locus-tag	class	description
YR821_0002	COG0592	DNA-directed DNA polymerase activity
YR821_0005	COG0187	DNA topoisomerase II activity
YR821_0006	COG0561	phosphatase activity
YR821_0007	COG0823	Involved in the tonB-independent uptake of proteins
YR821_0008	COG5645	(Lipo)protein
YR821_0011	COG0569	domain protein
YR821_0011	COG2985	domain, Protein
YR821_0012	COG3977	Valine--pyruvate aminotransferase
YR821_0013	COG2885	chlorophyll binding
YR821_0018	COG2818	Glycosylase
YR821_0028	COG2213	PTS system mannitol-specific
YR821_0028	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
YR821_0030	COG3722	fumarate hydratase activity
YR821_0032	COG2258	MOSC domain
YR821_0033	COG0840	transmembrane signaling receptor activity
YR821_0034	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YR821_0037	COG0437	4 iron, 4 sulfur cluster binding
YR821_0038	COG2864	formate dehydrogenase
YR821_0040	COG1921	L-seryl-tRNASec selenium transferase activity
YR821_0041	COG3276	selenocysteine insertion sequence binding
YR821_0042	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
YR821_0044	COG3274	enterobacterial common antigen metabolic process
YR821_0045	COG0582	viral genome integration into host DNA
YR821_0046	COG2801	Transposase and inactivated derivatives
YR821_0053	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
YR821_0054	COG2986	histidine ammonia-lyase
YR821_0058	COG2194	sulfuric ester hydrolase activity
YR821_0059	COG2197	response regulator
YR821_0060	COG3851	Histidine kinase
YR821_0061	COG2271	Major facilitator Superfamily
YR821_0062	COG0747	negative chemotaxis
YR821_0063	COG0601	transmembrane transport
YR821_0064	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YR821_0065	COG0444	Belongs to the ABC transporter superfamily
YR821_0066	COG4608	Belongs to the ABC transporter superfamily
YR821_0067	COG2194	sulfuric ester hydrolase activity
YR821_0073	COG1215	transferase activity, transferring glycosyl groups
YR821_0074	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
YR821_0075	COG3118	belongs to the thioredoxin family
YR821_0075	COG0457	Tetratricopeptide repeat
YR821_0076	COG2200	EAL domain
YR821_0076	COG2199	diguanylate cyclase activity
YR821_0077	COG1301	dicarboxylic acid transport
YR821_0078	COG0612	Peptidase, M16
YR821_0079	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YR821_0080	COG1942	4-Oxalocrotonate Tautomerase
YR821_0081	COG2200	EAL domain
YR821_0082	COG2134	cdp-diacylglycerol pyrophosphatase
YR821_0083	COG1295	ribonuclease BN
YR821_0085	COG1301	dicarboxylic acid transport
YR821_0086	COG0626	cystathionine gamma-synthase activity
YR821_0090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YR821_0091	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
YR821_0092	COG0339	signal peptide processing
YR821_0093	COG0742	ribosomal rna small subunit methyltransferase
YR821_0095	COG0589	response to stress
YR821_0097	COG0306	phosphate transporter
YR821_0099	COG2081	HI0933 family
YR821_0107	COG5499	transcription regulator containing HTH domain
YR821_0109	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YR821_0114	COG2963	transposase activity
YR821_0115	COG2801	Transposase and inactivated derivatives
YR821_0134	COG1247	-acetyltransferase
YR821_0137	COG1741	Belongs to the pirin family
YR821_0138	COG1609	Transcriptional regulator
YR821_0139	COG2610	gluconate transmembrane transporter activity
YR821_0140	COG3265	gluconokinase activity
YR821_0141	COG2095	MarC family integral membrane protein
YR821_0142	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YR821_0143	COG3275	phosphorelay sensor kinase activity
YR821_0144	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
YR821_0145	COG1523	belongs to the glycosyl hydrolase 13 family
YR821_0146	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
YR821_0147	COG0297	glycogen (starch) synthase activity
YR821_0148	COG0058	SHG alpha-glucan phosphorylase activity
YR821_0150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YR821_0151	COG1349	DNA-binding transcription factor activity
YR821_0152	COG0705	Rhomboid family
YR821_0154	COG2909	trisaccharide binding
YR821_0155	COG0058	SHG alpha-glucan phosphorylase activity
YR821_0156	COG1640	4-alpha-glucanotransferase
YR821_0158	COG1040	competence protein
YR821_0159	COG0596	Alpha beta hydrolase
YR821_0163	COG1918	ferrous iron import across plasma membrane
YR821_0164	COG2183	response to ionizing radiation
YR821_0169	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YR821_0172	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
YR821_0174	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
YR821_0175	COG1011	Hydrolase
YR821_0177	COG0494	nUDIX hydrolase
YR821_0178	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
YR821_0183	COG4796	Type ii and iii secretion system protein
YR821_0184	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
YR821_0188	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
YR821_0190	COG0180	Tryptophanyl-tRNA synthetase
YR821_0194	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YR821_0195	COG0402	S-adenosylhomocysteine deaminase activity
YR821_0196	COG0738	Major facilitator superfamily
YR821_0199	COG1609	Transcriptional regulator
YR821_0200	COG1486	melibiose metabolic process
YR821_0202	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YR821_0206	COG1289	transmembrane transporter activity
YR821_0207	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YR821_0208	COG1765	OsmC-like protein
YR821_0209	COG0675	Transposase, IS605 OrfB family
YR821_0213	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YR821_0214	COG3954	Phosphoribulokinase
YR821_0216	COG0429	hydrolase of the alpha beta-hydrolase fold
YR821_0218	COG0859	PFAM glycosyl transferase family 9
YR821_0219	COG1216	Glycosyl transferase, family 2
YR821_0220	COG0488	(ABC) transporter
YR821_0221	COG2249	NAD(P)H dehydrogenase (quinone) activity
YR821_0223	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
YR821_0224	COG1047	Peptidyl-prolyl cis-trans
YR821_0226	COG0545	Peptidyl-prolyl cis-trans isomerase
YR821_0227	COG2964	Protein conserved in bacteria
YR821_0229	COG2923	Belongs to the DsrF TusC family
YR821_0230	COG2168	tRNA wobble position uridine thiolation
YR821_0231	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
YR821_0232	COG0049	tRNA binding
YR821_0234	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
YR821_0237	COG0051	transcription antitermination factor activity, RNA binding
YR821_0238	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
YR821_0240	COG0089	rRNA binding
YR821_0241	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
YR821_0242	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YR821_0243	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
YR821_0245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YR821_0246	COG0255	Belongs to the universal ribosomal protein uL29 family
YR821_0247	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
YR821_0248	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YR821_0250	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
YR821_0255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
YR821_0256	COG1841	ribosomal large subunit assembly
YR821_0257	COG0200	Binds to the 23S rRNA
YR821_0258	COG0201	protein transport
YR821_0259	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YR821_0260	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
YR821_0262	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YR821_0264	COG0203	ribosomal protein L17
YR821_0265	COG0789	Transcriptional regulator
YR821_0266	COG3036	rescue of stalled ribosome
YR821_0267	COG1970	mechanosensitive ion channel activity
YR821_0269	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
YR821_0269	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
YR821_0270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
YR821_0271	COG0242	peptide deformylase activity
YR821_0272	COG0758	DNA mediated transformation
YR821_0273	COG2922	Belongs to the Smg family
YR821_0274	COG0551	DNA topoisomerase type I activity
YR821_0275	COG0009	L-threonylcarbamoyladenylate synthase
YR821_0277	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YR821_0279	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YR821_0280	COG3162	membrane
YR821_0281	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YR821_0282	COG1301	dicarboxylic acid transport
YR821_0283	COG2391	methyltransferase activity
YR821_0284	COG0425	Belongs to the sulfur carrier protein TusA family
YR821_0286	COG2963	transposase activity
YR821_0287	COG1086	Polysaccharide biosynthesis protein
YR821_0288	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YR821_0289	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
YR821_0290	COG2089	acid synthase
YR821_0294	COG2755	lipolytic protein G-D-S-L family
YR821_0294	COG1083	cytidylyl-transferase
YR821_0295	COG1028	Short-chain dehydrogenase reductase Sdr
YR821_0299	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YR821_0299	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YR821_0300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
YR821_0304	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
YR821_0307	COG1309	transcriptional regulator
YR821_0308	COG4232	protein-disulfide reductase activity
YR821_0310	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YR821_0316	COG1509	lysine 2,3-aminomutase activity
