locus-tag class description CH64_1000 ENOG4105DY2 Paraquat-inducible protein b CH64_1001 ENOG4105F1S paraquat-inducible protein a CH64_1002 ENOG4105C5H ABC transporter CH64_1003 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CH64_1004 ENOG4105QVC MOSC domain-containing protein CH64_1005 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) CH64_1006 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CH64_1007 ENOG4105CD8 aminopeptidase N CH64_1008 ENOG4107RH7 Nicotinate phosphoribosyltransferase CH64_1009 ENOG4105C5S asparaginyl-tRNA synthetase CH64_101 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CH64_1011 ENOG4105CGF Aromatic amino acid aminotransferase CH64_1012 ENOG4105C5X domain protein CH64_1013 ENOG4105EAQ (twin-arginine translocation) pathway signal CH64_1014 ENOG4105DIT ErfK YbiS YcfS YnhG family protein CH64_1015 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) CH64_1016 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) CH64_1017 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) CH64_102 ENOG4108YZT Adenosylcobinamide kinase CH64_1020 ENOG4107S90 membrAne CH64_1021 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups CH64_1023 ENOG4105W49 UPF0434 protein CH64_1024 ENOG4105VEQ Cold shock protein CH64_1025 ENOG4105VEQ Cold shock protein CH64_1026 ENOG4105E32 cytoplasmic protein CH64_1027 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) CH64_1029 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 CH64_103 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) CH64_1030 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CH64_1031 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CH64_1032 ENOG4105CAT Cytidine monophosphate kinase CH64_1033 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CH64_1034 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CH64_1035 ENOG4107VMU Membrane CH64_1036 ENOG4105HDK L-asparaginase CH64_1037 ENOG4105DDY UPF0142 protein ycaO CH64_1038 ENOG4105TMB Formate nitrite transporter CH64_1039 ENOG4105C6N Formate acetyltransferase CH64_104 ENOG4108TGR phosphatase CH64_1040 ENOG4105F1A Pyruvate formate-lyase CH64_1041 ENOG4108ISG Major Facilitator CH64_1042 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CH64_1043 ENOG4105D1H recombination factor protein RarA CH64_1044 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) CH64_1045 ENOG4105CNU cell division protein FtsK CH64_1046 ENOG4105EW9 transcriptional regulator AsnC family CH64_1047 ENOG4105C3M thioredoxin reductase CH64_1048 ENOG4108JJ9 ABC, transporter CH64_1049 ENOG4108JJ8 (ABC) transporter CH64_105 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CH64_1051 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CH64_1052 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CH64_1053 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CH64_1054 ENOG4105VEQ Cold shock protein CH64_1056 ENOG4105DJY efflux transporter, rnd family, mfp subunit CH64_1057 ENOG4108MJ5 VirK protein CH64_1058 ENOG4105CPB ATP-dependent endonuclease of the OLD family CH64_1059 ENOG4105DWU Membrane CH64_1060 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CH64_1061 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CH64_1062 ENOG4105C7K acetolactate synthase CH64_1064 ENOG4105C5W Aldolase CH64_1065 ENOG4105CGD Nad-dependent epimerase dehydratase CH64_1066 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase CH64_1067 ENOG41064MM (LipO)protein CH64_1068 ENOG4105E5Z arginine transporter ATP-binding subunit CH64_1069 ENOG4106PMH Extracellular solute-binding protein family 3 CH64_107 ENOG4105UQX Mate efflux family protein CH64_1070 ENOG4105GBT ABC transporter CH64_1071 ENOG4105DMR ABC, transporter CH64_1072 ENOG4105DPW Major facilitator superfamily MFS_1 CH64_1073 ENOG4105C6F GntR Family Transcriptional Regulator CH64_1076 ENOG4105D6F Phosphatase CH64_1077 ENOG4106TNF Periplasmic binding protein CH64_1078 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) CH64_1079 ENOG4105RBQ inner membrane protein ybjO CH64_108 ENOG4107R88 Chemotaxis protein (CheV) CH64_1080 ENOG4105D38 putrescine abc transporter CH64_1081 ENOG4105F38 ABC transporter, permease CH64_1082 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH64_1083 ENOG4107RUE extracellular solute-binding protein family 1 CH64_1084 ENOG4108RMJ sensory transduction regulator CH64_1085 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress CH64_1086 ENOG41090BQ Glutaredoxin CH64_1087 ENOG4105D0C transport protein CH64_1091 ENOG4105MEH CH64_1098 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CH64_1099 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CH64_110 ENOG410679B prophage CP4-57 regulatory protein alpA CH64_1100 ENOG4107FB0 transcriptional regulator DeoR family CH64_1101 ENOG4105C44 Serine transporter CH64_1102 ENOG4105EJQ L-serine dehydratase CH64_1103 ENOG4105DZ1 carboxypeptidase CH64_1105 ENOG4105C28 cystathionine CH64_1106 ENOG4108UMI ABC transporter, permease CH64_1108 ENOG4105D01 (LipO)protein CH64_1112 ENOG4108TGY Glutathione S-transferase CH64_1113 ENOG4105D05 Receptor CH64_1114 ENOG4108IQI permease CH64_1115 ENOG4105DUM transcriptional regulator, lysR family CH64_1116 ENOG4105HMI Membrane CH64_1117 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CH64_1118 ENOG4105DM4 PTS System CH64_1119 ENOG4105DE4 1-phosphofructokinase CH64_1120 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CH64_1122 ENOG4105KRS Proteinase inhibitor CH64_1124 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CH64_1125 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CH64_1126 ENOG4105DEI Mannitol dehydrogenase CH64_1127 ENOG4107YCY Transcriptional regulator CH64_1129 ENOG4105CKI cobalamin synthesis protein CH64_1130 ENOG41076MN Phosphoesterase, PA-phosphatase related CH64_1131 ENOG4107TT5 NLP P60 protein CH64_1132 ENOG4105CXC rtn protein CH64_1133 ENOG4105E43 Extracellular solute-binding protein, family 5 CH64_1134 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component CH64_1135 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component CH64_1136 ENOG4108JQ5 ABC transporter CH64_1137 ENOG4105HG6 CH64_1139 ENOG4105C2C drug resistance transporter, Bcr CflA CH64_1140 ENOG4105I08 Pseudouridine synthase CH64_1141 ENOG4105CFI type iii restriction protein res subunit CH64_1143 ENOG4106V8H Nucleoid-associated protein CH64_1144 ENOG4105PAN UPF0352 protein CH64_1145 ENOG4105E68 Sulfatase CH64_1147 ENOG4105CS2 ec 3.2.1.21 CH64_1148 ENOG4105C5Y PTS System CH64_1149 ENOG4108Q3X Transcriptional regulator CH64_1150 ENOG4105Y50 Virulence Protein CH64_1151 ENOG4108NC2 Outer membrane protease CH64_1154 ENOG4105CT4 transporter CH64_1155 ENOG4107R6D beta-lactam binding protein AmpH CH64_1159 ENOG4106UW1 Major Facilitator superfamily CH64_1160 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC CH64_1161 ENOG41068CG regulatoR CH64_1162 ENOG4105BZU Histidine kinase CH64_1163 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH64_1164 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CH64_1165 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CH64_1166 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CH64_1167 ENOG4105XPH Ferredoxin CH64_1168 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) CH64_1170 ENOG4105E0U tyrosine-specific transport protein CH64_1171 ENOG4108UII YfaZ family CH64_1172 ENOG4105CH6 catalase CH64_1173 ENOG4105CEY Amp-dependent synthetase and ligase CH64_1174 ENOG4105DNI Converts SHCHC to OSB (By similarity) CH64_1175 ENOG4108IPT Naphthoate synthase CH64_1177 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CH64_1178 ENOG4105E4F Isochorismate synthase CH64_1180 ENOG4105TNS Conserved Protein CH64_1181 ENOG4105C01 Dihydroxy-acid dehydratase CH64_1182 ENOG41090KN UPF0303 protein CH64_1184 ENOG4105C5I Dehydrogenase CH64_1185 ENOG4105K2J Transcriptional regulator CH64_1186 ENOG4105CHR reductase CH64_1187 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CH64_1188 ENOG4108R66 Conserved Protein CH64_1189 ENOG4108UQ5 membrane protein YcdZ CH64_1191 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH64_1192 ENOG4105C8S subunit m CH64_1193 ENOG4105D65 subunit l CH64_1194 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH64_1195 ENOG4107UFS subunit j CH64_1196 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH64_1197 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CH64_1198 ENOG4108IEH NADH dehydrogenase subunit g CH64_1199 ENOG4107QIZ NADH dehydrogenase CH64_1200 ENOG4105GKE subunit e CH64_1201 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH64_1202 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH64_1203 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CH64_1204 ENOG4107NQ8 LysR family Transcriptional regulator CH64_1205 ENOG4105CHM Aminotransferase CH64_1206 ENOG4105DK2 UPF0207 protein CH64_1207 ENOG4107QWE )-transporter CH64_1209 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 CH64_1210 ENOG4105XWI UPF0304 protein CH64_1211 ENOG4105PQ6 UPF0208 membrane protein CH64_1213 ENOG4105C6K Malic enzyme CH64_1214 ENOG4107P2S Transcriptional regulator CH64_1215 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia CH64_1217 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC CH64_1218 ENOG4105PTV Nudix Hydrolase CH64_1219 ENOG4108RE9 Phosphodiesterase CH64_1221 ENOG4105ECP epimerase CH64_1222 ENOG4108JEH abc transporter atp-binding protein CH64_1223 ENOG4106YG3 ABC transporter CH64_1224 ENOG4105DSP amino acid AbC transporter CH64_1225 ENOG4105E89 ABC transporter CH64_1226 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CH64_1227 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CH64_1228 ENOG4105E96 Colicin v production protein CH64_1229 ENOG4108S3P Sporulation domain protein CH64_1230 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CH64_1231 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CH64_1232 ENOG4105DQR SNARE associated Golgi CH64_1234 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CH64_1235 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) CH64_1237 ENOG410631K Membrane CH64_1239 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CH64_1240 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CH64_1244 ENOG4106WZ1 flagella biosynthesis regulator CH64_1245 ENOG4105F4P )-transporter CH64_1246 ENOG4105D6F Phosphatase CH64_1249 ENOG4105CK1 PTS System CH64_125 ENOG4107UNZ domain protein CH64_1250 ENOG4105CS2 ec 3.2.1.21 CH64_1251 ENOG4105VCP PTS System CH64_1254 ENOG4105BZU Histidine kinase CH64_1255 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH64_1256 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) CH64_1257 ENOG4105MH2 YfcL protein CH64_1258 ENOG4108BPE -transporting atpase CH64_1259 ENOG4105EJ9 Membrane CH64_1260 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) CH64_1261 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CH64_1262 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) CH64_1263 ENOG4108DG9 Smr protein MutS2 CH64_1264 ENOG4108BY2 phosphohistidine phosphatase CH64_1265 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CH64_1266 ENOG4105CHU acetyl-coa acetyltransferase CH64_1267 ENOG4105KZW UPF0381 protein CH64_1268 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation CH64_1269 ENOG410903C (LipO)protein CH64_1270 ENOG4105KWW Biogenesis protein CH64_1271 ENOG4105KWW Biogenesis protein CH64_1272 ENOG4107QX9 Thiol disulfide interChange protein CH64_1273 ENOG4105DA4 cytochrome c-type biogenesis protein CH64_1274 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) CH64_1275 ENOG4105X3C heme exporter protein CH64_1276 ENOG41060IM Heme exporter protein CH64_1277 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) CH64_1279 ENOG4105S64 Formate nitrite transporter CH64_1281 ENOG4107QHE Choloylglycine hydrolase CH64_1282 ENOG4105C5I Dehydrogenase CH64_1284 ENOG4105CXK mandelate racemase muconate lactonizing CH64_1285 ENOG4108RTU Aldolase CH64_1286 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 CH64_1287 ENOG4105EMF GntR family transcriptional regulator CH64_1288 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CH64_1289 ENOG4105NTW Transcriptional regulator CH64_1291 ENOG4105CS2 ec 3.2.1.21 CH64_1292 ENOG4105C5Y PTS System CH64_1294 ENOG4106KR7 LysR family Transcriptional regulator CH64_1295 ENOG4108Q9V regulatoR CH64_1296 ENOG4105DDV Transcriptional regulator (LacI family CH64_1297 ENOG4108YYC ycei family CH64_1298 ENOG4105DS1 cytochrome b561 CH64_13 ENOG4107SDZ Galactoside transport system permease protein mglC CH64_1301 ENOG4105DHJ ABC, transporter CH64_1306 ENOG4105CUB amino acid CH64_1307 ENOG4105CVE Lytic murein transglycosylase CH64_1310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH64_1312 ENOG4107QY8 reductase CH64_1313 ENOG4105QAX Iron-sulfur CH64_1314 ENOG4107KGK dmso reductase anchor subunit CH64_1315 ENOG4108NEM leader-binding protein dmsD CH64_1317 ENOG4108VKM cytochrome b561 CH64_1318 ENOG4105CHM Aminotransferase CH64_1320 ENOG41072TH Protein of unknown function (DUF1479) CH64_1321 ENOG4108HRK Histidine kinase CH64_1322 ENOG4105DY9 regulatoR CH64_1323 ENOG4105FCD Major Facilitator CH64_1324 ENOG4105CHC glucokinase (EC 2.7.1.2) CH64_1326 ENOG4105C5Q Transcriptional regulator CH64_1327 ENOG4107RA9 decarboxylase CH64_1328 ENOG4105CPC Aldo Keto reductase CH64_1330 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CH64_1331 ENOG4105D9N nucleoside CH64_1332 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CH64_1333 ENOG4107GFK fumarate CH64_1334 ENOG41090KR LysR family transcriptional Regulator CH64_1335 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CH64_1336 ENOG4105JZC GHMP kinase CH64_1337 ENOG4107WFU Glutamate mutase subunit sigma CH64_1339 ENOG4105DJI Methylaspartate mutase, E subunit CH64_1343 ENOG4105CK2 sodium dicarboxylate symporter CH64_1349 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CH64_1354 ENOG4105VRT cytoplasmic protein CH64_1358 ENOG4105C6T cysteine synthase CH64_1359 ENOG4105KZ7 phosphocarrier protein hpr CH64_1361 ENOG4105C5Y PTS System CH64_1362 ENOG4105E0F Histidine kinase CH64_1363 ENOG4105E3W Two component transcriptional regulator (Winged helix family CH64_1364 ENOG4105DJY efflux transporter, rnd family, mfp subunit CH64_1366 ENOG4105C6T cysteine synthase CH64_1368 ENOG4105ECW sulfate abc transporter CH64_1369 ENOG4108I5D sulfate abc transporter CH64_137 ENOG4105D8D Type III CH64_1370 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein CH64_1372 ENOG4105QEK Transcriptional regulator CH64_1373 ENOG4108R66 Conserved Protein CH64_1377 ENOG4105EZR dyp-type peroxidase family protein CH64_1378 ENOG4105E7K (LipO)protein CH64_1379 ENOG4105H4F exported protein CH64_138 ENOG4107QMH DNA methylase CH64_1380 ENOG4108R6G acetyltransferase CH64_1381 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) CH64_1383 ENOG4105C6K Malic enzyme CH64_1384 ENOG4107VIJ nudix hydrolase CH64_1387 ENOG4105CUW cytochrome C-TYPE protein CH64_1389 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) CH64_1390 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CH64_1391 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase CH64_1394 ENOG4105WH1 Two component transcriptional regulator luxr family CH64_1396 ENOG4105BZS acriflavin resistance protein CH64_1398 ENOG4105KUZ arsenate reductase CH64_1399 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CH64_14 ENOG4105TMB Formate nitrite transporter CH64_1401 ENOG4105XYK UPF0370 protein CH64_1402 ENOG4106KED esterase YpfH CH64_1403 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) CH64_1404 ENOG4108VMM UPF0756 membrane protein CH64_1405 ENOG4105CGZ zinc metallopeptidase CH64_1406 ENOG4105C8V SAICAR synthetase CH64_1407 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CH64_1408 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CH64_1409 ENOG4105RH4 Glycine cleavage system transcriptional repressor CH64_1410 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CH64_1411 ENOG4105C02 permease CH64_1412 ENOG4105ERG peptidase m48, ste24p CH64_1413 ENOG4105K89 arsenate reductase CH64_1414 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) CH64_1415 ENOG4105C2W permease CH64_1416 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CH64_1418 ENOG4108V3E phosphoribosylglycinamide formyltransferase CH64_1419 ENOG4108MK9 spermidine N(1)-acetyltransferase CH64_1420 ENOG4108C80 FliB family CH64_1421 ENOG4108C80 FliB family CH64_1423 ENOG4105E2Z phosphate ABC transporter (Permease CH64_1424 ENOG4105C8U phosphate abc transporter CH64_1425 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CH64_1426 ENOG4105C9X ppx gppa phosphatase CH64_1428 ENOG4105CJW magnesium transporter CH64_1429 ENOG4105BZU Histidine kinase CH64_1430 ENOG4105R8A Heat shock protein CH64_1431 ENOG4105ENT Efflux transporter rnd family, mfp subunit CH64_1433 ENOG4105BZS acriflavin resistance protein CH64_1435 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH64_1436 ENOG4105EB3 Histidine kinase CH64_1437 ENOG4105E3W Two component transcriptional regulator (Winged helix