locus-tag class description COG0846 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form COG1875 ATPase related to phosphate starvation-inducible protein PhoH COG0234 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter COG0162 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) COG1327 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes COG1328 CTP reductase activity COG3445 Acts as a radical domain for damaged PFL and possibly other radical proteins COG0602 queuosine metabolic process COG0236 Carrier of the growing fatty acid chain in fatty acid biosynthesis COG1435 thymidine kinase activity COG0617 tRNA 3'-terminal CCA addition COG0695 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins COG0494 nUDIX hydrolase COG0542 response to heat COG0234 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter COG0258 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity COG0749 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity COG0209 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides COG0208 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides COG0262 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis COG0328 RNA-DNA hybrid ribonuclease activity COG0507 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD COG0187 DNA topoisomerase II activity COG0188 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner COG3853 Toxic anion resistance protein (TelA) COG1734 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters COG0639 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP COG0740 serine-type endopeptidase activity COG1051 belongs to the nudix hydrolase family COG1056 cytidyltransferase-related domain