locus-tag class description GCK68_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GCK68_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GCK68_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GCK68_00025 ENOG410667J hydrolase GCK68_00045 ENOG4105C7B Threonine dehydratase GCK68_00060 ENOG4105R2A (LipO)protein GCK68_00080 ENOG4105JKW Valine--pyruvate aminotransferase GCK68_00100 ENOG4107T9C Alpha amylase catalytic region GCK68_00120 ENOG4108ZG0 Ompa motb domain protein GCK68_00130 ENOG4108R3E Dna-3-methyladenine glycosylase i GCK68_00150 ENOG4106JH6 (LipO)protein GCK68_00155 ENOG4105CTS PTS system mannitol-specific GCK68_00165 ENOG4105E61 Mannitol repressor protein GCK68_00170 ENOG4108YYI Protein of unknown function (DUF2810) GCK68_00185 ENOG4105C8Q Methyl-accepting chemotaxis GCK68_00190 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GCK68_00205 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GCK68_00210 ENOG4108MG3 formate dehydrogenase GCK68_00225 ENOG4105EM7 Selenocysteine-specific translation elongation factor GCK68_00270 ENOG4105MEV Acyl-transferase GCK68_00275 ENOG4106EAR Fimbrial protein GCK68_00285 ENOG4108TTM chaperone GCK68_00295 ENOG4105CMG Carbohydrate kinase GCK68_00305 ENOG4105DFW ABC transporter GCK68_00315 ENOG4107RNG ABC transporter GCK68_00320 ENOG4105T16 Transcriptional regulator (AraC family) GCK68_00330 ENOG4105DFP Integrase GCK68_00340 ENOG4105ZTC transcriptional activator, Ogr delta GCK68_00380 ENOG4108IPW abc transporter atp-binding protein GCK68_00385 ENOG4105CM4 permease protein GCK68_00415 ENOG4105C6T cysteine synthase GCK68_00425 ENOG4105C84 Histidine ammonia-lyase GCK68_00430 ENOG4105C85 amino acid GCK68_00440 ENOG4105DIJ Phosphoethanolamine transferase GCK68_00445 ENOG4108KX4 response regulator GCK68_00465 ENOG4108Z0R Transferase GCK68_00480 ENOG4108WI1 Dna topoisomerase GCK68_00490 ENOG4105C79 DNA protecting protein DprA GCK68_00510 ENOG4105C1A potassium transporter peripheral membrane GCK68_00520 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system GCK68_00525 ENOG4105W1Y Transcriptional regulator GCK68_00540 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GCK68_00555 ENOG41067V7 50S ribosomal protein L36 GCK68_00560 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GCK68_00570 ENOG4105VPB 50S ribosomal protein L30 GCK68_00615 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GCK68_00625 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GCK68_00630 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GCK68_00640 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GCK68_00685 ENOG4108RS6 transposase GCK68_00700 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GCK68_00725 ENOG4105WWK YheO domain protein GCK68_00730 ENOG4108V1T peptidylprolyl cis-trans isomerase GCK68_00745 ENOG4108YZY peptidylprolyl cis-trans isomerase GCK68_00750 ENOG4105VKU nucleicacid-binding protein GCK68_00760 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GCK68_00770 ENOG4105K64 Glycosyl transferase, family 2 GCK68_00780 ENOG4105E2B Taurine dioxygenase GCK68_00785 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GCK68_00795 ENOG4106FTQ Taurine ABC transporter, periplasmic GCK68_00805 ENOG4105DNZ Alpha Beta Hydrolase GCK68_00815 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) GCK68_00825 ENOG4108UKZ OsmC family GCK68_00835 ENOG410613R integral membrane protein, YccS YhfK family GCK68_00840 ENOG4105C8Y Acetylornithine aminotransferase GCK68_00850 ENOG4105D7A ATP-binding protein GCK68_00855 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GCK68_00860 ENOG4105F8D glycoside hydrolase family 4 GCK68_00865 ENOG41060NJ transcriptional regulator GCK68_00880 ENOG4105DZC cytosine deaminase GCK68_00885 ENOG4107QZF nitrite reductase NADPH large subunit GCK68_00890 ENOG4105WZK nitrite reductase NADPH small subunit GCK68_00895 ENOG4107V9H nitrite transporter GCK68_00905 ENOG4105C31 Tryptophanyl-tRNA synthetase GCK68_00910 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GCK68_00915 ENOG4105DJV ribulose-phosphate 3-epimerase GCK68_00940 ENOG4105E4G Type IV pilus GCK68_00970 ENOG4108JQC penicillin-binding protein 1A GCK68_00975 ENOG4107RK2 ADP-ribose diphosphatase NudE GCK68_00980 ENOG4105DQY intracellular growth attenuator GCK68_00985 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 GCK68_00990 ENOG4105VEJ Heat shock protein GCK68_01005 ENOG4105E0F Histidine kinase GCK68_01010 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GCK68_01015 ENOG4108RRZ Transcription elongation factor GreB GCK68_01020 ENOG4105BZM domain protein GCK68_01025 ENOG4105XFK Ferrous iron transport protein A GCK68_01030 ENOG4105CE1 Ferrous iron transport protein b GCK68_01040 ENOG4105RID UPF0379 protein yhcN GCK68_01050 ENOG4105MJ2 Competence protein GCK68_01060 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GCK68_01065 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GCK68_01070 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GCK68_01090 ENOG4105E98 transcriptional regulator DeoR family GCK68_01125 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GCK68_01130 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GCK68_01155 ENOG4108HRK Histidine kinase GCK68_01185 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GCK68_01190 ENOG41076UM multiple antibiotic resistance (MarC)-related protein GCK68_01210 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GCK68_01215 ENOG4105C6Z Gluconate GCK68_01220 ENOG4105DIQ Transcriptional regulator GCK68_01225 ENOG4105C2I pirin domain protein GCK68_01240 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GCK68_01250 ENOG4105D2N Aldolase GCK68_01260 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GCK68_01265 ENOG4105CNN ABC, transporter GCK68_01280 ENOG4105CBX hi0933 family GCK68_01285 ENOG4105CJ3 phosphate transporter GCK68_01290 ENOG4108RS6 transposase GCK68_01300 ENOG4108M6U Universal stress protein A GCK68_01320 ENOG4105DGW oligopeptidase A GCK68_01325 ENOG4105D6S protein involved in catabolism of external DNA GCK68_01330 ENOG4105DC8 reductase GCK68_01335 ENOG4107VHA regulatoR GCK68_01345 ENOG4107QQ0 gntp family GCK68_01350 ENOG4105BZW Glycerate kinase GCK68_01375 ENOG4107H3J ribonuclease GCK68_01380 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) GCK68_01385 ENOG41066T0 asmA family GCK68_01390 ENOG4105CMB EAL domain-containing protein GCK68_01395 ENOG4105VSH 4-oxalocrotonate tautomerase GCK68_01400 ENOG4107SS6 2-dehydro-3-deoxygluconokinase GCK68_01405 ENOG4105CS0 peptidase GCK68_01425 ENOG4108PU9 oligogalacturonate-specific porin GCK68_01430 ENOG4105BZU Histidine kinase GCK68_01435 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) GCK68_01440 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) GCK68_01445 ENOG4108JQ7 (ABC) transporter GCK68_01450 ENOG4105C3U ABC transporter GCK68_01455 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GCK68_01460 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GCK68_01465 ENOG4105DEF Extracellular solute-binding protein, family 5 GCK68_01475 ENOG4105D5K Hemolysin activator protein GCK68_01490 ENOG4105CXY transporter GCK68_01495 ENOG4105BZU Histidine kinase GCK68_01545 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b GCK68_01555 ENOG4105PC1 Conserved Protein GCK68_01560 ENOG4105E27 serine threonine protein kinase GCK68_01565 ENOG4108Z33 Thiol disulfide Interchange Protein GCK68_01570 ENOG4105C2M dna polymerase I GCK68_01575 ENOG4108RS6 transposase GCK68_01580 ENOG4108RS6 transposase GCK68_01605 ENOG4105D4P Coproporphyrinogen iii oxidase GCK68_01610 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GCK68_01615 ENOG4105CUX Signal transduction histidine kinase GCK68_01620 ENOG4105C5F glutamine synthetase GCK68_01630 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 GCK68_01635 ENOG4107S2Z UPF0761 membrane protein GCK68_01655 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 GCK68_01715 ENOG4108M3P Membrane GCK68_01725 ENOG4106R3P AraC family transcriptional regulator GCK68_01730 ENOG4108XCZ PTS System GCK68_01735 ENOG4108YRF PTS System GCK68_01740 ENOG4105DM4 PTS System GCK68_01745 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GCK68_01750 ENOG4105RI1 glycoprotein receptor GCK68_01800 ENOG4105DKP glycosyl transferase, family 9 GCK68_01815 ENOG410624X efflux transporter, rnd family, mfp subunit GCK68_01820 ENOG4105BZS acriflavin resistance protein GCK68_01845 ENOG4105BZU Histidine kinase GCK68_01850 ENOG4105YBH Protein of unknown function (DUF1435) GCK68_01865 ENOG4108WPU DNA polymerase III subunit psi GCK68_01870 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GCK68_01880 ENOG4105K3G Periplasmic Protein GCK68_01890 ENOG4108NRW Phospholipase, patatin family GCK68_01895 ENOG4105EYA deoxyribonuclease GCK68_01900 ENOG4105D9N nucleoside GCK68_01905 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GCK68_01925 ENOG41062Z9 Membrane GCK68_01930 ENOG4105EAC phosphoserine phosphatase GCK68_01935 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GCK68_01940 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase GCK68_01955 ENOG41090EK ompa motb domain protein GCK68_01960 ENOG4108KHX Diguanylate cyclase GCK68_01975 ENOG4107SC1 transglycosylase GCK68_01980 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) GCK68_01995 ENOG4105UEI Transcriptional Regulator AraC Family GCK68_02005 ENOG4108RH0 Crea protein GCK68_02010 ENOG41065U4 response regulator GCK68_02050 ENOG4108RIR Molybdenum cofactor biosynthesis protein GCK68_02065 ENOG4106HK8 GPR1 FUN34 yaaH family protein GCK68_02085 ENOG41063Z6 transcriptional regulator, lysR family GCK68_02105 ENOG4105DTN riboflavin biosynthesis protein ribF GCK68_02120 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GCK68_02130 ENOG4108RS6 transposase GCK68_02140 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GCK68_02155 ENOG4105S8Q sugar efflux transporter GCK68_02170 ENOG4105DP9 ABC transporter GCK68_02175 ENOG4106SMU thiamine transporter membrane protein GCK68_02185 ENOG4108KF1 Membrane GCK68_02190 ENOG4105CQ2 DNA polymerase GCK68_02245 ENOG4105CS6 Rhs element vgr protein GCK68_02250 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GCK68_02295 ENOG4105D3G Pseudouridine synthase GCK68_02300 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) GCK68_02310 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) GCK68_02315 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GCK68_02345 ENOG4108RS6 transposase GCK68_02350 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GCK68_02360 ENOG4105DWK Membrane GCK68_02365 ENOG4105N14 lysine exporter protein LysE YggA GCK68_02370 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GCK68_02375 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GCK68_02385 ENOG4108RS6 transposase GCK68_02395 ENOG41064T2 transcriptional regulator, lysR family GCK68_02405 ENOG4108IQE Amp-dependent synthetase and ligase GCK68_02415 ENOG4105C7K acetolactate synthase GCK68_02420 ENOG4108ZP8 Acetolactate synthase small subunit GCK68_02425 ENOG4108RS6 transposase GCK68_02435 ENOG4107B7Y DNA-binding transcriptional regulator FruR GCK68_02440 ENOG4108RNS Exports L-alanine (By similarity) GCK68_02460 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GCK68_02465 ENOG4105CJN penicillin-binding protein GCK68_02470 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GCK68_02475 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) GCK68_02490 ENOG4105CNI cell division protein FtsW GCK68_02510 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GCK68_02515 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GCK68_02520 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GCK68_02550 ENOG4105M6F mutator MutT protein GCK68_02570 ENOG4108VBZ doxx family GCK68_02580 ENOG41090KG Inner membrane protein YqjE GCK68_02585 ENOG4105NE1 Conserved Protein GCK68_02605 ENOG4106W5V Membrane GCK68_02620 ENOG4105DPW Major facilitator superfamily MFS_1 GCK68_02630 ENOG4107QZW Altronate oxidoreductase GCK68_02635 ENOG4105CTX dehydratase GCK68_02640 ENOG4105P66 Membrane GCK68_02645 ENOG4108RS6 transposase GCK68_02655 ENOG4105EE0 oxidoreductase GCK68_02660 ENOG4108VKG metal-dependent hydrolase GCK68_02675 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GCK68_02680 ENOG4108YK4 Acid-resistance membrane protein GCK68_02700 ENOG4108M24 von Willebrand factor, type A GCK68_02715 ENOG4108M24 von Willebrand factor, type A GCK68_02720 ENOG4105D5K Hemolysin activator protein GCK68_02725 ENOG4105CKT filamentous hemagglutinin GCK68_02750 ENOG4105CKT filamentous hemagglutinin GCK68_02755 ENOG4105CKT filamentous hemagglutinin GCK68_02780 ENOG4107T40 Inherit from COG: Glycosyltransferase 36 GCK68_02785 ENOG4107KJX Transcriptional regulator GCK68_02790 ENOG4108IJG ABC transporter substrate-binding protein GCK68_02800 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GCK68_02810 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GCK68_02820 ENOG4108MI0 Resistance