YR821_0318	COG3397	chitin binding
YR821_0322	COG3188	usher protein
YR821_0327	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
YR821_0328	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
YR821_0329	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
YR821_0330	COG1053	succinate dehydrogenase
YR821_0332	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
YR821_0333	COG3264	Mechanosensitive ion channel
YR821_0333	COG1511	domain protein
YR821_0334	COG0688	phosphatidylethanolamine metabolic process
YR821_0335	COG1162	GTPase activity
YR821_0336	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
YR821_0337	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
YR821_0338	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YR821_0338	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
YR821_0339	COG0802	atpase or kinase
YR821_0340	COG0860	N-Acetylmuramoyl-L-alanine amidase
YR821_0342	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
YR821_0344	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YR821_0345	COG0330	HflC and HflK could
YR821_0346	COG0330	HflC and HflK could
YR821_0347	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
YR821_0348	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
YR821_0349	COG1959	2 iron, 2 sulfur cluster binding
YR821_0350	COG0557	exoribonuclease II activity
YR821_0351	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YR821_0355	COG3121	Chaperone
YR821_0356	COG3188	usher protein
YR821_0360	COG1073	alpha beta
YR821_0362	COG0360	Binds together with S18 to 16S ribosomal RNA
YR821_0363	COG2965	DNA replication, synthesis of RNA primer
YR821_0364	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
YR821_0365	COG0359	binds to the 23S rRNA
YR821_0366	COG3061	Opacity-associated protein A
YR821_0367	COG0545	Peptidyl-prolyl cis-trans isomerase
YR821_0369	COG0737	Belongs to the 5'-nucleotidase family
YR821_0370	COG2963	transposase activity
YR821_0372	COG1218	3'(2'),5'-bisphosphate nucleotidase
YR821_0373	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
YR821_0375	COG1253	flavin adenine dinucleotide binding
YR821_0376	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YR821_0377	COG0729	surface antigen
YR821_0378	COG2911	Protein conserved in bacteria
YR821_0379	COG2105	PFAM AIG2 family protein
YR821_0380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YR821_0382	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YR821_0385	COG3423	Transcriptional regulator
YR821_0388	COG0142	geranyltranstransferase activity
YR821_0391	COG0697	spore germination
YR821_0392	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
YR821_0393	COG0642	Histidine kinase
YR821_0394	COG0745	RESPONSE REGULATOR receiver
YR821_0395	COG2027	D-alanyl-D-alanine carboxypeptidase
YR821_0397	COG1534	Rna-binding protein
YR821_0398	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
YR821_0400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YR821_0401	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YR821_0402	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
YR821_0404	COG0195	Participates in both transcription termination and antitermination
YR821_0406	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
YR821_0409	COG1185	polyribonucleotide nucleotidyltransferase activity
YR821_0411	COG0513	Belongs to the DEAD box helicase family
YR821_0412	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YR821_0413	COG0814	amino acid
YR821_0415	COG0826	peptidase U32
YR821_0416	COG0826	peptidase U32
YR821_0417	COG3154	lipid carrier protein
YR821_0418	COG3153	acetyltransferase
YR821_0419	COG2827	Endonuclease containing a URI domain
YR821_0420	COG0531	amino acid
YR821_0421	COG1982	Orn Lys Arg decarboxylase major
YR821_0423	COG3787	Belongs to the UPF0306 family
YR821_0424	COG0702	epimerase
YR821_0425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YR821_0426	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
YR821_0427	COG3454	Phosphonate metabolism
YR821_0428	COG4778	phosphonate C-P lyase system protein PhnL
YR821_0429	COG4107	phosphonate C-P lyase system protein PhnK
YR821_0430	COG3627	carbon phosphorus lyase activity
YR821_0431	COG3626	phosphonate metabolism
YR821_0432	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
YR821_0433	COG3624	Phosphonate C-P lyase system protein PhnG
YR821_0437	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
YR821_0440	COG2927	DNA polymerase III (CHI subunit)
YR821_0441	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
YR821_0442	COG0795	lipopolysaccharide-transporting ATPase activity
YR821_0443	COG0795	lipopolysaccharide-transporting ATPase activity
YR821_0449	COG2963	transposase activity
YR821_0453	COG5492	domain, Protein
YR821_0457	COG3119	arylsulfatase activity
YR821_0459	COG1349	DNA-binding transcription factor activity
YR821_0461	COG2222	sugar isomerase
YR821_0462	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YR821_0463	COG3715	PTS system
YR821_0464	COG3716	PTS system mannose fructose sorbose family IID component
YR821_0466	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
YR821_0468	COG1028	Short-chain dehydrogenase reductase Sdr
YR821_0470	COG0641	radical SAM
YR821_0471	COG3119	arylsulfatase activity
YR821_0477	COG0859	PFAM glycosyl transferase family 9
YR821_0480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YR821_0481	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YR821_0483	COG2376	Dihydroxyacetone kinase
YR821_0484	COG1461	Dihydroxyacetone kinase
YR821_0485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YR821_0485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YR821_0485	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
YR821_0490	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
YR821_0493	COG2823	Periplasmic or secreted lipoprotein
YR821_0495	COG4667	esterase of the alpha-beta hydrolase superfamily
YR821_0496	COG0084	hydrolase, TatD family'
YR821_0497	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YR821_0501	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
YR821_0503	COG3726	membrane protein affecting hemolysin expression
YR821_0504	COG0560	Phosphoserine phosphatase
YR821_0507	COG0488	(ABC) transporter
YR821_0508	COG2885	chlorophyll binding
YR821_0512	COG0741	lytic transglycosylase activity
YR821_0513	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
YR821_0514	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
YR821_0515	COG0406	alpha-ribazole phosphatase activity
YR821_0516	COG2207	Transcriptional regulator
YR821_0516	COG3708	Transcriptional regulator
YR821_0517	COG3045	CreA protein
YR821_0518	COG0745	RESPONSE REGULATOR receiver
YR821_0524	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YR821_0525	COG0521	Mo-molybdopterin cofactor biosynthetic process
YR821_0526	COG0477	Major facilitator Superfamily
YR821_0528	COG1584	GPR1 FUN34 yaaH family protein
YR821_0530	COG0443	Heat shock 70 kDa protein
YR821_0532	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YR821_0533	COG0583	DNA-binding transcription factor activity
YR821_0535	COG0196	riboflavin kinase activity
YR821_0537	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
YR821_0538	COG1047	Peptidyl-prolyl cis-trans
YR821_0539	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
YR821_0542	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
YR821_0544	COG2966	Psort location CytoplasmicMembrane, score
YR821_0549	COG2967	ApaG domain
YR821_0550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
YR821_0551	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
YR821_0553	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YR821_0555	COG0564	pseudouridine synthase activity
YR821_0556	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YR821_0557	COG0417	DNA replication proofreading
YR821_0559	COG0586	Pfam SNARE associated Golgi protein
YR821_0561	COG1178	ABC-type Fe3 transport system permease component
YR821_0562	COG4143	(ABC) transporter
YR821_0566	COG2814	Major facilitator Superfamily
YR821_0568	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
YR821_0569	COG0473	3-isopropylmalate dehydrogenase activity
YR821_0574	COG1022	Amp-dependent synthetase and ligase
YR821_0576	COG0028	Belongs to the TPP enzyme family
YR821_0580	COG0675	Transposase, IS605 OrfB family
YR821_0583	COG0275	rRNA processing
YR821_0584	COG3116	cell division
YR821_0585	COG0768	penicillin binding
YR821_0586	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YR821_0587	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YR821_0590	COG0772	Belongs to the SEDS family
YR821_0591	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
YR821_0592	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YR821_0594	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
YR821_0595	COG0849	cell division
YR821_0596	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
YR821_0601	COG0494	nUDIX hydrolase
YR821_0605	COG0516	GMP reductase activity
YR821_0606	COG1459	type II secretion system
YR821_0607	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YR821_0608	COG4969	Belongs to the N-Me-Phe pilin family
YR821_0611	COG3725	Membrane protein required for beta-lactamase induction
YR821_0612	COG1113	amino acid transport
YR821_0615	COG2186	Transcriptional regulator
YR821_0616	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
