locus-tag	class	description
YP_0001	COG0716	FMN binding
YP_0002	COG1522	sequence-specific DNA binding
YP_0008	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YP_0010	COG0477	Major facilitator Superfamily
YP_0011	COG2186	Transcriptional regulator
YP_0012	COG3328	transposase activity
YP_0013	COG1763	Mo-molybdopterin cofactor biosynthetic process
YP_0015	COG3084	Protein conserved in bacteria
YP_0016	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
YP_0017	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YP_0018	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YP_0018	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YP_0019	COG1943	Transposase
YP_0022	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YP_0024	COG3852	Histidine kinase
YP_0025	COG0174	glutamine synthetase
YP_0028	COG1011	Hydrolase
YP_0029	COG1295	ribonuclease BN
YP_0033	COG0456	acetyltransferase
YP_0034	COG2982	Protein involved in outer membrane biogenesis
YP_0035	COG2233	PERMEase
YP_0036	COG0786	glutamate:sodium symporter activity
YP_0037	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YP_0038	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YP_0039	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YP_0042	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YP_0043	COG2860	membrane
YP_0044	COG1561	YicC-like family, N-terminal region
YP_0049	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YP_0052	COG0267	Belongs to the bacterial ribosomal protein bL33 family
YP_0056	COG1519	Transferase
YP_0057	COG0859	PFAM glycosyl transferase family 9
YP_0058	COG0859	PFAM glycosyl transferase family 9
YP_0060	COG0156	8-amino-7-oxononanoate synthase activity
YP_0063	COG4942	peptidase
YP_0065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YP_0066	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YP_0070	COG1045	serine acetyltransferase
YP_0071	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
YP_0072	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YP_0072	COG2169	Transcriptional regulator
YP_0073	COG2205	protein histidine kinase activity
YP_0074	COG0745	RESPONSE REGULATOR receiver
YP_0075	COG3678	ATP-independent chaperone mediated protein folding
YP_0081	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
YP_0083	COG0471	metal ion transport
YP_0087	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YP_0088	COG0583	DNA-binding transcription factor activity
YP_0091	COG3152	Membrane
YP_0093	COG1494	fructose-1,6-bisphosphatase
YP_0094	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YP_0095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YP_0098	COG1943	Transposase
YP_0106	COG1575	Belongs to the MenA family. Type 1 subfamily
YP_0109	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YP_0110	COG1609	Transcriptional regulator
YP_0111	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YP_0113	COG4682	membrane
YP_0117	COG0626	cystathionine gamma-synthase activity
YP_0118	COG0527	aspartate kinase activity
YP_0118	COG0460	homoserine dehydrogenase
YP_0120	COG2801	Transposase and inactivated derivatives
YP_0122	COG1349	DNA-binding transcription factor activity
YP_0127	COG1640	4-alpha-glucanotransferase
YP_0134	COG1918	ferrous iron import across plasma membrane
YP_0135	COG2183	response to ionizing radiation
YP_0136	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_0137	COG0745	RESPONSE REGULATOR receiver
YP_0141	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
YP_0142	COG1011	Hydrolase
YP_0145	COG0494	nUDIX hydrolase
YP_0146	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
YP_0152	COG4796	Type ii and iii secretion system protein
YP_0157	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
YP_0158	COG0546	phosphoglycolate phosphatase activity
YP_0159	COG0180	Tryptophanyl-tRNA synthetase
YP_0162	COG2146	nitrite reductase [NAD(P)H] activity
YP_0163	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YP_0164	COG0402	S-adenosylhomocysteine deaminase activity
YP_0169	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YP_0170	COG0433	COG0433 Predicted ATPase
YP_0173	COG1289	transmembrane transporter activity
YP_0175	COG1765	OsmC-like protein
YP_0177	COG3954	Phosphoribulokinase
YP_0179	COG0429	hydrolase of the alpha beta-hydrolase fold
YP_0181	COG4521	taurine ABC transporter
YP_0183	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YP_0184	COG2175	clavaminate synthase activity
YP_0186	COG1216	Glycosyl transferase, family 2
YP_0187	COG0488	(ABC) transporter
YP_0188	COG2249	NAD(P)H dehydrogenase (quinone) activity
YP_0190	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
YP_0191	COG1047	Peptidyl-prolyl cis-trans
YP_0194	COG0545	Peptidyl-prolyl cis-trans isomerase
YP_0195	COG2964	Protein conserved in bacteria
YP_0199	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
YP_0200	COG0049	tRNA binding
YP_0203	COG1943	Transposase
YP_0206	COG0051	transcription antitermination factor activity, RNA binding
YP_0211	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_0213	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YP_0214	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YP_0216	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
YP_0217	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YP_0225	COG1841	ribosomal large subunit assembly
YP_0227	COG0201	protein transport
YP_0228	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YP_0231	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YP_0234	COG0789	Transcriptional regulator
YP_0235	COG3036	rescue of stalled ribosome
YP_0237	COG0569	domain protein
YP_0241	COG0758	DNA mediated transformation
YP_0243	COG0551	DNA topoisomerase type I activity
YP_0246	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YP_0248	COG2801	Transposase and inactivated derivatives
YP_0251	COG1943	Transposase
YP_0254	COG0237	dephospho-CoA kinase activity
YP_0257	COG1459	type II secretion system
YP_0258	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YP_0259	COG4969	Belongs to the N-Me-Phe pilin family
YP_0261	COG3023	N-Acetylmuramoyl-L-alanine amidase
YP_0262	COG3725	Membrane protein required for beta-lactamase induction
YP_0263	COG1113	amino acid transport
YP_0264	COG2186	Transcriptional regulator
YP_0265	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
YP_0266	COG0508	dehydrogenase complex catalyzes the overall conversion of
YP_0268	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YP_0269	COG1943	Transposase
YP_0270	COG1049	propionate catabolic process, 2-methylcitrate cycle
YP_0272	COG0697	spore germination
YP_0276	COG2132	Multicopper oxidase
YP_0277	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
YP_0278	COG0288	reversible hydration of carbon dioxide
YP_0279	COG1131	(ABC) transporter
YP_0280	COG0842	Transport permease protein
YP_0285	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YP_0286	COG0617	tRNA 3'-terminal CCA addition
YP_0287	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YP_0288	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
YP_0290	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
YP_0291	COG1643	Atp-dependent helicase
YP_0292	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YP_0293	COG1120	ATPase activity
YP_0294	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YP_0295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YP_0299	COG2860	membrane
YP_0301	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YP_0303	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YP_0304	COG3437	response regulator, receiver
YP_0304	COG4999	Histidine kinase
YP_0304	COG3850	Histidine kinase
YP_0304	COG2205	protein histidine kinase activity
YP_0306	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YP_0308	COG3956	TIGRFAM MazG family protein
YP_0312	COG0602	queuosine metabolic process
YP_0313	COG0720	synthase
YP_0323	COG0529	Catalyzes the synthesis of activated sulfate
YP_0326	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
YP_0331	COG4942	peptidase
YP_0331	COG1388	LysM domain
YP_0332	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YP_0333	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
YP_0334	COG0698	ribose 5-phosphate isomerase
YP_0335	COG1063	alcohol dehydrogenase
YP_0336	COG1028	Short-chain dehydrogenase reductase Sdr
YP_0337	COG2376	Dihydroxyacetone kinase
YP_0340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YP_0344	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YP_0345	COG1858	cytochrome C peroxidase
YP_0347	COG4771	TonB-dependent receptor
YP_0350	COG0024	Methionine aminopeptidase
YP_0352	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
YP_0352	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
YP_0353	COG1070	Carbohydrate kinase
YP_0354	COG3623	hexulose-6-phosphate isomerase
YP_0355	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_0356	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_0357	COG1129	ABC transporter
YP_0359	COG1349	DNA-binding transcription factor activity
YP_0360	COG0235	Class ii aldolase
YP_0361	COG0243	molybdopterin cofactor binding
YP_0362	COG0437	4 iron, 4 sulfur cluster binding
YP_0363	COG3302	dmso reductase anchor subunit
YP_0364	COG3381	protein complex oligomerization
YP_0365	COG3038	cytochrome b561
YP_0366	COG3783	Cytochrome b(562)
YP_0370	COG1129	ABC transporter
YP_0371	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_0372	COG3959	Transketolase, thiamine diphosphate binding domain
YP_0373	COG3958	Transketolase
YP_0374	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YP_0381	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YP_0382	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
YP_0383	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YP_0384	COG1238	metal cluster binding
YP_0385	COG2918	glutathione biosynthetic process
YP_0387	COG4536	flavin adenine dinucleotide binding
YP_0388	COG4137	Cytochrome C assembly protein
YP_0389	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YP_0395	COG3137	Salt-induced outer membrane protein
YP_0397	COG3279	Response regulator of the LytR AlgR family
YP_0398	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YP_0399	COG0287	Prephenate dehydrogenase
YP_0399	COG1605	Chorismate mutase
YP_0400	COG0077	Prephenate dehydratase
YP_0400	COG1605	Chorismate mutase
YP_0405	COG3162	membrane
YP_0407	COG1301	dicarboxylic acid transport
YP_0429	COG2391	methyltransferase activity
YP_0430	COG0425	Belongs to the sulfur carrier protein TusA family
YP_0431	COG0583	DNA-binding transcription factor activity
YP_0432	COG0814	amino acid
YP_0433	COG0626	cystathionine gamma-synthase activity
YP_0435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YP_0436	COG4558	Periplasmic binding protein
YP_0437	COG3720	iron ion transport
YP_0438	COG4771	TonB-dependent receptor
YP_0440	COG0702	epimerase
YP_0441	COG3721	Heme iron utilization protein
YP_0448	COG1358	cellular component organization or biogenesis
YP_0460	COG3121	Chaperone
YP_0469	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
YP_0471	COG0735	belongs to the Fur family
YP_0472	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YP_0475	COG0305	Participates in initiation and elongation during chromosome replication
YP_0476	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YP_0477	COG1448	Aminotransferase
YP_0478	COG2315	Protein conserved in bacteria
YP_0479	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_0480	COG0629	single-stranded DNA binding
YP_0482	COG1454	alcohol dehydrogenase
YP_0494	COG1309	transcriptional regulator
YP_0496	COG0493	'glutamate synthase
YP_0496	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YP_0497	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YP_0498	COG3383	formate dehydrogenase (NAD+) activity
YP_0501	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YP_0511	COG2076	Multidrug Resistance protein
