locus-tag	class	description
CH60_10	COG2081	HI0933 family
CH60_1003	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH60_1005	COG1702	phosphate starvation-inducible protein PhoH
CH60_1007	COG4535	Mg2 and Co2 transporter CorC
CH60_1008	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH60_101	COG2146	nitrite reductase [NAD(P)H] activity
CH60_1010	COG0765	amino acid transport
CH60_1011	COG0765	amino acid transport
CH60_1012	COG1126	abc transporter atp-binding protein
CH60_1013	COG2888	peptidyl-tyrosine sulfation
CH60_1016	COG1466	dna polymerase III delta subunit
CH60_1018	COG0799	negative regulation of ribosome biogenesis
CH60_102	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH60_1020	COG0768	penicillin binding
CH60_1021	COG0772	Belongs to the SEDS family
CH60_1022	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH60_1023	COG1686	Belongs to the peptidase S11 family
CH60_1027	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH60_1028	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH60_1029	COG1278	Cold shock
CH60_103	COG0402	S-adenosylhomocysteine deaminase activity
CH60_1030	COG1278	Cold shock
CH60_1031	COG2197	response regulator
CH60_1036	COG5265	(ABC) transporter
CH60_1038	COG3718	enzyme involved in inositol metabolism
CH60_1040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH60_1041	COG0673	inositol 2-dehydrogenase activity
CH60_1042	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_1043	COG1129	ABC transporter
CH60_1044	COG1879	ABC-type sugar transport system periplasmic component
CH60_1045	COG0673	inositol 2-dehydrogenase activity
CH60_1046	COG0673	inositol 2-dehydrogenase activity
CH60_1047	COG3962	Belongs to the TPP enzyme family
CH60_1053	COG2373	Large extracellular alpha-helical protein
CH60_1054	COG4953	penicillin-binding protein 1C
CH60_1055	COG3423	Transcriptional regulator
CH60_1065	COG2850	peptidyl-arginine hydroxylation
CH60_1067	COG3328	transposase activity
CH60_107	COG1486	melibiose metabolic process
CH60_1072	COG0656	L-ascorbic acid biosynthetic process
CH60_1073	COG0667	Aldo Keto reductase
CH60_1077	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH60_1078	COG1943	Transposase
CH60_1079	COG3009	Protein conserved in bacteria
CH60_108	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH60_1080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH60_1080	COG3008	intermembrane lipid transfer
CH60_1081	COG2995	paraquat-inducible protein a
CH60_1082	COG0488	(ABC) transporter
CH60_1084	COG3217	Mosc domain protein beta barrel domain protein
CH60_1084	COG0633	Ferredoxin
CH60_1087	COG0308	aminopeptidase N
CH60_109	COG0433	COG0433 Predicted ATPase
CH60_1091	COG1448	Aminotransferase
CH60_1092	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH60_1093	COG3108	Peptidase M15
CH60_1094	COG2989	Protein conserved in bacteria
CH60_1095	COG1943	Transposase
CH60_1097	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CH60_1098	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH60_1099	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH60_11	COG0306	phosphate transporter
CH60_1100	COG3173	Aminoglycoside phosphotransferase
CH60_1102	COG2835	tetraacyldisaccharide 4'-kinase activity
CH60_1103	COG1278	Cold shock
CH60_1104	COG5383	Protein conserved in bacteria
CH60_1107	COG2333	competence protein COMEC
CH60_1107	COG0658	competence protein
CH60_1110	COG0539	negative regulation of cytoplasmic translation
CH60_1115	COG5295	Hep Hag repeat protein
CH60_1115	COG5295	Hep Hag repeat protein
CH60_1116	COG0252	asparaginase activity
CH60_1117	COG1944	ATP diphosphatase activity
CH60_1118	COG2116	formate transmembrane transporter activity
CH60_1119	COG1882	Formate acetyltransferase
CH60_112	COG1289	transmembrane transporter activity
CH60_1121	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH60_1122	COG2814	Major facilitator Superfamily
CH60_1124	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH60_1127	COG1674	ftsk spoiiie
CH60_1127	COG3107	peptidoglycan biosynthetic process
CH60_1129	COG0492	ferredoxin-NADP+ reductase activity
CH60_1131	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH60_1133	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH60_1134	COG1943	Transposase
CH60_1135	COG0542	response to heat
CH60_1137	COG1278	Cold shock
CH60_1139	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH60_114	COG1765	OsmC-like protein
CH60_1140	COG2990	Protein conserved in bacteria
CH60_1141	COG3593	DNA synthesis involved in DNA repair
CH60_1142	COG2431	L-lysine efflux transmembrane transporter activity
CH60_1144	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH60_1145	COG0028	Belongs to the TPP enzyme family
CH60_1146	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH60_1147	COG0702	epimerase
CH60_1148	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH60_1150	COG1605	Chorismate mutase
CH60_1151	COG1126	abc transporter atp-binding protein
CH60_1152	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH60_1153	COG4215	(ABC) transporter
CH60_1154	COG4160	amino acid transport
CH60_1158	COG1120	ATPase activity
CH60_1159	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH60_116	COG3954	Phosphoribulokinase
CH60_1164	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH60_1167	COG1177	transmembrane transport
CH60_1168	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH60_1169	COG3842	ATPase activity
CH60_1170	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH60_1173	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH60_1174	COG2985	domain, Protein
CH60_1174	COG0569	domain protein
CH60_1176	COG0671	phosphoesterase, PA-phosphatase related
CH60_1177	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH60_1178	COG1349	DNA-binding transcription factor activity
CH60_1179	COG0814	amino acid
CH60_118	COG0429	hydrolase of the alpha beta-hydrolase fold
CH60_1180	COG1686	Belongs to the peptidase S11 family
CH60_1181	COG2011	ABC-type metal ion transport system permease component
CH60_1186	COG0625	glutathione transferase activity
CH60_1187	COG4771	TonB-dependent receptor
CH60_1189	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH60_1191	COG0833	amino acid
CH60_1193	COG0583	DNA-binding transcription factor activity
CH60_1194	COG2855	membrane
CH60_1195	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CH60_12	COG1943	Transposase
CH60_120	COG4521	taurine ABC transporter
CH60_1203	COG0288	reversible hydration of carbon dioxide
CH60_122	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH60_1221	COG0840	transmembrane signaling receptor activity
CH60_1223	COG0583	DNA-binding transcription factor activity
CH60_1224	COG0583	DNA-binding transcription factor activity
CH60_1225	COG2814	Major facilitator Superfamily
CH60_1226	COG1609	Transcriptional regulator
CH60_1227	COG0019	diaminopimelate decarboxylase activity
CH60_123	COG2175	clavaminate synthase activity
CH60_1233	COG0667	Aldo Keto reductase
CH60_1244	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH60_1246	COG1074	ATP-dependent DNA helicase activity
CH60_1247	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH60_1249	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH60_1252	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH60_1253	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH60_1254	COG2166	iron-sulfur cluster assembly
CH60_1255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH60_1257	COG0583	DNA-binding transcription factor activity
CH60_1258	COG2363	Small membrane protein
CH60_126	COG1216	Glycosyl transferase, family 2
CH60_1260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH60_1261	COG1611	Belongs to the LOG family
CH60_1264	COG1943	Transposase
CH60_1265	COG3098	single-species biofilm formation
CH60_1266	COG0564	pseudouridine synthase activity
CH60_127	COG0488	(ABC) transporter
CH60_1271	COG0024	Methionine aminopeptidase
CH60_1277	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CH60_1278	COG0575	Belongs to the CDS family
CH60_1279	COG0750	zinc metalloprotease
CH60_1281	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH60_1285	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH60_1287	COG0587	DNA-directed DNA polymerase activity
CH60_1289	COG0346	lactoylglutathione lyase activity
CH60_1290	COG0037	tRNA processing
CH60_1292	COG4568	rho-dependent transcription termination
CH60_1294	COG4681	YaeQ
CH60_1296	COG3015	lipoprotein NlpE involved in copper resistance
CH60_1298	COG1720	tRNA m6t6A37 methyltransferase activity
CH60_130	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH60_1300	COG1464	Belongs to the NlpA lipoprotein family
CH60_1301	COG2011	ABC-type metal ion transport system permease component
CH60_1303	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH60_131	COG1047	Peptidyl-prolyl cis-trans
CH60_1310	COG0656	L-ascorbic acid biosynthetic process
CH60_1313	COG1388	LysM domain
CH60_1313	COG0741	lytic transglycosylase activity
CH60_1315	COG2226	methyltransferase
CH60_1317	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH60_1319	COG1953	Uracil, thiamine, allantoin
CH60_1326	COG2113	Glycine betaine
CH60_1327	COG4176	ABC-type proline glycine betaine transport system permease component
CH60_1328	COG4175	Glycine betaine
CH60_1329	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH60_133	COG0545	Peptidyl-prolyl cis-trans isomerase
CH60_1335	COG3328	transposase activity
CH60_1336	COG3188	usher protein
CH60_134	COG2964	Protein conserved in bacteria
CH60_1348	COG3501	Rhs element vgr protein
CH60_1354	COG3328	transposase activity
CH60_1355	COG3328	transposase activity
CH60_1358	COG0351	phosphomethylpyrimidine kinase
CH60_1363	COG3422	double-strand break repair
CH60_1364	COG0745	RESPONSE REGULATOR receiver
CH60_1365	COG2205	protein histidine kinase activity
CH60_1370	COG3842	ATPase activity
CH60_1372	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CH60_1374	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH60_1375	COG1177	transmembrane transport
CH60_1376	COG0443	Heat shock 70 kDa protein
CH60_1377	COG2239	Acts as a magnesium transporter
CH60_1378	COG0248	Ppx GppA phosphatase
CH60_1379	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH60_138	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH60_1381	COG0581	inorganic phosphate transmembrane transporter activity
CH60_1385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH60_1386	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH60_1389	COG1943	Transposase
CH60_139	COG0049	tRNA binding
CH60_1391	COG1393	Belongs to the ArsC family
CH60_1392	COG4783	chaperone-mediated protein folding
CH60_1393	COG0628	permease
CH60_1396	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH60_1397	COG2716	regulation of RNA biosynthetic process
CH60_1399	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH60_14	COG0589	response to stress
CH60_1400	COG1943	Transposase
CH60_1402	COG2321	neutral zinc metallopeptidase
CH60_1406	COG1876	peptidase activity
CH60_1408	COG1393	Belongs to the ArsC family
CH60_1410	COG1840	ABC-type Fe3 transport system, periplasmic component
CH60_1411	COG1175	transmembrane transport
CH60_1412	COG3842	ATPase activity
CH60_1413	COG3119	arylsulfatase activity
CH60_1414	COG0641	radical SAM
CH60_1415	COG1988	membrane-bound metal-dependent
CH60_1417	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH60_1419	COG2197	response regulator
CH60_142	COG1943	Transposase
CH60_1420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH60_1420	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH60_1421	COG3062	negative regulation of establishment of protein localization
CH60_1423	COG3043	anaerobic respiration
CH60_1424	COG3005	denitrification pathway
CH60_1433	COG3111	PFAM Bacterial OB fold (BOF) protein
CH60_1435	COG2837	iron assimilation
CH60_1436	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH60_1438	COG4886	Leucine-rich repeat (LRR) protein
CH60_1440	COG2731	YhcH YjgK YiaL family protein
CH60_1441	COG1737	Transcriptional regulator
CH60_1443	COG4150	thiosulfate binding
CH60_1444	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH60_1445	COG4208	sulfate ABC transporter
CH60_1446	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CH60_1449	COG0745	RESPONSE REGULATOR receiver
CH60_1450	COG3850	Histidine kinase
CH60_1450	COG5002	protein histidine kinase activity
CH60_1452	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH60_1454	COG0006	proline dipeptidase activity
CH60_1456	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH60_1459	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH60_146	COG0051	transcription antitermination factor activity, RNA binding