family CH64_1438 ENOG4105KWI UPF0339 protein CH64_1439 ENOG4105CFP Peptidase U32 CH64_144 ENOG4108MQF Chaperone CH64_1440 ENOG4107TE5 Lipid kinase CH64_1441 ENOG410787A Pts system, glucitol sorbitol-specific CH64_1442 ENOG4105DZY Pts system, glucitol sorbitol-specific CH64_1443 ENOG4105VI0 Pts system, glucitol sorbitol-specific CH64_1444 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase CH64_1445 ENOG4105J92 DNA-binding transcriptional activator GutM CH64_1446 ENOG410804X Transcriptional regulator CH64_1448 ENOG4108ZGU inhibitor of vertebrate lysozyme CH64_1450 ENOG4105DWF phosphomethylpyrimidine kinase CH64_1453 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CH64_1454 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CH64_1455 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CH64_1456 ENOG4105VPD cellular component movement CH64_1458 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CH64_1459 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CH64_146 ENOG4105CW0 outer membrane usher protein CH64_1460 ENOG4105N21 Membrane CH64_1461 ENOG4105CUT histidyl-tRNA synthetase CH64_1462 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CH64_1463 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) CH64_1465 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CH64_1467 ENOG4108JQB penicillin-binding protein 1C CH64_1468 ENOG4105DN3 alpha-2-macroglobulin domain protein CH64_147 ENOG4105GQR Chaperone CH64_1470 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit CH64_1471 ENOG4108MGN ATP-binding component of a transport system CH64_1473 ENOG4108MGN ATP-binding component of a transport system CH64_1474 ENOG4105YYA enhanced serine sensitivity protein SseB CH64_1476 ENOG4105WVQ Fe-S assembly protein IscX CH64_1477 ENOG4108ZIT Ferredoxin, 2FE-2S CH64_1478 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB CH64_1479 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) CH64_1481 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins CH64_1482 ENOG4105C3J Cysteine desulfurase CH64_1483 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family CH64_1484 ENOG4105CVS RNA methyltransferase TrmH family, group 1 CH64_1486 ENOG4105D7X high-affinity nickel-transporter CH64_1487 ENOG41065CD Exported protein CH64_1488 ENOG4105D8G Major Facilitator superfamily CH64_1489 ENOG4108MN2 Stationary phase inducible protein CsiE CH64_149 ENOG4105BZU Histidine kinase CH64_1490 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CH64_1491 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CH64_1492 ENOG4108M21 CH64_1493 ENOG4108YZA Nitrogen regulatory protein pii CH64_1494 ENOG4105C4K Nad synthetase CH64_1495 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH64_1496 ENOG4108SKK alpha helix protein CH64_1497 ENOG4107WP9 Histidine kinase CH64_15 ENOG4108JUA Transcriptional regulator CH64_150 ENOG4108Q9V regulatoR CH64_1500 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) CH64_1501 ENOG4108Z6B deaminase CH64_1502 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB CH64_1504 ENOG4106G6Q Transcriptional regulator CH64_1505 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding CH64_1506 ENOG4107EFN gluconate transport system permease 3 CH64_1507 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CH64_1508 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) CH64_1509 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) CH64_1510 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CH64_1512 ENOG4105C3F Signal peptidase i CH64_1513 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CH64_1515 ENOG4105WMJ Positive regulator of sigma E, RseC MucC CH64_1516 ENOG4105VQK sigma E regulatory protein, MucB RseB CH64_1517 ENOG41069PW sigma-e factor negative regulatory protein CH64_1519 ENOG4108IYU L-aspartate oxidase CH64_1520 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) CH64_1521 ENOG4105C1J atp-dependent rna helicase CH64_1523 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) CH64_1524 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CH64_1525 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CH64_1526 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CH64_1527 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CH64_1528 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CH64_1530 ENOG4108Z1B Cyclase dehydrase CH64_1531 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CH64_1532 ENOG4105DFP Integrase CH64_1534 ENOG410679B prophage CP4-57 regulatory protein alpA CH64_1537 ENOG410693A DNA-binding protein CH64_1538 ENOG4105JXR Protein of unknown function (DUF3296) CH64_1542 ENOG4105C4R Atp-dependent dna helicase CH64_1550 ENOG4108MXD gtp-binding protein CH64_1551 ENOG4108KZE transcriptional regulator CH64_1553 ENOG4106J9S Prophage CH64_1554 ENOG4106H6R UPF0380 protein CH64_1555 ENOG4108XS9 dna repair protein CH64_1556 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles CH64_1557 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures CH64_1563 ENOG4105S66 prophage protein CH64_1564 ENOG410901P UPF0249 protein CH64_1565 ENOG4105EZV Transcriptional regulator CH64_1566 ENOG4105VCP PTS System CH64_1567 ENOG4105CS2 ec 3.2.1.21 CH64_1568 ENOG4105CK1 PTS System CH64_1569 ENOG4105VZJ PTS System CH64_157 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH64_1570 ENOG4105D8V Glucose sorbosone dehydrogenase CH64_1571 ENOG4105CPC Aldo Keto reductase CH64_1573 ENOG41086WQ Protein CrcB homolog CH64_1574 ENOG4107SVH Potassium channel protein CH64_1575 ENOG4105XXV Acid-resistance protein CH64_1578 ENOG4108XNJ Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CH64_1579 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CH64_158 ENOG4107RCV ABC transporter, permease CH64_1580 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CH64_1582 ENOG4105CQM Urea amidohydrolase subunit alpha CH64_1583 ENOG4105KI2 Urea amidohydrolase subunit beta CH64_1586 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) CH64_1588 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CH64_1589 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CH64_159 ENOG4105C4Y ABC transporter CH64_1593 ENOG4105VEQ Cold shock protein CH64_1595 ENOG4108SAJ Protein of unknown function (DUF1198) CH64_1596 ENOG4108WMJ Protein of unknown function (DUF2002) CH64_1597 ENOG4105F9N Major Facilitator Superfamily CH64_1599 ENOG4105NE1 Conserved Protein CH64_16 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CH64_160 ENOG4105CXY transporter CH64_1601 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CH64_1602 ENOG4105WAZ (Glutaredoxin-like protein) NrdH CH64_1603 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CH64_1605 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CH64_1606 ENOG4108IJ7 Glycine betaine CH64_1607 ENOG4108HQS Glycine betaine CH64_1608 ENOG4105GIJ Glycine betaine CH64_161 ENOG4105BZU Histidine kinase CH64_1610 ENOG4108JDX DNA polymerase iii, epsilon subunit CH64_1612 ENOG4105D1A Methyltransferase CH64_1613 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CH64_1614 ENOG4105E9H Lytic Murein transglycosylase CH64_1615 ENOG4107NA1 Endonuclease Exonuclease phosphatase CH64_1616 ENOG4105F27 Major Facilitator CH64_1617 ENOG4105HEI LysR family (Transcriptional regulator CH64_1618 ENOG4105CV8 reductase CH64_1619 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH64_162 ENOG4108KX4 response regulator CH64_1620 ENOG4105C2D reductase CH64_1622 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH64_1627 ENOG4107QJZ Glycosyl transferase, family 2 CH64_163 ENOG4106YYS transcriptional regulatory protein CH64_1632 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CH64_164 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CH64_1642 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CH64_1644 ENOG4108UMI ABC transporter, permease CH64_1645 ENOG4105D01 (LipO)protein CH64_1646 ENOG4108R8X outer membrane lipoprotein CH64_1647 ENOG4108R96 Methyltransferase, YaeB family CH64_1648 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CH64_1649 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion CH64_165 ENOG4105DUA (citrate (pro-3S)-lyase ligase CH64_1650 ENOG4108YZN class I peptide chain release factor CH64_1651 ENOG4108VWS Yaeq family CH64_1653 ENOG4105M1T rho-binding antiterminator CH64_1655 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CH64_1656 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CH64_1657 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CH64_1658 ENOG4105C0B DNA polymerase III (alpha subunit) CH64_1659 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CH64_166 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) CH64_1660 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CH64_1661 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CH64_1662 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CH64_1664 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) CH64_1666 ENOG4105DZP Membrane-associated zinc metalloprotease CH64_1667 ENOG4105KNE Phosphatidate cytidylyltransferase CH64_1668 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CH64_1669 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CH64_167 ENOG4105CI0 Citrate lyase CH64_1670 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CH64_1671 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CH64_1673 ENOG4105CE9 30S ribosomal protein S2 CH64_1674 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CH64_1675 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) CH64_1676 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) CH64_1677 ENOG4108T8E UPF0325 protein CH64_1678 ENOG4105QDK Flavodoxin CH64_1679 ENOG4105DR9 pseudouridine synthase CH64_168 ENOG4105CHY citrate lyase, alpha CH64_1680 ENOG4105WP7 tRNA pseudouridine synthase C CH64_1681 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) CH64_1682 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CH64_1683 ENOG4105EWT decarboxylase family CH64_1684 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease CH64_1685 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) CH64_1686 ENOG4105M08 Membrane CH64_1687 ENOG4105ETT transcriptional Regulator, LysR family CH64_1688 ENOG4105M5B (LipO)protein CH64_1689 ENOG4105C9B Cysteine desulfurase CH64_1690 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CH64_1691 ENOG4105CUZ uba thif-type nad fad binding protein CH64_1692 ENOG4105CA3 membrane-bound lytic murein transglycosylase CH64_1696 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CH64_1697 ENOG4107QZM n-acetylglutamate synthase CH64_1698 ENOG4107QYX exodeoxyribonuclease v alpha CH64_1699 ENOG4107QKA exodeoxyribonuclease V beta CH64_17 ENOG4108RC0 Electron transport protein CH64_170 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase CH64_1700 ENOG4107QXK peptidase CH64_1701 ENOG4105DSY exodeoxyribonuclease V, gamma CH64_1707 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CH64_1708 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase CH64_1709 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CH64_171 ENOG4107QPK )-transporter CH64_1710 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) CH64_1711 ENOG4105EE5 Membrane protein terC CH64_1712 ENOG4105CPC Aldo Keto reductase CH64_1713 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) CH64_1714 ENOG4105CEY Amp-dependent synthetase and ligase CH64_1716 ENOG41060NJ transcriptional regulator CH64_1717 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CH64_1718 ENOG4105RQF LysR family Transcriptional regulator CH64_1719 ENOG4105F27 Major Facilitator CH64_172 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH64_1720 ENOG4105EJC lysr family transcriptional regulator CH64_1725 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) CH64_1732 ENOG4108VAU general secretion pathway protein G CH64_1733 ENOG4105D7Q type ii secretion system CH64_1734 ENOG4107QHF type ii secretion system protein e CH64_1738 ENOG4107B2H carbonic anhydrase CH64_174 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH64_1740 ENOG4105DVC DnaJ domain protein CH64_1741 ENOG4105CQ4 Transcriptional regulator CH64_1742 ENOG4105DPW Major facilitator superfamily MFS_1 CH64_1745 ENOG4105F7P transcriptional regulator AsnC family CH64_1746 ENOG4105BZU Histidine kinase CH64_175 ENOG4108TSE Transferase CH64_1750 ENOG4105TNG K13735 adhesin invasin CH64_1754 ENOG4108WQH regulatoR CH64_1755 ENOG4107TT5 NLP P60 protein CH64_1756 ENOG4105PBD transposase, IS3 IS911 family protein CH64_1759 ENOG4106PG1 outer membrane usher protein CH64_1769 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CH64_1770 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CH64_1772 ENOG4105T95 Thiol disulfide interChange protein CH64_1773 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CH64_1774 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) CH64_1776 ENOG4105Y75 tpr repeat protein CH64_1777 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CH64_1779 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase CH64_1783 ENOG4108UT2 hemolysin iii CH64_1784 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CH64_1785 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CH64_1787 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CH64_1788 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CH64_1789 ENOG4105D0A hydroxylase CH64_1790 ENOG4107RAQ aminopeptidase CH64_1791 ENOG4105E07 UPF0149 protein CH64_1792 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CH64_1793 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CH64_1794 ENOG4108JQ1 Dehydrogenase CH64_1795 ENOG4105E66 phosphoriboisomerase A CH64_1796 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CH64_1797 ENOG4105MPN Membrane CH64_1798 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CH64_1799 ENOG4105D64 Mechanosensitive ion channel CH64_18 ENOG4108MG9 hydrogenase 3 maturation protease CH64_180 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) CH64_1801 ENOG4105D2N Aldolase CH64_1803 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CH64_1804 ENOG4105CV1 Transketolase (EC 2.2.1.1) CH64_1805 ENOG4108K0D peptidase, M48 CH64_1807 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) CH64_1811 ENOG41080HT Transcriptional regulator, arsr family CH64_1812 ENOG4105GPY SprT protein CH64_1813 ENOG4105RWS endonuclease I CH64_1814 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CH64_1815 ENOG4105D7Z glutathione synthase CH64_1817 ENOG4108UJU UPF0301 protein CH64_1818 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CH64_1819 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) CH64_182 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CH64_1821 ENOG4105CZX twitching motility protein CH64_1822 ENOG4105DFA alanine racemase domain protein CH64_1823 ENOG4105II7 pyrroline-5-carboxylate reductase CH64_1824 ENOG4108VIA integral membrane protein CH64_1825 ENOG4105VZ9 UPF0235 protein CH64_1826 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CH64_1827 ENOG4105CSA Coproporphyrinogen iii oxidase CH64_1828 ENOG4105K33 Periplasmic Protein CH64_1829 ENOG4105CSV Glutaminase CH64_183 ENOG4105D6F Phosphatase CH64_1830 ENOG41090ED Protein with unknown function (DUF469) CH64_1831 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CH64_1832 ENOG4105CEN a g-specific adenine glycosylase CH64_1834 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division CH64_1835 ENOG4105CXN decarboxylase CH64_184 ENOG41061EV selenium-binding protein YdfZ CH64_1841 ENOG4107TT5 NLP P60 protein CH64_1849 ENOG4105CKT filamentous hemagglutinin CH64_1852 ENOG4105CKT filamentous hemagglutinin CH64_1853 ENOG4105CKT filamentous hemagglutinin CH64_1858 ENOG4105CKT filamentous hemagglutinin CH64_186 ENOG4105J0Q Transcriptional regulator CH64_1862 ENOG4105CKT filamentous hemagglutinin CH64_1863 ENOG4105D5K Hemolysin activator protein CH64_1867 ENOG4105C26 Dehydrogenase CH64_1868 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) CH64_1869 ENOG4105CHR reductase CH64_187 ENOG4105GSJ Inner membrane protein ylaC CH64_1872 ENOG4108I5G Major Facilitator superfamily CH64_1873 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase CH64_1875 ENOG4108FUF Transcriptional regulator, IclR family CH64_189 ENOG4105CNT hydrolase family 2 CH64_1892 ENOG4105HA9 of methanol dehydrogenase type CH64_19 ENOG4105I6X formate hydrogenlyase maturation CH64_190 ENOG4105ETE Transcriptional regulator (LacI family CH64_1900 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CH64_191 ENOG4105VEQ Cold shock protein CH64_1911 ENOG4105DHQ Histidine kinase CH64_1912 ENOG4105R3P Inner membrane protein yagU CH64_1913 ENOG4105ETE Transcriptional regulator (LacI family CH64_1915 ENOG4105CT4 transporter CH64_1918 ENOG4108MI0 Resistance protein CH64_1919 ENOG4105J12 Multidrug resistance protein mdtN CH64_192 ENOG4105VZF DsrB protein CH64_1923 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CH64_1924 ENOG4108IPW abc transporter atp-binding protein CH64_1925 ENOG4105CM4 permease protein CH64_193 ENOG4105C8Q Methyl-accepting chemotaxis CH64_1930 