YR821_0617	COG0508	dehydrogenase complex catalyzes the overall conversion of
YR821_0618	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YR821_0621	COG1049	propionate catabolic process, 2-methylcitrate cycle
YR821_0623	COG3112	Uncharacterised protein family (UPF0231)
YR821_0627	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
YR821_0629	COG2132	Multicopper oxidase
YR821_0631	COG0288	reversible hydration of carbon dioxide
YR821_0632	COG1131	(ABC) transporter
YR821_0633	COG0842	Transport permease protein
YR821_0635	COG0726	polysaccharide deacetylase
YR821_0636	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
YR821_0637	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
YR821_0638	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
YR821_0639	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YR821_0640	COG0617	tRNA 3'-terminal CCA addition
YR821_0643	COG1489	DNA binding
YR821_0644	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
YR821_0645	COG1643	Atp-dependent helicase
YR821_0646	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YR821_0647	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
YR821_0649	COG0316	Belongs to the HesB IscA family
YR821_0650	COG2860	membrane
YR821_0652	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YR821_0653	COG0232	Belongs to the dGTPase family. Type 2 subfamily
YR821_0654	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YR821_0656	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YR821_0657	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YR821_0658	COG3956	TIGRFAM MazG family protein
YR821_0659	COG0504	CTP synthase activity
YR821_0662	COG0602	queuosine metabolic process
YR821_0663	COG0720	synthase
YR821_0664	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
YR821_0666	COG0175	sulfate reduction
YR821_0669	COG2234	aminopeptidase activity
YR821_0670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
YR821_0670	COG1648	precorrin-2 dehydrogenase activity
YR821_0671	COG0175	sulfate reduction
YR821_0672	COG2895	sulfate adenylyltransferase (ATP) activity
YR821_0673	COG0529	Catalyzes the synthesis of activated sulfate
YR821_0676	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
YR821_0678	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
YR821_0679	COG0585	pseudouridine synthase activity
YR821_0680	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
YR821_0683	COG4942	peptidase
YR821_0683	COG1388	LysM domain
YR821_0684	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YR821_0685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
YR821_0688	COG2801	Transposase and inactivated derivatives
YR821_0689	COG2963	transposase activity
YR821_0700	COG0784	Response regulator, receiver
YR821_0700	COG2205	protein histidine kinase activity
YR821_0704	COG0741	lytic transglycosylase activity
YR821_0732	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YR821_0736	COG2963	transposase activity
YR821_0739	COG3397	chitin binding
YR821_0741	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
YR821_0750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YR821_0752	COG3031	protein transport across the cell outer membrane
YR821_0757	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
YR821_0757	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
YR821_0760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
YR821_0761	COG2137	regulation of response to DNA damage stimulus
YR821_0762	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YR821_0763	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
YR821_0764	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YR821_0765	COG1238	metal cluster binding
YR821_0766	COG2918	glutathione biosynthetic process
YR821_0767	COG1854	S-ribosylhomocysteine lyase activity
YR821_0768	COG4536	flavin adenine dinucleotide binding
YR821_0769	COG4137	Cytochrome C assembly protein
YR821_0770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YR821_0772	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
YR821_0773	COG0336	Belongs to the RNA methyltransferase TrmD family
YR821_0774	COG0335	large ribosomal subunit rRNA binding
YR821_0775	COG3137	Salt-induced outer membrane protein
YR821_0776	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YR821_0778	COG3279	Response regulator of the LytR AlgR family
YR821_0779	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YR821_0780	COG0287	Prephenate dehydrogenase
YR821_0780	COG1605	Chorismate mutase
YR821_0781	COG0077	Prephenate dehydratase
YR821_0781	COG1605	Chorismate mutase
YR821_0782	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
YR821_0783	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YR821_0784	COG0564	pseudouridine synthase activity
YR821_0785	COG1496	oxidoreductase activity
YR821_0786	COG0542	response to heat
YR821_0787	COG3021	interspecies interaction between organisms
YR821_0788	COG1388	LysM domain
YR821_0788	COG0741	lytic transglycosylase activity
YR821_0790	COG2226	methyltransferase
YR821_0792	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YR821_0793	COG1960	acyl-CoA dehydrogenase activity
YR821_0794	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
YR821_0795	COG0121	glutamine amidotransferase
YR821_0796	COG3034	peptidoglycan biosynthetic process
YR821_0799	COG1805	sodium ion transport
YR821_0800	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YR821_0801	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YR821_0802	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YR821_0804	COG1477	protein flavinylation
YR821_0805	COG2991	Protein conserved in bacteria
YR821_0807	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
YR821_0808	COG2195	Cleaves the N-terminal amino acid of tripeptides
YR821_0809	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
YR821_0810	COG1073	alpha beta
YR821_0813	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
YR821_0820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
YR821_0825	COG4126	flavin adenine dinucleotide binding
YR821_0828	COG2974	May be involved in recombination
YR821_0829	COG1940	carbohydrate kinase activity
YR821_0830	COG0419	ATPase involved in DNA repair
YR821_0831	COG0420	3'-5' exonuclease activity
YR821_0833	COG0745	RESPONSE REGULATOR receiver
YR821_0834	COG5002	protein histidine kinase activity
YR821_0838	COG1113	amino acid transport
YR821_0839	COG0366	Alpha amylase catalytic
YR821_0840	COG0300	oxidoreductase activity
YR821_0841	COG0450	alkyl hydroperoxide reductase
YR821_0842	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
YR821_0845	COG1862	Preprotein translocase
YR821_0846	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YR821_0847	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YR821_0848	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
YR821_0849	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YR821_0849	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YR821_0850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
YR821_0852	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
YR821_0853	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
YR821_0854	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
YR821_0855	COG0142	geranyltranstransferase activity
YR821_0862	COG0693	protein deglycase activity
YR821_0863	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
YR821_0864	COG1666	GTP binding
YR821_0865	COG2814	Major facilitator Superfamily
YR821_0867	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
YR821_0868	COG1845	cytochrome c oxidase, subunit III
YR821_0869	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YR821_0870	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YR821_0872	COG2223	nitrite transmembrane transporter activity
YR821_0873	COG3056	Lipoprotein
YR821_0874	COG0271	Belongs to the BolA IbaG family
YR821_0878	COG0740	serine-type endopeptidase activity
YR821_0879	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
YR821_0880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YR821_0881	COG0776	regulation of translation
YR821_0882	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YR821_0883	COG1555	photosystem II stabilization
YR821_0884	COG0824	Thioesterase
YR821_0885	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
YR821_0886	COG4533	DNA binding
YR821_0889	COG1522	sequence-specific DNA binding
YR821_0890	COG1132	(ABC) transporter
YR821_0891	COG1132	(ABC) transporter
YR821_0892	COG0347	Belongs to the P(II) protein family
YR821_0893	COG0004	ammonium transporteR
YR821_0894	COG1946	Acyl-CoA thioesterase
YR821_0895	COG3695	enzyme binding
YR821_0901	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YR821_0902	COG0254	rRNA binding
YR821_0903	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YR821_0904	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YR821_0905	COG1309	transcriptional regulator
YR821_0906	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
YR821_0907	COG1196	nuclear chromosome segregation
YR821_0907	COG3264	Mechanosensitive ion channel
YR821_0910	COG2832	Protein of unknown function (DUF454)
YR821_0911	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YR821_0919	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
YR821_0920	COG0326	Molecular chaperone. Has ATPase activity