CH60_1460	COG0745	RESPONSE REGULATOR receiver
CH60_1461	COG2205	protein histidine kinase activity
CH60_1463	COG1943	Transposase
CH60_1464	COG2190	(PTS) system
CH60_1466	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH60_1467	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CH60_1468	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CH60_1471	COG3530	Putative quorum-sensing-regulated virulence factor
CH60_1480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH60_1483	COG0667	Aldo Keto reductase
CH60_1488	COG0436	Aminotransferase
CH60_1489	COG3038	cytochrome b561
CH60_1495	COG3381	protein complex oligomerization
CH60_1496	COG3302	dmso reductase anchor subunit
CH60_1497	COG0437	4 iron, 4 sulfur cluster binding
CH60_1498	COG0243	molybdopterin cofactor binding
CH60_1505	COG2951	lytic endotransglycosylase activity
CH60_151	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH60_1517	COG3121	Chaperone
CH60_1518	COG3188	usher protein
CH60_1519	COG3328	transposase activity
CH60_1522	COG1278	Cold shock
CH60_1523	COG0747	negative chemotaxis
CH60_1525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH60_1526	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH60_1527	COG1124	(ABC) transporter
CH60_153	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CH60_1534	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH60_1536	COG4413	Urea transporter
CH60_1537	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH60_1539	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH60_154	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH60_1540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH60_1541	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH60_1542	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH60_1543	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH60_1544	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH60_1545	COG1917	Cupin 2, conserved barrel domain protein
CH60_1545	COG2169	Transcriptional regulator
CH60_1549	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH60_1550	COG0033	Phosphoglucomutase
CH60_1554	COG0745	RESPONSE REGULATOR receiver
CH60_1555	COG2205	protein histidine kinase activity
CH60_156	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH60_1560	COG3272	Protein of unknown function (DUF1722)
CH60_1562	COG5212	phosphodiesterase
CH60_1563	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH60_1565	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH60_1566	COG1984	allophanate hydrolase subunit 2
CH60_157	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH60_1580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH60_1582	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH60_1583	COG3026	antisigma factor binding
CH60_1584	COG3086	response to oxidative stress
CH60_1587	COG0681	Belongs to the peptidase S26 family
CH60_1591	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH60_1593	COG1943	Transposase
CH60_1594	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH60_1595	COG1737	Transcriptional regulator
CH60_1600	COG1737	Transcriptional regulator
CH60_1602	COG0560	Phosphoserine phosphatase
CH60_1603	COG0590	tRNA wobble adenosine to inosine editing
CH60_1609	COG1943	Transposase
CH60_1610	COG2205	protein histidine kinase activity
CH60_1611	COG3170	Tfp pilus assembly protein FimV
CH60_1612	COG2204	response regulator
CH60_1613	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH60_1613	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH60_1614	COG0347	Belongs to the P(II) protein family
CH60_1617	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH60_1617	COG1017	nitric oxide dioxygenase activity
CH60_1620	COG3711	transcriptional antiterminator
CH60_1621	COG2814	Major facilitator Superfamily
CH60_1622	COG3683	transport system, periplasmic component
CH60_1623	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH60_1624	COG0483	inositol monophosphate 1-phosphatase activity
CH60_1627	COG1104	cysteine desulfurase activity
CH60_1628	COG0822	iron-sulfur transferase activity
CH60_1631	COG0443	Heat shock 70 kDa protein
CH60_1632	COG0633	Ferredoxin
CH60_1633	COG2975	iron-sulfur cluster assembly
CH60_1637	COG3468	outer membrane autotransporter barrel domain protein
CH60_1638	COG3468	outer membrane autotransporter barrel domain protein
CH60_1647	COG2976	Protein conserved in bacteria
CH60_1648	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH60_165	COG1841	ribosomal large subunit assembly
CH60_1651	COG1645	bacterial-type flagellum-dependent swarming motility
CH60_1653	COG0516	GMP reductase activity
CH60_1653	COG0517	IMP dehydrogenase activity
CH60_1655	COG1943	Transposase
CH60_1662	COG3328	transposase activity
CH60_1663	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH60_1666	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH60_1667	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH60_1668	COG1121	(ABC) transporter
CH60_1669	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH60_167	COG0201	protein transport
CH60_1673	COG4249	Peptidase C14 caspase catalytic subunit p20
CH60_1678	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CH60_1679	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH60_1679	COG0072	phenylalanine-tRNA ligase activity
CH60_168	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH60_1680	COG0776	regulation of translation
CH60_1683	COG0386	Belongs to the glutathione peroxidase family
CH60_1684	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH60_1692	COG0791	NLP P60 protein
CH60_1698	COG0574	Belongs to the PEP-utilizing enzyme family
CH60_1698	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH60_1699	COG0628	permease
CH60_1700	COG0247	lactate metabolic process
CH60_1700	COG0277	FAD linked oxidase domain protein
CH60_1701	COG2050	protein possibly involved in aromatic compounds catabolism
CH60_1702	COG0316	Belongs to the HesB IscA family
CH60_1703	COG0719	Fe-S assembly protein
CH60_1704	COG0396	ATPase activity
CH60_1705	COG0719	Fe-S assembly protein
CH60_1708	COG1376	ErfK ybiS ycfS ynhG family protein
CH60_1708	COG1388	LysM domain
CH60_171	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH60_1712	COG1943	Transposase
CH60_1713	COG4238	major outer membrane lipoprotein
CH60_1718	COG0307	riboflavin synthase, alpha
CH60_1719	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH60_1720	COG2814	Major facilitator Superfamily
CH60_1721	COG0583	DNA-binding transcription factor activity
CH60_1724	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH60_1725	COG0791	NLP P60 protein
CH60_1727	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH60_1728	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH60_1729	COG0346	lactoylglutathione lyase activity
CH60_1731	COG1902	pentaerythritol trinitrate reductase activity
CH60_1732	COG1309	transcriptional regulator
CH60_1733	COG2194	sulfuric ester hydrolase activity
CH60_1734	COG3313	Fe-S protein
CH60_1735	COG4989	oxidoreductase activity
CH60_1737	COG3133	Outer membrane lipoprotein
CH60_1739	COG3895	Periplasmic Protein
CH60_174	COG0789	Transcriptional regulator
CH60_1743	COG0625	glutathione transferase activity
CH60_1746	COG3104	oligopeptide transport
CH60_1748	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH60_1748	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH60_1749	COG4172	Belongs to the ABC transporter superfamily
CH60_175	COG3036	rescue of stalled ribosome
CH60_1751	COG4171	peptide transport system, permease
CH60_1752	COG4168	peptide transport system, permease
CH60_1753	COG4166	transmembrane transport
CH60_1754	COG1943	Transposase
CH60_1759	COG3106	COG3106 Predicted ATPase
CH60_1761	COG1983	PspC domain protein
CH60_1763	COG1842	Phage shock protein A
CH60_1764	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH60_1765	COG1943	Transposase
CH60_1766	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH60_1767	COG4948	Mandelate Racemase Muconate Lactonizing
CH60_1768	COG2866	Carboxypeptidase
CH60_1769	COG4166	transmembrane transport
CH60_177	COG0569	domain protein
CH60_1772	COG0657	acetylesterase activity
CH60_1772	COG2755	lipolytic protein G-D-S-L family
CH60_1775	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH60_1775	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH60_1775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH60_1775	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH60_1777	COG1285	pathogenesis
CH60_1778	COG3042	response to heat
CH60_1779	COG3187	Heat shock protein
CH60_1780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH60_1781	COG2911	Protein conserved in bacteria
CH60_1783	COG3784	Protein of unknown function (DUF1318)
CH60_1784	COG0246	Mannitol dehydrogenase
CH60_1785	COG2390	Transcriptional regulator
CH60_1787	COG1643	Atp-dependent helicase
CH60_1790	COG3591	Belongs to the peptidase S1B family
CH60_1792	COG3038	cytochrome b561
CH60_1796	COG1943	Transposase
CH60_1797	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH60_1798	COG2205	protein histidine kinase activity
CH60_1799	COG0745	RESPONSE REGULATOR receiver
CH60_18	COG0339	signal peptide processing
CH60_1801	COG0531	amino acid
CH60_1803	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH60_1804	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH60_1805	COG0589	response to stress
CH60_1806	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH60_1807	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH60_181	COG0758	DNA mediated transformation
CH60_1811	COG1011	Hydrolase
CH60_1812	COG0440	acetolactate synthase activity
CH60_1813	COG0028	Belongs to the TPP enzyme family
CH60_1818	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH60_1820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH60_1821	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH60_1822	COG1879	ABC-type sugar transport system periplasmic component
CH60_1824	COG1609	Transcriptional regulator
CH60_1825	COG0038	chloride channel
CH60_1826	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH60_1828	COG1940	carbohydrate kinase activity
CH60_1829	COG0583	DNA-binding transcription factor activity
CH60_183	COG0551	DNA topoisomerase type I activity
CH60_1830	COG2814	Major facilitator Superfamily
CH60_1832	COG0114	fumarate hydratase activity
CH60_1834	COG5339	Protein conserved in bacteria
CH60_1836	COG0385	Bile acid
CH60_1837	COG0673	inositol 2-dehydrogenase activity
CH60_1839	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_1841	COG1879	ABC-type sugar transport system periplasmic component
CH60_1845	COG2274	protein secretion by the type I secretion system
CH60_1846	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH60_1853	COG3708	Transcriptional regulator
CH60_1853	COG2207	Transcriptional regulator
CH60_1854	COG4658	electron transport chain
CH60_1855	COG4659	FMN binding
CH60_1857	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH60_1858	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH60_1859	COG2271	Major facilitator Superfamily
CH60_186	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH60_1861	COG1966	Carbon starvation protein
CH60_1862	COG2879	small protein
CH60_1863	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH60_1867	COG0023	Translation Initiation Factor
CH60_1870	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH60_1871	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH60_1872	COG0671	phosphoesterase, PA-phosphatase related
CH60_1873	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH60_1874	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CH60_1876	COG0583	DNA-binding transcription factor activity
CH60_1877	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH60_1880	COG0616	signal peptide processing
CH60_1881	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_1883	COG1187	pseudouridine synthase activity
CH60_1884	COG0009	L-threonylcarbamoyladenylate synthase
CH60_1887	COG0512	Glutamine amidotransferase of anthranilate synthase
CH60_1889	COG0134	indole-3-glycerol-phosphate synthase activity
CH60_1889	COG0135	phosphoribosylanthranilate isomerase activity
CH60_1893	COG3047	cAMP biosynthetic process
CH60_1898	COG1607	acyl-coa hydrolase
CH60_1899	COG3328	transposase activity
CH60_19	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH60_1900	COG3328	transposase activity
CH60_1901	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH60_1903	COG2350	Protein conserved in bacteria
CH60_1910	COG4608	Belongs to the ABC transporter superfamily
CH60_1911	COG0444	Belongs to the ABC transporter superfamily
CH60_1912	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH60_1913	COG0601	transmembrane transport