YP_0512	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
YP_0514	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
YP_0515	COG1053	succinate dehydrogenase
YP_0518	COG1511	domain protein
YP_0518	COG3264	Mechanosensitive ion channel
YP_0521	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
YP_0523	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
YP_0524	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YP_0524	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
YP_0525	COG0802	atpase or kinase
YP_0526	COG0860	N-Acetylmuramoyl-L-alanine amidase
YP_0530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YP_0531	COG0330	HflC and HflK could
YP_0532	COG0330	HflC and HflK could
YP_0533	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
YP_0536	COG0557	exoribonuclease II activity
YP_0537	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YP_0538	COG1960	acyl-CoA dehydrogenase activity
YP_0540	COG1073	alpha beta
YP_0542	COG0360	Binds together with S18 to 16S ribosomal RNA
YP_0544	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
YP_0548	COG1943	Transposase
YP_0550	COG3061	Opacity-associated protein A
YP_0551	COG0545	Peptidyl-prolyl cis-trans isomerase
YP_0553	COG0737	Belongs to the 5'-nucleotidase family
YP_0555	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
YP_0557	COG1253	flavin adenine dinucleotide binding
YP_0559	COG0729	surface antigen
YP_0560	COG2911	Protein conserved in bacteria
YP_0561	COG2105	PFAM AIG2 family protein
YP_0562	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YP_0564	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YP_0568	COG3423	Transcriptional regulator
YP_0570	COG0142	geranyltranstransferase activity
YP_0573	COG0697	spore germination
YP_0575	COG0642	Histidine kinase
YP_0576	COG0745	RESPONSE REGULATOR receiver
YP_0577	COG2027	D-alanyl-D-alanine carboxypeptidase
YP_0578	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_0579	COG1534	Rna-binding protein
YP_0581	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YP_0582	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YP_0584	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
YP_0586	COG0195	Participates in both transcription termination and antitermination
YP_0592	COG2801	Transposase and inactivated derivatives
YP_0595	COG0513	Belongs to the DEAD box helicase family
YP_0599	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YP_0601	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YP_0607	COG3153	acetyltransferase
YP_0611	COG1653	transport
YP_0613	COG0395	ABC-type sugar transport system, permease component
YP_0617	COG0702	epimerase
YP_0618	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YP_0619	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
YP_0620	COG3454	Phosphonate metabolism
YP_0621	COG4778	phosphonate C-P lyase system protein PhnL
YP_0623	COG4107	phosphonate C-P lyase system protein PhnK
YP_0624	COG3627	carbon phosphorus lyase activity
YP_0625	COG3626	phosphonate metabolism
YP_0626	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
YP_0627	COG3624	Phosphonate C-P lyase system protein PhnG
YP_0628	COG2188	Transcriptional regulator
YP_0632	COG4608	Belongs to the ABC transporter superfamily
YP_0633	COG0444	Belongs to the ABC transporter superfamily
YP_0634	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YP_0635	COG0601	transmembrane transport
YP_0637	COG2731	YhcH YjgK YiaL family protein
YP_0638	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YP_0639	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
YP_0641	COG0525	valine-tRNA ligase activity
YP_0642	COG2927	DNA polymerase III (CHI subunit)
YP_0644	COG0795	lipopolysaccharide-transporting ATPase activity
YP_0645	COG0795	lipopolysaccharide-transporting ATPase activity
YP_0646	COG0582	viral genome integration into host DNA
YP_0651	COG1943	Transposase
YP_0652	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
YP_0653	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YP_0654	COG0564	pseudouridine synthase activity
YP_0656	COG0542	response to heat
YP_0657	COG5544	Lipoprotein
YP_0658	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YP_0659	COG0045	succinate-CoA ligase (ADP-forming) activity
YP_0659	COG1042	CoA-binding domain protein
YP_0659	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YP_0661	COG3118	belongs to the thioredoxin family
YP_0662	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YP_0663	COG2814	Major facilitator Superfamily
YP_0664	COG1566	PFAM secretion protein HlyD family protein
YP_0666	COG1846	Transcriptional regulator
YP_0668	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
YP_0669	COG2814	Major facilitator Superfamily
YP_0686	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
YP_0688	COG1960	acyl-CoA dehydrogenase activity
YP_0690	COG0121	glutamine amidotransferase
YP_0691	COG3034	peptidoglycan biosynthetic process
YP_0693	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YP_0694	COG1805	sodium ion transport
YP_0695	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YP_0699	COG1477	protein flavinylation
YP_0703	COG2195	Cleaves the N-terminal amino acid of tripeptides
YP_0705	COG0583	DNA-binding transcription factor activity
YP_0717	COG2226	methyltransferase
YP_0724	COG1940	carbohydrate kinase activity
YP_0725	COG0419	ATPase involved in DNA repair
YP_0726	COG0420	3'-5' exonuclease activity
YP_0727	COG0745	RESPONSE REGULATOR receiver
YP_0728	COG5002	protein histidine kinase activity
YP_0730	COG1114	Component of the transport system for branched-chain amino acids
YP_0732	COG0366	Alpha amylase catalytic
YP_0737	COG0450	alkyl hydroperoxide reductase
YP_0738	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
YP_0739	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
YP_0741	COG1862	Preprotein translocase
YP_0742	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YP_0743	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YP_0744	COG1943	Transposase
YP_0748	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YP_0748	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YP_0751	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
YP_0752	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
YP_0753	COG1943	Transposase
YP_0755	COG0142	geranyltranstransferase activity
YP_0759	COG0693	protein deglycase activity
YP_0760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
YP_0762	COG2814	Major facilitator Superfamily
YP_0764	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
YP_0765	COG1845	cytochrome c oxidase, subunit III
YP_0766	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YP_0767	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YP_0769	COG2223	nitrite transmembrane transporter activity
YP_0770	COG3056	Lipoprotein
YP_0771	COG0271	Belongs to the BolA IbaG family
YP_0776	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YP_0777	COG0776	regulation of translation
YP_0778	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YP_0779	COG1555	photosystem II stabilization
YP_0780	COG0824	Thioesterase
YP_0782	COG4533	DNA binding
YP_0785	COG1522	sequence-specific DNA binding
YP_0786	COG1132	(ABC) transporter
YP_0787	COG1132	(ABC) transporter
YP_0788	COG0347	Belongs to the P(II) protein family
YP_0789	COG0004	ammonium transporteR
YP_0790	COG1946	Acyl-CoA thioesterase
YP_0791	COG3126	Type III secretion system lipoprotein chaperone (YscW)
YP_0792	COG3695	enzyme binding
YP_0796	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YP_0798	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YP_0799	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YP_0800	COG1309	transcriptional regulator
YP_0801	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
YP_0802	COG1196	nuclear chromosome segregation
YP_0802	COG3264	Mechanosensitive ion channel
YP_0805	COG2832	Protein of unknown function (DUF454)
YP_0807	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
YP_0814	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YP_0814	COG0543	2 iron, 2 sulfur cluster binding
YP_0818	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YP_0826	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YP_0830	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YP_0831	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YP_0832	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YP_0832	COG4651	solute:proton antiporter activity
YP_0833	COG2223	nitrite transmembrane transporter activity
YP_0836	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YP_0837	COG3735	TraB family
YP_0838	COG2217	Heavy metal translocating P-type atpase
YP_0839	COG0789	Transcriptional regulator
YP_0840	COG1585	Membrane protein implicated in regulation of membrane protease activity
YP_0841	COG0330	HflC and HflK could
YP_0842	COG3118	belongs to the thioredoxin family
YP_0843	COG0300	oxidoreductase activity
YP_0844	COG2755	lipolytic protein G-D-S-L family
YP_0845	COG4181	ATPase activity
YP_0846	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
YP_0847	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
YP_0848	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
YP_0851	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YP_0853	COG1943	Transposase
YP_0854	COG2501	S4 domain
YP_0861	COG0582	viral genome integration into host DNA
YP_0864	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
YP_0865	COG4589	Belongs to the CDS family
YP_0867	COG2267	carboxylic ester hydrolase activity
YP_0868	COG0671	phosphoesterase, PA-phosphatase related
YP_0868	COG2453	phosphatase
YP_0876	COG1067	ATP-dependent peptidase activity
YP_0878	COG1943	Transposase
YP_0880	COG3082	Protein of unknown function (DUF1414)
YP_0881	COG3083	sulfuric ester hydrolase activity
YP_0883	COG3157	Type VI secretion system effector, Hcp
YP_0886	COG2723	6-phospho-beta-galactosidase activity
YP_0887	COG1737	Transcriptional regulator
YP_0891	COG3299	homolog of phage Mu protein gp47
YP_0899	COG4386	tail sheath protein
YP_0903	COG3622	Belongs to the hyi family
YP_0904	COG1349	DNA-binding transcription factor activity
YP_0905	COG0235	Class ii aldolase
YP_0906	COG3395	kinase activity
YP_0915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
YP_0916	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
YP_0917	COG2223	nitrite transmembrane transporter activity
YP_0920	COG2205	protein histidine kinase activity
YP_0920	COG0784	Response regulator, receiver
YP_0925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YP_0929	COG0814	amino acid
YP_0934	COG0697	spore germination
YP_0936	COG1982	Orn Lys Arg decarboxylase major
YP_0937	COG0531	amino acid
YP_0938	COG1174	glycine betaine transport
YP_0939	COG1125	glycine betaine transport
YP_0940	COG1174	glycine betaine transport
YP_0942	COG2897	thiosulfate sulfurtransferase activity
YP_0945	COG0410	ABC transporter
YP_0946	COG1122	ATPase activity
YP_0950	COG4807	Protein conserved in bacteria
YP_0953	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
YP_0955	COG2261	transglycosylase associated protein
YP_0958	COG1403	HNH endonuclease
YP_0960	COG0277	FAD linked oxidase domain protein
YP_0961	COG1686	Belongs to the peptidase S11 family
YP_0963	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YP_0965	COG1943	Transposase
YP_0968	COG3328	transposase activity
YP_0973	COG0513	Belongs to the DEAD box helicase family
YP_0974	COG1309	transcriptional regulator
YP_0976	COG1131	(ABC) transporter
YP_0977	COG0842	Transport permease protein
YP_0978	COG0842	Transport permease protein
YP_0982	COG1902	pentaerythritol trinitrate reductase activity
YP_0987	COG1943	Transposase
YP_0988	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
YP_0990	COG0583	DNA-binding transcription factor activity
YP_0991	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YP_0995	COG1943	Transposase
