locus-tag class description UGYR_00010 ENOG4105CD8 aminopeptidase N UGYR_00015 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) UGYR_00020 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) UGYR_00025 ENOG4105QVC MOSC domain-containing protein UGYR_00030 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) UGYR_00035 ENOG4105C5H ABC transporter UGYR_00040 ENOG4105F1S paraquat-inducible protein a UGYR_00045 ENOG4105DY2 Paraquat-inducible protein b UGYR_00050 ENOG4108Q2G (LipO)protein UGYR_00055 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) UGYR_00060 ENOG4105DAN ATP-dependent protease UGYR_00065 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) UGYR_00070 ENOG4105UYK outer membrane protein a UGYR_00075 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) UGYR_00080 ENOG4108RZ1 DNA transformation protein UGYR_00085 ENOG4105EM2 membrane UGYR_00090 ENOG410901E Membrane UGYR_00095 ENOG41088T4 Helicase IV UGYR_00100 ENOG4108Z5K methylglyoxal synthase UGYR_00110 ENOG4105K4P CoA-binding domain protein UGYR_00115 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) UGYR_00120 ENOG4105DR4 Methyltransferase UGYR_00125 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 UGYR_00130 ENOG4108Z0T Part of a sulfur-relay system (By similarity) UGYR_00140 ENOG4107B2H carbonic anhydrase UGYR_00160 ENOG4105DJ9 glucan biosynthesis protein UGYR_00165 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) UGYR_00175 ENOG4105DUX Transporter UGYR_00185 ENOG4105D1S lipid A biosynthesis UGYR_00195 ENOG4105DSF transport protein UGYR_00210 ENOG4105PVA Biofilm formation regulatory protein BssS UGYR_00220 ENOG4105EKE dihydroorotase UGYR_00225 ENOG41067V3 Antibiotic biosynthesis monooxygenase UGYR_00235 ENOG4107QQB Ribonuclease E UGYR_00240 ENOG4105EI2 Pseudouridine synthase UGYR_00250 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein UGYR_00255 ENOG4105VGS 50s ribosomal protein l32 UGYR_00265 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) UGYR_00270 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase UGYR_00275 ENOG4105CHR reductase UGYR_00280 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) UGYR_00285 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) UGYR_00290 ENOG4105YAZ 4-amino-4-deoxychorismate lyase UGYR_00295 ENOG4105HHA aminodeoxychorismate lyase UGYR_00300 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) UGYR_00305 ENOG4107QRG dna polymerase iii UGYR_00310 ENOG4105F8V Hydrolase, tatD family UGYR_00315 ENOG4105CI1 PTS System UGYR_00320 ENOG4105K59 histidine triad (HIT) protein UGYR_00325 ENOG41090DQ Lipoprotein UGYR_00330 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) UGYR_00335 ENOG4108RUM thiamine kinase UGYR_00345 ENOG4105D0Y UPF0227 protein UGYR_00350 ENOG4105CEP NADH dehydrogenase UGYR_00355 ENOG4107MBR 17 kDa surface antigen UGYR_00360 ENOG4108JA2 transcriptioN-repair coupling factor UGYR_00365 ENOG4105D60 lipoprotein releasing system transmembrane protein UGYR_00375 ENOG4105D60 lipoprotein releasing system transmembrane protein UGYR_00385 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) UGYR_00395 ENOG4105EZE Cupin 4 family protein UGYR_00400 ENOG4105IFJ Histidine kinase UGYR_00405 ENOG4105XJC Two component transcriptional regulator (Winged helix family UGYR_00415 ENOG4107QTF adenylosuccinate lyase UGYR_00420 ENOG41075W9 High frequency lysogenization protein HflD homolog UGYR_00425 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) UGYR_00435 ENOG4108R99 pseudouridine synthase UGYR_00440 ENOG4108HMX isocitrate dehydrogenase (NADP) UGYR_00455 ENOG4105CS2 ec 3.2.1.21 UGYR_00460 ENOG4105DGW oligopeptidase A UGYR_00475 ENOG4108MRH transcriptional regulatory protein UGYR_00480 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism UGYR_00485 ENOG4107QPK )-transporter UGYR_00525 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) UGYR_00530 ENOG4105D5M phosphate starvation-inducible protein UGYR_00535 ENOG4105EWV Sodium calcium exchanger membrane region UGYR_00540 ENOG4105Q26 Siderophore-interacting protein UGYR_00545 ENOG4105BZU Histidine kinase UGYR_00550 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii UGYR_00555 ENOG4105C4M (Ubiquinol oxidase) subunit I UGYR_00560 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family UGYR_00565 ENOG4105C8Y Acetylornithine aminotransferase UGYR_00570 ENOG4105F4X arginine UGYR_00580 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) UGYR_00600 ENOG4105CI2 imidazolone-5-propionate hydrolase UGYR_00605 ENOG4105CZE histidine utilization repressor UGYR_00610 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) UGYR_00615 ENOG41090B9 response to stress UGYR_00620 ENOG4105JQN Transcriptional regulator UGYR_00635 ENOG4105C8H hydrogenase maturation protein Hypf UGYR_00640 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) UGYR_00645 ENOG4108RC0 Electron transport protein UGYR_00650 ENOG4108MG9 hydrogenase 3 maturation protease UGYR_00655 ENOG4105I6X formate hydrogenlyase maturation UGYR_00660 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit UGYR_00665 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit UGYR_00670 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UGYR_00675 ENOG4107TDF Formate hydrogenlyase subunit 4 UGYR_00680 ENOG4107R30 NADH dehydrogenase UGYR_00685 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) UGYR_00690 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA UGYR_00695 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) UGYR_00700 ENOG4107RSS Hydrogenase accessory protein HypB UGYR_00710 ENOG4105CQS hydrogenase expression formation protein HypD UGYR_00715 ENOG4105C45 hydrogenase expression formation protein (HypE) UGYR_00760 ENOG4105C3G gtp-binding protein UGYR_00770 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) UGYR_00775 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria UGYR_00780 ENOG4105C5T Phosphoribosyl pyrophosphate synthase UGYR_00790 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) UGYR_00795 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) UGYR_00800 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) UGYR_00805 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) UGYR_00810 ENOG4108YY7 Invasion gene expression up-regulator SirB UGYR_00815 ENOG41063JG Transcriptional regulator UGYR_00820 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase UGYR_00825 ENOG4105CHH sulfate transporter UGYR_00840 ENOG4105BZU Histidine kinase UGYR_00860 ENOG4105DUX Transporter UGYR_00865 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase UGYR_00875 ENOG4107XHZ cytoplasmic chaperone TorD family protein UGYR_00880 ENOG4105F3T (LipO)protein UGYR_00895 ENOG4105D9U N-acetyltransferase UGYR_00905 ENOG4105EP9 oxidoreductase UGYR_00910 ENOG4105CJR Integral membrane protein (MviN UGYR_00935 ENOG4106ZCM YecM protein UGYR_00940 ENOG4106N3A copper homeostasis protein cutc UGYR_00955 ENOG4105WJG Glutathione UGYR_00960 ENOG41081XQ Conserved Protein UGYR_00970 ENOG4105C9M aspartyl-trna synthetase UGYR_00975 ENOG4108TIT dATP pyrophosphohydrolase UGYR_00985 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) UGYR_00995 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) UGYR_01000 ENOG4105DUX Transporter UGYR_01005 ENOG4105FAV ABC, transporter UGYR_01010 ENOG4105FDK ABC transporter UGYR_01015 ENOG4105NXV High-affinity zinc uptake system protein UGYR_01020 ENOG4105DR5 peptidase UGYR_01025 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase UGYR_01030 ENOG4105CA9 Pyruvate kinase UGYR_01035 ENOG4106KNT transcriptional regulator UGYR_01040 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase UGYR_01045 ENOG4108UHU Aldolase UGYR_01060 ENOG4105M4H endoribonuclease L-psp UGYR_01065 ENOG4105DVT helicase UGYR_01070 ENOG41072GX Peptidase M22 Glycoprotease UGYR_01075 ENOG4105Y4Z Outer Membrane Lipoprotein UGYR_01080 ENOG4105CEY Amp-dependent synthetase and ligase UGYR_01085 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) UGYR_01090 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) UGYR_01095 ENOG4107QMS site-determining protein UGYR_01100 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) UGYR_01105 ENOG4105VNG YcgL domain-containing protein UGYR_01110 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase UGYR_01115 ENOG4108ZZ3 UPF0260 protein UGYR_01130 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) UGYR_01140 ENOG4105ED1 spovr family UGYR_01145 ENOG4105MWK D-amino acid dehydrogenase, small subunit UGYR_01150 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) UGYR_01165 ENOG4105BZU Histidine kinase UGYR_01180 ENOG4105C7K acetolactate synthase UGYR_01185 ENOG4106AKX UPF0229 protein UGYR_01190 ENOG4105CYN Serine protein kinase UGYR_01195 ENOG4105GNX MltA-interacting MipA family protein UGYR_01205 ENOG4105DSB aldose 1-epimerase UGYR_01215 ENOG4105E0X reductase UGYR_01220 ENOG4105VUT cytoplasmic protein UGYR_01225 ENOG4108RWI nicotinamidase UGYR_01230 ENOG4105HDK L-asparaginase UGYR_01235 ENOG4105D07 Signal peptide peptidase, SppA UGYR_01240 ENOG41069NU Nitroreductase UGYR_01250 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) UGYR_01255 ENOG4105MTM Protein of unknown function (DUF1496) UGYR_01260 ENOG4105M6F mutator MutT protein UGYR_01265 ENOG4105CGK Exodeoxyribonuclease III UGYR_01295 ENOG4105CIY formyltetrahydrofolate deformylase UGYR_01305 ENOG4105D78 K07001 NTE family protein UGYR_01310 ENOG4105I93 response regulator UGYR_01315 ENOG4105C6Y Udp-glucose 6-dehydrogenase UGYR_01325 ENOG4107104 thymidine kinase UGYR_01330 ENOG4108EKI Dehydrogenase UGYR_01335 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein UGYR_01345 ENOG4108J59 Extracellular solute-binding protein, family 5 UGYR_01350 ENOG4107QSI ABC, transporter UGYR_01355 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component UGYR_01360 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UGYR_01365 ENOG4105C3U ABC transporter UGYR_01370 ENOG4108JQ7 (ABC) transporter UGYR_01375 ENOG4108W5H UPF0263 protein UGYR_01380 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) UGYR_01400 ENOG4105K9H YciI-like protein UGYR_01450 ENOG410822N TonB family UGYR_01455 ENOG4105NAU thioesterase Superfamily protein UGYR_01470 ENOG4108S3I UPF0259 membrane protein UGYR_01475 ENOG4105PI0 Ferredoxin UGYR_01480 ENOG4105EIF outer membrane protein W UGYR_01495 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) UGYR_01500 ENOG4105DK0 Indole-3-glycerol phosphate synthase UGYR_01510 ENOG4105DDQ anthranilate synthase UGYR_01520 ENOG4105DB7 PHP domain protein UGYR_01525 ENOG4107RTD sua5 ycio yrdc ywlc family protein UGYR_01530 ENOG4105FE9 pseudouridine synthase UGYR_01535 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase UGYR_01540 ENOG4105UBK short-chain dehydrogenase reductase UGYR_01545 ENOG4105ERU peptidase UGYR_01550 ENOG4105RKX Protein of unknown function (DUF2498) UGYR_01555 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) UGYR_01560 ENOG4107R11 Transcriptional regulator UGYR_01575 ENOG4107QM5 aconitate hydratase UGYR_01580 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) UGYR_01585 ENOG4105EYK Phosphatidylglycerophosphatase B UGYR_01590 ENOG4105Q4A inner membrane protein yciS UGYR_01595 ENOG4105CFV Tetratricopeptide repeat protein UGYR_01605 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction UGYR_01615 ENOG4108ZJT translation initiation factor, Sui1 UGYR_01620 ENOG41061RM osmotically inducible lipoprotein UGYR_01625 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) UGYR_01630 ENOG4105BZU Histidine kinase UGYR_01635 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) UGYR_01640 ENOG4105CSM endonuclease III UGYR_01650 ENOG4108UQQ Electron transport complex UGYR_01660 ENOG4105UEI Transcriptional Regulator AraC Family UGYR_01675 ENOG4105DGN Electron transport complex UGYR_01680 ENOG4105M9B inner membrane protein ydgK UGYR_01685 ENOG4105CKU formyltetrahydrofolate synthetase UGYR_01695 ENOG4105D9R oxidoreductase UGYR_01700 ENOG4105DHU Bile acid UGYR_01705 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) UGYR_01710 ENOG4106J39 exported protein UGYR_01715 ENOG4105EIP mannose-6-phosphate isomerase UGYR_01720 ENOG4105C9Q fumarate hydratase class II UGYR_01725 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) UGYR_01730 ENOG4105DAG ROK family UGYR_01735 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) UGYR_01745 ENOG4105KBG Protein of unknown function (DUF1161) UGYR_01750 ENOG4105M5Q UPF0482 protein UGYR_01755 ENOG4105KK4 UPF0060 membrane protein UGYR_01760 ENOG4105EMU Dehydrogenase UGYR_01765 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase UGYR_01785 ENOG4105FYV Amp nucleosidase UGYR_01825 ENOG4105PAD Hydrolase UGYR_01835 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) UGYR_01840 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) UGYR_01845 ENOG4105DS0 Transcriptional regulator, Crp Fnr family UGYR_01850 ENOG4105Q9Y Universal stress protein UGYR_01875 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase UGYR_01885 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase UGYR_01890 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) UGYR_01895 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) UGYR_01900 ENOG4105C5D exported protein UGYR_01905 ENOG4105D5Q Arginine ornithine antiporter UGYR_01915 ENOG4107EXC regulatoR UGYR_01920 ENOG4105JJR Histidine kinase UGYR_01925 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) UGYR_01935 ENOG4108UQN AraC family transcriptional regulator UGYR_01940 ENOG4108V1U phospholipid-binding protein UGYR_01950 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap UGYR_01955 ENOG4105CQ7 ATP-dependent helicase UGYR_01965 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) UGYR_01970 ENOG4105WXT Conserved Protein UGYR_01975 ENOG410689M (LipO)protein UGYR_01985 ENOG4107H52 Dicarboxylate transport UGYR_01990 ENOG4105C5I Dehydrogenase UGYR_01995 ENOG41090X5 Heat shock protein hslJ UGYR_02005 ENOG4105KT7 mgtC SapB transporter UGYR_02015 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) UGYR_02020 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) UGYR_02030 ENOG4107QSI ABC, transporter