protein GCK68_02825 ENOG4105J12 Multidrug resistance protein mdtN GCK68_02845 ENOG4105CHM Aminotransferase GCK68_02865 ENOG4105KME endoribonuclease L-psp GCK68_02935 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GCK68_02940 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GCK68_02945 ENOG4105VCC 30S ribosomal protein S21 GCK68_02965 ENOG4107ZVW dihydroneopterin aldolase GCK68_02980 ENOG4106MWK domain protein GCK68_02985 ENOG4105I7R Adenylate cyclase GCK68_03000 ENOG4105DVH amino acid GCK68_03010 ENOG4105W0Z cytoplasmic protein GCK68_03020 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GCK68_03025 ENOG4106032 Glutathionylspermidine synthase GCK68_03040 ENOG4105DFG type I secretion outer membrane protein GCK68_03045 ENOG41087AY ADP-Ribose pyrophosphatase GCK68_03050 ENOG4108SX3 cytoplasmic protein GCK68_03055 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GCK68_03060 ENOG4105IPS esterase GCK68_03065 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GCK68_03070 ENOG4105CR8 Transcriptional regulator GCK68_03075 ENOG4105NF4 modulator of drug activity GCK68_03085 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GCK68_03090 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GCK68_03100 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) GCK68_03115 ENOG4105CV8 reductase GCK68_03125 ENOG4108I6A alcohol dehydrogenase GCK68_03130 ENOG4105CF7 AraC family transcriptional regulator GCK68_03135 ENOG4108K81 inner membrane protein YghB GCK68_03140 ENOG4105C28 cystathionine GCK68_03145 ENOG4105CWK Biopolymer transport protein, ExbB GCK68_03150 ENOG4108ZZF transport protein (ExbD) GCK68_03225 ENOG4108RS6 transposase GCK68_03230 ENOG4106PG1 outer membrane usher protein GCK68_03235 ENOG4106P2F Pfam:Pili_assembly_C GCK68_03245 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein GCK68_03270 ENOG4105D00 flagellar biosynthetic protein flhB GCK68_03275 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GCK68_03280 ENOG4105VS8 Flagellar biosynthetic protein fliq GCK68_03285 ENOG4105CN7 Flagellar biosynthetic protein FliP GCK68_03290 ENOG4105DD5 Flagellar motor switch protein GCK68_03300 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GCK68_03310 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GCK68_03325 ENOG4108JIR Flagellum-specific ATP synthase GCK68_03345 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA GCK68_03350 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GCK68_03355 ENOG4108ZC9 flagellar basal-body rod protein flgc GCK68_03360 ENOG4105W00 Flagellar hook capping protein GCK68_03365 ENOG4105BZE flagellar hook protein, FlgE GCK68_03370 ENOG4108KPB Flagellar basal-body rod protein FlgF GCK68_03375 ENOG4105CGA flagellar basal-body rod protein FlgG GCK68_03380 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GCK68_03385 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GCK68_03395 ENOG4105E1Q flagellar hook-associated protein GCK68_03415 ENOG4108M3R transcriptional activator CadC GCK68_03435 ENOG4105ETE Transcriptional regulator (LacI family GCK68_03440 ENOG4105C8P )-transporter GCK68_03445 ENOG41062WK cellular response to acidity GCK68_03460 ENOG4105CNA YD repeat protein GCK68_03470 ENOG4105CS6 Rhs element vgr protein GCK68_03485 ENOG4107EFN gluconate transport system permease 3 GCK68_03500 ENOG4105BZ1 (ABC) transporter GCK68_03540 ENOG4105C0W non-ribosomal peptide synthetase GCK68_03555 ENOG4108RS6 transposase GCK68_03560 ENOG4105CBG Sulfatase GCK68_03565 ENOG4105E98 transcriptional regulator DeoR family GCK68_03570 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GCK68_03575 ENOG4105E70 isomerase GCK68_03580 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB GCK68_03585 ENOG4105ETZ PTS System GCK68_03590 ENOG4105F3R pts system mannose fructose sorbose family iid GCK68_03595 ENOG4108YTN IIa component GCK68_03600 ENOG4105CE4 GlcNAc 6-P deacetylase GCK68_03605 ENOG4105CHR reductase GCK68_03615 ENOG4105C4X radical SAM domain protein GCK68_03620 ENOG4105ENH Sulfatase GCK68_03630 ENOG4105D2N Aldolase GCK68_03645 ENOG4105ETE Transcriptional regulator (LacI family GCK68_03650 ENOG4105DPW Major facilitator superfamily MFS_1 GCK68_03660 ENOG4105ETE Transcriptional regulator (LacI family GCK68_03670 ENOG4105CI1 PTS System GCK68_03675 ENOG4105C4C beta-galactosidase GCK68_03685 ENOG4105EG2 ABC transporter, permease GCK68_03695 ENOG4107FKK extracellular solute-binding protein family 1 GCK68_03710 ENOG4105CNN ABC, transporter GCK68_03715 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GCK68_03725 ENOG4108UY0 (LipO)protein GCK68_03730 ENOG4105NTW Transcriptional regulator GCK68_03820 ENOG4105WJ3 XRE family Transcriptional regulator GCK68_03825 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation GCK68_03845 ENOG4105DFP Integrase GCK68_03865 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GCK68_03870 ENOG4105T95 Thiol disulfide interChange protein GCK68_03875 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GCK68_03880 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GCK68_03885 ENOG4105CT7 inner membrane cred family protein GCK68_03890 ENOG4105EB3 Histidine kinase GCK68_03895 ENOG4105E3W Two component transcriptional regulator (Winged helix family GCK68_03905 ENOG4105Y75 tpr repeat protein GCK68_03920 ENOG4108UT2 hemolysin iii GCK68_03965 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GCK68_03970 ENOG4105D0A hydroxylase GCK68_03975 ENOG4107RAQ aminopeptidase GCK68_03995 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GCK68_04000 ENOG4108JQ1 Dehydrogenase GCK68_04005 ENOG4105E66 phosphoriboisomerase A GCK68_04015 ENOG4105MPN Membrane GCK68_04025 ENOG4105D64 Mechanosensitive ion channel GCK68_04035 ENOG4105D2N Aldolase GCK68_04050 ENOG4108RS6 transposase GCK68_04055 ENOG4105CV1 Transketolase (EC 2.2.1.1) GCK68_04060 ENOG4108K0D peptidase, M48 GCK68_04075 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) GCK68_04090 ENOG4105RWS endonuclease I GCK68_04095 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GCK68_04100 ENOG4105D7Z glutathione synthase GCK68_04115 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) GCK68_04125 ENOG4105CZX twitching motility protein GCK68_04130 ENOG4105DFA alanine racemase domain protein GCK68_04135 ENOG4105II7 pyrroline-5-carboxylate reductase GCK68_04145 ENOG4108VIA integral membrane protein GCK68_04155 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GCK68_04160 ENOG4105CSA Coproporphyrinogen iii oxidase GCK68_04165 ENOG4105EUK rtx toxin RtxA GCK68_04175 ENOG4105CSV Glutaminase GCK68_04180 ENOG41090ED Protein with unknown function (DUF469) GCK68_04190 ENOG4105CEN a g-specific adenine glycosylase GCK68_04215 ENOG4105CNN ABC, transporter GCK68_04220 ENOG4105C2J ABC transporter GCK68_04225 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GCK68_04230 ENOG4105CXN decarboxylase GCK68_04305 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GCK68_04315 ENOG4105CDV Ompa motb domain protein GCK68_04400 ENOG4105DUU IucA IucC family protein GCK68_04405 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GCK68_04415 ENOG4105CT4 transporter GCK68_04425 ENOG4105BZU Histidine kinase GCK68_04435 ENOG4105C1P efflux transporter, rnd family, mfp subunit GCK68_04490 ENOG4105CFC Transporter GCK68_04495 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GCK68_04500 ENOG4107ZSV Receptor GCK68_04545 ENOG4107B2H carbonic anhydrase GCK68_04570 ENOG4107QHF type ii secretion system protein e GCK68_04580 ENOG4105D7Q type ii secretion system GCK68_04640 ENOG4105C8Q Methyl-accepting chemotaxis GCK68_04655 ENOG4105EJC lysr family transcriptional regulator GCK68_04660 ENOG4105F27 Major Facilitator GCK68_04665 ENOG4105RQF LysR family Transcriptional regulator GCK68_04670 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GCK68_04675 ENOG41060NJ transcriptional regulator GCK68_04705 ENOG4105CPC Aldo Keto reductase GCK68_04730 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GCK68_04770 ENOG4105DSY exodeoxyribonuclease V, gamma GCK68_04775 ENOG4107QXK peptidase GCK68_04780 ENOG4107QKA exodeoxyribonuclease V beta GCK68_04785 ENOG4107QYX exodeoxyribonuclease v alpha GCK68_04795 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GCK68_04810 ENOG4105CA3 membrane-bound lytic murein transglycosylase GCK68_04815 ENOG4105CUZ uba thif-type nad fad binding protein GCK68_04820 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GCK68_04825 ENOG4105C9B Cysteine desulfurase GCK68_04835 ENOG4105ETT transcriptional Regulator, LysR family GCK68_04840 ENOG4105M08 Membrane GCK68_04850 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease GCK68_04870 ENOG4105EWT decarboxylase family GCK68_04885 ENOG4108RS6 transposase GCK68_04890 ENOG4105WP7 tRNA pseudouridine synthase C GCK68_04895 ENOG4105DR9 pseudouridine synthase GCK68_04900 ENOG4105QDK Flavodoxin GCK68_04920 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GCK68_04955 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GCK68_04960 ENOG4105KNE Phosphatidate cytidylyltransferase GCK68_04965 ENOG4105DZP Membrane-associated zinc metalloprotease GCK68_04975 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) GCK68_04995 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GCK68_05005 ENOG4105C0B DNA polymerase III (alpha subunit) GCK68_05015 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GCK68_05020 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GCK68_05030 ENOG4105M1T rho-binding antiterminator GCK68_05040 ENOG4108VWS Yaeq family GCK68_05045 ENOG4108YZN class I peptide chain release factor GCK68_05050 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion GCK68_05060 ENOG4108R96 Methyltransferase, YaeB family GCK68_05065 ENOG4108R8X outer membrane lipoprotein GCK68_05070 ENOG4105D01 (LipO)protein GCK68_05075 ENOG4108UMI ABC transporter, permease GCK68_05085 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GCK68_05120 ENOG4105CV8 reductase GCK68_05135 ENOG4105E9H Lytic Murein transglycosylase GCK68_05145 ENOG4105D1A Methyltransferase GCK68_05155 ENOG4108JDX DNA polymerase iii, epsilon subunit GCK68_05165 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GCK68_05190 ENOG4105VUH addiction module killer protein GCK68_05250 ENOG4105DFP Integrase GCK68_05260 ENOG4108RS6 transposase GCK68_05275 ENOG4108Z1B Cyclase dehydrase GCK68_05285 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GCK68_05290 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GCK68_05295 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GCK68_05305 ENOG4105BZN citrate synthase GCK68_05310 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GCK68_05315 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GCK68_05325 ENOG4105E33 succinate dehydrogenase GCK68_05330 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GCK68_05335 ENOG4105C7S Dehydrogenase GCK68_05345 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GCK68_05350 ENOG4105C4M (Ubiquinol oxidase) subunit I GCK68_05355 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GCK68_05365 ENOG4105KJB cyd operon protein YbgE GCK68_05370 ENOG4107YD3 Thioesterase GCK68_05375 ENOG4105E02 MotA TolQ exbB proton channel GCK68_05380 ENOG4105M8F Biopolymer transport protein exbD tolR GCK68_05385 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA GCK68_05385 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA GCK68_05395 ENOG4105KCK Peptidoglycan-associated lipoprotein GCK68_05400 ENOG4105UFD tol-pal system protein YbgF GCK68_05425 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GCK68_05430 ENOG4105PGM cation diffusion facilitator family transporter GCK68_05435 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GCK68_05450 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GCK68_05465 ENOG4105F0Z galactose-1-phosphate uridylyltransferase GCK68_05470 ENOG4105CMR udp-glucose 4-epimerase GCK68_05480 ENOG4105DKW ABC transporter GCK68_05490 ENOG4105F4R Transcriptional regulator mode GCK68_05495 ENOG410680R Protein of unknown function (DUF2592) GCK68_05500 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GCK68_05505 ENOG4105E0C molybdate abc transporter GCK68_05515 ENOG4108K4B hydrolase GCK68_05540 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GCK68_05545 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GCK68_05550 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GCK68_05555 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GCK68_05560 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GCK68_05565 ENOG4105CHW UPF0052 protein GCK68_05570 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GCK68_05580 ENOG4105M00 molybdopterin converting factor, subunit 1 GCK68_05585 ENOG4108ZAF Molybdopterin GCK68_05590 ENOG4105HFZ Membrane GCK68_05595 ENOG4108RS6 transposase GCK68_05605 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GCK68_05615 ENOG41061WM D-Alanyl-D-Alanine GCK68_05620 ENOG4105CXG d-lactate dehydrogenase GCK68_05630 ENOG4105N1F Hnh endonuclease GCK68_05640 