ENOG4105ETE Transcriptional regulator (LacI family CH64_1932 ENOG4105EAM Na Pi-cotransporter CH64_1937 ENOG4105C1P efflux transporter, rnd family, mfp subunit CH64_1939 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase CH64_194 ENOG4105KT7 mgtC SapB transporter CH64_1941 ENOG4105C8H hydrogenase maturation protein Hypf CH64_1942 ENOG4105C45 hydrogenase expression formation protein (HypE) CH64_1943 ENOG4105CQS hydrogenase expression formation protein HypD CH64_1944 ENOG41082MF Hydrogenase assembly chaperone hypC hupF CH64_1945 ENOG4107RSS Hydrogenase accessory protein HypB CH64_1946 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CH64_1947 ENOG4108WGS hydrogenase 2-specific chaperone CH64_1948 ENOG4108USZ hydrogenase CH64_1949 ENOG4105DPX Hydrogenase, large subunit CH64_195 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CH64_1950 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit CH64_1951 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CH64_1952 ENOG4105E3S small subunit CH64_1953 ENOG4108XTF Outer Membrane Lipoprotein CH64_1955 ENOG4107RD7 Flagellar Motor Protein, MotA CH64_196 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CH64_1961 ENOG410804A Flagellar hook-associated 2 domain-containing protein CH64_1962 ENOG4105I03 Flagellin CH64_1963 ENOG4105I03 Flagellin CH64_1964 ENOG4105I03 Flagellin CH64_1968 ENOG4105DTJ flagellar hook-associated protein CH64_197 ENOG4108VA4 Universal stress protein CH64_1971 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) CH64_1973 ENOG4105CGA flagellar basal-body rod protein FlgG CH64_1974 ENOG4108KPB Flagellar basal-body rod protein FlgF CH64_1975 ENOG4105BZE flagellar hook protein, FlgE CH64_1976 ENOG4105W00 Flagellar hook capping protein CH64_1977 ENOG4108ZC9 flagellar basal-body rod protein flgc CH64_1978 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CH64_1983 ENOG4108JIR Flagellum-specific ATP synthase CH64_1986 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CH64_1987 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CH64_1988 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH64_199 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) CH64_1990 ENOG4105DD5 Flagellar motor switch protein CH64_1991 ENOG4105CN7 Flagellar biosynthetic protein FliP CH64_1992 ENOG4105VS8 Flagellar biosynthetic protein fliq CH64_1993 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CH64_1994 ENOG4105D00 flagellar biosynthetic protein flhB CH64_1997 ENOG4105C8Q Methyl-accepting chemotaxis CH64_1998 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein CH64_1999 ENOG4105DQ5 transport system permease protein CH64_20 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit CH64_200 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region CH64_2000 ENOG4105TVJ transport system, permease CH64_2001 ENOG4105E0A ABC, transporter CH64_2006 ENOG4105EP1 Efflux transporter rnd family, mfp subunit CH64_2007 ENOG4108IJF Heavy metal efflux pump, CzcA CH64_201 ENOG4107RD7 Flagellar Motor Protein, MotA CH64_202 ENOG4105ER2 Ompa motb domain protein CH64_2022 ENOG4108ZZF transport protein (ExbD) CH64_2023 ENOG4105CWK Biopolymer transport protein, ExbB CH64_2024 ENOG4105C28 cystathionine CH64_2025 ENOG4108K81 inner membrane protein YghB CH64_2026 ENOG4105CF7 AraC family transcriptional regulator CH64_2027 ENOG4108I6A alcohol dehydrogenase CH64_2028 ENOG4105CV8 reductase CH64_203 ENOG4105CBS Chea signal transduction histidine kinase CH64_2030 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) CH64_2031 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase CH64_2032 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH64_2033 ENOG4105NF4 modulator of drug activity CH64_2034 ENOG4105VRH Antibiotic biosynthesis monooxygenase CH64_2035 ENOG4105JQN Transcriptional regulator CH64_2036 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH64_2037 ENOG4105IPS esterase CH64_2038 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CH64_2039 ENOG4108SX3 cytoplasmic protein CH64_204 ENOG4108V3W Chemotaxis protein, CheW CH64_2040 ENOG41087AY ADP-Ribose pyrophosphatase CH64_2042 ENOG4105DFG type I secretion outer membrane protein CH64_2044 ENOG4106032 Glutathionylspermidine synthase CH64_2045 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CH64_2047 ENOG4105W0Z cytoplasmic protein CH64_2048 ENOG4105DVH amino acid CH64_2049 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CH64_205 ENOG4105C8Q Methyl-accepting chemotaxis CH64_2050 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CH64_2051 ENOG4105I7R Adenylate cyclase CH64_2052 ENOG4106MWK domain protein CH64_2053 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CH64_2054 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CH64_2055 ENOG4107ZVW dihydroneopterin aldolase CH64_2056 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CH64_2057 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CH64_2058 ENOG4105VCC 30S ribosomal protein S21 CH64_2059 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CH64_206 ENOG4105C8Q Methyl-accepting chemotaxis CH64_2060 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH64_2063 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures CH64_2065 ENOG4108XS9 dna repair protein CH64_207 ENOG4105BZU Histidine kinase CH64_2077 ENOG4108KZE transcriptional regulator CH64_2078 ENOG4106H6R UPF0380 protein CH64_2079 ENOG4108MXD gtp-binding protein CH64_2085 ENOG4105D8D Type III CH64_2087 ENOG4107NPW Protein of unknown function (DUF1524) CH64_209 ENOG4108VYJ response regulator receiver protein CH64_2091 ENOG4108W76 histidinol phosphate phosphatase hisj family CH64_2094 ENOG4108QDQ Ubiquinol-cytochrome C chaperone CH64_2096 ENOG4105JXR Protein of unknown function (DUF3296) CH64_2097 ENOG4108P8R CH64_210 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) CH64_2100 ENOG4105MZU cell filamentation protein CH64_2106 ENOG4105CH6 catalase CH64_2109 ENOG4105CMR udp-glucose 4-epimerase CH64_211 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin CH64_2111 ENOG4107RA4 Glycosyl transferase (Group 1 CH64_2112 ENOG4107QPH glycogen) synthase CH64_2117 ENOG4105DAY polysaccharide export protein CH64_2119 ENOG4105D3Q Sugar transferase CH64_212 ENOG4105D00 flagellar biosynthetic protein flhB CH64_2120 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) CH64_2121 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CH64_2122 ENOG4105C5Y PTS System CH64_2123 ENOG4105CSV Glutaminase CH64_2124 ENOG4105E5D amino acid CH64_2125 ENOG4105CVK Glutamate decarboxylase CH64_2126 ENOG4108YK4 Acid-resistance membrane protein CH64_2127 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CH64_2128 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) CH64_213 ENOG4105D7B Flagellar biosynthesis protein flha CH64_2130 ENOG4108VKG metal-dependent hydrolase CH64_2131 ENOG4105EE0 oxidoreductase CH64_2132 ENOG4105DU1 integral membrane protein, terc CH64_2133 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) CH64_2134 ENOG4105P66 Membrane CH64_2135 ENOG4105CTX dehydratase CH64_2136 ENOG4107QZW Altronate oxidoreductase CH64_2137 ENOG4105D2H Uronic isomerase CH64_2138 ENOG4105DPW Major facilitator superfamily MFS_1 CH64_214 ENOG4105W13 flagellar protein CH64_2141 ENOG4106W5V Membrane CH64_2144 ENOG4105NE1 Conserved Protein CH64_2145 ENOG41090KG Inner membrane protein YqjE CH64_2146 ENOG4105YJD CH64_2147 ENOG4108VBZ doxx family CH64_2148 ENOG4105CHF Glutathione S-transferase CH64_2149 ENOG4105CWB LysR family transcriptional Regulator CH64_215 ENOG4105QVD Flagella synthesis protein FlgN CH64_2150 ENOG4108CNN domain protein CH64_2151 ENOG4105DQ4 alcohol dehydrogenase CH64_2152 ENOG4105Y49 secretion protein, HlyD family CH64_2156 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CH64_2158 ENOG4107Z6I Thiamine biosynthesis protein CH64_2159 ENOG4105DEN Luciferase family CH64_216 ENOG4105M9M anti-sigma28 factor FlgM CH64_2161 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CH64_2163 ENOG41082RQ UPF0102 protein CH64_2164 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CH64_2165 ENOG4105W4M Transport-associated protein CH64_2166 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase CH64_2167 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain CH64_2168 ENOG4105BZU Histidine kinase CH64_2169 ENOG4105N5T Radical SAM Protein CH64_217 ENOG4105CKS Flagella basal body P-ring formation protein flgA CH64_2170 ENOG4105CBC glutamate synthase CH64_2171 ENOG4105BZ8 glutamate synthase CH64_2173 ENOG4105KB2 stringent starvation protein b CH64_2174 ENOG4107MKT Stringent starvation protein a CH64_2175 ENOG4108UJD 30S ribosomal protein S9 CH64_2176 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CH64_2177 ENOG4105D6Z AFG1 family ATPase CH64_2178 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III CH64_2179 ENOG4105C0H protease CH64_218 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CH64_2180 ENOG4105C0H protease CH64_2181 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CH64_2182 ENOG4105VFK BolA family CH64_2183 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane CH64_2184 ENOG4105E3I toluene tolerance CH64_2185 ENOG4107PE3 Mammalian cell entry related domain protein CH64_2186 ENOG4105CY3 ABC transporter, permease CH64_2187 ENOG4105DHJ ABC, transporter CH64_2188 ENOG4105FEU K -dependent Na -Ca exchanger CH64_2189 ENOG4105C2X Arabinose 5-phosphate isomerase CH64_219 ENOG4108ZC9 flagellar basal-body rod protein flgc CH64_2190 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase CH64_2191 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) CH64_2192 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA CH64_2193 ENOG4108IUZ ABC transporter CH64_2194 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH64_2195 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA CH64_2196 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN CH64_2197 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CH64_2198 ENOG41080Z8 PHOSPHOCARRIER protein CH64_22 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH64_220 ENOG4105W00 Flagellar hook capping protein CH64_2200 ENOG4105CXT aspartate transcarbamylase CH64_2201 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) CH64_2202 ENOG4105KME endoribonuclease L-psp CH64_2203 ENOG4105CG3 alpha amylase, catalytic region CH64_2204 ENOG4105C5Y PTS System CH64_2205 ENOG4105D4X repressor CH64_2207 ENOG4105EMD TRANSCRIPTIONal CH64_221 ENOG4105BZE flagellar hook protein, FlgE CH64_2210 ENOG41069H0 dihydroorotase EC 3.5.2.3 CH64_2216 ENOG4105NXH GreA GreB family elongation factor CH64_2217 ENOG4108XVM Cytochrome b(562) CH64_2218 ENOG4105CMS peptidase U62, modulator of DNA gyrase CH64_222 ENOG4108KPB Flagellar basal-body rod protein FlgF CH64_2220 ENOG4105UNR (Barnase) inhibitor CH64_2223 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) CH64_2224 ENOG4105Y49 secretion protein, HlyD family CH64_2225 ENOG4105ZQC membrane protein AaeX CH64_2226 ENOG4105CR8 Transcriptional regulator CH64_2227 ENOG4105D1U peptidase U62 modulator of DNA gyrase CH64_2229 ENOG4105QD6 exported protein CH64_223 ENOG4105CGA flagellar basal-body rod protein FlgG CH64_2230 ENOG4105C03 ribonuclease CH64_2232 ENOG4105VQ7 Rod shape-determining protein MreD CH64_2233 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CH64_2234 ENOG4105DFF Rod shape-determining protein mreb CH64_2235 ENOG41062P1 Diguanylate cyclase phosphodiesterase CH64_2236 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family CH64_2238 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) CH64_2239 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CH64_2240 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CH64_2241 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CH64_2242 ENOG4105RG0 Membrane CH64_2243 ENOG4108IA2 Sodium pantothenate symporter CH64_2244 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CH64_2245 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CH64_2246 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) CH64_2247 ENOG4105BZU Histidine kinase CH64_2248 ENOG4108XTF Outer Membrane Lipoprotein CH64_2249 ENOG4105VEQ Cold shock protein CH64_2250 ENOG4105VEQ Cold shock protein CH64_2251 ENOG4105VEQ Cold shock protein CH64_2252 ENOG4105D1S lipid A biosynthesis CH64_2256 ENOG4105EZ7 amino acid ABC transporter CH64_2257 ENOG4105DRP amino acid AbC transporter CH64_2258 ENOG4105CDA abc transporter atp-binding protein CH64_226 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CH64_2260 ENOG4105EEQ Na H antiporter CH64_2261 ENOG4105C7N Xanthine uracil vitamin C permease CH64_2263 ENOG4108UUM single-stranded DNA-binding protein CH64_2264 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CH64_2265 ENOG4105MSB protein, conserved in bacteria CH64_2266 ENOG4105CGF Aromatic amino acid aminotransferase CH64_2267 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CH64_2268 ENOG4105CDU Replicative dna helicase CH64_2269 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CH64_227 ENOG4105E1Q flagellar hook-associated protein CH64_2270 ENOG4105P4Z Phage shock protein G CH64_2271 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CH64_2272 ENOG4105EXC Acyl-transferase CH64_2273 ENOG4105MYN Zinc uptake regulation protein CH64_2274 ENOG4105VDW Csbd family CH64_2275 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CH64_2276 ENOG41080IJ Diacylglycerol kinase CH64_2277 ENOG4105E55 glycerol-3-phosphate acyltransferase CH64_2279 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) CH64_228 ENOG4105DTJ flagellar hook-associated protein CH64_2281 ENOG4107W52 maltose operon periplasmic protein CH64_2282 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CH64_2285 ENOG4107FKK extracellular solute-binding protein family 1 CH64_2286 ENOG4105D56 permease protein CH64_2287 ENOG4105EG2 ABC transporter, permease CH64_2288 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CH64_229 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CH64_2290 ENOG4105CFH Aspartokinase CH64_2291 ENOG4105C3R Methionine synthase CH64_2292 ENOG41069M3 Transcriptional regulator CH64_2293 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) CH64_2294 ENOG4108I9X Isocitrate lyase CH64_2295 ENOG4107QP3 malate synthase g CH64_2296 ENOG4105CVG Homoserine O-transsuccinylase CH64_23 ENOG4108JPZ Monovalent cation H antiporter subunit D CH64_230 ENOG4105VS8 Flagellar biosynthetic protein fliq CH64_2304 ENOG4108Z0R Transferase CH64_2305 ENOG4105E2X shikimate dehydrogenase CH64_2306 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CH64_2307 ENOG4108WI1 Dna topoisomerase CH64_2309 ENOG4105C79 DNA protecting protein DprA CH64_231 ENOG4105CN7 Flagellar biosynthetic protein FliP CH64_2310 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CH64_2311 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CH64_2312 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CH64_2313 ENOG4105C1A potassium transporter peripheral membrane CH64_2314 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CH64_2315 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system CH64_2316 ENOG4105W1Y Transcriptional regulator CH64_2317 ENOG4105VTS DnaJ-like, subfamily C CH64_2318 ENOG4108ZT0 50S ribosomal protein l17 CH64_2319 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CH64_2320 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CH64_2322 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CH64_2323 ENOG41067V7 50S ribosomal protein L36 CH64_2324 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CH64_2325 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CH64_2326 ENOG4105VPB 50S ribosomal protein L30 CH64_2327 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CH64_233 ENOG4105DD5 Flagellar motor switch protein CH64_2331 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CH64_2335 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CH64_2336 ENOG41083MP 50s ribosomal protein l29 CH64_2337 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CH64_2338 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CH64_2339 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CH64_234 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CH64_2340 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CH64_2341 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CH64_2342 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CH64_2344 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CH64_235 ENOG4107ZI8 flagellar basal body-associated protein flil CH64_2350 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CH64_2352 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CH64_2353 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CH64_2354 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) CH64_2355 ENOG4105WWK YheO domain protein CH64_2356 ENOG4108V1T peptidylprolyl cis-trans isomerase CH64_2358 ENOG4108YZY peptidylprolyl cis-trans isomerase CH64_2359 ENOG4105VKU nucleicacid-binding protein CH64_236 ENOG4105WF4 Flagellar hook-length control protein CH64_2361 