CH60_1915	COG2095	MarC family integral membrane protein
CH60_1916	COG1012	belongs to the aldehyde dehydrogenase family
CH60_1916	COG1454	alcohol dehydrogenase
CH60_1917	COG1435	thymidine kinase activity
CH60_1920	COG0745	RESPONSE REGULATOR receiver
CH60_1922	COG0788	formyltetrahydrofolate deformylase activity
CH60_1925	COG0583	DNA-binding transcription factor activity
CH60_1926	COG0708	Exodeoxyribonuclease III
CH60_1927	COG0494	nUDIX hydrolase
CH60_1929	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH60_1930	COG0709	Synthesizes selenophosphate from selenide and ATP
CH60_1931	COG0778	Nitroreductase
CH60_1932	COG0616	signal peptide processing
CH60_1933	COG0252	asparaginase activity
CH60_1934	COG1335	isochorismatase
CH60_1935	COG3139	Protein of unknown function (DUF1315)
CH60_1939	COG3713	MltA-interacting MipA family protein
CH60_194	COG2801	Transposase and inactivated derivatives
CH60_1940	COG2766	serine protein kinase
CH60_1943	COG0583	DNA-binding transcription factor activity
CH60_1945	COG2814	Major facilitator Superfamily
CH60_1947	COG2719	SpoVR family
CH60_1953	COG1104	cysteine desulfurase activity
CH60_1955	COG3328	transposase activity
CH60_1957	COG3328	transposase activity
CH60_1968	COG0582	viral genome integration into host DNA
CH60_1970	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH60_1971	COG2951	lytic endotransglycosylase activity
CH60_1974	COG2894	cell division
CH60_1975	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH60_1976	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH60_1977	COG0318	PFAM AMP-dependent synthetase and ligase
CH60_1978	COG3065	identical protein binding
CH60_1980	COG1199	ATP-dependent helicase activity
CH60_1981	COG0251	oxidation-reduction process
CH60_1984	COG0800	Aldolase
CH60_1986	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH60_1987	COG1737	Transcriptional regulator
CH60_1988	COG0469	pyruvate kinase activity
CH60_1989	COG1560	Kdo2-lipid A biosynthetic process
CH60_1990	COG0739	heme binding
CH60_1991	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH60_1993	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH60_1998	COG0494	nUDIX hydrolase
CH60_2	COG0745	RESPONSE REGULATOR receiver
CH60_20	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH60_2000	COG3328	transposase activity
CH60_2001	COG3328	transposase activity
CH60_2002	COG1801	Protein of unknown function DUF72
CH60_2003	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH60_2007	COG3102	Protein conserved in bacteria
CH60_201	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH60_2012	COG0728	peptidoglycan biosynthetic process
CH60_2013	COG0673	inositol 2-dehydrogenase activity
CH60_2014	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH60_2017	COG3381	protein complex oligomerization
CH60_202	COG0360	Binds together with S18 to 16S ribosomal RNA
CH60_2020	COG1940	carbohydrate kinase activity
CH60_2021	COG0584	glycerophosphoryl diester phosphodiesterase
CH60_2022	COG3842	ATPase activity
CH60_2023	COG1943	Transposase
CH60_2025	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH60_2026	COG3833	ABC-type maltose transport systems, permease component
CH60_2030	COG0659	secondary active sulfate transmembrane transporter activity
CH60_2032	COG2912	Transglutaminase-like superfamily
CH60_2033	COG3094	Invasion gene expression up-regulator, SirB
CH60_2034	COG2890	protein-(glutamine-N5) methyltransferase activity
CH60_2039	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH60_204	COG1073	alpha beta
CH60_2042	COG0012	GTP binding
CH60_205	COG3650	response to hydrogen peroxide
CH60_2053	COG5002	protein histidine kinase activity
CH60_206	COG1960	acyl-CoA dehydrogenase activity
CH60_2062	COG0500	methyltransferase
CH60_2067	COG3328	transposase activity
CH60_207	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH60_2075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH60_2076	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CH60_2077	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CH60_208	COG0557	exoribonuclease II activity
CH60_2080	COG0402	S-adenosylhomocysteine deaminase activity
CH60_2090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH60_2091	COG3328	transposase activity
CH60_2093	COG5295	Hep Hag repeat protein
CH60_2095	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH60_2096	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH60_2097	COG0745	RESPONSE REGULATOR receiver
CH60_2099	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH60_21	COG3835	regulator
CH60_2100	COG0840	transmembrane signaling receptor activity
CH60_2101	COG0840	transmembrane signaling receptor activity
CH60_2105	COG2964	Protein conserved in bacteria
CH60_2107	COG0251	oxidation-reduction process
CH60_2108	COG2271	Major facilitator Superfamily
CH60_2109	COG0835	chemotaxis
CH60_211	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH60_2110	COG2198	Histidine kinase
CH60_2110	COG0643	Histidine kinase
CH60_2111	COG1360	Flagellar Motor Protein
CH60_2116	COG1285	pathogenesis
CH60_2117	COG0840	transmembrane signaling receptor activity
CH60_2118	COG0840	transmembrane signaling receptor activity
CH60_212	COG0330	HflC and HflK could
CH60_2120	COG1278	Cold shock
CH60_2122	COG0604	alcohol dehydrogenase
CH60_2122	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_2122	COG3321	synthase
CH60_2124	COG1522	sequence-specific DNA binding
CH60_2129	COG1733	regulation of RNA biosynthetic process
CH60_213	COG0330	HflC and HflK could
CH60_2130	COG0702	epimerase
CH60_2131	COG0840	transmembrane signaling receptor activity
CH60_2134	COG0538	isocitrate dehydrogenase activity
CH60_2135	COG1187	pseudouridine synthase activity
CH60_2139	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH60_214	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH60_2141	COG0745	RESPONSE REGULATOR receiver
CH60_2143	COG2850	peptidyl-arginine hydroxylation
CH60_2145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH60_2147	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH60_2149	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH60_2150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH60_2151	COG3134	Outer membrane lipoprotein
CH60_2152	COG3328	transposase activity
CH60_2153	COG3328	transposase activity
CH60_2156	COG1252	NADH dehydrogenase
CH60_2158	COG1472	Belongs to the glycosyl hydrolase 3 family
CH60_2161	COG5633	Lipoprotein
CH60_2162	COG0537	adenosine 5'-monophosphoramidase activity
CH60_2163	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH60_2164	COG1943	Transposase
CH60_2165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH60_2165	COG1263	PTS System
CH60_2166	COG0084	hydrolase, TatD family'
CH60_2167	COG0470	DNA polymerase III
CH60_2169	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH60_2170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH60_2171	COG1943	Transposase
CH60_2172	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH60_2174	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_2178	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH60_2179	COG1399	metal-binding, possibly nucleic acid-binding protein
CH60_218	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH60_2181	COG0564	pseudouridine synthase activity
CH60_2182	COG1530	ribonuclease E activity
CH60_2183	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH60_2186	COG3328	transposase activity
CH60_219	COG0802	atpase or kinase
CH60_2190	COG0628	permease
CH60_2194	COG2771	luxR family
CH60_2195	COG3916	Acyl-homoserine-lactone synthase
CH60_2196	COG0583	DNA-binding transcription factor activity
CH60_2198	COG0477	Major facilitator Superfamily
CH60_22	COG2610	gluconate transmembrane transporter activity
CH60_220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH60_220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH60_2200	COG0667	Aldo Keto reductase
CH60_2205	COG1203	CRISPR-associated helicase, Cas3
CH60_2206	COG1518	maintenance of DNA repeat elements
CH60_2207	COG0668	transmembrane transport
CH60_221	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH60_2211	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CH60_2212	COG0395	ABC-type sugar transport system, permease component
CH60_2215	COG1609	Transcriptional regulator
CH60_2217	COG1943	Transposase
CH60_2218	COG3842	ATPase activity
CH60_2220	COG3210	domain, Protein
CH60_2224	COG3210	domain, Protein
CH60_2225	COG2831	hemolysin activation secretion protein
CH60_2226	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH60_2227	COG4638	Rieske (2fe-2S)
CH60_2228	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CH60_2229	COG0473	3-isopropylmalate dehydrogenase activity
CH60_2230	COG0583	DNA-binding transcription factor activity
CH60_2231	COG1609	Transcriptional regulator
CH60_2232	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_2233	COG1129	ABC transporter
CH60_2234	COG1879	ABC-type sugar transport system periplasmic component
CH60_2235	COG1063	alcohol dehydrogenase
CH60_2239	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH60_2245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH60_2246	COG0765	amino acid transport
CH60_2247	COG1126	abc transporter atp-binding protein
CH60_225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH60_2251	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH60_2254	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH60_2257	COG1169	isochorismate synthase
CH60_2259	COG4575	ribosome binding
CH60_2261	COG0129	dihydroxy-acid dehydratase activity
CH60_2265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH60_2266	COG1609	Transcriptional regulator
CH60_2268	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_2269	COG3265	gluconokinase activity
CH60_2270	COG2731	YhcH YjgK YiaL family protein
CH60_2273	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH60_2274	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH60_2276	COG0839	Belongs to the complex I subunit 6 family
CH60_2279	COG1034	ATP synthesis coupled electron transport
CH60_228	COG1511	domain protein
CH60_228	COG3264	Mechanosensitive ion channel
CH60_2281	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CH60_2283	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH60_2285	COG0583	DNA-binding transcription factor activity
CH60_2286	COG0436	Aminotransferase
CH60_2288	COG0471	metal ion transport
CH60_2288	COG0490	domain, Protein
CH60_2289	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH60_2293	COG0857	belongs to the CobB CobQ family
CH60_2293	COG0280	phosphate acetyltransferase
CH60_2294	COG1609	Transcriptional regulator
CH60_2297	COG3328	transposase activity
CH60_23	COG1929	Belongs to the glycerate kinase type-1 family
CH60_230	COG1053	succinate dehydrogenase
CH60_2302	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH60_2303	COG0622	Phosphoesterase
CH60_2305	COG1090	epimerase
CH60_2306	COG4598	ABC transporter
CH60_2307	COG4160	amino acid transport
CH60_2308	COG4215	(ABC) transporter
CH60_2309	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH60_231	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH60_2310	COG0163	prenyltransferase activity
CH60_2311	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH60_2312	COG1286	toxin biosynthetic process
CH60_2313	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH60_2314	COG0285	dihydrofolate synthase activity
CH60_2316	COG0586	Pfam SNARE associated Golgi protein
CH60_2318	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH60_2321	COG0697	spore germination
CH60_2324	COG1794	racemase activity, acting on amino acids and derivatives
CH60_2325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH60_2328	COG3101	peptidyl-lysine hydroxylation
CH60_2329	COG0730	response to heat
CH60_233	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH60_2332	COG2890	protein-(glutamine-N5) methyltransferase activity
CH60_2334	COG2062	phosphohistidine phosphatase, SixA
CH60_2337	COG3691	Protein conserved in bacteria
CH60_234	COG2076	Multidrug Resistance protein
CH60_2340	COG4235	cytochrome complex assembly
CH60_2340	COG3088	subunit of a heme lyase
CH60_2341	COG3088	subunit of a heme lyase
CH60_2341	COG4235	cytochrome complex assembly
CH60_2342	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH60_2343	COG1138	Cytochrome C-type biogenesis protein
CH60_2345	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH60_2346	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH60_2347	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH60_2351	COG1704	LemA family
CH60_2353	COG2824	Alkylphosphonate utilization operon protein PhnA