UGYR_02035 ENOG4105KXI murein peptide amidase A UGYR_02040 ENOG4107S8C mandelate racemase muconate lactonizing UGYR_02045 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) UGYR_02065 ENOG4106K28 UPF0283 membrane protein UGYR_02070 ENOG4105CM6 amino acid regulated cytosolic protein UGYR_02075 ENOG4105NNG Peripheral inner membrane phage-shock protein UGYR_02080 ENOG4105FM1 phage shock protein C UGYR_02085 ENOG4105YYT phage shock protein B UGYR_02090 ENOG41087YS Phage shock protein A UGYR_02095 ENOG4105E51 psp operon transcriptional activator UGYR_02105 ENOG4106DF6 pertussis toxin subunit 1 UGYR_02115 ENOG4108HIY periplasmic UGYR_02120 ENOG4108I5W peptide transport system, permease protein UGYR_02125 ENOG4108EU3 peptide transport system, permease UGYR_02130 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein UGYR_02135 ENOG4108JQ2 peptide transport system atp-binding protein UGYR_02140 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH UGYR_02145 ENOG4105DUX Transporter UGYR_02150 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) UGYR_02155 ENOG4105DVC DnaJ domain protein UGYR_02165 ENOG41069YE inner membrane protein yohC UGYR_02175 ENOG4108ZR5 Conserved Protein UGYR_02180 ENOG4108K3A Glutathione S-transferase UGYR_02200 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) UGYR_02205 ENOG4108XTF Outer Membrane Lipoprotein UGYR_02210 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) UGYR_02215 ENOG4107RGM aldo keto reductase UGYR_02220 ENOG4105XZD Fe-S protein UGYR_02225 ENOG4105DIJ Phosphoethanolamine transferase UGYR_02230 ENOG4108WUH Transcriptional regulator, TetR family UGYR_02235 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase UGYR_02240 ENOG4108UYE Lactoylglutathione lyase UGYR_02250 ENOG4105M2J Glutaredoxin UGYR_02255 ENOG4105K4H Nlp p60 protein UGYR_02260 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) UGYR_02265 ENOG4105ETE Transcriptional regulator (LacI family UGYR_02270 ENOG4105F52 Transcriptional regulator UGYR_02275 ENOG4105CZQ inner membrane transport protein YdhC UGYR_02280 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase UGYR_02285 ENOG4108R6K riboflavin synthase, subunit alpha UGYR_02315 ENOG4105CA9 Pyruvate kinase UGYR_02320 ENOG4105KMX major outer membrane lipoprotein UGYR_02325 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein UGYR_02330 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) UGYR_02340 ENOG4105JRK feS assembly protein SufD UGYR_02345 ENOG4105C3K feS assembly ATPase SufC UGYR_02350 ENOG4105DIW FeS assembly protein SUFB UGYR_02355 ENOG4108Z4V iron-sulfur cluster assembly UGYR_02360 ENOG4105KA0 thioesterase Superfamily protein UGYR_02365 ENOG4105CQB FAD linked oxidase domain protein UGYR_02370 ENOG4105IPI Membrane UGYR_02375 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) UGYR_02380 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) UGYR_02385 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) UGYR_02390 ENOG4107ENK receptor UGYR_02395 ENOG4106QJH hemin transport protein UGYR_02400 ENOG4107R4I Periplasmic binding protein UGYR_02405 ENOG4105EHG Permease protein UGYR_02410 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) UGYR_02420 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) UGYR_02425 ENOG4108QBX (LipO)protein UGYR_02430 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) UGYR_02435 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) UGYR_02440 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) UGYR_02455 ENOG4105CKK Glycosyl transferase, family 2 UGYR_02460 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase UGYR_02465 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) UGYR_02470 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) UGYR_02510 ENOG4105ZTC transcriptional activator, Ogr delta UGYR_02515 ENOG4105YB8 TM2 domain containing protein UGYR_02520 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) UGYR_02585 ENOG41082NP Multiple antibiotic resistance UGYR_02590 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division UGYR_02595 ENOG4105DSE periplasmic solute binding protein UGYR_02600 ENOG4105DIK (ABC) transporter UGYR_02605 ENOG4105CC5 ABC transporter UGYR_02610 ENOG4105CC5 ABC transporter UGYR_02615 ENOG4105FGM Fructosamine kinase UGYR_02620 ENOG4107PN8 YfeABCD locus regulator UGYR_02625 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 UGYR_02630 ENOG4107K5X Membrane-bound metal-dependent hydrolase UGYR_02635 ENOG4108ETY sodium dicarboxylate symporter UGYR_02640 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase UGYR_02650 ENOG4105C0R drug resistance transporter emrb qaca subfamily UGYR_02655 ENOG4105D0M Protease HtpX homolog UGYR_02660 ENOG4105CN1 protease UGYR_02670 ENOG4108ZGC gaf domain protein UGYR_02675 ENOG4105H2K paraquat-inducible protein a UGYR_02680 ENOG4105DY2 Paraquat-inducible protein b UGYR_02690 ENOG4105WT8 Protein of unknown function (DUF1480) UGYR_02705 ENOG4107Y60 (LipO)protein UGYR_02715 ENOG4106B0W Curli production assembly transport component CsgG UGYR_02785 ENOG4105VZ1 Replication Protein UGYR_02800 ENOG4105ED4 portal protein UGYR_02895 ENOG4108US3 tail fiber assembly UGYR_02935 ENOG4105ZTC transcriptional activator, Ogr delta UGYR_02940 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) UGYR_02945 ENOG4105NKT exported protein UGYR_02950 ENOG4108PNC copper resistance UGYR_02955 ENOG4105FXM Copper resistance protein UGYR_02960 ENOG41090A1 ferritin UGYR_02965 ENOG4105MPK DNA polymerase III subunit theta UGYR_02975 ENOG4105UMD exodeoxyribonuclease X UGYR_02980 ENOG4105CUG Oligopeptidase b UGYR_02990 ENOG4105N5Z UPF0267 protein UGYR_02995 ENOG4105X2V dna damage-inducible protein UGYR_03000 ENOG4105C1J atp-dependent rna helicase UGYR_03020 ENOG4105P8F nudix hydrolase UGYR_03025 ENOG4105EJQ L-serine dehydratase UGYR_03030 ENOG4105EE5 Membrane protein terC UGYR_03035 ENOG4108EQA pts system UGYR_03040 ENOG4105ETZ PTS System UGYR_03045 ENOG4105F3R pts system mannose fructose sorbose family iid UGYR_03050 ENOG4108NK4 UPF0266 membrane protein UGYR_03055 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) UGYR_03075 ENOG4105C1G acyl-Coa dehydrogenase UGYR_03085 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) UGYR_03115 ENOG4105DHI Methyltransferase UGYR_03120 ENOG4105CJN penicillin-binding protein UGYR_03125 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase UGYR_03130 ENOG4105VEQ Cold shock protein UGYR_03135 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) UGYR_03140 ENOG4105C85 amino acid UGYR_03155 ENOG41064PC UGYR_03170 ENOG4105N4N Protein of unknown function (DUF2766) UGYR_03190 ENOG4105D5Q Arginine ornithine antiporter UGYR_03195 ENOG4105BZ1 (ABC) transporter UGYR_03220 ENOG4105XXV Acid-resistance protein UGYR_03225 ENOG4105CPF Cell wall formation (By similarity) UGYR_03245 ENOG4105VEQ Cold shock protein UGYR_03250 ENOG4105VEQ Cold shock protein UGYR_03265 ENOG4105EZV Transcriptional regulator UGYR_03270 ENOG4105VCP PTS System UGYR_03275 ENOG4105CS2 ec 3.2.1.21 UGYR_03280 ENOG4105CK1 PTS System UGYR_03285 ENOG4105VZJ PTS System UGYR_03295 ENOG4105FE9 pseudouridine synthase UGYR_03305 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme UGYR_03310 ENOG4105DFD Na H antiporter UGYR_03320 ENOG4105D5Q Arginine ornithine antiporter UGYR_03325 ENOG4105CEU Arginine dihydrolase UGYR_03335 ENOG4105D3G Pseudouridine synthase UGYR_03340 ENOG4105CVK Glutamate decarboxylase UGYR_03345 ENOG4105E5D amino acid UGYR_03350 ENOG4105CSV Glutaminase UGYR_03380 ENOG4107YB6 acetyltransferase, (GNAT) family UGYR_03415 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) UGYR_03425 ENOG4105C8Q Methyl-accepting chemotaxis UGYR_03450 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase UGYR_03455 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) UGYR_03460 ENOG4105WH1 Two component transcriptional regulator luxr family UGYR_03465 ENOG4105XVG cytoplasmic protein UGYR_03485 ENOG4105CXN decarboxylase UGYR_03490 ENOG4105D5Q Arginine ornithine antiporter UGYR_03495 ENOG4108M3R transcriptional activator CadC UGYR_03500 ENOG4105CK7 Sodium proline symporter UGYR_03505 ENOG4105C26 Dehydrogenase UGYR_03510 ENOG4105CDA abc transporter atp-binding protein UGYR_03515 ENOG4105E5Q amino acid AbC transporter UGYR_03520 ENOG4105EAB amino acid AbC transporter UGYR_03525 ENOG4105K6H D-cysteine desulfhydrase UGYR_03530 ENOG4108M9K flagella biosynthesis protein FliZ UGYR_03535 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) UGYR_03540 ENOG4105I03 Flagellin UGYR_03555 ENOG4105DTS flagellar hook-associated UGYR_03560 ENOG4105MQ3 flagellar protein FliS UGYR_03565 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) UGYR_03575 ENOG4105DHT Metal Dependent Phosphohydrolase UGYR_03580 ENOG4107SVH Potassium channel protein UGYR_03595 ENOG4105VQ0 flagellar hook-basal body complex protein fliE UGYR_03600 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) UGYR_03605 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) UGYR_03610 ENOG41090PJ Flagellar assembly protein UGYR_03615 ENOG4108JIR Flagellum-specific ATP synthase UGYR_03620 ENOG4105GSA Flagellar export protein flij UGYR_03625 ENOG4105WF4 Flagellar hook-length control protein UGYR_03630 ENOG4107ZI8 flagellar basal body-associated protein flil UGYR_03635 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) UGYR_03640 ENOG4105DD5 Flagellar motor switch protein UGYR_03650 ENOG4105CN7 Flagellar biosynthetic protein FliP UGYR_03655 ENOG4105VS8 Flagellar biosynthetic protein fliq UGYR_03660 ENOG4105D19 Role in flagellar biosynthesis (By similarity) UGYR_03665 ENOG4105DTJ flagellar hook-associated protein UGYR_03670 ENOG4105E1Q flagellar hook-associated protein UGYR_03675 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj UGYR_03690 ENOG4105CGA flagellar basal-body rod protein FlgG UGYR_03695 ENOG4108KPB Flagellar basal-body rod protein FlgF UGYR_03700 ENOG4105BZE flagellar hook protein, FlgE UGYR_03705 ENOG4105W00 Flagellar hook capping protein UGYR_03710 ENOG4108ZC9 flagellar basal-body rod protein flgc UGYR_03720 ENOG4105CKS Flagella basal body P-ring formation protein flgA UGYR_03725 ENOG4105M9M anti-sigma28 factor FlgM UGYR_03730 ENOG4105QVD Flagella synthesis protein FlgN UGYR_03740 ENOG4105W13 flagellar protein UGYR_03745 ENOG4105D7B Flagellar biosynthesis protein flha UGYR_03750 ENOG4105D00 flagellar biosynthetic protein flhB UGYR_03755 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin UGYR_03760 ENOG4108N8T regulatoR UGYR_03780 ENOG4106PG1 outer membrane usher protein UGYR_03785 ENOG4108FZ9 Chaperone UGYR_03795 ENOG4105UGQ Fimbrial UGYR_03825 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) UGYR_03830 ENOG4108VYJ response regulator receiver protein UGYR_03840 ENOG4105BZU Histidine kinase UGYR_03845 ENOG4105C8Q Methyl-accepting chemotaxis UGYR_03850 ENOG4105C8Q Methyl-accepting chemotaxis UGYR_03855 ENOG4108V3W Chemotaxis protein, CheW UGYR_03860 ENOG4105CBS Chea signal transduction histidine kinase UGYR_03865 ENOG4105ER2 Ompa motb domain protein UGYR_03870 ENOG4107RD7 Flagellar Motor Protein, MotA UGYR_03875 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region UGYR_03880 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) UGYR_03890 ENOG4108VA4 Universal stress protein UGYR_03895 ENOG4105KT7 mgtC SapB transporter UGYR_03900 ENOG4105C8Q Methyl-accepting chemotaxis UGYR_03905 ENOG4105VZF DsrB protein UGYR_03910 ENOG4105VEQ Cold shock protein UGYR_03920 ENOG4105ETE Transcriptional regulator (LacI family UGYR_03935 ENOG4105GSJ Inner membrane protein ylaC UGYR_03945 ENOG41061EV selenium-binding protein YdfZ UGYR_03975 ENOG4107QPK )-transporter UGYR_03990 ENOG4105CHY citrate lyase, alpha UGYR_03995 ENOG4105CI0 Citrate lyase UGYR_04000 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) UGYR_04005 ENOG4105DUA (citrate (pro-3S)-lyase ligase UGYR_04010 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism UGYR_04015 ENOG4106YYS transcriptional regulatory protein UGYR_04020 ENOG4108KX4 response regulator UGYR_04025 ENOG4105BZU Histidine kinase UGYR_04030 ENOG4105CXY transporter UGYR_04035 ENOG4105C4Y ABC transporter UGYR_04040 ENOG4107RCV ABC transporter, permease UGYR_04045 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) UGYR_04065 ENOG4105DR8 Membrane UGYR_04075 ENOG4105CJB Exodeoxyribonuclease I UGYR_04080 ENOG4105CUB amino acid UGYR_04085 ENOG4105D05 Receptor UGYR_04095 ENOG4105EHG Permease protein UGYR_04105 ENOG4108IQI permease UGYR_04110 ENOG4105DUM transcriptional regulator, lysR family UGYR_04125 ENOG4105HMI Membrane UGYR_04130 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) UGYR_04135 ENOG4105DM4 PTS System UGYR_04140 ENOG4105DE4 1-phosphofructokinase UGYR_04145 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein UGYR_04155 ENOG4105CUW cytochrome C-TYPE protein UGYR_04160 ENOG4107QY8 reductase UGYR_04165 ENOG4105KRS Proteinase inhibitor UGYR_04175 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) UGYR_04180 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) UGYR_04185 ENOG4105DEI Mannitol dehydrogenase UGYR_04195 ENOG4105CKI cobalamin synthesis protein UGYR_04200 ENOG41076MN Phosphoesterase, PA-phosphatase related UGYR_04205 ENOG4107TT5 NLP P60 protein UGYR_04210 ENOG4105CXC rtn protein UGYR_04215 ENOG4105E43 Extracellular solute-binding protein, family 5 UGYR_04220 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component UGYR_04225 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component UGYR_04230 ENOG4108JQ5 ABC transporter UGYR_04235 ENOG4105HG6 UGYR_04240 ENOG4105C2C drug resistance transporter, Bcr CflA UGYR_04245 ENOG4105I08 Pseudouridine synthase UGYR_04265 ENOG4105PAN UPF0352 protein UGYR_04275 ENOG4105E68 Sulfatase UGYR_04280 ENOG4105E68 Sulfatase UGYR_04295 ENOG4108C33 Resolvase UGYR_04300 ENOG4105PTU response to oxidative stress UGYR_04305 ENOG4105PTU response to oxidative stress UGYR_04310 ENOG4105Y9F tail fiber protein UGYR_04315 ENOG4105Y0G tail protein UGYR_04320 ENOG4108T86 baseplate J family protein UGYR_04365 ENOG4105TKZ Tail Sheath UGYR_04405 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) UGYR_04415 ENOG4105CAR Terminase, large