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CH64_2362 ENOG4105C5H ABC transporter CH64_2363 ENOG4105K64 Glycosyl transferase, family 2 CH64_2365 ENOG4105JAB phenazine biosynthesis protein, phzf family CH64_2367 ENOG4105DNZ Alpha Beta Hydrolase CH64_2368 ENOG4105YP7 UPF0270 protein CH64_2369 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) CH64_237 ENOG4105GSA Flagellar export protein flij CH64_2370 ENOG4108UKZ OsmC family CH64_2372 ENOG410613R integral membrane protein, YccS YhfK family CH64_2373 ENOG4105C8Y Acetylornithine aminotransferase CH64_2375 ENOG4105D7A ATP-binding protein CH64_2376 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CH64_2377 ENOG4105F8D glycoside hydrolase family 4 CH64_2378 ENOG41060NJ transcriptional regulator CH64_2379 ENOG4106DTQ Protein TsgA homolog CH64_238 ENOG4108JIR Flagellum-specific ATP synthase CH64_2380 ENOG4105DZC cytosine deaminase CH64_2381 ENOG4107QZF nitrite reductase NADPH large subunit CH64_2382 ENOG4105WZK nitrite reductase NADPH small subunit CH64_2383 ENOG4107V9H nitrite transporter CH64_2384 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CH64_2385 ENOG4105C31 Tryptophanyl-tRNA synthetase CH64_2386 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CH64_2387 ENOG4105DJV ribulose-phosphate 3-epimerase CH64_239 ENOG41090PJ Flagellar assembly protein CH64_2391 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CH64_2392 ENOG4105E4G Type IV pilus CH64_2398 ENOG4108JQC penicillin-binding protein 1A CH64_2399 ENOG4107RK2 ADP-ribose diphosphatase NudE CH64_24 ENOG4107WQX hydrogenase 4 membrane subunit CH64_240 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CH64_2400 ENOG4105DQY intracellular growth attenuator CH64_2401 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 CH64_2402 ENOG4105VEJ Heat shock protein CH64_2404 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase CH64_2405 ENOG4105E0F Histidine kinase CH64_2406 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CH64_2407 ENOG4108RRZ Transcription elongation factor GreB CH64_2408 ENOG4105BZM domain protein CH64_2409 ENOG4105XFK Ferrous iron transport protein A CH64_241 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CH64_2411 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) CH64_2412 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CH64_2413 ENOG4105MJ2 Competence protein CH64_2414 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) CH64_2415 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) CH64_2416 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CH64_2417 ENOG41061ZR Transcriptional regulator CH64_242 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CH64_2420 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) CH64_2421 ENOG4105E98 transcriptional regulator DeoR family CH64_2422 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CH64_2423 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CH64_2424 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CH64_2425 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CH64_2426 ENOG4108IUM Glycogen debranching enzyme CH64_2427 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CH64_2428 ENOG4108HRK Histidine kinase CH64_2429 ENOG4108MBX Secretion Protein CH64_2431 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CH64_2432 ENOG41076UM multiple antibiotic resistance (MarC)-related protein CH64_2433 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CH64_2434 ENOG4105C6Z Gluconate CH64_2435 ENOG4105DIQ Transcriptional regulator CH64_2436 ENOG4105C2I pirin domain protein CH64_2437 ENOG4105WCN acetyltransferase CH64_2438 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CH64_2439 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CH64_2443 ENOG4105DH8 myo-inositol catabolism CH64_2444 ENOG4105C26 Dehydrogenase CH64_2446 ENOG4105EQ0 Major Facilitator superfamily CH64_2447 ENOG4105CR8 Transcriptional regulator CH64_245 ENOG4105DHT Metal Dependent Phosphohydrolase CH64_2450 ENOG41066YJ Beta-lactamase CH64_2451 ENOG4105CBX hi0933 family CH64_2453 ENOG4105CJ3 phosphate transporter CH64_2454 ENOG4108V6B universal stress protein B CH64_2456 ENOG4108M6U Universal stress protein A CH64_2459 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) CH64_2460 ENOG4105DGW oligopeptidase A CH64_2462 ENOG4105D6S protein involved in catabolism of external DNA CH64_2463 ENOG4105DC8 reductase CH64_2464 ENOG4107H3J ribonuclease CH64_2465 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) CH64_2466 ENOG41066T0 asmA family CH64_2467 ENOG4105CMB EAL domain-containing protein CH64_2468 ENOG4105VSH 4-oxalocrotonate tautomerase CH64_2469 ENOG4107SS6 2-dehydro-3-deoxygluconokinase CH64_247 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) CH64_2470 ENOG4105CS0 peptidase CH64_2471 ENOG4105CK2 sodium dicarboxylate symporter CH64_2473 ENOG4108PU9 oligogalacturonate-specific porin CH64_2474 ENOG4105BZU Histidine kinase CH64_2475 ENOG4108JQ7 (ABC) transporter CH64_2476 ENOG4105C3U ABC transporter CH64_2477 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CH64_2478 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CH64_2479 ENOG4105DEF Extracellular solute-binding protein, family 5 CH64_248 ENOG4105MQ3 flagellar protein FliS CH64_2481 ENOG4105CKT filamentous hemagglutinin CH64_2482 ENOG4105D5K Hemolysin activator protein CH64_2483 ENOG4105CKT filamentous hemagglutinin CH64_2485 ENOG4105CXY transporter CH64_2486 ENOG4105BZU Histidine kinase CH64_2487 ENOG4108KX4 response regulator CH64_2488 ENOG4105DIJ Phosphoethanolamine transferase CH64_2489 ENOG4108ZHJ Organic hydroperoxide resistance protein CH64_249 ENOG4105DTS flagellar hook-associated CH64_2490 ENOG4105K56 Transcriptional regulator CH64_2492 ENOG4105C85 amino acid CH64_2493 ENOG4105C84 Histidine ammonia-lyase CH64_2494 ENOG4105CGP Urocanate hydratase CH64_2495 ENOG4108Q2J Inner membrane protein YebE CH64_2497 ENOG4105T16 Transcriptional regulator (AraC family) CH64_2498 ENOG4107RNG ABC transporter CH64_25 ENOG4105D65 subunit l CH64_250 ENOG4105I03 Flagellin CH64_2500 ENOG4105DFW ABC transporter CH64_2501 ENOG4105C93 Xylose Isomerase CH64_2502 ENOG4105CMG Carbohydrate kinase CH64_2503 ENOG4108RWI nicotinamidase CH64_2504 ENOG4105MEV Acyl-transferase CH64_2508 ENOG4105EM7 Selenocysteine-specific translation elongation factor CH64_2509 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) CH64_2511 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) CH64_2512 ENOG4108MG3 formate dehydrogenase CH64_2513 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CH64_2514 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CH64_2515 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CH64_2516 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CH64_2518 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CH64_2519 ENOG4105C8Q Methyl-accepting chemotaxis CH64_252 ENOG4105I03 Flagellin CH64_2520 ENOG4108RPX mosc domain containing protein CH64_2521 ENOG4108YYI Protein of unknown function (DUF2810) CH64_2522 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CH64_2524 ENOG4105E61 Mannitol repressor protein CH64_2525 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase CH64_2526 ENOG4105CTS PTS system mannitol-specific CH64_2527 ENOG4106JH6 (LipO)protein CH64_2528 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CH64_2529 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit CH64_253 ENOG4108C80 FliB family CH64_2530 ENOG4108R3E Dna-3-methyladenine glycosylase i CH64_2535 ENOG4105C5I Dehydrogenase CH64_2536 ENOG4107T9C Alpha amylase catalytic region CH64_2537 ENOG4105JKW Valine--pyruvate aminotransferase CH64_2538 ENOG4105D0C transport protein CH64_254 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH64_2541 ENOG4105R2A (LipO)protein CH64_2542 ENOG4105D99 atp gtp-binding protein CH64_2543 ENOG4108SGR YheO domain-containing protein CH64_2544 ENOG4105C7B Threonine dehydratase CH64_2546 ENOG410667J hydrolase CH64_2547 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH64_2548 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CH64_2549 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CH64_255 ENOG4108M9K flagella biosynthesis protein FliZ CH64_2551 ENOG4105VG0 50S ribosomal protein l34 CH64_2552 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CH64_2554 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CH64_2555 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CH64_2556 ENOG4105RKW reductase (By CH64_2559 ENOG4108UMI ABC transporter, permease CH64_256 ENOG4105K6H D-cysteine desulfhydrase CH64_2560 ENOG4105C8Q Methyl-accepting chemotaxis CH64_2561 ENOG4108YYH Nadph-dependent fmn reductase CH64_2562 ENOG4105BZU Histidine kinase CH64_2565 ENOG4105C7N Xanthine uracil vitamin C permease CH64_2566 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 CH64_2567 ENOG4105DRP amino acid AbC transporter CH64_2568 ENOG4105EAD ABC transporter CH64_2569 ENOG4106PMH Extracellular solute-binding protein family 3 CH64_257 ENOG4105EAB amino acid AbC transporter CH64_2571 ENOG4105EHZ conserved protein UCP016719 CH64_2573 ENOG4105D17 glycoside hydrolase, family 3 domain protein CH64_2576 ENOG4105E2Z phosphate ABC transporter (Permease CH64_2577 ENOG4105C8U phosphate abc transporter CH64_2578 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) CH64_258 ENOG4105E5Q amino acid AbC transporter CH64_2580 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CH64_2581 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CH64_2582 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CH64_2583 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CH64_2585 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CH64_2587 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CH64_2588 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CH64_2589 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) CH64_259 ENOG4105CDA abc transporter atp-binding protein CH64_2590 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation CH64_2591 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CH64_2592 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CH64_2593 ENOG4105QTB Flavodoxin CH64_2594 ENOG4108VVK transcriptional Regulator, AsnC CH64_2597 ENOG4105EV2 VWA domain protein interacting with AAA ATPase CH64_2598 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) CH64_26 ENOG4107TDF Formate hydrogenlyase subunit 4 CH64_2600 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) CH64_2602 ENOG4105CNN ABC, transporter CH64_2603 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CH64_2604 ENOG4108RVA ribokinase CH64_2605 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH64_2606 ENOG4105ETE Transcriptional regulator (LacI family CH64_2607 ENOG4107EJG GntR family transcriptional regulator CH64_2612 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b CH64_2614 ENOG4105PC1 Conserved Protein CH64_2615 ENOG4105E27 serine threonine protein kinase CH64_2616 ENOG4108Z33 Thiol disulfide Interchange Protein CH64_2617 ENOG4105C2M dna polymerase I CH64_262 ENOG4105C26 Dehydrogenase CH64_2620 ENOG4105D4P Coproporphyrinogen iii oxidase CH64_2621 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH64_2622 ENOG4105CUX Signal transduction histidine kinase CH64_2623 ENOG4105C5F glutamine synthetase CH64_2625 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 CH64_2626 ENOG4107S2Z UPF0761 membrane protein CH64_2627 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CH64_2628 ENOG4105SUU thioesterase domain CH64_2629 ENOG4105HVQ Regulatory factor of maltose metabolism CH64_263 ENOG4105CK7 Sodium proline symporter CH64_2630 ENOG4108Q9V regulatoR CH64_2632 ENOG4105JV1 AsmA family CH64_2633 ENOG4105C2W permease CH64_2634 ENOG4105D6U Sodium Glutamate Symporter CH64_2635 ENOG4105CB5 ATP-dependent DNA helicase recG CH64_2636 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase CH64_2637 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CH64_2638 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CH64_2640 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) CH64_2641 ENOG4105EN6 Membrane CH64_2642 ENOG4105E39 Enoyl-CoA hydratase CH64_2643 ENOG4105BZU Histidine kinase CH64_2644 ENOG4105DSJ YicC domain protein CH64_2646 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CH64_2647 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CH64_2648 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CH64_2649 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CH64_2650 ENOG4105W5Q DNA repair protein (RadC CH64_2651 ENOG4105KDC 50s ribosomal protein l28 CH64_2652 ENOG4105W0E 50S ribosomal protein L33 CH64_2653 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CH64_2654 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CH64_2656 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase CH64_2657 ENOG4105D16 lipopolysaccharide heptosyltransferase i CH64_2658 ENOG4105XA0 heptosyltransferase ii CH64_2659 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CH64_2660 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CH64_2662 ENOG4105PXI polysaccharide deacetylase CH64_2663 ENOG41063SB peptidase CH64_2664 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CH64_2665 ENOG4107YZP Rhodanese domain protein CH64_2666 ENOG4105VW4 glutaredoxin 3 CH64_2667 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) CH64_2668 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CH64_2669 ENOG4105D7W serine acetyltransferase CH64_2670 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CH64_2671 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CH64_2672 ENOG4105E0F Histidine kinase CH64_2673 ENOG4105E3W Two component transcriptional regulator (Winged helix family CH64_2674 ENOG4105FMW periplasmic CH64_2675 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CH64_2677 ENOG41076HS cation diffusion facilitator family transporter CH64_2679 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CH64_268 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) CH64_2682 ENOG4105EBK exported protein CH64_2683 ENOG4108VTS Membrane CH64_2684 ENOG4105DP0 ferredoxin-NADP reductase CH64_2685 ENOG4105E5M Multidrug resistance protein D CH64_2686 ENOG4105CBT Fructose-1,6-bisphosphatase CH64_2687 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CH64_2688 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CH64_2689 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) CH64_2690 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) CH64_2691 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CH64_2692 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CH64_2693 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CH64_2694 ENOG41063M6 Cell Division Protein CH64_2695 ENOG4105ETE Transcriptional regulator (LacI family CH64_2696 ENOG4105C25 Primosomal protein n' CH64_2697 ENOG4105VFB Binds the 23S rRNA (By similarity) CH64_2698 ENOG4106EE1 CH64_2699 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) CH64_27 ENOG4108JPZ Monovalent cation H antiporter subunit D CH64_2700 ENOG4105C28 cystathionine CH64_2701 ENOG4105CFH Aspartokinase CH64_2702 ENOG4105SYT Methylenetetrahydrofolate reductase CH64_2703 ENOG4105CSH Transporter CH64_2704 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) CH64_2707 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CH64_2709 ENOG4105CH7 arginosuccinase CH64_271 ENOG4105FE9 pseudouridine synthase CH64_2710 ENOG4105X58 receptor CH64_2714 ENOG4107QZV Type I secretion membrane fusion protein CH64_2716 ENOG4107QN2 dihydrolipoyl dehydrogenase CH64_2717 ENOG4105EHV domain protein CH64_2719 ENOG4105C5Q Transcriptional regulator CH64_2720 ENOG4105EJ2 Transcriptional regulator CH64_2721 ENOG4108Y73 Membrane CH64_2722 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) CH64_2724 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CH64_2732 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator CH64_2733 ENOG4105C2J ABC transporter CH64_2734 ENOG4107R9N ABC transporter CH64_2735 ENOG4105CVI Transcriptional regulator CH64_2736 ENOG41062B0 ABC transporter, permease CH64_2737 ENOG4108WFC UPF0438 protein yifE CH64_2738 ENOG4105C0P Mg chelatase subunit ChlI CH64_274 ENOG4105E5K Alpha-amylase CH64_2740 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit CH64_2741 ENOG4105CM2 brancheD-chain amino acid aminotransferase CH64_2742 ENOG4105C01 Dihydroxy-acid dehydratase CH64_2743 ENOG4105C7B Threonine dehydratase CH64_2744 ENOG4105EMY transcriptional regulator CH64_2745 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CH64_2746 ENOG4108VEV chaperone CH64_2748 ENOG4105CW0 outer membrane usher protein CH64_2749 ENOG4105GQR Chaperone CH64_275 ENOG4105C8Q Methyl-accepting chemotaxis CH64_2751 ENOG4105KQ5 peptidylprolyl cis-trans isomerase CH64_2752 ENOG4105C4R Atp-dependent dna helicase CH64_2754 ENOG4105C9X ppx gppa phosphatase CH64_2756 ENOG4105K63 Thioredoxin CH64_2758 ENOG4105ESV Glycosyl transferase, family 4 CH64_2759 ENOG4105SFE lipopolysaccharide biosynthesis protein CH64_2760 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CH64_2761 