ENOG4105Y3U Transglycosylase-associated protein GCK68_05650 ENOG4106ZX3 phosphonate ABC transporter, periplasmic phosphonate-binding protein GCK68_05665 ENOG4108W15 Protein of unknown function (DUF1456) GCK68_05675 ENOG4105C32 Amino acid ABC transporter (Permease) GCK68_05680 ENOG4105CNN ABC, transporter GCK68_05685 ENOG4108JJB ABC transporter GCK68_05690 ENOG4108IV0 ABC, transporter GCK68_05705 ENOG4105KHC sulfurtransferase GCK68_05710 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GCK68_05715 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GCK68_05720 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component GCK68_05725 ENOG4108IJ8 ABC transporter GCK68_05730 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component GCK68_05735 ENOG4105D5Q Arginine ornithine antiporter GCK68_05740 ENOG4105CXN decarboxylase GCK68_05750 ENOG4105FDR Membrane GCK68_05760 ENOG4105DVT helicase GCK68_05765 ENOG4105CH6 catalase GCK68_05770 ENOG4108UII YfaZ family GCK68_05775 ENOG4105E0U tyrosine-specific transport protein GCK68_05790 ENOG4105XPH Ferredoxin GCK68_05795 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GCK68_05800 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GCK68_05810 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GCK68_05815 ENOG4105BZU Histidine kinase GCK68_05820 ENOG41068CG regulatoR GCK68_05825 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC GCK68_05830 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC GCK68_05835 ENOG4106UW1 Major Facilitator superfamily GCK68_05840 ENOG4105FCK Membrane GCK68_05845 ENOG4108RS6 transposase GCK68_05865 ENOG4107R6D beta-lactam binding protein AmpH GCK68_05870 ENOG4105CT4 transporter GCK68_05880 ENOG4105C8Q Methyl-accepting chemotaxis GCK68_05895 ENOG4105Y50 Virulence Protein GCK68_05905 ENOG4105HRS Antitermination protein GCK68_05910 ENOG4105G63 Type III effector Hrp-dependent GCK68_05920 ENOG4105MVE transcriptional regulator GCK68_05925 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GCK68_05945 ENOG4105TKZ Tail Sheath GCK68_05985 ENOG4108T86 baseplate J family protein GCK68_06005 ENOG4108Q3X Transcriptional regulator GCK68_06010 ENOG4105CS2 ec 3.2.1.21 GCK68_06025 ENOG4105GMB type VI secretion system effector, hcp1 family GCK68_06045 ENOG4105E68 Sulfatase GCK68_06050 ENOG4105PAN UPF0352 protein GCK68_06060 ENOG4108RS6 transposase GCK68_06075 ENOG4105CFI type iii restriction protein res subunit GCK68_06080 ENOG4105I08 Pseudouridine synthase GCK68_06085 ENOG4105C2C drug resistance transporter, Bcr CflA GCK68_06090 ENOG4105HG6 GCK68_06095 ENOG4108JQ5 ABC transporter GCK68_06100 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GCK68_06105 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GCK68_06110 ENOG4105E43 Extracellular solute-binding protein, family 5 GCK68_06115 ENOG4105CXC rtn protein GCK68_06120 ENOG4107TT5 NLP P60 protein GCK68_06125 ENOG41076MN Phosphoesterase, PA-phosphatase related GCK68_06130 ENOG4105CKI cobalamin synthesis protein GCK68_06140 ENOG4107YCY Transcriptional regulator GCK68_06145 ENOG4105DEI Mannitol dehydrogenase GCK68_06150 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GCK68_06165 ENOG4105KRS Proteinase inhibitor GCK68_06170 ENOG4105CHR reductase GCK68_06185 ENOG4105C26 Dehydrogenase GCK68_06195 ENOG4105E66 phosphoriboisomerase A GCK68_06205 ENOG4105C2J ABC transporter GCK68_06210 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GCK68_06220 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GCK68_06225 ENOG4105DE4 1-phosphofructokinase GCK68_06230 ENOG4105DM4 PTS System GCK68_06235 ENOG4108SGD regulatory protein GCK68_06250 ENOG4108UIF Chaperone GCK68_06255 ENOG4108D1K outer membrane usher protein GCK68_06265 ENOG4105HMI Membrane GCK68_06270 ENOG4105DUM transcriptional regulator, lysR family GCK68_06275 ENOG4108IQI permease GCK68_06285 ENOG4105EHG Permease protein GCK68_06295 ENOG4105D05 Receptor GCK68_06305 ENOG4108TGY Glutathione S-transferase GCK68_06320 ENOG4105D01 (LipO)protein GCK68_06330 ENOG4108UMI ABC transporter, permease GCK68_06335 ENOG4105DZ1 carboxypeptidase GCK68_06340 ENOG4105C44 Serine transporter GCK68_06345 ENOG4107FB0 transcriptional regulator DeoR family GCK68_06350 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GCK68_06355 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GCK68_06365 ENOG4105D0C transport protein GCK68_06370 ENOG41090BQ Glutaredoxin GCK68_06375 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress GCK68_06385 ENOG4108RMJ sensory transduction regulator GCK68_06390 ENOG4107RUE extracellular solute-binding protein family 1 GCK68_06395 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GCK68_06400 ENOG4105F38 ABC transporter, permease GCK68_06405 ENOG4105D38 putrescine abc transporter GCK68_06410 ENOG4105RBQ inner membrane protein ybjO GCK68_06420 ENOG4106TNF Periplasmic binding protein GCK68_06445 ENOG4105EHG Permease protein GCK68_06450 ENOG4105DQ5 transport system permease protein GCK68_06455 ENOG4105E0A ABC, transporter GCK68_06460 ENOG410642S Nicotianamine synthase protein GCK68_06465 ENOG4108MRU Uncharacterized protein conserved in bacteria (DUF2338) GCK68_06470 ENOG4108I0N Transporter, RarD family, DMT superfamily protein GCK68_06475 ENOG4105DMR ABC, transporter GCK68_06480 ENOG4105GBT ABC transporter GCK68_06485 ENOG4106PMH Extracellular solute-binding protein family 3 GCK68_06490 ENOG4105E5Z arginine transporter ATP-binding subunit GCK68_06495 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) GCK68_06500 ENOG41064MM (LipO)protein GCK68_06505 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GCK68_06510 ENOG4105CGD Nad-dependent epimerase dehydratase GCK68_06515 ENOG4105C5W Aldolase GCK68_06525 ENOG4105C7K acetolactate synthase GCK68_06530 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GCK68_06545 ENOG4105CPB ATP-dependent endonuclease of the OLD family GCK68_06550 ENOG4108MJ5 VirK protein GCK68_06555 ENOG4105DJY efflux transporter, rnd family, mfp subunit GCK68_06565 ENOG4105VEQ Cold shock protein GCK68_06580 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GCK68_06585 ENOG4108RS6 transposase GCK68_06595 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GCK68_06605 ENOG4108JJ8 (ABC) transporter GCK68_06610 ENOG4108JJ9 ABC, transporter GCK68_06615 ENOG4105C3M thioredoxin reductase GCK68_06620 ENOG4105EW9 transcriptional regulator AsnC family GCK68_06625 ENOG4105CNU cell division protein FtsK GCK68_06635 ENOG4105D1H recombination factor protein RarA GCK68_06665 ENOG4105F1A Pyruvate formate-lyase GCK68_06675 ENOG4105C6N Formate acetyltransferase GCK68_06680 ENOG4105TMB Formate nitrite transporter GCK68_06685 ENOG4105DDY UPF0142 protein ycaO GCK68_06690 ENOG4105HDK L-asparaginase GCK68_06695 ENOG4105EUR Domain-Containing protein GCK68_06695 ENOG4105EUR Domain-Containing protein GCK68_06720 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GCK68_06735 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GCK68_06750 ENOG4105E32 cytoplasmic protein GCK68_06760 ENOG4105VEQ Cold shock protein GCK68_06765 ENOG4105W49 UPF0434 protein GCK68_06780 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups GCK68_06795 ENOG4106371 Methyltransferase GCK68_06800 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) GCK68_06805 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GCK68_06815 ENOG4108RS6 transposase GCK68_06820 ENOG4105DIT ErfK YbiS YcfS YnhG family protein GCK68_06825 ENOG4105EAQ (twin-arginine translocation) pathway signal GCK68_06830 ENOG4105C5X domain protein GCK68_06840 ENOG4105CGF Aromatic amino acid aminotransferase GCK68_06860 ENOG4105CD8 aminopeptidase N GCK68_06870 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GCK68_06875 ENOG4105QVC MOSC domain-containing protein GCK68_06885 ENOG4105C5H ABC transporter GCK68_06890 ENOG4105F1S paraquat-inducible protein a GCK68_06895 ENOG4105DY2 Paraquat-inducible protein b GCK68_06900 ENOG4108Q2G (LipO)protein GCK68_06910 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) GCK68_06915 ENOG4108RS6 transposase GCK68_06950 ENOG4105DAN ATP-dependent protease GCK68_06960 ENOG4108RS6 transposase GCK68_06965 ENOG4105UYK outer membrane protein a GCK68_06975 ENOG4108RZ1 DNA transformation protein GCK68_06980 ENOG4105EM2 membrane GCK68_06985 ENOG410901E Membrane GCK68_06990 ENOG41088T4 Helicase IV GCK68_07000 ENOG4108Q67 UPF0319 protein GCK68_07005 ENOG4105K4P CoA-binding domain protein GCK68_07025 ENOG4108Z0T Part of a sulfur-relay system (By similarity) GCK68_07060 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GCK68_07065 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GCK68_07070 ENOG4105CHR reductase GCK68_07075 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase GCK68_07085 ENOG4108KQ6 Enoyl-CoA hydratase GCK68_07090 ENOG4105CHR reductase GCK68_07100 ENOG41062T2 Acyl carrier protein GCK68_07105 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GCK68_07130 ENOG4105CDV Ompa motb domain protein GCK68_07140 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GCK68_07235 ENOG4105C5H ABC transporter GCK68_07250 ENOG4105D06 uba thif-type nad fad binding protein GCK68_07255 ENOG4105CVM Molybdenum cofactor synthesis domain protein GCK68_07265 ENOG4105C19 ABC transporter GCK68_07270 ENOG4105ENT Efflux transporter rnd family, mfp subunit GCK68_07295 ENOG4105EGI Transcriptional regulator GCK68_07300 ENOG4105CBP Major Facilitator GCK68_07310 ENOG4105DHF Membrane GCK68_07325 ENOG4108HWV )-transporter GCK68_07330 ENOG4107GZ4 SanA protein GCK68_07345 ENOG41067MG lrgb family GCK68_07355 ENOG4105E5W Transporter GCK68_07375 ENOG4108RS6 transposase GCK68_07385 ENOG4105D1F ATP-binding protein GCK68_07400 ENOG4108GAE asmA family GCK68_07405 ENOG4105EE5 Membrane protein terC GCK68_07410 ENOG4108819 ferric iron reductase GCK68_07415 ENOG4105DY8 decarboxylase GCK68_07420 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GCK68_07430 ENOG4105DUU IucA IucC family protein GCK68_07435 ENOG4105E0A ABC, transporter GCK68_07440 ENOG4105TVJ transport system, permease GCK68_07445 ENOG4105DQ5 transport system permease protein GCK68_07450 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GCK68_07455 ENOG4105CNM Receptor GCK68_07465 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GCK68_07470 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GCK68_07475 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GCK68_07480 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GCK68_07495 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GCK68_07500 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GCK68_07510 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GCK68_07525 ENOG4108535 NAD dependent epimerase/dehydratase family GCK68_07530 ENOG4105CNN ABC, transporter GCK68_07535 ENOG4105C2J ABC transporter GCK68_07540 ENOG4105C2J ABC transporter GCK68_07545 ENOG4107SCQ Iron-containing alcohol dehydrogenase GCK68_07555 ENOG4105CUB amino acid GCK68_07565 ENOG4105CJB Exodeoxyribonuclease I GCK68_07585 ENOG4105TNG K13735 adhesin invasin GCK68_07590 ENOG4105CSP Major Facilitator Superfamily GCK68_07595 ENOG4105KIR Thiol-disulfide oxidoreductase dcc GCK68_07600 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GCK68_07610 ENOG4105DIA mandelate racemase muconate lactonizing GCK68_07630 ENOG4105UQX Mate efflux family protein GCK68_07650 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme GCK68_07660 ENOG4108KX4 response regulator GCK68_07665 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GCK68_07675 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GCK68_07680 ENOG4108TSE Transferase GCK68_07695 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GCK68_07755 ENOG4105BZ1 (ABC) transporter GCK68_07775 ENOG4105N4N Protein of unknown function (DUF2766) GCK68_07790 ENOG41064PC GCK68_07810 ENOG4105C85 amino acid GCK68_07825 ENOG410610J Protein of unknown function (DUF2627) GCK68_07830 ENOG4105VEQ Cold shock protein GCK68_07835 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GCK68_07840 ENOG4105DHI Methyltransferase GCK68_07870 ENOG4105F3R pts system mannose fructose sorbose family iid GCK68_07875 ENOG4105ETZ PTS System GCK68_07880 ENOG4108EQA pts system GCK68_07895 ENOG4108V8F Transcriptional regulator, MarR family GCK68_07910 ENOG4105C26 Dehydrogenase GCK68_07915 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase GCK68_07940 ENOG4105EFA 4-hydroxyphenylacetate GCK68_07945 ENOG4107UWN reductase GCK68_07950 ENOG4105EJQ L-serine dehydratase GCK68_07960 ENOG4105CRQ synthase (Component I) GCK68_07975 ENOG4105C1J atp-dependent rna helicase GCK68_07980 ENOG4105X2V dna damage-inducible protein GCK68_07995 ENOG4105CUG Oligopeptidase b GCK68_08005 ENOG4105MPK DNA polymerase III subunit theta GCK68_08010 ENOG41090A1 ferritin GCK68_08015 ENOG4105FXM Copper resistance protein GCK68_08025 ENOG4105NKT exported protein GCK68_08045 ENOG4105D00 flagellar biosynthetic protein flhB GCK68_08050 ENOG4105D7B Flagellar biosynthesis protein flha