CH60_2354	COG3328	transposase activity
CH60_2355	COG1917	Cupin 2, conserved barrel domain protein
CH60_2357	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_2359	COG1175	transmembrane transport
CH60_2362	COG3842	ATPase activity
CH60_2363	COG1653	transport
CH60_2364	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH60_2365	COG1988	membrane-bound metal-dependent
CH60_2367	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH60_2369	COG0823	Involved in the tonB-independent uptake of proteins
CH60_2370	COG2814	Major facilitator Superfamily
CH60_2371	COG3121	Chaperone
CH60_2374	COG3121	Chaperone
CH60_2375	COG3539	Fimbrial protein
CH60_2378	COG0793	Belongs to the peptidase S41A family
CH60_2380	COG1956	GAF domain-containing protein
CH60_2381	COG2995	paraquat-inducible protein a
CH60_2382	COG3008	intermembrane lipid transfer
CH60_2386	COG3121	Chaperone
CH60_2406	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH60_2407	COG3850	Histidine kinase
CH60_2408	COG0387	Pfam Sodium calcium exchanger
CH60_2409	COG1702	phosphate starvation-inducible protein PhoH
CH60_2412	COG3658	cytochrome
CH60_2413	COG1215	transferase activity, transferring glycosyl groups
CH60_2414	COG0726	polysaccharide deacetylase
CH60_2414	COG1649	PFAM Uncharacterised BCR, COG1649
CH60_2415	COG0457	Tetratricopeptide repeat
CH60_2416	COG0006	proline dipeptidase activity
CH60_242	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH60_2420	COG0577	efflux transmembrane transporter activity
CH60_2420	COG1136	(ABC) transporter
CH60_2422	COG0577	efflux transmembrane transporter activity
CH60_2422	COG1136	(ABC) transporter
CH60_2425	COG0672	)-iron permease
CH60_2427	COG2066	Belongs to the glutaminase family
CH60_2428	COG1349	DNA-binding transcription factor activity
CH60_2430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH60_2431	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH60_2439	COG2030	dehydratase
CH60_2440	COG0427	acetyl-CoA hydrolase
CH60_2447	COG3188	usher protein
CH60_2449	COG3121	Chaperone
CH60_245	COG3383	formate dehydrogenase (NAD+) activity
CH60_2451	COG0582	viral genome integration into host DNA
CH60_2452	COG1169	isochorismate synthase
CH60_2453	COG2814	Major facilitator Superfamily
CH60_2454	COG1132	(ABC) transporter
CH60_2457	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH60_2457	COG3433	isochorismatase activity
CH60_2457	COG2226	methyltransferase
CH60_246	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH60_2461	COG1021	2,3-dihydroxybenzoate-AMP ligase
CH60_2462	COG4771	TonB-dependent receptor
CH60_247	COG0493	'glutamate synthase
CH60_247	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH60_2475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH60_2478	COG1067	ATP-dependent peptidase activity
CH60_248	COG1309	transcriptional regulator
CH60_2480	COG1943	Transposase
CH60_2482	COG3082	Protein of unknown function (DUF1414)
CH60_2483	COG3083	sulfuric ester hydrolase activity
CH60_2486	COG3157	Type VI secretion system effector, Hcp
CH60_2490	COG3328	transposase activity
CH60_2491	COG3328	transposase activity
CH60_2492	COG0513	Belongs to the DEAD box helicase family
CH60_2493	COG1943	Transposase
CH60_2495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH60_2497	COG1686	Belongs to the peptidase S11 family
CH60_2498	COG0277	FAD linked oxidase domain protein
CH60_2500	COG1403	HNH endonuclease
CH60_2502	COG2261	transglycosylase associated protein
CH60_2504	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CH60_2507	COG4807	Protein conserved in bacteria
CH60_2511	COG1122	ATPase activity
CH60_2512	COG0410	ABC transporter
CH60_2515	COG2897	thiosulfate sulfurtransferase activity
CH60_2518	COG1174	glycine betaine transport
CH60_2519	COG1125	glycine betaine transport
CH60_2520	COG1174	glycine betaine transport
CH60_2521	COG0531	amino acid
CH60_2522	COG1982	Orn Lys Arg decarboxylase major
CH60_2524	COG0697	spore germination
CH60_2529	COG0814	amino acid
CH60_2532	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH60_2537	COG0784	Response regulator, receiver
CH60_2537	COG2205	protein histidine kinase activity
CH60_2539	COG2198	Histidine kinase
CH60_2539	COG0642	Histidine kinase
CH60_2540	COG0642	Histidine kinase
CH60_2540	COG2198	Histidine kinase
CH60_2541	COG2223	nitrite transmembrane transporter activity
CH60_2543	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH60_2546	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH60_2554	COG3395	kinase activity
CH60_2555	COG0235	Class ii aldolase
CH60_2556	COG1349	DNA-binding transcription factor activity
CH60_2557	COG3622	Belongs to the hyi family
CH60_2561	COG4386	tail sheath protein
CH60_2569	COG3299	homolog of phage Mu protein gp47
CH60_2573	COG1737	Transcriptional regulator
CH60_2575	COG2723	6-phospho-beta-galactosidase activity
CH60_2576	COG3328	transposase activity
CH60_2582	COG0513	Belongs to the DEAD box helicase family
CH60_2583	COG1309	transcriptional regulator
CH60_2585	COG1131	(ABC) transporter
CH60_2586	COG0842	Transport permease protein
CH60_2587	COG0842	Transport permease protein
CH60_2590	COG1902	pentaerythritol trinitrate reductase activity
CH60_2594	COG2211	Major facilitator Superfamily
CH60_2595	COG1943	Transposase
CH60_2596	COG2211	Major facilitator Superfamily
CH60_2597	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CH60_2599	COG0583	DNA-binding transcription factor activity
CH60_2600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CH60_2604	COG1943	Transposase
CH60_2605	COG0670	Belongs to the BI1 family
CH60_2606	COG0314	molybdopterin synthase activity
CH60_2607	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH60_2609	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH60_2611	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH60_2615	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH60_2616	COG4628	conserved protein (DUF2132)
CH60_2617	COG0556	nucleotide-excision repair
CH60_2619	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH60_2620	COG2226	methyltransferase
CH60_2625	COG0561	phosphatase activity
CH60_2627	COG4149	molybdate abc transporter
CH60_2628	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH60_263	COG1454	alcohol dehydrogenase
CH60_2630	COG2005	Transcriptional regulator
CH60_2630	COG3585	molybdate ion transport
CH60_2631	COG1119	ATPase activity
CH60_2634	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH60_2635	COG1085	galactose-1-phosphate uridylyltransferase
CH60_2638	COG2017	converts alpha-aldose to the beta-anomer
CH60_2641	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH60_2643	COG1230	cation diffusion facilitator family transporter
CH60_2649	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH60_265	COG0629	single-stranded DNA binding
CH60_2650	COG2885	chlorophyll binding
CH60_2652	COG3064	Membrane
CH60_2652	COG3064	Membrane
CH60_2653	COG0848	biopolymer transport protein
CH60_2654	COG0811	peptide transport
CH60_2655	COG0824	Thioesterase
CH60_2656	COG3790	cyd operon protein YbgE
CH60_2657	COG4890	Cyd operon protein YbgT
CH60_2658	COG1294	oxidase, subunit
CH60_2659	COG1271	oxidase subunit
CH60_266	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH60_2660	COG1943	Transposase
CH60_2661	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH60_2663	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH60_2664	COG0567	Dehydrogenase, E1 component
CH60_2666	COG1053	succinate dehydrogenase
CH60_2667	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH60_2668	COG2009	succinate dehydrogenase
CH60_267	COG2315	Protein conserved in bacteria
CH60_2671	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH60_2672	COG0497	DNA recombination
CH60_2673	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH60_2675	COG2867	negative regulation of translational initiation
CH60_2677	COG1943	Transposase
CH60_2678	COG0582	viral genome integration into host DNA
CH60_268	COG1448	Aminotransferase
CH60_2688	COG3657	addiction module killer protein
CH60_269	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH60_2692	COG3447	MASE1 domain protein
CH60_2692	COG5001	Diguanylate cyclase
CH60_2692	COG5002	protein histidine kinase activity
CH60_2694	COG2226	methyltransferase
CH60_2696	COG1278	Cold shock
CH60_2699	COG1113	amino acid transport
CH60_270	COG0305	Participates in initiation and elongation during chromosome replication
CH60_2706	COG2207	Transcriptional regulator
CH60_2708	COG1132	(ABC) transporter
CH60_2714	COG2223	nitrite transmembrane transporter activity
CH60_2719	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH60_2724	COG3122	Protein conserved in bacteria
CH60_2728	COG0534	Mate efflux family protein
CH60_273	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH60_2732	COG4948	Mandelate Racemase Muconate Lactonizing
CH60_2734	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_2735	COG3011	Protein conserved in bacteria
CH60_2736	COG2271	Major facilitator Superfamily
CH60_2737	COG1470	cell adhesion involved in biofilm formation
CH60_2737	COG1388	LysM domain
CH60_274	COG0735	belongs to the Fur family
CH60_2741	COG2925	Exonuclease
CH60_2742	COG0531	amino acid
CH60_2744	COG0371	Dehydrogenase
CH60_2745	COG1129	ABC transporter
CH60_2750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH60_2752	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CH60_2754	COG0131	Imidazoleglycerol-phosphate dehydratase
CH60_2754	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH60_2755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CH60_2758	COG0140	phosphoribosyl-ATP diphosphatase activity
CH60_2758	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH60_276	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH60_2760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH60_2761	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH60_2764	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH60_2765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH60_2766	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH60_2767	COG1120	ATPase activity
CH60_2770	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CH60_2771	COG0076	glutamate decarboxylase activity
CH60_2772	COG4114	ferric iron reductase
CH60_2773	COG1253	flavin adenine dinucleotide binding
CH60_2774	COG2982	Protein involved in outer membrane biogenesis
CH60_2777	COG0489	protein tyrosine kinase activity
CH60_2779	COG1943	Transposase
CH60_2783	COG2814	Major facilitator Superfamily
CH60_2785	COG1346	cytolysis
CH60_2788	COG2949	membrane
CH60_2789	COG4211	Belongs to the binding-protein-dependent transport system permease family
CH60_2792	COG2311	Membrane
CH60_2794	COG0477	Major facilitator Superfamily
CH60_2795	COG0583	DNA-binding transcription factor activity
CH60_28	COG1295	ribonuclease BN
CH60_2801	COG1136	(ABC) transporter
CH60_2803	COG0303	'Molybdopterin
CH60_2805	COG3328	transposase activity
CH60_2807	COG0488	(ABC) transporter
CH60_2837	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH60_2838	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CH60_284	COG3121	Chaperone
CH60_2840	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_2841	COG1024	Enoyl-CoA hydratase
CH60_2843	COG3425	synthase
CH60_2844	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_2845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH60_2846	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH60_2848	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_2855	COG2920	part of a sulfur-relay system
CH60_2859	COG1832	CoA-binding protein
CH60_2860	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CH60_2862	COG0210	DNA helicase
CH60_2863	COG3304	Inner membrane component domain
CH60_2864	COG1289	transmembrane transporter activity
CH60_2865	COG3070	regulator of competence-specific genes
CH60_2867	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH60_2867	COG2885	chlorophyll binding
CH60_2868	COG1943	Transposase
CH60_2870	COG1061	Type III restriction enzyme res subunit
CH60_2871	COG1187	pseudouridine synthase activity
CH60_2872	COG2814	Major facilitator Superfamily
CH60_2874	COG4172	Belongs to the ABC transporter superfamily
CH60_2875	COG4239	(ABC) transporter, permease
CH60_2876	COG4174	ABC transporter (Permease)
CH60_2877	COG4166	transmembrane transport
CH60_2878	COG2200	EAL domain
CH60_2880	COG0791	NLP P60 protein
CH60_2881	COG0671	phosphoesterase, PA-phosphatase related
CH60_2882	COG0523	cobalamin synthesis protein
CH60_2884	COG2186	Transcriptional regulator
CH60_2885	COG0246	Mannitol dehydrogenase
CH60_2886	COG1312	Catalyzes the dehydration of D-mannonate
