locus-tag	class	description
CH64_1000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH64_1000	COG3008	intermembrane lipid transfer
CH64_1001	COG2995	paraquat-inducible protein a
CH64_1002	COG0488	(ABC) transporter
CH64_1003	COG0116	Belongs to the methyltransferase superfamily
CH64_1003	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH64_1004	COG3217	Mosc domain protein beta barrel domain protein
CH64_1004	COG0633	Ferredoxin
CH64_1006	COG0167	dihydroorotate dehydrogenase activity
CH64_1007	COG0308	aminopeptidase N
CH64_1008	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CH64_1009	COG0017	Asparaginyl-tRNA synthetase
CH64_101	COG1492	cobalamin metabolic process
CH64_1011	COG1448	Aminotransferase
CH64_1012	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH64_1013	COG3108	Peptidase M15
CH64_1014	COG2989	Protein conserved in bacteria
CH64_1015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CH64_1016	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CH64_1017	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH64_1020	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CH64_1021	COG3173	Aminoglycoside phosphotransferase
CH64_1023	COG2835	tetraacyldisaccharide 4'-kinase activity
CH64_1024	COG1278	Cold shock
CH64_1025	COG1278	Cold shock
CH64_1026	COG5383	Protein conserved in bacteria
CH64_1027	COG1663	tetraacyldisaccharide 4'-kinase activity
CH64_1029	COG2333	competence protein COMEC
CH64_1029	COG0658	competence protein
CH64_1030	COG0776	regulation of translation
CH64_1031	COG0539	negative regulation of cytoplasmic translation
CH64_1032	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CH64_1033	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CH64_1034	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CH64_1035	COG2323	membrane
CH64_1036	COG0252	asparaginase activity
CH64_1037	COG1944	ATP diphosphatase activity
CH64_1038	COG2116	formate transmembrane transporter activity
CH64_1039	COG1882	Formate acetyltransferase
CH64_1040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH64_1041	COG2814	Major facilitator Superfamily
CH64_1042	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CH64_1043	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH64_1044	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CH64_1045	COG3107	peptidoglycan biosynthetic process
CH64_1045	COG1674	ftsk spoiiie
CH64_1047	COG0492	ferredoxin-NADP+ reductase activity
CH64_1049	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH64_105	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CH64_1051	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH64_1052	COG0542	response to heat
CH64_1053	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CH64_1054	COG1278	Cold shock
CH64_1056	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_1057	COG2990	Protein conserved in bacteria
CH64_1058	COG3593	DNA synthesis involved in DNA repair
CH64_1059	COG2431	L-lysine efflux transmembrane transporter activity
CH64_1060	COG1151	hydroxylamine reductase activity
CH64_1061	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH64_1062	COG0028	Belongs to the TPP enzyme family
CH64_1064	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH64_1065	COG0702	epimerase
CH64_1066	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH64_1068	COG1126	abc transporter atp-binding protein
CH64_1069	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_107	COG0534	Mate efflux family protein
CH64_1070	COG4215	(ABC) transporter
CH64_1071	COG4160	amino acid transport
CH64_1072	COG2271	Major facilitator Superfamily
CH64_1073	COG2186	Transcriptional regulator
CH64_1077	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_1078	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH64_108	COG0835	chemotaxis
CH64_108	COG0784	Response regulator, receiver
CH64_1080	COG1177	transmembrane transport
CH64_1081	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH64_1082	COG3842	ATPase activity
CH64_1083	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH64_1086	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH64_1087	COG2985	domain, Protein
CH64_1087	COG0569	domain protein
CH64_1098	COG0671	phosphoesterase, PA-phosphatase related
CH64_1099	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH64_110	COG3311	Transcriptional regulator
CH64_1100	COG1349	DNA-binding transcription factor activity
CH64_1101	COG0814	amino acid
CH64_1102	COG1760	l-serine dehydratase
CH64_1103	COG1686	Belongs to the peptidase S11 family
CH64_1105	COG0626	cystathionine gamma-synthase activity
CH64_1106	COG2011	ABC-type metal ion transport system permease component
CH64_1112	COG0625	glutathione transferase activity
CH64_1113	COG4771	TonB-dependent receptor
CH64_1114	COG0833	amino acid
CH64_1115	COG0583	DNA-binding transcription factor activity
CH64_1116	COG2855	membrane
CH64_1117	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CH64_1118	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH64_1118	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH64_1118	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH64_1119	COG1105	Belongs to the carbohydrate kinase PfkB family
CH64_1124	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH64_1125	COG1312	Catalyzes the dehydration of D-mannonate
CH64_1126	COG0246	Mannitol dehydrogenase
CH64_1127	COG2186	Transcriptional regulator
CH64_1129	COG0523	cobalamin synthesis protein
CH64_1130	COG0671	phosphoesterase, PA-phosphatase related
CH64_1131	COG0791	NLP P60 protein
CH64_1132	COG2200	EAL domain
CH64_1133	COG4166	transmembrane transport
CH64_1134	COG4174	ABC transporter (Permease)
CH64_1135	COG4239	(ABC) transporter, permease
CH64_1136	COG4172	Belongs to the ABC transporter superfamily
CH64_1139	COG2814	Major facilitator Superfamily
CH64_1140	COG1187	pseudouridine synthase activity
CH64_1141	COG1061	Type III restriction enzyme res subunit
CH64_1143	COG3081	Nucleoid-associated protein
CH64_1144	COG3082	Protein of unknown function (DUF1414)
CH64_1147	COG2723	6-phospho-beta-galactosidase activity
CH64_1148	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_1148	COG2190	(PTS) system
CH64_1148	COG1263	PTS System
CH64_1149	COG1737	Transcriptional regulator
CH64_1155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH64_1158	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH64_1159	COG2223	nitrite transmembrane transporter activity
CH64_1160	COG2198	Histidine kinase
CH64_1160	COG0642	Histidine kinase
CH64_1162	COG2205	protein histidine kinase activity
CH64_1162	COG0784	Response regulator, receiver
CH64_1164	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH64_1165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH64_1167	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH64_1168	COG4574	serine-type endopeptidase inhibitor activity
CH64_1170	COG0814	amino acid
CH64_1174	COG1441	menaquinone biosynthetic process
CH64_1175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH64_1177	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CH64_1178	COG1169	isochorismate synthase
CH64_1180	COG4575	ribosome binding
CH64_1181	COG0129	dihydroxy-acid dehydratase activity
CH64_1182	COG4702	Belongs to the UPF0303 family
CH64_1184	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH64_1185	COG1609	Transcriptional regulator
CH64_1186	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_1187	COG3265	gluconokinase activity
CH64_1188	COG2731	YhcH YjgK YiaL family protein
CH64_1191	COG1007	ATP synthesis coupled electron transport
CH64_1192	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_1193	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH64_1194	COG0713	ATP synthesis coupled electron transport
CH64_1195	COG0839	Belongs to the complex I subunit 6 family
CH64_1196	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_1197	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CH64_1198	COG1034	ATP synthesis coupled electron transport
CH64_1200	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CH64_1201	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_1201	COG0649	NAD binding
CH64_1202	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_1203	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_1204	COG0583	DNA-binding transcription factor activity
CH64_1205	COG0436	Aminotransferase
CH64_1206	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CH64_1207	COG0471	metal ion transport
CH64_1207	COG0490	domain, Protein
CH64_1209	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH64_1210	COG3013	Belongs to the UPF0304 family
CH64_1211	COG3092	negative regulation of chromosome organization
CH64_1213	COG0280	phosphate acetyltransferase
CH64_1213	COG0857	belongs to the CobB CobQ family
CH64_1214	COG1609	Transcriptional regulator
CH64_1215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_1217	COG3037	sugar-specific permease SgaT UlaA
CH64_1218	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH64_1219	COG0622	Phosphoesterase
CH64_1221	COG1090	epimerase
CH64_1222	COG4598	ABC transporter
CH64_1223	COG4160	amino acid transport
CH64_1224	COG4215	(ABC) transporter
CH64_1225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_1226	COG0163	prenyltransferase activity
CH64_1227	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH64_1228	COG1286	toxin biosynthetic process
CH64_1229	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH64_1230	COG0285	dihydrofolate synthase activity
CH64_1231	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CH64_1232	COG0586	Pfam SNARE associated Golgi protein
CH64_1234	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH64_1235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH64_1237	COG0697	spore germination
CH64_1239	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH64_1240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH64_1245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH64_1249	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH64_125	COG1204	response to ionizing radiation
CH64_1250	COG2723	6-phospho-beta-galactosidase activity
CH64_1251	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH64_1253	COG1794	racemase activity, acting on amino acids and derivatives
CH64_1254	COG3706	GGDEF domain
CH64_1254	COG0745	RESPONSE REGULATOR receiver
CH64_1255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH64_1256	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CH64_1256	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH64_1258	COG3101	peptidyl-lysine hydroxylation
CH64_1259	COG0730	response to heat
CH64_1260	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH64_1261	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CH64_1262	COG2890	protein-(glutamine-N5) methyltransferase activity
CH64_1263	COG2840	Smr protein MutS2
CH64_1264	COG2062	phosphohistidine phosphatase, SixA
CH64_1265	COG1024	Enoyl-CoA hydratase
CH64_1265	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH64_1266	COG0183	Belongs to the thiolase family
CH64_1267	COG3691	Protein conserved in bacteria
CH64_1270	COG3088	subunit of a heme lyase
CH64_1270	COG4235	cytochrome complex assembly
CH64_1271	COG3088	subunit of a heme lyase
CH64_1271	COG4235	cytochrome complex assembly
CH64_1272	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH64_1273	COG1138	Cytochrome C-type biogenesis protein
CH64_1274	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CH64_1275	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH64_1276	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH64_1277	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH64_1279	COG2116	formate transmembrane transporter activity
CH64_1281	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CH64_1282	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH64_1284	COG4948	Mandelate Racemase Muconate Lactonizing
CH64_1285	COG0800	Aldolase
CH64_1286	COG3734	2-keto-3-deoxy-galactonokinase
CH64_1287	COG2186	Transcriptional regulator
CH64_1288	COG2824	Alkylphosphonate utilization operon protein PhnA
CH64_1289	COG1695	Transcriptional regulator
CH64_1291	COG2723	6-phospho-beta-galactosidase activity
CH64_1292	COG1263	PTS System
CH64_1292	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_1294	COG0583	DNA-binding transcription factor activity
CH64_1295	COG2197	response regulator
CH64_1296	COG1609	Transcriptional regulator
CH64_1297	COG2353	YceI-like domain
CH64_1298	COG3038	cytochrome b561
CH64_1301	COG1127	ABC transporter
CH64_1302	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH64_1306	COG0531	amino acid
CH64_1307	COG2951	lytic endotransglycosylase activity
CH64_1312	COG0243	molybdopterin cofactor binding
CH64_1313	COG0437	4 iron, 4 sulfur cluster binding
CH64_1314	COG3302	dmso reductase anchor subunit
CH64_1315	COG3381	protein complex oligomerization
CH64_1317	COG3038	cytochrome b561
CH64_1318	COG0436	Aminotransferase
CH64_1319	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH64_1321	COG3275	phosphorelay sensor kinase activity
CH64_1322	COG3279	Response regulator of the LytR AlgR family
CH64_1323	COG2223	nitrite transmembrane transporter activity
CH64_1324	COG0837	glucose binding
CH64_1327	COG3961	Belongs to the TPP enzyme family
CH64_1328	COG0667	Aldo Keto reductase
CH64_1330	COG1914	H( )-stimulated, divalent metal cation uptake system
CH64_1331	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH64_1332	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CH64_1333	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH64_1333	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH64_1334	COG0583	DNA-binding transcription factor activity
CH64_1335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH64_1335	COG1648	precorrin-2 dehydrogenase activity
CH64_1337	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH64_1339	COG4865	methylaspartate mutase activity
CH64_1340	COG3799	methylaspartate ammonia-lyase activity
CH64_1343	COG1301	dicarboxylic acid transport
CH64_1349	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH64_1354	COG3530	Putative quorum-sensing-regulated virulence factor
CH64_1358	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CH64_1359	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_1361	COG2190	(PTS) system
CH64_1362	COG2205	protein histidine kinase activity
CH64_1363	COG0745	RESPONSE REGULATOR receiver
CH64_1364	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_1368	COG4208	sulfate ABC transporter
CH64_1369	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH64_1370	COG4150	thiosulfate binding
CH64_1372	COG1737	Transcriptional regulator
CH64_1373	COG2731	YhcH YjgK YiaL family protein
CH64_1376	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH64_1377	COG2837	iron assimilation
CH64_1379	COG3111	PFAM Bacterial OB fold (BOF) protein
CH64_1380	COG0456	acetyltransferase
CH64_1381	COG0408	coproporphyrinogen oxidase activity
CH64_1384	COG0494	nUDIX hydrolase
CH64_1387	COG3005	denitrification pathway
CH64_1389	COG3043	anaerobic respiration
CH64_139	COG0582	viral genome integration into host DNA
CH64_1390	COG0243	molybdopterin cofactor binding
CH64_1391	COG3062	negative regulation of establishment of protein localization
CH64_1392	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH64_1394	COG2197	response regulator
CH64_1396	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH64_1398	COG1393	Belongs to the ArsC family
CH64_1399	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH64_14	COG2116	formate transmembrane transporter activity
CH64_1400	COG1876	peptidase activity
CH64_1402	COG0400	carboxylic ester hydrolase activity
CH64_1403	COG1444	tRNA N-acetyltransferase activity
CH64_1404	COG2707	UPF0756 membrane protein
CH64_1405	COG2321	neutral zinc metallopeptidase
CH64_1406	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CH64_1407	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH64_1408	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH64_1409	COG2716	regulation of RNA biosynthetic process