YR821_0923	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YR821_0924	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YR821_0925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YR821_0926	COG4651	solute:proton antiporter activity
YR821_0926	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YR821_0929	COG0737	Belongs to the 5'-nucleotidase family
YR821_0930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YR821_0931	COG3735	TraB family
YR821_0932	COG2217	Heavy metal translocating P-type atpase
YR821_0933	COG0789	Transcriptional regulator
YR821_0934	COG1585	Membrane protein implicated in regulation of membrane protease activity
YR821_0935	COG0330	HflC and HflK could
YR821_0936	COG3118	belongs to the thioredoxin family
YR821_0937	COG0300	oxidoreductase activity
YR821_0938	COG2755	lipolytic protein G-D-S-L family
YR821_0939	COG4181	ATPase activity
YR821_0940	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
YR821_0941	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
YR821_0942	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
YR821_0944	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YR821_0945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YR821_0951	COG3188	usher protein
YR821_0952	COG3121	Chaperone
YR821_0958	COG2501	S4 domain
YR821_0959	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
YR821_0960	COG0582	viral genome integration into host DNA
YR821_0963	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
YR821_0964	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
YR821_0966	COG2963	transposase activity
YR821_0968	COG0732	type I restriction modification DNA specificity domain
YR821_0969	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
YR821_0975	COG3596	GTP binding
YR821_0981	COG2003	Belongs to the UPF0758 family
YR821_0989	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YR821_0990	COG1393	Belongs to the ArsC family
YR821_0992	COG1022	Amp-dependent synthetase and ligase
YR821_0997	COG3038	cytochrome b561
YR821_1003	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
YR821_1005	COG1215	transferase activity, transferring glycosyl groups
YR821_1009	COG3250	beta-galactosidase activity
YR821_1012	COG1309	transcriptional regulator
YR821_1019	COG2197	response regulator
YR821_1020	COG1278	Cold shock
YR821_1024	COG3706	GGDEF domain
YR821_1026	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
YR821_1028	COG2921	Belongs to the UPF0250 family
YR821_1029	COG1686	Belongs to the peptidase S11 family
YR821_1030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YR821_1031	COG0772	Belongs to the SEDS family
YR821_1032	COG0768	penicillin binding
YR821_1033	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
YR821_1034	COG0799	negative regulation of ribosome biogenesis
YR821_1035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
YR821_1036	COG1466	dna polymerase III delta subunit
YR821_1037	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
YR821_1040	COG2888	peptidyl-tyrosine sulfation
YR821_1041	COG1126	abc transporter atp-binding protein
YR821_1042	COG0765	amino acid transport
YR821_1043	COG0765	amino acid transport
YR821_1046	COG0815	Transfers the fatty acyl group on membrane lipoproteins
YR821_1047	COG4535	Mg2 and Co2 transporter CorC
YR821_1048	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
YR821_1049	COG1702	phosphate starvation-inducible protein PhoH
YR821_1051	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YR821_1052	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YR821_1053	COG0367	asparagine synthase
YR821_1054	COG0647	UMP catabolic process
YR821_1055	COG1940	carbohydrate kinase activity
YR821_1055	COG1846	Transcriptional regulator
YR821_1056	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
YR821_1059	COG1263	PTS System
YR821_1059	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YR821_1059	COG2190	(PTS) system
YR821_1064	COG0735	belongs to the Fur family
YR821_1066	COG0840	transmembrane signaling receptor activity
YR821_1069	COG0596	Alpha beta hydrolase
YR821_1070	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
YR821_1071	COG0033	Phosphoglucomutase
YR821_1073	COG0745	RESPONSE REGULATOR receiver
YR821_1074	COG2205	protein histidine kinase activity
YR821_1075	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
YR821_1076	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
YR821_1079	COG3272	Protein of unknown function (DUF1722)
YR821_1080	COG0415	Belongs to the DNA photolyase family
YR821_1081	COG5212	phosphodiesterase
YR821_1082	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
YR821_1083	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
YR821_1084	COG1984	allophanate hydrolase subunit 2
YR821_1085	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
YR821_1092	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
YR821_1093	COG1053	succinate dehydrogenase
YR821_1094	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
YR821_1095	COG0567	Dehydrogenase, E1 component
YR821_1096	COG0508	dehydrogenase complex catalyzes the overall conversion of
YR821_1097	COG0045	succinate-CoA ligase (ADP-forming) activity
YR821_1098	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
YR821_1099	COG0737	Belongs to the 5'-nucleotidase family
YR821_1100	COG1271	oxidase subunit
YR821_1101	COG1294	oxidase, subunit
YR821_1102	COG4890	Cyd operon protein YbgT
YR821_1103	COG3790	cyd operon protein YbgE
YR821_1104	COG0824	Thioesterase
YR821_1105	COG0811	peptide transport
YR821_1106	COG0848	biopolymer transport protein
YR821_1107	COG3064	Membrane
YR821_1107	COG3064	Membrane
YR821_1108	COG0823	Involved in the tonB-independent uptake of proteins
YR821_1109	COG2885	chlorophyll binding
YR821_1110	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
YR821_1112	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
YR821_1114	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YR821_1114	COG2205	protein histidine kinase activity
YR821_1116	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YR821_1117	COG0588	phosphoglycerate mutase activity
YR821_1119	COG2017	converts alpha-aldose to the beta-anomer
YR821_1121	COG1085	galactose-1-phosphate uridylyltransferase
YR821_1122	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YR821_1124	COG2005	Transcriptional regulator
YR821_1124	COG3585	molybdate ion transport
YR821_1126	COG0725	ABC transporter, periplasmic molybdate-binding protein
YR821_1127	COG4149	molybdate abc transporter
YR821_1129	COG0561	phosphatase activity
YR821_1130	COG2706	6-phosphogluconolactonase activity
YR821_1133	COG0156	8-amino-7-oxononanoate synthase activity
YR821_1134	COG2226	methyltransferase
YR821_1137	COG0556	nucleotide-excision repair
YR821_1138	COG4628	conserved protein (DUF2132)
YR821_1141	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YR821_1142	COG1120	ATPase activity
YR821_1143	COG0391	Required for morphogenesis under gluconeogenic growth conditions
YR821_1145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YR821_1147	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
YR821_1148	COG0314	molybdopterin synthase activity
YR821_1149	COG0670	Belongs to the BI1 family
YR821_1150	COG0842	Transport permease protein
YR821_1151	COG0842	Transport permease protein
YR821_1152	COG1131	(ABC) transporter
YR821_1153	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YR821_1154	COG1309	transcriptional regulator
YR821_1155	COG0513	Belongs to the DEAD box helicase family
YR821_1156	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YR821_1158	COG1686	Belongs to the peptidase S11 family
YR821_1160	COG0277	FAD linked oxidase domain protein
YR821_1164	COG2261	transglycosylase associated protein
YR821_1166	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
YR821_1168	COG3639	organic phosphonate transmembrane transporter activity
YR821_1169	COG4807	Protein conserved in bacteria
YR821_1171	COG2897	thiosulfate sulfurtransferase activity
YR821_1172	COG1732	Glycine betaine
YR821_1173	COG1174	glycine betaine transport
YR821_1174	COG1125	glycine betaine transport
YR821_1175	COG1174	glycine betaine transport
YR821_1176	COG0531	amino acid
YR821_1177	COG1982	Orn Lys Arg decarboxylase major
YR821_1179	COG0697	spore germination
YR821_1182	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YR821_1183	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
YR821_1184	COG1126	abc transporter atp-binding protein
YR821_1185	COG0765	amino acid transport
YR821_1186	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YR821_1189	COG5006	permease, DMT superfamily
YR821_1190	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
YR821_1191	COG2239	Acts as a magnesium transporter
YR821_1193	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
YR821_1194	COG0488	(ABC) transporter
YR821_1195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YR821_1196	COG0303	'Molybdopterin
YR821_1200	COG0583	DNA-binding transcription factor activity
YR821_1201	COG0477	Major facilitator Superfamily
YR821_1202	COG0302	gtp cyclohydrolase
YR821_1203	COG2311	Membrane
YR821_1209	COG2949	membrane
YR821_1210	COG0281	malic enzyme
YR821_1212	COG0583	DNA-binding transcription factor activity
YR821_1214	COG1346	cytolysis
YR821_1215	COG1380	Effector of murein hydrolase LrgA
YR821_1218	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YR821_1218	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YR821_1219	COG0489	protein tyrosine kinase activity