ENOG4108IJ1 Dehydrogenase CH64_2762 ENOG4105C1B dTDP-glucose 4-6-dehydratase CH64_2763 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CH64_2764 ENOG4108WJ1 acetyltransferase CH64_2765 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CH64_2766 ENOG4105EGZ biosynthesis protein CH64_2767 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) CH64_277 ENOG4105RA2 Membrane CH64_2770 ENOG4105C85 amino acid CH64_2775 ENOG410601J HemY protein CH64_2776 ENOG4105ECF c-methyltransferase CH64_2777 ENOG41076E6 Uroporphyrinogen-III Synthase CH64_2778 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CH64_278 ENOG4105XVG cytoplasmic protein CH64_2782 ENOG4105S7Z (LipO)protein CH64_2783 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CH64_2784 ENOG4105CT0 Protein of unknown function, DUF484 CH64_2785 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CH64_2786 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant CH64_2787 ENOG4105C4R Atp-dependent dna helicase CH64_2789 ENOG4105EQN UPF0261 protein CH64_2792 ENOG4107QUT magnesium and cobalt transport protein CorA CH64_2793 ENOG4105FR1 rard protein CH64_2794 ENOG4108VUY thioesterase Superfamily protein CH64_2795 ENOG4105HDD phospholipase CH64_2796 ENOG4105C9U ATP-dependent DNA helicase RecQ CH64_2797 ENOG4105CCF Lysine exporter protein (Lyse ygga) CH64_2799 ENOG4108EUD Lysophospholipase CH64_28 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) CH64_280 ENOG4105WH1 Two component transcriptional regulator luxr family CH64_2800 ENOG4105DQF Hydrolase CH64_2801 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CH64_2802 ENOG4105CXY transporter CH64_2803 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A CH64_2804 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B CH64_2805 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CH64_2806 ENOG4108W1V Lipoprotein CH64_2807 ENOG4105EX9 Membrane CH64_2808 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) CH64_281 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CH64_2810 ENOG4107FS9 Membrane CH64_2813 ENOG4105MG3 Membrane CH64_2814 ENOG4106H78 methyltransferase CH64_2815 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CH64_2815 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CH64_2816 ENOG4105CAK Cell division ATP-binding protein ftsE CH64_2817 ENOG4105CRP Part of the ABC transporter FtsEX involved in CH64_2819 ENOG4105U59 -acetyltransferase CH64_282 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CH64_2821 ENOG4105CP9 extracellular ligand-binding receptor CH64_2822 ENOG4105C32 Amino acid ABC transporter (Permease) CH64_2823 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CH64_2824 ENOG4105C0Z ABC transporter CH64_2825 ENOG4108IV0 ABC, transporter CH64_2832 ENOG4105BZ7 extracellular solute-binding protein family 1 CH64_2833 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component CH64_2834 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CH64_2835 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH64_2836 ENOG4107T6V glycerophosphoryl diester phosphodiesterase CH64_2837 ENOG4105RK9 auxin efflux carrier CH64_2838 ENOG4105DZ2 Transcriptional regulator CH64_2839 ENOG4105EMK carboxylate amino acid amine transporter CH64_2840 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CH64_2841 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) CH64_2842 ENOG4108I5U Uridine phosphorylase CH64_2845 ENOG4108KF1 Membrane CH64_2846 ENOG4105CGY Dna recombination protein CH64_2847 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CH64_2848 ENOG4105JC1 sterol-binding domain protein CH64_2849 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) CH64_2850 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CH64_2851 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) CH64_2852 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CH64_2854 ENOG4105D52 delta-aminolevulinic acid dehydratase CH64_2855 ENOG4105MDZ Transcriptional activator rfaH CH64_2856 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CH64_2857 ENOG4107QK7 reductase CH64_2858 ENOG4105CHU acetyl-coa acetyltransferase CH64_2859 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CH64_2861 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CH64_2862 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) CH64_2863 ENOG4108RR8 protoporphyrinogen oxidase CH64_2869 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CH64_2870 ENOG4105CS9 pantothenic acid kinase CH64_2878 ENOG4105PM1 preprotein translocase subunit SecE CH64_2879 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CH64_2880 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CH64_2882 ENOG4108VZM 50s ribosomal protein L10 CH64_2883 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CH64_2884 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CH64_2885 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CH64_2886 ENOG4105D41 biosynthesis protein thiH CH64_2887 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CH64_2888 ENOG4105WHD thiamine biosynthesis protein ThiS CH64_2889 ENOG4105D06 uba thif-type nad fad binding protein CH64_2891 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CH64_2893 ENOG4105E09 nadh pyrophosphatase CH64_2894 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CH64_2895 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) CH64_2896 ENOG4105R2J Conserved Protein CH64_2898 ENOG4108T8B Protein of unknown function (DUF1481) CH64_2899 ENOG4105C12 Phosphoribosylglycinamide synthetase CH64_29 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CH64_2900 ENOG4105DC1 bifunctional purine biosynthesis protein purh CH64_2906 ENOG4107QN1 sodium solute CH64_2907 ENOG41062QD Membrane CH64_2908 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CH64_2909 ENOG4105CK2 sodium dicarboxylate symporter CH64_2910 ENOG4105WH1 Two component transcriptional regulator luxr family CH64_2911 ENOG4105BZU Histidine kinase CH64_2917 ENOG4105ZQI secreted protein CH64_2919 ENOG4108SZ7 secretion system effector CH64_2920 ENOG4106FZW pathogenicity island effector protein CH64_2931 ENOG4105UQF type iii secretion CH64_2934 ENOG4108JIR Flagellum-specific ATP synthase CH64_2938 ENOG4108HHI Type III secretion system protein CH64_2939 ENOG41083GP type iii secretion CH64_294 ENOG4105CHR reductase CH64_2940 ENOG4108TN6 type iii secretion CH64_2941 ENOG4108IUF type iii secretion CH64_2942 ENOG41066VF YeeE YedE family protein CH64_2943 ENOG4105KSU Redox protein CH64_2944 ENOG4105EGS Mechanosensitive ion channel CH64_2946 ENOG4105E0K tonB-dependent siderophore receptor CH64_2948 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CH64_2949 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CH64_2950 ENOG4105EHG Permease protein CH64_2951 ENOG4107R4I Periplasmic binding protein CH64_2952 ENOG4106QJH hemin transport protein CH64_2953 ENOG4107ENK receptor CH64_2954 ENOG4107F3C Hemin uptake protein CH64_2956 ENOG41090JE Utilization Protein CH64_2957 ENOG4105D4P Coproporphyrinogen iii oxidase CH64_2959 ENOG4105C6K Malic enzyme CH64_2962 ENOG4105FAW cDP-glucose 4,6-dehydratase CH64_2964 ENOG4105CKK Glycosyl transferase, family 2 CH64_2965 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CH64_2967 ENOG4105IQJ Involved in biosynthesis of the thiamine precursor thiazole (By similarity) CH64_2973 ENOG4108SIC Transcriptional regulator CH64_2974 ENOG4105BZW Glycerate kinase CH64_2975 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CH64_2977 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CH64_298 ENOG4108HCJ Hydrolase CH64_2980 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CH64_2981 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CH64_2982 ENOG4108ZVF (LipO)protein CH64_2983 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CH64_2984 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CH64_2986 ENOG4105KPY Small multidrug resistance protein CH64_2988 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) CH64_2989 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) CH64_299 ENOG4105WH1 Two component transcriptional regulator luxr family CH64_2993 ENOG4105EGS Mechanosensitive ion channel CH64_2994 ENOG4105DJ4 phosphatidylserine decarboxylase CH64_2995 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CH64_2996 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) CH64_300 ENOG4105DQQ Major facilitator superfamily MFS_1 CH64_3000 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CH64_3001 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CH64_3002 ENOG4105K8N protein family UPF0079, ATPase CH64_3003 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CH64_3004 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CH64_3005 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CH64_3006 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CH64_3007 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CH64_3008 ENOG4107QJR hflk protein CH64_3009 ENOG4105EPW hflc protein CH64_301 ENOG4105CRU nitrate reductase, alpha subunit CH64_3011 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CH64_3012 ENOG4105KPV Transcriptional regulator CH64_3013 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CH64_3014 ENOG4105C2N RNA methyltransferase TrmH family group 3 CH64_3015 ENOG4105CSU acyl-Coa dehydrogenase CH64_3016 ENOG4105WSB biofilm stress and motility protein A CH64_3017 ENOG4108MXZ Esterase CH64_3019 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CH64_302 ENOG4108IUE nitrate reductase beta subunit CH64_3020 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CH64_3021 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CH64_3023 ENOG4105FHY Opacity-associated protein A CH64_3024 ENOG4108V1T peptidylprolyl cis-trans isomerase CH64_3026 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic CH64_3027 ENOG4108UUE Transcriptional regulator CH64_3028 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase CH64_3029 ENOG41061GZ Protein of unknown function (DUF1107) CH64_303 ENOG4105R3A Nitrate reductase CH64_3030 ENOG4105C37 (CBS) domain CH64_3031 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CH64_3032 ENOG4105CFU surface antigen CH64_3034 ENOG4108ZHD aig2 family CH64_3035 ENOG4105F0N pyrophosphate phospho-hydrolase CH64_3036 ENOG4105C8Q Methyl-accepting chemotaxis CH64_3038 ENOG4105DFU Cell wall formation (By similarity) CH64_304 ENOG41076YT nitrate reductase, gamma subunit CH64_3042 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CH64_3043 ENOG4105HVQ Regulatory factor of maltose metabolism CH64_3045 ENOG4105EAH synthase CH64_3048 ENOG4105QYV Membrane CH64_3049 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CH64_305 ENOG4105C85 amino acid CH64_3052 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase CH64_3053 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CH64_3054 ENOG4105HBR Rna-binding protein CH64_3055 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) CH64_3056 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CH64_3057 ENOG4105EEI dihydropteroate synthase CH64_3062 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CH64_3063 ENOG4105CHV Transcription elongation factor NusA CH64_3064 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CH64_3065 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CH64_3066 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CH64_3068 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CH64_307 ENOG4108MRH transcriptional regulatory protein CH64_3070 ENOG4105C1J atp-dependent rna helicase CH64_3072 ENOG4105DEN Luciferase family CH64_3073 ENOG4106RZ4 Peptidase U32 CH64_3074 ENOG4105CFP Peptidase U32 CH64_3075 ENOG4105XPQ lipid carrier protein CH64_3076 ENOG4108YYD acetyltransferase CH64_3077 ENOG41082IR Excinuclease ABC C subunit domain protein CH64_3078 ENOG4105D5Q Arginine ornithine antiporter CH64_3079 ENOG4105CXN decarboxylase CH64_308 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CH64_3082 ENOG4105WEM extracellular solute-binding protein CH64_3083 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CH64_3084 ENOG4105DRS transport system, permease CH64_3087 ENOG4108ZPB UPF0306 protein CH64_3088 ENOG4105K4T epimerase CH64_3089 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) CH64_309 ENOG4105CSV Glutaminase CH64_3090 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CH64_3091 ENOG4108JQ7 (ABC) transporter CH64_3092 ENOG4105C3U ABC transporter CH64_3093 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CH64_3094 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CH64_3096 ENOG4105XEP YhcH YjgK YiaL family protein CH64_3098 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) CH64_31 ENOG4107GZ4 SanA protein CH64_3100 ENOG4108MJ3 acetyltransferase CH64_3102 ENOG4105MYG DNA polymerase iii, chi subunit CH64_3103 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CH64_3104 ENOG4108M8S permease YjgP YjgQ family protein CH64_3105 ENOG4108K5H permease YjgP YjgQ family protein CH64_3109 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) CH64_3110 ENOG4107IIZ CRISPR-associated helicase, Cas3 CH64_3111 ENOG4105ENG CRISPR-associated protein, Csy1 family CH64_3112 ENOG4105DZX CRISPR-associated protein, Csy2 family CH64_3113 ENOG4105M6W Crispr-associated protein, Csy3 family CH64_3114 ENOG4108Y1S CRISPR-associated protein, Csy4 family CH64_312 ENOG4107SJW iron permease, FTR1 CH64_3127 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CH64_3129 ENOG4108VEV chaperone CH64_3130 ENOG4105CW0 outer membrane usher protein CH64_3139 ENOG4105CS6 Rhs element vgr protein CH64_3147 ENOG4108WQH regulatoR CH64_3148 ENOG4105BZU Histidine kinase CH64_3149 ENOG4105TNG K13735 adhesin invasin CH64_315 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CH64_3150 ENOG4105EZE Cupin 4 family protein CH64_3155 ENOG4105RI1 glycoprotein receptor CH64_3156 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound CH64_3157 ENOG41061GT Aldolase CH64_3158 ENOG4105D4B ABC, transporter CH64_3159 ENOG4105F5R ABC transporter CH64_3160 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CH64_3161 ENOG4105C2J ABC transporter CH64_3162 ENOG4105DKT Transcriptional regulator CH64_3163 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) CH64_3164 ENOG4105DKP glycosyl transferase, family 9 CH64_3166 ENOG4105D5Q Arginine ornithine antiporter CH64_3167 ENOG4105CEU Arginine dihydrolase CH64_3168 ENOG410624X efflux transporter, rnd family, mfp subunit CH64_3169 ENOG4105BZS acriflavin resistance protein CH64_317 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CH64_3171 ENOG4105CMT Dihydroxyacetone kinase CH64_3172 ENOG4108UTZ Dihydroxyacetone kinase CH64_3173 ENOG4105VDH Dihydroxyacetone kinase CH64_3174 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CH64_3175 ENOG4105WBN Transcriptional regulator (LacI family CH64_3176 ENOG4108HKT sucrose-6-phosphate hydrolase CH64_3178 ENOG4108M0B Sucrose porin CH64_3179 ENOG4105D7K pfkb domain protein CH64_3180 ENOG4106TD9 Diguanylate cyclase CH64_3181 ENOG4105YBH Protein of unknown function (DUF1435) CH64_3185 ENOG4105CBN LysR family transcriptional regulator CH64_3186 ENOG4105CPC Aldo Keto reductase CH64_3187 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) CH64_3188 ENOG4108WPU DNA polymerase III subunit psi CH64_3189 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CH64_3190 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CH64_3192 ENOG4105K3G Periplasmic Protein CH64_3194 ENOG4108NRW Phospholipase, patatin family CH64_3196 ENOG4105EYA deoxyribonuclease CH64_3197 ENOG4105D9N nucleoside CH64_3198 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CH64_3199 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CH64_32 ENOG4107R1I NAD-dependent malic enzyme CH64_3200 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CH64_3202 ENOG41062Z9 Membrane CH64_3203 ENOG4105EAC phosphoserine phosphatase CH64_3204 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CH64_3205 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase CH64_3206 ENOG4105CIS alcohol dehydrogenase CH64_3208 ENOG4105C5H ABC transporter CH64_3209 ENOG4107R08 Integrase CH64_321 ENOG4108819 ferric iron reductase CH64_3211 ENOG41090EK ompa motb domain protein CH64_3212 ENOG4108KHX Diguanylate cyclase CH64_3213 ENOG4108WS1 CH64_3215 ENOG4107SC1 transglycosylase CH64_3216 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) CH64_3217 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CH64_3218 ENOG4105UEI Transcriptional Regulator AraC Family CH64_3219 ENOG4105CVJ phosphoglycerate mutase CH64_322 ENOG4105DC7 peptidase M24 CH64_3220 ENOG4108RH0 Crea protein CH64_3221 ENOG41065U4 response regulator CH64_3225 ENOG4105D1Q UPF0246 protein CH64_3226 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CH64_3227 ENOG4108RIR Molybdenum cofactor biosynthesis protein CH64_323 ENOG4108TUY outer membrane protein PgaA CH64_3230 ENOG4106HK8 GPR1 FUN34 yaaH family protein CH64_3232 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CH64_3233 