YP_0996	COG0670	Belongs to the BI1 family
YP_0997	COG0314	molybdopterin synthase activity
YP_0998	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
YP_1000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YP_1001	COG0391	Required for morphogenesis under gluconeogenic growth conditions
YP_1002	COG4628	conserved protein (DUF2132)
YP_1003	COG0556	nucleotide-excision repair
YP_1006	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YP_1007	COG2226	methyltransferase
YP_1012	COG0561	phosphatase activity
YP_1014	COG4149	molybdate abc transporter
YP_1015	COG0725	ABC transporter, periplasmic molybdate-binding protein
YP_1017	COG3585	molybdate ion transport
YP_1017	COG2005	Transcriptional regulator
YP_1018	COG1119	ATPase activity
YP_1020	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YP_1021	COG1085	galactose-1-phosphate uridylyltransferase
YP_1026	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YP_1027	COG1230	cation diffusion facilitator family transporter
YP_1030	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
YP_1031	COG2885	chlorophyll binding
YP_1033	COG3064	Membrane
YP_1033	COG3064	Membrane
YP_1034	COG0848	biopolymer transport protein
YP_1035	COG0811	peptide transport
YP_1036	COG0824	Thioesterase
YP_1037	COG3790	cyd operon protein YbgE
YP_1038	COG1294	oxidase, subunit
YP_1039	COG1271	oxidase subunit
YP_1040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
YP_1042	COG0508	dehydrogenase complex catalyzes the overall conversion of
YP_1043	COG0567	Dehydrogenase, E1 component
YP_1045	COG1053	succinate dehydrogenase
YP_1046	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
YP_1047	COG2009	succinate dehydrogenase
YP_1050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YP_1051	COG0497	DNA recombination
YP_1052	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YP_1054	COG2867	negative regulation of translational initiation
YP_1056	COG1943	Transposase
YP_1057	COG0582	viral genome integration into host DNA
YP_1070	COG3657	addiction module killer protein
YP_1074	COG2963	transposase activity
YP_1077	COG0596	Alpha beta hydrolase
YP_1081	COG0735	belongs to the Fur family
YP_1085	COG2190	(PTS) system
YP_1085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YP_1085	COG1263	PTS System
YP_1087	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
YP_1088	COG1940	carbohydrate kinase activity
YP_1088	COG1846	Transcriptional regulator
YP_1090	COG0367	asparagine synthase
YP_1092	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YP_1094	COG1702	phosphate starvation-inducible protein PhoH
YP_1096	COG4535	Mg2 and Co2 transporter CorC
YP_1097	COG0815	Transfers the fatty acyl group on membrane lipoproteins
YP_1099	COG0765	amino acid transport
YP_1100	COG0765	amino acid transport
YP_1101	COG1126	abc transporter atp-binding protein
YP_1102	COG2888	peptidyl-tyrosine sulfation
YP_1105	COG1466	dna polymerase III delta subunit
YP_1107	COG0799	negative regulation of ribosome biogenesis
YP_1109	COG0768	penicillin binding
YP_1110	COG0772	Belongs to the SEDS family
YP_1111	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YP_1112	COG1686	Belongs to the peptidase S11 family
YP_1117	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YP_1118	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YP_1120	COG1278	Cold shock
YP_1121	COG1278	Cold shock
YP_1122	COG2197	response regulator
YP_1127	COG5265	(ABC) transporter
YP_1128	COG3718	enzyme involved in inositol metabolism
YP_1130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YP_1131	COG0673	inositol 2-dehydrogenase activity
YP_1132	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_1133	COG1129	ABC transporter
YP_1134	COG1879	ABC-type sugar transport system periplasmic component
YP_1136	COG3962	Belongs to the TPP enzyme family
YP_1141	COG2373	Large extracellular alpha-helical protein
YP_1142	COG4953	penicillin-binding protein 1C
YP_1143	COG3423	Transcriptional regulator
YP_1156	COG3328	transposase activity
YP_1162	COG0656	L-ascorbic acid biosynthetic process
YP_1163	COG0667	Aldo Keto reductase
YP_1168	COG1943	Transposase
YP_1171	COG3009	Protein conserved in bacteria
YP_1172	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YP_1172	COG3008	intermembrane lipid transfer
YP_1173	COG2995	paraquat-inducible protein a
YP_1174	COG0488	(ABC) transporter
YP_1176	COG3217	Mosc domain protein beta barrel domain protein
YP_1176	COG0633	Ferredoxin
YP_1179	COG0308	aminopeptidase N
YP_1183	COG1448	Aminotransferase
YP_1184	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YP_1185	COG3108	Peptidase M15
YP_1186	COG2989	Protein conserved in bacteria
YP_1187	COG1943	Transposase
YP_1189	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
YP_1190	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
YP_1191	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YP_1192	COG3173	Aminoglycoside phosphotransferase
YP_1194	COG2835	tetraacyldisaccharide 4'-kinase activity
YP_1195	COG1278	Cold shock
YP_1196	COG5383	Protein conserved in bacteria
YP_1199	COG2333	competence protein COMEC
YP_1199	COG0658	competence protein
YP_1201	COG0539	negative regulation of cytoplasmic translation
YP_1206	COG5295	Hep Hag repeat protein
YP_1206	COG5295	Hep Hag repeat protein
YP_1207	COG0252	asparaginase activity
YP_1208	COG1944	ATP diphosphatase activity
YP_1209	COG2116	formate transmembrane transporter activity
YP_1210	COG1882	Formate acetyltransferase
YP_1212	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
YP_1213	COG2814	Major facilitator Superfamily
YP_1215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YP_1217	COG3107	peptidoglycan biosynthetic process
YP_1217	COG1674	ftsk spoiiie
YP_1219	COG0492	ferredoxin-NADP+ reductase activity
YP_1221	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
YP_1223	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
YP_1224	COG1943	Transposase
YP_1225	COG0542	response to heat
YP_1228	COG1278	Cold shock
YP_1230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YP_1232	COG2990	Protein conserved in bacteria
YP_1233	COG3593	DNA synthesis involved in DNA repair
YP_1234	COG2431	L-lysine efflux transmembrane transporter activity
YP_1236	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YP_1237	COG0028	Belongs to the TPP enzyme family
YP_1239	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
YP_1240	COG0702	epimerase
YP_1241	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YP_1243	COG1605	Chorismate mutase
YP_1244	COG1126	abc transporter atp-binding protein
YP_1245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YP_1246	COG4215	(ABC) transporter
YP_1247	COG4160	amino acid transport
YP_1251	COG1120	ATPase activity
YP_1252	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YP_1256	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YP_1259	COG1177	transmembrane transport
YP_1260	COG1176	ABC-type spermidine putrescine transport system, permease component I
YP_1261	COG3842	ATPase activity
YP_1262	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
YP_1265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YP_1266	COG2985	domain, Protein
YP_1266	COG0569	domain protein
YP_1268	COG0671	phosphoesterase, PA-phosphatase related
YP_1269	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YP_1270	COG1349	DNA-binding transcription factor activity
YP_1271	COG0814	amino acid
YP_1272	COG1686	Belongs to the peptidase S11 family
YP_1273	COG2011	ABC-type metal ion transport system permease component
YP_1278	COG0625	glutathione transferase activity
YP_1279	COG4771	TonB-dependent receptor
YP_1281	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YP_1283	COG0833	amino acid
YP_1284	COG0583	DNA-binding transcription factor activity
YP_1285	COG2855	membrane
YP_1287	COG3188	usher protein
YP_1288	COG3121	Chaperone
YP_1291	COG3710	Transcriptional regulator
YP_1292	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YP_1292	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
YP_1292	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YP_1293	COG1105	Belongs to the carbohydrate kinase PfkB family
YP_1295	COG0494	nUDIX hydrolase
YP_1296	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_1297	COG1129	ABC transporter
YP_1299	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YP_1304	COG1028	Short-chain dehydrogenase reductase Sdr
YP_1308	COG1312	Catalyzes the dehydration of D-mannonate
YP_1309	COG0246	Mannitol dehydrogenase
YP_1310	COG2186	Transcriptional regulator
YP_1312	COG0523	cobalamin synthesis protein
YP_1313	COG0671	phosphoesterase, PA-phosphatase related
YP_1314	COG0791	NLP P60 protein
YP_1315	COG2200	EAL domain
YP_1316	COG4166	transmembrane transport
YP_1317	COG4174	ABC transporter (Permease)
YP_1318	COG4239	(ABC) transporter, permease
YP_1319	COG4172	Belongs to the ABC transporter superfamily
YP_1321	COG2814	Major facilitator Superfamily
YP_1322	COG1187	pseudouridine synthase activity
YP_1323	COG1061	Type III restriction enzyme res subunit
YP_1325	COG1943	Transposase
YP_1326	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
YP_1326	COG2885	chlorophyll binding
YP_1328	COG3070	regulator of competence-specific genes
YP_1329	COG1289	transmembrane transporter activity
YP_1330	COG3304	Inner membrane component domain
YP_1331	COG0210	DNA helicase
YP_1333	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
YP_1334	COG1832	CoA-binding protein
YP_1338	COG2920	part of a sulfur-relay system
YP_1344	COG1028	Short-chain dehydrogenase reductase Sdr
YP_1346	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YP_1347	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YP_1348	COG1028	Short-chain dehydrogenase reductase Sdr
YP_1349	COG3425	synthase
YP_1351	COG1024	Enoyl-CoA hydratase
YP_1352	COG1028	Short-chain dehydrogenase reductase Sdr
YP_1354	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YP_1355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YP_1381	COG0488	(ABC) transporter
YP_1383	COG3328	transposase activity
YP_1385	COG0303	'Molybdopterin
YP_1387	COG1136	(ABC) transporter
YP_1393	COG0583	DNA-binding transcription factor activity
YP_1394	COG0477	Major facilitator Superfamily
YP_1396	COG2311	Membrane
YP_1399	COG4211	Belongs to the binding-protein-dependent transport system permease family
YP_1400	COG2949	membrane
YP_1403	COG1346	cytolysis
YP_1405	COG2814	Major facilitator Superfamily
YP_1410	COG1943	Transposase
YP_1412	COG0489	protein tyrosine kinase activity
YP_1415	COG2982	Protein involved in outer membrane biogenesis
YP_1416	COG1253	flavin adenine dinucleotide binding
YP_1417	COG4114	ferric iron reductase
YP_1418	COG0076	glutamate decarboxylase activity
YP_1419	COG3486	L-lysine 6-monooxygenase (NADPH) activity
YP_1422	COG1120	ATPase activity
YP_1423	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YP_1424	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YP_1425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YP_1428	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YP_1429	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YP_1431	COG0140	phosphoribosyl-ATP diphosphatase activity
YP_1431	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YP_1434	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
YP_1435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YP_1435	COG0131	Imidazoleglycerol-phosphate dehydratase
YP_1437	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
YP_1440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YP_1442	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_1444	COG0371	Dehydrogenase
YP_1445	COG0531	amino acid
YP_1446	COG2925	Exonuclease
YP_1451	COG2271	Major facilitator Superfamily
YP_1452	COG3011	Protein conserved in bacteria
YP_1453	COG1028	Short-chain dehydrogenase reductase Sdr