YR821_1220	COG0572	uridine kinase
YR821_1221	COG0717	Belongs to the dCTP deaminase family
YR821_1222	COG2982	Protein involved in outer membrane biogenesis
YR821_1223	COG3069	C4-dicarboxylate transmembrane transporter activity
YR821_1224	COG1253	flavin adenine dinucleotide binding
YR821_1225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YR821_1226	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YR821_1228	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
YR821_1229	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YR821_1229	COG0140	phosphoribosyl-ATP diphosphatase activity
YR821_1231	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
YR821_1233	COG0131	Imidazoleglycerol-phosphate dehydratase
YR821_1233	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YR821_1234	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YR821_1235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
YR821_1238	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YR821_1239	COG0625	glutathione transferase activity
YR821_1245	COG0626	cystathionine gamma-synthase activity
YR821_1247	COG1686	Belongs to the peptidase S11 family
YR821_1248	COG1760	l-serine dehydratase
YR821_1249	COG0814	amino acid
YR821_1250	COG1349	DNA-binding transcription factor activity
YR821_1252	COG0671	phosphoesterase, PA-phosphatase related
YR821_1264	COG2985	domain, Protein
YR821_1264	COG0569	domain protein
YR821_1270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
YR821_1271	COG3842	ATPase activity
YR821_1272	COG1176	ABC-type spermidine putrescine transport system, permease component I
YR821_1276	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YR821_1278	COG4160	amino acid transport
YR821_1279	COG4215	(ABC) transporter
YR821_1280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YR821_1281	COG1126	abc transporter atp-binding protein
YR821_1283	COG0393	Putative heavy-metal-binding
YR821_1284	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YR821_1285	COG0702	epimerase
YR821_1286	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
YR821_1288	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YR821_1289	COG1151	hydroxylamine reductase activity
YR821_1290	COG2431	L-lysine efflux transmembrane transporter activity
YR821_1291	COG3593	DNA synthesis involved in DNA repair
YR821_1292	COG2990	Protein conserved in bacteria
YR821_1293	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YR821_1295	COG1278	Cold shock
YR821_1296	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
YR821_1297	COG0542	response to heat
YR821_1298	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
YR821_1300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
YR821_1302	COG0492	ferredoxin-NADP+ reductase activity
YR821_1304	COG1522	sequence-specific DNA binding
YR821_1305	COG1674	ftsk spoiiie
YR821_1305	COG3107	peptidoglycan biosynthetic process
YR821_1306	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
YR821_1307	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YR821_1308	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
YR821_1309	COG2814	Major facilitator Superfamily
YR821_1310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
YR821_1311	COG1882	Formate acetyltransferase
YR821_1312	COG2116	formate transmembrane transporter activity
YR821_1313	COG1944	ATP diphosphatase activity
YR821_1314	COG0252	asparaginase activity
YR821_1316	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
YR821_1318	COG0539	negative regulation of cytoplasmic translation
YR821_1320	COG0658	competence protein
YR821_1320	COG2333	competence protein COMEC
YR821_1322	COG1663	tetraacyldisaccharide 4'-kinase activity
YR821_1323	COG5383	Protein conserved in bacteria
YR821_1325	COG1278	Cold shock
YR821_1326	COG2835	tetraacyldisaccharide 4'-kinase activity
YR821_1327	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
YR821_1328	COG3173	Aminoglycoside phosphotransferase
YR821_1329	COG1434	Gram-negative-bacterium-type cell wall biogenesis
YR821_1330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YR821_1331	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
YR821_1333	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
YR821_1334	COG2989	Protein conserved in bacteria
YR821_1335	COG3108	Peptidase M15
YR821_1336	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YR821_1337	COG1448	Aminotransferase
YR821_1340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
YR821_1341	COG0308	aminopeptidase N
YR821_1342	COG0167	dihydroorotate dehydrogenase activity
YR821_1345	COG0116	Belongs to the methyltransferase superfamily
YR821_1345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
YR821_1346	COG0488	(ABC) transporter
YR821_1347	COG2995	paraquat-inducible protein a
YR821_1348	COG3008	intermembrane lipid transfer
YR821_1348	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YR821_1349	COG3009	Protein conserved in bacteria
YR821_1350	COG3130	regulation of translation
YR821_1351	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YR821_1352	COG1067	ATP-dependent peptidase activity
YR821_1353	COG3120	sequence-specific DNA binding
YR821_1355	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
YR821_1356	COG3070	regulator of competence-specific genes
YR821_1357	COG1289	transmembrane transporter activity
YR821_1358	COG3304	Inner membrane component domain
YR821_1359	COG0210	DNA helicase
YR821_1360	COG1803	Methylglyoxal synthase
YR821_1362	COG1832	CoA-binding protein
YR821_1363	COG3785	DNA binding
YR821_1364	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
YR821_1365	COG1254	Belongs to the acylphosphatase family
YR821_1366	COG2920	part of a sulfur-relay system
YR821_1368	COG0288	reversible hydration of carbon dioxide
YR821_1373	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
YR821_1374	COG2943	transferase activity, transferring hexosyl groups
YR821_1378	COG1560	Kdo2-lipid A biosynthetic process
YR821_1381	COG0628	permease
YR821_1386	COG0418	dihydroorotase activity
YR821_1387	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
YR821_1389	COG1530	ribonuclease E activity
YR821_1391	COG0564	pseudouridine synthase activity
YR821_1392	COG0424	maF-like protein
YR821_1393	COG1399	metal-binding, possibly nucleic acid-binding protein
YR821_1394	COG0333	Belongs to the bacterial ribosomal protein bL32 family
YR821_1396	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YR821_1397	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YR821_1399	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YR821_1400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YR821_1401	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YR821_1402	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YR821_1403	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
YR821_1404	COG0470	DNA polymerase III
YR821_1405	COG0084	hydrolase, TatD family'
YR821_1406	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YR821_1406	COG1263	PTS System
YR821_1408	COG0537	adenosine 5'-monophosphoramidase activity
YR821_1409	COG5633	Lipoprotein
YR821_1410	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
YR821_1413	COG3150	esterase
YR821_1414	COG1252	NADH dehydrogenase
YR821_1415	COG3134	Outer membrane lipoprotein
YR821_1416	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
YR821_1417	COG4591	ABC-type transport system involved in lipoprotein release permease component
YR821_1419	COG4591	ABC-type transport system involved in lipoprotein release permease component
YR821_1423	COG2850	peptidyl-arginine hydroxylation
YR821_1424	COG2205	protein histidine kinase activity
YR821_1425	COG0745	RESPONSE REGULATOR receiver
YR821_1427	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YR821_1428	COG2915	High frequency lysogenization protein hflD homolog
YR821_1429	COG0482	sulfurtransferase activity
YR821_1432	COG1187	pseudouridine synthase activity
YR821_1433	COG0538	isocitrate dehydrogenase activity
YR821_1434	COG2771	luxR family
YR821_1435	COG3916	Acyl-homoserine-lactone synthase
YR821_1437	COG2723	6-phospho-beta-galactosidase activity
YR821_1439	COG0339	signal peptide processing
YR821_1440	COG0840	transmembrane signaling receptor activity
YR821_1442	COG3493	citrate carrier protein
YR821_1443	COG4565	transcriptional regulatory protein
YR821_1444	COG3290	protein histidine kinase activity
YR821_1445	COG0471	metal ion transport
YR821_1455	COG4977	sequence-specific DNA binding
YR821_1457	COG1702	phosphate starvation-inducible protein PhoH
YR821_1458	COG0387	Pfam Sodium calcium exchanger
YR821_1459	COG2375	cellular response to nickel ion
YR821_1460	COG3850	Histidine kinase
YR821_1462	COG1294	oxidase, subunit
YR821_1463	COG1271	oxidase subunit
YR821_1465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YR821_1466	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
YR821_1467	COG3138	arginine N-succinyltransferase
YR821_1469	COG3724	N-succinylarginine dihydrolase activity
YR821_1473	COG1228	amidohydrolase
YR821_1475	COG0402	S-adenosylhomocysteine deaminase activity
YR821_1479	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
YR821_1480	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
YR821_1481	COG3383	formate dehydrogenase (NAD+) activity
YR821_1482	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YR821_1483	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
YR821_1485	COG3260	NADH ubiquinone oxidoreductase 20