GCK68_08055 ENOG4105W13 flagellar protein GCK68_08065 ENOG4108RS6 transposase GCK68_08075 ENOG4105QVD Flagella synthesis protein FlgN GCK68_08080 ENOG4105M9M anti-sigma28 factor FlgM GCK68_08085 ENOG4105CKS Flagella basal body P-ring formation protein flgA GCK68_08090 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GCK68_08095 ENOG4108ZC9 flagellar basal-body rod protein flgc GCK68_08100 ENOG4105W00 Flagellar hook capping protein GCK68_08105 ENOG4105BZE flagellar hook protein, FlgE GCK68_08115 ENOG4105CGA flagellar basal-body rod protein FlgG GCK68_08130 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GCK68_08135 ENOG4105E1Q flagellar hook-associated protein GCK68_08140 ENOG4105DTJ flagellar hook-associated protein GCK68_08145 ENOG4105DKT Transcriptional regulator GCK68_08155 ENOG4105CNN ABC, transporter GCK68_08165 ENOG4105C2J ABC transporter GCK68_08170 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GCK68_08175 ENOG4108MGF sugar kinase GCK68_08190 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GCK68_08195 ENOG4105VS8 Flagellar biosynthetic protein fliq GCK68_08200 ENOG4105CN7 Flagellar biosynthetic protein FliP GCK68_08210 ENOG4105DD5 Flagellar motor switch protein GCK68_08215 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GCK68_08220 ENOG4107ZI8 flagellar basal body-associated protein flil GCK68_08225 ENOG4105WF4 Flagellar hook-length control protein GCK68_08230 ENOG4105GSA Flagellar export protein flij GCK68_08235 ENOG4108JIR Flagellum-specific ATP synthase GCK68_08240 ENOG41090PJ Flagellar assembly protein GCK68_08245 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GCK68_08250 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GCK68_08255 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GCK68_08280 ENOG4105DHT Metal Dependent Phosphohydrolase GCK68_08285 ENOG4108T5G Adenylate GCK68_08305 ENOG4105MQ3 flagellar protein FliS GCK68_08310 ENOG4105DTS flagellar hook-associated GCK68_08315 ENOG4105I03 Flagellin GCK68_08320 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GCK68_08325 ENOG4108M9K flagella biosynthesis protein FliZ GCK68_08330 ENOG4105K6H D-cysteine desulfhydrase GCK68_08335 ENOG4105EAB amino acid AbC transporter GCK68_08340 ENOG4105E5Q amino acid AbC transporter GCK68_08345 ENOG4105CDA abc transporter atp-binding protein GCK68_08360 ENOG4105C26 Dehydrogenase GCK68_08370 ENOG4105CK7 Sodium proline symporter GCK68_08385 ENOG4105DBE peroxidase GCK68_08400 ENOG4105C85 amino acid GCK68_08410 ENOG4108T1M outer membrane protein x GCK68_08425 ENOG4105RA2 Membrane GCK68_08430 ENOG4105XVG cytoplasmic protein GCK68_08435 ENOG4105WH1 Two component transcriptional regulator luxr family GCK68_08500 ENOG4108WC9 type VI secretion system effector, hcp1 family GCK68_08580 ENOG4105FDP GntR family transcriptional regulator GCK68_08590 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GCK68_08605 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GCK68_08610 ENOG4108IJ9 (ABC) transporter GCK68_08660 ENOG4105CZE histidine utilization repressor GCK68_08665 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GCK68_08670 ENOG41090B9 response to stress GCK68_08685 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GCK68_08755 ENOG4108WF3 methyltransferase GCK68_08795 ENOG4105GR3 Histidine kinase GCK68_08805 ENOG4105ENX hydrolase GCK68_08850 ENOG4105C3G gtp-binding protein GCK68_08860 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria GCK68_08865 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GCK68_08890 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GCK68_08895 ENOG4108YY7 Invasion gene expression up-regulator SirB GCK68_08900 ENOG41063JG Transcriptional regulator GCK68_08910 ENOG4105CHH sulfate transporter GCK68_08935 ENOG4105EG2 ABC transporter, permease GCK68_08940 ENOG4105F38 ABC transporter, permease GCK68_08950 ENOG4108RS6 transposase GCK68_08960 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GCK68_08965 ENOG4105E2R ROK family GCK68_08980 ENOG4107XHZ cytoplasmic chaperone TorD family protein GCK68_08985 ENOG4105F3T (LipO)protein GCK68_08995 ENOG4105D9U N-acetyltransferase GCK68_09005 ENOG4105CJR Integral membrane protein (MviN GCK68_09025 ENOG4106ZCM YecM protein GCK68_09045 ENOG4105WJG Glutathione GCK68_09050 ENOG41081XQ Conserved Protein GCK68_09060 ENOG4108TIT dATP pyrophosphohydrolase GCK68_09090 ENOG4105FAV ABC, transporter GCK68_09100 ENOG4105NXV High-affinity zinc uptake system protein GCK68_09105 ENOG4105DR5 peptidase GCK68_09110 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase GCK68_09120 ENOG4105CA9 Pyruvate kinase GCK68_09125 ENOG4106KNT transcriptional regulator GCK68_09130 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GCK68_09140 ENOG4108UHU Aldolase GCK68_09155 ENOG4105M4H endoribonuclease L-psp GCK68_09160 ENOG4105DVT helicase GCK68_09165 ENOG41072GX Peptidase M22 Glycoprotease GCK68_09180 ENOG4105CEY Amp-dependent synthetase and ligase GCK68_09185 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GCK68_09190 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) GCK68_09195 ENOG4107QMS site-determining protein GCK68_09210 ENOG4105CVE Lytic murein transglycosylase GCK68_09215 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GCK68_09225 ENOG4107R08 Integrase GCK68_09250 ENOG4105NY2 NinB protein GCK68_09260 ENOG4105HRS Antitermination protein GCK68_09475 ENOG4105UZW Tail fiber assembly protein GCK68_09495 ENOG4105C3J Cysteine desulfurase GCK68_09530 ENOG4105ED1 spovr family GCK68_09540 ENOG4105CNH Multidrug resistance protein MdtL GCK68_09545 ENOG4105EUB pirin domain protein GCK68_09550 ENOG4105HEI LysR family (Transcriptional regulator GCK68_09565 ENOG4105CYN Serine protein kinase GCK68_09575 ENOG4105GNX MltA-interacting MipA family protein GCK68_09580 ENOG4105DSB aldose 1-epimerase GCK68_09595 ENOG4105VUT cytoplasmic protein GCK68_09600 ENOG4108RWI nicotinamidase GCK68_09605 ENOG4105HDK L-asparaginase GCK68_09610 ENOG4105D07 Signal peptide peptidase, SppA GCK68_09615 ENOG41069NU Nitroreductase GCK68_09620 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GCK68_09625 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GCK68_09630 ENOG4105MTM Protein of unknown function (DUF1496) GCK68_09635 ENOG4105M6F mutator MutT protein GCK68_09640 ENOG4105CGK Exodeoxyribonuclease III GCK68_09645 ENOG4105SKE transcriptional Regulator LysR family GCK68_09670 ENOG4105CIY formyltetrahydrofolate deformylase GCK68_09680 ENOG4105I93 response regulator GCK68_09685 ENOG4105C6Y Udp-glucose 6-dehydrogenase GCK68_09695 ENOG4107104 thymidine kinase GCK68_09710 ENOG4108RS6 transposase GCK68_09715 ENOG4105CTD carboxy-peptidase GCK68_09720 ENOG4105JJR Histidine kinase GCK68_09725 ENOG4107EXC regulatoR GCK68_09735 ENOG4105D5Q Arginine ornithine antiporter GCK68_09740 ENOG4105C5D exported protein GCK68_09750 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GCK68_09755 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GCK68_09760 ENOG4105Q9Y Universal stress protein GCK68_09765 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GCK68_09770 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GCK68_09785 ENOG4105PAD Hydrolase GCK68_09790 ENOG4105M71 acetolactate synthase 1 regulatory subunit GCK68_09795 ENOG4105C7K acetolactate synthase GCK68_09825 ENOG4105FYV Amp nucleosidase GCK68_09835 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GCK68_09840 ENOG4107UWC ABC, transporter GCK68_09855 ENOG41060NJ transcriptional regulator GCK68_09865 ENOG4105CMQ Chloride channel GCK68_09870 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GCK68_09875 ENOG4105DAG ROK family GCK68_09880 ENOG4106NZI LysR family Transcriptional regulator GCK68_09885 ENOG4105D94 Major Facilitator Superfamily GCK68_09890 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) GCK68_09895 ENOG4105C9Q fumarate hydratase class II GCK68_09900 ENOG4105EIP mannose-6-phosphate isomerase GCK68_09905 ENOG4106J39 exported protein GCK68_09915 ENOG4105DHU Bile acid GCK68_09920 ENOG4105D9R oxidoreductase GCK68_09930 ENOG4105CNN ABC, transporter GCK68_09940 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator GCK68_09955 ENOG4108JJA ABC, transporter GCK68_09960 ENOG4105C42 Type I secretion membrane fusion protein (HlyD GCK68_09975 ENOG4105M9B inner membrane protein ydgK GCK68_09995 ENOG4105UEI Transcriptional Regulator AraC Family GCK68_10000 ENOG4105D6A Electron transport complex GCK68_10005 ENOG4108UQQ Electron transport complex GCK68_10015 ENOG4105CSM endonuclease III GCK68_10020 ENOG4105EXW epimerase dehydratase GCK68_10025 ENOG4105CSP Major Facilitator Superfamily GCK68_10035 ENOG4105D22 carbon starvation protein GCK68_10040 ENOG4105VCD cytoplasmic protein GCK68_10045 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GCK68_10055 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GCK68_10060 ENOG41061RM osmotically inducible lipoprotein GCK68_10065 ENOG4108ZJT translation initiation factor, Sui1 GCK68_10080 ENOG4105CFV Tetratricopeptide repeat protein GCK68_10085 ENOG4105Q4A inner membrane protein yciS GCK68_10090 ENOG4105EYK Phosphatidylglycerophosphatase B GCK68_10095 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GCK68_10100 ENOG4107QM5 aconitate hydratase GCK68_10110 ENOG4107R11 Transcriptional regulator GCK68_10115 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GCK68_10125 ENOG4105RKX Protein of unknown function (DUF2498) GCK68_10130 ENOG4105ERU peptidase GCK68_10135 ENOG4105UBK short-chain dehydrogenase reductase GCK68_10140 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GCK68_10145 ENOG4105FE9 pseudouridine synthase GCK68_10150 ENOG4107RTD sua5 ycio yrdc ywlc family protein GCK68_10155 ENOG4105DB7 PHP domain protein GCK68_10175 ENOG4105DDQ anthranilate synthase GCK68_10185 ENOG4105DK0 Indole-3-glycerol phosphate synthase GCK68_10205 ENOG4105EIF outer membrane protein W GCK68_10240 ENOG4105NAU thioesterase Superfamily protein GCK68_10250 ENOG410822N TonB family GCK68_10255 ENOG4105K9H YciI-like protein GCK68_10270 ENOG4108T1M outer membrane protein x GCK68_10295 ENOG4108JQ7 (ABC) transporter GCK68_10300 ENOG4105C3U ABC transporter GCK68_10305 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GCK68_10315 ENOG4107QSI ABC, transporter GCK68_10320 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GCK68_10330 ENOG4108EKI Dehydrogenase GCK68_10380 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap GCK68_10395 ENOG4105CQ7 ATP-dependent helicase GCK68_10405 ENOG4105DKT Transcriptional regulator GCK68_10410 ENOG4105DEI Mannitol dehydrogenase GCK68_10415 ENOG4105WXT Conserved Protein GCK68_10420 ENOG410689M (LipO)protein GCK68_10425 ENOG4107H52 Dicarboxylate transport GCK68_10430 ENOG4105C5I Dehydrogenase GCK68_10435 ENOG41090X5 Heat shock protein hslJ GCK68_10445 ENOG4105KT7 mgtC SapB transporter GCK68_10455 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) GCK68_10485 ENOG4107QSI ABC, transporter GCK68_10490 ENOG4105KXI murein peptide amidase A GCK68_10495 ENOG4107S8C mandelate racemase muconate lactonizing GCK68_10500 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GCK68_10505 ENOG4108RS6 transposase GCK68_10530 ENOG4105CM6 amino acid regulated cytosolic protein GCK68_10540 ENOG4105FM1 phage shock protein C GCK68_10545 ENOG4105YYT phage shock protein B GCK68_10550 ENOG41087YS Phage shock protein A GCK68_10555 ENOG4105E51 psp operon transcriptional activator GCK68_10560 ENOG4108RS6 transposase GCK68_10570 ENOG4108HIY periplasmic GCK68_10575 ENOG4108I5W peptide transport system, permease protein GCK68_10580 ENOG4108EU3 peptide transport system, permease GCK68_10585 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GCK68_10590 ENOG4108JQ2 peptide transport system atp-binding protein GCK68_10595 ENOG4105Q4T oxidoreductase GCK68_10600 ENOG4105DUX Transporter GCK68_10605 ENOG41069YE inner membrane protein yohC GCK68_10610 ENOG4108ZR5 Conserved Protein GCK68_10615 ENOG4108K3A Glutathione S-transferase GCK68_10635 ENOG410642K Lysozyme inhibitor GCK68_10645 ENOG4108XTF Outer Membrane Lipoprotein GCK68_10660 ENOG4105DIJ Phosphoethanolamine transferase GCK68_10665 ENOG4108WUH Transcriptional regulator, TetR family GCK68_10675 ENOG4108UYE Lactoylglutathione lyase GCK68_10680 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) GCK68_10690 ENOG4105M2J Glutaredoxin GCK68_10700 ENOG4105K4H Nlp p60 protein GCK68_10705 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GCK68_10720 ENOG4105F52 Transcriptional regulator GCK68_10725 ENOG4105CZQ inner membrane transport protein YdhC GCK68_10730 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GCK68_10735 ENOG4108R6K riboflavin synthase, subunit alpha GCK68_10760 ENOG4105CA9 Pyruvate kinase GCK68_10765 ENOG4105KMX major outer membrane lipoprotein GCK68_10770 ENOG4108RS6 transposase GCK68_10785 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GCK68_10800 ENOG4105JRK feS assembly protein SufD GCK68_10805 ENOG4105C3K feS assembly ATPase SufC GCK68_10810 ENOG4105DIW