YP_1455	COG4948	Mandelate Racemase Muconate Lactonizing
YP_1459	COG0534	Mate efflux family protein
YP_1463	COG3122	Protein conserved in bacteria
YP_1467	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YP_1470	COG2223	nitrite transmembrane transporter activity
YP_1475	COG1132	(ABC) transporter
YP_1478	COG2207	Transcriptional regulator
YP_1484	COG1113	amino acid transport
YP_1486	COG1278	Cold shock
YP_1488	COG2226	methyltransferase
YP_1490	COG5002	protein histidine kinase activity
YP_1490	COG3447	MASE1 domain protein
YP_1490	COG5001	Diguanylate cyclase
YP_1498	COG0395	ABC-type sugar transport system, permease component
YP_1499	COG1175	transmembrane transport
YP_1501	COG0673	inositol 2-dehydrogenase activity
YP_1528	COG2197	response regulator
YP_1530	COG3136	membrane protein required for alginate biosynthesis
YP_1534	COG1113	amino acid transport
YP_1537	COG2837	iron assimilation
YP_1542	COG0506	proline dehydrogenase activity
YP_1542	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YP_1542	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YP_1548	COG2515	1-aminocyclopropane-1-carboxylate deaminase
YP_1550	COG1191	sigma factor activity
YP_1558	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
YP_1561	COG1677	Flagellar hook-basal body complex protein FliE
YP_1563	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
YP_1565	COG1157	protein secretion by the type III secretion system
YP_1566	COG2882	bacterial-type flagellum organization
YP_1568	COG1580	Controls the rotational direction of flagella during chemotaxis
YP_1573	COG1987	bacterial-type flagellum assembly
YP_1577	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YP_1578	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_1579	COG1129	ABC transporter
YP_1581	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_1582	COG3347	Dehydrogenase
YP_1582	COG1028	Short-chain dehydrogenase reductase Sdr
YP_1583	COG2390	Transcriptional regulator
YP_1585	COG1256	bacterial-type flagellum assembly
YP_1589	COG4786	Flagellar basal body rod
YP_1591	COG1749	Flagellar hook protein flgE
YP_1592	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
YP_1593	COG1558	bacterial-type flagellum-dependent cell motility
YP_1594	COG1815	bacterial-type flagellum-dependent cell motility
YP_1596	COG2747	anti-sigma28 factor FlgM
YP_1597	COG3418	PFAM FlgN family protein
YP_1599	COG1943	Transposase
YP_1601	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YP_1602	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YP_1608	COG2372	response to copper ion
YP_1610	COG1528	Iron-storage protein
YP_1613	COG1770	oligopeptidase
YP_1616	COG3141	response to X-ray
YP_1617	COG0513	Belongs to the DEAD box helicase family
YP_1622	COG1760	l-serine dehydratase
YP_1623	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YP_1624	COG2368	4-hydroxyphenylacetate
YP_1627	COG3971	2-oxopent-4-enoate hydratase activity
YP_1629	COG3384	dioxygenase
YP_1630	COG1012	belongs to the aldehyde dehydrogenase family
YP_1632	COG1846	Transcriptional regulator
YP_1633	COG1253	flavin adenine dinucleotide binding
YP_1634	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YP_1634	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YP_1635	COG3715	PTS system
YP_1636	COG3716	PTS system mannose fructose sorbose family IID component
YP_1649	COG4771	TonB-dependent receptor
YP_1650	COG1021	2,3-dihydroxybenzoate-AMP ligase
YP_1654	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YP_1654	COG3433	isochorismatase activity
YP_1654	COG2226	methyltransferase
YP_1657	COG1132	(ABC) transporter
YP_1658	COG2814	Major facilitator Superfamily
YP_1659	COG1169	isochorismate synthase
YP_1660	COG0582	viral genome integration into host DNA
YP_1661	COG3121	Chaperone
YP_1663	COG3188	usher protein
YP_1666	COG2205	protein histidine kinase activity
YP_1666	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YP_1668	COG0427	acetyl-CoA hydrolase
YP_1669	COG2030	dehydratase
YP_1677	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YP_1678	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YP_1680	COG1349	DNA-binding transcription factor activity
YP_1682	COG2066	Belongs to the glutaminase family
YP_1685	COG0672	)-iron permease
YP_1688	COG0577	efflux transmembrane transporter activity
YP_1688	COG1136	(ABC) transporter
YP_1690	COG0577	efflux transmembrane transporter activity
YP_1690	COG1136	(ABC) transporter
YP_1694	COG0006	proline dipeptidase activity
YP_1695	COG0457	Tetratricopeptide repeat
YP_1696	COG1649	PFAM Uncharacterised BCR, COG1649
YP_1696	COG0726	polysaccharide deacetylase
YP_1697	COG1215	transferase activity, transferring glycosyl groups
YP_1698	COG3658	cytochrome
YP_1701	COG3328	transposase activity
YP_1702	COG1702	phosphate starvation-inducible protein PhoH
YP_1703	COG0387	Pfam Sodium calcium exchanger
YP_1704	COG3850	Histidine kinase
YP_1705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YP_1722	COG3121	Chaperone
YP_1726	COG3008	intermembrane lipid transfer
YP_1727	COG2995	paraquat-inducible protein a
YP_1728	COG1956	GAF domain-containing protein
YP_1730	COG0793	Belongs to the peptidase S41A family
YP_1732	COG3539	Fimbrial protein
YP_1733	COG3121	Chaperone
YP_1736	COG3121	Chaperone
YP_1737	COG2814	Major facilitator Superfamily
YP_1738	COG0823	Involved in the tonB-independent uptake of proteins
YP_1740	COG3023	N-Acetylmuramoyl-L-alanine amidase
YP_1742	COG1988	membrane-bound metal-dependent
YP_1743	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YP_1744	COG1653	transport
YP_1745	COG3842	ATPase activity
YP_1746	COG0395	ABC-type sugar transport system, permease component
YP_1747	COG1175	transmembrane transport
YP_1749	COG1028	Short-chain dehydrogenase reductase Sdr
YP_1752	COG3328	transposase activity
YP_1753	COG3134	Outer membrane lipoprotein
YP_1754	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
YP_1755	COG4591	ABC-type transport system involved in lipoprotein release permease component
YP_1757	COG4591	ABC-type transport system involved in lipoprotein release permease component
YP_1760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
YP_1762	COG2850	peptidyl-arginine hydroxylation
YP_1764	COG0745	RESPONSE REGULATOR receiver
YP_1766	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YP_1770	COG1187	pseudouridine synthase activity
YP_1771	COG0538	isocitrate dehydrogenase activity
YP_1774	COG0840	transmembrane signaling receptor activity
YP_1775	COG0702	epimerase
YP_1776	COG1733	regulation of RNA biosynthetic process
YP_1781	COG1522	sequence-specific DNA binding
YP_1784	COG3321	synthase
YP_1784	COG1028	Short-chain dehydrogenase reductase Sdr
YP_1784	COG0604	alcohol dehydrogenase
YP_1786	COG1278	Cold shock
YP_1790	COG1285	pathogenesis
YP_1795	COG1360	Flagellar Motor Protein
YP_1796	COG0643	Histidine kinase
YP_1796	COG2198	Histidine kinase
YP_1797	COG0835	chemotaxis
YP_1798	COG2271	Major facilitator Superfamily
YP_1799	COG0251	oxidation-reduction process
YP_1801	COG2964	Protein conserved in bacteria
YP_1802	COG3328	transposase activity
YP_1806	COG0840	transmembrane signaling receptor activity
YP_1807	COG0840	transmembrane signaling receptor activity
YP_1808	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YP_1810	COG0745	RESPONSE REGULATOR receiver
YP_1811	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
YP_1812	COG3023	N-Acetylmuramoyl-L-alanine amidase
YP_1815	COG3328	transposase activity
YP_1824	COG0402	S-adenosylhomocysteine deaminase activity
YP_1828	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YP_1835	COG3328	transposase activity
YP_1839	COG0500	methyltransferase
YP_1847	COG5002	protein histidine kinase activity
YP_1858	COG0012	GTP binding
YP_1861	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YP_1866	COG2890	protein-(glutamine-N5) methyltransferase activity
YP_1867	COG3094	Invasion gene expression up-regulator, SirB
YP_1868	COG2912	Transglutaminase-like superfamily
YP_1870	COG0659	secondary active sulfate transmembrane transporter activity
YP_1874	COG3833	ABC-type maltose transport systems, permease component
YP_1875	COG1176	ABC-type spermidine putrescine transport system, permease component I
YP_1877	COG1943	Transposase
YP_1878	COG0584	glycerophosphoryl diester phosphodiesterase
YP_1879	COG1940	carbohydrate kinase activity
YP_1881	COG3381	protein complex oligomerization
YP_1884	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YP_1886	COG0728	peptidoglycan biosynthetic process
YP_1890	COG3102	Protein conserved in bacteria
YP_1894	COG3788	relative of glutathione S-transferase, MAPEG superfamily
YP_1895	COG1801	Protein of unknown function DUF72
YP_1897	COG0494	nUDIX hydrolase
YP_1902	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YP_1904	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
YP_1905	COG0739	heme binding
YP_1906	COG1560	Kdo2-lipid A biosynthetic process
YP_1907	COG0469	pyruvate kinase activity
YP_1908	COG1737	Transcriptional regulator
YP_1909	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YP_1910	COG0800	Aldolase
YP_1913	COG0251	oxidation-reduction process
YP_1914	COG1199	ATP-dependent helicase activity
YP_1916	COG3065	identical protein binding
YP_1917	COG0318	PFAM AMP-dependent synthetase and ligase
YP_1918	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
YP_1919	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
YP_1920	COG2894	cell division
YP_1924	COG2951	lytic endotransglycosylase activity
YP_1925	COG0179	Fumarylacetoacetate (FAA) hydrolase
YP_1939	COG3328	transposase activity
YP_1941	COG1104	cysteine desulfurase activity
YP_1947	COG2719	SpoVR family
YP_1949	COG2814	Major facilitator Superfamily
YP_1951	COG0583	DNA-binding transcription factor activity
YP_1954	COG2766	serine protein kinase
YP_1955	COG3713	MltA-interacting MipA family protein
YP_1959	COG3139	Protein of unknown function (DUF1315)
YP_1960	COG1335	isochorismatase
YP_1961	COG0252	asparaginase activity
YP_1962	COG0616	signal peptide processing
YP_1963	COG0778	Nitroreductase
YP_1964	COG0709	Synthesizes selenophosphate from selenide and ATP
YP_1965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YP_1967	COG0494	nUDIX hydrolase
YP_1968	COG0708	Exodeoxyribonuclease III
YP_1969	COG0583	DNA-binding transcription factor activity
YP_1970	COG0788	formyltetrahydrofolate deformylase activity
YP_1972	COG0745	RESPONSE REGULATOR receiver
YP_1975	COG1435	thymidine kinase activity
YP_1976	COG1012	belongs to the aldehyde dehydrogenase family
YP_1976	COG1454	alcohol dehydrogenase
YP_1978	COG2095	MarC family integral membrane protein
YP_1980	COG0601	transmembrane transport
YP_1981	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YP_1982	COG0444	Belongs to the ABC transporter superfamily
YP_1983	COG4608	Belongs to the ABC transporter superfamily
YP_1991	COG2350	Protein conserved in bacteria
YP_1992	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
YP_1993	COG3328	transposase activity
YP_1994	COG1607	acyl-coa hydrolase
YP_1999	COG3047	cAMP biosynthetic process
YP_2003	COG0135	phosphoribosylanthranilate isomerase activity
YP_2003	COG0134	indole-3-glycerol-phosphate synthase activity
YP_2005	COG0512	Glutamine amidotransferase of anthranilate synthase
YP_2009	COG0009	L-threonylcarbamoyladenylate synthase
YP_2010	COG1187	pseudouridine synthase activity
YP_2012	COG1028	Short-chain dehydrogenase reductase Sdr
YP_2013	COG0616	signal peptide processing
YP_2016	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YP_2017	COG0583	DNA-binding transcription factor activity
YP_2019	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
YP_2020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YP_2022	COG0671	phosphoesterase, PA-phosphatase related
YP_2023	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
YP_2024	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
