locus-tag	class	description
YerA41_051	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YerA41_064	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YerA41_066	COG0189	ligase activity
YerA41_068	COG0717	Belongs to the dCTP deaminase family
YerA41_100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YerA41_113	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YerA41_113	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YerA41_117	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YerA41_127	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YerA41_131	COG0551	DNA topoisomerase type I activity
YerA41_131	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YerA41_137	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YerA41_139	COG0085	RNA polymerase activity
YerA41_148	COG1028	Short-chain dehydrogenase reductase Sdr
YerA41_149	COG1028	Short-chain dehydrogenase reductase Sdr
YerA41_151	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
YerA41_151	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
YerA41_170c	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
YerA41_186c	COG3409	Peptidoglycan-binding domain 1 protein
YerA41_186c	COG3501	Rhs element vgr protein