CH60_2890	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_2895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH60_2897	COG1129	ABC transporter
CH60_2898	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_2899	COG0494	nUDIX hydrolase
CH60_29	COG2982	Protein involved in outer membrane biogenesis
CH60_2901	COG1105	Belongs to the carbohydrate kinase PfkB family
CH60_2902	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH60_2902	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH60_2902	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH60_2903	COG3710	Transcriptional regulator
CH60_2906	COG3121	Chaperone
CH60_2907	COG3188	usher protein
CH60_2911	COG0435	Glutathione S-transferase
CH60_2912	COG2259	Doxx family
CH60_2914	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH60_2915	COG4575	ribosome binding
CH60_2918	COG0586	Pfam SNARE associated Golgi protein
CH60_2921	COG2271	Major facilitator Superfamily
CH60_2923	COG0246	Mannitol dehydrogenase
CH60_2924	COG2721	sulfolactate sulfo-lyase activity
CH60_2926	COG1943	Transposase
CH60_2929	COG0673	inositol 2-dehydrogenase activity
CH60_2930	COG1451	nucleotide metabolic process
CH60_2934	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH60_2934	COG1902	pentaerythritol trinitrate reductase activity
CH60_2935	COG3247	response to pH
CH60_2938	COG4245	von Willebrand factor, type A
CH60_2941	COG4245	von Willebrand factor, type A
CH60_2942	COG2831	hemolysin activation secretion protein
CH60_2943	COG3210	domain, Protein
CH60_2945	COG3210	domain, Protein
CH60_2947	COG3210	domain, Protein
CH60_2951	COG3842	ATPase activity
CH60_2952	COG3459	Glycosyltransferase 36 associated
CH60_2953	COG1609	Transcriptional regulator
CH60_2954	COG1653	transport
CH60_2956	COG0395	ABC-type sugar transport system, permease component
CH60_296	COG1358	cellular component organization or biogenesis
CH60_2960	COG1289	transmembrane transporter activity
CH60_2968	COG0251	oxidation-reduction process
CH60_2981	COG3328	transposase activity
CH60_2985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH60_2986	COG0358	DNA primase activity
CH60_2990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH60_2993	COG4991	sh3 domain protein
CH60_2994	COG3025	triphosphatase activity
CH60_2997	COG0531	amino acid
CH60_30	COG2134	cdp-diacylglycerol pyrophosphatase
CH60_3001	COG3384	dioxygenase
CH60_3002	COG0754	glutathionylspermidine amidase activity
CH60_3005	COG1538	Outer membrane efflux protein
CH60_3006	COG0494	nUDIX hydrolase
CH60_3007	COG3151	Protein conserved in bacteria
CH60_3008	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH60_3009	COG3150	esterase
CH60_301	COG3721	Heme iron utilization protein
CH60_3010	COG0187	DNA topoisomerase II activity
CH60_3011	COG0583	DNA-binding transcription factor activity
CH60_3012	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH60_3013	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH60_3014	COG0204	Acyl-transferase
CH60_3015	COG2132	Multicopper oxidase
CH60_3018	COG0656	L-ascorbic acid biosynthetic process
CH60_3019	COG1979	alcohol dehydrogenase
CH60_302	COG0702	epimerase
CH60_3020	COG2207	Transcriptional regulator
CH60_3021	COG0586	Pfam SNARE associated Golgi protein
CH60_3022	COG0626	cystathionine gamma-synthase activity
CH60_3023	COG0811	peptide transport
CH60_3025	COG0848	biopolymer transport protein
CH60_3035	COG4964	Belongs to the GSP D family
CH60_3036	COG4964	Belongs to the GSP D family
CH60_3039	COG1943	Transposase
CH60_304	COG4771	TonB-dependent receptor
CH60_3043	COG4592	Periplasmic binding protein
CH60_3048	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH60_3049	COG1684	flagellar biosynthetic protein fliR
CH60_305	COG3720	iron ion transport
CH60_3050	COG1987	bacterial-type flagellum assembly
CH60_3054	COG2204	response regulator
CH60_306	COG4558	Periplasmic binding protein
CH60_3063	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CH60_3064	COG1815	bacterial-type flagellum-dependent cell motility
CH60_3065	COG1558	bacterial-type flagellum-dependent cell motility
CH60_3066	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH60_3067	COG1749	Flagellar hook protein flgE
CH60_3068	COG4787	bacterial-type flagellum-dependent cell motility
CH60_3069	COG4786	Flagellar basal body rod
CH60_307	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH60_3070	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CH60_3071	COG1706	bacterial-type flagellum-dependent cell motility
CH60_3073	COG1256	bacterial-type flagellum assembly
CH60_3077	COG3710	Transcriptional regulator
CH60_3082	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH60_3084	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CH60_3089	COG1191	sigma factor activity
CH60_309	COG0626	cystathionine gamma-synthase activity
CH60_3090	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CH60_3095	COG3133	Outer membrane lipoprotein
CH60_3096	COG3133	Outer membrane lipoprotein
CH60_3099	COG2801	Transposase and inactivated derivatives
CH60_31	COG2200	EAL domain
CH60_310	COG0814	amino acid
CH60_311	COG0583	DNA-binding transcription factor activity
CH60_3110	COG1175	transmembrane transport
CH60_3111	COG3833	ABC-type maltose transport systems, permease component
CH60_3114	COG0527	aspartate kinase activity
CH60_3118	COG1414	Transcriptional regulator
CH60_312	COG0425	Belongs to the sulfur carrier protein TusA family
CH60_3120	COG2224	Isocitrate lyase
CH60_3121	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH60_3124	COG3328	transposase activity
CH60_313	COG2391	methyltransferase activity
CH60_3136	COG0151	Belongs to the GarS family
CH60_3139	COG3068	Protein conserved in bacteria
CH60_3140	COG1515	deoxyribonuclease V activity
CH60_3145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CH60_3147	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH60_3158	COG0250	Participates in transcription elongation, termination and antitermination
CH60_3159	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH60_3168	COG1943	Transposase
CH60_3169	COG3119	arylsulfatase activity
CH60_3170	COG1349	DNA-binding transcription factor activity
CH60_3172	COG2222	sugar isomerase
CH60_3173	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH60_3174	COG3715	PTS system
CH60_3175	COG3716	PTS system mannose fructose sorbose family IID component
CH60_3176	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH60_3178	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_3180	COG0641	radical SAM
CH60_3181	COG3119	arylsulfatase activity
CH60_3183	COG0191	fructose-bisphosphate aldolase activity
CH60_3187	COG2271	Major facilitator Superfamily
CH60_3191	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH60_3191	COG1263	PTS System
CH60_3192	COG1874	Beta-galactosidase
CH60_3193	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CH60_3194	COG3833	ABC-type maltose transport systems, permease component
CH60_3195	COG1175	transmembrane transport
CH60_3196	COG2182	Extracellular solute-binding protein
CH60_3198	COG1129	ABC transporter
CH60_3199	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_32	COG1942	4-Oxalocrotonate Tautomerase
CH60_3200	COG1879	ABC-type sugar transport system periplasmic component
CH60_3202	COG0791	NLP P60 protein
CH60_3203	COG1695	Transcriptional regulator
CH60_3220	COG2944	sequence-specific DNA binding
CH60_3225	COG0582	viral genome integration into host DNA
CH60_3229	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH60_3230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH60_3231	COG4974	Belongs to the 'phage' integrase family
CH60_3232	COG0716	FMN binding
CH60_3233	COG4452	Inner membrane protein CreD
CH60_3234	COG2205	protein histidine kinase activity
CH60_3235	COG0745	RESPONSE REGULATOR receiver
CH60_3236	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CH60_3239	COG1272	protein, Hemolysin III
CH60_3241	COG5295	Hep Hag repeat protein
CH60_3247	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH60_3248	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH60_3249	COG0006	proline dipeptidase activity
CH60_3252	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH60_3253	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH60_3254	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH60_3259	COG0191	fructose-bisphosphate aldolase activity
CH60_3262	COG1943	Transposase
CH60_3263	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH60_3264	COG0501	Belongs to the peptidase M48B family
CH60_3266	COG1166	arginine decarboxylase activity
CH60_3270	COG2356	endonuclease I
CH60_3271	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH60_3272	COG0189	ligase activity
CH60_3275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH60_3277	COG2805	Type II/IV secretion system protein
CH60_3278	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH60_3279	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH60_3280	COG0762	integral membrane protein
CH60_3282	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH60_3283	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH60_3285	COG3328	transposase activity
CH60_3286	COG3328	transposase activity
CH60_3287	COG3064	Membrane
CH60_3287	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CH60_3287	COG1073	alpha beta
CH60_3290	COG2066	Belongs to the glutaminase family
CH60_3291	COG3171	Protein conserved in bacteria
CH60_3293	COG1194	a g-specific adenine glycosylase
CH60_3297	COG4774	siderophore transport
CH60_3298	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_3299	COG1129	ABC transporter
CH60_33	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH60_3300	COG1879	ABC-type sugar transport system periplasmic component
CH60_3301	COG1982	Orn Lys Arg decarboxylase major
CH60_3306	COG1662	PFAM IS1 transposase
CH60_3329	COG2771	luxR family
CH60_3330	COG3916	Acyl-homoserine-lactone synthase
CH60_3340	COG2211	Major facilitator Superfamily
CH60_3343	COG0471	metal ion transport
CH60_3346	COG3209	COG3209 Rhs family protein
CH60_3348	COG3501	Rhs element vgr protein
CH60_335	COG1301	dicarboxylic acid transport
CH60_3352	COG2610	gluconate transmembrane transporter activity
CH60_3356	COG1132	(ABC) transporter
CH60_3362	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH60_3362	COG2226	methyltransferase
CH60_3362	COG3433	isochorismatase activity
CH60_3363	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH60_3364	COG3433	isochorismatase activity
CH60_3364	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH60_3364	COG2226	methyltransferase
CH60_3365	COG4771	TonB-dependent receptor
CH60_3366	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH60_337	COG3162	membrane
CH60_3370	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH60_3371	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CH60_3379	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH60_3380	COG5001	Diguanylate cyclase
CH60_3380	COG3300	MHYT domain
CH60_3381	COG2801	Transposase and inactivated derivatives
CH60_3396	COG3501	Rhs element vgr protein
CH60_3399	COG3209	COG3209 Rhs family protein
CH60_34	COG0612	Peptidase, M16
CH60_3405	COG3501	Rhs element vgr protein
CH60_3407	COG3209	COG3209 Rhs family protein
CH60_3410	COG0673	inositol 2-dehydrogenase activity
CH60_3411	COG1917	Cupin 2, conserved barrel domain protein
CH60_3411	COG2207	Transcriptional regulator
CH60_3412	COG1869	D-ribose catabolic process
CH60_3413	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH60_3415	COG0431	NADPH-dependent FMN reductase
CH60_3419	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH60_3421	COG3077	Addiction module antitoxin, RelB DinJ family
CH60_3422	COG2252	PERMEase
CH60_3423	COG0025	NhaP-type Na H and K H
CH60_3425	COG1560	Kdo2-lipid A biosynthetic process
CH60_3427	COG1129	ABC transporter
CH60_3428	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_343	COG0077	Prephenate dehydratase
CH60_343	COG1605	Chorismate mutase
CH60_3430	COG1069	ribulokinase activity
CH60_3432	COG0625	glutathione transferase activity
CH60_3435	COG1943	Transposase
CH60_3436	COG1278	Cold shock
CH60_3437	COG1278	Cold shock
CH60_3438	COG3133	Outer membrane lipoprotein
CH60_3439	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH60_344	COG1605	Chorismate mutase
CH60_344	COG0287	Prephenate dehydrogenase
CH60_3441	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH60_3445	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH60_3446	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH60_3448	COG4145	pantothenate transmembrane transporter activity
CH60_3449	COG3924	membrane
CH60_345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH60_3451	COG0439	Biotin carboxylase
CH60_3452	COG0511	ligase activity, forming carbon-carbon bonds