YR821_1486	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YR821_1487	COG3261	NADH dehydrogenase
YR821_1487	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
YR821_1488	COG0650	Formate hydrogenlyase subunit 4
YR821_1490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YR821_1492	COG0375	protein maturation
YR821_1493	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
YR821_1494	COG0298	carbon dioxide binding
YR821_1495	COG0409	Hydrogenase expression formation protein
YR821_1496	COG0309	Hydrogenase expression formation protein (HypE)
YR821_1497	COG2963	transposase activity
YR821_1506	COG2207	Transcriptional regulator
YR821_1506	COG3708	Transcriptional regulator
YR821_1507	COG0012	GTP binding
YR821_1509	COG0193	aminoacyl-tRNA hydrolase activity
YR821_1512	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YR821_1514	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
YR821_1516	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
YR821_1517	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
YR821_1518	COG2890	protein-(glutamine-N5) methyltransferase activity
YR821_1521	COG2877	3-deoxy-8-phosphooctulonate synthase activity
YR821_1522	COG0659	secondary active sulfate transmembrane transporter activity
YR821_1523	COG3706	GGDEF domain
YR821_1526	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YR821_1528	COG3381	protein complex oligomerization
YR821_1533	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YR821_1536	COG0728	peptidoglycan biosynthetic process
YR821_1542	COG3102	Protein conserved in bacteria
YR821_1543	COG3142	Participates in the control of copper homeostasis
YR821_1546	COG3788	relative of glutathione S-transferase, MAPEG superfamily
YR821_1548	COG1801	Protein of unknown function DUF72
YR821_1550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
YR821_1551	COG0494	nUDIX hydrolase
YR821_1553	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
YR821_1555	COG2255	four-way junction helicase activity
YR821_1556	COG3104	oligopeptide transport
YR821_1557	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YR821_1558	COG1121	(ABC) transporter
YR821_1559	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
YR821_1560	COG0739	heme binding
YR821_1561	COG1560	Kdo2-lipid A biosynthetic process
YR821_1562	COG0469	pyruvate kinase activity
YR821_1563	COG1737	Transcriptional regulator
YR821_1564	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YR821_1565	COG0800	Aldolase
YR821_1567	COG2076	Multidrug Resistance protein
YR821_1568	COG0251	oxidation-reduction process
YR821_1569	COG1199	ATP-dependent helicase activity
YR821_1570	COG1214	PFAM Peptidase M22, glycoprotease
YR821_1571	COG3065	identical protein binding
YR821_1573	COG0318	PFAM AMP-dependent synthetase and ligase
YR821_1574	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
YR821_1575	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
YR821_1576	COG2894	cell division
YR821_1577	COG0850	regulation of cytokinetic process
YR821_1579	COG3100	YcgL domain-containing protein
YR821_1580	COG0179	Fumarylacetoacetate (FAA) hydrolase
YR821_1581	COG2983	Belongs to the UPF0260 family
YR821_1586	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YR821_1588	COG2719	SpoVR family
YR821_1589	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YR821_1590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YR821_1591	COG2814	Major facilitator Superfamily
YR821_1593	COG2200	EAL domain
YR821_1593	COG2202	Pas domain
YR821_1593	COG2199	diguanylate cyclase activity
YR821_1597	COG2718	Belongs to the UPF0229 family
YR821_1598	COG2766	serine protein kinase
YR821_1600	COG3713	MltA-interacting MipA family protein
YR821_1601	COG2194	sulfuric ester hydrolase activity
YR821_1604	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YR821_1605	COG3139	Protein of unknown function (DUF1315)
YR821_1606	COG1335	isochorismatase
YR821_1607	COG0252	asparaginase activity
YR821_1608	COG0616	signal peptide processing
YR821_1609	COG0778	Nitroreductase
YR821_1611	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YR821_1613	COG0494	nUDIX hydrolase
YR821_1614	COG0708	Exodeoxyribonuclease III
YR821_1619	COG0788	formyltetrahydrofolate deformylase activity
YR821_1620	COG3012	SEC-C Motif Domain Protein
YR821_1621	COG2963	transposase activity
YR821_1623	COG1752	Esterase of the alpha-beta hydrolase superfamily
YR821_1624	COG0745	RESPONSE REGULATOR receiver
YR821_1630	COG1454	alcohol dehydrogenase
YR821_1630	COG1012	belongs to the aldehyde dehydrogenase family
YR821_1632	COG2095	MarC family integral membrane protein
YR821_1633	COG4166	transmembrane transport
YR821_1636	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YR821_1639	COG3099	Belongs to the UPF0263 family
YR821_1640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YR821_1646	COG2350	Protein conserved in bacteria
YR821_1649	COG3710	Transcriptional regulator
YR821_1656	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
YR821_1661	COG0727	PFAM Uncharacterised protein family (UPF0153)
YR821_1662	COG3047	cAMP biosynthetic process
YR821_1665	COG0133	tryptophan synthase activity
YR821_1666	COG0135	phosphoribosylanthranilate isomerase activity
YR821_1666	COG0134	indole-3-glycerol-phosphate synthase activity
YR821_1668	COG0512	Glutamine amidotransferase of anthranilate synthase
YR821_1670	COG0613	PHP domain protein
YR821_1671	COG0009	L-threonylcarbamoyladenylate synthase
YR821_1672	COG1187	pseudouridine synthase activity
YR821_1674	COG1028	Short-chain dehydrogenase reductase Sdr
YR821_1675	COG1028	Short-chain dehydrogenase reductase Sdr
YR821_1676	COG0616	signal peptide processing
YR821_1679	COG0583	DNA-binding transcription factor activity
YR821_1683	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
YR821_1685	COG0671	phosphoesterase, PA-phosphatase related
YR821_1686	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
YR821_1687	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
YR821_1692	COG0023	Translation Initiation Factor
YR821_1694	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YR821_1695	COG5002	protein histidine kinase activity
YR821_1695	COG5001	Diguanylate cyclase
YR821_1695	COG3447	MASE1 domain protein
YR821_1696	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
YR821_1697	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YR821_1699	COG4659	FMN binding
YR821_1701	COG2207	Transcriptional regulator
YR821_1701	COG3708	Transcriptional regulator
YR821_1704	COG4657	Part of a membrane complex involved in electron transport
YR821_1706	COG2759	Belongs to the formate--tetrahydrofolate ligase family
YR821_1708	COG0673	inositol 2-dehydrogenase activity
YR821_1709	COG0385	Bile acid
YR821_1710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
YR821_1711	COG5339	Protein conserved in bacteria
YR821_1712	COG1482	cell wall glycoprotein biosynthetic process
YR821_1714	COG0114	fumarate hydratase activity
YR821_1721	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YR821_1726	COG1742	UPF0060 membrane protein
YR821_1727	COG4221	oxidoreductase activity
YR821_1728	COG3023	N-Acetylmuramoyl-L-alanine amidase
YR821_1733	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YR821_1739	COG2015	COG2015, Alkyl sulfatase and related hydrolases
YR821_1743	COG1011	Hydrolase
YR821_1747	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
YR821_1749	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YR821_1750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YR821_1751	COG0589	response to stress
YR821_1757	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
YR821_1758	COG3623	hexulose-6-phosphate isomerase
YR821_1759	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
YR821_1760	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
YR821_1762	COG0531	amino acid
YR821_1764	COG0745	RESPONSE REGULATOR receiver
YR821_1765	COG2205	protein histidine kinase activity
YR821_1769	COG2207	Transcriptional regulator
YR821_1770	COG1881	PFAM PEBP family protein
YR821_1773	COG3591	Belongs to the peptidase S1B family
YR821_1774	COG1643	Atp-dependent helicase
YR821_1775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
YR821_1776	COG3784	Protein of unknown function (DUF1318)
YR821_1779	COG2911	Protein conserved in bacteria
YR821_1780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YR821_1781	COG3187	Heat shock protein
YR821_1782	COG3042	response to heat
YR821_1783	COG1285	pathogenesis
YR821_1785	COG0674	pyruvate-flavodoxin oxidoreductase activity
YR821_1785	COG1013	pyruvate-flavodoxin oxidoreductase activity
YR821_1785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YR821_1785	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YR821_1788	COG4166	transmembrane transport
YR821_1789	COG2866	Carboxypeptidase
YR821_1790	COG4948	Mandelate Racemase Muconate Lactonizing
YR821_1791	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
YR821_1793	COG5642	Protein of unknown function (DUF2384)
YR821_1794	COG5654	RES domain protein
YR821_1795	COG3768	UPF0283 membrane protein
YR821_1796	COG3106	COG3106 Predicted ATPase
YR821_1798	COG1983	PspC domain protein
YR821_1800	COG1842	Phage shock protein A
YR821_1805	COG4166	transmembrane transport
YR821_1807	COG4171	peptide transport system, permease
YR821_1808	COG4172	Belongs to the ABC transporter superfamily
YR821_1809	COG4172	Belongs to the ABC transporter superfamily