YP_2027	COG0023	Translation Initiation Factor
YP_2031	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YP_2032	COG2879	small protein
YP_2033	COG1966	Carbon starvation protein
YP_2035	COG2271	Major facilitator Superfamily
YP_2036	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YP_2037	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YP_2039	COG4659	FMN binding
YP_2040	COG4658	electron transport chain
YP_2041	COG3708	Transcriptional regulator
YP_2041	COG2207	Transcriptional regulator
YP_2048	COG2274	protein secretion by the type I secretion system
YP_2051	COG1879	ABC-type sugar transport system periplasmic component
YP_2053	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_2055	COG0673	inositol 2-dehydrogenase activity
YP_2056	COG0385	Bile acid
YP_2059	COG5339	Protein conserved in bacteria
YP_2061	COG0114	fumarate hydratase activity
YP_2064	COG1940	carbohydrate kinase activity
YP_2065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YP_2066	COG0038	chloride channel
YP_2067	COG1609	Transcriptional regulator
YP_2071	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YP_2072	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YP_2074	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YP_2079	COG0028	Belongs to the TPP enzyme family
YP_2080	COG0440	acetolactate synthase activity
YP_2081	COG1011	Hydrolase
YP_2084	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YP_2085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YP_2086	COG0589	response to stress
YP_2087	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
YP_2088	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
YP_2091	COG0531	amino acid
YP_2093	COG0745	RESPONSE REGULATOR receiver
YP_2097	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
YP_2098	COG1943	Transposase
YP_2103	COG3038	cytochrome b561
YP_2106	COG3591	Belongs to the peptidase S1B family
YP_2109	COG1643	Atp-dependent helicase
YP_2111	COG2390	Transcriptional regulator
YP_2112	COG0246	Mannitol dehydrogenase
YP_2113	COG3784	Protein of unknown function (DUF1318)
YP_2114	COG2911	Protein conserved in bacteria
YP_2115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YP_2116	COG3187	Heat shock protein
YP_2117	COG3042	response to heat
YP_2118	COG1285	pathogenesis
YP_2120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YP_2120	COG0674	pyruvate-flavodoxin oxidoreductase activity
YP_2120	COG1013	pyruvate-flavodoxin oxidoreductase activity
YP_2120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YP_2122	COG2755	lipolytic protein G-D-S-L family
YP_2122	COG0657	acetylesterase activity
YP_2126	COG4166	transmembrane transport
YP_2127	COG2866	Carboxypeptidase
YP_2128	COG4948	Mandelate Racemase Muconate Lactonizing
YP_2129	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
YP_2130	COG1943	Transposase
YP_2135	COG3106	COG3106 Predicted ATPase
YP_2137	COG1983	PspC domain protein
YP_2139	COG1842	Phage shock protein A
YP_2140	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
YP_2141	COG1943	Transposase
YP_2144	COG4166	transmembrane transport
YP_2145	COG4168	peptide transport system, permease
YP_2146	COG4171	peptide transport system, permease
YP_2148	COG4172	Belongs to the ABC transporter superfamily
YP_2149	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YP_2149	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YP_2150	COG3104	oligopeptide transport
YP_2153	COG0625	glutathione transferase activity
YP_2157	COG3895	Periplasmic Protein
YP_2159	COG3133	Outer membrane lipoprotein
YP_2161	COG4989	oxidoreductase activity
YP_2162	COG3313	Fe-S protein
YP_2163	COG2194	sulfuric ester hydrolase activity
YP_2164	COG1309	transcriptional regulator
YP_2165	COG1902	pentaerythritol trinitrate reductase activity
YP_2167	COG0346	lactoylglutathione lyase activity
YP_2168	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YP_2169	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
YP_2171	COG0791	NLP P60 protein
YP_2172	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YP_2174	COG0583	DNA-binding transcription factor activity
YP_2175	COG2814	Major facilitator Superfamily
YP_2176	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YP_2177	COG0307	riboflavin synthase, alpha
YP_2181	COG4238	major outer membrane lipoprotein
YP_2182	COG1943	Transposase
YP_2188	COG0719	Fe-S assembly protein
YP_2189	COG0396	ATPase activity
YP_2190	COG0719	Fe-S assembly protein
YP_2191	COG0316	Belongs to the HesB IscA family
YP_2193	COG2050	protein possibly involved in aromatic compounds catabolism
YP_2194	COG0277	FAD linked oxidase domain protein
YP_2194	COG0247	lactate metabolic process
YP_2195	COG0628	permease
YP_2196	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YP_2196	COG0574	Belongs to the PEP-utilizing enzyme family
YP_2201	COG0791	NLP P60 protein
YP_2210	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
YP_2211	COG0386	Belongs to the glutathione peroxidase family
YP_2214	COG0776	regulation of translation
YP_2215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YP_2215	COG0072	phenylalanine-tRNA ligase activity
YP_2216	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
YP_2222	COG4249	Peptidase C14 caspase catalytic subunit p20
YP_2227	COG0803	Belongs to the bacterial solute-binding protein 9 family
YP_2228	COG1121	(ABC) transporter
YP_2229	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YP_2230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YP_2233	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YP_2234	COG3328	transposase activity
YP_2237	COG1252	NADH dehydrogenase
YP_2239	COG1472	Belongs to the glycosyl hydrolase 3 family
YP_2242	COG5633	Lipoprotein
YP_2243	COG0537	adenosine 5'-monophosphoramidase activity
YP_2244	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YP_2245	COG1943	Transposase
YP_2246	COG1263	PTS System
YP_2246	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YP_2247	COG0084	hydrolase, TatD family'
YP_2248	COG0470	DNA polymerase III
YP_2250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YP_2251	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YP_2252	COG1943	Transposase
YP_2253	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YP_2255	COG1028	Short-chain dehydrogenase reductase Sdr
YP_2259	COG0333	Belongs to the bacterial ribosomal protein bL32 family
YP_2260	COG1399	metal-binding, possibly nucleic acid-binding protein
YP_2262	COG0564	pseudouridine synthase activity
YP_2263	COG1530	ribonuclease E activity
YP_2267	COG3328	transposase activity
YP_2270	COG0628	permease
YP_2275	COG3916	Acyl-homoserine-lactone synthase
YP_2276	COG2771	luxR family
YP_2277	COG0583	DNA-binding transcription factor activity
YP_2278	COG0477	Major facilitator Superfamily
YP_2280	COG0667	Aldo Keto reductase
YP_2286	COG1203	CRISPR-associated helicase, Cas3
YP_2287	COG1518	maintenance of DNA repeat elements
YP_2288	COG0668	transmembrane transport
YP_2293	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
YP_2294	COG0395	ABC-type sugar transport system, permease component
YP_2297	COG1609	Transcriptional regulator
YP_2299	COG3842	ATPase activity
YP_2301	COG3210	domain, Protein
YP_2305	COG3210	domain, Protein
YP_2306	COG2831	hemolysin activation secretion protein
YP_2307	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YP_2308	COG4638	Rieske (2fe-2S)
YP_2309	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YP_2311	COG0473	3-isopropylmalate dehydrogenase activity
YP_2312	COG0583	DNA-binding transcription factor activity
YP_2313	COG1609	Transcriptional regulator
YP_2314	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_2315	COG1129	ABC transporter
YP_2316	COG1879	ABC-type sugar transport system periplasmic component
YP_2317	COG1063	alcohol dehydrogenase
YP_2321	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
YP_2327	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YP_2328	COG0765	amino acid transport
YP_2329	COG1126	abc transporter atp-binding protein
YP_2333	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YP_2336	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
YP_2339	COG1169	isochorismate synthase
YP_2341	COG4575	ribosome binding
YP_2344	COG0129	dihydroxy-acid dehydratase activity
YP_2347	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YP_2348	COG1609	Transcriptional regulator
YP_2350	COG1028	Short-chain dehydrogenase reductase Sdr
YP_2351	COG3265	gluconokinase activity
YP_2352	COG2731	YhcH YjgK YiaL family protein
YP_2355	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YP_2356	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
YP_2358	COG0839	Belongs to the complex I subunit 6 family
YP_2361	COG1034	ATP synthesis coupled electron transport
YP_2363	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
YP_2365	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YP_2367	COG0583	DNA-binding transcription factor activity
YP_2369	COG0436	Aminotransferase
YP_2372	COG0471	metal ion transport
YP_2372	COG0490	domain, Protein
YP_2373	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YP_2378	COG0857	belongs to the CobB CobQ family
YP_2378	COG0280	phosphate acetyltransferase
YP_2379	COG1609	Transcriptional regulator
YP_2382	COG3037	sugar-specific permease SgaT UlaA
YP_2383	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
YP_2384	COG0622	Phosphoesterase
YP_2386	COG1090	epimerase
YP_2387	COG4598	ABC transporter
YP_2388	COG4160	amino acid transport
YP_2389	COG4215	(ABC) transporter
YP_2390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YP_2391	COG0163	prenyltransferase activity
YP_2392	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
YP_2393	COG1286	toxin biosynthetic process
YP_2394	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
YP_2395	COG0285	dihydrofolate synthase activity
YP_2397	COG0586	Pfam SNARE associated Golgi protein
YP_2399	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YP_2402	COG0697	spore germination
YP_2405	COG1794	racemase activity, acting on amino acids and derivatives
YP_2406	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YP_2409	COG3101	peptidyl-lysine hydroxylation
YP_2410	COG0730	response to heat
YP_2413	COG2890	protein-(glutamine-N5) methyltransferase activity
YP_2416	COG2062	phosphohistidine phosphatase, SixA
YP_2419	COG3691	Protein conserved in bacteria
YP_2422	COG3088	subunit of a heme lyase
YP_2422	COG4235	cytochrome complex assembly
YP_2423	COG4235	cytochrome complex assembly
YP_2423	COG3088	subunit of a heme lyase
YP_2424	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YP_2425	COG1138	Cytochrome C-type biogenesis protein
YP_2427	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YP_2428	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YP_2429	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YP_2432	COG1704	LemA family
YP_2434	COG2824	Alkylphosphonate utilization operon protein PhnA
YP_2436	COG3328	transposase activity
YP_2441	COG3501	Rhs element vgr protein
YP_2447	COG2113	Glycine betaine
YP_2448	COG4176	ABC-type proline glycine betaine transport system permease component
YP_2449	COG4175	Glycine betaine
YP_2450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YP_2457	COG3328	transposase activity
YP_2460	COG1278	Cold shock
YP_2461	COG0747	negative chemotaxis
YP_2463	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YP_2464	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YP_2465	COG1124	(ABC) transporter
YP_2471	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
YP_2473	COG4413	Urea transporter
YP_2474	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
YP_2476	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YP_2477	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YP_2478	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YP_2480	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YP_2481	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YP_2482	COG1447	Phosphotransferase system cellobiose-specific component IIA