subunit UGYR_04430 ENOG4106050 phage regulatory protein, rha family UGYR_04435 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 UGYR_04465 ENOG4108MXB Protein of unknown function (DUF968) UGYR_04495 ENOG4105CAR Terminase, large subunit UGYR_04540 ENOG4105H40 UGYR_04545 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) UGYR_04550 ENOG4108R7K Metal Dependent Phosphohydrolase UGYR_04575 ENOG4105Y50 Virulence Protein UGYR_04585 ENOG4107R6D beta-lactam binding protein AmpH UGYR_04590 ENOG4105D9U N-acetyltransferase UGYR_04610 ENOG4106UW1 Major Facilitator superfamily UGYR_04615 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC UGYR_04620 ENOG41068CG regulatoR UGYR_04625 ENOG4105BZU Histidine kinase UGYR_04630 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) UGYR_04635 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) UGYR_04640 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) UGYR_04645 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) UGYR_04650 ENOG4105XPH Ferredoxin UGYR_04660 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) UGYR_04670 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) UGYR_04675 ENOG4105CKK Glycosyl transferase, family 2 UGYR_04685 ENOG4105E0U tyrosine-specific transport protein UGYR_04690 ENOG4108UII YfaZ family UGYR_04695 ENOG4105CH6 catalase UGYR_04700 ENOG4105CEY Amp-dependent synthetase and ligase UGYR_04710 ENOG4108IPT Naphthoate synthase UGYR_04715 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) UGYR_04720 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) UGYR_04725 ENOG4105E4F Isochorismate synthase UGYR_04730 ENOG4105TNS Conserved Protein UGYR_04735 ENOG4108UQ5 membrane protein YcdZ UGYR_04745 ENOG4105C8S subunit m UGYR_04750 ENOG4105D65 subunit l UGYR_04760 ENOG4107UFS subunit j UGYR_04765 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UGYR_04770 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) UGYR_04775 ENOG4108IEH NADH dehydrogenase subunit g UGYR_04780 ENOG4107QIZ NADH dehydrogenase UGYR_04785 ENOG4105GKE subunit e UGYR_04795 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UGYR_04800 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain UGYR_04805 ENOG4107NQ8 LysR family Transcriptional regulator UGYR_04815 ENOG4105CHM Aminotransferase UGYR_04820 ENOG4105DK2 UPF0207 protein UGYR_04825 ENOG4107QWE )-transporter UGYR_04835 ENOG4105XWI UPF0304 protein UGYR_04840 ENOG4105PQ6 UPF0208 membrane protein UGYR_04850 ENOG4105C6K Malic enzyme UGYR_04855 ENOG4105DIQ Transcriptional regulator UGYR_04870 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC UGYR_04875 ENOG4105PTV Nudix Hydrolase UGYR_04880 ENOG4108RE9 Phosphodiesterase UGYR_04890 ENOG4105CYM Glutathione S-transferase UGYR_04895 ENOG4105ECP epimerase UGYR_04900 ENOG4108JEH abc transporter atp-binding protein UGYR_04905 ENOG4106YG3 ABC transporter UGYR_04910 ENOG4105DSP amino acid AbC transporter UGYR_04915 ENOG4105E89 ABC transporter UGYR_04920 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UGYR_04925 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase UGYR_04930 ENOG4105E96 Colicin v production protein UGYR_04935 ENOG4108S3P Sporulation domain protein UGYR_04940 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase UGYR_04950 ENOG4105DQR SNARE associated Golgi UGYR_04960 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) UGYR_04985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family UGYR_04990 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen UGYR_05020 ENOG4106WZ1 flagella biosynthesis regulator UGYR_05030 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) UGYR_05040 ENOG4105MH2 YfcL protein UGYR_05045 ENOG4108BPE -transporting atpase UGYR_05050 ENOG4105EJ9 Membrane UGYR_05055 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) UGYR_05065 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) UGYR_05070 ENOG4108DG9 Smr protein MutS2 UGYR_05075 ENOG4108BY2 phosphohistidine phosphatase UGYR_05080 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase UGYR_05085 ENOG4105CHU acetyl-coa acetyltransferase UGYR_05090 ENOG4105KZW UPF0381 protein UGYR_05095 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation UGYR_05100 ENOG410903C (LipO)protein UGYR_05105 ENOG4105KWW Biogenesis protein UGYR_05110 ENOG4105KWW Biogenesis protein UGYR_05115 ENOG4107QX9 Thiol disulfide interChange protein UGYR_05120 ENOG4105DA4 cytochrome c-type biogenesis protein UGYR_05125 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) UGYR_05130 ENOG4105X3C heme exporter protein UGYR_05135 ENOG41060IM Heme exporter protein UGYR_05140 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) UGYR_05160 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA UGYR_05165 ENOG4105CVE Lytic murein transglycosylase UGYR_05170 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin UGYR_05175 ENOG4108VKM cytochrome b561 UGYR_05180 ENOG4105CHM Aminotransferase UGYR_05185 ENOG41072TH Protein of unknown function (DUF1479) UGYR_05190 ENOG4108HRK Histidine kinase UGYR_05195 ENOG4105DY9 regulatoR UGYR_05200 ENOG4105FCD Major Facilitator UGYR_05205 ENOG4105CHC glucokinase (EC 2.7.1.2) UGYR_05215 ENOG4105C5Q Transcriptional regulator UGYR_05225 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) UGYR_05230 ENOG4105D9N nucleoside UGYR_05295 ENOG4105VRT cytoplasmic protein UGYR_05300 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) UGYR_05310 ENOG4105EXN Sulfate transport protein CysZ UGYR_05315 ENOG4105C6T cysteine synthase UGYR_05320 ENOG4105KZ7 phosphocarrier protein hpr UGYR_05330 ENOG4105C5Y PTS System UGYR_05335 ENOG4105C6T cysteine synthase UGYR_05345 ENOG4105ECW sulfate abc transporter UGYR_05350 ENOG4108I5D sulfate abc transporter UGYR_05365 ENOG4105QEK Transcriptional regulator UGYR_05370 ENOG4108R66 Conserved Protein UGYR_05390 ENOG4105EZR dyp-type peroxidase family protein UGYR_05395 ENOG4105E7K (LipO)protein UGYR_05400 ENOG4105H4F exported protein UGYR_05415 ENOG4108UPT UPF0178 protein UGYR_05420 ENOG4105C6K Malic enzyme UGYR_05425 ENOG4107VIJ nudix hydrolase UGYR_05430 ENOG4105CUW cytochrome C-TYPE protein UGYR_05435 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) UGYR_05440 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) UGYR_05445 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase UGYR_05450 ENOG4108ZNS ferredoxin-type protein NapF UGYR_05460 ENOG4105WH1 Two component transcriptional regulator luxr family UGYR_05470 ENOG4105BZS acriflavin resistance protein UGYR_05480 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) UGYR_05485 ENOG4105KUZ arsenate reductase UGYR_05490 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) UGYR_05500 ENOG4105XYK UPF0370 protein UGYR_05505 ENOG4106KED esterase YpfH UGYR_05525 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) UGYR_05530 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) UGYR_05535 ENOG4105RH4 Glycine cleavage system transcriptional repressor UGYR_05540 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen UGYR_05545 ENOG4105C02 permease UGYR_05550 ENOG4105ERG peptidase m48, ste24p UGYR_05555 ENOG4105K89 arsenate reductase UGYR_05560 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) UGYR_05565 ENOG4105C2W permease UGYR_05570 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) UGYR_05575 ENOG4105CXB phosphoribosylaminoimidazole synthetase UGYR_05580 ENOG4108V3E phosphoribosylglycinamide formyltransferase UGYR_05585 ENOG4108MK9 spermidine N(1)-acetyltransferase UGYR_05595 ENOG4105E2Z phosphate ABC transporter (Permease UGYR_05600 ENOG4105C8U phosphate abc transporter UGYR_05610 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) UGYR_05615 ENOG4105C9X ppx gppa phosphatase UGYR_05625 ENOG4105CJW magnesium transporter UGYR_05630 ENOG4105R8A Heat shock protein UGYR_05640 ENOG4108VCD Chaperone UGYR_05645 ENOG4105CW0 outer membrane usher protein UGYR_05660 ENOG4105ENT Efflux transporter rnd family, mfp subunit UGYR_05670 ENOG4105BZS acriflavin resistance protein UGYR_05675 ENOG4105C0R drug resistance transporter emrb qaca subfamily UGYR_05680 ENOG4105EB3 Histidine kinase UGYR_05685 ENOG4105E3W Two component transcriptional regulator (Winged helix family UGYR_05690 ENOG4105KWI UPF0339 protein UGYR_05695 ENOG4105CFP Peptidase U32 UGYR_05700 ENOG4107TE5 Lipid kinase UGYR_05705 ENOG4108ZGU inhibitor of vertebrate lysozyme UGYR_05715 ENOG4105DWF phosphomethylpyrimidine kinase UGYR_05800 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) UGYR_05805 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) UGYR_05810 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) UGYR_05820 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) UGYR_05825 ENOG4105N21 Membrane UGYR_05830 ENOG4105CUT histidyl-tRNA synthetase UGYR_05865 ENOG4108JQB penicillin-binding protein 1C UGYR_05870 ENOG4105DN3 alpha-2-macroglobulin domain protein UGYR_05875 ENOG4105YYA enhanced serine sensitivity protein SseB UGYR_05885 ENOG4105WVQ Fe-S assembly protein IscX UGYR_05890 ENOG4108ZIT Ferredoxin, 2FE-2S UGYR_05895 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB UGYR_05910 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins UGYR_05915 ENOG4105C3J Cysteine desulfurase UGYR_05920 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family UGYR_05925 ENOG4105CVS RNA methyltransferase TrmH family, group 1 UGYR_05930 ENOG4105ECY inositol monophosphatase UGYR_05935 ENOG4105D7X high-affinity nickel-transporter UGYR_05940 ENOG41065CD Exported protein UGYR_05945 ENOG4108MN2 Stationary phase inducible protein CsiE UGYR_05950 ENOG4105D8G Major Facilitator superfamily UGYR_05960 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) UGYR_05965 ENOG4108M21 UGYR_05970 ENOG4105RMW regulation of transcription, DNA-dependent UGYR_05975 ENOG4108626 Racemase UGYR_05980 ENOG41080QX K07048 phosphotriesterase-related protein UGYR_05985 ENOG4105MUZ Protein of unknown function DUF2620 UGYR_05990 ENOG4106M0N transport system permease protein UGYR_05995 ENOG4108YZA Nitrogen regulatory protein pii UGYR_06000 ENOG4105C4K Nad synthetase UGYR_06005 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family UGYR_06010 ENOG4108SKK alpha helix protein UGYR_06015 ENOG4107WP9 Histidine kinase UGYR_06035 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) UGYR_06040 ENOG4108Z6B deaminase UGYR_06045 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB UGYR_06060 ENOG4106G6Q Transcriptional regulator UGYR_06065 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding UGYR_06075 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) UGYR_06085 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) UGYR_06095 ENOG4105C3F Signal peptidase i UGYR_06100 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) UGYR_06105 ENOG4105WMJ Positive regulator of sigma E, RseC MucC UGYR_06115 ENOG41069PW sigma-e factor negative regulatory protein UGYR_06125 ENOG4108IYU L-aspartate oxidase UGYR_06135 ENOG4105C1J atp-dependent rna helicase UGYR_06150 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) UGYR_06160 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ UGYR_06165 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) UGYR_06170 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) UGYR_06175 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) UGYR_06180 ENOG4105VDB UPF0125 protein UGYR_06185 ENOG4108Z1B Cyclase dehydrase UGYR_06190 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) UGYR_06195 ENOG4105DFP Integrase UGYR_06225 ENOG4105M03 Domain of unknown function (DUF955) UGYR_06235 ENOG4108MXD gtp-binding protein UGYR_06255 ENOG4107UNZ domain protein UGYR_06265 ENOG4105DFP Integrase UGYR_06280 ENOG4108NAE Fimbrial chaperone protein UGYR_06285 ENOG4105CW0 outer membrane usher protein UGYR_06345 ENOG4105C2X Arabinose 5-phosphate isomerase UGYR_06350 ENOG4105EF1 ribulokinase UGYR_06360 ENOG4105CNN ABC, transporter UGYR_06365 ENOG4105C2J ABC transporter UGYR_06375 ENOG4107U2T alpha beta UGYR_06380 ENOG4105JQN Transcriptional regulator UGYR_06385 ENOG4105DAA L-lactate UGYR_06390 ENOG4105DMF Dehydrogenase UGYR_06395 ENOG4105DWT malate dehydrogenase (quinone) UGYR_06400 ENOG4105VEQ Cold shock protein UGYR_06410 ENOG4108SAJ Protein of unknown function (DUF1198) UGYR_06415 ENOG4108WMJ Protein of unknown function (DUF2002) UGYR_06430 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) UGYR_06435 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) UGYR_06445 ENOG4108IJ7 Glycine betaine UGYR_06450 ENOG4108HQS Glycine betaine UGYR_06455 ENOG4105GIJ Glycine betaine UGYR_06465 ENOG4105EQ0 Major Facilitator superfamily UGYR_06470 ENOG4105NTK Transcriptional repressor Mpra UGYR_06480 ENOG4105CW7 secretion protein, HlyD family UGYR_06485 ENOG4105C0R drug resistance transporter emrb qaca subfamily UGYR_06490 ENOG4105EIB trna rrna methyltransferase UGYR_06495 ENOG4105K63 Thioredoxin UGYR_06500 ENOG4106IUH DTW domain containing protein UGYR_06505 ENOG4105CD5 CoA-binding domain protein UGYR_06510 ENOG4105JIM Phosphatidylserine synthase UGYR_06515 ENOG4105T42 (LipO)protein UGYR_06540 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase UGYR_06550 ENOG4108UMI ABC transporter, permease UGYR_06555 ENOG4105D01 (LipO)protein UGYR_06560 ENOG4108R8X outer membrane lipoprotein UGYR_06565 ENOG4108R96 Methyltransferase, YaeB family UGYR_06570 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) UGYR_06575 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion UGYR_06580 ENOG4108YZN class I peptide chain release factor UGYR_06585 ENOG4108VWS Yaeq family UGYR_06595 ENOG4105M1T rho-binding antiterminator UGYR_06600 ENOG4105N7H Cytochrome UGYR_06605 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) UGYR_06610 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase UGYR_06625 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) UGYR_06630 ENOG4105C0B DNA polymerase III (alpha subunit) UGYR_06635 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) UGYR_06640 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) UGYR_06645 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) UGYR_06655 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) UGYR_06660 