD372_16515 ENOG4107RDB Major Facilitator GD372_16530 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GD372_16535 ENOG4107S0N DJ-1 family GD372_16550 ENOG4105CTB Polyprenyl synthetase GD372_16565 ENOG4108ZAI phosphatidylglycerophosphatase a GD372_16570 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GD372_16585 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GD372_16610 ENOG4108RS6 transposase GD372_16615 ENOG4108RS6 transposase GD372_16620 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GD372_16625 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GD372_16630 ENOG4105VIE preprotein translocase, subunit YajC GD372_16640 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GD372_16645 ENOG4108ZYK Acyl carrier protein phosphodiesterase GD372_16650 ENOG4105D3R alkyl hydroperoxide reductase GD372_16670 ENOG4105CHR reductase GD372_16680 ENOG4107R28 alpha amylase, catalytic region GD372_16685 ENOG4105C85 amino acid GD372_16690 ENOG4105CWM branched-chain amino acid transport system II carrier protein GD372_16700 ENOG4105BZU Histidine kinase GD372_16705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD372_16710 ENOG4107RH8 nuclease SbcCD subunit D GD372_16715 ENOG4105EYH Exonuclease GD372_16720 ENOG4105DKQ ROK family GD372_16750 ENOG4105F2W methyltransferase GD372_16800 ENOG4108KB2 LysR family Transcriptional regulator GD372_16805 ENOG4105CIN aminoacyl-histidine dipeptidase GD372_16825 ENOG4105CJ2 (LipO)protein GD372_16845 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GD372_16850 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GD372_16855 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GD372_16865 ENOG4105F7V ErfK ybiS ycfS ynhG family protein GD372_16870 ENOG4105E7A Glutamine amidotransferase GD372_16880 ENOG4107QPN acyl-Coa dehydrogenase GD372_16890 ENOG4106YJS accessory processing protein GD372_16915 ENOG4105C5R Aminotransferase GD372_16930 ENOG4105C5R Aminotransferase GD372_16940 ENOG4105E5Q amino acid AbC transporter GD372_16980 ENOG4105EQ0 Major Facilitator superfamily GD372_16985 ENOG4108UMN azlc family GD372_16990 ENOG4105ZED uncharacterized protein ygaH GD372_16995 ENOG4105NTK Transcriptional repressor Mpra GD372_17000 ENOG4105CW7 secretion protein, HlyD family GD372_17005 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD372_17010 ENOG4105EIB trna rrna methyltransferase GD372_17015 ENOG4105K63 Thioredoxin GD372_17020 ENOG4106IUH DTW domain containing protein GD372_17025 ENOG4105CD5 CoA-binding domain protein GD372_17030 ENOG4105JIM Phosphatidylserine synthase GD372_17035 ENOG4105T42 (LipO)protein GD372_17075 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GD372_17080 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GD372_17085 ENOG4105C34 Pseudouridine synthase GD372_17095 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GD372_17100 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GD372_17105 ENOG4108RS6 transposase GD372_17125 ENOG4105C0W non-ribosomal peptide synthetase GD372_17135 ENOG4105C0W non-ribosomal peptide synthetase GD372_17165 ENOG4105BZ1 (ABC) transporter GD372_17180 ENOG4107EFN gluconate transport system permease 3 GD372_17195 ENOG4105CS6 Rhs element vgr protein GD372_17205 ENOG4105CNA YD repeat protein GD372_17220 ENOG41062WK cellular response to acidity GD372_17225 ENOG4105C8P )-transporter GD372_17230 ENOG4105ETE Transcriptional regulator (LacI family GD372_17285 ENOG4107RD7 Flagellar Motor Protein, MotA GD372_17315 ENOG410804A Flagellar hook-associated 2 domain-containing protein GD372_17335 ENOG4108M3R transcriptional activator CadC GD372_17355 ENOG4105E1Q flagellar hook-associated protein GD372_17365 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GD372_17370 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GD372_17375 ENOG4105CGA flagellar basal-body rod protein FlgG GD372_17380 ENOG4108KPB Flagellar basal-body rod protein FlgF GD372_17385 ENOG4105BZE flagellar hook protein, FlgE GD372_17390 ENOG4105W00 Flagellar hook capping protein GD372_17395 ENOG4108ZC9 flagellar basal-body rod protein flgc GD372_17400 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GD372_17405 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA GD372_17425 ENOG4108JIR Flagellum-specific ATP synthase GD372_17440 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GD372_17450 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GD372_17460 ENOG4105DD5 Flagellar motor switch protein GD372_17465 ENOG4105CN7 Flagellar biosynthetic protein FliP GD372_17470 ENOG4105VS8 Flagellar biosynthetic protein fliq GD372_17475 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GD372_17480 ENOG4105D00 flagellar biosynthetic protein flhB GD372_17500 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein GD372_17510 ENOG4106P2F Pfam:Pili_assembly_C GD372_17515 ENOG4106PG1 outer membrane usher protein GD372_17595 ENOG4108ZZF transport protein (ExbD) GD372_17600 ENOG4105CWK Biopolymer transport protein, ExbB GD372_17605 ENOG4105C28 cystathionine GD372_17610 ENOG4108K81 inner membrane protein YghB GD372_17615 ENOG4105CF7 AraC family transcriptional regulator GD372_17620 ENOG4108I6A alcohol dehydrogenase GD372_17630 ENOG4105CV8 reductase GD372_17645 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) GD372_17655 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GD372_17660 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GD372_17670 ENOG4105NF4 modulator of drug activity GD372_17675 ENOG4105CR8 Transcriptional regulator GD372_17680 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GD372_17685 ENOG4105IPS esterase GD372_17690 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GD372_17695 ENOG4108SX3 cytoplasmic protein GD372_17700 ENOG41087AY ADP-Ribose pyrophosphatase GD372_17705 ENOG4105DFG type I secretion outer membrane protein GD372_17720 ENOG4106032 Glutathionylspermidine synthase GD372_17725 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GD372_17735 ENOG4105W0Z cytoplasmic protein GD372_17745 ENOG4105DVH amino acid GD372_17760 ENOG4105I7R Adenylate cyclase GD372_17765 ENOG4106MWK domain protein GD372_17780 ENOG4107ZVW dihydroneopterin aldolase GD372_17800 ENOG4105VCC 30S ribosomal protein S21 GD372_17805 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GD372_17810 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD372_17880 ENOG4105KME endoribonuclease L-psp GD372_17900 ENOG4105CHM Aminotransferase GD372_17920 ENOG4105J12 Multidrug resistance protein mdtN GD372_17925 ENOG4108MI0 Resistance protein GD372_17935 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GD372_17945 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GD372_17955 ENOG4108IJG ABC transporter substrate-binding protein GD372_17960 ENOG4107KJX Transcriptional regulator GD372_17965 ENOG4107T40 Inherit from COG: Glycosyltransferase 36 GD372_17990 ENOG4105CKT filamentous hemagglutinin GD372_17995 ENOG4105CKT filamentous hemagglutinin GD372_18020 ENOG4105CKT filamentous hemagglutinin GD372_18025 ENOG4105D5K Hemolysin activator protein GD372_18030 ENOG4108M24 von Willebrand factor, type A GD372_18045 ENOG4108M24 von Willebrand factor, type A GD372_18065 ENOG4108YK4 Acid-resistance membrane protein GD372_18070 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GD372_18085 ENOG4108VKG metal-dependent hydrolase GD372_18090 ENOG4105EE0 oxidoreductase GD372_18100 ENOG4108RS6 transposase GD372_18105 ENOG4105P66 Membrane GD372_18110 ENOG4105CTX dehydratase GD372_18115 ENOG4107QZW Altronate oxidoreductase GD372_18130 ENOG4105DPW Major facilitator superfamily MFS_1 GD372_18145 ENOG4106W5V Membrane GD372_18165 ENOG4105NE1 Conserved Protein GD372_18170 ENOG41090KG Inner membrane protein YqjE GD372_18180 ENOG4108VBZ doxx family GD372_18200 ENOG4105M6F mutator MutT protein GD372_18230 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GD372_18235 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GD372_18240 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GD372_18260 ENOG4105CNI cell division protein FtsW GD372_18275 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) GD372_18280 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GD372_18285 ENOG4105CJN penicillin-binding protein GD372_18290 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GD372_18310 ENOG4108RNS Exports L-alanine (By similarity) GD372_18315 ENOG4107B7Y DNA-binding transcriptional regulator