CH60_3455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CH60_3456	COG0604	alcohol dehydrogenase
CH60_3457	COG2200	EAL domain
CH60_3457	COG2199	diguanylate cyclase activity
CH60_3458	COG1077	Cell shape determining protein MreB Mrl
CH60_3459	COG1792	Involved in formation and maintenance of cell shape
CH60_346	COG3279	Response regulator of the LytR AlgR family
CH60_3460	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH60_3462	COG1530	ribonuclease E activity
CH60_3463	COG3164	Protein of unknown function
CH60_3464	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH60_3465	COG0312	modulator of DNA gyrase
CH60_347	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH60_3475	COG0583	DNA-binding transcription factor activity
CH60_3479	COG1012	belongs to the aldehyde dehydrogenase family
CH60_348	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH60_3482	COG2732	(Barnase) inhibitor
CH60_3484	COG0312	modulator of DNA gyrase
CH60_3486	COG3783	Cytochrome b(562)
CH60_3487	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH60_3488	COG0366	Alpha amylase catalytic
CH60_3489	COG1263	PTS System
CH60_3489	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH60_349	COG3137	Salt-induced outer membrane protein
CH60_3490	COG1609	Transcriptional regulator
CH60_3495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH60_3497	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH60_3499	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH60_3500	COG1137	ATPase activity
CH60_3501	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH60_3502	COG3117	lipopolysaccharide transmembrane transporter activity
CH60_3503	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH60_3504	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH60_3504	COG0517	IMP dehydrogenase activity
CH60_3505	COG0530	calcium, potassium:sodium antiporter activity
CH60_3506	COG1127	ABC transporter
CH60_3507	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH60_3508	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH60_3509	COG2854	intermembrane phospholipid transfer
CH60_3510	COG3113	response to antibiotic
CH60_3511	COG5007	Belongs to the BolA IbaG family
CH60_3513	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH60_3514	COG1943	Transposase
CH60_3516	COG0473	3-isopropylmalate dehydrogenase activity
CH60_3523	COG2814	Major facilitator Superfamily
CH60_3526	COG4143	(ABC) transporter
CH60_3527	COG1178	ABC-type Fe3 transport system permease component
CH60_3529	COG0586	Pfam SNARE associated Golgi protein
CH60_3530	COG0417	DNA replication proofreading
CH60_3534	COG2885	chlorophyll binding
CH60_3534	COG3047	cAMP biosynthetic process
CH60_354	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH60_355	COG4137	Cytochrome C assembly protein
CH60_3552	COG0564	pseudouridine synthase activity
CH60_3553	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH60_3555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH60_3556	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CH60_356	COG4536	flavin adenine dinucleotide binding
CH60_3561	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH60_3563	COG2966	Psort location CytoplasmicMembrane, score
CH60_3564	COG1280	lysine exporter protein (LysE YggA)
CH60_3565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH60_3566	COG0505	Belongs to the CarA family
CH60_3568	COG1943	Transposase
CH60_3570	COG1047	Peptidyl-prolyl cis-trans
CH60_3573	COG0196	riboflavin kinase activity
CH60_3575	COG0583	DNA-binding transcription factor activity
CH60_3579	COG1584	GPR1 FUN34 yaaH family protein
CH60_358	COG2918	glutathione biosynthetic process
CH60_3582	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH60_359	COG1238	metal cluster binding
CH60_3592	COG0745	RESPONSE REGULATOR receiver
CH60_3593	COG3045	CreA protein
CH60_3596	COG2207	Transcriptional regulator
CH60_3596	COG3708	Transcriptional regulator
CH60_3597	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH60_3599	COG0741	lytic transglycosylase activity
CH60_360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH60_3602	COG2199	diguanylate cyclase activity
CH60_3603	COG2885	chlorophyll binding
CH60_3604	COG0488	(ABC) transporter
CH60_3608	COG0560	Phosphoserine phosphatase
CH60_3609	COG3726	membrane protein affecting hemolysin expression
CH60_3613	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH60_3614	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH60_3615	COG0084	hydrolase, TatD family'
CH60_3616	COG4667	esterase of the alpha-beta hydrolase superfamily
CH60_3618	COG2823	Periplasmic or secreted lipoprotein
CH60_3620	COG0456	acetyltransferase
CH60_3621	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH60_3625	COG3706	GGDEF domain
CH60_3628	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH60_3629	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH60_3632	COG0859	PFAM glycosyl transferase family 9
CH60_3634	COG2390	Transcriptional regulator
CH60_3642	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH60_3642	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH60_3642	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH60_3643	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH60_3644	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH60_3645	COG2207	Transcriptional regulator
CH60_3646	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH60_3648	COG4269	membrane
CH60_365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH60_3657	COG2963	transposase activity
CH60_3658	COG2801	Transposase and inactivated derivatives
CH60_366	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH60_3660	COG1401	restriction endodeoxyribonuclease activity
CH60_3665	COG0494	nUDIX hydrolase
CH60_3670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH60_3671	COG0849	cell division
CH60_3672	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH60_3676	COG0772	Belongs to the SEDS family
CH60_3679	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH60_3680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH60_3681	COG0768	penicillin binding
CH60_3682	COG3116	cell division
CH60_3686	COG1609	Transcriptional regulator
CH60_3687	COG1943	Transposase
CH60_3689	COG0028	Belongs to the TPP enzyme family
CH60_3690	COG1022	Amp-dependent synthetase and ligase
CH60_3693	COG1943	Transposase
CH60_3694	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH60_3695	COG3105	Protein conserved in bacteria
CH60_3696	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH60_3699	COG0625	glutathione transferase activity
CH60_3700	COG2969	positive regulation of protein catabolic process
CH60_3702	COG0493	'glutamate synthase
CH60_3703	COG0070	glutamate synthase
CH60_3703	COG0069	glutamate synthase activity
CH60_3703	COG0067	glutamate synthase
CH60_3704	COG1242	4 iron, 4 sulfur cluster binding
CH60_3705	COG5002	protein histidine kinase activity
CH60_3705	COG2198	Histidine kinase
CH60_3705	COG0784	Response regulator, receiver
CH60_3706	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH60_3708	COG2823	Periplasmic or secreted lipoprotein
CH60_3712	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH60_3713	COG1741	Belongs to the pirin family
CH60_3714	COG0583	DNA-binding transcription factor activity
CH60_3715	COG0435	Glutathione S-transferase
CH60_3720	COG0805	protein transport
CH60_3722	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH60_3726	COG1322	Protein conserved in bacteria
CH60_3727	COG0586	Pfam SNARE associated Golgi protein
CH60_3728	COG1966	Carbon starvation protein
CH60_373	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH60_3730	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CH60_3731	COG0412	Dienelactone hydrolase
CH60_3734	COG0583	DNA-binding transcription factor activity
CH60_3735	COG0679	Auxin Efflux Carrier
CH60_3736	COG0584	glycerophosphoryl diester phosphodiesterase
CH60_374	COG3958	Transketolase
CH60_3748	COG0410	ABC transporter
CH60_3749	COG0411	ABC transporter
CH60_375	COG3959	Transketolase, thiamine diphosphate binding domain
CH60_3750	COG4177	L-phenylalanine transmembrane transporter activity
CH60_3751	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH60_3752	COG0683	leucine binding
CH60_3754	COG1943	Transposase
CH60_3756	COG2177	Part of the ABC transporter FtsEX involved in
CH60_3757	COG2884	Cell division ATP-binding protein ftsE
CH60_3758	COG0552	protein localization to endoplasmic reticulum
CH60_3758	COG0552	protein localization to endoplasmic reticulum
CH60_3759	COG0742	ribosomal rna small subunit methyltransferase
CH60_376	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_3760	COG3776	membrane
CH60_3763	COG3714	YhhN family
CH60_3766	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH60_3768	COG0247	lactate metabolic process
CH60_377	COG1129	ABC transporter
CH60_3770	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH60_3771	COG0584	glycerophosphoryl diester phosphodiesterase
CH60_3773	COG0561	phosphatase activity
CH60_3774	COG2267	carboxylic ester hydrolase activity
CH60_3775	COG1280	lysine exporter protein (LysE YggA)
CH60_3776	COG1280	lysine exporter protein (LysE YggA)
CH60_3777	COG0514	ATP-dependent DNA helicase (RecQ)
CH60_3778	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CH60_3779	COG2050	protein possibly involved in aromatic compounds catabolism
CH60_3781	COG0598	Magnesium transport protein CorA
CH60_3782	COG5564	TIM-barrel signal transduction protein
CH60_3783	COG5441	Belongs to the UPF0261 family
CH60_3785	COG0210	DNA helicase
CH60_3786	COG1011	Hydrolase
CH60_3787	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH60_3788	COG3159	Protein conserved in bacteria
CH60_3790	COG5567	small periplasmic lipoprotein
CH60_3792	COG3072	Adenylate cyclase
CH60_3794	COG1587	Uroporphyrinogen-III synthase
CH60_3795	COG2959	enzyme of heme biosynthesis
CH60_3796	COG3071	HemY protein
CH60_3797	COG1943	Transposase
CH60_3803	COG1113	amino acid transport
CH60_3807	COG2244	polysaccharide biosynthetic process
CH60_3808	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH60_3809	COG0456	acetyltransferase
CH60_381	COG3783	Cytochrome b(562)
CH60_3810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH60_3811	COG1088	dTDP-glucose 4,6-dehydratase activity
CH60_3812	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH60_3813	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH60_3814	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH60_3815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH60_3816	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH60_3817	COG3118	belongs to the thioredoxin family
CH60_382	COG3038	cytochrome b561
CH60_3821	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH60_3824	COG3121	Chaperone
CH60_3827	COG3121	Chaperone
CH60_383	COG3381	protein complex oligomerization
CH60_3834	COG0583	DNA-binding transcription factor activity
CH60_384	COG3302	dmso reductase anchor subunit
CH60_3842	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH60_3843	COG3978	acetolactate synthase activity
CH60_3846	COG3085	chromosome segregation
CH60_3847	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_3849	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_385	COG0437	4 iron, 4 sulfur cluster binding
CH60_3850	COG1129	ABC transporter
CH60_3851	COG1879	ABC-type sugar transport system periplasmic component
CH60_386	COG0243	molybdopterin cofactor binding
CH60_3866	COG0678	peroxiredoxin activity
CH60_3866	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH60_3867	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH60_387	COG0235	Class ii aldolase
CH60_3872	COG1629	transport
CH60_3876	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CH60_388	COG1349	DNA-binding transcription factor activity
CH60_3880	COG2801	Transposase and inactivated derivatives
CH60_3891	COG2864	formate dehydrogenase
CH60_3892	COG0437	4 iron, 4 sulfur cluster binding
CH60_3893	COG0243	molybdopterin cofactor binding
CH60_3893	COG3383	formate dehydrogenase (NAD+) activity
CH60_3894	COG0243	molybdopterin cofactor binding
CH60_3894	COG3383	formate dehydrogenase (NAD+) activity
CH60_3896	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH60_39	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH60_390	COG1129	ABC transporter
CH60_3903	COG3722	fumarate hydratase activity
CH60_3905	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH60_3905	COG2213	PTS system mannitol-specific
CH60_391	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_3910	COG2818	Glycosylase
CH60_3912	COG2885	chlorophyll binding
CH60_3915	COG0366	Alpha amylase catalytic
CH60_3917	COG3977	Valine--pyruvate aminotransferase