CH64_1410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH64_1411	COG0628	permease
CH64_1412	COG4783	chaperone-mediated protein folding
CH64_1413	COG1393	Belongs to the ArsC family
CH64_1414	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH64_1415	COG2233	PERMEase
CH64_1416	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CH64_1418	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH64_1419	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH64_1423	COG0581	inorganic phosphate transmembrane transporter activity
CH64_1424	COG0573	inorganic phosphate transmembrane transporter activity
CH64_1425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH64_1426	COG0248	Ppx GppA phosphatase
CH64_1428	COG2239	Acts as a magnesium transporter
CH64_1429	COG3447	MASE1 domain protein
CH64_1429	COG5002	protein histidine kinase activity
CH64_1429	COG5001	Diguanylate cyclase
CH64_1430	COG0443	Heat shock 70 kDa protein
CH64_1431	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_1433	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH64_1435	COG0477	Major facilitator Superfamily
CH64_1436	COG2205	protein histidine kinase activity
CH64_1437	COG0745	RESPONSE REGULATOR receiver
CH64_1438	COG3422	double-strand break repair
CH64_144	COG3121	Chaperone
CH64_1440	COG1597	lipid kinase activity
CH64_1441	COG3730	PTS system glucitol sorbitol-specific
CH64_1444	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_1445	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_1446	COG1349	DNA-binding transcription factor activity
CH64_1450	COG0351	phosphomethylpyrimidine kinase
CH64_1453	COG0519	Catalyzes the synthesis of GMP from XMP
CH64_1453	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CH64_1454	COG0517	IMP dehydrogenase activity
CH64_1454	COG0516	GMP reductase activity
CH64_1455	COG1570	exodeoxyribonuclease VII activity
CH64_1456	COG1645	bacterial-type flagellum-dependent swarming motility
CH64_1458	COG1160	GTP binding
CH64_1459	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH64_1460	COG2976	Protein conserved in bacteria
CH64_1461	COG0124	histidyl-tRNA synthetase
CH64_1462	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CH64_1463	COG1426	Protein conserved in bacteria
CH64_1465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CH64_1467	COG4953	penicillin-binding protein 1C
CH64_1468	COG2373	Large extracellular alpha-helical protein
CH64_147	COG3121	Chaperone
CH64_1470	COG0243	molybdopterin cofactor binding
CH64_1471	COG3468	outer membrane autotransporter barrel domain protein
CH64_1473	COG3468	outer membrane autotransporter barrel domain protein
CH64_1476	COG2975	iron-sulfur cluster assembly
CH64_1477	COG0633	Ferredoxin
CH64_1478	COG0443	Heat shock 70 kDa protein
CH64_1479	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH64_1481	COG0822	iron-sulfur transferase activity
CH64_1482	COG1104	cysteine desulfurase activity
CH64_1483	COG1959	2 iron, 2 sulfur cluster binding
CH64_1484	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CH64_1485	COG0483	inositol monophosphate 1-phosphatase activity
CH64_1486	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH64_1487	COG3683	transport system, periplasmic component
CH64_1488	COG2814	Major facilitator Superfamily
CH64_1489	COG3711	transcriptional antiterminator
CH64_149	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_149	COG2205	protein histidine kinase activity
CH64_1490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CH64_1491	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH64_1491	COG1017	nitric oxide dioxygenase activity
CH64_1492	COG2188	Transcriptional regulator
CH64_1493	COG0347	Belongs to the P(II) protein family
CH64_1494	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH64_1494	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH64_1495	COG2204	response regulator
CH64_1496	COG3170	Tfp pilus assembly protein FimV
CH64_1497	COG2205	protein histidine kinase activity
CH64_1500	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CH64_1501	COG0590	tRNA wobble adenosine to inosine editing
CH64_1502	COG0560	Phosphoserine phosphatase
CH64_1504	COG1737	Transcriptional regulator
CH64_1505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH64_1506	COG2610	gluconate transmembrane transporter activity
CH64_1507	COG0736	holo-[acyl-carrier-protein] synthase activity
CH64_1508	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH64_1509	COG1381	Involved in DNA repair and RecF pathway recombination
CH64_1510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CH64_1512	COG0681	Belongs to the peptidase S26 family
CH64_1513	COG0481	GTPase activity
CH64_1515	COG3086	response to oxidative stress
CH64_1516	COG3026	antisigma factor binding
CH64_1517	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH64_1519	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH64_1520	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CH64_1521	COG0513	Belongs to the DEAD box helicase family
CH64_1523	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CH64_1524	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CH64_1525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CH64_1526	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH64_1527	COG0497	DNA recombination
CH64_1528	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH64_1530	COG2867	negative regulation of translational initiation
CH64_1531	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CH64_1532	COG0582	viral genome integration into host DNA
CH64_1534	COG3311	Transcriptional regulator
CH64_1537	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CH64_1542	COG0210	DNA helicase
CH64_1550	COG3596	GTP binding
CH64_1551	COG2378	regulation of single-species biofilm formation
CH64_1555	COG2003	Belongs to the UPF0758 family
CH64_1564	COG3394	polysaccharide catabolic process
CH64_1565	COG2169	Transcriptional regulator
CH64_1565	COG1917	Cupin 2, conserved barrel domain protein
CH64_1566	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH64_1567	COG2723	6-phospho-beta-galactosidase activity
CH64_1568	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH64_1569	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH64_157	COG3842	ATPase activity
CH64_1570	COG2133	pyrroloquinoline quinone binding
CH64_1571	COG0667	Aldo Keto reductase
CH64_1573	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH64_1574	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH64_1576	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH64_1577	COG4413	Urea transporter
CH64_1578	COG0829	nickel cation binding
CH64_1579	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH64_1580	COG0830	nickel cation binding
CH64_1582	COG0804	urea catabolic process
CH64_1583	COG0832	Belongs to the urease beta subunit family
CH64_1588	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH64_159	COG1840	ABC-type Fe3 transport system, periplasmic component
CH64_1593	COG1278	Cold shock
CH64_1597	COG0477	Major facilitator Superfamily
CH64_1599	COG4575	ribosome binding
CH64_16	COG3383	formate dehydrogenase (NAD+) activity
CH64_160	COG2271	Major facilitator Superfamily
CH64_1601	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH64_1603	COG1780	Probably involved in ribonucleotide reductase function
CH64_1605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH64_1606	COG4175	Glycine betaine
CH64_1607	COG4176	ABC-type proline glycine betaine transport system permease component
CH64_1608	COG2113	Glycine betaine
CH64_1610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH64_1612	COG2226	methyltransferase
CH64_1613	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH64_1614	COG1388	LysM domain
CH64_1614	COG0741	lytic transglycosylase activity
CH64_1615	COG3021	interspecies interaction between organisms
CH64_1616	COG2814	Major facilitator Superfamily
CH64_1617	COG0583	DNA-binding transcription factor activity
CH64_1618	COG0656	L-ascorbic acid biosynthetic process
CH64_1620	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_1627	COG1215	transferase activity, transferring glycosyl groups
CH64_163	COG4565	transcriptional regulatory protein
CH64_1631	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CH64_1632	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CH64_164	COG3290	protein histidine kinase activity
CH64_1642	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH64_1644	COG2011	ABC-type metal ion transport system permease component
CH64_1645	COG1464	Belongs to the NlpA lipoprotein family
CH64_1647	COG1720	tRNA m6t6A37 methyltransferase activity
CH64_1648	COG0442	prolyl-tRNA aminoacylation
CH64_1649	COG3015	lipoprotein NlpE involved in copper resistance
CH64_165	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CH64_1651	COG4681	YaeQ
CH64_1653	COG4568	rho-dependent transcription termination
CH64_1655	COG0037	tRNA processing
CH64_1656	COG0346	lactoylglutathione lyase activity
CH64_1657	COG0825	malonyl-CoA metabolic process
CH64_1658	COG0587	DNA-directed DNA polymerase activity
CH64_1659	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CH64_166	COG3052	prosthetic group binding
CH64_1660	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH64_1661	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH64_1662	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH64_1664	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH64_1666	COG0750	zinc metalloprotease
CH64_1667	COG0575	Belongs to the CDS family
CH64_1668	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CH64_1669	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CH64_167	COG2301	Belongs to the HpcH HpaI aldolase family
CH64_1670	COG0233	cytoplasmic translational termination
CH64_1671	COG0528	UMP kinase activity
CH64_1673	COG0052	Belongs to the universal ribosomal protein uS2 family
CH64_1674	COG0024	Methionine aminopeptidase
CH64_1675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CH64_1676	COG2171	N-acyltransferase activity
CH64_1679	COG0564	pseudouridine synthase activity
CH64_168	COG3051	citrate lyase alpha subunit
CH64_1680	COG3098	single-species biofilm formation
CH64_1682	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH64_1682	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH64_1683	COG1611	Belongs to the LOG family
CH64_1684	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH64_1685	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CH64_1686	COG2363	Small membrane protein
CH64_1687	COG0583	DNA-binding transcription factor activity
CH64_1689	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH64_1690	COG2166	iron-sulfur cluster assembly
CH64_1691	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH64_1692	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH64_1696	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH64_1697	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH64_1697	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CH64_1698	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH64_1699	COG1074	ATP-dependent DNA helicase activity
CH64_17	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH64_1700	COG1025	Belongs to the peptidase M16 family
CH64_1701	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH64_1707	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CH64_1709	COG1051	belongs to the nudix hydrolase family
CH64_171	COG0471	metal ion transport
CH64_1710	COG3066	DNA modification
CH64_1711	COG0861	Integral membrane protein TerC family
CH64_1712	COG0667	Aldo Keto reductase
CH64_1713	COG0477	Major facilitator Superfamily
CH64_1714	COG0204	Acyl-transferase
CH64_1714	COG0318	PFAM AMP-dependent synthetase and ligase
CH64_1716	COG1609	Transcriptional regulator
CH64_1717	COG0019	diaminopimelate decarboxylase activity
CH64_1718	COG0583	DNA-binding transcription factor activity
CH64_1719	COG2814	Major facilitator Superfamily
CH64_1720	COG0583	DNA-binding transcription factor activity
CH64_1725	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CH64_1731	COG2165	general secretion pathway protein
CH64_1732	COG2165	general secretion pathway protein
CH64_1738	COG0288	reversible hydration of carbon dioxide
CH64_174	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH64_1740	COG0484	heat shock protein binding
CH64_1741	COG1609	Transcriptional regulator
CH64_1742	COG2271	Major facilitator Superfamily
CH64_1745	COG1522	sequence-specific DNA binding
CH64_1746	COG3706	GGDEF domain
CH64_175	COG2977	Belongs to the P-Pant transferase superfamily
CH64_1750	COG1470	cell adhesion involved in biofilm formation
CH64_1750	COG1388	LysM domain
CH64_1754	COG2197	response regulator
CH64_1755	COG0791	NLP P60 protein
CH64_1756	COG2963	transposase activity
CH64_1759	COG3188	usher protein
CH64_1769	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CH64_1770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH64_1772	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH64_1773	COG4974	Belongs to the 'phage' integrase family
CH64_1774	COG0716	FMN binding
CH64_1776	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CH64_1777	COG0354	folic acid binding
CH64_1779	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CH64_1783	COG1272	protein, Hemolysin III
CH64_1784	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_1785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH64_1785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH64_1787	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CH64_1788	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH64_1789	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH64_1790	COG0006	proline dipeptidase activity
CH64_1791	COG3079	Belongs to the UPF0149 family
CH64_1792	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CH64_1793	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH64_1794	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH64_1795	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH64_1796	COG0583	DNA-binding transcription factor activity
CH64_1798	COG1279	arginine transmembrane transporter activity
CH64_18	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH64_180	COG3228	Belongs to the MtfA family
CH64_1801	COG0191	fructose-bisphosphate aldolase activity
CH64_1803	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH64_1804	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH64_1805	COG0501	Belongs to the peptidase M48B family
CH64_1806	COG2146	nitrite reductase [NAD(P)H] activity
CH64_1807	COG1166	arginine decarboxylase activity
CH64_1811	COG0640	Transcriptional regulator
CH64_1812	COG3091	SprT-like family
CH64_1813	COG2356	endonuclease I
CH64_1814	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH64_1815	COG0189	ligase activity
CH64_1817	COG1678	Uncharacterized ACR, COG1678
CH64_1818	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CH64_1819	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH64_182	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH64_1821	COG2805	Type II/IV secretion system protein
CH64_1822	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH64_1823	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH64_1824	COG0762	integral membrane protein
CH64_1825	COG1872	DUF167
CH64_1826	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH64_1827	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH64_1829	COG2066	Belongs to the glutaminase family
CH64_1830	COG3171	Protein conserved in bacteria
CH64_1831	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CH64_1832	COG1194	a g-specific adenine glycosylase
CH64_1834	COG0741	lytic transglycosylase activity
CH64_1835	COG1982	Orn Lys Arg decarboxylase major
CH64_1837	COG0582	viral genome integration into host DNA
CH64_1838	COG0582	viral genome integration into host DNA
CH64_1841	COG0791	NLP P60 protein
CH64_1843	COG3316	Transposase and inactivated derivatives
CH64_1849	COG3210	domain, Protein
CH64_1852	COG3210	domain, Protein
CH64_1853	COG3210	domain, Protein
CH64_1858	COG3210	domain, Protein
CH64_1862	COG3210	domain, Protein
CH64_1863	COG2831	hemolysin activation secretion protein