FruR GD372_18330 ENOG4108ZP8 Acetolactate synthase small subunit GD372_18335 ENOG4105C7K acetolactate synthase GD372_18345 ENOG4108IQE Amp-dependent synthetase and ligase GD372_18355 ENOG41064T2 transcriptional regulator, lysR family GD372_18365 ENOG4108RS6 transposase GD372_18375 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GD372_18390 ENOG4105S8Q sugar efflux transporter GD372_18405 ENOG4105DP9 ABC transporter GD372_18410 ENOG4106SMU thiamine transporter membrane protein GD372_18420 ENOG4108KF1 Membrane GD372_18425 ENOG4105CQ2 DNA polymerase GD372_18480 ENOG4105CS6 Rhs element vgr protein GD372_18485 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GD372_18545 ENOG4105D3G Pseudouridine synthase GD372_18550 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) GD372_18560 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) GD372_18565 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GD372_18595 ENOG4108RS6 transposase GD372_18600 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GD372_18610 ENOG4105DWK Membrane GD372_18615 ENOG4105N14 lysine exporter protein LysE YggA GD372_18620 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GD372_18625 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GD372_18635 ENOG4108RS6 transposase GD372_18645 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GD372_18660 ENOG4105DTN riboflavin biosynthesis protein ribF GD372_18680 ENOG41063Z6 transcriptional regulator, lysR family GD372_18700 ENOG4106HK8 GPR1 FUN34 yaaH family protein GD372_18715 ENOG4108RIR Molybdenum cofactor biosynthesis protein GD372_18765 ENOG41065U4 response regulator GD372_18770 ENOG4108RH0 Crea protein GD372_18780 ENOG4105UEI Transcriptional Regulator AraC Family GD372_18795 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) GD372_18800 ENOG4107SC1 transglycosylase GD372_18815 ENOG4108KHX Diguanylate cyclase GD372_18820 ENOG41090EK ompa motb domain protein GD372_18835 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase GD372_18840 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GD372_18845 ENOG4105EAC phosphoserine phosphatase GD372_18850 ENOG41062Z9 Membrane GD372_18870 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GD372_18875 ENOG4105D9N nucleoside GD372_18880 ENOG4105EYA deoxyribonuclease GD372_18885 ENOG4108NRW Phospholipase, patatin family GD372_18895 ENOG4105K3G Periplasmic Protein GD372_18905 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GD372_18910 ENOG4108WPU DNA polymerase III subunit psi GD372_18925 ENOG4105YBH Protein of unknown function (DUF1435) GD372_18930 ENOG4105BZU Histidine kinase GD372_18955 ENOG4105BZS acriflavin resistance protein GD372_18960 ENOG410624X efflux transporter, rnd family, mfp subunit GD372_18975 ENOG4105DKP glycosyl transferase, family 9 GD372_19025 ENOG4105RI1 glycoprotein receptor GD372_19030 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GD372_19035 ENOG4105DM4 PTS System GD372_19040 ENOG4108YRF PTS System GD372_19045 ENOG4108XCZ PTS System GD372_19050 ENOG4106R3P AraC family transcriptional regulator GD372_19060 ENOG4108M3P Membrane GD372_19120 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 GD372_19140 ENOG4105CWB LysR family transcriptional Regulator GD372_19145 ENOG4108CNN domain protein GD372_19155 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GD372_19175 ENOG4105W4M Transport-associated protein GD372_19185 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain GD372_19195 ENOG4105BZU Histidine kinase GD372_19205 ENOG4105N5T Radical SAM Protein GD372_19210 ENOG4105CBC glutamate synthase GD372_19215 ENOG4105BZ8 glutamate synthase GD372_19225 ENOG4105KB2 stringent starvation protein b GD372_19230 ENOG4107MKT Stringent starvation protein a GD372_19250 ENOG4105D6Z AFG1 family ATPase GD372_19255 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III GD372_19260 ENOG4105C0H protease GD372_19265 ENOG4108RS6 transposase GD372_19270 ENOG4105C0H protease GD372_19280 ENOG4105VFK BolA family GD372_19285 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane GD372_19290 ENOG4105E3I toluene tolerance GD372_19295 ENOG4107PE3 Mammalian cell entry related domain protein GD372_19300 ENOG4105CY3 