CH60_392	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_3921	COG5645	(Lipo)protein
CH60_3922	COG0823	Involved in the tonB-independent uptake of proteins
CH60_3923	COG0823	Involved in the tonB-independent uptake of proteins
CH60_3924	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH60_3925	COG2423	ornithine cyclodeaminase activity
CH60_3928	COG2801	Transposase and inactivated derivatives
CH60_3929	COG0561	phosphatase activity
CH60_393	COG3623	hexulose-6-phosphate isomerase
CH60_3930	COG0187	DNA topoisomerase II activity
CH60_3931	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH60_3932	COG0592	DNA-directed DNA polymerase activity
CH60_3935	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH60_3938	COG0706	membrane insertase activity
CH60_394	COG1070	Carbohydrate kinase
CH60_3943	COG2252	PERMEase
CH60_3944	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH60_3945	COG0765	amino acid transport
CH60_3946	COG0765	amino acid transport
CH60_3947	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH60_3949	COG0704	Plays a role in the regulation of phosphate uptake
CH60_395	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH60_395	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH60_3951	COG0581	inorganic phosphate transmembrane transporter activity
CH60_3952	COG0573	inorganic phosphate transmembrane transporter activity
CH60_3953	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH60_3954	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CH60_3964	COG3312	ion transport
CH60_3967	COG0716	FMN binding
CH60_3968	COG1522	sequence-specific DNA binding
CH60_397	COG0024	Methionine aminopeptidase
CH60_3974	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH60_3975	COG0477	Major facilitator Superfamily
CH60_3977	COG2186	Transcriptional regulator
CH60_3982	COG3328	transposase activity
CH60_3983	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH60_3985	COG3084	Protein conserved in bacteria
CH60_3986	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH60_3987	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH60_3988	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH60_3988	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH60_399	COG4771	TonB-dependent receptor
CH60_3991	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH60_3993	COG3852	Histidine kinase
CH60_3994	COG0174	glutamine synthetase
CH60_3996	COG1011	Hydrolase
CH60_3997	COG1295	ribonuclease BN
CH60_4	COG0191	fructose-bisphosphate aldolase activity
CH60_40	COG2200	EAL domain
CH60_40	COG2199	diguanylate cyclase activity
CH60_4001	COG0456	acetyltransferase
CH60_4002	COG2982	Protein involved in outer membrane biogenesis
CH60_4003	COG2233	PERMEase
CH60_4004	COG0786	glutamate:sodium symporter activity
CH60_4005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH60_4006	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH60_4007	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH60_401	COG3328	transposase activity
CH60_4010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH60_4011	COG2860	membrane
CH60_4012	COG1561	YicC-like family, N-terminal region
CH60_4017	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH60_402	COG3328	transposase activity
CH60_4020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH60_4024	COG1519	Transferase
CH60_4025	COG0859	PFAM glycosyl transferase family 9
CH60_4026	COG0859	PFAM glycosyl transferase family 9
CH60_4028	COG0156	8-amino-7-oxononanoate synthase activity
CH60_403	COG1858	cytochrome C peroxidase
CH60_4030	COG2861	carbohydrate metabolic process
CH60_4031	COG2861	carbohydrate metabolic process
CH60_4032	COG4942	peptidase
CH60_4034	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH60_4035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH60_4038	COG1045	serine acetyltransferase
CH60_4039	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH60_404	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH60_4040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH60_4040	COG2169	Transcriptional regulator
CH60_4041	COG2205	protein histidine kinase activity
CH60_4042	COG0745	RESPONSE REGULATOR receiver
CH60_4043	COG3678	ATP-independent chaperone mediated protein folding
CH60_4048	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH60_4050	COG0471	metal ion transport
CH60_4051	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CH60_4052	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CH60_4053	COG0583	DNA-binding transcription factor activity
CH60_4056	COG3152	Membrane
CH60_4058	COG1494	fructose-1,6-bisphosphatase
CH60_4059	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH60_4060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH60_4062	COG1943	Transposase
CH60_4068	COG1575	Belongs to the MenA family. Type 1 subfamily
CH60_4071	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH60_4072	COG1609	Transcriptional regulator
CH60_4074	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH60_4076	COG4682	membrane
CH60_4078	COG0626	cystathionine gamma-synthase activity
CH60_4079	COG0527	aspartate kinase activity
CH60_4079	COG0460	homoserine dehydrogenase
CH60_408	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH60_4081	COG2801	Transposase and inactivated derivatives
CH60_4083	COG3274	enterobacterial common antigen metabolic process
CH60_4085	COG3188	usher protein
CH60_4086	COG3188	usher protein
CH60_4087	COG3121	Chaperone
CH60_4089	COG1070	Carbohydrate kinase
CH60_4091	COG4213	ABC transporter substrate-binding protein
CH60_4093	COG4214	carbohydrate transport
CH60_4094	COG2207	Transcriptional regulator
CH60_4094	COG1609	Transcriptional regulator
CH60_4096	COG0582	viral genome integration into host DNA
CH60_41	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CH60_4103	COG4604	ABC transporter, ATP-binding protein
CH60_4105	COG4605	iron ion homeostasis
CH60_4107	COG4607	ABC-type enterochelin transport system periplasmic component
CH60_411	COG2376	Dihydroxyacetone kinase
CH60_4110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH60_4113	COG2986	histidine ammonia-lyase
CH60_4114	COG1113	amino acid transport
CH60_412	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_4125	COG1739	Uncharacterized protein family UPF0029
CH60_4126	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH60_4127	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CH60_413	COG1063	alcohol dehydrogenase
CH60_4132	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CH60_4138	COG2801	Transposase and inactivated derivatives
CH60_414	COG0698	ribose 5-phosphate isomerase
CH60_4141	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH60_4142	COG0058	SHG alpha-glucan phosphorylase activity
CH60_4144	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH60_4147	COG3275	phosphorelay sensor kinase activity
CH60_415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH60_4153	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH60_4154	COG2095	MarC family integral membrane protein
CH60_4158	COG3265	gluconokinase activity
CH60_4159	COG2610	gluconate transmembrane transporter activity
CH60_416	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH60_4160	COG1609	Transcriptional regulator
CH60_4164	COG3941	tape measure
CH60_417	COG1388	LysM domain
CH60_417	COG4942	peptidase
CH60_4183	COG1475	DNA binding
CH60_4184	COG1475	DNA binding
CH60_4185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH60_4194	COG1943	Transposase
CH60_4196	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH60_4197	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH60_42	COG4608	Belongs to the ABC transporter superfamily
CH60_4203	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH60_4213	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH60_4215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH60_422	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CH60_4244	COG1475	DNA binding
CH60_425	COG0529	Catalyzes the synthesis of activated sulfate
CH60_4262	COG3328	transposase activity
CH60_4267	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CH60_4269	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH60_4269	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH60_4277	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH60_4278	COG4790	Type iii secretion
CH60_4279	COG4794	Type iii secretion
CH60_4280	COG4791	protein targeting
CH60_4281	COG4792	protein secretion
CH60_4283	COG2207	Transcriptional regulator
CH60_4292	COG4669	(LipO)protein
CH60_4294	COG1317	bacterial-type flagellum organization
CH60_4295	COG5599	Phosphatase
CH60_4296	COG2963	transposase activity
CH60_4297	COG2801	Transposase and inactivated derivatives
CH60_43	COG0444	Belongs to the ABC transporter superfamily
CH60_4300	COG2801	Transposase and inactivated derivatives
CH60_4302	COG0515	serine threonine protein kinase
CH60_4319	COG2801	Transposase and inactivated derivatives
CH60_4324	COG2801	Transposase and inactivated derivatives
CH60_4333	COG2801	Transposase and inactivated derivatives
CH60_4335	COG5599	Phosphatase
CH60_4337	COG3609	addiction module antidote protein, CC2985 family
CH60_4339	COG1475	DNA binding
CH60_4340	COG1192	Involved in chromosome partitioning
CH60_4343	COG2801	Transposase and inactivated derivatives
CH60_4347	COG3177	Filamentation induced by cAMP protein fic
CH60_4352	COG4886	Leucine-rich repeat (LRR) protein
CH60_4352	COG4886	Leucine-rich repeat (LRR) protein
CH60_4357	COG0457	Tetratricopeptide repeat
CH60_436	COG0720	synthase
CH60_4361	COG4789	Type iii secretion
CH60_4368	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CH60_437	COG0602	queuosine metabolic process
CH60_44	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH60_441	COG3956	TIGRFAM MazG family protein
CH60_442	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH60_443	COG4999	Histidine kinase
CH60_443	COG3850	Histidine kinase
CH60_443	COG2205	protein histidine kinase activity
CH60_443	COG3437	response regulator, receiver
CH60_444	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH60_446	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH60_448	COG2860	membrane
CH60_45	COG0601	transmembrane transport
CH60_452	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH60_453	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH60_454	COG1120	ATPase activity
CH60_455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH60_456	COG1643	Atp-dependent helicase
CH60_457	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CH60_459	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH60_46	COG0747	negative chemotaxis
CH60_460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH60_461	COG0617	tRNA 3'-terminal CCA addition
CH60_462	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH60_466	COG0726	polysaccharide deacetylase
CH60_468	COG0842	Transport permease protein
CH60_469	COG1131	(ABC) transporter
CH60_470	COG0288	reversible hydration of carbon dioxide
CH60_471	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH60_472	COG2132	Multicopper oxidase
CH60_476	COG0697	spore germination
CH60_478	COG1049	propionate catabolic process, 2-methylcitrate cycle
CH60_479	COG1943	Transposase
CH60_48	COG2831	hemolysin activation secretion protein
CH60_480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH60_481	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH60_482	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH60_483	COG2186	Transcriptional regulator
CH60_484	COG1113	amino acid transport
CH60_485	COG3725	Membrane protein required for beta-lactamase induction
CH60_486	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH60_488	COG4969	Belongs to the N-Me-Phe pilin family
CH60_489	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH60_490	COG1459	type II secretion system
CH60_492	COG0237	dephospho-CoA kinase activity
CH60_495	COG1943	Transposase
CH60_498	COG1943	Transposase
CH60_500	COG3061	Opacity-associated protein A
CH60_501	COG0545	Peptidyl-prolyl cis-trans isomerase
CH60_503	COG0737	Belongs to the 5'-nucleotidase family
CH60_505	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH60_507	COG1253	flavin adenine dinucleotide binding
CH60_509	COG0729	surface antigen
CH60_51	COG2271	Major facilitator Superfamily
CH60_510	COG2911	Protein conserved in bacteria
CH60_511	COG2105	PFAM AIG2 family protein
CH60_512	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH60_514	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH60_518	COG3423	Transcriptional regulator
CH60_52	COG3851	Histidine kinase
CH60_520	COG0142	geranyltranstransferase activity
CH60_523	COG0697	spore germination