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CH64_3234 ENOG41063Z6 transcriptional regulator, lysR family CH64_3236 ENOG4105DTN riboflavin biosynthesis protein ribF CH64_3237 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CH64_3238 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CH64_3239 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase CH64_324 ENOG4107BJW polysaccharide deacetylase CH64_3240 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CH64_3241 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CH64_3242 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CH64_3243 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CH64_3244 ENOG4105N14 lysine exporter protein LysE YggA CH64_3245 ENOG4105DWK Membrane CH64_3247 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CH64_3248 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CH64_3249 ENOG4105NWN ApaG protein CH64_325 ENOG4105CND Glycosyl transferase, family 2 CH64_3252 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) CH64_3253 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) CH64_3256 ENOG4105D3G Pseudouridine synthase CH64_3258 ENOG4105CQ2 DNA polymerase CH64_3259 ENOG4108KF1 Membrane CH64_3261 ENOG4106SMU thiamine transporter membrane protein CH64_3262 ENOG4105DP9 ABC transporter CH64_3263 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CH64_3264 ENOG4105F1A Pyruvate formate-lyase CH64_3265 ENOG4105C6N Formate acetyltransferase CH64_3266 ENOG4105S8Q sugar efflux transporter CH64_3271 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CH64_3272 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CH64_3273 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CH64_3274 ENOG41064T2 transcriptional regulator, lysR family CH64_3275 ENOG4108IQE Amp-dependent synthetase and ligase CH64_3276 ENOG4105C7K acetolactate synthase CH64_3277 ENOG4108ZP8 Acetolactate synthase small subunit CH64_3278 ENOG4107B7Y DNA-binding transcriptional regulator FruR CH64_3281 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CH64_3282 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CH64_3283 ENOG4105CJN penicillin-binding protein CH64_3284 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CH64_3285 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) CH64_3286 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CH64_3288 ENOG4105CNI cell division protein FtsW CH64_3289 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CH64_329 ENOG4105D5M phosphate starvation-inducible protein CH64_3290 ENOG4105DFU Cell wall formation (By similarity) CH64_3292 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) CH64_3293 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CH64_3294 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CH64_3297 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) CH64_3298 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CH64_3299 ENOG4105M6F mutator MutT protein CH64_330 ENOG4105EWV Sodium calcium exchanger membrane region CH64_3300 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) CH64_3302 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CH64_3303 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CH64_3306 ENOG4105D7Q type ii secretion system CH64_3307 ENOG4107QHF type ii secretion system protein e CH64_3308 ENOG4108ZUW Major pilin subunit CH64_3309 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CH64_3310 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CH64_3311 ENOG4106A72 regulatory protein AmpE CH64_3312 ENOG4105C85 amino acid CH64_3313 ENOG41073TP transcriptional regulator CH64_3314 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CH64_3315 ENOG4107QSN dihydrolipoamide acetyltransferase CH64_3316 ENOG4107QN2 dihydrolipoyl dehydrogenase CH64_3319 ENOG4107RNH Outer membrane receptor FepA CH64_332 ENOG4107R11 Transcriptional regulator CH64_3320 ENOG4107QIJ Aconitate hydratase 2 CH64_3321 ENOG4108ZIG UPF0231 protein CH64_3322 ENOG4105RPH Inner membrane protein YddG CH64_333 ENOG4105BZU Histidine kinase CH64_3331 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CH64_3332 ENOG4108ZRK uncharacterized protein yacC CH64_3333 ENOG4105E3B Multicopper oxidase CH64_3334 ENOG4108UGV hypoxanthine phosphoribosyltransferase CH64_3335 ENOG41077A9 carbonic anhydrase CH64_3336 ENOG4105DA5 (ABC) transporter CH64_3337 ENOG4105E3A (ABC) transporter CH64_3338 ENOG4107BJW polysaccharide deacetylase CH64_3339 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CH64_3341 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CH64_3342 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CH64_3343 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CH64_3344 ENOG4105DJ0 Poly(A) Polymerase CH64_3345 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) CH64_3346 ENOG4105BZ4 penicillin-binding protein CH64_3347 ENOG4105E0A ABC, transporter CH64_3348 ENOG4105J76 Periplasmic binding protein CH64_3349 ENOG4105S6R Iron-hydroxamate transporter permease subunit CH64_335 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CH64_3351 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CH64_3353 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CH64_3354 ENOG4105EN6 Membrane CH64_3356 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CH64_3357 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein CH64_3358 ENOG4105C0H protease CH64_3359 ENOG4105BZU Histidine kinase CH64_336 ENOG4105C4M (Ubiquinol oxidase) subunit I CH64_3360 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CH64_3361 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CH64_3362 ENOG4105DXN mazG family CH64_3363 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CH64_3368 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CH64_3369 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CH64_337 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CH64_3370 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CH64_3371 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CH64_3372 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CH64_3373 ENOG4108MXK alkaline phosphatase isozyme conversion CH64_3374 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CH64_3375 ENOG4105C11 sulfate adenylyltransferase), subunit 2 CH64_3376 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) CH64_3377 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CH64_3378 ENOG4105N0Z inner membrane protein ygbE CH64_338 ENOG4105C8Y Acetylornithine aminotransferase CH64_3380 ENOG4105E5Q amino acid AbC transporter CH64_3381 ENOG4105E89 ABC transporter CH64_3382 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CH64_3385 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) CH64_3386 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) CH64_3387 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CH64_3388 ENOG4108K5P (LipO)protein CH64_3389 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH64_339 ENOG4105F4X arginine CH64_3390 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CH64_3393 ENOG4108RQP Major type 1 subunit fimbrin CH64_3394 ENOG4106PG1 outer membrane usher protein CH64_3395 ENOG4108FZ9 Chaperone CH64_3397 ENOG4105NEV Fimbrial CH64_34 ENOG41067MG lrgb family CH64_3403 ENOG4108JJA ABC, transporter CH64_3404 ENOG4105DJY efflux transporter, rnd family, mfp subunit CH64_3405 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CH64_3406 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CH64_3407 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH64_341 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) CH64_3410 ENOG4105CHR reductase CH64_3411 ENOG4105E89 ABC transporter CH64_3413 ENOG4105W8I Transcriptional regulator CH64_3414 ENOG4105C6Z Gluconate CH64_3415 ENOG4105BZC d-serine deaminase CH64_3416 ENOG4105EAB amino acid AbC transporter CH64_3417 ENOG4105E5Q amino acid AbC transporter CH64_3418 ENOG4105E5Q amino acid AbC transporter CH64_3419 ENOG4105CDA abc transporter atp-binding protein CH64_342 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) CH64_3420 ENOG4105CE7 Amidase, hydantoinase carbamoylase family CH64_3421 ENOG4105EIG urea carboxylase-associated protein 1 CH64_3424 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CH64_3425 ENOG4105YVS arsR family transcriptional regulator CH64_3426 ENOG4107GFK fumarate CH64_3428 ENOG4107QY8 reductase CH64_3429 ENOG4105QAX Iron-sulfur CH64_3430 ENOG4107KGK dmso reductase anchor subunit CH64_3431 ENOG4108NEM leader-binding protein dmsD CH64_3434 ENOG4105C2J ABC transporter CH64_3435 ENOG4105CNN ABC, transporter CH64_3436 ENOG4108HHA Transketolase CH64_3437 ENOG4108IUS Transketolase CH64_3438 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CH64_3443 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CH64_3444 ENOG4105Y3E Modulates RecA activity (By similarity) CH64_3445 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CH64_3446 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CH64_345 ENOG4105CI2 imidazolone-5-propionate hydrolase CH64_3451 ENOG4107VXZ Hydrolase CH64_3452 ENOG4105W39 Membrane CH64_3453 ENOG4105D9M gamma-glutamylcysteine synthetase CH64_3454 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) CH64_3455 ENOG4108JU6 CBS domain protein CH64_3456 ENOG4106KVJ cytochrome C assembly protein CH64_3457 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CH64_3458 ENOG4105K5M 30s ribosomal protein S16 CH64_3459 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CH64_346 ENOG4105CZE histidine utilization repressor CH64_3460 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CH64_3461 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CH64_3462 ENOG4108NE3 Salt-induced outer membrane protein CH64_3463 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CH64_3464 ENOG4108NEV two component transcriptional regulator, LytTR family CH64_3465 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CH64_3467 ENOG4105CQC Prephenate dehydratase CH64_3468 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA CH64_3469 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CH64_347 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CH64_3470 ENOG4105C34 Pseudouridine synthase CH64_3471 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CH64_3472 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CH64_3478 ENOG4105T42 (LipO)protein CH64_3479 ENOG4105JIM Phosphatidylserine synthase CH64_3480 ENOG4105CD5 CoA-binding domain protein CH64_3481 ENOG4106IUH DTW domain containing protein CH64_3482 ENOG4105K63 Thioredoxin CH64_3483 ENOG4105EIB trna rrna methyltransferase CH64_3484 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH64_3485 ENOG4105CW7 secretion protein, HlyD family CH64_3486 ENOG4105NTK Transcriptional repressor Mpra CH64_3487 ENOG4105ZED uncharacterized protein ygaH CH64_3488 ENOG4108UMN azlc family CH64_3489 ENOG4105EQ0 Major Facilitator superfamily CH64_349 ENOG41090B9 response to stress CH64_3492 ENOG4105C5R Aminotransferase CH64_3494 ENOG4105CHM Aminotransferase CH64_3495 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CH64_3496 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) CH64_3497 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CH64_3499 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CH64_35 ENOG4105VAW lrga family CH64_3502 ENOG4106YJS accessory processing protein CH64_3503 ENOG4107QPN acyl-Coa dehydrogenase CH64_3505 ENOG4105F7V ErfK ybiS ycfS ynhG family protein CH64_3506 ENOG4105E7A Glutamine amidotransferase CH64_3507 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH64_3508 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH64_3509 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH64_351 ENOG4105C2J ABC transporter CH64_3510 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH64_3511 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH64_3512 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) CH64_3513 ENOG4105CJ2 (LipO)protein CH64_3515 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CH64_3516 ENOG4105CPF Cell wall formation (By similarity) CH64_3517 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CH64_3518 ENOG4105CIN aminoacyl-histidine dipeptidase CH64_352 ENOG4108HWV )-transporter CH64_3520 ENOG4105V1F Fermentation respiration switch protein CH64_3521 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) CH64_3522 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CH64_3523 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CH64_3527 ENOG4105F2W methyltransferase CH64_353 ENOG4108MEK Metal-binding protein YodA CH64_3530 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CH64_3532 ENOG4105DH7 May be involved in recombination (By similarity) CH64_3533 ENOG4105DKQ ROK family CH64_3534 ENOG4105EYH Exonuclease CH64_3535 ENOG4107RH8 nuclease SbcCD subunit D CH64_3536 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CH64_3537 ENOG4105BZU Histidine kinase CH64_3539 ENOG4105CWM branched-chain amino acid transport system II carrier protein CH64_3540 ENOG4105C85 amino acid CH64_3541 ENOG4107R28 alpha amylase, catalytic region CH64_3542 ENOG4105CHR reductase CH64_3544 ENOG41074AV Hok/gef family CH64_3545 ENOG4105D3R alkyl hydroperoxide reductase CH64_3546 ENOG4108ZYK Acyl carrier protein phosphodiesterase CH64_3547 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CH64_3548 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CH64_3549 ENOG4105VIE preprotein translocase, subunit YajC CH64_355 ENOG4108K5P (LipO)protein CH64_3550 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CH64_3551 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CH64_3553 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CH64_3554 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CH64_3556 ENOG4107YIM Involved in the transcription termination process (By similarity) CH64_3557 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CH64_3558 ENOG4108ZAI phosphatidylglycerophosphatase a CH64_3559 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CH64_356 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CH64_3560 ENOG4105CTB Polyprenyl synthetase CH64_3561 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CH64_3562 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CH64_3563 ENOG4107S0N DJ-1 family CH64_3564 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CH64_3565 ENOG4108VPT UPF0234 protein CH64_3566 ENOG4107RDB Major Facilitator CH64_3567 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CH64_3568 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) CH64_3569 ENOG4105CCU oxidase (Subunit III) CH64_357 ENOG4108HCJ Hydrolase CH64_3570 ENOG4105BZ9 Cytochrome C oxidase, subunit I CH64_3571 ENOG4105E2S oxidase) subunit II CH64_3572 ENOG4108NFH Sugar hydrolase CH64_3573 ENOG4105EYM Major Facilitator superfamily CH64_3574 ENOG4105IEY (LipO)protein CH64_3575 ENOG4105M85 Bola protein CH64_3576 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CH64_3579 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CH64_358 ENOG4105E98 transcriptional regulator DeoR family CH64_3580 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CH64_3581 ENOG4105K70 DNA-binding protein CH64_3582 ENOG4105EIN peptidylprolyl cis-trans isomerase CH64_3583 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein CH64_3584 ENOG4108TGP Thioesterase superfamily protein CH64_3585 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CH64_3586 ENOG4108NFA extracellular solute-binding protein CH64_3587 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) CH64_3589 ENOG4108XM1 transcriptional regulator AsnC family CH64_3590 ENOG4105BZ1 (ABC) transporter CH64_3591 ENOG4105BZ1 (ABC) transporter CH64_3592 ENOG4108YZA Nitrogen regulatory protein pii CH64_3593 ENOG4105BZU Histidine kinase CH64_3594 ENOG4105C29 acyl-CoA thioesterase CH64_3595 ENOG4108MNP Glycoprotein polysaccharide metabolism CH64_3596 ENOG41080UX Methyltransferase CH64_3597 ENOG4105KF5 hemolysin expression-modulating protein CH64_3598 ENOG4108UKR Biofilm formation regulator YbaJ CH64_36 ENOG4105E5W Transporter CH64_360 ENOG4108WQH regulatoR CH64_3600 ENOG4105DIK (ABC) transporter CH64_3601 ENOG4105CC5 ABC transporter CH64_3602 ENOG4105DSE periplasmic solute binding protein CH64_3603 ENOG4105YK5 50S ribosomal protein L36 CH64_3604 ENOG4105NRA 50s ribosomal protein l31 type b CH64_3605 ENOG4105BZS acriflavin resistance protein CH64_3606 ENOG4105C1P efflux transporter, rnd family, mfp subunit CH64_3607 ENOG4108IG5 Transcriptional regulator CH64_3608 ENOG41090EX DsrE family CH64_3609 ENOG4105EGS Mechanosensitive ion channel CH64_361 ENOG4105CVK Glutamate decarboxylase CH64_3610 ENOG4106428 Protein of unknown function (DUF2496) CH64_3612 ENOG4105WD1 Membrane CH64_3613 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CH64_3614 ENOG4107QMP dna polymerase iii subunits gamma and tau CH64_3616 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CH64_3617 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CH64_3618 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CH64_3619 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CH64_362 