ABC transporter, permease GD372_19305 ENOG4105DHJ ABC, transporter GD372_19310 ENOG4105FEU K -dependent Na -Ca exchanger GD372_19315 ENOG4105C2X Arabinose 5-phosphate isomerase GD372_19320 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase GD372_19325 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) GD372_19330 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA GD372_19335 ENOG4108IUZ ABC transporter GD372_19340 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD372_19350 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GD372_19365 ENOG41080Z8 PHOSPHOCARRIER protein GD372_19385 ENOG4105KME endoribonuclease L-psp GD372_19395 ENOG4105D4X repressor GD372_19400 ENOG4105C5Y PTS System GD372_19405 ENOG4105CG3 alpha amylase, catalytic region GD372_19410 ENOG4105NXH GreA GreB family elongation factor GD372_19415 ENOG4108XVM Cytochrome b(562) GD372_19425 ENOG4105CMS peptidase U62, modulator of DNA gyrase GD372_19435 ENOG4105UNR (Barnase) inhibitor GD372_19465 ENOG4105CR8 Transcriptional regulator GD372_19515 ENOG4105D1U peptidase U62 modulator of DNA gyrase GD372_19525 ENOG4105QD6 exported protein GD372_19530 ENOG4105C03 ribonuclease GD372_19540 ENOG4105VQ7 Rod shape-determining protein MreD GD372_19545 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GD372_19550 ENOG4105DFF Rod shape-determining protein mreb GD372_19555 ENOG41062P1 Diguanylate cyclase phosphodiesterase GD372_19560 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GD372_19565 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) GD372_19580 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GD372_19585 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GD372_19590 ENOG4105RG0 Membrane GD372_19595 ENOG4108IA2 Sodium pantothenate symporter GD372_19605 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GD372_19610 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) GD372_19635 ENOG4105CSH Transporter GD372_19640 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GD372_19655 ENOG4108XTF Outer Membrane Lipoprotein GD372_19665 ENOG4105VEQ Cold shock protein GD372_19670 ENOG4105VEQ Cold shock protein GD372_19690 ENOG4105CYM Glutathione S-transferase GD372_19695 ENOG4105C2X Arabinose 5-phosphate isomerase GD372_19700 ENOG4105EF1 ribulokinase GD372_19710 ENOG4105CNN ABC, transporter GD372_19715 ENOG4105C2J ABC transporter GD372_19725 ENOG4105D1S lipid A biosynthesis GD372_19735 ENOG4105EEQ Na H antiporter GD372_19740 ENOG4105C7N Xanthine uracil vitamin C permease GD372_19760 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GD372_19770 ENOG4105GVF (ABC) transporter GD372_19780 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GD372_19785 ENOG4108RVA ribokinase GD372_19790 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GD372_19795 ENOG4105W4W Transcriptional regulator GD372_19800 ENOG4107TYG Oxidoreductase domain-containing protein GD372_19820 ENOG4105CNA YD repeat protein GD372_19835 ENOG4105CS6 Rhs element vgr protein GD372_19865 ENOG4105CNA YD repeat protein GD372_19880 ENOG4105CS6 Rhs element vgr protein GD372_19915 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GD372_19975 ENOG4108WC9 type VI secretion system effector, hcp1 family GD372_19985 ENOG4107W52 maltose operon periplasmic protein GD372_20005 ENOG4107FKK extracellular solute-binding protein family 1 GD372_20010 ENOG4105D56 permease protein GD372_20015 ENOG4105EG2 ABC transporter, permease GD372_20030 ENOG4105CFH Aspartokinase GD372_20045 ENOG4105C3R Methionine synthase GD372_20060 ENOG4108I9X Isocitrate lyase GD372_20065 ENOG4107QP3 malate synthase g GD372_20125 ENOG4108Z0R Transferase GD372_20140 ENOG4108WI1 Dna topoisomerase GD372_20150 ENOG4105C79 DNA protecting protein DprA GD372_20170 ENOG4105C1A potassium transporter peripheral membrane GD372_20180 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system GD372_20185 ENOG4105W1Y Transcriptional regulator GD372_20200 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GD372_20215 ENOG41067V7 50S ribosomal protein L36 GD372_20220 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GD372_20230 ENOG4105VPB 50S ribosomal protein L30 GD372_20275 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GD372_20285 