YP_2483	COG2169	Transcriptional regulator
YP_2483	COG1917	Cupin 2, conserved barrel domain protein
YP_2487	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
YP_2488	COG0033	Phosphoglucomutase
YP_2491	COG0745	RESPONSE REGULATOR receiver
YP_2492	COG2205	protein histidine kinase activity
YP_2498	COG3272	Protein of unknown function (DUF1722)
YP_2500	COG5212	phosphodiesterase
YP_2501	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
YP_2503	COG1984	allophanate hydrolase subunit 2
YP_2512	COG0513	Belongs to the DEAD box helicase family
YP_2514	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
YP_2516	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
YP_2517	COG3026	antisigma factor binding
YP_2518	COG3086	response to oxidative stress
YP_2521	COG0681	Belongs to the peptidase S26 family
YP_2525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
YP_2527	COG1943	Transposase
YP_2528	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YP_2533	COG0560	Phosphoserine phosphatase
YP_2534	COG0590	tRNA wobble adenosine to inosine editing
YP_2540	COG1943	Transposase
YP_2541	COG2205	protein histidine kinase activity
YP_2542	COG3170	Tfp pilus assembly protein FimV
YP_2543	COG2204	response regulator
YP_2544	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YP_2544	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YP_2545	COG0347	Belongs to the P(II) protein family
YP_2547	COG1017	nitric oxide dioxygenase activity
YP_2547	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YP_2551	COG2814	Major facilitator Superfamily
YP_2552	COG3711	transcriptional antiterminator
YP_2553	COG3683	transport system, periplasmic component
YP_2554	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
YP_2555	COG0483	inositol monophosphate 1-phosphatase activity
YP_2558	COG1104	cysteine desulfurase activity
YP_2559	COG0822	iron-sulfur transferase activity
YP_2563	COG0443	Heat shock 70 kDa protein
YP_2564	COG0633	Ferredoxin
YP_2565	COG2975	iron-sulfur cluster assembly
YP_2569	COG3328	transposase activity
YP_2571	COG3121	Chaperone
YP_2583	COG2951	lytic endotransglycosylase activity
YP_2590	COG0243	molybdopterin cofactor binding
YP_2591	COG0437	4 iron, 4 sulfur cluster binding
YP_2592	COG3302	dmso reductase anchor subunit
YP_2593	COG3381	protein complex oligomerization
YP_2599	COG3038	cytochrome b561
YP_2600	COG0436	Aminotransferase
YP_2605	COG0667	Aldo Keto reductase
YP_2608	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YP_2613	COG3530	Putative quorum-sensing-regulated virulence factor
YP_2616	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
YP_2617	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YP_2618	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YP_2620	COG2190	(PTS) system
YP_2621	COG1943	Transposase
YP_2622	COG2205	protein histidine kinase activity
YP_2623	COG0745	RESPONSE REGULATOR receiver
YP_2624	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YP_2627	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YP_2630	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
YP_2632	COG3850	Histidine kinase
YP_2632	COG5002	protein histidine kinase activity
YP_2633	COG0745	RESPONSE REGULATOR receiver
YP_2636	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
YP_2637	COG4208	sulfate ABC transporter
YP_2638	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
YP_2639	COG4150	thiosulfate binding
YP_2641	COG1737	Transcriptional regulator
YP_2643	COG2731	YhcH YjgK YiaL family protein
YP_2645	COG4886	Leucine-rich repeat (LRR) protein
YP_2647	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YP_2648	COG2837	iron assimilation
YP_2650	COG3111	PFAM Bacterial OB fold (BOF) protein
YP_2659	COG3005	denitrification pathway
YP_2660	COG3043	anaerobic respiration
YP_2662	COG3062	negative regulation of establishment of protein localization
YP_2663	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YP_2663	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
YP_2664	COG2197	response regulator
YP_2666	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YP_2668	COG1988	membrane-bound metal-dependent
YP_2670	COG3842	ATPase activity
YP_2672	COG1840	ABC-type Fe3 transport system, periplasmic component
YP_2674	COG1393	Belongs to the ArsC family
YP_2676	COG1876	peptidase activity
YP_2680	COG2321	neutral zinc metallopeptidase
YP_2682	COG1943	Transposase
YP_2683	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
YP_2685	COG2716	regulation of RNA biosynthetic process
YP_2686	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YP_2690	COG0628	permease
YP_2691	COG4783	chaperone-mediated protein folding
YP_2692	COG1393	Belongs to the ArsC family
YP_2694	COG1943	Transposase
YP_2697	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
YP_2698	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YP_2701	COG0581	inorganic phosphate transmembrane transporter activity
YP_2703	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
YP_2704	COG0248	Ppx GppA phosphatase
YP_2706	COG2239	Acts as a magnesium transporter
YP_2707	COG0443	Heat shock 70 kDa protein
YP_2708	COG1177	transmembrane transport
YP_2709	COG1176	ABC-type spermidine putrescine transport system, permease component I
YP_2711	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YP_2713	COG3842	ATPase activity
YP_2718	COG2205	protein histidine kinase activity
YP_2719	COG0745	RESPONSE REGULATOR receiver
YP_2720	COG3422	double-strand break repair
YP_2725	COG0351	phosphomethylpyrimidine kinase
YP_2728	COG3328	transposase activity
YP_2735	COG1943	Transposase
YP_2737	COG0516	GMP reductase activity
YP_2737	COG0517	IMP dehydrogenase activity
YP_2739	COG1645	bacterial-type flagellum-dependent swarming motility
YP_2742	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YP_2743	COG2976	Protein conserved in bacteria
YP_2752	COG3468	outer membrane autotransporter barrel domain protein
YP_2754	COG3328	transposase activity
YP_2766	COG1953	Uracil, thiamine, allantoin
YP_2767	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YP_2769	COG2226	methyltransferase
YP_2771	COG1388	LysM domain
YP_2771	COG0741	lytic transglycosylase activity
YP_2774	COG0656	L-ascorbic acid biosynthetic process
YP_2775	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YP_2777	COG2011	ABC-type metal ion transport system permease component
YP_2778	COG1464	Belongs to the NlpA lipoprotein family
YP_2780	COG1720	tRNA m6t6A37 methyltransferase activity
YP_2782	COG3015	lipoprotein NlpE involved in copper resistance
YP_2784	COG4681	YaeQ
YP_2786	COG4568	rho-dependent transcription termination
YP_2788	COG0037	tRNA processing
YP_2789	COG0346	lactoylglutathione lyase activity
YP_2791	COG0587	DNA-directed DNA polymerase activity
YP_2793	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YP_2797	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
YP_2799	COG0750	zinc metalloprotease
YP_2800	COG0575	Belongs to the CDS family
YP_2801	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
YP_2808	COG0024	Methionine aminopeptidase
YP_2813	COG0564	pseudouridine synthase activity
YP_2814	COG3098	single-species biofilm formation
YP_2815	COG1943	Transposase
YP_2818	COG1611	Belongs to the LOG family
YP_2819	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YP_2821	COG2363	Small membrane protein
YP_2822	COG0583	DNA-binding transcription factor activity
YP_2823	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YP_2824	COG2166	iron-sulfur cluster assembly
YP_2825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
YP_2826	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
YP_2827	COG0860	N-Acetylmuramoyl-L-alanine amidase
YP_2837	COG0288	reversible hydration of carbon dioxide
YP_2845	COG2165	general secretion pathway protein
YP_2853	COG3328	transposase activity
YP_2855	COG0840	transmembrane signaling receptor activity
YP_2858	COG0583	DNA-binding transcription factor activity
YP_2859	COG2814	Major facilitator Superfamily
YP_2860	COG0583	DNA-binding transcription factor activity
YP_2861	COG0019	diaminopimelate decarboxylase activity
YP_2862	COG1609	Transcriptional regulator
YP_2868	COG0667	Aldo Keto reductase
YP_2881	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
YP_2883	COG1074	ATP-dependent DNA helicase activity
YP_2884	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
YP_2887	COG2259	Doxx family
YP_2889	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
YP_2890	COG4575	ribosome binding
YP_2894	COG0586	Pfam SNARE associated Golgi protein
YP_2897	COG2271	Major facilitator Superfamily
YP_2900	COG0246	Mannitol dehydrogenase
YP_2901	COG2721	sulfolactate sulfo-lyase activity
YP_2903	COG1943	Transposase
YP_2905	COG0673	inositol 2-dehydrogenase activity
YP_2906	COG1451	nucleotide metabolic process
YP_2909	COG0446	pyridine nucleotide-disulphide oxidoreductase
YP_2909	COG1902	pentaerythritol trinitrate reductase activity
YP_2910	COG3247	response to pH
YP_2917	COG4245	von Willebrand factor, type A
YP_2918	COG2831	hemolysin activation secretion protein
YP_2919	COG3210	domain, Protein
YP_2921	COG3210	domain, Protein
YP_2923	COG3210	domain, Protein
YP_2927	COG3842	ATPase activity
YP_2928	COG3459	Glycosyltransferase 36 associated
YP_2929	COG1609	Transcriptional regulator
YP_2930	COG1653	transport
YP_2932	COG0395	ABC-type sugar transport system, permease component
YP_2936	COG1289	transmembrane transporter activity
YP_2944	COG0251	oxidation-reduction process
YP_2956	COG3328	transposase activity
YP_2958	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YP_2959	COG0358	DNA primase activity
YP_2963	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
YP_2966	COG4991	sh3 domain protein
YP_2967	COG3025	triphosphatase activity
YP_2970	COG0531	amino acid
YP_2974	COG3384	dioxygenase
YP_2975	COG0754	glutathionylspermidine amidase activity
YP_2978	COG1538	Outer membrane efflux protein
YP_2979	COG0494	nUDIX hydrolase
YP_2980	COG3151	Protein conserved in bacteria
YP_2981	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YP_2982	COG3150	esterase
YP_2983	COG0187	DNA topoisomerase II activity
YP_2984	COG0583	DNA-binding transcription factor activity
YP_2985	COG2249	NAD(P)H dehydrogenase (quinone) activity
YP_2987	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YP_2988	COG0204	Acyl-transferase
YP_2989	COG2132	Multicopper oxidase
YP_2991	COG0656	L-ascorbic acid biosynthetic process
YP_2993	COG1979	alcohol dehydrogenase
YP_2994	COG2207	Transcriptional regulator
YP_2995	COG0586	Pfam SNARE associated Golgi protein
YP_2996	COG0626	cystathionine gamma-synthase activity
YP_2997	COG0811	peptide transport
YP_2998	COG0848	biopolymer transport protein
YP_3010	COG1943	Transposase
YP_3014	COG4592	Periplasmic binding protein
YP_3018	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YP_3019	COG1684	flagellar biosynthetic protein fliR
YP_3020	COG1987	bacterial-type flagellum assembly
YP_3024	COG2204	response regulator
YP_3033	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
YP_3034	COG1815	bacterial-type flagellum-dependent cell motility
YP_3035	COG1558	bacterial-type flagellum-dependent cell motility
YP_3036	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
YP_3037	COG1749	Flagellar hook protein flgE
YP_3038	COG4787	bacterial-type flagellum-dependent cell motility
YP_3039	COG4786	Flagellar basal body rod
YP_3040	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
YP_3041	COG1706	bacterial-type flagellum-dependent cell motility
YP_3043	COG1256	bacterial-type flagellum assembly
YP_3047	COG3710	Transcriptional regulator
YP_3049	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
YP_3054	COG1191	sigma factor activity
YP_3055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