CH64_1867	COG1012	belongs to the aldehyde dehydrogenase family
CH64_1868	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CH64_1869	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_1872	COG2271	Major facilitator Superfamily
CH64_1875	COG1414	Transcriptional regulator
CH64_1879	COG2146	nitrite reductase [NAD(P)H] activity
CH64_188	COG3321	synthase
CH64_188	COG0604	alcohol dehydrogenase
CH64_188	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_189	COG3250	beta-galactosidase activity
CH64_1892	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CH64_190	COG1609	Transcriptional regulator
CH64_191	COG1278	Cold shock
CH64_1911	COG0642	Histidine kinase
CH64_1912	COG3477	response to acidic pH
CH64_1913	COG1609	Transcriptional regulator
CH64_1915	COG2211	Major facilitator Superfamily
CH64_1918	COG1289	transmembrane transporter activity
CH64_1923	COG0024	Methionine aminopeptidase
CH64_1924	COG4604	ABC transporter, ATP-binding protein
CH64_1925	COG4605	iron ion homeostasis
CH64_1927	COG4607	ABC-type enterochelin transport system periplasmic component
CH64_1929	COG0477	Major facilitator Superfamily
CH64_193	COG0840	transmembrane signaling receptor activity
CH64_1930	COG1609	Transcriptional regulator
CH64_1932	COG1283	sodium-dependent phosphate transmembrane transporter activity
CH64_1937	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_1938	COG5001	Diguanylate cyclase
CH64_1939	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CH64_194	COG1285	pathogenesis
CH64_1941	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CH64_1942	COG0309	Hydrogenase expression formation protein (HypE)
CH64_1943	COG0409	Hydrogenase expression formation protein
CH64_1944	COG0298	carbon dioxide binding
CH64_1945	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH64_1946	COG0375	protein maturation
CH64_1947	COG1773	rubredoxin
CH64_1948	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH64_1949	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CH64_1950	COG5557	Pfam Polysulphide reductase, NrfD
CH64_1951	COG0437	4 iron, 4 sulfur cluster binding
CH64_1952	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CH64_1953	COG3133	Outer membrane lipoprotein
CH64_1955	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CH64_1956	COG1191	sigma factor activity
CH64_196	COG2130	NADP-dependent
CH64_1961	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CH64_1962	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH64_1963	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH64_1964	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH64_1968	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH64_197	COG0589	response to stress
CH64_1971	COG1706	bacterial-type flagellum-dependent cell motility
CH64_1973	COG4786	Flagellar basal body rod
CH64_1975	COG1749	Flagellar hook protein flgE
CH64_1976	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH64_1977	COG1558	bacterial-type flagellum-dependent cell motility
CH64_1988	COG2204	response regulator
CH64_1992	COG1987	bacterial-type flagellum assembly
CH64_1994	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH64_1997	COG0840	transmembrane signaling receptor activity
CH64_1998	COG4592	Periplasmic binding protein
CH64_1999	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH64_20	COG3260	NADH ubiquinone oxidoreductase 20
CH64_2000	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH64_2001	COG1120	ATPase activity
CH64_2006	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_2007	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH64_2012	COG4964	Belongs to the GSP D family
CH64_202	COG1360	Flagellar Motor Protein
CH64_2022	COG0848	biopolymer transport protein
CH64_2023	COG0811	peptide transport
CH64_2024	COG0626	cystathionine gamma-synthase activity
CH64_2025	COG0586	Pfam SNARE associated Golgi protein
CH64_2026	COG2207	Transcriptional regulator
CH64_2027	COG1979	alcohol dehydrogenase
CH64_2028	COG0656	L-ascorbic acid biosynthetic process
CH64_203	COG2198	Histidine kinase
CH64_203	COG0643	Histidine kinase
CH64_2030	COG2132	Multicopper oxidase
CH64_2031	COG0204	Acyl-transferase
CH64_2032	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH64_2033	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH64_2034	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH64_2036	COG0187	DNA topoisomerase II activity
CH64_2037	COG3150	esterase
CH64_2038	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH64_2039	COG3151	Protein conserved in bacteria
CH64_204	COG0835	chemotaxis
CH64_2040	COG0494	nUDIX hydrolase
CH64_2042	COG1538	Outer membrane efflux protein
CH64_2044	COG0754	glutathionylspermidine amidase activity
CH64_2045	COG3384	dioxygenase
CH64_2048	COG0531	amino acid
CH64_2049	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CH64_2049	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH64_205	COG0840	transmembrane signaling receptor activity
CH64_2050	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CH64_2051	COG3025	triphosphatase activity
CH64_2052	COG4991	sh3 domain protein
CH64_2053	COG0617	tRNA 3'-terminal CCA addition
CH64_2054	COG1968	undecaprenyl-diphosphatase activity
CH64_2055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH64_2056	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CH64_2057	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CH64_2059	COG0358	DNA primase activity
CH64_206	COG0840	transmembrane signaling receptor activity
CH64_2060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH64_2065	COG2003	Belongs to the UPF0758 family
CH64_207	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH64_2070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH64_2077	COG2378	regulation of single-species biofilm formation
CH64_2079	COG3596	GTP binding
CH64_2087	COG1479	Protein of unknown function DUF262
CH64_209	COG0745	RESPONSE REGULATOR receiver
CH64_2091	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CH64_2094	COG4735	regulation of single-species biofilm formation
CH64_2097	COG4983	Phage plasmid primase, P4 family domain protein
CH64_21	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_210	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH64_2111	COG0297	glycogen (starch) synthase activity
CH64_2111	COG0438	transferase activity, transferring glycosyl groups
CH64_2112	COG0297	glycogen (starch) synthase activity
CH64_2119	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CH64_212	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH64_2121	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CH64_2122	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_2122	COG1263	PTS System
CH64_2124	COG0531	amino acid
CH64_2125	COG0076	glutamate decarboxylase activity
CH64_2126	COG3247	response to pH
CH64_2127	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH64_2127	COG1902	pentaerythritol trinitrate reductase activity
CH64_2128	COG2813	Specifically methylates the guanine in position
CH64_213	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH64_2130	COG1451	nucleotide metabolic process
CH64_2131	COG0673	inositol 2-dehydrogenase activity
CH64_2132	COG0861	Integral membrane protein TerC family
CH64_2133	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CH64_2135	COG2721	sulfolactate sulfo-lyase activity
CH64_2136	COG0246	Mannitol dehydrogenase
CH64_2137	COG1904	glucuronate isomerase
CH64_2138	COG2271	Major facilitator Superfamily
CH64_2141	COG0586	Pfam SNARE associated Golgi protein
CH64_2144	COG4575	ribosome binding
CH64_2145	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH64_2147	COG2259	Doxx family
CH64_2148	COG0435	Glutathione S-transferase
CH64_2149	COG0583	DNA-binding transcription factor activity
CH64_215	COG3418	PFAM FlgN family protein
CH64_2150	COG1741	Belongs to the pirin family
CH64_2151	COG1064	alcohol dehydrogenase
CH64_2152	COG1566	PFAM secretion protein HlyD family protein
CH64_2156	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH64_2158	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH64_2159	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH64_216	COG2747	anti-sigma28 factor FlgM
CH64_2161	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH64_2163	COG0792	nuclease activity
CH64_2164	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH64_2165	COG2823	Periplasmic or secreted lipoprotein
CH64_2166	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH64_2167	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH64_2168	COG5002	protein histidine kinase activity
CH64_2168	COG2198	Histidine kinase
CH64_2168	COG0784	Response regulator, receiver
CH64_2169	COG1242	4 iron, 4 sulfur cluster binding
CH64_2170	COG0069	glutamate synthase activity
CH64_2170	COG0070	glutamate synthase
CH64_2170	COG0067	glutamate synthase
CH64_2171	COG0493	'glutamate synthase
CH64_2173	COG2969	positive regulation of protein catabolic process
CH64_2174	COG0625	glutathione transferase activity
CH64_2175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CH64_2176	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CH64_2177	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH64_2178	COG3105	Protein conserved in bacteria
CH64_2179	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH64_218	COG1815	bacterial-type flagellum-dependent cell motility
CH64_2180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH64_2181	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CH64_2182	COG5007	Belongs to the BolA IbaG family
CH64_2183	COG3113	response to antibiotic
CH64_2184	COG2854	intermembrane phospholipid transfer
CH64_2185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH64_2186	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH64_2187	COG1127	ABC transporter
CH64_2188	COG0530	calcium, potassium:sodium antiporter activity
CH64_2189	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH64_2189	COG0517	IMP dehydrogenase activity
CH64_219	COG1558	bacterial-type flagellum-dependent cell motility
CH64_2190	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH64_2191	COG3117	lipopolysaccharide transmembrane transporter activity
CH64_2192	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH64_2193	COG1137	ATPase activity
CH64_2194	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH64_2196	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_2197	COG1660	Displays ATPase and GTPase activities
CH64_2198	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_22	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CH64_22	COG3261	NADH dehydrogenase
CH64_220	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH64_2200	COG0540	Belongs to the ATCase OTCase family
CH64_2201	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CH64_2203	COG0366	Alpha amylase catalytic
CH64_2204	COG1263	PTS System
CH64_2204	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_2207	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_2207	COG3711	transcriptional antiterminator
CH64_221	COG1749	Flagellar hook protein flgE
CH64_2210	COG3964	amidohydrolase
CH64_2216	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH64_2217	COG3783	Cytochrome b(562)
CH64_2218	COG0312	modulator of DNA gyrase
CH64_2220	COG2732	(Barnase) inhibitor
CH64_2223	COG1289	transmembrane transporter activity
CH64_2224	COG1566	PFAM secretion protein HlyD family protein
CH64_2226	COG0583	DNA-binding transcription factor activity
CH64_2227	COG0312	modulator of DNA gyrase
CH64_2228	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH64_2229	COG3164	Protein of unknown function
CH64_223	COG4786	Flagellar basal body rod
CH64_2230	COG1530	ribonuclease E activity
CH64_2232	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH64_2233	COG1792	Involved in formation and maintenance of cell shape
CH64_2234	COG1077	Cell shape determining protein MreB Mrl
CH64_2235	COG2200	EAL domain
CH64_2235	COG2199	diguanylate cyclase activity
CH64_2236	COG0604	alcohol dehydrogenase
CH64_2238	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CH64_2239	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CH64_2240	COG0511	ligase activity, forming carbon-carbon bonds
CH64_2241	COG0439	Biotin carboxylase
CH64_2242	COG3924	membrane
CH64_2243	COG4145	pantothenate transmembrane transporter activity
CH64_2244	COG2264	protein methyltransferase activity
CH64_2245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH64_2246	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH64_2247	COG0745	RESPONSE REGULATOR receiver
CH64_2247	COG3706	GGDEF domain
CH64_2248	COG3133	Outer membrane lipoprotein
CH64_2249	COG1278	Cold shock
CH64_2250	COG1278	Cold shock
CH64_2251	COG1278	Cold shock
CH64_2252	COG1560	Kdo2-lipid A biosynthetic process
CH64_2255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_2256	COG4597	amino acid ABC transporter
CH64_2257	COG0765	amino acid transport
CH64_2258	COG1126	abc transporter atp-binding protein
CH64_2260	COG0025	NhaP-type Na H and K H
CH64_2261	COG2252	PERMEase
CH64_2264	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH64_2265	COG2315	Protein conserved in bacteria
CH64_2266	COG1448	Aminotransferase
CH64_2267	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH64_2268	COG0305	Participates in initiation and elongation during chromosome replication
CH64_227	COG1256	bacterial-type flagellum assembly
CH64_2271	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH64_2273	COG0735	belongs to the Fur family
CH64_2274	COG3237	CsbD-like
CH64_2275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CH64_2276	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH64_2277	COG2937	Belongs to the GPAT DAPAT family
CH64_2279	COG3161	chorismate lyase activity
CH64_228	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH64_2282	COG4580	involved in the transport of maltose and maltodextrins
CH64_2285	COG2182	Extracellular solute-binding protein
CH64_2286	COG1175	transmembrane transport
CH64_2287	COG3833	ABC-type maltose transport systems, permease component
CH64_2288	COG3223	Belongs to the PsiE family
CH64_2290	COG0527	aspartate kinase activity
CH64_2293	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CH64_2295	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH64_2296	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CH64_23	COG0651	ATP synthesis coupled electron transport
CH64_2304	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH64_2305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH64_2306	COG0009	L-threonylcarbamoyladenylate synthase
CH64_2307	COG0551	DNA topoisomerase type I activity
CH64_2309	COG0758	DNA mediated transformation
CH64_2310	COG0242	peptide deformylase activity
CH64_2311	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH64_2312	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CH64_2312	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH64_2313	COG0569	domain protein
CH64_2314	COG1970	mechanosensitive ion channel activity
CH64_2315	COG3036	rescue of stalled ribosome
CH64_2316	COG0789	Transcriptional regulator
CH64_2318	COG0203	ribosomal protein L17
CH64_2319	COG0202	RNA polymerase activity
CH64_2320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH64_2322	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CH64_2323	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH64_2324	COG0201	protein transport
CH64_2325	COG0200	Binds to the 23S rRNA
CH64_2326	COG1841	ribosomal large subunit assembly
CH64_2327	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CH64_2331	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CH64_2334	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH64_2335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH64_2336	COG0255	Belongs to the universal ribosomal protein uL29 family
CH64_2337	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH64_2338	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CH64_2339	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CH64_2340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH64_2341	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CH64_2342	COG0089	rRNA binding