FeS assembly protein SUFB GCK68_10815 ENOG4108Z4V iron-sulfur cluster assembly GCK68_10825 ENOG4105KA0 thioesterase Superfamily protein GCK68_10830 ENOG4105CQB FAD linked oxidase domain protein GCK68_10835 ENOG4105IPI Membrane GCK68_10845 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GCK68_10855 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GCK68_10870 ENOG4108QBX (LipO)protein GCK68_10915 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) GCK68_10920 ENOG4108V06 Glutathione peroxidase GCK68_10935 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GCK68_10940 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GCK68_10945 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GCK68_10975 ENOG41087WU GCK68_11000 ENOG4105DSE periplasmic solute binding protein GCK68_11005 ENOG4105DIK (ABC) transporter GCK68_11010 ENOG4105CC5 ABC transporter GCK68_11015 ENOG4105CC5 ABC transporter GCK68_11025 ENOG4105FGM Fructosamine kinase GCK68_11030 ENOG4107PN8 YfeABCD locus regulator GCK68_11035 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 GCK68_11045 ENOG4105M5J Cupin 2, conserved barrel domain protein GCK68_11055 ENOG4105CHR reductase GCK68_11060 ENOG41061NF Pectate lyase GCK68_11065 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GCK68_11070 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GCK68_11080 ENOG4105WEM extracellular solute-binding protein GCK68_11085 ENOG4108PU9 oligogalacturonate-specific porin GCK68_11090 ENOG4107K5X Membrane-bound metal-dependent hydrolase GCK68_11095 ENOG4108ETY sodium dicarboxylate symporter GCK68_11100 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GCK68_11110 ENOG4105CAZ oligogalacturonide lyase GCK68_11115 ENOG4105C0R drug resistance transporter emrb qaca subfamily GCK68_11120 ENOG4108VEV chaperone GCK68_11135 ENOG4108VEV chaperone GCK68_11140 ENOG4105H8W Fimbrial protein GCK68_11155 ENOG4105CN1 protease GCK68_11165 ENOG4108ZGC gaf domain protein GCK68_11170 ENOG4105H2K paraquat-inducible protein a GCK68_11175 ENOG4105DY2 Paraquat-inducible protein b GCK68_11195 ENOG4105GQR Chaperone GCK68_11210 ENOG4105WT8 Protein of unknown function (DUF1480) GCK68_11250 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GCK68_11260 ENOG4105EUR Domain-Containing protein GCK68_11265 ENOG4105EUR Domain-Containing protein GCK68_11270 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GCK68_11280 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) GCK68_11285 ENOG4108VYJ response regulator receiver protein GCK68_11295 ENOG4105BZU Histidine kinase GCK68_11300 ENOG4105C8Q Methyl-accepting chemotaxis GCK68_11305 ENOG4105C8Q Methyl-accepting chemotaxis GCK68_11325 ENOG4105WWK YheO domain protein GCK68_11335 ENOG4105KME endoribonuclease L-psp GCK68_11340 ENOG4105R9B Major Facilitator GCK68_11345 ENOG4108V3W Chemotaxis protein, CheW GCK68_11350 ENOG4105CBS Chea signal transduction histidine kinase GCK68_11355 ENOG4105ER2 Ompa motb domain protein GCK68_11360 ENOG4107RD7 Flagellar Motor Protein, MotA GCK68_11365 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region GCK68_11375 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GCK68_11380 ENOG4105KT7 mgtC SapB transporter GCK68_11395 ENOG4105VEQ Cold shock protein GCK68_11410 ENOG4105GSJ Inner membrane protein ylaC GCK68_11415 ENOG4108XM1 transcriptional regulator AsnC family GCK68_11425 ENOG41061EV selenium-binding protein YdfZ GCK68_11430 ENOG4105D6F Phosphatase GCK68_11435 ENOG4105KVH Transcriptional regulator GCK68_11440 ENOG4105ECR NmrA family GCK68_11445 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GCK68_11455 ENOG4106NDP Transcriptional regulator GCK68_11460 ENOG4108HMX isocitrate dehydrogenase (NADP) GCK68_11465 ENOG4108R99 pseudouridine synthase GCK68_11485 ENOG4107QTF adenylosuccinate lyase GCK68_11495 ENOG4105XJC Two component transcriptional regulator (Winged helix family GCK68_11505 ENOG4105EZE Cupin 4 family protein GCK68_11520 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GCK68_11535 ENOG4105D60 lipoprotein releasing system transmembrane protein GCK68_11545 ENOG4105D60 lipoprotein releasing system transmembrane protein GCK68_11550 ENOG4108JA2 transcriptioN-repair coupling factor GCK68_11555 ENOG4107MBR 17 kDa surface antigen GCK68_11585 ENOG4105CEP NADH dehydrogenase GCK68_11595 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GCK68_11610 ENOG41090DQ Lipoprotein GCK68_11615 ENOG4105K59 histidine triad (HIT) protein GCK68_11620 ENOG4105F9E Shikimate 5-dehydrogenase GCK68_11640 ENOG4108RS6 transposase GCK68_11645 ENOG4105CI1 PTS System GCK68_11650 ENOG4105F8V Hydrolase, tatD family GCK68_11655 ENOG4107QRG dna polymerase iii GCK68_11665 ENOG4105HHA aminodeoxychorismate lyase GCK68_11670 ENOG4105YAZ 4-amino-4-deoxychorismate lyase GCK68_11675 ENOG4108RS6 transposase GCK68_11680 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GCK68_11690 ENOG4105CHR reductase GCK68_11695 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GCK68_11710 ENOG4105VGS 50s ribosomal protein l32 GCK68_11715 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GCK68_11725 ENOG4105EI2 Pseudouridine synthase GCK68_11730 ENOG4107QQB Ribonuclease E GCK68_11740 ENOG4105PVA Biofilm formation regulatory protein BssS GCK68_11760 ENOG41067V3 Antibiotic biosynthesis monooxygenase GCK68_11790 ENOG4105DSF transport protein GCK68_11810 ENOG4107YC3 synthase GCK68_11815 ENOG4105VJY transcriptional regulator GCK68_11820 ENOG4105ETT transcriptional Regulator, LysR family GCK68_11830 ENOG4105C54 Major Facilitator superfamily GCK68_11840 ENOG4105CPC Aldo Keto reductase GCK68_11845 ENOG4108Y1S CRISPR-associated protein, Csy4 family GCK68_11850 ENOG4105M6W Crispr-associated protein, Csy3 family GCK68_11855 ENOG4105DZX CRISPR-associated protein, Csy2 family GCK68_11860 ENOG4105ENG CRISPR-associated protein, Csy1 family GCK68_11865 ENOG4107IIZ CRISPR-associated helicase, Cas3 GCK68_11870 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GCK68_11875 ENOG4105CUY Mechanosensitive ion channel GCK68_11895 ENOG4105HY2 Glycosidase related protein GCK68_11900 ENOG4105DRS transport system, permease GCK68_11915 ENOG4105ETE Transcriptional regulator (LacI family GCK68_11925 ENOG4108IJ9 (ABC) transporter GCK68_11935 ENOG4105CKT filamentous hemagglutinin GCK68_11940 ENOG4105CKT filamentous hemagglutinin GCK68_11960 ENOG4105CKT filamentous hemagglutinin GCK68_11980 ENOG4105CKT filamentous hemagglutinin GCK68_11985 ENOG4105D5K Hemolysin activator protein GCK68_11990 ENOG4105E3J oxidoreductase GCK68_12000 ENOG4105C94 Transporter GCK68_12010 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GCK68_12015 ENOG4105EJC lysr family transcriptional regulator GCK68_12020 ENOG4105FKQ transcriptional regulator GCK68_12025 ENOG4105CNN ABC, transporter GCK68_12030 ENOG4105C2J ABC transporter GCK68_12035 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GCK68_12040 ENOG4105CPQ Dehydrogenase GCK68_12060 ENOG4108T1M outer membrane protein x GCK68_12090 ENOG4107R0W ABC transporter GCK68_12095 ENOG4105E5Q amino acid AbC transporter GCK68_12100 ENOG4105CDA abc transporter atp-binding protein GCK68_12105 ENOG4107SDU Methyl-accepting chemotaxis GCK68_12135 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction GCK68_12145 ENOG4108MTB glycosyl transferase family GCK68_12150 ENOG4105CEY Amp-dependent synthetase and ligase GCK68_12160 ENOG4108IPT Naphthoate synthase GCK68_12175 ENOG4105E4F Isochorismate synthase GCK68_12185 ENOG4105TNS Conserved Protein GCK68_12200 ENOG4105C01 Dihydroxy-acid dehydratase GCK68_12215 ENOG4105C5I Dehydrogenase GCK68_12220 ENOG4105K2J Transcriptional regulator GCK68_12225 ENOG4105F32 YngK protein GCK68_12240 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GCK68_12245 ENOG4105CHR reductase GCK68_12265 ENOG4105C8S subunit m GCK68_12270 ENOG4105D65 subunit l GCK68_12280 ENOG4107UFS subunit j GCK68_12295 ENOG4108IEH NADH dehydrogenase subunit g GCK68_12300 ENOG4107QIZ NADH dehydrogenase GCK68_12305 ENOG4105GKE subunit e GCK68_12315 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GCK68_12325 ENOG4107NQ8 LysR family Transcriptional regulator GCK68_12330 ENOG4105CHM Aminotransferase GCK68_12345 ENOG4107QWE )-transporter GCK68_12350 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GCK68_12370 ENOG4105C6K Malic enzyme GCK68_12375 ENOG4107P2S Transcriptional regulator GCK68_12400 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GCK68_12405 ENOG4105PTV Nudix Hydrolase GCK68_12420 ENOG4105ECP epimerase GCK68_12425 ENOG4108JEH abc transporter atp-binding protein GCK68_12430 ENOG4106YG3 ABC transporter GCK68_12435 ENOG4105DSP amino acid AbC transporter GCK68_12440 ENOG4105E89 ABC transporter GCK68_12445 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GCK68_12450 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GCK68_12455 ENOG4105E96 Colicin v production protein GCK68_12460 ENOG4108S3P Sporulation domain protein GCK68_12465 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GCK68_12475 ENOG4105DQR SNARE associated Golgi GCK68_12485 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GCK68_12500 ENOG410631K Membrane GCK68_12505 ENOG4106WZ1 flagella biosynthesis regulator GCK68_12520 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GCK68_12530 ENOG4105MH2 YfcL protein GCK68_12535 ENOG4108BPE -transporting atpase GCK68_12540 ENOG4105EJ9 Membrane GCK68_12555 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GCK68_12565 ENOG4108BY2 phosphohistidine phosphatase GCK68_12580 ENOG4105KZW UPF0381 protein GCK68_12585 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GCK68_12590 ENOG410903C (LipO)protein GCK68_12595 ENOG4105KWW Biogenesis protein GCK68_12600 ENOG4105KWW Biogenesis protein GCK68_12605 ENOG4107QX9 Thiol disulfide interChange protein GCK68_12610 ENOG4105DA4 cytochrome c-type biogenesis protein GCK68_12620 ENOG4105X3C heme exporter protein GCK68_12625 ENOG41060IM Heme exporter protein GCK68_12630 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GCK68_12650 ENOG4108V0P LemA family GCK68_12660 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GCK68_12690 ENOG4105CS6 Rhs element vgr protein GCK68_12750 ENOG4105CW0 outer membrane usher protein GCK68_12765 ENOG4105CW0 outer membrane usher protein GCK68_12770 ENOG4105GQR Chaperone GCK68_12780 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GCK68_12830 ENOG4105CVE Lytic murein transglycosylase GCK68_12855 ENOG4108WC9 type VI secretion system effector, hcp1 family GCK68_12865 ENOG4107QY8 reductase GCK68_12870 ENOG4105QAX Iron-sulfur GCK68_12875 ENOG4107KGK dmso reductase anchor subunit GCK68_12880 ENOG4108NEM leader-binding protein dmsD GCK68_12890 ENOG4107Y60 (LipO)protein GCK68_12900 ENOG4106B0W Curli production assembly transport component CsgG GCK68_12910 ENOG4108VKM cytochrome b561 GCK68_12920 ENOG4105CHM Aminotransferase GCK68_12925 ENOG41072TH Protein of unknown function (DUF1479) GCK68_12940 ENOG4105C5Q Transcriptional regulator GCK68_12945 ENOG4105CPC Aldo Keto reductase GCK68_12960 ENOG4105D9N nucleoside GCK68_13000 ENOG4108RS6 transposase GCK68_13030 ENOG4105VRT cytoplasmic protein GCK68_13045 ENOG4105EXN Sulfate transport protein CysZ GCK68_13050 ENOG4105C6T cysteine synthase GCK68_13055 ENOG4105KZ7 phosphocarrier protein hpr GCK68_13065 ENOG4105C5Y PTS System GCK68_13070 ENOG4108RS6 transposase GCK68_13075 ENOG4105E0F Histidine kinase GCK68_13080 ENOG4105E3W Two component transcriptional regulator (Winged helix family GCK68_13085 ENOG4105DJY efflux transporter, rnd family, mfp subunit GCK68_13100 ENOG4105E1V na solute symporter GCK68_13110 ENOG4107RAQ aminopeptidase GCK68_13120 ENOG4105C87 Aminotransferase class I and II GCK68_13130 ENOG41062D9 Histidine kinase GCK68_13135 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GCK68_13145 ENOG4105C6T cysteine synthase GCK68_13150 ENOG4108IJ6 ABC transporter GCK68_13155 ENOG4105ECW sulfate abc transporter GCK68_13160 ENOG4108I5D sulfate abc transporter GCK68_13165 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein GCK68_13175 ENOG4105QEK Transcriptional regulator GCK68_13185 ENOG4108R66 Conserved Protein GCK68_13210 ENOG4105EZR dyp-type peroxidase family protein GCK68_13215 ENOG4105E7K (LipO)protein GCK68_13220 ENOG4105H4F exported protein GCK68_13255 ENOG4105C6K Malic enzyme GCK68_13265 ENOG4105CUW cytochrome C-TYPE protein GCK68_13270 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) GCK68_13280 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase GCK68_13285 ENOG4108ZNS ferredoxin-type protein NapF GCK68_13290 ENOG4105WH1 Two component transcriptional regulator luxr family GCK68_13300 ENOG4105BZS acriflavin resistance protein GCK68_13310 ENOG4105S2T inner membrane protein YbcI GCK68_13315 ENOG4105C4X radical SAM domain protein GCK68_13320 ENOG4105ENH Sulfatase GCK68_13335 ENOG4107Z33 ABC transporter, permease GCK68_13340 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC GCK68_13350 ENOG4105KUZ arsenate reductase GCK68_13385 