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) UGYR_06670 ENOG4105DZP Membrane-associated zinc metalloprotease UGYR_06675 ENOG4105KNE Phosphatidate cytidylyltransferase UGYR_06680 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) UGYR_06695 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) UGYR_06700 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) UGYR_06710 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) UGYR_06715 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) UGYR_06720 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) UGYR_06725 ENOG4108T8E UPF0325 protein UGYR_06730 ENOG4105QDK Flavodoxin UGYR_06735 ENOG4105DR9 pseudouridine synthase UGYR_06740 ENOG4105WP7 tRNA pseudouridine synthase C UGYR_06745 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) UGYR_06755 ENOG4105EWT decarboxylase family UGYR_06765 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) UGYR_06770 ENOG4105M08 Membrane UGYR_06775 ENOG4105ETT transcriptional Regulator, LysR family UGYR_06780 ENOG4105M5B (LipO)protein UGYR_06785 ENOG4105C9B Cysteine desulfurase UGYR_06790 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) UGYR_06795 ENOG4105CUZ uba thif-type nad fad binding protein UGYR_06800 ENOG4105CA3 membrane-bound lytic murein transglycosylase UGYR_06820 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase UGYR_06825 ENOG4107QZM n-acetylglutamate synthase UGYR_06830 ENOG4107QYX exodeoxyribonuclease v alpha UGYR_06835 ENOG4107QKA exodeoxyribonuclease V beta UGYR_06840 ENOG4107QXK peptidase UGYR_06845 ENOG4105DSY exodeoxyribonuclease V, gamma UGYR_06850 ENOG4105RVB Prepilin peptidase dependent protein c UGYR_06880 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) UGYR_06885 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase UGYR_06895 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) UGYR_06900 ENOG4105EE5 Membrane protein terC UGYR_06905 ENOG4105CPC Aldo Keto reductase UGYR_06910 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) UGYR_06915 ENOG4105CEY Amp-dependent synthetase and ligase UGYR_06920 ENOG41060NJ transcriptional regulator UGYR_06925 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) UGYR_06930 ENOG4105RQF LysR family Transcriptional regulator UGYR_06935 ENOG4105EJC lysr family transcriptional regulator UGYR_06975 ENOG4108WWZ General secretion pathway protein J UGYR_06990 ENOG4108VAU general secretion pathway protein G UGYR_06995 ENOG4105D7Q type ii secretion system UGYR_07000 ENOG4107QHF type ii secretion system protein e UGYR_07030 ENOG4105DHJ ABC, transporter UGYR_07045 ENOG4105CRK lysyL-tRNA synthetase UGYR_07050 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) UGYR_07055 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) UGYR_07060 ENOG4105T95 Thiol disulfide interChange protein UGYR_07065 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) UGYR_07070 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) UGYR_07080 ENOG4105Y75 tpr repeat protein UGYR_07090 ENOG4108UT2 hemolysin iii UGYR_07105 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) UGYR_07110 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family UGYR_07115 ENOG4105D0A hydroxylase UGYR_07120 ENOG4107RAQ aminopeptidase UGYR_07130 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) UGYR_07135 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase UGYR_07140 ENOG4108JQ1 Dehydrogenase UGYR_07145 ENOG4105E66 phosphoriboisomerase A UGYR_07155 ENOG4105MPN Membrane UGYR_07160 ENOG4108ZUB Lysine exporter protein (Lyse ygga) UGYR_07165 ENOG4105D64 Mechanosensitive ion channel UGYR_07170 ENOG4105D2N Aldolase UGYR_07175 ENOG4105BZA Phosphoglycerate kinase UGYR_07180 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase UGYR_07185 ENOG4105CV1 Transketolase (EC 2.2.1.1) UGYR_07195 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) UGYR_07200 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP UGYR_07215 ENOG41080HT Transcriptional regulator, arsr family UGYR_07220 ENOG4105GPY SprT protein UGYR_07225 ENOG4105RWS endonuclease I UGYR_07230 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) UGYR_07235 ENOG4105D7Z glutathione synthase UGYR_07240 ENOG4108UJU UPF0301 protein UGYR_07245 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) UGYR_07250 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) UGYR_07260 ENOG4105CZX twitching motility protein UGYR_07265 ENOG4105DFA alanine racemase domain protein UGYR_07270 ENOG4105II7 pyrroline-5-carboxylate reductase UGYR_07275 ENOG4108VIA integral membrane protein UGYR_07280 ENOG4105VZ9 UPF0235 protein UGYR_07285 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) UGYR_07290 ENOG4105CSA Coproporphyrinogen iii oxidase UGYR_07295 ENOG4105K33 Periplasmic Protein UGYR_07300 ENOG4105CSV Glutaminase UGYR_07305 ENOG41090ED Protein with unknown function (DUF469) UGYR_07315 ENOG4105CEN a g-specific adenine glycosylase UGYR_07320 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) UGYR_07325 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division UGYR_07340 ENOG410658X UGYR_07350 ENOG410787A Pts system, glucitol sorbitol-specific UGYR_07355 ENOG4105DZY Pts system, glucitol sorbitol-specific UGYR_07360 ENOG4105VI0 Pts system, glucitol sorbitol-specific UGYR_07365 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase UGYR_07370 ENOG4105J92 DNA-binding transcriptional activator GutM UGYR_07375 ENOG410804X Transcriptional regulator UGYR_07385 ENOG4105DE4 1-phosphofructokinase UGYR_07390 ENOG4105C6N Formate acetyltransferase UGYR_07395 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) UGYR_07400 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) UGYR_07405 ENOG4105C7B Threonine dehydratase UGYR_07415 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase UGYR_07420 ENOG4105WQI isochorismatase UGYR_07425 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase UGYR_07430 ENOG4105E4F Isochorismate synthase UGYR_07435 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein UGYR_07445 ENOG4105DQ5 transport system permease protein UGYR_07450 ENOG4105TVJ transport system, permease UGYR_07455 ENOG4105E0A ABC, transporter UGYR_07465 ENOG4105CEY Amp-dependent synthetase and ligase UGYR_07470 ENOG4105WQT MbtH domain protein UGYR_07480 ENOG4105E0K tonB-dependent siderophore receptor UGYR_07485 ENOG4105F9E Shikimate 5-dehydrogenase UGYR_07560 ENOG4108ZZF transport protein (ExbD) UGYR_07565 ENOG4105CWK Biopolymer transport protein, ExbB UGYR_07570 ENOG4105C28 cystathionine UGYR_07575 ENOG4108K81 inner membrane protein YghB UGYR_07580 ENOG4105CF7 AraC family transcriptional regulator UGYR_07585 ENOG4108I6A alcohol dehydrogenase UGYR_07590 ENOG4105CV8 reductase UGYR_07600 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) UGYR_07605 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase UGYR_07610 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) UGYR_07615 ENOG4105NF4 modulator of drug activity UGYR_07620 ENOG410642W LysR family Transcriptional regulator UGYR_07625 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) UGYR_07630 ENOG4105IPS esterase UGYR_07640 ENOG4108SX3 cytoplasmic protein UGYR_07645 ENOG41087AY ADP-Ribose pyrophosphatase UGYR_07650 ENOG4105DFG type I secretion outer membrane protein UGYR_07655 ENOG4105F1G UPF0441 protein UGYR_07660 ENOG4106032 Glutathionylspermidine synthase UGYR_07665 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b UGYR_07670 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) UGYR_07675 ENOG4105W0Z cytoplasmic protein UGYR_07680 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) UGYR_07690 ENOG4105I7R Adenylate cyclase UGYR_07695 ENOG4106MWK domain protein UGYR_07700 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate UGYR_07705 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) UGYR_07710 ENOG4107ZVW dihydroneopterin aldolase UGYR_07715 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) UGYR_07720 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) UGYR_07725 ENOG4105VCC 30S ribosomal protein S21 UGYR_07730 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) UGYR_07735 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) UGYR_07755 ENOG4105DTD Dehydrogenase UGYR_07770 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase UGYR_07785 ENOG4105CKT filamentous hemagglutinin UGYR_07825 ENOG4105CKT filamentous hemagglutinin UGYR_07830 ENOG4105D5K Hemolysin activator protein UGYR_07835 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase UGYR_07850 ENOG4108VKG metal-dependent hydrolase UGYR_07855 ENOG4105EE0 oxidoreductase UGYR_07860 ENOG4105DU1 integral membrane protein, terc UGYR_07865 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) UGYR_07875 ENOG4105CTX dehydratase UGYR_07880 ENOG4107QZW Altronate oxidoreductase UGYR_07890 ENOG4105DPW Major facilitator superfamily MFS_1 UGYR_07905 ENOG4106W5V Membrane UGYR_07920 ENOG4105NE1 Conserved Protein UGYR_07925 ENOG41090KG Inner membrane protein YqjE UGYR_07930 ENOG4105YJD UGYR_07935 ENOG4108VBZ doxx family UGYR_07940 ENOG4105CWB LysR family transcriptional Regulator UGYR_07945 ENOG4108CNN domain protein UGYR_07950 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) UGYR_07965 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) UGYR_07970 ENOG4105W4M Transport-associated protein UGYR_07975 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase UGYR_07980 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain UGYR_07985 ENOG4105BZU Histidine kinase UGYR_07990 ENOG4105N5T Radical SAM Protein UGYR_07995 ENOG4105CBC glutamate synthase UGYR_08000 ENOG4105BZ8 glutamate synthase UGYR_08010 ENOG4105KB2 stringent starvation protein b UGYR_08015 ENOG4107MKT Stringent starvation protein a UGYR_08020 ENOG4108UJD 30S ribosomal protein S9 UGYR_08025 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) UGYR_08030 ENOG4105D6Z AFG1 family ATPase UGYR_08035 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III UGYR_08040 ENOG4105C0H protease UGYR_08050 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) UGYR_08055 ENOG4105VFK BolA family UGYR_08060 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane UGYR_08065 ENOG4105E3I toluene tolerance UGYR_08070 ENOG4107PE3 Mammalian cell entry related domain protein UGYR_08075 ENOG4105CY3 ABC transporter, permease UGYR_08080 ENOG4105DHJ ABC, transporter UGYR_08085 ENOG4105FEU K -dependent Na -Ca exchanger UGYR_08090 ENOG4105C2X Arabinose 5-phosphate isomerase UGYR_08095 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase UGYR_08100 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) UGYR_08105 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA UGYR_08110 ENOG4108IUZ ABC transporter UGYR_08115 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) UGYR_08120 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA UGYR_08125 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN UGYR_08135 ENOG41080Z8 PHOSPHOCARRIER protein UGYR_08140 ENOG4105CXT aspartate transcarbamylase UGYR_08145 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) UGYR_08150 ENOG4105KME endoribonuclease L-psp UGYR_08155 ENOG4105CG3 alpha amylase, catalytic region UGYR_08160 ENOG4105C5Y PTS System UGYR_08165 ENOG4105D4X repressor UGYR_08170 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic UGYR_08185 ENOG4105NXH GreA GreB family elongation factor UGYR_08190 ENOG4108XVM Cytochrome b(562) UGYR_08195 ENOG4105CMS peptidase U62, modulator of DNA gyrase UGYR_08200 ENOG4105N42 UPF0307 protein UGYR_08205 ENOG4105UNR (Barnase) inhibitor UGYR_08210 ENOG4105GGE ribonuclease UGYR_08220 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) UGYR_08225 ENOG4105Y49 secretion protein, HlyD family UGYR_08235 ENOG4105CR8 Transcriptional regulator UGYR_08240 ENOG4105D1U peptidase U62 modulator of DNA gyrase UGYR_08250 ENOG4105QD6 exported protein UGYR_08255 ENOG4105C03 ribonuclease UGYR_08265 ENOG4105VQ7 Rod shape-determining protein MreD UGYR_08270 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) UGYR_08275 ENOG4105DFF Rod shape-determining protein mreb UGYR_08280 ENOG41062P1 Diguanylate cyclase phosphodiesterase UGYR_08285 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family UGYR_08290 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) UGYR_08295 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) UGYR_08305 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein UGYR_08310 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase UGYR_08315 ENOG4105RG0 Membrane UGYR_08320 ENOG4108IA2 Sodium pantothenate symporter UGYR_08325 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) UGYR_08330 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) UGYR_08335 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) UGYR_08345 ENOG4105D1S lipid A biosynthesis UGYR_08350 ENOG4107B2H carbonic anhydrase UGYR_08355 ENOG41067MG lrgb family UGYR_08365 ENOG4105CMU LysR family (Transcriptional regulator UGYR_08370 ENOG4105EEQ Na H antiporter UGYR_08375 ENOG4105C7N Xanthine uracil vitamin C permease UGYR_08385 ENOG4108UUM single-stranded DNA-binding protein UGYR_08390 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) UGYR_08395 ENOG4105MSB protein, conserved in bacteria UGYR_08400 ENOG4105CGF Aromatic amino acid aminotransferase UGYR_08405 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) UGYR_08410 ENOG4105CDU Replicative dna helicase UGYR_08415 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein UGYR_08420 ENOG4105P4Z Phage shock protein G UGYR_08425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) UGYR_08430 ENOG4105MYN Zinc uptake regulation protein UGYR_08435 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) UGYR_08440 ENOG41080IJ Diacylglycerol kinase UGYR_08445 ENOG4105E55 glycerol-3-phosphate acyltransferase UGYR_08460 ENOG4107W52 maltose operon periplasmic protein UGYR_08465 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) UGYR_08480 ENOG4107FKK extracellular solute-binding protein family 1 UGYR_08485 ENOG4105D56 permease protein UGYR_08490 ENOG4105EG2 ABC transporter, permease UGYR_08495 ENOG4108VY7 phosphate-starvation-inducible protein PsiE UGYR_08505 ENOG4105CFH Aspartokinase