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GD372_20290 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GD372_20300 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GD372_20355 ENOG4108RS6 transposase GD372_20370 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GD372_20395 ENOG4105WWK YheO domain protein GD372_20400 ENOG4108V1T peptidylprolyl cis-trans isomerase GD372_20415 ENOG4108YZY peptidylprolyl cis-trans isomerase GD372_20420 ENOG4105VKU nucleicacid-binding protein GD372_20430 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GD372_20440 ENOG4105K64 Glycosyl transferase, family 2 GD372_20450 ENOG4105E2B Taurine dioxygenase GD372_20455 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GD372_20465 ENOG4106FTQ Taurine ABC transporter, periplasmic GD372_20475 ENOG4105DNZ Alpha Beta Hydrolase GD372_20485 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) GD372_20495 ENOG4108UKZ OsmC family GD372_20505 ENOG410613R integral membrane protein, YccS YhfK family GD372_20510 ENOG4105C8Y Acetylornithine aminotransferase GD372_20520 ENOG4105D7A ATP-binding protein GD372_20525 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GD372_20530 ENOG4105F8D glycoside hydrolase family 4 GD372_20535 ENOG41060NJ transcriptional regulator GD372_20550 ENOG4105DZC cytosine deaminase GD372_20555 ENOG4107QZF nitrite reductase NADPH large subunit GD372_20560 ENOG4105WZK nitrite reductase NADPH small subunit GD372_20565 ENOG4107V9H nitrite transporter GD372_20575 ENOG4105C31 Tryptophanyl-tRNA synthetase GD372_20580 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GD372_20585 ENOG4105DJV ribulose-phosphate 3-epimerase GD372_20610 ENOG4105E4G Type IV pilus GD372_20640 ENOG4108JQC penicillin-binding protein 1A GD372_20645 ENOG4107RK2 ADP-ribose diphosphatase NudE GD372_20650 ENOG4105DQY intracellular growth attenuator GD372_20655 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 GD372_20660 ENOG4105VEJ Heat shock protein GD372_20675 ENOG4105E0F Histidine kinase GD372_20680 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD372_20685 ENOG4108RRZ Transcription elongation factor GreB GD372_20690 ENOG4105BZM domain protein GD372_20695 ENOG4105XFK Ferrous iron transport protein A GD372_20700 ENOG4105CE1 Ferrous iron transport protein b GD372_20710 ENOG4105RID UPF0379 protein yhcN GD372_20720 ENOG4105MJ2 Competence protein GD372_20730 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GD372_20735 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GD372_20740 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GD372_20760 ENOG4105E98 transcriptional regulator DeoR family GD372_20775 ENOG4105SYT Methylenetetrahydrofolate reductase GD372_20780 ENOG4105CFH Aspartokinase GD372_20795 ENOG4108Z12 YiaAB two helix domain-containing protein GD372_20805 ENOG4105C25 Primosomal protein n' GD372_20815 ENOG4105ETE Transcriptional regulator (LacI family GD372_20820 ENOG41063M6 Cell Division Protein GD372_20835 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GD372_20860 ENOG4108MBX Secretion Protein GD372_20865 ENOG4108JJA ABC, transporter GD372_20895 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GD372_20900 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GD372_20905 ENOG4105CBT Fructose-1,6-bisphosphatase GD372_20910 ENOG4105DP0 ferredoxin-NADP reductase GD372_20915 ENOG4108VTS Membrane GD372_20920 ENOG4105EBK exported protein GD372_20930 ENOG4107F9Y LysR family transcriptional regulator GD372_20940 ENOG4105JSC dimethylmenaquinone methyltransferase GD372_20945 ENOG4107QPK )-transporter GD372_20955 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GD372_20985 ENOG4105FMW periplasmic GD372_20990 ENOG4105E3W Two component transcriptional regulator (Winged helix family GD372_20995 ENOG4105E0F Histidine kinase GD372_21000 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GD372_21005 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GD372_21010 ENOG4105D7W serine acetyltransferase GD372_21030 ENOG4105VW4 glutaredoxin 3 GD372_21035 ENOG4107YZP Rhodanese domain protein GD372_21045 ENOG41063SB peptidase GD372_21060 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GD372_21070 