YP_3064	COG2801	Transposase and inactivated derivatives
YP_3077	COG1175	transmembrane transport
YP_3078	COG3833	ABC-type maltose transport systems, permease component
YP_3081	COG0527	aspartate kinase activity
YP_3085	COG1414	Transcriptional regulator
YP_3087	COG2224	Isocitrate lyase
YP_3088	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
YP_3092	COG0151	Belongs to the GarS family
YP_3095	COG3068	Protein conserved in bacteria
YP_3096	COG1515	deoxyribonuclease V activity
YP_3102	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
YP_3104	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YP_3115	COG0250	Participates in transcription elongation, termination and antitermination
YP_3116	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
YP_3119	COG2801	Transposase and inactivated derivatives
YP_3123	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
YP_3126	COG1629	transport
YP_3131	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YP_3132	COG0678	peroxiredoxin activity
YP_3132	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YP_3140	COG1879	ABC-type sugar transport system periplasmic component
YP_3141	COG1129	ABC transporter
YP_3142	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_3143	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_3145	COG3085	chromosome segregation
YP_3148	COG3978	acetolactate synthase activity
YP_3149	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YP_3157	COG0583	DNA-binding transcription factor activity
YP_3165	COG3121	Chaperone
YP_3168	COG3121	Chaperone
YP_3172	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YP_3177	COG3118	belongs to the thioredoxin family
YP_3178	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
YP_3179	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_3180	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YP_3181	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
YP_3182	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
YP_3183	COG1088	dTDP-glucose 4,6-dehydratase activity
YP_3184	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
YP_3185	COG0456	acetyltransferase
YP_3186	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YP_3187	COG2244	polysaccharide biosynthetic process
YP_3191	COG1113	amino acid transport
YP_3193	COG1943	Transposase
YP_3194	COG3071	HemY protein
YP_3195	COG2959	enzyme of heme biosynthesis
YP_3196	COG1587	Uroporphyrinogen-III synthase
YP_3199	COG3072	Adenylate cyclase
YP_3201	COG5567	small periplasmic lipoprotein
YP_3203	COG3159	Protein conserved in bacteria
YP_3204	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
YP_3205	COG1011	Hydrolase
YP_3206	COG0210	DNA helicase
YP_3209	COG5441	Belongs to the UPF0261 family
YP_3210	COG5564	TIM-barrel signal transduction protein
YP_3211	COG0598	Magnesium transport protein CorA
YP_3213	COG2050	protein possibly involved in aromatic compounds catabolism
YP_3214	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
YP_3215	COG0514	ATP-dependent DNA helicase (RecQ)
YP_3216	COG1280	lysine exporter protein (LysE YggA)
YP_3217	COG1280	lysine exporter protein (LysE YggA)
YP_3218	COG2267	carboxylic ester hydrolase activity
YP_3219	COG0561	phosphatase activity
YP_3221	COG0584	glycerophosphoryl diester phosphodiesterase
YP_3222	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YP_3224	COG0247	lactate metabolic process
YP_3226	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
YP_3229	COG3714	YhhN family
YP_3232	COG3776	membrane
YP_3233	COG0742	ribosomal rna small subunit methyltransferase
YP_3235	COG0552	protein localization to endoplasmic reticulum
YP_3235	COG0552	protein localization to endoplasmic reticulum
YP_3236	COG2884	Cell division ATP-binding protein ftsE
YP_3237	COG2177	Part of the ABC transporter FtsEX involved in
YP_3239	COG1943	Transposase
YP_3241	COG0683	leucine binding
YP_3242	COG0559	Belongs to the binding-protein-dependent transport system permease family
YP_3243	COG4177	L-phenylalanine transmembrane transporter activity
YP_3244	COG0411	ABC transporter
YP_3245	COG0410	ABC transporter
YP_3257	COG0584	glycerophosphoryl diester phosphodiesterase
YP_3258	COG0679	Auxin Efflux Carrier
YP_3260	COG0583	DNA-binding transcription factor activity
YP_3262	COG0412	Dienelactone hydrolase
YP_3263	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
YP_3265	COG1966	Carbon starvation protein
YP_3266	COG0586	Pfam SNARE associated Golgi protein
YP_3267	COG1322	Protein conserved in bacteria
YP_3271	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YP_3273	COG0805	protein transport
YP_3284	COG1739	Uncharacterized protein family UPF0029
YP_3285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YP_3286	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
YP_3288	COG0812	UDP-N-acetylmuramate dehydrogenase activity
YP_3299	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YP_3300	COG0058	SHG alpha-glucan phosphorylase activity
YP_3302	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
YP_3305	COG3275	phosphorelay sensor kinase activity
YP_3311	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YP_3312	COG2095	MarC family integral membrane protein
YP_3315	COG3265	gluconokinase activity
YP_3316	COG2610	gluconate transmembrane transporter activity
YP_3317	COG1609	Transcriptional regulator
YP_3318	COG1741	Belongs to the pirin family
YP_3323	COG0191	fructose-bisphosphate aldolase activity
YP_3325	COG1879	ABC-type sugar transport system periplasmic component
YP_3326	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_3329	COG2081	HI0933 family
YP_3330	COG0306	phosphate transporter
YP_3331	COG1943	Transposase
YP_3333	COG0589	response to stress
YP_3337	COG0339	signal peptide processing
YP_3339	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
YP_3340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YP_3341	COG3835	regulator
YP_3342	COG2610	gluconate transmembrane transporter activity
YP_3343	COG1929	Belongs to the glycerate kinase type-1 family
YP_3348	COG1295	ribonuclease BN
YP_3349	COG2134	cdp-diacylglycerol pyrophosphatase
YP_3350	COG2982	Protein involved in outer membrane biogenesis
YP_3351	COG2200	EAL domain
YP_3352	COG1942	4-Oxalocrotonate Tautomerase
YP_3353	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YP_3354	COG0612	Peptidase, M16
YP_3358	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YP_3359	COG2199	diguanylate cyclase activity
YP_3359	COG2200	EAL domain
YP_3361	COG4608	Belongs to the ABC transporter superfamily
YP_3362	COG0444	Belongs to the ABC transporter superfamily
YP_3363	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YP_3364	COG0601	transmembrane transport
YP_3365	COG0747	negative chemotaxis
YP_3367	COG2831	hemolysin activation secretion protein
YP_3369	COG2271	Major facilitator Superfamily
YP_3370	COG3851	Histidine kinase
YP_3371	COG2197	response regulator
YP_3372	COG2194	sulfuric ester hydrolase activity
YP_3379	COG2986	histidine ammonia-lyase
YP_3382	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YP_3385	COG4607	ABC-type enterochelin transport system periplasmic component
YP_3387	COG4605	iron ion homeostasis
YP_3388	COG4604	ABC transporter, ATP-binding protein
YP_3395	COG0582	viral genome integration into host DNA
YP_3396	COG2207	Transcriptional regulator
YP_3396	COG1609	Transcriptional regulator
YP_3397	COG4214	carbohydrate transport
YP_3399	COG4213	ABC transporter substrate-binding protein
YP_3401	COG1070	Carbohydrate kinase
YP_3403	COG3121	Chaperone
YP_3404	COG3188	usher protein
YP_3405	COG3188	usher protein
YP_3407	COG3274	enterobacterial common antigen metabolic process
YP_3409	COG2801	Transposase and inactivated derivatives
YP_3410	COG5001	Diguanylate cyclase
YP_3410	COG3300	MHYT domain
YP_3411	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YP_3420	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
YP_3421	COG2195	Cleaves the N-terminal amino acid of tripeptides
YP_3422	COG4771	TonB-dependent receptor
YP_3423	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YP_3423	COG3433	isochorismatase activity
YP_3423	COG2226	methyltransferase
YP_3424	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YP_3425	COG2226	methyltransferase
YP_3425	COG3433	isochorismatase activity
YP_3425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YP_3431	COG1132	(ABC) transporter
YP_3434	COG2610	gluconate transmembrane transporter activity
YP_3437	COG3501	Rhs element vgr protein
YP_3439	COG3209	COG3209 Rhs family protein
YP_3442	COG0471	metal ion transport
YP_3445	COG2211	Major facilitator Superfamily
YP_3454	COG2771	luxR family
YP_3455	COG3916	Acyl-homoserine-lactone synthase
YP_3478	COG1662	PFAM IS1 transposase
YP_3481	COG1982	Orn Lys Arg decarboxylase major
YP_3482	COG1879	ABC-type sugar transport system periplasmic component
YP_3483	COG1129	ABC transporter
YP_3484	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_3485	COG4774	siderophore transport
YP_3489	COG1194	a g-specific adenine glycosylase
YP_3491	COG3171	Protein conserved in bacteria
YP_3492	COG2066	Belongs to the glutaminase family
YP_3494	COG1073	alpha beta
YP_3494	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
YP_3494	COG3064	Membrane
YP_3495	COG3328	transposase activity
YP_3496	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YP_3497	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
YP_3499	COG0762	integral membrane protein
YP_3500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
YP_3501	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
YP_3502	COG2805	Type II/IV secretion system protein
YP_3504	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YP_3507	COG0189	ligase activity
YP_3508	COG1385	rRNA (uridine-N3-)-methyltransferase activity
YP_3510	COG2356	endonuclease I
YP_3513	COG1166	arginine decarboxylase activity
YP_3515	COG0501	Belongs to the peptidase M48B family
YP_3516	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
YP_3517	COG1943	Transposase
YP_3520	COG0191	fructose-bisphosphate aldolase activity
YP_3525	COG1943	Transposase
YP_3526	COG3119	arylsulfatase activity
YP_3527	COG1349	DNA-binding transcription factor activity
YP_3529	COG2222	sugar isomerase
YP_3530	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YP_3531	COG3715	PTS system
YP_3532	COG3716	PTS system mannose fructose sorbose family IID component
YP_3533	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YP_3535	COG1028	Short-chain dehydrogenase reductase Sdr
YP_3537	COG0641	radical SAM
YP_3538	COG3119	arylsulfatase activity
YP_3540	COG0191	fructose-bisphosphate aldolase activity
YP_3544	COG2271	Major facilitator Superfamily
YP_3549	COG1874	Beta-galactosidase
YP_3550	COG3867	Arabinogalactan endo-beta-1,4-galactanase
YP_3551	COG3833	ABC-type maltose transport systems, permease component
YP_3552	COG1175	transmembrane transport
YP_3553	COG2182	Extracellular solute-binding protein
YP_3555	COG1129	ABC transporter
YP_3556	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_3557	COG1879	ABC-type sugar transport system periplasmic component
YP_3559	COG0791	NLP P60 protein
YP_3561	COG1695	Transcriptional regulator
YP_3579	COG2944	sequence-specific DNA binding
YP_3583	COG0582	viral genome integration into host DNA
YP_3586	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
YP_3587	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YP_3588	COG4974	Belongs to the 'phage' integrase family
YP_3589	COG0716	FMN binding
YP_3590	COG4452	Inner membrane protein CreD
YP_3591	COG2205	protein histidine kinase activity
YP_3592	COG0745	RESPONSE REGULATOR receiver
YP_3594	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
YP_3597	COG1272	protein, Hemolysin III
YP_3605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YP_3606	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YP_3607	COG0006	proline dipeptidase activity