ENOG4105CGZ zinc metallopeptidase GCK68_13400 ENOG4108RS6 transposase GCK68_13405 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GCK68_13415 ENOG4105RH4 Glycine cleavage system transcriptional repressor GCK68_13420 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GCK68_13435 ENOG4105C02 permease GCK68_13440 ENOG4105ERG peptidase m48, ste24p GCK68_13445 ENOG4105K89 arsenate reductase GCK68_13455 ENOG4108RS6 transposase GCK68_13470 ENOG4108V3E phosphoribosylglycinamide formyltransferase GCK68_13475 ENOG4108MK9 spermidine N(1)-acetyltransferase GCK68_13490 ENOG4105E2Z phosphate ABC transporter (Permease GCK68_13495 ENOG4105C8U phosphate abc transporter GCK68_13500 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GCK68_13505 ENOG4105C9X ppx gppa phosphatase GCK68_13515 ENOG4105CJW magnesium transporter GCK68_13520 ENOG4105R8A Heat shock protein GCK68_13525 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component GCK68_13530 ENOG4105F38 ABC transporter, permease GCK68_13540 ENOG4108JPW Aminotransferase GCK68_13550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GCK68_13580 ENOG4105E3W Two component transcriptional regulator (Winged helix family GCK68_13585 ENOG4105KWI UPF0339 protein GCK68_13590 ENOG4105CFP Peptidase U32 GCK68_13605 ENOG4108ZGU inhibitor of vertebrate lysozyme GCK68_13615 ENOG4105DWF phosphomethylpyrimidine kinase GCK68_13660 ENOG4108WC9 type VI secretion system effector, hcp1 family GCK68_13670 ENOG4108RS6 transposase GCK68_13680 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GCK68_13690 ENOG4105VPD cellular component movement GCK68_13705 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GCK68_13710 ENOG4105N21 Membrane GCK68_13755 ENOG4108MGN ATP-binding component of a transport system GCK68_13760 ENOG4108MGN ATP-binding component of a transport system GCK68_13775 ENOG4105YYA enhanced serine sensitivity protein SseB GCK68_13785 ENOG4105WVQ Fe-S assembly protein IscX GCK68_13790 ENOG4108ZIT Ferredoxin, 2FE-2S GCK68_13815 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GCK68_13820 ENOG4105C3J Cysteine desulfurase GCK68_13840 ENOG4105D7X high-affinity nickel-transporter GCK68_13845 ENOG41065CD Exported protein GCK68_13850 ENOG4108MN2 Stationary phase inducible protein CsiE GCK68_13855 ENOG4105D8G Major Facilitator superfamily GCK68_13875 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GCK68_13905 ENOG4108YZA Nitrogen regulatory protein pii GCK68_13910 ENOG4105C4K Nad synthetase GCK68_13915 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GCK68_13920 ENOG4108SKK alpha helix protein GCK68_13925 ENOG4107WP9 Histidine kinase GCK68_13935 ENOG4108RS6 transposase GCK68_13970 ENOG4108Z6B deaminase GCK68_13975 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB GCK68_13985 ENOG4106G6Q Transcriptional regulator GCK68_13990 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GCK68_13995 ENOG4108RS6 transposase GCK68_14005 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GCK68_14025 ENOG4105C3F Signal peptidase i GCK68_14040 ENOG4105WMJ Positive regulator of sigma E, RseC MucC GCK68_14045 ENOG4105VQK sigma E regulatory protein, MucB RseB GCK68_14050 ENOG41069PW sigma-e factor negative regulatory protein GCK68_14060 ENOG4108IYU L-aspartate oxidase GCK68_14070 ENOG4105C1J atp-dependent rna helicase GCK68_14115 ENOG4107R7A Allophanate hydrolase subunit 2 GCK68_14125 ENOG4107QNR UPF0135 protein GCK68_14130 ENOG4107RF4 Phosphodiesterase GCK68_14135 ENOG4105CVP deoxyribo-dipyrimidine photolyase GCK68_14140 ENOG4107SEY Conserved Protein GCK68_14150 ENOG4105XIQ Protein of unknown function (DUF2517) GCK68_14180 ENOG4105C08 Histidine kinase GCK68_14185 ENOG4105EEX Two component transcriptional regulator (Winged helix family GCK68_14200 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GCK68_14225 ENOG4105EZV Transcriptional regulator GCK68_14230 ENOG4105VCP PTS System GCK68_14235 ENOG4105CK1 PTS System GCK68_14240 ENOG4105VZJ PTS System GCK68_14250 ENOG41085Q9 Protein CrcB homolog GCK68_14255 ENOG41086WQ Protein CrcB homolog GCK68_14260 ENOG4107SVH Potassium channel protein GCK68_14265 ENOG4105XXV Acid-resistance protein GCK68_14285 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GCK68_14315 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) GCK68_14320 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GCK68_14325 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GCK68_14330 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GCK68_14335 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GCK68_14340 ENOG4105VEQ Cold shock protein GCK68_14350 ENOG4108SAJ Protein of unknown function (DUF1198) GCK68_14355 ENOG4108WMJ Protein of unknown function (DUF2002) GCK68_14380 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GCK68_14385 ENOG4108IJ7 Glycine betaine GCK68_14390 ENOG4108HQS Glycine betaine GCK68_14395 ENOG4105GIJ Glycine betaine GCK68_14435 ENOG4105EV9 Alpha Beta Hydrolase GCK68_14440 ENOG4105NNH LexA regulated protein GCK68_14450 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GCK68_14455 ENOG41090R7 Ferric uptake GCK68_14480 ENOG4108RS6 transposase GCK68_14485 ENOG4105CI1 PTS System GCK68_14495 ENOG4105CE4 GlcNAc 6-P deacetylase GCK68_14500 ENOG4105E2R ROK family GCK68_14505 ENOG4105D4U had-superfamily hydrolase, subfamily iia GCK68_14510 ENOG4105CAQ asparagine synthetase GCK68_14550 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GCK68_14560 ENOG4105C9A Phoh family GCK68_14570 ENOG4108JU5 Magnesium and cobalt efflux protein GCK68_14575 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GCK68_14580 ENOG4107RP9 extracellular solute-binding protein, family 3 GCK68_14585 ENOG4105EAD ABC transporter GCK68_14590 ENOG4105DRP amino acid AbC transporter GCK68_14595 ENOG4105CDA abc transporter atp-binding protein GCK68_14600 ENOG4107PAI alpha helical protein GCK68_14615 ENOG4105DJF DNA polymerase III, delta' subunit GCK68_14625 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GCK68_14635 ENOG4105CJN penicillin-binding protein GCK68_14640 ENOG4105CNI cell division protein FtsW GCK68_14645 ENOG4105K6T rare lipoprotein A GCK68_14650 ENOG4105DZ1 carboxypeptidase GCK68_14675 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) GCK68_14680 ENOG4107Z6W Protein CrcB homolog GCK68_14685 ENOG4105VEQ Cold shock protein GCK68_14695 ENOG4108N8T regulatoR GCK68_14720 ENOG4108JJ7 ABC transporter GCK68_14730 ENOG4105DH8 myo-inositol catabolism GCK68_14740 ENOG4105EDK PfkB domain protein GCK68_14745 ENOG4105CK5 oxidoreductase GCK68_14750 ENOG4105CNN ABC, transporter GCK68_14755 ENOG4105C2J ABC transporter GCK68_14760 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GCK68_14770 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GCK68_14775 ENOG4105C26 Dehydrogenase GCK68_14790 ENOG4105DN3 alpha-2-macroglobulin domain protein GCK68_14795 ENOG4108RS6 transposase GCK68_14800 ENOG4108JQB penicillin-binding protein 1C GCK68_14805 ENOG4105HVQ Regulatory factor of maltose metabolism GCK68_14825 ENOG4108WC9 type VI secretion system effector, hcp1 family GCK68_14875 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GCK68_14890 ENOG4107SET aldo keto reductase GCK68_14895 ENOG4105EQ2 LysR family Transcriptional regulator GCK68_14925 ENOG41077RS Phosphatase GCK68_14930 ENOG4105E8V Alpha Beta Hydrolase Fold protein GCK68_14940 ENOG4108HPI phosphatidate Cytidylyltransferase GCK68_14945 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase GCK68_14960 ENOG4108KU3 Integrase GCK68_14995 ENOG4105WQ3 Rna-binding protein GCK68_15000 ENOG4108RS6 transposase GCK68_15010 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GCK68_15025 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GCK68_15030 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GCK68_15035 ENOG4105CV6 ABC transporter, permease GCK68_15040 ENOG4108I0Y (ABC) transporter GCK68_15045 ENOG4108UJV acyl-CoA thioesterase i GCK68_15050 ENOG4105E1F short-chain dehydrogenase reductase GCK68_15055 ENOG4107QR8 Thioredoxin GCK68_15060 ENOG4107QX8 SPFH domain, Band 7 family protein GCK68_15065 ENOG4105G5H Membrane GCK68_15070 ENOG4108Z6Z Transcriptional regulator GCK68_15075 ENOG4105C59 p-type ATPase GCK68_15080 ENOG4105MBR gumn family GCK68_15085 ENOG4108Z66 YbaK ebsC protein GCK68_15100 ENOG4105EU0 Major facilitator Superfamily GCK68_15105 ENOG4105CKD glutathione-regulated potassium-efflux system protein GCK68_15110 ENOG4107RE1 Inosine-guanosine kinase GCK68_15115 ENOG4108QY5 Ferric enterobactin transport protein GCK68_15130 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GCK68_15135 ENOG4105C30 Nad-dependent epimerase dehydratase GCK68_15145 ENOG4108TJN glycosyl transferase group 1 GCK68_15185 ENOG4108SMP Nad-dependent epimerase dehydratase GCK68_15190 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GCK68_15195 ENOG4105FAW cDP-glucose 4,6-dehydratase GCK68_15200 ENOG4105FAW cDP-glucose 4,6-dehydratase GCK68_15205 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GCK68_15210 ENOG4108EX3 reductase GCK68_15240 ENOG4107QMP dna polymerase iii subunits gamma and tau GCK68_15250 ENOG4105WD1 Membrane GCK68_15260 ENOG4106428 Protein of unknown function (DUF2496) GCK68_15265 ENOG4105EGS Mechanosensitive ion channel GCK68_15270 ENOG41090EX DsrE family GCK68_15275 ENOG4108IG5 Transcriptional regulator GCK68_15280 ENOG4105C1P efflux transporter, rnd family, mfp subunit GCK68_15285 ENOG4105BZS acriflavin resistance protein GCK68_15295 ENOG4105YK5 50S ribosomal protein L36 GCK68_15305 ENOG4108UKR Biofilm formation regulator YbaJ GCK68_15310 ENOG4105KF5 hemolysin expression-modulating protein GCK68_15320 ENOG41080UX Methyltransferase GCK68_15325 ENOG4108MNP Glycoprotein polysaccharide metabolism GCK68_15330 ENOG4105C29 acyl-CoA thioesterase GCK68_15335 ENOG4105BZU Histidine kinase GCK68_15340 ENOG4108YZA Nitrogen regulatory protein pii GCK68_15345 ENOG4105BZ1 (ABC) transporter GCK68_15350 ENOG4105BZ1 (ABC) transporter GCK68_15355 ENOG4108XM1 transcriptional regulator AsnC family GCK68_15360 ENOG4105C6T cysteine synthase GCK68_15370 ENOG4108NFA extracellular solute-binding protein GCK68_15380 ENOG4108TGP Thioesterase superfamily protein GCK68_15385 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GCK68_15390 ENOG4105EIN peptidylprolyl cis-trans isomerase GCK68_15395 ENOG4105K70 DNA-binding protein GCK68_15400 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GCK68_15425 ENOG4105M85 Bola protein GCK68_15430 ENOG4105IEY (LipO)protein GCK68_15435 ENOG4105EYM Major Facilitator superfamily GCK68_15440 ENOG4108NFH Sugar hydrolase GCK68_15445 ENOG4105E2S oxidase) subunit II GCK68_15450 ENOG4105BZ9 Cytochrome C oxidase, subunit I GCK68_15455 ENOG4105CCU oxidase (Subunit III) GCK68_15460 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) GCK68_15470 ENOG4107RDB Major Facilitator GCK68_15485 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GCK68_15490 ENOG4107S0N DJ-1 family GCK68_15505 ENOG4105CTB Polyprenyl synthetase GCK68_15515 ENOG4108RS6 transposase GCK68_15520 ENOG4108ZAI phosphatidylglycerophosphatase a GCK68_15525 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GCK68_15540 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GCK68_15565 ENOG4108RS6 transposase GCK68_15570 ENOG4108RS6 transposase GCK68_15575 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GCK68_15580 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GCK68_15585 ENOG4105VIE preprotein translocase, subunit YajC GCK68_15595 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GCK68_15600 ENOG4108ZYK Acyl carrier protein phosphodiesterase GCK68_15605 ENOG4105D3R alkyl hydroperoxide reductase GCK68_15620 ENOG4105CHR reductase GCK68_15630 ENOG4107R28 alpha amylase, catalytic region GCK68_15635 ENOG4105C85 amino acid GCK68_15640 ENOG4105CWM branched-chain amino acid transport system II carrier protein GCK68_15650 ENOG4105BZU Histidine kinase GCK68_15655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GCK68_15660 ENOG4107RH8 nuclease SbcCD subunit D GCK68_15665 ENOG4105EYH Exonuclease GCK68_15670 ENOG4105DKQ ROK family GCK68_15700 ENOG4105F2W methyltransferase GCK68_15750 ENOG4108KB2 LysR family Transcriptional regulator GCK68_15755 ENOG4105CIN aminoacyl-histidine dipeptidase GCK68_15775 ENOG4105CJ2 (LipO)protein GCK68_15795 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GCK68_15800 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GCK68_15805 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GCK68_15815 ENOG4105F7V ErfK ybiS ycfS ynhG family protein GCK68_15820 ENOG4105E7A Glutamine amidotransferase GCK68_15830 ENOG4107QPN acyl-Coa dehydrogenase GCK68_15840 ENOG4106YJS accessory processing protein GCK68_15865 ENOG4105C5R Aminotransferase GCK68_15880 ENOG4105C5R Aminotransferase GCK68_15890 ENOG4105E5Q amino acid AbC transporter GCK68_15930 ENOG4105EQ0 Major Facilitator superfamily GCK68_15935 ENOG4108UMN azlc family GCK68_15940 ENOG4105ZED uncharacterized protein ygaH GCK68_15945 