ENOG4105XA0 heptosyltransferase ii GD372_21075 ENOG4105D16 lipopolysaccharide heptosyltransferase i GD372_21080 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GD372_21100 ENOG4105W0E 50S ribosomal protein L33 GD372_21120 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GD372_21145 ENOG4105DSJ YicC domain protein GD372_21150 ENOG4105EN6 Membrane GD372_21155 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) GD372_21170 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GD372_21175 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GD372_21180 ENOG4105CB5 ATP-dependent DNA helicase recG GD372_21190 ENOG4105D6U Sodium Glutamate Symporter GD372_21195 ENOG4105C2W permease GD372_21200 ENOG4105JV1 AsmA family GD372_21205 ENOG4105SUU thioesterase domain GD372_21225 ENOG4107S2Z UPF0761 membrane protein GD372_21230 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 GD372_21240 ENOG4105C5F glutamine synthetase GD372_21245 ENOG4105CUX Signal transduction histidine kinase GD372_21250 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GD372_21255 ENOG4105D4P Coproporphyrinogen iii oxidase GD372_21280 ENOG4108RS6 transposase GD372_21285 ENOG4105C2M dna polymerase I GD372_21290 ENOG4108Z33 Thiol disulfide Interchange Protein GD372_21295 ENOG4105E27 serine threonine protein kinase GD372_21300 ENOG4105PC1 Conserved Protein GD372_21310 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b GD372_21350 ENOG4107EJG GntR family transcriptional regulator GD372_21355 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD372_21370 ENOG4108RVA ribokinase GD372_21400 ENOG4108VVK transcriptional Regulator, AsnC GD372_21405 ENOG4105QTB Flavodoxin GD372_21425 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation GD372_21435 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GD372_21480 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GD372_21485 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GD372_21490 ENOG4105C8U phosphate abc transporter GD372_21495 ENOG4105E2Z phosphate ABC transporter (Permease GD372_21515 ENOG4106PMH Extracellular solute-binding protein family 3 GD372_21520 ENOG4105EAD ABC transporter GD372_21525 ENOG4105DRP amino acid AbC transporter GD372_21530 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 GD372_21540 ENOG4105C7N Xanthine uracil vitamin C permease GD372_21570 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GD372_21585 ENOG4105VG0 50S ribosomal protein l34 GD372_21600 ENOG4106JVB Replication Protein GD372_21650 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GD372_21660 ENOG4105C2M dna polymerase I GD372_21690 ENOG4106J5W DNA polymerase III (alpha subunit) GD372_21735 ENOG4108D1K outer membrane usher protein GD372_21740 ENOG4108UIF Chaperone GD372_21745 ENOG4106PHM regulatory protein GD372_21785 ENOG4105FEQ ParB domain protein nuclease GD372_21810 ENOG41073YN Protein of unknown function (DUF1380) GD372_21845 ENOG4106RMF ParB family GD372_21895 ENOG4105EKQ RNA-directed DNA polymerase GD372_21910 ENOG4105EQR Transposase IS116 IS110 IS902 GD372_21960 ENOG4105UZW Tail fiber assembly protein GD372_21970 ENOG4108X9F tail fiber protein GD372_21970 ENOG4108X9F tail fiber protein GD372_22005 ENOG4108NYK Tape measure protein GD372_22100 ENOG4105FA0 parb-like partition protein GD372_22105 ENOG4105FA0 parb-like partition protein GD372_22110 ENOG4105CB5 ATP-dependent DNA helicase recG GD372_22200 ENOG4105D2X ABC transporter substrate-binding protein GD372_22220 ENOG4106CQM replication GD372_22485 ENOG4105D5G Transposase GD372_22545 ENOG4105EZN Cobyrinic acid ac-diamide synthase GD372_22550 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB GD372_22625 ENOG4108C33 Resolvase GD372_22630 ENOG4105D13 transposase GD372_22685 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) GD372_22735 ENOG4105VTW prevent-host-death family GD372_22740 ENOG4105KRQ Addiction module toxin, Txe YoeB family GD372_22805 ENOG4107ZQ5 Phage-associated protein, HI1409 family GD372_22810 ENOG4108C66 Inherit from COG: DNA primase GD372_22905 ENOG4108X9F tail fiber protein GD372_22910 ENOG4105UZW Tail fiber assembly protein GD372_22960 ENOG4105XUP Phage derived protein Gp49-like (DUF891)