UGYR_08620 ENOG4108KB2 LysR family Transcriptional regulator UGYR_08635 ENOG4105C3R Methionine synthase UGYR_08640 ENOG41069M3 Transcriptional regulator UGYR_08650 ENOG4108I9X Isocitrate lyase UGYR_08655 ENOG4107QP3 malate synthase g UGYR_08695 ENOG4105DC1 bifunctional purine biosynthesis protein purh UGYR_08700 ENOG4105C12 Phosphoribosylglycinamide synthetase UGYR_08705 ENOG4108T8B Protein of unknown function (DUF1481) UGYR_08710 ENOG4105K70 DNA-binding protein UGYR_08715 ENOG4105R2J Conserved Protein UGYR_08720 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) UGYR_08725 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) UGYR_08730 ENOG4105E09 nadh pyrophosphatase UGYR_08735 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor UGYR_08740 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) UGYR_08750 ENOG4105D06 uba thif-type nad fad binding protein UGYR_08755 ENOG4105WHD thiamine biosynthesis protein ThiS UGYR_08760 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) UGYR_08765 ENOG4105D41 biosynthesis protein thiH UGYR_08770 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) UGYR_08775 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) UGYR_08780 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) UGYR_08785 ENOG4108VZM 50s ribosomal protein L10 UGYR_08795 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) UGYR_08800 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) UGYR_08805 ENOG4105PM1 preprotein translocase subunit SecE UGYR_08840 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase UGYR_08845 ENOG4105D4A Cell wall formation (By similarity) UGYR_08875 ENOG4108RR8 protoporphyrinogen oxidase UGYR_08880 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) UGYR_08885 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein UGYR_08895 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase UGYR_08905 ENOG4107QK7 reductase UGYR_08920 ENOG4105MDZ Transcriptional activator rfaH UGYR_08925 ENOG4105D52 delta-aminolevulinic acid dehydratase UGYR_08935 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) UGYR_08945 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) UGYR_08950 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) UGYR_08955 ENOG4105JC1 sterol-binding domain protein UGYR_08960 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) UGYR_08965 ENOG4105CGY Dna recombination protein UGYR_08970 ENOG4108KF1 Membrane UGYR_08985 ENOG4107SXA Phosphorylase UGYR_08990 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) UGYR_08995 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) UGYR_09000 ENOG4105DZ2 Transcriptional regulator UGYR_09005 ENOG4105EMK carboxylate amino acid amine transporter UGYR_09015 ENOG4107T6V glycerophosphoryl diester phosphodiesterase UGYR_09025 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component UGYR_09030 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component UGYR_09035 ENOG4105BZ7 extracellular solute-binding protein family 1 UGYR_09070 ENOG4108IV0 ABC, transporter UGYR_09075 ENOG4105C0Z ABC transporter UGYR_09080 ENOG4105CF8 branched-chain amino acid ABC transporter, permease UGYR_09085 ENOG4105C32 Amino acid ABC transporter (Permease) UGYR_09095 ENOG4105U59 -acetyltransferase UGYR_09100 ENOG4105BZW Glycerate kinase UGYR_09105 ENOG4107QQ0 gntp family UGYR_09110 ENOG4107VHA regulatoR UGYR_09120 ENOG4105CRP Part of the ABC transporter FtsEX involved in UGYR_09125 ENOG4105CAK Cell division ATP-binding protein ftsE UGYR_09130 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) UGYR_09130 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) UGYR_09135 ENOG4106H78 methyltransferase UGYR_09140 ENOG4105MG3 Membrane UGYR_09155 ENOG4107FS9 Membrane UGYR_09170 ENOG4105EX9 Membrane UGYR_09175 ENOG4108W1V Lipoprotein UGYR_09180 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) UGYR_09190 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A UGYR_09200 ENOG4105CXY transporter UGYR_09205 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase UGYR_09210 ENOG4105DQF Hydrolase UGYR_09215 ENOG4108EUD Lysophospholipase UGYR_09220 ENOG4105CCF Lysine exporter protein (Lyse ygga) UGYR_09225 ENOG4105C9U ATP-dependent DNA helicase RecQ UGYR_09230 ENOG4105HDD phospholipase UGYR_09235 ENOG4108VUY thioesterase Superfamily protein UGYR_09240 ENOG4105FR1 rard protein UGYR_09245 ENOG4107QUT magnesium and cobalt transport protein CorA UGYR_09260 ENOG4105EQN UPF0261 protein UGYR_09270 ENOG4105C4R Atp-dependent dna helicase UGYR_09275 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant UGYR_09280 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) UGYR_09285 ENOG4105CT0 Protein of unknown function, DUF484 UGYR_09290 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) UGYR_09295 ENOG4105S7Z (LipO)protein UGYR_09310 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) UGYR_09315 ENOG41076E6 Uroporphyrinogen-III Synthase UGYR_09320 ENOG4105ECF c-methyltransferase UGYR_09325 ENOG410601J HemY protein UGYR_09355 ENOG4105C85 amino acid UGYR_09375 ENOG4105EGZ biosynthesis protein UGYR_09380 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase UGYR_09385 ENOG4108WJ1 acetyltransferase UGYR_09390 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) UGYR_09395 ENOG4105C1B dTDP-glucose 4-6-dehydratase UGYR_09400 ENOG4108IJ1 Dehydrogenase UGYR_09405 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase UGYR_09410 ENOG4105SFE lipopolysaccharide biosynthesis protein UGYR_09415 ENOG4105ESV Glycosyl transferase, family 4 UGYR_09425 ENOG4105K63 Thioredoxin UGYR_09435 ENOG4105C9X ppx gppa phosphatase UGYR_09440 ENOG4105C4R Atp-dependent dna helicase UGYR_09445 ENOG4105KQ5 peptidylprolyl cis-trans isomerase UGYR_09455 ENOG4105EMY transcriptional regulator UGYR_09460 ENOG4108M1A Chitin-binding protein UGYR_09465 ENOG4105C7B Threonine dehydratase UGYR_09470 ENOG4105C01 Dihydroxy-acid dehydratase UGYR_09475 ENOG4105CM2 brancheD-chain amino acid aminotransferase UGYR_09480 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit UGYR_09490 ENOG4105C0P Mg chelatase subunit ChlI UGYR_09495 ENOG4108WFC UPF0438 protein yifE UGYR_09500 ENOG4105CVI Transcriptional regulator UGYR_09555 ENOG4108Y73 Membrane UGYR_09565 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) UGYR_09575 ENOG4105EHV domain protein UGYR_09580 ENOG4107QN2 dihydrolipoyl dehydrogenase UGYR_09600 ENOG4107QZV Type I secretion membrane fusion protein UGYR_09615 ENOG4105X58 receptor UGYR_09620 ENOG4105CH7 arginosuccinase UGYR_09625 ENOG4105CDH Citrulline--aspartate ligase UGYR_09630 ENOG4105CAS nag kinase UGYR_09635 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase UGYR_09655 ENOG4105SYT Methylenetetrahydrofolate reductase UGYR_09670 ENOG4105CFH Aspartokinase UGYR_09675 ENOG4105C28 cystathionine UGYR_09680 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) UGYR_09690 ENOG4105C25 Primosomal protein n' UGYR_09695 ENOG4105ETE Transcriptional regulator (LacI family UGYR_09700 ENOG41063M6 Cell Division Protein UGYR_09705 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) UGYR_09710 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) UGYR_09715 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase UGYR_09720 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) UGYR_09725 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) UGYR_09730 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) UGYR_09735 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) UGYR_09740 ENOG4105CBT Fructose-1,6-bisphosphatase UGYR_09745 ENOG4105E5M Multidrug resistance protein D UGYR_09750 ENOG4105DP0 ferredoxin-NADP reductase UGYR_09755 ENOG4108VTS Membrane UGYR_09760 ENOG4105EBK exported protein UGYR_09770 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein UGYR_09780 ENOG41076HS cation diffusion facilitator family transporter UGYR_09785 ENOG4105FMW periplasmic UGYR_09790 ENOG4105E3W Two component transcriptional regulator (Winged helix family UGYR_09795 ENOG4105E0F Histidine kinase UGYR_09800 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) UGYR_09805 ENOG4105D7W serine acetyltransferase UGYR_09810 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase UGYR_09815 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) UGYR_09820 ENOG4105VW4 glutaredoxin 3 UGYR_09825 ENOG4107YZP Rhodanese domain protein UGYR_09830 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) UGYR_09835 ENOG41063SB peptidase UGYR_09840 ENOG4105PXI polysaccharide deacetylase UGYR_09850 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) UGYR_09855 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) UGYR_09860 ENOG4105XA0 heptosyltransferase ii UGYR_09865 ENOG4105D16 lipopolysaccharide heptosyltransferase i UGYR_09870 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase UGYR_09890 ENOG4105W0E 50S ribosomal protein L33 UGYR_09895 ENOG4105KDC 50s ribosomal protein l28 UGYR_09900 ENOG4105W5Q DNA repair protein (RadC UGYR_09905 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase UGYR_09910 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) UGYR_09915 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) UGYR_09920 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) UGYR_09925 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) UGYR_09930 ENOG4105DSJ YicC domain protein UGYR_09940 ENOG4105DUM transcriptional regulator, lysR family UGYR_09945 ENOG4105BZU Histidine kinase UGYR_09965 ENOG4105E39 Enoyl-CoA hydratase UGYR_09970 ENOG4105D9N nucleoside UGYR_09980 ENOG4105EN6 Membrane UGYR_09985 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) UGYR_09995 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) UGYR_10000 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) UGYR_10005 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase UGYR_10010 ENOG4105CB5 ATP-dependent DNA helicase recG UGYR_10015 ENOG4105D6U Sodium Glutamate Symporter UGYR_10020 ENOG4105C2W permease UGYR_10025 ENOG4105JV1 AsmA family UGYR_10030 ENOG4105SUU thioesterase domain UGYR_10045 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 UGYR_10055 ENOG4105C5F glutamine synthetase UGYR_10060 ENOG4105CUX Signal transduction histidine kinase UGYR_10065 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family UGYR_10070 ENOG4105D4P Coproporphyrinogen iii oxidase UGYR_10080 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) UGYR_10085 ENOG4105C2M dna polymerase I UGYR_10090 ENOG4108Z33 Thiol disulfide Interchange Protein UGYR_10095 ENOG4105E27 serine threonine protein kinase UGYR_10100 ENOG4105PC1 Conserved Protein UGYR_10110 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b UGYR_10135 ENOG4107EJG GntR family transcriptional regulator UGYR_10140 ENOG4105ETE Transcriptional regulator (LacI family UGYR_10145 ENOG4108RVA ribokinase UGYR_10150 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator UGYR_10155 ENOG4105CNN ABC, transporter UGYR_10160 ENOG4105C2J ABC transporter UGYR_10165 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) UGYR_10175 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) UGYR_10180 ENOG4105EV2 VWA domain protein interacting with AAA ATPase UGYR_10190 ENOG4105CU9 asparagine synthetase A UGYR_10195 ENOG4108VVK transcriptional Regulator, AsnC UGYR_10200 ENOG4105QTB Flavodoxin UGYR_10205 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) UGYR_10210 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) UGYR_10215 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation UGYR_10220 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) UGYR_10225 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) UGYR_10230 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) UGYR_10240 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) UGYR_10245 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) UGYR_10255 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) UGYR_10265 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) UGYR_10270 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) UGYR_10275 ENOG4105C8U phosphate abc transporter UGYR_10280 ENOG4105E2Z phosphate ABC transporter (Permease UGYR_10295 ENOG4106PMH Extracellular solute-binding protein family 3 UGYR_10300 ENOG4105EAD ABC transporter UGYR_10305 ENOG4105DRP amino acid AbC transporter UGYR_10310 ENOG4105C7N Xanthine uracil vitamin C permease UGYR_10315 ENOG4105C8Q Methyl-accepting chemotaxis UGYR_10325 ENOG4108VCD Chaperone UGYR_10330 ENOG4105CW0 outer membrane usher protein UGYR_10340 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) UGYR_10345 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins UGYR_10355 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) UGYR_10360 ENOG4105VG0 50S ribosomal protein l34 UGYR_10370 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) UGYR_10380 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) UGYR_10385 ENOG410667J hydrolase UGYR_10390 ENOG4105D99 atp gtp-binding protein UGYR_10395 ENOG4105R2A (LipO)protein UGYR_10410 ENOG4105D0C transport protein UGYR_10415 ENOG4105JKW Valine--pyruvate aminotransferase UGYR_10420 ENOG4108ZG0 Ompa motb domain protein UGYR_10440 ENOG4108R3E Dna-3-methyladenine glycosylase i UGYR_10460 ENOG4106JH6 (LipO)protein UGYR_10490 ENOG4105CTS PTS system mannitol-specific UGYR_10500 ENOG4105E61 Mannitol repressor protein UGYR_10505 ENOG4108YYI Protein of unknown function (DUF2810) UGYR_10510 ENOG4108RPX mosc domain containing protein UGYR_10515 ENOG4105C8Q Methyl-accepting chemotaxis UGYR_10520 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) UGYR_10530 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) UGYR_10535 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) UGYR_10540 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein UGYR_10545 ENOG4108MG3 formate dehydrogenase UGYR_10555 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) UGYR_10560 ENOG4105EM7 Selenocysteine-specific translation elongation factor UGYR_10565 ENOG4108UQS dipeptidase UGYR_10575 ENOG4105MEV Acyl-transferase UGYR_10605 ENOG4105CGP Urocanate hydratase UGYR_10610 ENOG4105C84 Histidine ammonia-lyase UGYR_10615 ENOG4105C85 amino acid UGYR_10630 ENOG4105DIJ Phosphoethanolamine