CH60_525	COG0642	Histidine kinase
CH60_526	COG0745	RESPONSE REGULATOR receiver
CH60_527	COG2027	D-alanyl-D-alanine carboxypeptidase
CH60_528	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH60_529	COG1534	Rna-binding protein
CH60_53	COG2197	response regulator
CH60_531	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CH60_532	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH60_534	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH60_538	COG0195	Participates in both transcription termination and antitermination
CH60_54	COG2194	sulfuric ester hydrolase activity
CH60_544	COG2801	Transposase and inactivated derivatives
CH60_547	COG0513	Belongs to the DEAD box helicase family
CH60_550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH60_553	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH60_558	COG3153	acetyltransferase
CH60_562	COG1653	transport
CH60_564	COG0395	ABC-type sugar transport system, permease component
CH60_569	COG0702	epimerase
CH60_570	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CH60_571	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CH60_572	COG3454	Phosphonate metabolism
CH60_573	COG4778	phosphonate C-P lyase system protein PhnL
CH60_574	COG4107	phosphonate C-P lyase system protein PhnK
CH60_575	COG3627	carbon phosphorus lyase activity
CH60_576	COG3626	phosphonate metabolism
CH60_577	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CH60_578	COG3624	Phosphonate C-P lyase system protein PhnG
CH60_579	COG2188	Transcriptional regulator
CH60_583	COG4608	Belongs to the ABC transporter superfamily
CH60_584	COG0444	Belongs to the ABC transporter superfamily
CH60_585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH60_586	COG0601	transmembrane transport
CH60_589	COG2731	YhcH YjgK YiaL family protein
CH60_590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CH60_591	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH60_593	COG0525	valine-tRNA ligase activity
CH60_594	COG2927	DNA polymerase III (CHI subunit)
CH60_596	COG0795	lipopolysaccharide-transporting ATPase activity
CH60_597	COG0795	lipopolysaccharide-transporting ATPase activity
CH60_599	COG0582	viral genome integration into host DNA
CH60_6	COG1879	ABC-type sugar transport system periplasmic component
CH60_60	COG1349	DNA-binding transcription factor activity
CH60_604	COG1943	Transposase
CH60_605	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH60_606	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH60_607	COG0564	pseudouridine synthase activity
CH60_609	COG0542	response to heat
CH60_616	COG5544	Lipoprotein
CH60_617	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH60_618	COG1042	CoA-binding domain protein
CH60_618	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH60_618	COG0045	succinate-CoA ligase (ADP-forming) activity
CH60_620	COG3118	belongs to the thioredoxin family
CH60_621	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH60_622	COG2814	Major facilitator Superfamily
CH60_623	COG1566	PFAM secretion protein HlyD family protein
CH60_624	COG1846	Transcriptional regulator
CH60_626	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH60_627	COG2814	Major facilitator Superfamily
CH60_636	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH60_64	COG0058	SHG alpha-glucan phosphorylase activity
CH60_644	COG0395	ABC-type sugar transport system, permease component
CH60_645	COG1175	transmembrane transport
CH60_647	COG0673	inositol 2-dehydrogenase activity
CH60_654	COG3328	transposase activity
CH60_655	COG3328	transposase activity
CH60_67	COG1640	4-alpha-glucanotransferase
CH60_679	COG2197	response regulator
CH60_681	COG3136	membrane protein required for alginate biosynthesis
CH60_685	COG1113	amino acid transport
CH60_688	COG2837	iron assimilation
CH60_693	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH60_693	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH60_693	COG0506	proline dehydrogenase activity
CH60_699	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH60_7	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_701	COG1191	sigma factor activity
CH60_707	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CH60_708	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH60_709	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CH60_712	COG1677	Flagellar hook-basal body complex protein FliE
CH60_714	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH60_716	COG1157	protein secretion by the type III secretion system
CH60_717	COG2882	bacterial-type flagellum organization
CH60_719	COG1580	Controls the rotational direction of flagella during chemotaxis
CH60_724	COG1987	bacterial-type flagellum assembly
CH60_728	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH60_729	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_730	COG1129	ABC transporter
CH60_732	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH60_733	COG1028	Short-chain dehydrogenase reductase Sdr
CH60_733	COG3347	Dehydrogenase
CH60_734	COG2390	Transcriptional regulator
CH60_736	COG1256	bacterial-type flagellum assembly
CH60_74	COG1918	ferrous iron import across plasma membrane
CH60_740	COG4786	Flagellar basal body rod
CH60_742	COG1749	Flagellar hook protein flgE
CH60_743	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH60_744	COG1558	bacterial-type flagellum-dependent cell motility
CH60_745	COG1815	bacterial-type flagellum-dependent cell motility
CH60_747	COG2747	anti-sigma28 factor FlgM
CH60_748	COG3418	PFAM FlgN family protein
CH60_75	COG2183	response to ionizing radiation
CH60_750	COG1943	Transposase
CH60_753	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH60_754	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH60_759	COG2372	response to copper ion
CH60_76	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH60_760	COG1528	Iron-storage protein
CH60_763	COG1770	oligopeptidase
CH60_766	COG3141	response to X-ray
CH60_767	COG0513	Belongs to the DEAD box helicase family
CH60_77	COG0745	RESPONSE REGULATOR receiver
CH60_772	COG1760	l-serine dehydratase
CH60_773	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CH60_774	COG2368	4-hydroxyphenylacetate
CH60_778	COG3971	2-oxopent-4-enoate hydratase activity
CH60_780	COG3384	dioxygenase
CH60_781	COG1012	belongs to the aldehyde dehydrogenase family
CH60_784	COG1846	Transcriptional regulator
CH60_785	COG1253	flavin adenine dinucleotide binding
CH60_786	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH60_786	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH60_787	COG3715	PTS system
CH60_788	COG3716	PTS system mannose fructose sorbose family IID component
CH60_796	COG0671	phosphoesterase, PA-phosphatase related
CH60_796	COG2453	phosphatase
CH60_797	COG2267	carboxylic ester hydrolase activity
CH60_799	COG4589	Belongs to the CDS family
CH60_800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH60_807	COG2501	S4 domain
CH60_808	COG1943	Transposase
CH60_81	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH60_811	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH60_813	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH60_814	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH60_815	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH60_816	COG4181	ATPase activity
CH60_817	COG2755	lipolytic protein G-D-S-L family
CH60_818	COG0300	oxidoreductase activity
CH60_819	COG3118	belongs to the thioredoxin family
CH60_82	COG1011	Hydrolase
CH60_820	COG0330	HflC and HflK could
CH60_821	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH60_822	COG0789	Transcriptional regulator
CH60_823	COG2217	Heavy metal translocating P-type atpase
CH60_824	COG3735	TraB family
CH60_825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH60_828	COG0737	Belongs to the 5'-nucleotidase family
CH60_829	COG0737	Belongs to the 5'-nucleotidase family
CH60_830	COG0737	Belongs to the 5'-nucleotidase family
CH60_831	COG2223	nitrite transmembrane transporter activity
CH60_832	COG4651	solute:proton antiporter activity
CH60_832	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH60_833	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH60_834	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH60_838	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH60_839	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH60_840	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH60_85	COG0494	nUDIX hydrolase
CH60_850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH60_854	COG0543	2 iron, 2 sulfur cluster binding
CH60_854	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH60_86	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH60_860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CH60_862	COG2832	Protein of unknown function (DUF454)
CH60_864	COG3264	Mechanosensitive ion channel
CH60_864	COG1196	nuclear chromosome segregation
CH60_865	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH60_866	COG1309	transcriptional regulator
CH60_867	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH60_868	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH60_870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH60_874	COG3695	enzyme binding
CH60_875	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH60_876	COG1946	Acyl-CoA thioesterase
CH60_877	COG0004	ammonium transporteR
CH60_878	COG0347	Belongs to the P(II) protein family
CH60_879	COG1132	(ABC) transporter
CH60_880	COG1132	(ABC) transporter
CH60_881	COG1522	sequence-specific DNA binding
CH60_884	COG4533	DNA binding
CH60_886	COG0824	Thioesterase
CH60_887	COG1555	photosystem II stabilization
CH60_888	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH60_889	COG0776	regulation of translation
CH60_890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH60_895	COG0271	Belongs to the BolA IbaG family
CH60_896	COG3056	Lipoprotein
CH60_897	COG2223	nitrite transmembrane transporter activity
CH60_899	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH60_900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH60_901	COG1845	cytochrome c oxidase, subunit III
CH60_902	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH60_904	COG2814	Major facilitator Superfamily
CH60_906	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH60_907	COG0693	protein deglycase activity
CH60_91	COG4796	Type ii and iii secretion system protein
CH60_910	COG0142	geranyltranstransferase activity
CH60_912	COG1943	Transposase
CH60_913	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH60_914	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH60_917	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH60_917	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH60_921	COG1943	Transposase
CH60_922	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH60_923	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH60_924	COG1862	Preprotein translocase
CH60_926	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CH60_927	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH60_928	COG0450	alkyl hydroperoxide reductase
CH60_932	COG0366	Alpha amylase catalytic
CH60_934	COG1114	Component of the transport system for branched-chain amino acids
CH60_936	COG5002	protein histidine kinase activity
CH60_937	COG0745	RESPONSE REGULATOR receiver
CH60_938	COG0420	3'-5' exonuclease activity
CH60_939	COG0419	ATPase involved in DNA repair
CH60_940	COG1940	carbohydrate kinase activity
CH60_945	COG2226	methyltransferase
CH60_956	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH60_96	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH60_960	COG1477	protein flavinylation
CH60_964	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH60_965	COG1805	sodium ion transport
CH60_966	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH60_967	COG0121	glutamine amidotransferase
CH60_968	COG3034	peptidoglycan biosynthetic process
CH60_97	COG0546	phosphoglycolate phosphatase activity
CH60_970	COG1960	acyl-CoA dehydrogenase activity
CH60_972	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH60_976	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH60_979	COG0582	viral genome integration into host DNA
CH60_98	COG0180	Tryptophanyl-tRNA synthetase
CH60_980	COG2963	transposase activity
CH60_982	COG0596	Alpha beta hydrolase
CH60_986	COG0735	belongs to the Fur family
CH60_991	COG2190	(PTS) system
CH60_991	COG1263	PTS System
CH60_991	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH60_993	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH60_994	COG1846	Transcriptional regulator
CH60_994	COG1940	carbohydrate kinase activity
CH60_995	COG0647	UMP catabolic process
CH60_996	COG0367	asparagine synthase