ENOG4105NTK Transcriptional repressor Mpra GCK68_15950 ENOG4105CW7 secretion protein, HlyD family GCK68_15955 ENOG4105C0R drug resistance transporter emrb qaca subfamily GCK68_15960 ENOG4105EIB trna rrna methyltransferase GCK68_15965 ENOG4105K63 Thioredoxin GCK68_15970 ENOG4106IUH DTW domain containing protein GCK68_15975 ENOG4105CD5 CoA-binding domain protein GCK68_15980 ENOG4105JIM Phosphatidylserine synthase GCK68_15985 ENOG4105T42 (LipO)protein GCK68_16025 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GCK68_16030 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GCK68_16035 ENOG4105C34 Pseudouridine synthase GCK68_16045 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GCK68_16050 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GCK68_16055 ENOG4108RS6 transposase GCK68_16080 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GCK68_16085 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GCK68_16090 ENOG4108NEV two component transcriptional regulator, LytTR family GCK68_16100 ENOG4108NE3 Salt-induced outer membrane protein GCK68_16105 ENOG4108RS6 transposase GCK68_16130 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GCK68_16135 ENOG4106KVJ cytochrome C assembly protein GCK68_16140 ENOG4108JU6 CBS domain protein GCK68_16145 ENOG4108RS6 transposase GCK68_16155 ENOG4105D9M gamma-glutamylcysteine synthetase GCK68_16160 ENOG4105W39 Membrane GCK68_16165 ENOG4107VXZ Hydrolase GCK68_16195 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GCK68_16200 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GCK68_16240 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GCK68_16245 ENOG4108IUS Transketolase GCK68_16250 ENOG4108HHA Transketolase GCK68_16255 ENOG4105CNN ABC, transporter GCK68_16260 ENOG4105C2J ABC transporter GCK68_16280 ENOG4108XVM Cytochrome b(562) GCK68_16285 ENOG4105CPW cytochrome b561 GCK68_16290 ENOG4108NEM leader-binding protein dmsD GCK68_16295 ENOG4107KGK dmso reductase anchor subunit GCK68_16300 ENOG4105QAX Iron-sulfur GCK68_16305 ENOG4107QY8 reductase GCK68_16310 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GCK68_16315 ENOG4105E98 transcriptional regulator DeoR family GCK68_16325 ENOG4108RS6 transposase GCK68_16330 ENOG4105C2J ABC transporter GCK68_16335 ENOG4105CNN ABC, transporter GCK68_16340 ENOG4105F5R ABC transporter GCK68_16345 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase GCK68_16350 ENOG4105CMG Carbohydrate kinase GCK68_16355 ENOG4107GFK fumarate GCK68_16365 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GCK68_16375 ENOG4105D05 Receptor GCK68_16385 ENOG4105CA0 peroxidase GCK68_16390 ENOG4105E89 ABC transporter GCK68_16415 ENOG4105DKT Transcriptional regulator GCK68_16425 ENOG4105CMT Dihydroxyacetone kinase GCK68_16430 ENOG4105CHR reductase GCK68_16435 ENOG4105CPQ Dehydrogenase GCK68_16440 ENOG4108YZG isomerase GCK68_16445 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GCK68_16450 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GCK68_16455 ENOG4108K5P (LipO)protein GCK68_16480 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GCK68_16490 ENOG4105N0Z inner membrane protein ygbE GCK68_16495 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GCK68_16550 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GCK68_16555 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GCK68_16575 ENOG4105DXN mazG family GCK68_16580 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GCK68_16585 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GCK68_16595 ENOG4105BZU Histidine kinase GCK68_16600 ENOG4105C0H protease GCK68_16610 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GCK68_16620 ENOG4105EN6 Membrane GCK68_16640 ENOG4105S6R Iron-hydroxamate transporter permease subunit GCK68_16645 ENOG4105J76 Periplasmic binding protein GCK68_16650 ENOG4105E0A ABC, transporter GCK68_16655 ENOG4105BZ4 penicillin-binding protein GCK68_16660 ENOG4105CQ7 ATP-dependent helicase GCK68_16665 ENOG4107XID 2'-5' rna ligase GCK68_16675 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GCK68_16685 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GCK68_16690 ENOG4105DJ0 Poly(A) Polymerase GCK68_16695 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GCK68_16720 ENOG4105E3A (ABC) transporter GCK68_16725 ENOG4105DA5 (ABC) transporter GCK68_16730 ENOG41077A9 carbonic anhydrase GCK68_16735 ENOG4108UGV hypoxanthine phosphoribosyltransferase GCK68_16740 ENOG4105E3B Multicopper oxidase GCK68_16745 ENOG4108ZRK uncharacterized protein yacC GCK68_16760 ENOG4105RPH Inner membrane protein YddG GCK68_16770 ENOG4107QIJ Aconitate hydratase 2 GCK68_16775 ENOG4108RS6 transposase GCK68_16780 ENOG4107QN2 dihydrolipoyl dehydrogenase GCK68_16785 ENOG4107QSN dihydrolipoamide acetyltransferase GCK68_16790 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GCK68_16795 ENOG41073TP transcriptional regulator GCK68_16805 ENOG4105C85 amino acid GCK68_16810 ENOG4106A72 regulatory protein AmpE GCK68_16815 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GCK68_16820 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GCK68_16825 ENOG4108ZUW Major pilin subunit GCK68_16830 ENOG4107QHF type ii secretion system protein e GCK68_16835 ENOG4105D7Q type ii secretion system GCK68_16850 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GCK68_16865 ENOG4108RS6 transposase GCK68_16880 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GCK68_16900 ENOG4108K5H permease YjgP YjgQ family protein GCK68_16905 ENOG4108M8S permease YjgP YjgQ family protein GCK68_16915 ENOG4105MYG DNA polymerase iii, chi subunit GCK68_16920 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GCK68_16925 ENOG4108MJ3 acetyltransferase GCK68_16930 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) GCK68_16935 ENOG4105DBV ornithine carbamoyltransferase GCK68_16940 ENOG4105XEP YhcH YjgK YiaL family protein GCK68_16950 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GCK68_16955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GCK68_16960 ENOG4105C3U ABC transporter GCK68_16965 ENOG4108JQ7 (ABC) transporter GCK68_16970 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GCK68_16975 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GCK68_16980 ENOG4107RJJ Transcriptional regulator GCK68_16985 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG GCK68_16990 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH GCK68_16995 ENOG4105EKV Phosphonate metabolism protein GCK68_17000 ENOG4105FT8 Phosphonate metabolism GCK68_17005 ENOG4105ENV phosphonate C-P lyase system protein PhnK GCK68_17010 ENOG4105HRV phosphonate c-p lyase system protein phnl GCK68_17015 ENOG4105FD8 phosphonate metabolism protein PhnM GCK68_17020 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) GCK68_17025 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein GCK68_17030 ENOG4105K4T epimerase GCK68_17050 ENOG4105DRS transport system, permease GCK68_17055 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GCK68_17080 ENOG4108YYD acetyltransferase GCK68_17085 ENOG4105XPQ lipid carrier protein GCK68_17095 ENOG4105CFP Peptidase U32 GCK68_17100 ENOG4106RZ4 Peptidase U32 GCK68_17105 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GCK68_17110 ENOG4105BZS acriflavin resistance protein GCK68_17120 ENOG4105DEN Luciferase family GCK68_17145 ENOG4105C1J atp-dependent rna helicase GCK68_17190 ENOG4105CHV Transcription elongation factor NusA GCK68_17220 ENOG4105EEI dihydropteroate synthase GCK68_17225 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GCK68_17235 ENOG4105HBR Rna-binding protein GCK68_17240 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GCK68_17245 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase GCK68_17265 ENOG4105QYV Membrane GCK68_17280 ENOG4105EAH synthase GCK68_17290 ENOG4105HVQ Regulatory factor of maltose metabolism GCK68_17315 ENOG4105DFU Cell wall formation (By similarity) GCK68_17325 ENOG4105F0N pyrophosphate phospho-hydrolase GCK68_17330 ENOG4108ZHD aig2 family GCK68_17335 ENOG4105MA0 exported protein GCK68_17340 ENOG4105CFU surface antigen GCK68_17350 ENOG4105C37 (CBS) domain GCK68_17355 ENOG41061GZ Protein of unknown function (DUF1107) GCK68_17360 ENOG4108UUE Transcriptional regulator GCK68_17365 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GCK68_17370 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GCK68_17380 ENOG4108V1T peptidylprolyl cis-trans isomerase GCK68_17385 ENOG4105FHY Opacity-associated protein A GCK68_17395 ENOG4108RS6 transposase GCK68_17405 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GCK68_17415 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GCK68_17425 ENOG4108MXZ Esterase GCK68_17445 ENOG4105WSB biofilm stress and motility protein A GCK68_17450 ENOG4105CSU acyl-Coa dehydrogenase GCK68_17455 ENOG4105C2N RNA methyltransferase TrmH family group 3 GCK68_17460 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GCK68_17480 ENOG4105EPW hflc protein GCK68_17485 ENOG4107QJR hflk protein GCK68_17490 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GCK68_17510 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GCK68_17515 ENOG4105K8N protein family UPF0079, ATPase GCK68_17520 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GCK68_17525 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GCK68_17545 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GCK68_17565 ENOG4105EGS Mechanosensitive ion channel GCK68_17595 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GCK68_17600 ENOG4105KPY Small multidrug resistance protein GCK68_17610 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GCK68_17615 ENOG4108ZVF (LipO)protein GCK68_17660 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GCK68_17665 ENOG4108RC0 Electron transport protein GCK68_17670 ENOG4105BZ8 glutamate synthase GCK68_17680 ENOG4108SIC Transcriptional regulator GCK68_17750 ENOG4105C0A alcohol dehydrogenase GCK68_17760 ENOG4108UUM single-stranded DNA-binding protein GCK68_17765 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GCK68_17770 ENOG4105MSB protein, conserved in bacteria GCK68_17775 ENOG4105CGF Aromatic amino acid aminotransferase GCK68_17780 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GCK68_17785 ENOG4105CDU Replicative dna helicase GCK68_17790 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GCK68_17795 ENOG4105P4Z Phage shock protein G GCK68_17800 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GCK68_17805 ENOG4105MYN Zinc uptake regulation protein GCK68_17815 ENOG41080IJ Diacylglycerol kinase GCK68_17870 ENOG4108S1B Periplasmic chaperone protein GCK68_17930 ENOG4105DAX Pfam:DUF2983 GCK68_17950 ENOG4105D4P Coproporphyrinogen iii oxidase GCK68_17955 ENOG41090JE Utilization Protein GCK68_17970 ENOG4107ENK receptor GCK68_17975 ENOG4106QJH hemin transport protein GCK68_17980 ENOG4107R4I Periplasmic binding protein GCK68_17985 ENOG4105EHG Permease protein GCK68_17995 ENOG4105C28 cystathionine GCK68_18000 ENOG4105C44 Serine transporter GCK68_18005 ENOG4105EQ2 LysR family Transcriptional regulator GCK68_18010 ENOG4105KSU Redox protein GCK68_18015 ENOG41066VF YeeE YedE family protein GCK68_18020 ENOG4108IUF type iii secretion GCK68_18025 ENOG4108TN6 type iii secretion GCK68_18030 ENOG41083GP type iii secretion GCK68_18035 ENOG4108HHI Type III secretion system protein GCK68_18040 ENOG41063Q7 Type III secretion system protein GCK68_18055 ENOG4108JIR Flagellum-specific ATP synthase GCK68_18115 ENOG4105BZU Histidine kinase GCK68_18120 ENOG4105WH1 Two component transcriptional regulator luxr family GCK68_18125 ENOG4105CK2 sodium dicarboxylate symporter GCK68_18135 ENOG41062QD Membrane GCK68_18210 ENOG4105C12 Phosphoribosylglycinamide synthetase GCK68_18215 ENOG4108T8B Protein of unknown function (DUF1481) GCK68_18225 ENOG4105R2J Conserved Protein GCK68_18230 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GCK68_18255 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GCK68_18265 ENOG4105D06 uba thif-type nad fad binding protein GCK68_18280 ENOG4105D41 biosynthesis protein thiH GCK68_18290 ENOG4108RS6 transposase GCK68_18325 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GCK68_18330 ENOG4105PM1 preprotein translocase subunit SecE GCK68_18380 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GCK68_18385 ENOG4105D4A Cell wall formation (By similarity) GCK68_18420 ENOG4108RR8 protoporphyrinogen oxidase GCK68_18425 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GCK68_18435 ENOG4108RS6 transposase GCK68_18440 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GCK68_18460 ENOG4107QK7 reductase GCK68_18470 ENOG4105MDZ Transcriptional activator rfaH GCK68_18475 ENOG4105D52 delta-aminolevulinic acid dehydratase GCK68_18500 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GCK68_18510 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GCK68_18520 ENOG4105JC1 sterol-binding domain protein GCK68_18530 ENOG4105CGY Dna recombination protein GCK68_18535 ENOG4108KF1 Membrane GCK68_18550 ENOG4108I5U Uridine