CH64_2344	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CH64_2345	COG0051	transcription antitermination factor activity, RNA binding
CH64_2350	COG0049	tRNA binding
CH64_2351	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH64_2352	COG2168	tRNA wobble position uridine thiolation
CH64_2353	COG2923	Belongs to the DsrF TusC family
CH64_2354	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH64_2355	COG2964	Protein conserved in bacteria
CH64_2356	COG0545	Peptidyl-prolyl cis-trans isomerase
CH64_2358	COG1047	Peptidyl-prolyl cis-trans
CH64_2359	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH64_2361	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH64_2362	COG0488	(ABC) transporter
CH64_2363	COG1216	Glycosyl transferase, family 2
CH64_2367	COG0429	hydrolase of the alpha beta-hydrolase fold
CH64_2368	COG3089	Belongs to the UPF0270 family
CH64_2369	COG3954	Phosphoribulokinase
CH64_237	COG2882	bacterial-type flagellum organization
CH64_2370	COG1765	OsmC-like protein
CH64_2372	COG1289	transmembrane transporter activity
CH64_2375	COG0433	COG0433 Predicted ATPase
CH64_2376	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH64_2377	COG1486	melibiose metabolic process
CH64_2378	COG1609	Transcriptional regulator
CH64_2379	COG0738	Major facilitator superfamily
CH64_2380	COG0402	S-adenosylhomocysteine deaminase activity
CH64_2381	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH64_2382	COG2146	nitrite reductase [NAD(P)H] activity
CH64_2384	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH64_2384	COG1648	precorrin-2 dehydrogenase activity
CH64_2385	COG0180	Tryptophanyl-tRNA synthetase
CH64_2386	COG0546	phosphoglycolate phosphatase activity
CH64_2387	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH64_239	COG1317	bacterial-type flagellum organization
CH64_2391	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH64_2392	COG4796	Type ii and iii secretion system protein
CH64_2398	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH64_2399	COG0494	nUDIX hydrolase
CH64_24	COG4237	Hydrogenase 4 membrane
CH64_240	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH64_2401	COG1011	Hydrolase
CH64_2402	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH64_2404	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CH64_2406	COG0745	RESPONSE REGULATOR receiver
CH64_2407	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH64_2408	COG2183	response to ionizing radiation
CH64_2409	COG1918	ferrous iron import across plasma membrane
CH64_2412	COG0596	Alpha beta hydrolase
CH64_2414	COG0316	Belongs to the HesB IscA family
CH64_2414	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CH64_2415	COG1640	4-alpha-glucanotransferase
CH64_2416	COG0058	SHG alpha-glucan phosphorylase activity
CH64_2417	COG2909	trisaccharide binding
CH64_242	COG1677	Flagellar hook-basal body complex protein FliE
CH64_2420	COG0705	Rhomboid family
CH64_2421	COG1349	DNA-binding transcription factor activity
CH64_2422	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH64_2423	COG0058	SHG alpha-glucan phosphorylase activity
CH64_2424	COG0297	glycogen (starch) synthase activity
CH64_2425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH64_2426	COG1523	belongs to the glycosyl hydrolase 13 family
CH64_2427	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CH64_2428	COG3275	phosphorelay sensor kinase activity
CH64_2431	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH64_2432	COG2095	MarC family integral membrane protein
CH64_2433	COG3265	gluconokinase activity
CH64_2434	COG2610	gluconate transmembrane transporter activity
CH64_2435	COG1609	Transcriptional regulator
CH64_2436	COG1741	Belongs to the pirin family
CH64_2437	COG1247	-acetyltransferase
CH64_2438	COG1082	Xylose isomerase domain protein TIM barrel
CH64_2439	COG0673	inositol 2-dehydrogenase activity
CH64_2443	COG3718	enzyme involved in inositol metabolism
CH64_2446	COG2814	Major facilitator Superfamily
CH64_2447	COG0583	DNA-binding transcription factor activity
CH64_245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH64_2451	COG2081	HI0933 family
CH64_2453	COG0306	phosphate transporter
CH64_2456	COG0589	response to stress
CH64_2459	COG0742	ribosomal rna small subunit methyltransferase
CH64_2462	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH64_2463	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH64_2464	COG1295	ribonuclease BN
CH64_2465	COG2134	cdp-diacylglycerol pyrophosphatase
CH64_2466	COG2982	Protein involved in outer membrane biogenesis
CH64_2467	COG2200	EAL domain
CH64_2468	COG1942	4-Oxalocrotonate Tautomerase
CH64_2469	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH64_2470	COG0612	Peptidase, M16
CH64_2471	COG1301	dicarboxylic acid transport
CH64_2473	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH64_2474	COG2199	diguanylate cyclase activity
CH64_2474	COG2200	EAL domain
CH64_2475	COG4608	Belongs to the ABC transporter superfamily
CH64_2476	COG0444	Belongs to the ABC transporter superfamily
CH64_2477	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH64_2478	COG0601	transmembrane transport
CH64_2479	COG0747	negative chemotaxis
CH64_2481	COG3210	domain, Protein
CH64_2482	COG2831	hemolysin activation secretion protein
CH64_2483	COG3210	domain, Protein
CH64_2485	COG2271	Major facilitator Superfamily
CH64_2486	COG3851	Histidine kinase
CH64_2487	COG2197	response regulator
CH64_2488	COG2194	sulfuric ester hydrolase activity
CH64_2489	COG1764	response to oxidative stress
CH64_2490	COG1846	Transcriptional regulator
CH64_2493	COG2986	histidine ammonia-lyase
CH64_2494	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CH64_2495	COG2979	Protein of unknown function (DUF533)
CH64_2497	COG2207	Transcriptional regulator
CH64_2497	COG1609	Transcriptional regulator
CH64_2498	COG4214	carbohydrate transport
CH64_25	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH64_2500	COG4213	ABC transporter substrate-binding protein
CH64_2501	COG2115	Belongs to the xylose isomerase family
CH64_2502	COG1070	Carbohydrate kinase
CH64_2503	COG1335	isochorismatase
CH64_2504	COG3274	enterobacterial common antigen metabolic process
CH64_2508	COG3276	selenocysteine insertion sequence binding
CH64_2509	COG1921	L-seryl-tRNASec selenium transferase activity
CH64_2511	COG3058	Necessary for formate dehydrogenase activity
CH64_2512	COG2864	formate dehydrogenase
CH64_2513	COG0437	4 iron, 4 sulfur cluster binding
CH64_2514	COG3383	formate dehydrogenase (NAD+) activity
CH64_2514	COG0243	molybdopterin cofactor binding
CH64_2515	COG0243	molybdopterin cofactor binding
CH64_2515	COG3383	formate dehydrogenase (NAD+) activity
CH64_2516	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CH64_2518	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH64_2519	COG0840	transmembrane signaling receptor activity
CH64_2520	COG2258	MOSC domain
CH64_2522	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH64_2524	COG3722	fumarate hydratase activity
CH64_2525	COG0246	Mannitol dehydrogenase
CH64_2526	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_2526	COG2213	PTS system mannitol-specific
CH64_2528	COG0751	glycine-tRNA ligase activity
CH64_2529	COG0752	glycyl-tRNA synthetase alpha subunit
CH64_2530	COG2818	Glycosylase
CH64_2535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH64_2536	COG0366	Alpha amylase catalytic
CH64_2537	COG3977	Valine--pyruvate aminotransferase
CH64_2538	COG0569	domain protein
CH64_2538	COG2985	domain, Protein
CH64_254	COG1191	sigma factor activity
CH64_2541	COG5645	(Lipo)protein
CH64_2542	COG0823	Involved in the tonB-independent uptake of proteins
CH64_2544	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH64_2545	COG2423	ornithine cyclodeaminase activity
CH64_2546	COG0561	phosphatase activity
CH64_2547	COG0187	DNA topoisomerase II activity
CH64_2548	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH64_2549	COG0592	DNA-directed DNA polymerase activity
CH64_2551	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH64_2552	COG0594	ribonuclease P activity
CH64_2554	COG0706	membrane insertase activity
CH64_2555	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CH64_2556	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CH64_2559	COG2011	ABC-type metal ion transport system permease component
CH64_256	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH64_2560	COG0840	transmembrane signaling receptor activity
CH64_2561	COG0431	NADPH-dependent FMN reductase
CH64_2565	COG2252	PERMEase
CH64_2566	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH64_2567	COG0765	amino acid transport
CH64_2568	COG0765	amino acid transport
CH64_2569	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_2571	COG3876	Protein conserved in bacteria
CH64_2573	COG1472	Belongs to the glycosyl hydrolase 3 family
CH64_2574	COG0704	Plays a role in the regulation of phosphate uptake
CH64_2576	COG0581	inorganic phosphate transmembrane transporter activity
CH64_2577	COG0573	inorganic phosphate transmembrane transporter activity
CH64_2578	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH64_2580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CH64_2581	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CH64_2582	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CH64_2583	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CH64_2585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CH64_2587	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CH64_2589	COG0356	it plays a direct role in the translocation of protons across the membrane
CH64_2590	COG3312	ion transport
CH64_2591	COG0357	Ribosomal RNA small subunit methyltransferase G
CH64_2592	COG0445	tRNA wobble uridine modification
CH64_2593	COG0716	FMN binding
CH64_2594	COG1522	sequence-specific DNA binding
CH64_2597	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CH64_2598	COG0714	Associated with various cellular activities
CH64_2599	COG3158	transport of potassium into the cell
CH64_26	COG0650	Formate hydrogenlyase subunit 4
CH64_2600	COG1869	D-ribose catabolic process
CH64_2602	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_2603	COG1879	ABC-type sugar transport system periplasmic component
CH64_2604	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH64_2605	COG0477	Major facilitator Superfamily
CH64_2606	COG1609	Transcriptional regulator
CH64_2607	COG2186	Transcriptional regulator
CH64_2612	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH64_2614	COG3084	Protein conserved in bacteria
CH64_2615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH64_2616	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH64_2617	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH64_2617	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH64_262	COG0506	proline dehydrogenase activity
CH64_262	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH64_262	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH64_2620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH64_2622	COG3852	Histidine kinase
CH64_2623	COG0174	glutamine synthetase
CH64_2625	COG1011	Hydrolase
CH64_2626	COG1295	ribonuclease BN
CH64_2627	COG1490	D-aminoacyl-tRNA deacylase activity
CH64_2628	COG0456	acetyltransferase
CH64_2629	COG3423	Transcriptional regulator
CH64_263	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH64_2630	COG2197	response regulator
CH64_2632	COG2982	Protein involved in outer membrane biogenesis
CH64_2633	COG2233	PERMEase
CH64_2634	COG0786	glutamate:sodium symporter activity
CH64_2635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH64_2636	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH64_2637	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH64_2638	COG1758	RNA polymerase activity
CH64_2640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH64_2641	COG2860	membrane
CH64_2642	COG1024	Enoyl-CoA hydratase
CH64_2643	COG5001	Diguanylate cyclase
CH64_2644	COG1561	YicC-like family, N-terminal region
CH64_2646	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CH64_2647	COG1309	transcriptional regulator
CH64_2648	COG0756	dUTP diphosphatase activity
CH64_2649	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH64_2650	COG2003	Belongs to the UPF0758 family
CH64_2651	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CH64_2652	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH64_2653	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CH64_2654	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CH64_2656	COG1519	Transferase
CH64_2657	COG0859	PFAM glycosyl transferase family 9
CH64_2658	COG0859	PFAM glycosyl transferase family 9
CH64_2659	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH64_2660	COG0156	8-amino-7-oxononanoate synthase activity
CH64_2662	COG2861	carbohydrate metabolic process
CH64_2663	COG4942	peptidase
CH64_2664	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CH64_2665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH64_2666	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH64_2667	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CH64_2668	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CH64_2669	COG1045	serine acetyltransferase
CH64_2670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH64_2671	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH64_2671	COG2169	Transcriptional regulator
CH64_2672	COG2205	protein histidine kinase activity
CH64_2673	COG0745	RESPONSE REGULATOR receiver
CH64_2674	COG3678	ATP-independent chaperone mediated protein folding
CH64_2675	COG4974	Belongs to the 'phage' integrase family
CH64_2677	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CH64_2679	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH64_268	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CH64_2683	COG3152	Membrane
CH64_2685	COG2814	Major facilitator Superfamily
CH64_2686	COG1494	fructose-1,6-bisphosphatase
CH64_2688	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH64_2689	COG3074	FtsZ-dependent cytokinesis
CH64_269	COG1113	amino acid transport
CH64_2690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CH64_2691	COG1575	Belongs to the MenA family. Type 1 subfamily
CH64_2692	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CH64_2693	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CH64_2694	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH64_2695	COG1609	Transcriptional regulator
CH64_2696	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH64_2697	COG0254	rRNA binding
CH64_2699	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CH64_27	COG0651	ATP synthesis coupled electron transport
CH64_2700	COG0626	cystathionine gamma-synthase activity
CH64_2701	COG0460	homoserine dehydrogenase
CH64_2701	COG0527	aspartate kinase activity
CH64_2703	COG0477	Major facilitator Superfamily
CH64_2704	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CH64_2707	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CH64_2709	COG0165	Argininosuccinate lyase
CH64_271	COG1187	pseudouridine synthase activity
CH64_2710	COG1629	transport
CH64_2716	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH64_2717	COG0678	peroxiredoxin activity
CH64_2717	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH64_2720	COG1309	transcriptional regulator
CH64_2722	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH64_2724	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CH64_2732	COG1879	ABC-type sugar transport system periplasmic component
CH64_2733	COG1129	ABC transporter
CH64_2734	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_2735	COG0583	DNA-binding transcription factor activity
CH64_2736	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_2737	COG3085	chromosome segregation
CH64_274	COG0366	Alpha amylase catalytic
CH64_2740	COG3978	acetolactate synthase activity
CH64_2741	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH64_2742	COG0129	dihydroxy-acid dehydratase activity
CH64_2743	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH64_2744	COG0583	DNA-binding transcription factor activity