YR821_1811	COG3104	oligopeptide transport
YR821_1814	COG0484	heat shock protein binding
YR821_1823	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
YR821_1824	COG3133	Outer membrane lipoprotein
YR821_1825	COG1846	Transcriptional regulator
YR821_1828	COG4989	oxidoreductase activity
YR821_1829	COG3313	Fe-S protein
YR821_1830	COG2194	sulfuric ester hydrolase activity
YR821_1831	COG1309	transcriptional regulator
YR821_1832	COG1902	pentaerythritol trinitrate reductase activity
YR821_1836	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
YR821_1838	COG0791	NLP P60 protein
YR821_1839	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YR821_1840	COG1609	Transcriptional regulator
YR821_1841	COG0583	DNA-binding transcription factor activity
YR821_1842	COG2814	Major facilitator Superfamily
YR821_1843	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YR821_1844	COG0307	riboflavin synthase, alpha
YR821_1849	COG1376	ErfK ybiS ycfS ynhG family protein
YR821_1849	COG1388	LysM domain
YR821_1850	COG2166	iron-sulfur cluster assembly
YR821_1852	COG0719	Fe-S assembly protein
YR821_1853	COG0396	ATPase activity
YR821_1854	COG0719	Fe-S assembly protein
YR821_1855	COG0316	Belongs to the HesB IscA family
YR821_1857	COG2050	protein possibly involved in aromatic compounds catabolism
YR821_1858	COG0277	FAD linked oxidase domain protein
YR821_1858	COG0247	lactate metabolic process
YR821_1859	COG0628	permease
YR821_1860	COG0574	Belongs to the PEP-utilizing enzyme family
YR821_1860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YR821_1862	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
YR821_1863	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YR821_1865	COG4771	TonB-dependent receptor
YR821_1866	COG3720	iron ion transport
YR821_1867	COG4558	Periplasmic binding protein
YR821_1868	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YR821_1869	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YR821_1871	COG0095	Lipoate-protein ligase
YR821_1872	COG0791	NLP P60 protein
YR821_1873	COG2076	Multidrug Resistance protein
YR821_1874	COG2076	Multidrug Resistance protein
YR821_1875	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
YR821_1878	COG0463	Glycosyl transferase, family 2
YR821_1879	COG1215	transferase activity, transferring glycosyl groups
YR821_1880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YR821_1882	COG4139	cobalamin transport
YR821_1883	COG4974	Belongs to the 'phage' integrase family
YR821_1886	COG2184	nucleotidyltransferase activity
YR821_1887	COG2184	nucleotidyltransferase activity
YR821_1892	COG0776	regulation of translation
YR821_1909	COG0803	Belongs to the bacterial solute-binding protein 9 family
YR821_1910	COG1121	(ABC) transporter
YR821_1911	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YR821_1912	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YR821_1913	COG3001	Fructosamine kinase
YR821_1915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YR821_1916	COG1988	membrane-bound metal-dependent
YR821_1917	COG1823	symporter activity
YR821_1918	COG3023	N-Acetylmuramoyl-L-alanine amidase
YR821_1920	COG2814	Major facilitator Superfamily
YR821_1921	COG0501	Belongs to the peptidase M48B family
YR821_1922	COG0793	Belongs to the peptidase S41A family
YR821_1924	COG1956	GAF domain-containing protein
YR821_1925	COG2995	paraquat-inducible protein a
YR821_1926	COG3008	intermembrane lipid transfer
YR821_1927	COG2203	Gaf domain
YR821_1927	COG4251	negative regulation of phosphorylation
YR821_1927	COG3706	GGDEF domain
YR821_1927	COG5001	Diguanylate cyclase
YR821_1943	COG1276	copper resistance
YR821_1944	COG2372	response to copper ion
YR821_1945	COG1528	Iron-storage protein
YR821_1951	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YR821_1952	COG1770	oligopeptidase
YR821_1955	COG3097	Belongs to the UPF0267 family
YR821_1956	COG3141	response to X-ray
YR821_1957	COG0513	Belongs to the DEAD box helicase family
YR821_1961	COG0494	nUDIX hydrolase
YR821_1962	COG1760	l-serine dehydratase
YR821_1964	COG1253	flavin adenine dinucleotide binding
YR821_1965	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YR821_1965	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YR821_1966	COG3715	PTS system
YR821_1967	COG3716	PTS system mannose fructose sorbose family IID component
YR821_1968	COG4811	Protein of unknown function (DUF986)
YR821_1969	COG1971	Probably functions as a manganese efflux pump
YR821_1973	COG1960	acyl-CoA dehydrogenase activity
YR821_1975	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
YR821_1981	COG2226	methyltransferase
YR821_1982	COG0768	penicillin binding
YR821_1983	COG1496	oxidoreductase activity
YR821_1988	COG1113	amino acid transport
YR821_1997	COG2207	Transcriptional regulator
YR821_2001	COG1132	(ABC) transporter
YR821_2003	COG4251	negative regulation of phosphorylation
YR821_2003	COG5001	Diguanylate cyclase
YR821_2003	COG3706	GGDEF domain
YR821_2003	COG2203	Gaf domain
YR821_2007	COG1181	Belongs to the D-alanine--D-alanine ligase family
YR821_2012	COG1278	Cold shock
YR821_2013	COG1278	Cold shock
YR821_2018	COG1917	Cupin 2, conserved barrel domain protein
YR821_2018	COG2169	Transcriptional regulator
YR821_2019	COG1447	Phosphotransferase system cellobiose-specific component IIA
YR821_2020	COG2723	6-phospho-beta-galactosidase activity
YR821_2021	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YR821_2022	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YR821_2024	COG1187	pseudouridine synthase activity
YR821_2027	COG3122	Protein conserved in bacteria
YR821_2028	COG1757	Na H antiporter
YR821_2031	COG2235	arginine
YR821_2034	COG0076	glutamate decarboxylase activity
YR821_2035	COG0531	amino acid
YR821_2042	COG2153	protein acetylation
YR821_2043	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
YR821_2050	COG0840	transmembrane signaling receptor activity
YR821_2051	COG4974	Belongs to the 'phage' integrase family
YR821_2070	COG2963	transposase activity
YR821_2077	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
YR821_2078	COG5301	cellulose 1,4-beta-cellobiosidase activity
YR821_2083	COG3299	homolog of phage Mu protein gp47
YR821_2093	COG4386	tail sheath protein
YR821_2101	COG0616	signal peptide processing
YR821_2110	COG3179	chitinase
YR821_2136	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
YR821_2137	COG0322	excinuclease ABC activity
YR821_2138	COG2197	response regulator
YR821_2142	COG1113	amino acid transport
YR821_2144	COG0531	amino acid
YR821_2145	COG3710	Transcriptional regulator
YR821_2147	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YR821_2148	COG0506	proline dehydrogenase activity
YR821_2148	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YR821_2148	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YR821_2149	COG1126	abc transporter atp-binding protein
YR821_2150	COG0765	amino acid transport
YR821_2151	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YR821_2152	COG2515	1-aminocyclopropane-1-carboxylate deaminase
YR821_2154	COG1191	sigma factor activity
YR821_2162	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
YR821_2163	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YR821_2166	COG1677	Flagellar hook-basal body complex protein FliE
YR821_2168	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
YR821_2169	COG1317	bacterial-type flagellum organization
YR821_2170	COG1157	protein secretion by the type III secretion system
YR821_2173	COG1580	Controls the rotational direction of flagella during chemotaxis
YR821_2189	COG1558	bacterial-type flagellum-dependent cell motility
YR821_2190	COG1815	bacterial-type flagellum-dependent cell motility
YR821_2192	COG2747	anti-sigma28 factor FlgM
YR821_2193	COG3418	PFAM FlgN family protein
YR821_2196	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YR821_2197	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YR821_2198	COG1404	Belongs to the peptidase S8 family
YR821_2198	COG4935	Belongs to the peptidase S8 family
YR821_2199	COG2197	response regulator
YR821_2203	COG3188	usher protein
YR821_2207	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
YR821_2208	COG0745	RESPONSE REGULATOR receiver
YR821_2210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YR821_2211	COG0840	transmembrane signaling receptor activity
YR821_2212	COG0840	transmembrane signaling receptor activity
YR821_2213	COG0835	chemotaxis
YR821_2214	COG0643	Histidine kinase
YR821_2214	COG2198	Histidine kinase
YR821_2215	COG1360	Flagellar Motor Protein
YR821_2219	COG0589	response to stress
YR821_2221	COG1285	pathogenesis
YR821_2224	COG0840	transmembrane signaling receptor activity
YR821_2228	COG1609	Transcriptional regulator
YR821_2230	COG3321	synthase
YR821_2230	COG0604	alcohol dehydrogenase
YR821_2230	COG1028	Short-chain dehydrogenase reductase Sdr
YR821_2238	COG0471	metal ion transport
YR821_2241	COG3051	citrate lyase alpha subunit
YR821_2242	COG2301	Belongs to the HpcH HpaI aldolase family
YR821_2243	COG3052	prosthetic group binding
YR821_2244	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
YR821_2245	COG3290	protein histidine kinase activity
YR821_2246	COG4565	transcriptional regulatory protein
YR821_2249	COG2271	Major facilitator Superfamily
YR821_2250	COG1840	ABC-type Fe3 transport system, periplasmic component
YR821_2252	COG3842	ATPase activity
YR821_2254	COG0582	viral genome integration into host DNA