ENOG4105E5D amino acid CH64_3620 ENOG4105ER6 polysaccharide biosynthesis protein CH64_3621 ENOG4108SHN Glycosyl transferase, family 2 CH64_3622 ENOG4105CG5 Glycosyl transferase (Group 1 CH64_3624 ENOG4105ESV Glycosyl transferase, family 4 CH64_3627 ENOG4105CMR udp-glucose 4-epimerase CH64_3628 ENOG4107RE1 Inosine-guanosine kinase CH64_3629 ENOG4105CKD glutathione-regulated potassium-efflux system protein CH64_363 ENOG4105C3G gtp-binding protein CH64_3630 ENOG4105EU0 Major facilitator Superfamily CH64_3631 ENOG4105CGH 5'-nucleotidase CH64_3632 ENOG4108Z66 YbaK ebsC protein CH64_3633 ENOG4105MBR gumn family CH64_3634 ENOG4105C59 p-type ATPase CH64_3635 ENOG4108Z6Z Transcriptional regulator CH64_3636 ENOG4105G5H Membrane CH64_3637 ENOG4107QX8 SPFH domain, Band 7 family protein CH64_3638 ENOG4107QR8 Thioredoxin CH64_3639 ENOG4105E1F short-chain dehydrogenase reductase CH64_3640 ENOG4108UJV acyl-CoA thioesterase i CH64_3641 ENOG4108I0Y (ABC) transporter CH64_3642 ENOG4105CV6 ABC transporter, permease CH64_3643 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CH64_3644 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CH64_3645 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) CH64_3646 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CH64_3647 ENOG4105C8N cysteinyl-tRNA synthetase CH64_3648 ENOG4105WQ3 Rna-binding protein CH64_3649 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CH64_365 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CH64_3651 ENOG4105DFP Integrase CH64_366 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria CH64_3663 ENOG4108MXD gtp-binding protein CH64_3666 ENOG4106H6R UPF0380 protein CH64_3667 ENOG4106549 Antirestriction protein CH64_3669 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles CH64_3671 ENOG4108KU3 Integrase CH64_3672 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin CH64_3676 ENOG4105UZW Tail fiber assembly protein CH64_368 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CH64_3684 ENOG4108KU3 Integrase CH64_3690 ENOG4105CMM transposase CH64_3695 ENOG4105CKT filamentous hemagglutinin CH64_3696 ENOG4105D5K Hemolysin activator protein CH64_3699 ENOG4108JJ7 ABC transporter CH64_370 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) CH64_3703 ENOG4108R1E Serine threonine protein phosphatase 1 CH64_3705 ENOG4108N8T regulatoR CH64_3707 ENOG4105VEQ Cold shock protein CH64_3708 ENOG4107Z6W Protein CrcB homolog CH64_3709 ENOG4105BZU Histidine kinase CH64_371 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CH64_3710 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) CH64_3711 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CH64_3712 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CH64_3713 ENOG4108Z43 UPF0250 protein CH64_3714 ENOG4105DZ1 carboxypeptidase CH64_3715 ENOG4105K6T rare lipoprotein A CH64_3716 ENOG4105CNI cell division protein FtsW CH64_3717 ENOG4105CJN penicillin-binding protein CH64_3719 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) CH64_3720 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CH64_3721 ENOG4105DJF DNA polymerase III, delta' subunit CH64_3722 ENOG4108U2H Rare lipoprotein B CH64_3723 ENOG4105C8T Leucyl-tRNA synthetase CH64_3724 ENOG4107PAI alpha helical protein CH64_3725 ENOG4105CDA abc transporter atp-binding protein CH64_3726 ENOG4105DRP amino acid AbC transporter CH64_3727 ENOG4105EAD ABC transporter CH64_3728 ENOG4107RP9 extracellular solute-binding protein, family 3 CH64_373 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CH64_3730 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CH64_3731 ENOG4108JU5 Magnesium and cobalt efflux protein CH64_3732 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CH64_3733 ENOG4105C9A Phoh family CH64_3734 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CH64_3735 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CH64_374 ENOG4108YY7 Invasion gene expression up-regulator SirB CH64_3743 ENOG4105CAQ asparagine synthetase CH64_3744 ENOG4105D4U had-superfamily hydrolase, subfamily iia CH64_3745 ENOG4105E2R ROK family CH64_3746 ENOG4105CE4 GlcNAc 6-P deacetylase CH64_3748 ENOG4105CI1 PTS System CH64_3749 ENOG4105CX6 glutaminyL-tRNA synthetase CH64_375 ENOG41063JG Transcriptional regulator CH64_3751 ENOG4105GX6 (LipO)protein CH64_3753 ENOG41090R7 Ferric uptake CH64_3755 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) CH64_3756 ENOG4105C8Q Methyl-accepting chemotaxis CH64_3757 ENOG4105NNH LexA regulated protein CH64_3758 ENOG4105EV9 Alpha Beta Hydrolase CH64_3760 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 CH64_3764 ENOG4105EEX Two component transcriptional regulator (Winged helix family CH64_3766 ENOG4105C08 Histidine kinase CH64_3767 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CH64_3768 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CH64_377 ENOG4105CHH sulfate transporter CH64_3770 ENOG4105XIQ Protein of unknown function (DUF2517) CH64_3771 ENOG4107SEY Conserved Protein CH64_3772 ENOG4105CVP deoxyribo-dipyrimidine photolyase CH64_3773 ENOG4107RF4 Phosphodiesterase CH64_3774 ENOG4107QNR UPF0135 protein CH64_3775 ENOG4105P4J Allophanate hydrolase, subunit 1 CH64_3776 ENOG4107R7A Allophanate hydrolase subunit 2 CH64_3777 ENOG4105E7W lamb ycsf family protein CH64_378 ENOG4105BZU Histidine kinase CH64_3781 ENOG4105BZN citrate synthase CH64_3782 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit CH64_3783 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein CH64_3784 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) CH64_3785 ENOG4105E33 succinate dehydrogenase CH64_3786 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CH64_3787 ENOG4105C7S Dehydrogenase CH64_3789 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CH64_3790 ENOG4105CGH 5'-nucleotidase CH64_3791 ENOG4105C4M (Ubiquinol oxidase) subunit I CH64_3792 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CH64_3794 ENOG4105KJB cyd operon protein YbgE CH64_3795 ENOG4107YD3 Thioesterase CH64_3796 ENOG4105E02 MotA TolQ exbB proton channel CH64_3797 ENOG4105M8F Biopolymer transport protein exbD tolR CH64_3798 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA CH64_3798 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA CH64_3799 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) CH64_3800 ENOG4105KCK Peptidoglycan-associated lipoprotein CH64_3801 ENOG4105UFD tol-pal system protein YbgF CH64_3807 ENOG4106Z1T Nicotinamide Mononucleotide Transporter CH64_3808 ENOG4105PGM cation diffusion facilitator family transporter CH64_3809 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CH64_3810 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CH64_3812 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CH64_3813 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CH64_3814 ENOG4105F0Z galactose-1-phosphate uridylyltransferase CH64_3815 ENOG4105CMR udp-glucose 4-epimerase CH64_3817 ENOG4105DKW ABC transporter CH64_3818 ENOG4105F4R Transcriptional regulator mode CH64_3819 ENOG410680R Protein of unknown function (DUF2592) CH64_382 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase CH64_3820 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CH64_3821 ENOG4105E0C molybdate abc transporter CH64_3823 ENOG4108K4B hydrolase CH64_3824 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CH64_3826 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CH64_3827 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CH64_3828 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CH64_3829 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CH64_3831 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CH64_3832 ENOG4105VYA Uncharacterized conserved protein (DUF2132) CH64_3833 ENOG4105CHW UPF0052 protein CH64_3834 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CH64_3835 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CH64_3836 ENOG4105M00 molybdopterin converting factor, subunit 1 CH64_3837 ENOG4108ZAF Molybdopterin CH64_3838 ENOG4105HFZ Membrane CH64_3839 ENOG4107QWP ABC-2 type transporter CH64_384 ENOG4107XHZ cytoplasmic chaperone TorD family protein CH64_3840 ENOG4107QWP ABC-2 type transporter CH64_3841 ENOG4105CJ1 ABC, transporter CH64_3842 ENOG4105D0S secretion protein (HlyD CH64_3843 ENOG4107MVR Transcriptional regulator CH64_3844 ENOG4105C1J atp-dependent rna helicase CH64_3845 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) CH64_3846 ENOG4105CJW magnesium transporter CH64_3848 ENOG41061WM D-Alanyl-D-Alanine CH64_3849 ENOG4105CXG d-lactate dehydrogenase CH64_385 ENOG4105F3T (LipO)protein CH64_3851 ENOG4105N1F Hnh endonuclease CH64_3853 ENOG4105Y3U Transglycosylase-associated protein CH64_3854 ENOG4108W15 Protein of unknown function (DUF1456) CH64_3856 ENOG4105C32 Amino acid ABC transporter (Permease) CH64_3857 ENOG4105CNN ABC, transporter CH64_3858 ENOG4105C0Z ABC transporter CH64_3859 ENOG4108IV0 ABC, transporter CH64_386 ENOG4105EV4 Multidrug resistance protein mdtH CH64_3860 ENOG4105KHC sulfurtransferase CH64_3863 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system CH64_3864 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component CH64_3865 ENOG4108IJ8 ABC transporter CH64_3866 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component CH64_3868 ENOG4105FDR Membrane CH64_387 ENOG4105D9U N-acetyltransferase CH64_3870 ENOG4105DVT helicase CH64_3871 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CH64_3872 ENOG4108MTB glycosyl transferase family CH64_3876 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) CH64_3877 ENOG4107SDU Methyl-accepting chemotaxis CH64_3878 ENOG4105CDA abc transporter atp-binding protein CH64_3879 ENOG4105E5Q amino acid AbC transporter CH64_3880 ENOG4107R0W ABC transporter CH64_3881 ENOG4105KSC Transcriptional regulator, TraR DksA family CH64_3882 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction CH64_3883 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) CH64_3886 ENOG4108T1M outer membrane protein x CH64_389 ENOG4105EP9 oxidoreductase CH64_3890 ENOG4105C5H ABC transporter CH64_3891 ENOG4105D06 uba thif-type nad fad binding protein CH64_3892 ENOG4105CVM Molybdenum cofactor synthesis domain protein CH64_3895 ENOG4105C19 ABC transporter CH64_390 ENOG4105CJR Integral membrane protein (MviN CH64_391 ENOG4105C75 arginyL-tRNA synthetase CH64_392 ENOG4106ZCM YecM protein CH64_393 ENOG4106N3A copper homeostasis protein cutc CH64_396 ENOG4105WJG Glutathione CH64_397 ENOG41081XQ Conserved Protein CH64_398 ENOG4105D3W isochorismatase CH64_399 ENOG4105C9M aspartyl-trna synthetase CH64_40 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CH64_400 ENOG4108TIT dATP pyrophosphohydrolase CH64_401 ENOG4105CDY transcriptional regulatory protein CH64_403 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CH64_404 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CH64_405 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CH64_406 ENOG4105DUX Transporter CH64_407 ENOG4105FAV ABC, transporter CH64_408 ENOG4105FDK ABC transporter CH64_409 ENOG4105NXV High-affinity zinc uptake system protein CH64_41 ENOG4105D1F ATP-binding protein CH64_410 ENOG4105DR5 peptidase CH64_411 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase CH64_412 ENOG4105CA9 Pyruvate kinase CH64_413 ENOG4106KNT transcriptional regulator CH64_414 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CH64_415 ENOG4108UHU Aldolase CH64_416 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) CH64_418 ENOG4105M4H endoribonuclease L-psp CH64_419 ENOG4105DVT helicase CH64_420 ENOG41072GX Peptidase M22 Glycoprotease CH64_421 ENOG4105Y4Z Outer Membrane Lipoprotein CH64_422 ENOG4105CEY Amp-dependent synthetase and ligase CH64_423 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) CH64_424 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) CH64_425 ENOG4107QMS site-determining protein CH64_426 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CH64_428 ENOG4105VNG YcgL domain-containing protein CH64_429 ENOG4105CVE Lytic murein transglycosylase CH64_43 ENOG4105DBI uridine monophosphokinase CH64_430 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase CH64_431 ENOG4108ZZ3 UPF0260 protein CH64_434 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CH64_435 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) CH64_436 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CH64_437 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) CH64_438 ENOG4105ED1 spovr family CH64_439 ENOG4105MWK D-amino acid dehydrogenase, small subunit CH64_44 ENOG4105DHP deoxycytidine triphosphate deaminase CH64_440 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CH64_441 ENOG4105CNH Multidrug resistance protein MdtL CH64_442 ENOG4105BZU Histidine kinase CH64_443 ENOG4105EUB pirin domain protein CH64_444 ENOG4105HEI LysR family (Transcriptional regulator CH64_446 ENOG4106AKX UPF0229 protein CH64_447 ENOG4105CYN Serine protein kinase CH64_448 ENOG4105GNX MltA-interacting MipA family protein CH64_449 ENOG4105DSB aldose 1-epimerase CH64_45 ENOG4108GAE asmA family CH64_452 ENOG4105VUT cytoplasmic protein CH64_453 ENOG4108RWI nicotinamidase CH64_454 ENOG4105HDK L-asparaginase CH64_455 ENOG4105D07 Signal peptide peptidase, SppA CH64_456 ENOG41069NU Nitroreductase CH64_458 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CH64_459 ENOG4105M6F mutator MutT protein CH64_46 ENOG4105CEE C4-dicarboxylate transporter CH64_460 ENOG4105MTM Protein of unknown function (DUF1496) CH64_461 ENOG4105CGK Exodeoxyribonuclease III CH64_462 ENOG4105SKE transcriptional Regulator LysR family CH64_466 ENOG4105CIY formyltetrahydrofolate deformylase CH64_467 ENOG4105K5B UPF0225 protein CH64_468 ENOG4108MJ3 acetyltransferase CH64_469 ENOG4105D78 K07001 NTE family protein CH64_47 ENOG4105EE5 Membrane protein terC CH64_470 ENOG4105I93 response regulator CH64_472 ENOG4107104 thymidine kinase CH64_473 ENOG4108EKI Dehydrogenase CH64_475 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CH64_476 ENOG4107QSI ABC, transporter CH64_477 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CH64_478 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CH64_479 ENOG4105C3U ABC transporter CH64_480 ENOG4108JQ7 (ABC) transporter CH64_482 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CH64_483 ENOG4105CMB EAL domain-containing protein CH64_485 ENOG4105K9H YciI-like protein CH64_486 ENOG410822N TonB family CH64_487 ENOG4105NAU thioesterase Superfamily protein CH64_488 ENOG4107835 probably involved in intracellular septation (By similarity) CH64_490 ENOG4108S3I UPF0259 membrane protein CH64_491 ENOG4105EIF outer membrane protein W CH64_495 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CH64_496 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CH64_497 ENOG4105DK0 Indole-3-glycerol phosphate synthase CH64_499 ENOG4105DDQ anthranilate synthase CH64_5 ENOG4105EGI Transcriptional regulator CH64_504 ENOG4105FE9 pseudouridine synthase CH64_506 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CH64_507 ENOG4105UBK short-chain dehydrogenase reductase CH64_508 ENOG4105ERU peptidase CH64_509 ENOG4105RKX Protein of unknown function (DUF2498) CH64_51 ENOG4105EY8 ABC transporter CH64_510 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CH64_511 ENOG4107R11 Transcriptional regulator CH64_515 ENOG4107QM5 aconitate hydratase CH64_516 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) CH64_517 ENOG4105EYK Phosphatidylglycerophosphatase B CH64_518 ENOG4105Q4A inner membrane protein yciS CH64_519 ENOG4105CFV Tetratricopeptide repeat protein CH64_52 ENOG4108KQJ Type 11 methyltransferase CH64_521 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction CH64_522 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CH64_523 ENOG4108ZJT translation initiation factor, Sui1 CH64_524 ENOG41061RM osmotically inducible lipoprotein CH64_525 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase CH64_527 ENOG4105N2W Transcriptional regulator CH64_528 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CH64_529 ENOG4105VCD cytoplasmic protein CH64_530 ENOG4105D22 carbon starvation protein CH64_531 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) CH64_532 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit CH64_533 ENOG4105CSM endonuclease III CH64_535 ENOG4108UQQ Electron transport complex CH64_536 ENOG4105D6A Electron transport complex CH64_537 ENOG4105UEI Transcriptional Regulator AraC Family CH64_54 ENOG4105C0K Gdp-mannose 4,6-dehydratase CH64_540 ENOG4105DGN Electron transport complex CH64_541 ENOG4105M9B inner membrane protein ydgK CH64_542 ENOG4105CKU formyltetrahydrofolate synthetase CH64_544 ENOG4108JJA ABC, transporter CH64_546 ENOG4108JJA ABC, transporter CH64_549 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator CH64_55 ENOG4108DMA Nad-dependent epimerase dehydratase CH64_551 ENOG4105CNN ABC, transporter CH64_553 ENOG4105D9R oxidoreductase CH64_554 ENOG4105DHU Bile acid CH64_555 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CH64_556 ENOG4105C87 