phosphorylase GCK68_18555 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) GCK68_18565 ENOG4105DZ2 Transcriptional regulator GCK68_18570 ENOG4105EMK carboxylate amino acid amine transporter GCK68_18575 ENOG4105RK9 auxin efflux carrier GCK68_18580 ENOG4107T6V glycerophosphoryl diester phosphodiesterase GCK68_18640 ENOG4108IV0 ABC, transporter GCK68_18645 ENOG4105C0Z ABC transporter GCK68_18650 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GCK68_18655 ENOG4105C32 Amino acid ABC transporter (Permease) GCK68_18660 ENOG4105CP9 extracellular ligand-binding receptor GCK68_18665 ENOG4105U59 -acetyltransferase GCK68_18670 ENOG4108RS6 transposase GCK68_18680 ENOG4105CRP Part of the ABC transporter FtsEX involved in GCK68_18685 ENOG4105CAK Cell division ATP-binding protein ftsE GCK68_18690 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GCK68_18690 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GCK68_18700 ENOG4106H78 methyltransferase GCK68_18705 ENOG4105MG3 Membrane GCK68_18720 ENOG4107FS9 Membrane GCK68_18735 ENOG4105EX9 Membrane GCK68_18740 ENOG4108W1V Lipoprotein GCK68_18745 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GCK68_18755 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A GCK68_18770 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GCK68_18780 ENOG4105DQF Hydrolase GCK68_18785 ENOG4108EUD Lysophospholipase GCK68_18795 ENOG4105CCF Lysine exporter protein (Lyse ygga) GCK68_18800 ENOG4105C9U ATP-dependent DNA helicase RecQ GCK68_18805 ENOG4105HDD phospholipase GCK68_18810 ENOG4108VUY thioesterase Superfamily protein GCK68_18815 ENOG4105FR1 rard protein GCK68_18820 ENOG4107QUT magnesium and cobalt transport protein CorA GCK68_18830 ENOG4105EQN UPF0261 protein GCK68_18840 ENOG4105C4R Atp-dependent dna helicase GCK68_18845 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GCK68_18850 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GCK68_18855 ENOG4105CT0 Protein of unknown function, DUF484 GCK68_18865 ENOG4105S7Z (LipO)protein GCK68_18875 ENOG4107T0K Adenylate cyclase GCK68_18890 ENOG41076E6 Uroporphyrinogen-III Synthase GCK68_18895 ENOG4105ECF c-methyltransferase GCK68_18900 ENOG410601J HemY protein GCK68_18910 ENOG4108RS6 transposase GCK68_18935 ENOG4105C85 amino acid GCK68_18955 ENOG4105EGZ biosynthesis protein GCK68_18960 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GCK68_18965 ENOG4108WJ1 acetyltransferase GCK68_18970 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GCK68_18975 ENOG4105C1B dTDP-glucose 4-6-dehydratase GCK68_18980 ENOG4108IJ1 Dehydrogenase GCK68_18985 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GCK68_18990 ENOG4105SFE lipopolysaccharide biosynthesis protein GCK68_18995 ENOG4105ESV Glycosyl transferase, family 4 GCK68_19005 ENOG4105K63 Thioredoxin GCK68_19020 ENOG4105C4R Atp-dependent dna helicase GCK68_19030 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GCK68_19055 ENOG4105GQR Chaperone GCK68_19060 ENOG4105CW0 outer membrane usher protein GCK68_19070 ENOG4108VEV chaperone GCK68_19110 ENOG4105EMY transcriptional regulator GCK68_19145 ENOG4105C7B Threonine dehydratase GCK68_19155 ENOG4105CM2 brancheD-chain amino acid aminotransferase GCK68_19160 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit GCK68_19180 ENOG4105C0P Mg chelatase subunit ChlI GCK68_19185 ENOG4108WFC UPF0438 protein yifE GCK68_19195 ENOG41062B0 ABC transporter, permease GCK68_19200 ENOG4107R9N ABC transporter GCK68_19205 ENOG4105C2J ABC transporter GCK68_19210 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator GCK68_19270 ENOG4108Y73 Membrane GCK68_19285 ENOG4105C5Q Transcriptional regulator GCK68_19290 ENOG4105EHV domain protein GCK68_19295 ENOG4107QN2 dihydrolipoyl dehydrogenase GCK68_19300 ENOG4105YHG TonB family GCK68_19305 ENOG4107QZV Type I secretion membrane fusion protein GCK68_19320 ENOG4105X58 receptor GCK68_19335 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GCK68_19370 ENOG4105SYT Methylenetetrahydrofolate reductase GCK68_19375 ENOG4105CFH Aspartokinase GCK68_19390 ENOG4108Z12 YiaAB two helix domain-containing protein GCK68_19400 ENOG4105C25 Primosomal protein n' GCK68_19415 ENOG41063M6 Cell Division Protein GCK68_19430 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GCK68_19455 ENOG4108MBX Secretion Protein GCK68_19460 ENOG4108JJA ABC, transporter GCK68_19485 ENOG4108RS6 transposase GCK68_19505 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GCK68_19510 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GCK68_19515 ENOG4105CBT Fructose-1,6-bisphosphatase GCK68_19520 ENOG4105DP0 ferredoxin-NADP reductase GCK68_19525 ENOG4108VTS Membrane GCK68_19530 ENOG4105EBK exported protein GCK68_19540 ENOG4107F9Y LysR family transcriptional regulator GCK68_19550 ENOG4105JSC dimethylmenaquinone methyltransferase GCK68_19555 ENOG4107QPK )-transporter GCK68_19565 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GCK68_19595 ENOG4105FMW periplasmic GCK68_19600 ENOG4105E3W Two component transcriptional regulator (Winged helix family GCK68_19605 ENOG4105E0F Histidine kinase GCK68_19610 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GCK68_19615 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GCK68_19620 ENOG4105D7W serine acetyltransferase GCK68_19640 ENOG4105VW4 glutaredoxin 3 GCK68_19645 ENOG4107YZP Rhodanese domain protein GCK68_19655 ENOG41063SB peptidase GCK68_19670 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GCK68_19680 ENOG4105XA0 heptosyltransferase ii GCK68_19685 ENOG4105D16 lipopolysaccharide heptosyltransferase i GCK68_19690 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GCK68_19710 ENOG4105W0E 50S ribosomal protein L33 GCK68_19730 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GCK68_19755 ENOG4105DSJ YicC domain protein GCK68_19760 ENOG4105EN6 Membrane GCK68_19765 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) GCK68_19780 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GCK68_19785 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GCK68_19790 ENOG4105CB5 ATP-dependent DNA helicase recG GCK68_19800 ENOG4105D6U Sodium Glutamate Symporter GCK68_19805 ENOG4105C2W permease GCK68_19810 ENOG4105JV1 AsmA family GCK68_19815 ENOG4105SUU thioesterase domain GCK68_19835 ENOG4105CWB LysR family transcriptional Regulator GCK68_19840 ENOG4108CNN domain protein GCK68_19850 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GCK68_19870 ENOG4105W4M Transport-associated protein GCK68_19880 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain GCK68_19890 ENOG4105BZU Histidine kinase GCK68_19900 ENOG4105N5T Radical SAM Protein GCK68_19905 ENOG4105CBC glutamate synthase GCK68_19910 ENOG4105BZ8 glutamate synthase GCK68_19920 ENOG4105KB2 stringent starvation protein b GCK68_19925 ENOG4107MKT Stringent starvation protein a GCK68_19945 ENOG4105D6Z AFG1 family ATPase GCK68_19950 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III GCK68_19955 ENOG4105C0H protease GCK68_19960 ENOG4108RS6 transposase GCK68_19965 ENOG4105C0H protease GCK68_19975 ENOG4105VFK BolA family GCK68_19980 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane GCK68_19985 ENOG4105E3I toluene tolerance GCK68_19990 ENOG4107PE3 Mammalian cell entry related domain protein GCK68_19995 ENOG4105CY3 ABC transporter, permease GCK68_20000 ENOG4105DHJ ABC, transporter GCK68_20005 ENOG4105FEU K -dependent Na -Ca exchanger GCK68_20010 ENOG4105C2X Arabinose 5-phosphate isomerase GCK68_20015 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase GCK68_20020 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) GCK68_20025 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA GCK68_20030 ENOG4108IUZ ABC transporter GCK68_20035 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GCK68_20045 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GCK68_20060 ENOG41080Z8 PHOSPHOCARRIER protein GCK68_20080 ENOG4105KME endoribonuclease L-psp GCK68_20090 ENOG4105D4X repressor GCK68_20095 ENOG4105C5Y PTS System GCK68_20100 ENOG4105CG3 alpha amylase, catalytic region GCK68_20105 ENOG4105NXH GreA GreB family elongation factor GCK68_20110 ENOG4108XVM Cytochrome b(562) GCK68_20120 ENOG4105CMS peptidase U62, modulator of DNA gyrase GCK68_20130 ENOG4105UNR (Barnase) inhibitor GCK68_20160 ENOG4105CR8 Transcriptional regulator GCK68_20210 ENOG4105D1U peptidase U62 modulator of DNA gyrase GCK68_20220 ENOG4105QD6 exported protein GCK68_20225 ENOG4105C03 ribonuclease GCK68_20235 ENOG4105VQ7 Rod shape-determining protein MreD GCK68_20240 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GCK68_20245 ENOG4105DFF Rod shape-determining protein mreb GCK68_20250 ENOG41062P1 Diguanylate cyclase phosphodiesterase GCK68_20255 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GCK68_20260 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) GCK68_20275 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GCK68_20280 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GCK68_20285 ENOG4105RG0 Membrane GCK68_20290 ENOG4108IA2 Sodium pantothenate symporter GCK68_20300 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GCK68_20305 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) GCK68_20330 ENOG4105CSH Transporter GCK68_20335 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GCK68_20350 ENOG4108XTF Outer Membrane Lipoprotein GCK68_20360 ENOG4105VEQ Cold shock protein GCK68_20365 ENOG4105VEQ Cold shock protein GCK68_20370 ENOG4108RS6 transposase GCK68_20385 ENOG4105CYM Glutathione S-transferase GCK68_20390 ENOG4105C2X Arabinose 5-phosphate isomerase GCK68_20395 ENOG4105EF1 ribulokinase GCK68_20405 ENOG4105CNN ABC, transporter GCK68_20410 ENOG4105C2J ABC transporter GCK68_20420 ENOG4105D1S lipid A biosynthesis GCK68_20430 ENOG4105EEQ Na H antiporter GCK68_20435 ENOG4105C7N Xanthine uracil vitamin C permease GCK68_20455 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GCK68_20465 ENOG4105GVF (ABC) transporter GCK68_20475 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GCK68_20480 ENOG4108RVA ribokinase GCK68_20485 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GCK68_20490 ENOG4105W4W Transcriptional regulator GCK68_20495 ENOG4107TYG Oxidoreductase domain-containing protein GCK68_20515 ENOG4105CNA YD repeat protein GCK68_20530 ENOG4105CS6 Rhs element vgr protein GCK68_20560 ENOG4105CNA YD repeat protein GCK68_20575 ENOG4105CS6 Rhs element vgr protein GCK68_20610 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GCK68_20685 ENOG4108WC9 type VI secretion system effector, hcp1 family GCK68_20695 ENOG4107W52 maltose operon periplasmic protein GCK68_20715 ENOG4107FKK extracellular solute-binding protein family 1 GCK68_20720 ENOG4105D56 permease protein GCK68_20725 ENOG4105EG2 ABC transporter, permease GCK68_20740 ENOG4105CFH Aspartokinase GCK68_20755 ENOG4105C3R Methionine synthase GCK68_20770 ENOG4108I9X Isocitrate lyase GCK68_20775 ENOG4107QP3 malate synthase g GCK68_20825 ENOG4107EJG GntR family transcriptional regulator GCK68_20830 ENOG4105C0R drug resistance transporter emrb qaca subfamily GCK68_20845 ENOG4108RVA ribokinase GCK68_20875 ENOG4108VVK transcriptional Regulator, AsnC GCK68_20880 ENOG4105QTB Flavodoxin GCK68_20900 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation GCK68_20910 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GCK68_20955 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GCK68_20960 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GCK68_20965 ENOG4105C8U phosphate abc transporter GCK68_20970 ENOG4105E2Z phosphate ABC transporter (Permease GCK68_20990 ENOG4106PMH Extracellular solute-binding protein family 3 GCK68_20995 ENOG4105EAD ABC transporter GCK68_21000 ENOG4105DRP amino acid AbC transporter GCK68_21005 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 GCK68_21015 ENOG4105C7N Xanthine uracil vitamin C permease GCK68_21045 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GCK68_21060 ENOG4105VG0 50S ribosomal protein l34 GCK68_21075 ENOG4106JVB Replication Protein GCK68_21125 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GCK68_21135 ENOG4105C2M dna polymerase I GCK68_21165 ENOG4106J5W DNA polymerase III (alpha subunit) GCK68_21210 ENOG4108UIF Chaperone GCK68_21215 ENOG4106PHM regulatory protein GCK68_21290 ENOG4105EQR Transposase IS116 IS110 IS902 GCK68_21305 ENOG4105EKQ RNA-directed DNA polymerase GCK68_21355 ENOG4106RMF ParB family GCK68_21390 ENOG41073YN Protein of unknown function (DUF1380) GCK68_21415 ENOG4105FEQ ParB domain protein nuclease GCK68_21430 ENOG4105UZW Tail fiber assembly protein GCK68_21440 ENOG4108X9F tail fiber protein GCK68_21440 ENOG4108X9F tail fiber protein GCK68_21475 ENOG4108NYK Tape measure protein GCK68_21570 ENOG4105FA0 parb-like partition protein GCK68_21575 ENOG4105FA0 parb-like partition protein GCK68_21580 ENOG4105CB5 ATP-dependent DNA helicase recG GCK68_21630 ENOG4108RS6 transposase GCK68_21670 ENOG4105D2X ABC transporter substrate-binding protein GCK68_21730 ENOG4105XUP Phage derived protein Gp49-like (DUF891)