transferase UGYR_10635 ENOG4108KX4 response regulator UGYR_10640 ENOG4105BZU Histidine kinase UGYR_10645 ENOG4105CXY transporter UGYR_10655 ENOG4105DEF Extracellular solute-binding protein, family 5 UGYR_10660 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component UGYR_10665 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UGYR_10670 ENOG4105C3U ABC transporter UGYR_10675 ENOG4108JQ7 (ABC) transporter UGYR_10680 ENOG4105D1V cellulose synthase operon protein YhjU UGYR_10685 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT UGYR_10700 ENOG4105UTS cellulose synthase operon protein YhjQ UGYR_10705 ENOG4107QZ7 Cellulose synthase catalytic subunit UGYR_10710 ENOG4107EEX Cellulose synthase regulator protein UGYR_10715 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) UGYR_10720 ENOG4105EJG cellulose synthase UGYR_10725 ENOG4105BZU Histidine kinase UGYR_10730 ENOG4105CK2 sodium dicarboxylate symporter UGYR_10735 ENOG4105CS0 peptidase UGYR_10740 ENOG4107SS6 2-dehydro-3-deoxygluconokinase UGYR_10745 ENOG4105VSH 4-oxalocrotonate tautomerase UGYR_10750 ENOG4105CMB EAL domain-containing protein UGYR_10755 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) UGYR_10760 ENOG4107H3J ribonuclease UGYR_10765 ENOG4105EXG Transcriptional regulator UGYR_10770 ENOG4105CK2 sodium dicarboxylate symporter UGYR_10775 ENOG4105C28 cystathionine UGYR_10780 ENOG4105DC8 reductase UGYR_10785 ENOG4105D6S protein involved in catabolism of external DNA UGYR_10790 ENOG4105DGW oligopeptidase A UGYR_10795 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) UGYR_10805 ENOG4108M6U Universal stress protein A UGYR_10815 ENOG4105CJ3 phosphate transporter UGYR_10820 ENOG4105CBX hi0933 family UGYR_10830 ENOG4105WCN acetyltransferase UGYR_10835 ENOG4105C2I pirin domain protein UGYR_10840 ENOG4105DIQ Transcriptional regulator UGYR_10845 ENOG4105C6Z Gluconate UGYR_10850 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family UGYR_10855 ENOG41076UM multiple antibiotic resistance (MarC)-related protein UGYR_10860 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) UGYR_10865 ENOG4108HRK Histidine kinase UGYR_10870 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) UGYR_10875 ENOG4108IUM Glycogen debranching enzyme UGYR_10880 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) UGYR_10885 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) UGYR_10890 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) UGYR_10895 ENOG4105C6V Glycerol-3-phosphate dehydrogenase UGYR_10900 ENOG4105E98 transcriptional regulator DeoR family UGYR_10905 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) UGYR_10915 ENOG41061ZR Transcriptional regulator UGYR_10920 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) UGYR_10925 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) UGYR_10935 ENOG4105MJ2 Competence protein UGYR_10940 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) UGYR_10950 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) UGYR_10955 ENOG4105CE1 Ferrous iron transport protein b UGYR_10960 ENOG4105XFK Ferrous iron transport protein A UGYR_10965 ENOG4105BZM domain protein UGYR_10990 ENOG4108RRZ Transcription elongation factor GreB UGYR_10995 ENOG4105DPZ Two component transcriptional regulator (Winged helix family UGYR_11000 ENOG4105E0F Histidine kinase UGYR_11005 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase UGYR_11015 ENOG4105VEJ Heat shock protein UGYR_11020 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 UGYR_11025 ENOG4105DQY intracellular growth attenuator UGYR_11030 ENOG4107RK2 ADP-ribose diphosphatase NudE UGYR_11035 ENOG4108JQC penicillin-binding protein 1A UGYR_11060 ENOG4105E4G Type IV pilus UGYR_11065 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) UGYR_11085 ENOG4105DJV ribulose-phosphate 3-epimerase UGYR_11095 ENOG4105C31 Tryptophanyl-tRNA synthetase UGYR_11105 ENOG4107V9H nitrite transporter UGYR_11110 ENOG4105WZK nitrite reductase NADPH small subunit UGYR_11115 ENOG4107QZF nitrite reductase NADPH large subunit UGYR_11120 ENOG4105DZC cytosine deaminase UGYR_11125 ENOG4106DTQ Protein TsgA homolog UGYR_11140 ENOG41060NJ transcriptional regulator UGYR_11145 ENOG4105F8D glycoside hydrolase family 4 UGYR_11155 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) UGYR_11165 ENOG4105C8Y Acetylornithine aminotransferase UGYR_11170 ENOG410613R integral membrane protein, YccS YhfK family UGYR_11175 ENOG4107RYR Transcriptional regulator, Crp Fnr family UGYR_11180 ENOG4108UKZ OsmC family UGYR_11205 ENOG4105C6T cysteine synthase UGYR_11210 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) UGYR_11220 ENOG4105DNZ Alpha Beta Hydrolase UGYR_11230 ENOG4105DKP glycosyl transferase, family 9 UGYR_11235 ENOG4105K64 Glycosyl transferase, family 2 UGYR_11240 ENOG4105C5H ABC transporter UGYR_11245 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein UGYR_11255 ENOG4105VKU nucleicacid-binding protein UGYR_11260 ENOG4108YZY peptidylprolyl cis-trans isomerase UGYR_11270 ENOG4108V1T peptidylprolyl cis-trans isomerase UGYR_11275 ENOG4105WWK YheO domain protein UGYR_11285 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) UGYR_11290 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) UGYR_11300 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) UGYR_11310 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) UGYR_11325 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) UGYR_11335 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) UGYR_11340 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity UGYR_11345 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) UGYR_11350 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) UGYR_11355 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) UGYR_11360 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) UGYR_11365 ENOG41083MP 50s ribosomal protein l29 UGYR_11370 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal UGYR_11375 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) UGYR_11385 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits UGYR_11395 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) UGYR_11410 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) UGYR_11415 ENOG4105VPB 50S ribosomal protein L30 UGYR_11420 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) UGYR_11425 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) UGYR_11430 ENOG41067V7 50S ribosomal protein L36 UGYR_11435 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits UGYR_11445 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) UGYR_11450 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) UGYR_11455 ENOG4108ZT0 50S ribosomal protein l17 UGYR_11460 ENOG4105W1Y Transcriptional regulator UGYR_11465 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system UGYR_11470 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) UGYR_11475 ENOG4105C1A potassium transporter peripheral membrane UGYR_11480 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B UGYR_11485 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) UGYR_11490 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) UGYR_11495 ENOG4105C79 DNA protecting protein DprA UGYR_11500 ENOG4108RPN Protein smg homolog UGYR_11505 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) UGYR_11515 ENOG4108Z0R Transferase UGYR_11545 ENOG4107QN1 sodium solute UGYR_11550 ENOG41062QD Membrane UGYR_11555 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) UGYR_11560 ENOG4105CK2 sodium dicarboxylate symporter UGYR_11570 ENOG4108SIC Transcriptional regulator UGYR_11575 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) UGYR_11585 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter UGYR_11610 ENOG4108ZVF (LipO)protein UGYR_11615 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein UGYR_11625 ENOG4108M1A Chitin-binding protein UGYR_11640 ENOG4106P2F Pfam:Pili_assembly_C UGYR_11645 ENOG4106PG1 outer membrane usher protein UGYR_11655 ENOG4105KPY Small multidrug resistance protein UGYR_11665 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) UGYR_11670 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) UGYR_11685 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) UGYR_11690 ENOG4105EGS Mechanosensitive ion channel UGYR_11695 ENOG4105DJ4 phosphatidylserine decarboxylase UGYR_11700 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) UGYR_11705 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) UGYR_11725 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) UGYR_11730 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) UGYR_11735 ENOG4105K8N protein family UPF0079, ATPase UGYR_11740 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase UGYR_11750 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) UGYR_11760 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) UGYR_11765 ENOG4107QJR hflk protein UGYR_11770 ENOG4105EPW hflc protein UGYR_11780 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis UGYR_11785 ENOG4105KPV Transcriptional regulator UGYR_11790 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) UGYR_11795 ENOG4105C2N RNA methyltransferase TrmH family group 3 UGYR_11815 ENOG4108S1B Periplasmic chaperone protein UGYR_11820 ENOG4105E6S usher protein( UGYR_11840 ENOG4108MXZ Esterase UGYR_11850 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) UGYR_11855 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) UGYR_11860 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) UGYR_11865 ENOG4105K9Q Binds to the 23S rRNA (By similarity) UGYR_11870 ENOG4105FHY Opacity-associated protein A UGYR_11875 ENOG4108V1T peptidylprolyl cis-trans isomerase UGYR_11885 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic UGYR_11890 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase UGYR_11895 ENOG4108UUE Transcriptional regulator UGYR_11900 ENOG41061GZ Protein of unknown function (DUF1107) UGYR_11905 ENOG4105C37 (CBS) domain UGYR_11910 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) UGYR_11915 ENOG4105CFU surface antigen UGYR_11920 ENOG4105MA0 exported protein UGYR_11925 ENOG4108ZHD aig2 family UGYR_11930 ENOG4105F0N pyrophosphate phospho-hydrolase UGYR_11940 ENOG4105DFU Cell wall formation (By similarity) UGYR_11955 ENOG4105HVQ Regulatory factor of maltose metabolism UGYR_11970 ENOG4105EAH synthase UGYR_11985 ENOG4105QYV Membrane UGYR_11990 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control UGYR_12005 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase UGYR_12010 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) UGYR_12015 ENOG4105HBR Rna-binding protein UGYR_12020 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) UGYR_12025 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) UGYR_12030 ENOG4105EEI dihydropteroate synthase UGYR_12035 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) UGYR_12060 ENOG4105CHV Transcription elongation factor NusA UGYR_12070 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) UGYR_12085 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) UGYR_12095 ENOG4105C1J atp-dependent rna helicase UGYR_12100 ENOG4105DEN Luciferase family UGYR_12105 ENOG4105C44 Serine transporter UGYR_12115 ENOG4106RZ4 Peptidase U32 UGYR_12120 ENOG4105CFP Peptidase U32 UGYR_12125 ENOG4105XPQ lipid carrier protein UGYR_12130 ENOG4108YYD acetyltransferase UGYR_12135 ENOG41082IR Excinuclease ABC C subunit domain protein UGYR_12140 ENOG4105D5Q Arginine ornithine antiporter UGYR_12145 ENOG4105CXN decarboxylase UGYR_12155 ENOG4108ZPB UPF0306 protein UGYR_12160 ENOG4105K4T epimerase UGYR_12165 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein UGYR_12170 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) UGYR_12175 ENOG4105FD8 phosphonate metabolism protein PhnM UGYR_12180 ENOG4105HRV phosphonate c-p lyase system protein phnl UGYR_12185 ENOG4105ENV phosphonate C-P lyase system protein PhnK UGYR_12190 ENOG4105FT8 Phosphonate metabolism UGYR_12195 ENOG4105EKV Phosphonate metabolism protein UGYR_12200 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH UGYR_12205 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG UGYR_12210 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) UGYR_12215 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase UGYR_12220 ENOG4105DBV ornithine carbamoyltransferase UGYR_12225 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) UGYR_12230 ENOG4108MJ3 acetyltransferase UGYR_12240 ENOG4105MYG DNA polymerase iii, chi subunit UGYR_12245 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) UGYR_12250 ENOG4108M8S permease YjgP YjgQ family protein UGYR_12255 ENOG4108K5H permease YjgP YjgQ family protein UGYR_12270 ENOG4107SCJ type I restriction enzyme EcoKI subunit R UGYR_12290 ENOG4108YUH UGYR_12300 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 UGYR_12345 ENOG4106H6R UPF0380 protein UGYR_12350 ENOG4106549 Antirestriction protein UGYR_12360 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles UGYR_12380 ENOG41090WB Transposase is3 is911 UGYR_12505 ENOG4105MFG Antirestriction protein UGYR_12515 ENOG4108QGT oligogalacturonate-specific porin UGYR_12540 ENOG4105CBG Sulfatase UGYR_12550 ENOG4105E98 transcriptional regulator DeoR family UGYR_12555 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of UGYR_12560 ENOG4105E70 isomerase UGYR_12565 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB UGYR_12570 ENOG4105ETZ PTS System UGYR_12575 ENOG4105F3R pts system mannose fructose sorbose family iid UGYR_12585 ENOG4105CE4 GlcNAc 6-P deacetylase UGYR_12595 ENOG4105CHR reductase UGYR_12605 ENOG4105C4X radical SAM domain protein UGYR_12610 ENOG4105ENH Sulfatase UGYR_12620 ENOG4105D2N Aldolase UGYR_12630 ENOG4105RI1 glycoprotein receptor UGYR_12635 ENOG4105DKP glycosyl transferase, family 9 UGYR_12650 ENOG410624X efflux transporter, rnd family, mfp subunit UGYR_12655 ENOG4105BZS acriflavin resistance protein UGYR_12665 ENOG4105CMT Dihydroxyacetone kinase UGYR_12670 ENOG4108UTZ Dihydroxyacetone kinase UGYR_12675 ENOG4105VDH Dihydroxyacetone kinase UGYR_12685 ENOG4105BZU Histidine kinase UGYR_12690 ENOG4105YBH Protein of unknown function (DUF1435) UGYR_12715 ENOG4108WPU DNA polymerase