CH64_2745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CH64_2746	COG3121	Chaperone
CH64_2749	COG3121	Chaperone
CH64_275	COG0840	transmembrane signaling receptor activity
CH64_2751	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH64_2754	COG0248	Ppx GppA phosphatase
CH64_2756	COG3118	belongs to the thioredoxin family
CH64_2757	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH64_2758	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH64_2759	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH64_2760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH64_2761	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH64_2762	COG1088	dTDP-glucose 4,6-dehydratase activity
CH64_2763	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH64_2764	COG0456	acetyltransferase
CH64_2765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH64_2766	COG2244	polysaccharide biosynthetic process
CH64_2767	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH64_277	COG3136	membrane protein required for alginate biosynthesis
CH64_2770	COG1113	amino acid transport
CH64_2775	COG3071	HemY protein
CH64_2776	COG2959	enzyme of heme biosynthesis
CH64_2777	COG1587	Uroporphyrinogen-III synthase
CH64_2778	COG0181	hydroxymethylbilane synthase activity
CH64_2779	COG3072	Adenylate cyclase
CH64_2782	COG5567	small periplasmic lipoprotein
CH64_2783	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CH64_2784	COG3159	Protein conserved in bacteria
CH64_2785	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH64_2786	COG1011	Hydrolase
CH64_2787	COG0210	DNA helicase
CH64_2789	COG5441	Belongs to the UPF0261 family
CH64_2790	COG5564	TIM-barrel signal transduction protein
CH64_2792	COG0598	Magnesium transport protein CorA
CH64_2794	COG2050	protein possibly involved in aromatic compounds catabolism
CH64_2796	COG0514	ATP-dependent DNA helicase (RecQ)
CH64_2797	COG1280	lysine exporter protein (LysE YggA)
CH64_2798	COG1280	lysine exporter protein (LysE YggA)
CH64_2799	COG2267	carboxylic ester hydrolase activity
CH64_28	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH64_280	COG2197	response regulator
CH64_2800	COG0561	phosphatase activity
CH64_2801	COG0584	glycerophosphoryl diester phosphodiesterase
CH64_2802	COG2271	Major facilitator Superfamily
CH64_2803	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH64_2804	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CH64_2805	COG0247	lactate metabolic process
CH64_2807	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH64_2808	COG0425	Belongs to the sulfur carrier protein TusA family
CH64_281	COG0322	excinuclease ABC activity
CH64_2810	COG3714	YhhN family
CH64_2813	COG3776	membrane
CH64_2814	COG0742	ribosomal rna small subunit methyltransferase
CH64_2815	COG0552	protein localization to endoplasmic reticulum
CH64_2815	COG0552	protein localization to endoplasmic reticulum
CH64_2816	COG2884	Cell division ATP-binding protein ftsE
CH64_2817	COG2177	Part of the ABC transporter FtsEX involved in
CH64_2819	COG0456	acetyltransferase
CH64_282	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH64_2821	COG0683	leucine binding
CH64_2822	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH64_2823	COG4177	L-phenylalanine transmembrane transporter activity
CH64_2824	COG0411	ABC transporter
CH64_2825	COG0410	ABC transporter
CH64_2832	COG1653	transport
CH64_2833	COG1175	transmembrane transport
CH64_2834	COG0395	ABC-type sugar transport system, permease component
CH64_2835	COG3842	ATPase activity
CH64_2836	COG0584	glycerophosphoryl diester phosphodiesterase
CH64_2837	COG0679	Auxin Efflux Carrier
CH64_2838	COG0583	DNA-binding transcription factor activity
CH64_2840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CH64_2841	COG0412	Dienelactone hydrolase
CH64_2842	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CH64_2844	COG1966	Carbon starvation protein
CH64_2845	COG0586	Pfam SNARE associated Golgi protein
CH64_2846	COG1322	Protein conserved in bacteria
CH64_2847	COG2226	methyltransferase
CH64_2849	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CH64_2850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH64_2851	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH64_2852	COG0805	protein transport
CH64_2856	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CH64_2858	COG0183	Belongs to the thiolase family
CH64_2859	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH64_2859	COG1024	Enoyl-CoA hydratase
CH64_2861	COG1739	Uncharacterized protein family UPF0029
CH64_2862	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH64_2870	COG1072	(Pantothenic acid kinase))
CH64_2878	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH64_2879	COG0250	Participates in transcription elongation, termination and antitermination
CH64_2880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CH64_2882	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CH64_2883	COG0222	ribosome binding
CH64_2884	COG0085	RNA polymerase activity
CH64_2885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CH64_2887	COG2022	thiamine diphosphate biosynthetic process
CH64_2888	COG2104	thiamine diphosphate biosynthetic process
CH64_2889	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH64_2891	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CH64_2893	COG2816	NAD+ diphosphatase activity
CH64_2894	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CH64_2895	COG1515	deoxyribonuclease V activity
CH64_2896	COG3068	Protein conserved in bacteria
CH64_2899	COG0151	Belongs to the GarS family
CH64_29	COG0375	protein maturation
CH64_2900	COG0138	bifunctional purine biosynthesis protein purh
CH64_2906	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH64_2907	COG3162	membrane
CH64_2908	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CH64_2909	COG1301	dicarboxylic acid transport
CH64_2910	COG2197	response regulator
CH64_2911	COG0784	Response regulator, receiver
CH64_2911	COG2205	protein histidine kinase activity
CH64_2911	COG5002	protein histidine kinase activity
CH64_294	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_2942	COG2391	methyltransferase activity
CH64_2943	COG0425	Belongs to the sulfur carrier protein TusA family
CH64_2944	COG3264	Mechanosensitive ion channel
CH64_2944	COG1196	nuclear chromosome segregation
CH64_2946	COG4774	siderophore transport
CH64_2948	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH64_2949	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH64_2950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH64_2951	COG4558	Periplasmic binding protein
CH64_2952	COG3720	iron ion transport
CH64_2956	COG3721	Heme iron utilization protein
CH64_2958	COG0114	fumarate hydratase activity
CH64_2959	COG0281	malic enzyme
CH64_2964	COG0463	Glycosyl transferase, family 2
CH64_2965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CH64_2967	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CH64_2969	COG3316	Transposase and inactivated derivatives
CH64_2973	COG1309	transcriptional regulator
CH64_2974	COG1929	Belongs to the glycerate kinase type-1 family
CH64_2975	COG4232	protein-disulfide reductase activity
CH64_2977	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH64_298	COG0561	phosphatase activity
CH64_2980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CH64_2981	COG0459	protein refolding
CH64_2983	COG1509	lysine 2,3-aminomutase activity
CH64_2984	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH64_2986	COG2076	Multidrug Resistance protein
CH64_2988	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH64_2989	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH64_299	COG2197	response regulator
CH64_2990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH64_2991	COG1053	succinate dehydrogenase
CH64_2993	COG1511	domain protein
CH64_2993	COG3264	Mechanosensitive ion channel
CH64_2994	COG0688	phosphatidylethanolamine metabolic process
CH64_2995	COG1162	GTPase activity
CH64_2996	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH64_30	COG0298	carbon dioxide binding
CH64_300	COG2223	nitrite transmembrane transporter activity
CH64_3000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH64_3001	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH64_3001	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH64_3002	COG0802	atpase or kinase
CH64_3003	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH64_3004	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CH64_3005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CH64_3006	COG1923	regulation of RNA biosynthetic process
CH64_3007	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH64_3008	COG0330	HflC and HflK could
CH64_3009	COG0330	HflC and HflK could
CH64_301	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CH64_3010	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH64_3011	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CH64_3012	COG1959	2 iron, 2 sulfur cluster binding
CH64_3013	COG0557	exoribonuclease II activity
CH64_3014	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH64_3015	COG1960	acyl-CoA dehydrogenase activity
CH64_3016	COG3650	response to hydrogen peroxide
CH64_3017	COG1073	alpha beta
CH64_3019	COG0360	Binds together with S18 to 16S ribosomal RNA
CH64_302	COG1140	nitrate reductase beta subunit
CH64_3020	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH64_3021	COG0359	binds to the 23S rRNA
CH64_3023	COG3061	Opacity-associated protein A
CH64_3024	COG0545	Peptidyl-prolyl cis-trans isomerase
CH64_3026	COG0737	Belongs to the 5'-nucleotidase family
CH64_3027	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH64_3028	COG1218	3'(2'),5'-bisphosphate nucleotidase
CH64_303	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CH64_3030	COG1253	flavin adenine dinucleotide binding
CH64_3031	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH64_3032	COG0729	surface antigen
CH64_3034	COG2105	PFAM AIG2 family protein
CH64_3035	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH64_3036	COG0840	transmembrane signaling receptor activity
CH64_3038	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH64_304	COG2181	nitrate reductase activity
CH64_3042	COG0039	L-malate dehydrogenase activity
CH64_3043	COG3423	Transcriptional regulator
CH64_3045	COG0142	geranyltranstransferase activity
CH64_3048	COG0697	spore germination
CH64_3049	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CH64_3050	COG0642	Histidine kinase
CH64_3051	COG0745	RESPONSE REGULATOR receiver
CH64_3052	COG2027	D-alanyl-D-alanine carboxypeptidase
CH64_3053	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH64_3054	COG1534	Rna-binding protein
CH64_3055	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CH64_3056	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CH64_3057	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH64_3059	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH64_306	COG3493	citrate carrier protein
CH64_3062	COG0779	Required for maturation of 30S ribosomal subunits
CH64_3063	COG0195	Participates in both transcription termination and antitermination
CH64_3064	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CH64_3065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CH64_3066	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CH64_3068	COG1185	polyribonucleotide nucleotidyltransferase activity
CH64_307	COG4565	transcriptional regulatory protein
CH64_3070	COG0513	Belongs to the DEAD box helicase family
CH64_3072	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH64_3076	COG3153	acetyltransferase
CH64_3077	COG2827	Endonuclease containing a URI domain
CH64_3078	COG0531	amino acid
CH64_3079	COG1982	Orn Lys Arg decarboxylase major
CH64_308	COG3290	protein histidine kinase activity
CH64_3082	COG1653	transport
CH64_3084	COG0395	ABC-type sugar transport system, permease component
CH64_3085	COG3842	ATPase activity
CH64_3087	COG3787	Belongs to the UPF0306 family
CH64_3088	COG0702	epimerase
CH64_3089	COG0602	queuosine metabolic process
CH64_309	COG2066	Belongs to the glutaminase family
CH64_3091	COG4608	Belongs to the ABC transporter superfamily
CH64_3092	COG0444	Belongs to the ABC transporter superfamily
CH64_3094	COG0601	transmembrane transport
CH64_3096	COG2731	YhcH YjgK YiaL family protein
CH64_3098	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH64_31	COG2949	membrane
CH64_3102	COG2927	DNA polymerase III (CHI subunit)
CH64_3103	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CH64_3104	COG0795	lipopolysaccharide-transporting ATPase activity
CH64_3105	COG0795	lipopolysaccharide-transporting ATPase activity
CH64_3107	COG0582	viral genome integration into host DNA
CH64_3108	COG0582	viral genome integration into host DNA
CH64_3109	COG1518	maintenance of DNA repeat elements
CH64_3110	COG1203	CRISPR-associated helicase, Cas3
CH64_312	COG0672	)-iron permease
CH64_3129	COG3121	Chaperone
CH64_3130	COG3188	usher protein
CH64_3139	COG3501	Rhs element vgr protein
CH64_3147	COG2197	response regulator
CH64_3148	COG0784	Response regulator, receiver
CH64_3148	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_3148	COG2198	Histidine kinase
CH64_3148	COG2205	protein histidine kinase activity
CH64_3149	COG1388	LysM domain
CH64_3149	COG2373	Large extracellular alpha-helical protein
CH64_3149	COG4932	domain protein
CH64_315	COG1136	(ABC) transporter
CH64_315	COG0577	efflux transmembrane transporter activity
CH64_3150	COG2850	peptidyl-arginine hydroxylation
CH64_3156	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH64_3157	COG1830	Aldolase
CH64_3158	COG1879	ABC-type sugar transport system periplasmic component
CH64_3159	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_3160	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_3161	COG1129	ABC transporter
CH64_3162	COG2390	Transcriptional regulator
CH64_3163	COG1070	Carbohydrate kinase
CH64_3164	COG0859	PFAM glycosyl transferase family 9
CH64_3167	COG2235	arginine
CH64_3168	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_3169	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH64_317	COG1136	(ABC) transporter
CH64_317	COG0577	efflux transmembrane transporter activity
CH64_3171	COG2376	Dihydroxyacetone kinase
CH64_3172	COG1461	Dihydroxyacetone kinase
CH64_3173	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH64_3173	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_3173	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CH64_3174	COG3284	Transcriptional regulator
CH64_3180	COG3706	GGDEF domain
CH64_3185	COG0583	DNA-binding transcription factor activity
CH64_3186	COG0667	Aldo Keto reductase
CH64_3187	COG2813	Specifically methylates the guanine in position
CH64_3188	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH64_3190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CH64_3192	COG2823	Periplasmic or secreted lipoprotein
CH64_3194	COG4667	esterase of the alpha-beta hydrolase superfamily
CH64_3196	COG0084	hydrolase, TatD family'
CH64_3197	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH64_3198	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH64_3199	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CH64_32	COG0281	malic enzyme
CH64_3200	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH64_3202	COG3726	membrane protein affecting hemolysin expression
CH64_3203	COG0560	Phosphoserine phosphatase
CH64_3206	COG0604	alcohol dehydrogenase
CH64_3208	COG0488	(ABC) transporter
CH64_3209	COG0582	viral genome integration into host DNA
CH64_321	COG4114	ferric iron reductase
CH64_3211	COG2885	chlorophyll binding
CH64_3212	COG2199	diguanylate cyclase activity
CH64_3214	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH64_3215	COG0741	lytic transglycosylase activity
CH64_3216	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH64_3217	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CH64_3218	COG3708	Transcriptional regulator
CH64_3218	COG2207	Transcriptional regulator
CH64_3219	COG0406	alpha-ribazole phosphatase activity