Aminotransferase class I and II CH64_557 ENOG4105CI1 PTS System CH64_558 ENOG4107P2S Transcriptional regulator CH64_559 ENOG4106J39 exported protein CH64_560 ENOG4105EIP mannose-6-phosphate isomerase CH64_561 ENOG4105C9Q fumarate hydratase class II CH64_562 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) CH64_565 ENOG4105D94 Major Facilitator Superfamily CH64_566 ENOG4106NZI LysR family Transcriptional regulator CH64_567 ENOG4105DAG ROK family CH64_568 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CH64_570 ENOG4105KBG Protein of unknown function (DUF1161) CH64_571 ENOG4105M5Q UPF0482 protein CH64_575 ENOG4105KK4 UPF0060 membrane protein CH64_576 ENOG4105EMU Dehydrogenase CH64_577 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH64_578 ENOG4105TDT uncharacterized protein yahO CH64_58 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CH64_580 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CH64_588 ENOG4105CYM Glutathione S-transferase CH64_59 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CH64_590 ENOG4108RYR transcriptional regulator AsnC family CH64_592 ENOG4105DSP amino acid AbC transporter CH64_593 ENOG4105E89 ABC transporter CH64_594 ENOG4106V2I dimethylaminohydrolase CH64_595 ENOG4105FYV Amp nucleosidase CH64_599 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CH64_6 ENOG4105CBP Major Facilitator CH64_60 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CH64_601 ENOG4105C7K acetolactate synthase CH64_602 ENOG4105M71 acetolactate synthase 1 regulatory subunit CH64_604 ENOG4105PAD Hydrolase CH64_606 ENOG4105ETT transcriptional Regulator, LysR family CH64_609 ENOG4105EDR glucose galactose transporter CH64_61 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CH64_610 ENOG4108RVA ribokinase CH64_613 ENOG4108VCD Chaperone CH64_614 ENOG4105CW0 outer membrane usher protein CH64_617 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) CH64_619 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CH64_62 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CH64_620 ENOG4105DS0 Transcriptional regulator, Crp Fnr family CH64_621 ENOG4105Q9Y Universal stress protein CH64_622 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CH64_623 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CH64_624 ENOG4105C5D exported protein CH64_625 ENOG4105D5Q Arginine ornithine antiporter CH64_627 ENOG4107EXC regulatoR CH64_628 ENOG4105JJR Histidine kinase CH64_629 ENOG4105CTD carboxy-peptidase CH64_63 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CH64_630 ENOG4105CHH sulfate transporter CH64_632 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap CH64_634 ENOG4105MRD Phage derived protein Gp49-like (DUF891) CH64_635 ENOG4105CQ7 ATP-dependent helicase CH64_636 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CH64_637 ENOG4105WXT Conserved Protein CH64_638 ENOG410689M (LipO)protein CH64_639 ENOG4107H52 Dicarboxylate transport CH64_64 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CH64_641 ENOG4105C5I Dehydrogenase CH64_642 ENOG41090X5 Heat shock protein hslJ CH64_644 ENOG4105KT7 mgtC SapB transporter CH64_646 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) CH64_65 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CH64_650 ENOG4107QSI ABC, transporter CH64_652 ENOG4107S8C mandelate racemase muconate lactonizing CH64_653 ENOG4105KXI murein peptide amidase A CH64_654 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CH64_658 ENOG4106K28 UPF0283 membrane protein CH64_659 ENOG4105CM6 amino acid regulated cytosolic protein CH64_66 ENOG4105CIH Imidazole acetol-phosphate transaminase CH64_661 ENOG4105FM1 phage shock protein C CH64_662 ENOG4105YYT phage shock protein B CH64_663 ENOG41087YS Phage shock protein A CH64_664 ENOG4105E51 psp operon transcriptional activator CH64_665 ENOG4108HIY periplasmic CH64_666 ENOG4108I5W peptide transport system, permease protein CH64_667 ENOG4108EU3 peptide transport system, permease CH64_668 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein CH64_669 ENOG4108JQ2 peptide transport system atp-binding protein CH64_67 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CH64_670 ENOG4105Q4T oxidoreductase CH64_671 ENOG4105DUM transcriptional regulator, lysR family CH64_672 ENOG4105DUX Transporter CH64_675 ENOG41069YE inner membrane protein yohC CH64_676 ENOG4108ZR5 Conserved Protein CH64_677 ENOG4108K3A Glutathione S-transferase CH64_679 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CH64_68 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CH64_681 ENOG410642K Lysozyme inhibitor CH64_682 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CH64_683 ENOG4108XTF Outer Membrane Lipoprotein CH64_684 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) CH64_686 ENOG4105Y49 secretion protein, HlyD family CH64_687 ENOG4105DSW Fusaric acid resistance protein CH64_688 ENOG4107RGM aldo keto reductase CH64_689 ENOG4105XZD Fe-S protein CH64_69 ENOG4108535 NAD dependent epimerase/dehydratase family CH64_690 ENOG4105DIJ Phosphoethanolamine transferase CH64_691 ENOG4108WUH Transcriptional regulator, TetR family CH64_692 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CH64_693 ENOG4108UYE Lactoylglutathione lyase CH64_694 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) CH64_695 ENOG4105M2J Glutaredoxin CH64_697 ENOG4105K4H Nlp p60 protein CH64_698 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CH64_7 ENOG4105EUJ GTP cyclohydrolase i CH64_70 ENOG4105CNN ABC, transporter CH64_700 ENOG4105ETE Transcriptional regulator (LacI family CH64_701 ENOG4105F52 Transcriptional regulator CH64_702 ENOG4105CZQ inner membrane transport protein YdhC CH64_703 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CH64_704 ENOG4108R6K riboflavin synthase, subunit alpha CH64_705 ENOG4107QI1 Mate efflux family protein CH64_71 ENOG4105C2J ABC transporter CH64_710 ENOG4105CA9 Pyruvate kinase CH64_711 ENOG4105KMX major outer membrane lipoprotein CH64_712 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CH64_715 ENOG4105JRK feS assembly protein SufD CH64_716 ENOG4105C3K feS assembly ATPase SufC CH64_717 ENOG4105DIW FeS assembly protein SUFB CH64_718 ENOG4108Z4V iron-sulfur cluster assembly CH64_719 ENOG4105KA0 thioesterase Superfamily protein CH64_72 ENOG4107SCQ Iron-containing alcohol dehydrogenase CH64_721 ENOG4105CQB FAD linked oxidase domain protein CH64_722 ENOG4105IPI Membrane CH64_723 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CH64_724 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CH64_725 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CH64_726 ENOG4107ENK receptor CH64_727 ENOG4106QJH hemin transport protein CH64_728 ENOG4107R4I Periplasmic binding protein CH64_730 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) CH64_731 ENOG4108QBX (LipO)protein CH64_732 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CH64_733 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CH64_734 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) CH64_737 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CH64_738 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) CH64_739 ENOG4108V06 Glutathione peroxidase CH64_74 ENOG4105CUB amino acid CH64_740 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) CH64_743 ENOG4105D3G Pseudouridine synthase CH64_744 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme CH64_745 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CH64_749 ENOG41082NX 50s ribosomal protein l35 CH64_75 ENOG4105CJB Exodeoxyribonuclease I CH64_750 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CH64_751 ENOG4105C22 threonyL-tRNA synthetase CH64_753 ENOG41087WU CH64_754 ENOG4108UQV Membrane CH64_758 ENOG41082NP Multiple antibiotic resistance CH64_759 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division CH64_760 ENOG4105DSE periplasmic solute binding protein CH64_761 ENOG4105DIK (ABC) transporter CH64_762 ENOG4105CC5 ABC transporter CH64_763 ENOG4105CC5 ABC transporter CH64_764 ENOG4105FGM Fructosamine kinase CH64_765 ENOG4105D5P Methylmalonyl-coA mutase CH64_766 ENOG4105DJT lAO AO transport system ATPase CH64_767 ENOG4108M7F enoyl-CoA hydratase isomerase CH64_768 ENOG4105DEQ transcriptional regulator CH64_769 ENOG4105CYC Transferase CH64_77 ENOG4105DR8 Membrane CH64_770 ENOG4107PN8 YfeABCD locus regulator CH64_771 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 CH64_772 ENOG4105M5J Cupin 2, conserved barrel domain protein CH64_773 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) CH64_774 ENOG4105CHR reductase CH64_775 ENOG41061NF Pectate lyase CH64_776 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CH64_777 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CH64_778 ENOG4108IJ9 (ABC) transporter CH64_779 ENOG4105WEM extracellular solute-binding protein CH64_78 ENOG41090HJ UPF0265 protein CH64_780 ENOG4108PU9 oligogalacturonate-specific porin CH64_781 ENOG4107K5X Membrane-bound metal-dependent hydrolase CH64_782 ENOG4108ETY sodium dicarboxylate symporter CH64_783 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CH64_785 ENOG4105CAZ oligogalacturonide lyase CH64_786 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH64_788 ENOG4105D0M Protease HtpX homolog CH64_789 ENOG4105CN1 protease CH64_792 ENOG4108ZGC gaf domain protein CH64_793 ENOG4105H2K paraquat-inducible protein a CH64_794 ENOG4105DY2 Paraquat-inducible protein b CH64_796 ENOG4105WT8 Protein of unknown function (DUF1480) CH64_8 ENOG4105DHF Membrane CH64_80 ENOG4105CNN ABC, transporter CH64_801 ENOG4108SHQ Glutathione S-transferase CH64_804 ENOG4105D6U Sodium Glutamate Symporter CH64_81 ENOG4105C2J ABC transporter CH64_82 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CH64_820 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CH64_821 ENOG4105CR4 methylisocitrate lyase CH64_824 ENOG4105KUS lysozyme CH64_828 ENOG4105RWQ Protein of unknown function (DUF1364) CH64_83 ENOG4107QZB decarboxylase CH64_830 ENOG4105NKT exported protein CH64_831 ENOG4108PNC copper resistance CH64_832 ENOG4105FXM Copper resistance protein CH64_833 ENOG41090A1 ferritin CH64_834 ENOG4105MPK DNA polymerase III subunit theta CH64_836 ENOG4105UMD exodeoxyribonuclease X CH64_837 ENOG4105CUG Oligopeptidase b CH64_839 ENOG4105N5Z UPF0267 protein CH64_840 ENOG4105X2V dna damage-inducible protein CH64_841 ENOG4105C1J atp-dependent rna helicase CH64_842 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CH64_843 ENOG4105X5C UPF0181 protein CH64_845 ENOG4105P8F nudix hydrolase CH64_846 ENOG4105EJQ L-serine dehydratase CH64_847 ENOG4105EE5 Membrane protein terC CH64_848 ENOG4108EQA pts system CH64_849 ENOG4105ETZ PTS System CH64_85 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CH64_850 ENOG4105F3R pts system mannose fructose sorbose family iid CH64_852 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) CH64_855 ENOG4105DHI Methyltransferase CH64_856 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CH64_857 ENOG4105VEQ Cold shock protein CH64_858 ENOG410610J Protein of unknown function (DUF2627) CH64_859 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) CH64_86 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CH64_860 ENOG4105C85 amino acid CH64_863 ENOG41064PC CH64_864 ENOG4105TIK CH64_865 ENOG4105N4N Protein of unknown function (DUF2766) CH64_87 ENOG41081F0 Precorrin-8x methylmutase CH64_870 ENOG4105D5Q Arginine ornithine antiporter CH64_872 ENOG4105BZ1 (ABC) transporter CH64_874 ENOG4105CTX dehydratase CH64_875 ENOG4105CSP Major Facilitator Superfamily CH64_876 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CH64_879 ENOG4105XXV Acid-resistance protein CH64_88 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) CH64_880 ENOG4105VTN Protein of unknown function (DUF1311) CH64_881 ENOG4107XVH Transcriptional regulator CH64_882 ENOG4105DWP Membrane CH64_884 ENOG4105KVH Transcriptional regulator CH64_885 ENOG4105ECR NmrA family CH64_886 ENOG4108IQK o-acetylhomoserine CH64_887 ENOG4105EFX secretion protein, HlyD family CH64_888 ENOG4105KK7 inner membrane protein YiaW CH64_889 ENOG4108KKZ (LipO)protein CH64_89 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase CH64_890 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor CH64_892 ENOG4106NDP Transcriptional regulator CH64_893 ENOG4108HKT sucrose-6-phosphate hydrolase CH64_894 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) CH64_898 ENOG4108HMX isocitrate dehydrogenase (NADP) CH64_899 ENOG4108R99 pseudouridine synthase CH64_9 ENOG41060NJ transcriptional regulator CH64_90 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase CH64_901 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CH64_902 ENOG41075W9 High frequency lysogenization protein HflD homolog CH64_903 ENOG4107QTF adenylosuccinate lyase CH64_904 ENOG4105XJC Two component transcriptional regulator (Winged helix family CH64_906 ENOG4105EZE Cupin 4 family protein CH64_908 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CH64_909 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) CH64_91 ENOG4105CIA precorrin-4 C(11)-methyltransferase CH64_910 ENOG4105D60 lipoprotein releasing system transmembrane protein CH64_912 ENOG4105D60 lipoprotein releasing system transmembrane protein CH64_913 ENOG4108JA2 transcriptioN-repair coupling factor CH64_914 ENOG4107MBR 17 kDa surface antigen CH64_915 ENOG4105CEP NADH dehydrogenase CH64_917 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) CH64_919 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) CH64_92 ENOG4108P62 biosynthesis protein (CbiG) CH64_920 ENOG41090DQ Lipoprotein CH64_921 ENOG4105K59 histidine triad (HIT) protein CH64_922 ENOG4105F9E Shikimate 5-dehydrogenase CH64_924 ENOG4105CI1 PTS System CH64_925 ENOG4105F8V Hydrolase, tatD family CH64_926 ENOG4107QRG dna polymerase iii CH64_927 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CH64_928 ENOG4105HHA aminodeoxychorismate lyase CH64_929 ENOG4105YAZ 4-amino-4-deoxychorismate lyase CH64_93 ENOG4105E4R Precorrin-3B C17-methyltransferase CH64_930 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH64_932 ENOG4105CHR reductase CH64_933 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CH64_935 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CH64_936 ENOG4105VGS 50s ribosomal protein l32 CH64_937 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein CH64_939 ENOG4105EI2 Pseudouridine synthase CH64_94 ENOG4105QUC reductase CH64_941 ENOG4107QQB Ribonuclease E CH64_941 ENOG4107QQB Ribonuclease E CH64_942 ENOG41067V3 Antibiotic biosynthesis monooxygenase CH64_943 ENOG4105EKE dihydroorotase CH64_945 ENOG4105PVA Biofilm formation regulatory protein BssS CH64_948 ENOG4105DSF transport protein CH64_949 ENOG4105C72 UPF0176 protein CH64_95 ENOG4107PPM cobalt chelatase CH64_951 ENOG4105DB1 molybdopterin oxidoreductase CH64_952 ENOG4106WHD Tetrathionate reductase CH64_953 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CH64_954 ENOG4106AFQ Histidine kinase CH64_955 ENOG4108ZXC Two component transcriptional regulator, luxr family CH64_956 ENOG4105D1S lipid A biosynthesis CH64_957 ENOG4105MGM doxx family CH64_958 ENOG4105C6X Major Facilitator CH64_959 ENOG4105DUX Transporter CH64_96 ENOG4105DVK Precorrin-2 c20-methyltransferase CH64_961 ENOG4105NAC (LipO)protein CH64_962 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) CH64_963 ENOG4105DJ9 glucan biosynthesis protein CH64_966 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) CH64_967 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase CH64_969 ENOG4105VJY transcriptional regulator CH64_97 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CH64_970 ENOG4107YC3 synthase CH64_971 ENOG4108W0S formate-dependent nitrite reductase complex CH64_972 ENOG4108DMF Cytochrome C biogenesis protein CH64_973 ENOG4107QX9 Thiol disulfide interChange protein CH64_974 ENOG4105DA4 cytochrome c-type biogenesis protein CH64_975 ENOG4105DVI reductase, NrfD CH64_976 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CH64_977 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit CH64_978 ENOG4105EAU Plays a role in nitrite reduction (By similarity) CH64_98 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CH64_981 ENOG4108Z0T Part of a sulfur-relay system (By similarity) CH64_982 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 CH64_983 ENOG4105DR4 Methyltransferase CH64_984 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) CH64_985 ENOG4105K4P CoA-binding domain protein CH64_987 ENOG4108Z5K methylglyoxal synthase CH64_988 ENOG41088T4 Helicase IV CH64_989 ENOG410901E Membrane CH64_99 ENOG4108V4M Cobalt abc transporter CH64_990 ENOG4105EM2 membrane CH64_991 ENOG4108RZ1 DNA transformation protein CH64_992 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) CH64_993 ENOG4105UYK outer membrane protein a CH64_994 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) CH64_995 ENOG4105DAN ATP-dependent protease CH64_996 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) CH64_998 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH64_999 ENOG4108Q2G (LipO)protein