III subunit psi UGYR_12720 ENOG4105KEG ribosomal-protein-alanine acetyltransferase UGYR_12730 ENOG4105K3G Periplasmic Protein UGYR_12735 ENOG4108NRW Phospholipase, patatin family UGYR_12740 ENOG4105EYA deoxyribonuclease UGYR_12745 ENOG4105D9N nucleoside UGYR_12750 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) UGYR_12760 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) UGYR_12770 ENOG41062Z9 Membrane UGYR_12775 ENOG4105EAC phosphoserine phosphatase UGYR_12780 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) UGYR_12785 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase UGYR_12790 ENOG4105C5H ABC transporter UGYR_12810 ENOG4107SC1 transglycosylase UGYR_12815 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) UGYR_12820 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) UGYR_12825 ENOG4105CVJ phosphoglycerate mutase UGYR_12830 ENOG4105UEI Transcriptional Regulator AraC Family UGYR_12835 ENOG4108RH0 Crea protein UGYR_12840 ENOG41065U4 response regulator UGYR_12865 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) UGYR_12870 ENOG4108RIR Molybdenum cofactor biosynthesis protein UGYR_12875 ENOG4105CSH Transporter UGYR_12885 ENOG4106HK8 GPR1 FUN34 yaaH family protein UGYR_12890 ENOG4105CFG Acts as a chaperone (By similarity) UGYR_12900 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) UGYR_12905 ENOG41063Z6 transcriptional regulator, lysR family UGYR_12915 ENOG4105DTN riboflavin biosynthesis protein ribF UGYR_12925 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) UGYR_12930 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase UGYR_12935 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) UGYR_12945 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain UGYR_12950 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain UGYR_12955 ENOG410829K Lysine exporter protein (Lyse ygga) UGYR_12960 ENOG4105DWK Membrane UGYR_12970 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) UGYR_12985 ENOG4105NWN ApaG protein UGYR_12990 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) UGYR_12995 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) UGYR_13000 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) UGYR_13005 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) UGYR_13015 ENOG4105D3G Pseudouridine synthase UGYR_13020 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) UGYR_13025 ENOG4105CQ2 DNA polymerase UGYR_13030 ENOG4108KF1 Membrane UGYR_13040 ENOG4106SMU thiamine transporter membrane protein UGYR_13045 ENOG4105DP9 ABC transporter UGYR_13055 ENOG4105S8Q sugar efflux transporter UGYR_13065 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) UGYR_13070 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) UGYR_13080 ENOG41064T2 transcriptional regulator, lysR family UGYR_13085 ENOG4108IQE Amp-dependent synthetase and ligase UGYR_13090 ENOG4105C7K acetolactate synthase UGYR_13095 ENOG4108ZP8 Acetolactate synthase small subunit UGYR_13100 ENOG4107B7Y DNA-binding transcriptional regulator FruR UGYR_13105 ENOG4108RS6 transposase UGYR_13110 ENOG4105D7V transposase UGYR_13125 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) UGYR_13130 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) UGYR_13135 ENOG4105CJN penicillin-binding protein UGYR_13140 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) UGYR_13145 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) UGYR_13160 ENOG4105CNI cell division protein FtsW UGYR_13165 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) UGYR_13170 ENOG4105DFU Cell wall formation (By similarity) UGYR_13180 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) UGYR_13185 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) UGYR_13190 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) UGYR_13205 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) UGYR_13215 ENOG4105M6F mutator MutT protein UGYR_13230 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) UGYR_13235 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) UGYR_13240 ENOG4105D7Q type ii secretion system UGYR_13245 ENOG4107QHF type ii secretion system protein e UGYR_13250 ENOG4108ZUW Major pilin subunit UGYR_13255 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase UGYR_13265 ENOG4106A72 regulatory protein AmpE UGYR_13270 ENOG4105C85 amino acid UGYR_13275 ENOG41073TP transcriptional regulator UGYR_13280 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) UGYR_13285 ENOG4107QSN dihydrolipoamide acetyltransferase UGYR_13290 ENOG4107QN2 dihydrolipoyl dehydrogenase UGYR_13300 ENOG4107QIJ Aconitate hydratase 2 UGYR_13305 ENOG4108ZIG UPF0231 protein UGYR_13320 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) UGYR_13325 ENOG4108ZRK uncharacterized protein yacC UGYR_13330 ENOG4105E3B Multicopper oxidase UGYR_13335 ENOG4108UGV hypoxanthine phosphoribosyltransferase UGYR_13340 ENOG41077A9 carbonic anhydrase UGYR_13345 ENOG4105DA5 (ABC) transporter UGYR_13350 ENOG4105E3A (ABC) transporter UGYR_13355 ENOG4107BJW polysaccharide deacetylase UGYR_13360 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) UGYR_13365 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) UGYR_13370 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) UGYR_13375 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase UGYR_13380 ENOG4105DJ0 Poly(A) Polymerase UGYR_13390 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters UGYR_13395 ENOG4105PW4 Sugar fermentation stimulation protein homolog UGYR_13400 ENOG4107XID 2'-5' rna ligase UGYR_13405 ENOG4105CQ7 ATP-dependent helicase UGYR_13410 ENOG4105BZ4 penicillin-binding protein UGYR_13415 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase UGYR_13425 ENOG4108YX9 iron--sulfur cluster insertion protein erpA UGYR_13430 ENOG4105EN6 Membrane UGYR_13440 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) UGYR_13445 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein UGYR_13450 ENOG4105C0H protease UGYR_13455 ENOG4105BZU Histidine kinase UGYR_13460 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) UGYR_13465 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) UGYR_13470 ENOG4105DXN mazG family UGYR_13475 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) UGYR_13485 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) UGYR_13490 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase UGYR_13495 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) UGYR_13520 ENOG4108MXK alkaline phosphatase isozyme conversion UGYR_13525 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) UGYR_13530 ENOG4105C11 sulfate adenylyltransferase), subunit 2 UGYR_13535 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) UGYR_13540 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) UGYR_13545 ENOG4105N0Z inner membrane protein ygbE UGYR_13550 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) UGYR_13560 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) UGYR_13565 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) UGYR_13570 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) UGYR_13580 ENOG4108K5P (LipO)protein UGYR_13585 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) UGYR_13590 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) UGYR_13650 ENOG4105BZU Histidine kinase UGYR_13655 ENOG4105WH1 Two component transcriptional regulator luxr family UGYR_13670 ENOG4105K5T PilT protein UGYR_13690 ENOG4108RBT type iii secretion UGYR_13710 ENOG4108KB1 transcriptional regulator, arac family UGYR_13715 ENOG4105K44 type iii secretion UGYR_13720 ENOG4108N8R Invasion protein UGYR_13725 ENOG4108HR8 type iii secretion UGYR_13735 ENOG4108JIR Flagellum-specific ATP synthase UGYR_13750 ENOG4105T85 surface presentation of antigens protein UGYR_13755 ENOG41075IY surface presentation of antigens protein SpaP UGYR_13765 ENOG4108TN6 type iii secretion UGYR_13800 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) UGYR_13820 ENOG4108M1A Chitin-binding protein UGYR_13825 ENOG4105XQF Lipoprotein UGYR_13830 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) UGYR_13855 ENOG4105X5Z General secretion pathway protein I UGYR_13870 ENOG4105D7Q type ii secretion system UGYR_13875 ENOG4107QHF type ii secretion system protein e UGYR_13885 ENOG4108XKW General secretion pathway protein C UGYR_13910 ENOG4107GFK fumarate UGYR_13915 ENOG4108ISG Major Facilitator UGYR_13925 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) UGYR_13930 ENOG4105Y3E Modulates RecA activity (By similarity) UGYR_13935 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) UGYR_13940 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) UGYR_13965 ENOG4107VXZ Hydrolase UGYR_13970 ENOG4105W39 Membrane UGYR_13975 ENOG4105D9M gamma-glutamylcysteine synthetase UGYR_13980 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) UGYR_13985 ENOG4108JU6 CBS domain protein UGYR_13990 ENOG4106KVJ cytochrome C assembly protein UGYR_13995 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY UGYR_14000 ENOG4105K5M 30s ribosomal protein S16 UGYR_14005 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) UGYR_14010 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) UGYR_14015 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) UGYR_14020 ENOG4108NE3 Salt-induced outer membrane protein UGYR_14025 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter UGYR_14030 ENOG4108NEV two component transcriptional regulator, LytTR family UGYR_14035 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) UGYR_14050 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA UGYR_14055 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane UGYR_14060 ENOG4105C34 Pseudouridine synthase UGYR_14065 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase UGYR_14105 ENOG4107NA1 Endonuclease Exonuclease phosphatase UGYR_14110 ENOG4105E9H Lytic Murein transglycosylase UGYR_14120 ENOG4105D1A Methyltransferase UGYR_14130 ENOG4107RZZ dna polymerase iii epsilon subunit UGYR_14140 ENOG4107QPN acyl-Coa dehydrogenase UGYR_14145 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) UGYR_14150 ENOG4105E7A Glutamine amidotransferase UGYR_14155 ENOG4105F7V ErfK ybiS ycfS ynhG family protein UGYR_14160 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) UGYR_14165 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) UGYR_14170 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) UGYR_14175 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) UGYR_14180 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) UGYR_14190 ENOG4105CJ2 (LipO)protein UGYR_14205 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) UGYR_14210 ENOG4105CIN aminoacyl-histidine dipeptidase UGYR_14215 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) UGYR_14220 ENOG4105V1F Fermentation respiration switch protein UGYR_14225 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) UGYR_14260 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) UGYR_14270 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) UGYR_14290 ENOG4105HBA AroM protein UGYR_14300 ENOG4105DH7 May be involved in recombination (By similarity) UGYR_14305 ENOG4105DKQ ROK family UGYR_14310 ENOG4105EYH Exonuclease UGYR_14320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family UGYR_14325 ENOG4105BZU Histidine kinase UGYR_14335 ENOG4105CWM branched-chain amino acid transport system II carrier protein UGYR_14340 ENOG4105C85 amino acid UGYR_14345 ENOG4107R28 alpha amylase, catalytic region UGYR_14350 ENOG4108RKS Short-chain dehydrogenase reductase Sdr UGYR_14355 ENOG4105D3R alkyl hydroperoxide reductase UGYR_14360 ENOG4108ZYK Acyl carrier protein phosphodiesterase UGYR_14365 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) UGYR_14375 ENOG4105VIE preprotein translocase, subunit YajC UGYR_14380 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) UGYR_14385 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) UGYR_14390 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) UGYR_14395 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) UGYR_14400 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) UGYR_14410 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) UGYR_14415 ENOG4108ZAI phosphatidylglycerophosphatase a UGYR_14420 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) UGYR_14425 ENOG4105CTB Polyprenyl synthetase UGYR_14440 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta UGYR_14450 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC UGYR_14455 ENOG4105CXY transporter UGYR_14460 ENOG4107S0N DJ-1 family UGYR_14465 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) UGYR_14470 ENOG4108VPT UPF0234 protein UGYR_14475 ENOG4107RDB Major Facilitator UGYR_14485 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) UGYR_14490 ENOG4105CCU oxidase (Subunit III) UGYR_14495 ENOG4105BZ9 Cytochrome C oxidase, subunit I UGYR_14500 ENOG4105E2S oxidase) subunit II UGYR_14505 ENOG4108NFH Sugar hydrolase UGYR_14510 ENOG4105EYM Major Facilitator superfamily UGYR_14515 ENOG4105IEY (LipO)protein UGYR_14520 ENOG4105M85 Bola protein UGYR_14530 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) UGYR_14535 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) UGYR_14540 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) UGYR_14545 ENOG4105K70 DNA-binding protein UGYR_14550 ENOG4105EIN peptidylprolyl cis-trans isomerase UGYR_14555 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein UGYR_14560 ENOG4108TGP Thioesterase superfamily protein UGYR_14565 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) UGYR_14570 ENOG4108NFA extracellular solute-binding protein UGYR_14585 ENOG4108XM1 transcriptional regulator AsnC family UGYR_14590 ENOG4105BZ1 (ABC) transporter UGYR_14595 ENOG4105BZ1 (ABC) transporter UGYR_14600 ENOG4108YZA Nitrogen regulatory protein pii UGYR_14605 ENOG4105BZU Histidine kinase UGYR_14610 ENOG4105C29 acyl-CoA thioesterase UGYR_14615 ENOG41080UX Methyltransferase UGYR_14620 ENOG4105KF5 hemolysin expression-modulating protein UGYR_14625 ENOG4108UKR Biofilm formation regulator YbaJ UGYR_14635 ENOG4105NRA 50s ribosomal protein l31 type b UGYR_14640 ENOG4105BZS acriflavin resistance protein UGYR_14645 ENOG4105C1P efflux