CH64_322	COG0006	proline dipeptidase activity
CH64_3220	COG3045	CreA protein
CH64_3221	COG0745	RESPONSE REGULATOR receiver
CH64_3225	COG3022	response to hydroperoxide
CH64_3226	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH64_3227	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH64_323	COG0457	Tetratricopeptide repeat
CH64_3230	COG1584	GPR1 FUN34 yaaH family protein
CH64_3232	COG0484	heat shock protein binding
CH64_3233	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH64_3234	COG0583	DNA-binding transcription factor activity
CH64_3236	COG0196	riboflavin kinase activity
CH64_3237	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CH64_3238	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CH64_3239	COG1047	Peptidyl-prolyl cis-trans
CH64_324	COG1649	PFAM Uncharacterised BCR, COG1649
CH64_324	COG0726	polysaccharide deacetylase
CH64_3240	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CH64_3241	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CH64_3242	COG0505	Belongs to the CarA family
CH64_3243	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH64_3244	COG1280	lysine exporter protein (LysE YggA)
CH64_3245	COG2966	Psort location CytoplasmicMembrane, score
CH64_3247	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH64_3248	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH64_3249	COG2967	ApaG domain
CH64_325	COG1215	transferase activity, transferring glycosyl groups
CH64_3252	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH64_3253	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH64_3256	COG0564	pseudouridine synthase activity
CH64_3258	COG0417	DNA replication proofreading
CH64_3259	COG0586	Pfam SNARE associated Golgi protein
CH64_3261	COG1178	ABC-type Fe3 transport system permease component
CH64_3262	COG4143	(ABC) transporter
CH64_3263	COG4533	DNA binding
CH64_3264	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH64_3266	COG2814	Major facilitator Superfamily
CH64_3271	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CH64_3272	COG0473	3-isopropylmalate dehydrogenase activity
CH64_3273	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CH64_3275	COG1022	Amp-dependent synthetase and ligase
CH64_3276	COG0028	Belongs to the TPP enzyme family
CH64_3278	COG1609	Transcriptional regulator
CH64_3281	COG0275	rRNA processing
CH64_3282	COG3116	cell division
CH64_3283	COG0768	penicillin binding
CH64_3284	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH64_3285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH64_3286	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH64_3288	COG0772	Belongs to the SEDS family
CH64_3289	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CH64_329	COG1702	phosphate starvation-inducible protein PhoH
CH64_3290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH64_3292	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH64_3293	COG0849	cell division
CH64_3294	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH64_3298	COG0653	protein targeting
CH64_3299	COG0494	nUDIX hydrolase
CH64_330	COG0387	Pfam Sodium calcium exchanger
CH64_3300	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CH64_3302	COG0237	dephospho-CoA kinase activity
CH64_3303	COG0516	GMP reductase activity
CH64_3306	COG1459	type II secretion system
CH64_3307	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH64_3308	COG4969	Belongs to the N-Me-Phe pilin family
CH64_3310	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH64_3311	COG3725	Membrane protein required for beta-lactamase induction
CH64_3312	COG1113	amino acid transport
CH64_3313	COG2186	Transcriptional regulator
CH64_3314	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH64_3315	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH64_3316	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH64_3318	COG2207	Transcriptional regulator
CH64_332	COG0583	DNA-binding transcription factor activity
CH64_3321	COG3112	Uncharacterised protein family (UPF0231)
CH64_3322	COG0697	spore germination
CH64_333	COG3850	Histidine kinase
CH64_3331	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CH64_3333	COG2132	Multicopper oxidase
CH64_3334	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH64_3335	COG0288	reversible hydration of carbon dioxide
CH64_3336	COG1131	(ABC) transporter
CH64_3337	COG0842	Transport permease protein
CH64_3338	COG0726	polysaccharide deacetylase
CH64_3339	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CH64_3341	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CH64_3342	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CH64_3343	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH64_3344	COG0617	tRNA 3'-terminal CCA addition
CH64_3345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH64_3346	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH64_3347	COG1120	ATPase activity
CH64_3348	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH64_3349	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH64_335	COG1294	oxidase, subunit
CH64_3351	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CH64_3353	COG0316	Belongs to the HesB IscA family
CH64_3354	COG2860	membrane
CH64_3356	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH64_3357	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CH64_3358	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH64_3359	COG4999	Histidine kinase
CH64_3359	COG3850	Histidine kinase
CH64_3359	COG3437	response regulator, receiver
CH64_3359	COG2205	protein histidine kinase activity
CH64_336	COG1271	oxidase subunit
CH64_3360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH64_3361	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH64_3362	COG3956	TIGRFAM MazG family protein
CH64_3363	COG0504	CTP synthase activity
CH64_3368	COG0602	queuosine metabolic process
CH64_3369	COG0720	synthase
CH64_337	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH64_3370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CH64_3371	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH64_3372	COG0175	sulfate reduction
CH64_3373	COG2234	aminopeptidase activity
CH64_3374	COG1648	precorrin-2 dehydrogenase activity
CH64_3374	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH64_3375	COG0175	sulfate reduction
CH64_3376	COG2895	sulfate adenylyltransferase (ATP) activity
CH64_3377	COG0529	Catalyzes the synthesis of activated sulfate
CH64_338	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CH64_3380	COG0765	amino acid transport
CH64_3381	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_3382	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CH64_3385	COG0585	pseudouridine synthase activity
CH64_3386	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CH64_3387	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CH64_3388	COG4942	peptidase
CH64_3388	COG1388	LysM domain
CH64_3389	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH64_339	COG3138	arginine N-succinyltransferase
CH64_3390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH64_3393	COG3539	Fimbrial protein
CH64_3394	COG3188	usher protein
CH64_3395	COG3121	Chaperone
CH64_3397	COG3539	Fimbrial protein
CH64_34	COG1346	cytolysis
CH64_3404	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_3405	COG0577	efflux transmembrane transporter activity
CH64_3405	COG1136	(ABC) transporter
CH64_3406	COG1538	Outer membrane efflux protein
CH64_341	COG3724	N-succinylarginine dihydrolase activity
CH64_3410	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_3411	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_3413	COG0583	DNA-binding transcription factor activity
CH64_3414	COG2610	gluconate transmembrane transporter activity
CH64_3415	COG3048	D-serine ammonia-lyase activity
CH64_3418	COG0765	amino acid transport
CH64_3419	COG1126	abc transporter atp-binding protein
CH64_342	COG2988	succinylglutamate desuccinylase activity
CH64_3420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH64_3421	COG3665	Urea carboxylase-associated protein
CH64_3424	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CH64_3425	COG0640	Transcriptional regulator
CH64_3426	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH64_3426	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH64_3428	COG0243	molybdopterin cofactor binding
CH64_3429	COG0437	4 iron, 4 sulfur cluster binding
CH64_3430	COG3302	dmso reductase anchor subunit
CH64_3431	COG3381	protein complex oligomerization
CH64_3434	COG1129	ABC transporter
CH64_3435	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_3436	COG3959	Transketolase, thiamine diphosphate binding domain
CH64_3437	COG3958	Transketolase
CH64_3438	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH64_3443	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH64_3444	COG2137	regulation of response to DNA damage stimulus
CH64_3445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH64_3446	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH64_345	COG1228	amidohydrolase
CH64_3451	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH64_3452	COG1238	metal cluster binding
CH64_3453	COG2918	glutathione biosynthetic process
CH64_3454	COG1854	S-ribosylhomocysteine lyase activity
CH64_3455	COG4536	flavin adenine dinucleotide binding
CH64_3456	COG4137	Cytochrome C assembly protein
CH64_3457	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH64_3458	COG0228	four-way junction DNA binding
CH64_3459	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CH64_3460	COG0336	Belongs to the RNA methyltransferase TrmD family
CH64_3461	COG0335	large ribosomal subunit rRNA binding
CH64_3462	COG3137	Salt-induced outer membrane protein
CH64_3463	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH64_3464	COG3279	Response regulator of the LytR AlgR family
CH64_3465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH64_3466	COG1605	Chorismate mutase
CH64_3466	COG0287	Prephenate dehydrogenase
CH64_3467	COG0077	Prephenate dehydratase
CH64_3467	COG1605	Chorismate mutase
CH64_3468	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH64_3469	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH64_347	COG0402	S-adenosylhomocysteine deaminase activity
CH64_3470	COG0564	pseudouridine synthase activity
CH64_3472	COG0542	response to heat
CH64_3478	COG5544	Lipoprotein
CH64_3479	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH64_3480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH64_3480	COG0045	succinate-CoA ligase (ADP-forming) activity
CH64_3480	COG1042	CoA-binding domain protein
CH64_3482	COG3118	belongs to the thioredoxin family
CH64_3483	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH64_3484	COG2814	Major facilitator Superfamily
CH64_3485	COG1566	PFAM secretion protein HlyD family protein
CH64_3486	COG1846	Transcriptional regulator
CH64_3488	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH64_3489	COG2814	Major facilitator Superfamily
CH64_3492	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH64_3494	COG0436	Aminotransferase
CH64_3495	COG0235	Class ii aldolase
CH64_3496	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CH64_3497	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CH64_3499	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CH64_35	COG1380	Effector of murein hydrolase LrgA
CH64_3502	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH64_3503	COG1960	acyl-CoA dehydrogenase activity
CH64_3505	COG3034	peptidoglycan biosynthetic process
CH64_3506	COG0121	glutamine amidotransferase
CH64_3507	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH64_3508	COG1805	sodium ion transport
CH64_3509	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH64_351	COG1129	ABC transporter
CH64_3510	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH64_3511	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH64_3512	COG2871	sodium ion transport
CH64_3513	COG1477	protein flavinylation
CH64_3514	COG2991	Protein conserved in bacteria
CH64_3515	COG0584	glycerophosphoryl diester phosphodiesterase
CH64_3516	COG1181	Belongs to the D-alanine--D-alanine ligase family
CH64_3517	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CH64_3518	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH64_352	COG4211	Belongs to the binding-protein-dependent transport system permease family
CH64_3522	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CH64_3523	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CH64_3527	COG2226	methyltransferase
CH64_353	COG3443	Belongs to the bacterial solute-binding protein 9 family
CH64_3530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH64_3532	COG2974	May be involved in recombination
CH64_3533	COG1940	carbohydrate kinase activity
CH64_3534	COG0419	ATPase involved in DNA repair
CH64_3535	COG0420	3'-5' exonuclease activity
CH64_3536	COG0745	RESPONSE REGULATOR receiver
CH64_3537	COG5002	protein histidine kinase activity
CH64_3539	COG1114	Component of the transport system for branched-chain amino acids
CH64_3541	COG0366	Alpha amylase catalytic
CH64_3545	COG0450	alkyl hydroperoxide reductase
CH64_3546	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH64_3547	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CH64_3548	COG0343	queuine tRNA-ribosyltransferase activity
CH64_3549	COG1862	Preprotein translocase
CH64_355	COG4942	peptidase
CH64_3550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH64_3551	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH64_3553	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CH64_3554	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH64_3554	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH64_3556	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH64_3557	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH64_3558	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH64_3559	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CH64_356	COG0346	lactoylglutathione lyase activity
CH64_3560	COG0142	geranyltranstransferase activity
CH64_3561	COG1722	exodeoxyribonuclease VII activity
CH64_3562	COG0301	tRNA thio-modification
CH64_3562	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH64_3563	COG0693	protein deglycase activity
CH64_3564	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH64_3565	COG1666	GTP binding
CH64_3566	COG2814	Major facilitator Superfamily
CH64_3567	COG0109	protoheme IX farnesyltransferase activity
CH64_3568	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH64_3569	COG1845	cytochrome c oxidase, subunit III
CH64_357	COG0561	phosphatase activity
CH64_3570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH64_3571	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH64_3573	COG2223	nitrite transmembrane transporter activity
CH64_3574	COG3056	Lipoprotein
CH64_3575	COG0271	Belongs to the BolA IbaG family
CH64_3576	COG0544	peptidyl-prolyl cis-trans isomerase activity
CH64_3579	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH64_358	COG1349	DNA-binding transcription factor activity
CH64_3580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH64_3581	COG0776	regulation of translation
CH64_3582	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH64_3583	COG1555	photosystem II stabilization
CH64_3584	COG0824	Thioesterase
CH64_3585	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CH64_3586	COG4533	DNA binding
CH64_3587	COG0561	phosphatase activity
CH64_3589	COG1522	sequence-specific DNA binding
CH64_3590	COG1132	(ABC) transporter
CH64_3591	COG1132	(ABC) transporter
CH64_3592	COG0347	Belongs to the P(II) protein family
CH64_3593	COG0004	ammonium transporteR
CH64_3594	COG1946	Acyl-CoA thioesterase
CH64_3595	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH64_3596	COG3695	enzyme binding
CH64_36	COG2814	Major facilitator Superfamily
CH64_360	COG2197	response regulator
CH64_3600	COG1121	(ABC) transporter
CH64_3601	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH64_3602	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH64_3603	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH64_3604	COG0254	rRNA binding