YP_3610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YP_3611	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YP_3612	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YP_3619	COG0494	nUDIX hydrolase
YP_3624	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
YP_3625	COG0849	cell division
YP_3626	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
YP_3630	COG0772	Belongs to the SEDS family
YP_3633	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YP_3634	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YP_3635	COG0768	penicillin binding
YP_3636	COG3116	cell division
YP_3640	COG1609	Transcriptional regulator
YP_3641	COG1943	Transposase
YP_3645	COG1022	Amp-dependent synthetase and ligase
YP_3646	COG0028	Belongs to the TPP enzyme family
YP_3648	COG1943	Transposase
YP_3650	COG0473	3-isopropylmalate dehydrogenase activity
YP_3653	COG2814	Major facilitator Superfamily
YP_3657	COG4143	(ABC) transporter
YP_3658	COG1178	ABC-type Fe3 transport system permease component
YP_3660	COG0586	Pfam SNARE associated Golgi protein
YP_3661	COG0417	DNA replication proofreading
YP_3665	COG2885	chlorophyll binding
YP_3665	COG3047	cAMP biosynthetic process
YP_3672	COG3501	Rhs element vgr protein
YP_3682	COG0564	pseudouridine synthase activity
YP_3683	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
YP_3685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YP_3686	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
YP_3693	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
YP_3695	COG2966	Psort location CytoplasmicMembrane, score
YP_3696	COG1280	lysine exporter protein (LysE YggA)
YP_3697	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
YP_3698	COG0505	Belongs to the CarA family
YP_3700	COG1943	Transposase
YP_3703	COG1047	Peptidyl-prolyl cis-trans
YP_3706	COG0196	riboflavin kinase activity
YP_3709	COG0583	DNA-binding transcription factor activity
YP_3713	COG1584	GPR1 FUN34 yaaH family protein
YP_3716	COG0521	Mo-molybdopterin cofactor biosynthetic process
YP_3725	COG0745	RESPONSE REGULATOR receiver
YP_3726	COG3045	CreA protein
YP_3727	COG2207	Transcriptional regulator
YP_3727	COG3708	Transcriptional regulator
YP_3730	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
YP_3731	COG0741	lytic transglycosylase activity
YP_3734	COG2199	diguanylate cyclase activity
YP_3735	COG2885	chlorophyll binding
YP_3736	COG0488	(ABC) transporter
YP_3740	COG0560	Phosphoserine phosphatase
YP_3741	COG3726	membrane protein affecting hemolysin expression
YP_3745	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YP_3746	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YP_3747	COG0084	hydrolase, TatD family'
YP_3748	COG4667	esterase of the alpha-beta hydrolase superfamily
YP_3750	COG2823	Periplasmic or secreted lipoprotein
YP_3752	COG0456	acetyltransferase
YP_3753	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
YP_3756	COG3706	GGDEF domain
YP_3760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YP_3761	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YP_3765	COG0859	PFAM glycosyl transferase family 9
YP_3767	COG2390	Transcriptional regulator
YP_3776	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YP_3776	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YP_3776	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YP_3777	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YP_3778	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YP_3779	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YP_3780	COG2207	Transcriptional regulator
YP_3782	COG4269	membrane
YP_3794	COG1401	restriction endodeoxyribonuclease activity
YP_3798	COG0583	DNA-binding transcription factor activity
YP_3799	COG1741	Belongs to the pirin family
YP_3801	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
YP_3805	COG2823	Periplasmic or secreted lipoprotein
YP_3807	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
YP_3809	COG5002	protein histidine kinase activity
YP_3809	COG2198	Histidine kinase
YP_3809	COG0784	Response regulator, receiver
YP_3810	COG1242	4 iron, 4 sulfur cluster binding
YP_3811	COG0070	glutamate synthase
YP_3811	COG0069	glutamate synthase activity
YP_3811	COG0067	glutamate synthase
YP_3812	COG0493	'glutamate synthase
YP_3814	COG2969	positive regulation of protein catabolic process
YP_3815	COG0625	glutathione transferase activity
YP_3819	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YP_3820	COG3105	Protein conserved in bacteria
YP_3821	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YP_3822	COG1943	Transposase
YP_3823	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YP_3825	COG5007	Belongs to the BolA IbaG family
YP_3826	COG3113	response to antibiotic
YP_3827	COG2854	intermembrane phospholipid transfer
YP_3828	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YP_3829	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YP_3830	COG1127	ABC transporter
YP_3831	COG0530	calcium, potassium:sodium antiporter activity
YP_3832	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
YP_3832	COG0517	IMP dehydrogenase activity
YP_3833	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
YP_3834	COG3117	lipopolysaccharide transmembrane transporter activity
YP_3835	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
YP_3836	COG1137	ATPase activity
YP_3837	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
YP_3839	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YP_3841	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YP_3846	COG1609	Transcriptional regulator
YP_3847	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YP_3847	COG1263	PTS System
YP_3848	COG0366	Alpha amylase catalytic
YP_3849	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_3850	COG3783	Cytochrome b(562)
YP_3852	COG0312	modulator of DNA gyrase
YP_3854	COG2732	(Barnase) inhibitor
YP_3861	COG0583	DNA-binding transcription factor activity
YP_3874	COG0312	modulator of DNA gyrase
YP_3875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YP_3876	COG3164	Protein of unknown function
YP_3877	COG1530	ribonuclease E activity
YP_3879	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
YP_3880	COG1792	Involved in formation and maintenance of cell shape
YP_3881	COG1077	Cell shape determining protein MreB Mrl
YP_3882	COG2200	EAL domain
YP_3882	COG2199	diguanylate cyclase activity
YP_3883	COG0604	alcohol dehydrogenase
YP_3884	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
YP_3887	COG0511	ligase activity, forming carbon-carbon bonds
YP_3888	COG0439	Biotin carboxylase
YP_3889	COG3924	membrane
YP_3890	COG4145	pantothenate transmembrane transporter activity
YP_3892	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YP_3893	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
YP_3898	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YP_3900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YP_3901	COG3133	Outer membrane lipoprotein
YP_3903	COG1278	Cold shock
YP_3904	COG1278	Cold shock
YP_3905	COG1943	Transposase
YP_3908	COG0625	glutathione transferase activity
YP_3910	COG1069	ribulokinase activity
YP_3912	COG1172	Belongs to the binding-protein-dependent transport system permease family
YP_3913	COG1129	ABC transporter
YP_3915	COG1560	Kdo2-lipid A biosynthetic process
YP_3917	COG0025	NhaP-type Na H and K H
YP_3918	COG2252	PERMEase
YP_3919	COG3077	Addiction module antitoxin, RelB DinJ family
YP_3921	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YP_3924	COG0431	NADPH-dependent FMN reductase
YP_3926	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YP_3927	COG1869	D-ribose catabolic process
YP_3928	COG1917	Cupin 2, conserved barrel domain protein
YP_3928	COG2207	Transcriptional regulator
YP_3929	COG0673	inositol 2-dehydrogenase activity
YP_3931	COG3328	transposase activity
YP_3933	COG3209	COG3209 Rhs family protein
YP_3935	COG3501	Rhs element vgr protein
YP_3941	COG3209	COG3209 Rhs family protein
YP_3944	COG3501	Rhs element vgr protein
YP_3959	COG2801	Transposase and inactivated derivatives
YP_3968	COG2864	formate dehydrogenase
YP_3969	COG0437	4 iron, 4 sulfur cluster binding
YP_3972	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YP_3977	COG3722	fumarate hydratase activity
YP_3979	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
YP_3979	COG2213	PTS system mannitol-specific
YP_3984	COG2818	Glycosylase
YP_3986	COG2885	chlorophyll binding
YP_3989	COG0366	Alpha amylase catalytic
YP_3991	COG3977	Valine--pyruvate aminotransferase
YP_3995	COG5645	(Lipo)protein
YP_3997	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YP_3998	COG2423	ornithine cyclodeaminase activity
YP_4000	COG2801	Transposase and inactivated derivatives
YP_4001	COG0561	phosphatase activity
YP_4002	COG0187	DNA topoisomerase II activity
YP_4003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YP_4004	COG0592	DNA-directed DNA polymerase activity
YP_4007	COG0230	Belongs to the bacterial ribosomal protein bL34 family
YP_4009	COG0706	membrane insertase activity
YP_4014	COG2252	PERMEase
YP_4015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YP_4016	COG0765	amino acid transport
YP_4017	COG0765	amino acid transport
YP_4018	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YP_4020	COG0704	Plays a role in the regulation of phosphate uptake
YP_4022	COG0581	inorganic phosphate transmembrane transporter activity
YP_4023	COG0573	inorganic phosphate transmembrane transporter activity
YP_4024	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YP_4025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YP_4035	COG3312	ion transport
YP_pCD13	COG0515	serine threonine protein kinase
YP_pCD15	COG2801	Transposase and inactivated derivatives
YP_pCD16	COG4372	Transposase
YP_pCD19	COG2801	Transposase and inactivated derivatives
YP_pCD20	COG2963	transposase activity
YP_pCD21	COG5599	Phosphatase
YP_pCD22	COG1317	bacterial-type flagellum organization
YP_pCD24	COG4669	(LipO)protein
YP_pCD34	COG2207	Transcriptional regulator
YP_pCD36	COG4792	protein secretion
YP_pCD37	COG4791	protein targeting
YP_pCD38	COG4794	Type iii secretion
YP_pCD39	COG4790	Type iii secretion
YP_pCD40	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
YP_pCD49	COG4789	Type iii secretion
YP_pCD53	COG0457	Tetratricopeptide repeat
YP_pCD60	COG4886	Leucine-rich repeat (LRR) protein
YP_pCD60	COG4886	Leucine-rich repeat (LRR) protein
YP_pCD67	COG3177	Filamentation induced by cAMP protein fic
YP_pCD72	COG2801	Transposase and inactivated derivatives
YP_pCD74	COG1192	Involved in chromosome partitioning
YP_pCD75	COG1475	DNA binding
YP_pCD78	COG3609	addiction module antidote protein, CC2985 family
YP_pCD81	COG5599	Phosphatase
YP_pCD83	COG2801	Transposase and inactivated derivatives
YP_pCD88	COG2801	Transposase and inactivated derivatives
YP_pCRY04	COG0250	Participates in transcription elongation, termination and antitermination
YP_pCRY14	COG3504	Conjugal transfer protein
YP_pMT003	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
YP_pMT005	COG5301	cellulose 1,4-beta-cellobiosidase activity
YP_pMT005	COG5301	cellulose 1,4-beta-cellobiosidase activity
YP_pMT012	COG3941	tape measure
YP_pMT031	COG1475	DNA binding
YP_pMT032	COG1475	DNA binding
YP_pMT033	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YP_pMT043	COG1943	Transposase
YP_pMT046	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YP_pMT047	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YP_pMT054	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YP_pMT066	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
YP_pMT068	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YP_pMT097	COG1475	DNA binding
YP_pMT120	COG3344	reverse transcriptase
YP_pMT126	COG3328	transposase activity
YP_pPCP10	COG4683	PFAM Phage derived protein Gp49-like (DUF891)