transporter, rnd family, mfp subunit UGYR_14650 ENOG4108IG5 Transcriptional regulator UGYR_14655 ENOG41090EX DsrE family UGYR_14660 ENOG4105EGS Mechanosensitive ion channel UGYR_14670 ENOG4105WD1 Membrane UGYR_14675 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) UGYR_14700 ENOG4105DHQ Histidine kinase UGYR_14705 ENOG4107QMP dna polymerase iii subunits gamma and tau UGYR_14715 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) UGYR_14720 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) UGYR_14735 ENOG4108QY5 Ferric enterobactin transport protein UGYR_14740 ENOG4107RE1 Inosine-guanosine kinase UGYR_14745 ENOG4105CKD glutathione-regulated potassium-efflux system protein UGYR_14750 ENOG4105CGH 5'-nucleotidase UGYR_14765 ENOG4108WF3 methyltransferase UGYR_14780 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase UGYR_14805 ENOG4108Z66 YbaK ebsC protein UGYR_14810 ENOG4105MBR gumn family UGYR_14815 ENOG4105C59 p-type ATPase UGYR_14820 ENOG4108Z6Z Transcriptional regulator UGYR_14825 ENOG4105G5H Membrane UGYR_14830 ENOG4107QX8 SPFH domain, Band 7 family protein UGYR_14835 ENOG4107QR8 Thioredoxin UGYR_14840 ENOG4105E1F short-chain dehydrogenase reductase UGYR_14845 ENOG4108UJV acyl-CoA thioesterase i UGYR_14850 ENOG4108I0Y (ABC) transporter UGYR_14855 ENOG4105CV6 ABC transporter, permease UGYR_14860 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit UGYR_14865 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) UGYR_14875 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) UGYR_14900 ENOG4106PG1 outer membrane usher protein UGYR_14905 ENOG4108FZ9 Chaperone UGYR_14935 ENOG4105WQ3 Rna-binding protein UGYR_14940 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) UGYR_14970 ENOG4108IQE Amp-dependent synthetase and ligase UGYR_14995 ENOG4105CPW cytochrome b561 UGYR_15005 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) UGYR_15015 ENOG4108VYJ response regulator receiver protein UGYR_15035 ENOG4107QZ7 Cellulose synthase catalytic subunit UGYR_15060 ENOG4105BZU Histidine kinase UGYR_15065 ENOG4105BZU Histidine kinase UGYR_15070 ENOG4108XFH Transcriptional regulator UGYR_15095 ENOG4108N8T regulatoR UGYR_15105 ENOG4105VEQ Cold shock protein UGYR_15120 ENOG4105BZU Histidine kinase UGYR_15125 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) UGYR_15130 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) UGYR_15145 ENOG4105DZ1 carboxypeptidase UGYR_15150 ENOG4105K6T rare lipoprotein A UGYR_15155 ENOG4105CNI cell division protein FtsW UGYR_15160 ENOG4105CJN penicillin-binding protein UGYR_15165 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) UGYR_15170 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) UGYR_15175 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) UGYR_15180 ENOG4105DJF DNA polymerase III, delta' subunit UGYR_15185 ENOG4108U2H Rare lipoprotein B UGYR_15195 ENOG4107PAI alpha helical protein UGYR_15200 ENOG4105CDA abc transporter atp-binding protein UGYR_15205 ENOG4105DRP amino acid AbC transporter UGYR_15210 ENOG4105EAD ABC transporter UGYR_15215 ENOG4107RP9 extracellular solute-binding protein, family 3 UGYR_15225 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) UGYR_15230 ENOG4108JU5 Magnesium and cobalt efflux protein UGYR_15235 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) UGYR_15240 ENOG4105C9A Phoh family UGYR_15245 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) UGYR_15250 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family UGYR_15285 ENOG4105CAQ asparagine synthetase UGYR_15290 ENOG4105D4U had-superfamily hydrolase, subfamily iia UGYR_15295 ENOG4105E2R ROK family UGYR_15300 ENOG4105CE4 GlcNAc 6-P deacetylase UGYR_15305 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) UGYR_15310 ENOG4105CI1 PTS System UGYR_15325 ENOG4105GX6 (LipO)protein UGYR_15335 ENOG41090R7 Ferric uptake UGYR_15340 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) UGYR_15345 ENOG4105C8Q Methyl-accepting chemotaxis UGYR_15350 ENOG4105NNH LexA regulated protein UGYR_15355 ENOG4105EV9 Alpha Beta Hydrolase UGYR_15365 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 UGYR_15375 ENOG4105EEX Two component transcriptional regulator (Winged helix family UGYR_15380 ENOG4105C08 Histidine kinase UGYR_15385 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) UGYR_15390 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) UGYR_15405 ENOG4105XIQ Protein of unknown function (DUF2517) UGYR_15410 ENOG4107SEY Conserved Protein UGYR_15415 ENOG4105CVP deoxyribo-dipyrimidine photolyase UGYR_15420 ENOG4107RF4 Phosphodiesterase UGYR_15425 ENOG4107QNR UPF0135 protein UGYR_15430 ENOG4105P4J Allophanate hydrolase, subunit 1 UGYR_15435 ENOG4107R7A Allophanate hydrolase subunit 2 UGYR_15440 ENOG4105E7W lamb ycsf family protein UGYR_15465 ENOG4105BZN citrate synthase UGYR_15470 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit UGYR_15475 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein UGYR_15485 ENOG4105E33 succinate dehydrogenase UGYR_15490 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 UGYR_15495 ENOG4105C7S Dehydrogenase UGYR_15500 ENOG4105CMV Succinyl-CoA synthetase subunit beta UGYR_15505 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha UGYR_15510 ENOG4105CGH 5'-nucleotidase UGYR_15515 ENOG4105C4M (Ubiquinol oxidase) subunit I UGYR_15520 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii UGYR_15530 ENOG4105KJB cyd operon protein YbgE UGYR_15535 ENOG4107YD3 Thioesterase UGYR_15540 ENOG4105E02 MotA TolQ exbB proton channel UGYR_15545 ENOG4105M8F Biopolymer transport protein exbD tolR UGYR_15550 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA UGYR_15550 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA UGYR_15555 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) UGYR_15560 ENOG4105KCK Peptidoglycan-associated lipoprotein UGYR_15565 ENOG4105UFD tol-pal system protein YbgF UGYR_15590 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) UGYR_15595 ENOG4106Z1T Nicotinamide Mononucleotide Transporter UGYR_15600 ENOG4105BZU Histidine kinase UGYR_15605 ENOG4107ZHV Transcriptional regulator UGYR_15610 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) UGYR_15615 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) UGYR_15625 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) UGYR_15635 ENOG4105F0Z galactose-1-phosphate uridylyltransferase UGYR_15640 ENOG4105CMR udp-glucose 4-epimerase UGYR_15650 ENOG4105F4R Transcriptional regulator mode UGYR_15655 ENOG410680R Protein of unknown function (DUF2592) UGYR_15660 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein UGYR_15665 ENOG4105E0C molybdate abc transporter UGYR_15675 ENOG4108K4B hydrolase UGYR_15680 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) UGYR_15695 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) UGYR_15700 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) UGYR_15705 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) UGYR_15715 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) UGYR_15720 ENOG4105VYA Uncharacterized conserved protein (DUF2132) UGYR_15735 ENOG4105EHG Permease protein UGYR_15740 ENOG4108W0P ABC transporter UGYR_15745 ENOG4105CHW UPF0052 protein UGYR_15750 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) UGYR_15755 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) UGYR_15760 ENOG4105M00 molybdopterin converting factor, subunit 1 UGYR_15765 ENOG4108ZAF Molybdopterin UGYR_15770 ENOG4105HFZ Membrane UGYR_15775 ENOG4107QWP ABC-2 type transporter UGYR_15780 ENOG4107QWP ABC-2 type transporter UGYR_15785 ENOG4105CJ1 ABC, transporter UGYR_15790 ENOG4105D0S secretion protein (HlyD UGYR_15795 ENOG4107MVR Transcriptional regulator UGYR_15800 ENOG4105C1J atp-dependent rna helicase UGYR_15805 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) UGYR_15815 ENOG41061WM D-Alanyl-D-Alanine UGYR_15820 ENOG4105CXG d-lactate dehydrogenase UGYR_15830 ENOG4105N1F Hnh endonuclease UGYR_15840 ENOG4105Y3U Transglycosylase-associated protein UGYR_15850 ENOG4105EHI Phosphonate ABC transporter, periplasmic UGYR_15865 ENOG4108W15 Protein of unknown function (DUF1456) UGYR_15870 ENOG4105KHC sulfurtransferase UGYR_15875 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system UGYR_15880 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component UGYR_15885 ENOG4108IJ8 ABC transporter UGYR_15890 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component UGYR_15895 ENOG4105D5Q Arginine ornithine antiporter UGYR_15900 ENOG4105CXN decarboxylase UGYR_15910 ENOG4105FDR Membrane UGYR_15920 ENOG4105DVT helicase UGYR_15925 ENOG4108MTB glycosyl transferase family UGYR_15930 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) UGYR_15935 ENOG4105CDA abc transporter atp-binding protein UGYR_15940 ENOG4105E5Q amino acid AbC transporter UGYR_15945 ENOG4107R0W ABC transporter UGYR_15960 ENOG4107AQZ Membrane UGYR_15965 ENOG4108T1M outer membrane protein x UGYR_15970 ENOG4105CJW magnesium transporter UGYR_15985 ENOG4105C5H ABC transporter UGYR_15990 ENOG4105D06 uba thif-type nad fad binding protein UGYR_15995 ENOG4105CVM Molybdenum cofactor synthesis domain protein UGYR_16015 ENOG4105EGI Transcriptional regulator UGYR_16020 ENOG4105CBP Major Facilitator UGYR_16025 ENOG4105EUJ GTP cyclohydrolase i UGYR_16030 ENOG4105DHF Membrane UGYR_16035 ENOG41060NJ transcriptional regulator UGYR_16050 ENOG4107SDZ Galactoside transport system permease protein mglC UGYR_16055 ENOG4107GZ4 SanA protein UGYR_16060 ENOG4107R1I NAD-dependent malic enzyme UGYR_16080 ENOG41067MG lrgb family UGYR_16085 ENOG4105VAW lrga family UGYR_16095 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) UGYR_16100 ENOG4105D1F ATP-binding protein UGYR_16105 ENOG4105DBI uridine monophosphokinase UGYR_16110 ENOG4105DHP deoxycytidine triphosphate deaminase UGYR_16115 ENOG4108GAE asmA family UGYR_16120 ENOG4105CEE C4-dicarboxylate transporter UGYR_16125 ENOG4105EE5 Membrane protein terC UGYR_16130 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase UGYR_16135 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase UGYR_16140 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) UGYR_16145 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase UGYR_16155 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase UGYR_16160 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) UGYR_16165 ENOG4105ECC imidazole-glycerol-phosphate dehydratase UGYR_16170 ENOG4105CIH Imidazole acetol-phosphate transaminase UGYR_16175 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) UGYR_16185 ENOG4108535 NAD dependent epimerase/dehydratase family UGYR_16190 ENOG4108TGY Glutathione S-transferase UGYR_16205 ENOG4105C28 cystathionine UGYR_16215 ENOG4105DZ1 carboxypeptidase UGYR_16220 ENOG4105EJQ L-serine dehydratase UGYR_16225 ENOG4105C44 Serine transporter UGYR_16230 ENOG4107FB0 transcriptional regulator DeoR family UGYR_16240 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase UGYR_16250 ENOG4105D0C transport protein UGYR_16255 ENOG41090BQ Glutaredoxin UGYR_16260 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress UGYR_16265 ENOG4108RMJ sensory transduction regulator UGYR_16270 ENOG4107RUE extracellular solute-binding protein family 1 UGYR_16275 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) UGYR_16280 ENOG4105F38 ABC transporter, permease UGYR_16285 ENOG4105D38 putrescine abc transporter UGYR_16290 ENOG4105RBQ inner membrane protein ybjO UGYR_16300 ENOG4106TNF Periplasmic binding protein UGYR_16305 ENOG4105DMR ABC, transporter UGYR_16310 ENOG4105GBT ABC transporter UGYR_16315 ENOG4106PMH Extracellular solute-binding protein family 3 UGYR_16320 ENOG4105E5Z arginine transporter ATP-binding subunit UGYR_16325 ENOG41064MM (LipO)protein UGYR_16330 ENOG4105K8R UPF0145 protein UGYR_16335 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase UGYR_16340 ENOG4105CGD Nad-dependent epimerase dehydratase UGYR_16345 ENOG4105C5W Aldolase UGYR_16350 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) UGYR_16355 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) UGYR_16360 ENOG4105DWU Membrane UGYR_16365 ENOG4105CPB ATP-dependent endonuclease of the OLD family UGYR_16375 ENOG4105DJY efflux transporter, rnd family, mfp subunit UGYR_16385 ENOG4105VEQ Cold shock protein UGYR_16390 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) UGYR_16395 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit UGYR_16400 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) UGYR_16410 ENOG4108JJ8 (ABC) transporter UGYR_16415 ENOG4108JJ9 ABC, transporter UGYR_16420 ENOG4105C3M thioredoxin reductase UGYR_16425 ENOG4105EW9 transcriptional regulator AsnC family UGYR_16430 ENOG4105CNU cell division protein FtsK UGYR_16435 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) UGYR_16440 ENOG4105D1H recombination factor protein RarA UGYR_16445 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) UGYR_16450 ENOG4108ISG Major Facilitator UGYR_16455 ENOG4105F1A Pyruvate formate-lyase UGYR_16460 ENOG4105C6N Formate acetyltransferase UGYR_16465 ENOG4105TMB Formate nitrite transporter UGYR_16470 ENOG4105DDY UPF0142 protein ycaO UGYR_16475 ENOG4105HDK L-asparaginase UGYR_16495 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) UGYR_16505 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 UGYR_16515 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) UGYR_16520 ENOG4105E32 cytoplasmic protein UGYR_16525 ENOG4105VEQ Cold shock protein UGYR_16530 ENOG4105VEQ Cold shock protein UGYR_16535 ENOG4105W49 UPF0434 protein UGYR_16540 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) UGYR_16545 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups UGYR_16550 ENOG4107S90 membrAne UGYR_16555 ENOG4106371 Methyltransferase UGYR_16560 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) UGYR_16565 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) UGYR_16570 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) UGYR_16575 ENOG4105DIT ErfK YbiS YcfS YnhG family protein UGYR_16580 ENOG4105EAQ (twin-arginine translocation) pathway signal UGYR_16585 ENOG4105C5X domain protein UGYR_16590 ENOG4105CGF Aromatic amino acid aminotransferase