CH64_3605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH64_3606	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_3607	COG1309	transcriptional regulator
CH64_3608	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH64_3609	COG3264	Mechanosensitive ion channel
CH64_3609	COG1196	nuclear chromosome segregation
CH64_361	COG0076	glutamate decarboxylase activity
CH64_3612	COG2832	Protein of unknown function (DUF454)
CH64_3613	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH64_3616	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CH64_3617	COG0326	Molecular chaperone. Has ATPase activity
CH64_3618	COG0563	adenylate kinase activity
CH64_3619	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CH64_362	COG0531	amino acid
CH64_3620	COG2244	polysaccharide biosynthetic process
CH64_3621	COG1215	transferase activity, transferring glycosyl groups
CH64_3622	COG0438	transferase activity, transferring glycosyl groups
CH64_3624	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH64_3628	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH64_3629	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH64_3629	COG4651	solute:proton antiporter activity
CH64_363	COG0012	GTP binding
CH64_3630	COG2223	nitrite transmembrane transporter activity
CH64_3631	COG0737	Belongs to the 5'-nucleotidase family
CH64_3632	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH64_3633	COG3735	TraB family
CH64_3634	COG2217	Heavy metal translocating P-type atpase
CH64_3635	COG0789	Transcriptional regulator
CH64_3636	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH64_3637	COG0330	HflC and HflK could
CH64_3638	COG3118	belongs to the thioredoxin family
CH64_3639	COG0300	oxidoreductase activity
CH64_3640	COG2755	lipolytic protein G-D-S-L family
CH64_3641	COG4181	ATPase activity
CH64_3642	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH64_3643	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH64_3644	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH64_3645	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH64_3646	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH64_3647	COG0215	cysteine-tRNA ligase activity
CH64_3648	COG2501	S4 domain
CH64_3649	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CH64_365	COG0193	aminoacyl-tRNA hydrolase activity
CH64_3651	COG0582	viral genome integration into host DNA
CH64_3652	COG0582	viral genome integration into host DNA
CH64_3663	COG3596	GTP binding
CH64_3671	COG0582	viral genome integration into host DNA
CH64_3672	COG1598	PFAM Uncharacterised protein family UPF0150
CH64_3675	COG3772	lysozyme
CH64_368	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH64_3684	COG0582	viral genome integration into host DNA
CH64_3695	COG3210	domain, Protein
CH64_3696	COG2831	hemolysin activation secretion protein
CH64_3699	COG5265	(ABC) transporter
CH64_370	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CH64_3703	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH64_3705	COG2197	response regulator
CH64_3706	COG1278	Cold shock
CH64_3707	COG1278	Cold shock
CH64_3708	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH64_3709	COG3706	GGDEF domain
CH64_371	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CH64_3711	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CH64_3712	COG0321	lipoyl(octanoyl) transferase activity
CH64_3713	COG2921	Belongs to the UPF0250 family
CH64_3714	COG1686	Belongs to the peptidase S11 family
CH64_3715	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH64_3716	COG0772	Belongs to the SEDS family
CH64_3717	COG0768	penicillin binding
CH64_3719	COG0799	negative regulation of ribosome biogenesis
CH64_3720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CH64_3721	COG1466	dna polymerase III delta subunit
CH64_3722	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CH64_3723	COG0495	leucyl-tRNA aminoacylation
CH64_3724	COG2888	peptidyl-tyrosine sulfation
CH64_3725	COG1126	abc transporter atp-binding protein
CH64_3726	COG0765	amino acid transport
CH64_3727	COG0765	amino acid transport
CH64_373	COG2890	protein-(glutamine-N5) methyltransferase activity
CH64_3730	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH64_3731	COG4535	Mg2 and Co2 transporter CorC
CH64_3732	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CH64_3733	COG1702	phosphate starvation-inducible protein PhoH
CH64_3734	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CH64_3735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH64_374	COG3094	Invasion gene expression up-regulator, SirB
CH64_3743	COG0367	asparagine synthase
CH64_3744	COG0647	UMP catabolic process
CH64_3745	COG1940	carbohydrate kinase activity
CH64_3745	COG1846	Transcriptional regulator
CH64_3746	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH64_3748	COG2190	(PTS) system
CH64_3748	COG1263	PTS System
CH64_3748	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_3749	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH64_375	COG2912	Transglutaminase-like superfamily
CH64_3753	COG0735	belongs to the Fur family
CH64_3756	COG0840	transmembrane signaling receptor activity
CH64_3758	COG0596	Alpha beta hydrolase
CH64_3759	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH64_3760	COG0033	Phosphoglucomutase
CH64_3764	COG0745	RESPONSE REGULATOR receiver
CH64_3766	COG2205	protein histidine kinase activity
CH64_3767	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CH64_3768	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CH64_377	COG0659	secondary active sulfate transmembrane transporter activity
CH64_3771	COG3272	Protein of unknown function (DUF1722)
CH64_3773	COG5212	phosphodiesterase
CH64_3774	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH64_3775	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH64_3776	COG1984	allophanate hydrolase subunit 2
CH64_3777	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CH64_378	COG3706	GGDEF domain
CH64_3781	COG0372	Belongs to the citrate synthase family
CH64_3782	COG2009	succinate dehydrogenase
CH64_3783	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH64_3784	COG1053	succinate dehydrogenase
CH64_3786	COG0567	Dehydrogenase, E1 component
CH64_3787	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH64_3789	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH64_3790	COG0737	Belongs to the 5'-nucleotidase family
CH64_3791	COG1271	oxidase subunit
CH64_3792	COG1294	oxidase, subunit
CH64_3793	COG4890	Cyd operon protein YbgT
CH64_3794	COG3790	cyd operon protein YbgE
CH64_3795	COG0824	Thioesterase
CH64_3796	COG0811	peptide transport
CH64_3797	COG0848	biopolymer transport protein
CH64_3798	COG3064	Membrane
CH64_3798	COG3064	Membrane
CH64_3799	COG0823	Involved in the tonB-independent uptake of proteins
CH64_3800	COG2885	chlorophyll binding
CH64_3801	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH64_3808	COG1230	cation diffusion facilitator family transporter
CH64_3809	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH64_3810	COG0588	phosphoglycerate mutase activity
CH64_3812	COG2017	converts alpha-aldose to the beta-anomer
CH64_3813	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CH64_3814	COG1085	galactose-1-phosphate uridylyltransferase
CH64_3815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH64_3817	COG1119	ATPase activity
CH64_3818	COG2005	Transcriptional regulator
CH64_3818	COG3585	molybdate ion transport
CH64_382	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH64_3820	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH64_3821	COG4149	molybdate abc transporter
CH64_3823	COG0561	phosphatase activity
CH64_3824	COG2706	6-phosphogluconolactonase activity
CH64_3826	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CH64_3827	COG0156	8-amino-7-oxononanoate synthase activity
CH64_3828	COG2226	methyltransferase
CH64_3829	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH64_3831	COG0556	nucleotide-excision repair
CH64_3832	COG4628	conserved protein (DUF2132)
CH64_3833	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH64_3834	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH64_3835	COG0315	cyclic pyranopterin monophosphate synthase activity
CH64_3836	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH64_3837	COG0314	molybdopterin synthase activity
CH64_3838	COG0670	Belongs to the BI1 family
CH64_3839	COG0842	Transport permease protein
CH64_384	COG3381	protein complex oligomerization
CH64_3840	COG0842	Transport permease protein
CH64_3841	COG1131	(ABC) transporter
CH64_3842	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_3843	COG1309	transcriptional regulator
CH64_3844	COG0513	Belongs to the DEAD box helicase family
CH64_3845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH64_3846	COG2239	Acts as a magnesium transporter
CH64_3848	COG1686	Belongs to the peptidase S11 family
CH64_3849	COG0277	FAD linked oxidase domain protein
CH64_3851	COG1403	HNH endonuclease
CH64_3853	COG2261	transglycosylase associated protein
CH64_3854	COG4807	Protein conserved in bacteria
CH64_3858	COG0411	ABC transporter
CH64_3859	COG0410	ABC transporter
CH64_386	COG0477	Major facilitator Superfamily
CH64_3860	COG2897	thiosulfate sulfurtransferase activity
CH64_3863	COG1732	Glycine betaine
CH64_3864	COG1174	glycine betaine transport
CH64_3865	COG1125	glycine betaine transport
CH64_3866	COG1174	glycine betaine transport
CH64_3868	COG0697	spore germination
CH64_387	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH64_3870	COG1199	ATP-dependent helicase activity
CH64_3871	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH64_3872	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH64_3876	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CH64_3878	COG1126	abc transporter atp-binding protein
CH64_3879	COG0765	amino acid transport
CH64_3880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_3881	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH64_3882	COG0783	Belongs to the Dps family
CH64_3883	COG4106	trans-aconitate 2-methyltransferase activity
CH64_3886	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH64_389	COG0673	inositol 2-dehydrogenase activity
CH64_3890	COG0488	(ABC) transporter
CH64_3891	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH64_3895	COG1136	(ABC) transporter
CH64_390	COG0728	peptidoglycan biosynthetic process
CH64_391	COG0018	arginyl-trna synthetase
CH64_392	COG3102	Protein conserved in bacteria
CH64_393	COG3142	Participates in the control of copper homeostasis
CH64_396	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH64_397	COG1801	Protein of unknown function DUF72
CH64_398	COG1335	isochorismatase
CH64_399	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CH64_40	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH64_40	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH64_400	COG0494	nUDIX hydrolase
CH64_401	COG0217	transcriptional regulatory protein
CH64_403	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CH64_404	COG0632	four-way junction helicase activity
CH64_405	COG2255	four-way junction helicase activity
CH64_406	COG3104	oligopeptide transport
CH64_407	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH64_408	COG1121	(ABC) transporter
CH64_409	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH64_41	COG0489	protein tyrosine kinase activity
CH64_410	COG0739	heme binding
CH64_411	COG1560	Kdo2-lipid A biosynthetic process
CH64_412	COG0469	pyruvate kinase activity
CH64_413	COG1737	Transcriptional regulator
CH64_414	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH64_415	COG0800	Aldolase
CH64_416	COG2076	Multidrug Resistance protein
CH64_417	COG2076	Multidrug Resistance protein
CH64_418	COG0251	oxidation-reduction process
CH64_419	COG1199	ATP-dependent helicase activity
CH64_421	COG3065	identical protein binding
CH64_422	COG0318	PFAM AMP-dependent synthetase and ligase
CH64_423	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH64_424	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH64_425	COG2894	cell division
CH64_426	COG0850	regulation of cytokinetic process
CH64_428	COG3100	YcgL domain-containing protein
CH64_429	COG2951	lytic endotransglycosylase activity
CH64_43	COG0572	uridine kinase
CH64_430	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH64_431	COG2983	Belongs to the UPF0260 family
CH64_434	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH64_435	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CH64_436	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH64_437	COG2186	Transcriptional regulator
CH64_438	COG2719	SpoVR family
CH64_439	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH64_44	COG0717	Belongs to the dCTP deaminase family
CH64_440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH64_442	COG2199	diguanylate cyclase activity
CH64_442	COG2202	Pas domain
CH64_442	COG2200	EAL domain
CH64_444	COG0583	DNA-binding transcription factor activity
CH64_446	COG2718	Belongs to the UPF0229 family
CH64_447	COG2766	serine protein kinase
CH64_448	COG3713	MltA-interacting MipA family protein
CH64_45	COG2982	Protein involved in outer membrane biogenesis
CH64_452	COG3139	Protein of unknown function (DUF1315)
CH64_453	COG1335	isochorismatase
CH64_454	COG0252	asparaginase activity
CH64_455	COG0616	signal peptide processing
CH64_456	COG0778	Nitroreductase
CH64_458	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH64_459	COG0494	nUDIX hydrolase
CH64_46	COG3069	C4-dicarboxylate transmembrane transporter activity
CH64_461	COG0708	Exodeoxyribonuclease III
CH64_462	COG0583	DNA-binding transcription factor activity
CH64_466	COG0788	formyltetrahydrofolate deformylase activity
CH64_467	COG3012	SEC-C Motif Domain Protein
CH64_469	COG1752	Esterase of the alpha-beta hydrolase superfamily
CH64_470	COG0745	RESPONSE REGULATOR receiver
CH64_471	COG2916	Histone family protein nucleoid-structuring protein H-NS
CH64_472	COG1435	thymidine kinase activity
CH64_473	COG1454	alcohol dehydrogenase
CH64_473	COG1012	belongs to the aldehyde dehydrogenase family
CH64_475	COG2095	MarC family integral membrane protein
CH64_478	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH64_479	COG0444	Belongs to the ABC transporter superfamily
CH64_482	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH64_483	COG2200	EAL domain
CH64_485	COG2350	Protein conserved in bacteria
CH64_486	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH64_487	COG1607	acyl-coa hydrolase
CH64_488	COG2917	probably involved in intracellular septation
CH64_491	COG3047	cAMP biosynthetic process
CH64_495	COG0159	tryptophan synthase activity
CH64_496	COG0133	tryptophan synthase activity
CH64_497	COG0134	indole-3-glycerol-phosphate synthase activity
CH64_497	COG0135	phosphoribosylanthranilate isomerase activity
CH64_499	COG0512	Glutamine amidotransferase of anthranilate synthase
CH64_5	COG0583	DNA-binding transcription factor activity
CH64_504	COG1187	pseudouridine synthase activity
CH64_507	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_508	COG0616	signal peptide processing
CH64_510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH64_511	COG0583	DNA-binding transcription factor activity
CH64_515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CH64_516	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH64_517	COG0671	phosphoesterase, PA-phosphatase related
CH64_518	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH64_519	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH64_52	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH64_522	COG0284	orotidine-5'-phosphate decarboxylase activity
CH64_523	COG0023	Translation Initiation Factor
CH64_525	COG0235	Class ii aldolase
CH64_527	COG1349	DNA-binding transcription factor activity
CH64_528	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH64_529	COG2879	small protein
CH64_530	COG1966	Carbon starvation protein
CH64_531	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CH64_532	COG0243	molybdopterin cofactor binding
CH64_533	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH64_535	COG4659	FMN binding
CH64_536	COG4658	electron transport chain
CH64_537	COG2207	Transcriptional regulator
CH64_537	COG3708	Transcriptional regulator
CH64_54	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH64_540	COG4657	Part of a membrane complex involved in electron transport
CH64_542	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CH64_544	COG2274	protein secretion by the type I secretion system
CH64_546	COG2274	protein secretion by the type I secretion system
CH64_549	COG1879	ABC-type sugar transport system periplasmic component
CH64_551	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_553	COG0673	inositol 2-dehydrogenase activity
CH64_554	COG0385	Bile acid
CH64_555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CH64_556	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH64_557	COG1263	PTS System
CH64_557	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_558	COG1609	Transcriptional regulator
CH64_559	COG5339	Protein conserved in bacteria
CH64_561	COG0114	fumarate hydratase activity
CH64_565	COG2814	Major facilitator Superfamily
CH64_566	COG0583	DNA-binding transcription factor activity
CH64_567	COG1940	carbohydrate kinase activity
CH64_568	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH64_573	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH64_574	COG1393	Belongs to the ArsC family
CH64_575	COG1742	UPF0060 membrane protein
CH64_576	COG4221	oxidoreductase activity
CH64_577	COG0477	Major facilitator Superfamily
CH64_58	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH64_580	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_588	COG0625	glutathione transferase activity
CH64_59	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH64_590	COG1522	sequence-specific DNA binding
CH64_592	COG4215	(ABC) transporter
CH64_595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH64_599	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH64_6	COG0477	Major facilitator Superfamily
CH64_60	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CH64_601	COG0028	Belongs to the TPP enzyme family
CH64_602	COG0440	acetolactate synthase activity
CH64_604	COG1011	Hydrolase
CH64_606	COG0583	DNA-binding transcription factor activity
CH64_609	COG0738	Major facilitator superfamily
CH64_61	COG0140	phosphoribosyl-ATP diphosphatase activity
CH64_61	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH64_610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH64_613	COG3121	Chaperone
CH64_617	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CH64_619	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH64_62	COG0107	imidazoleglycerol-phosphate synthase activity
CH64_620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH64_621	COG0589	response to stress
CH64_622	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH64_623	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH64_625	COG0531	amino acid
CH64_627	COG0745	RESPONSE REGULATOR receiver
CH64_628	COG2205	protein histidine kinase activity
CH64_629	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH64_63	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CH64_630	COG0659	secondary active sulfate transmembrane transporter activity
CH64_632	COG3591	Belongs to the peptidase S1B family
CH64_634	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CH64_635	COG1643	Atp-dependent helicase
CH64_636	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CH64_637	COG3784	Protein of unknown function (DUF1318)
CH64_639	COG2911	Protein conserved in bacteria
CH64_64	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CH64_641	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH64_642	COG3187	Heat shock protein
CH64_643	COG3042	response to heat
CH64_644	COG1285	pathogenesis
CH64_646	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH64_646	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH64_646	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH64_646	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_65	COG0131	Imidazoleglycerol-phosphate dehydratase
CH64_65	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH64_650	COG4166	transmembrane transport
CH64_652	COG4948	Mandelate Racemase Muconate Lactonizing
CH64_653	COG2866	Carboxypeptidase
CH64_654	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH64_658	COG3768	UPF0283 membrane protein
CH64_659	COG3106	COG3106 Predicted ATPase
CH64_66	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH64_661	COG1983	PspC domain protein
CH64_663	COG1842	Phage shock protein A
CH64_664	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH64_665	COG4166	transmembrane transport
CH64_666	COG4168	peptide transport system, permease
CH64_667	COG4171	peptide transport system, permease
CH64_669	COG4172	Belongs to the ABC transporter superfamily
CH64_67	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CH64_670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH64_670	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH64_672	COG3104	oligopeptide transport
CH64_677	COG0625	glutathione transferase activity
CH64_679	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CH64_68	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CH64_681	COG3895	Periplasmic Protein
CH64_682	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH64_683	COG3133	Outer membrane lipoprotein
CH64_684	COG1846	Transcriptional regulator
CH64_686	COG1566	PFAM secretion protein HlyD family protein
CH64_688	COG4989	oxidoreductase activity
CH64_689	COG3313	Fe-S protein
CH64_69	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH64_690	COG2194	sulfuric ester hydrolase activity
CH64_691	COG1309	transcriptional regulator
CH64_692	COG1902	pentaerythritol trinitrate reductase activity
CH64_693	COG0346	lactoylglutathione lyase activity
CH64_694	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH64_695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH64_697	COG0791	NLP P60 protein
CH64_698	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH64_7	COG0302	gtp cyclohydrolase
CH64_70	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_700	COG1609	Transcriptional regulator
CH64_701	COG0583	DNA-binding transcription factor activity
CH64_702	COG2814	Major facilitator Superfamily
CH64_703	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH64_704	COG0307	riboflavin synthase, alpha
CH64_705	COG0534	Mate efflux family protein
CH64_71	COG1129	ABC transporter
CH64_711	COG4238	major outer membrane lipoprotein
CH64_712	COG1388	LysM domain
CH64_712	COG1376	ErfK ybiS ycfS ynhG family protein
CH64_715	COG0719	Fe-S assembly protein
CH64_716	COG0396	ATPase activity
CH64_717	COG0719	Fe-S assembly protein
CH64_718	COG0316	Belongs to the HesB IscA family
CH64_719	COG2050	protein possibly involved in aromatic compounds catabolism
CH64_72	COG0371	Dehydrogenase
CH64_721	COG0277	FAD linked oxidase domain protein
CH64_721	COG0247	lactate metabolic process
CH64_722	COG0628	permease
CH64_723	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH64_723	COG0574	Belongs to the PEP-utilizing enzyme family
CH64_724	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CH64_726	COG4771	TonB-dependent receptor
CH64_727	COG3720	iron ion transport
CH64_728	COG4558	Periplasmic binding protein
CH64_730	COG0095	Lipoate-protein ligase
CH64_731	COG0791	NLP P60 protein
CH64_732	COG2076	Multidrug Resistance protein
CH64_733	COG2076	Multidrug Resistance protein
CH64_734	COG0726	polysaccharide deacetylase
CH64_737	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH64_738	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH64_739	COG0386	Belongs to the glutathione peroxidase family
CH64_74	COG0531	amino acid
CH64_740	COG4139	cobalamin transport
CH64_744	COG3122	Protein conserved in bacteria
CH64_745	COG0776	regulation of translation
CH64_749	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CH64_75	COG2925	Exonuclease
CH64_750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CH64_751	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CH64_753	COG4249	Peptidase C14 caspase catalytic subunit p20
CH64_754	COG1811	Na channel or pump
CH64_760	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH64_761	COG1121	(ABC) transporter
CH64_762	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH64_763	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH64_765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH64_765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH64_766	COG1703	isobutyryl-CoA mutase activity
CH64_767	COG1024	Enoyl-CoA hydratase
CH64_768	COG0583	DNA-binding transcription factor activity
CH64_769	COG0427	acetyl-CoA hydrolase
CH64_77	COG1289	transmembrane transporter activity
CH64_771	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH64_772	COG1917	Cupin 2, conserved barrel domain protein
CH64_773	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CH64_774	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_776	COG1175	transmembrane transport
CH64_777	COG0395	ABC-type sugar transport system, permease component
CH64_778	COG3842	ATPase activity
CH64_779	COG1653	transport
CH64_78	COG2926	Belongs to the UPF0265 family
CH64_780	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH64_781	COG1988	membrane-bound metal-dependent
CH64_783	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH64_785	COG0823	Involved in the tonB-independent uptake of proteins
CH64_786	COG2814	Major facilitator Superfamily
CH64_788	COG0501	Belongs to the peptidase M48B family
CH64_789	COG0793	Belongs to the peptidase S41A family
CH64_792	COG1956	GAF domain-containing protein
CH64_793	COG2995	paraquat-inducible protein a
CH64_794	COG3008	intermembrane lipid transfer
CH64_795	COG5001	Diguanylate cyclase
CH64_795	COG4251	negative regulation of phosphorylation
CH64_795	COG2203	Gaf domain
CH64_795	COG3706	GGDEF domain
CH64_8	COG2311	Membrane
CH64_80	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_801	COG0625	glutathione transferase activity
CH64_804	COG0786	glutamate:sodium symporter activity
CH64_82	COG1879	ABC-type sugar transport system periplasmic component
CH64_820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH64_820	COG2169	Transcriptional regulator
CH64_821	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CH64_824	COG3772	lysozyme
CH64_83	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH64_831	COG1276	copper resistance
CH64_832	COG2372	response to copper ion
CH64_833	COG1528	Iron-storage protein
CH64_836	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH64_837	COG1770	oligopeptidase
CH64_840	COG3141	response to X-ray
CH64_841	COG0513	Belongs to the DEAD box helicase family
CH64_842	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CH64_843	COG3140	Belongs to the UPF0181 family
CH64_845	COG0494	nUDIX hydrolase
CH64_846	COG1760	l-serine dehydratase
CH64_847	COG1253	flavin adenine dinucleotide binding
CH64_848	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_848	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_849	COG3715	PTS system
CH64_850	COG3716	PTS system mannose fructose sorbose family IID component
CH64_852	COG1971	Probably functions as a manganese efflux pump
CH64_855	COG2226	methyltransferase
CH64_857	COG1278	Cold shock
CH64_86	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CH64_860	COG1113	amino acid transport
CH64_868	COG2207	Transcriptional regulator
CH64_872	COG1132	(ABC) transporter
CH64_874	COG2721	sulfolactate sulfo-lyase activity
CH64_875	COG2271	Major facilitator Superfamily
CH64_876	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH64_878	COG5001	Diguanylate cyclase
CH64_878	COG2203	Gaf domain
CH64_878	COG4251	negative regulation of phosphorylation
CH64_878	COG3706	GGDEF domain
CH64_88	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CH64_880	COG3755	Protein conserved in bacteria
CH64_882	COG0697	spore germination
CH64_884	COG1733	regulation of RNA biosynthetic process
CH64_885	COG0702	epimerase
CH64_886	COG2873	o-acetylhomoserine
CH64_887	COG1566	PFAM secretion protein HlyD family protein
CH64_89	COG2241	protein methyltransferase activity
CH64_890	COG0840	transmembrane signaling receptor activity
CH64_894	COG2223	nitrite transmembrane transporter activity
CH64_898	COG0538	isocitrate dehydrogenase activity
CH64_899	COG1187	pseudouridine synthase activity
CH64_901	COG0482	sulfurtransferase activity
CH64_902	COG2915	High frequency lysogenization protein hflD homolog
CH64_903	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH64_904	COG0745	RESPONSE REGULATOR receiver
CH64_906	COG2850	peptidyl-arginine hydroxylation
CH64_908	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH64_909	COG1940	carbohydrate kinase activity
CH64_91	COG2875	Belongs to the precorrin methyltransferase family
CH64_910	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH64_912	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH64_913	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH64_914	COG3134	Outer membrane lipoprotein
CH64_915	COG1252	NADH dehydrogenase
CH64_917	COG1472	Belongs to the glycosyl hydrolase 3 family
CH64_919	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CH64_920	COG5633	Lipoprotein
CH64_921	COG0537	adenosine 5'-monophosphoramidase activity
CH64_922	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH64_924	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_924	COG1263	PTS System
CH64_925	COG0084	hydrolase, TatD family'
CH64_926	COG0470	DNA polymerase III
CH64_927	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CH64_928	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH64_929	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH64_930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH64_932	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_935	COG0416	fatty acid biosynthetic process
CH64_936	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH64_937	COG1399	metal-binding, possibly nucleic acid-binding protein
CH64_939	COG0564	pseudouridine synthase activity
CH64_941	COG1530	ribonuclease E activity
CH64_941	COG1530	ribonuclease E activity
CH64_942	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH64_943	COG0418	dihydroorotase activity
CH64_948	COG0628	permease
CH64_956	COG1560	Kdo2-lipid A biosynthetic process
CH64_957	COG2259	Doxx family
CH64_958	COG2814	Major facilitator Superfamily
CH64_959	COG3104	oligopeptide transport
CH64_961	COG5645	(Lipo)protein
CH64_962	COG2943	transferase activity, transferring hexosyl groups
CH64_963	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CH64_966	COG3263	regulation of cellular component size
CH64_967	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CH64_969	COG2771	luxR family
CH64_970	COG3916	Acyl-homoserine-lactone synthase
CH64_971	COG4235	cytochrome complex assembly
CH64_972	COG3088	subunit of a heme lyase
CH64_972	COG4235	cytochrome complex assembly
CH64_973	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH64_974	COG1138	Cytochrome C-type biogenesis protein
CH64_975	COG3301	Polysulphide reductase, NrfD
CH64_976	COG0437	4 iron, 4 sulfur cluster binding
CH64_977	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CH64_981	COG2920	part of a sulfur-relay system
CH64_982	COG1254	Belongs to the acylphosphatase family
CH64_983	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH64_984	COG3785	DNA binding
CH64_985	COG1832	CoA-binding protein
CH64_987	COG1803	Methylglyoxal synthase
CH64_988	COG0210	DNA helicase
CH64_989	COG3304	Inner membrane component domain
CH64_990	COG1289	transmembrane transporter activity
CH64_991	COG3070	regulator of competence-specific genes
CH64_992	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CH64_993	COG2885	chlorophyll binding
CH64_993	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH64_994	COG3120	sequence-specific DNA binding
CH64_995	COG1067	ATP-dependent peptidase activity
CH64_996	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH64_998	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH64_999	COG3009	Protein conserved in bacteria