YR821_2257	COG3423	Transcriptional regulator
YR821_2264	COG3451	type IV secretory pathway VirB4
YR821_2268	COG3736	Type IV secretory pathway, component VirB8
YR821_2271	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
YR821_2275	COG4227	nucleotidyltransferase activity
YR821_2280	COG2963	transposase activity
YR821_2288	COG1289	transmembrane transporter activity
YR821_2290	COG2925	Exonuclease
YR821_2291	COG0531	amino acid
YR821_2293	COG4771	TonB-dependent receptor
YR821_2295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YR821_2297	COG0833	amino acid
YR821_2298	COG0583	DNA-binding transcription factor activity
YR821_2300	COG2855	membrane
YR821_2301	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
YR821_2302	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YR821_2302	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
YR821_2302	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YR821_2303	COG1105	Belongs to the carbohydrate kinase PfkB family
YR821_2306	COG3005	denitrification pathway
YR821_2307	COG0243	molybdopterin cofactor binding
YR821_2311	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
YR821_2313	COG0246	Mannitol dehydrogenase
YR821_2315	COG0523	cobalamin synthesis protein
YR821_2316	COG0671	phosphoesterase, PA-phosphatase related
YR821_2317	COG0791	NLP P60 protein
YR821_2318	COG2200	EAL domain
YR821_2319	COG4166	transmembrane transport
YR821_2320	COG4174	ABC transporter (Permease)
YR821_2321	COG4239	(ABC) transporter, permease
YR821_2322	COG4172	Belongs to the ABC transporter superfamily
YR821_2324	COG2814	Major facilitator Superfamily
YR821_2325	COG1187	pseudouridine synthase activity
YR821_2326	COG1061	Type III restriction enzyme res subunit
YR821_2330	COG3082	Protein of unknown function (DUF1414)
YR821_2331	COG3083	sulfuric ester hydrolase activity
YR821_2333	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
YR821_2335	COG3646	Phage regulatory protein
YR821_2337	COG0675	Transposase, IS605 OrfB family
YR821_2342	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
YR821_2343	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YR821_2345	COG2223	nitrite transmembrane transporter activity
YR821_2346	COG0642	Histidine kinase
YR821_2346	COG2198	Histidine kinase
YR821_2348	COG0784	Response regulator, receiver
YR821_2348	COG2205	protein histidine kinase activity
YR821_2351	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YR821_2352	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YR821_2354	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YR821_2356	COG4574	serine-type endopeptidase inhibitor activity
YR821_2358	COG2246	polysaccharide biosynthetic process
YR821_2362	COG0814	amino acid
YR821_2367	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
YR821_2368	COG0596	Alpha beta hydrolase
YR821_2369	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
YR821_2370	COG1169	isochorismate synthase
YR821_2371	COG4575	ribosome binding
YR821_2374	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YR821_2375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
YR821_2377	COG0839	Belongs to the complex I subunit 6 family
YR821_2378	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YR821_2379	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
YR821_2380	COG1034	ATP synthesis coupled electron transport
YR821_2384	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YR821_2385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YR821_2386	COG0583	DNA-binding transcription factor activity
YR821_2388	COG0436	Aminotransferase
YR821_2389	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
YR821_2391	COG0471	metal ion transport
YR821_2391	COG0490	domain, Protein
YR821_2393	COG3013	Belongs to the UPF0304 family
YR821_2394	COG3092	negative regulation of chromosome organization
YR821_2396	COG0857	belongs to the CobB CobQ family
YR821_2396	COG0280	phosphate acetyltransferase
YR821_2397	COG1609	Transcriptional regulator
YR821_2400	COG3037	sugar-specific permease SgaT UlaA
YR821_2401	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
YR821_2402	COG0622	Phosphoesterase
YR821_2404	COG0625	glutathione transferase activity
YR821_2405	COG1090	epimerase
YR821_2407	COG4160	amino acid transport
YR821_2408	COG4215	(ABC) transporter
YR821_2411	COG0163	prenyltransferase activity
YR821_2412	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
YR821_2413	COG1286	toxin biosynthetic process
YR821_2414	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
YR821_2415	COG0285	dihydrofolate synthase activity
YR821_2417	COG0586	Pfam SNARE associated Golgi protein
YR821_2419	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YR821_2424	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YR821_2425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YR821_2432	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YR821_2435	COG3101	peptidyl-lysine hydroxylation
YR821_2436	COG0730	response to heat
YR821_2437	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
YR821_2439	COG2890	protein-(glutamine-N5) methyltransferase activity
YR821_2440	COG2840	Smr protein MutS2
YR821_2441	COG2062	phosphohistidine phosphatase, SixA
YR821_2442	COG1024	Enoyl-CoA hydratase
YR821_2442	COG1250	3-hydroxyacyl-CoA dehydrogenase
YR821_2443	COG0183	Belongs to the thiolase family
YR821_2444	COG3691	Protein conserved in bacteria
YR821_2447	COG3088	subunit of a heme lyase
YR821_2447	COG4235	cytochrome complex assembly
YR821_2448	COG3088	subunit of a heme lyase
YR821_2448	COG4235	cytochrome complex assembly
YR821_2449	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YR821_2450	COG1138	Cytochrome C-type biogenesis protein
YR821_2451	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
YR821_2452	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YR821_2453	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YR821_2454	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YR821_2459	COG2824	Alkylphosphonate utilization operon protein PhnA
YR821_2460	COG2951	lytic endotransglycosylase activity
YR821_2461	COG1598	PFAM Uncharacterised protein family UPF0150
YR821_2463	COG3038	cytochrome b561
YR821_2464	COG0436	Aminotransferase
YR821_2466	COG3275	phosphorelay sensor kinase activity
YR821_2467	COG3279	Response regulator of the LytR AlgR family
YR821_2468	COG2223	nitrite transmembrane transporter activity
YR821_2469	COG0837	glucose binding
YR821_2473	COG1914	H( )-stimulated, divalent metal cation uptake system
YR821_2475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YR821_2480	COG3530	Putative quorum-sensing-regulated virulence factor
YR821_2481	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YR821_2483	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
YR821_2486	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YR821_2489	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YR821_2491	COG4208	sulfate ABC transporter
YR821_2492	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
YR821_2493	COG4150	thiosulfate binding
YR821_2495	COG1737	Transcriptional regulator
YR821_2496	COG2731	YhcH YjgK YiaL family protein
YR821_2500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YR821_2501	COG2837	iron assimilation
YR821_2503	COG3111	PFAM Bacterial OB fold (BOF) protein
YR821_2521	COG1671	Belongs to the UPF0178 family
YR821_2522	COG0280	phosphate acetyltransferase
YR821_2522	COG0281	malic enzyme
YR821_2523	COG0494	nUDIX hydrolase
YR821_2524	COG3005	denitrification pathway
YR821_2525	COG3043	anaerobic respiration
YR821_2526	COG0243	molybdopterin cofactor binding
YR821_2527	COG3062	negative regulation of establishment of protein localization
YR821_2528	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YR821_2528	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
YR821_2529	COG2197	response regulator
YR821_2530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YR821_2532	COG1605	Chorismate mutase
YR821_2534	COG1393	Belongs to the ArsC family
YR821_2535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YR821_2536	COG1876	peptidase activity
YR821_2538	COG0400	carboxylic ester hydrolase activity
YR821_2543	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
YR821_2544	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YR821_2545	COG2716	regulation of RNA biosynthetic process
YR821_2546	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YR821_2547	COG0628	permease
YR821_2548	COG4783	chaperone-mediated protein folding
YR821_2549	COG1393	Belongs to the ArsC family
YR821_2550	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
YR821_2551	COG2233	PERMEase
YR821_2552	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
YR821_2553	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
YR821_2554	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
YR821_2555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YR821_2557	COG0581	inorganic phosphate transmembrane transporter activity
YR821_2558	COG0573	inorganic phosphate transmembrane transporter activity
YR821_2559	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
YR821_2562	COG2239	Acts as a magnesium transporter
YR821_2565	COG0443	Heat shock 70 kDa protein
YR821_2567	COG3121	Chaperone
YR821_2570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YR821_2572	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YR821_2573	COG0477	Major facilitator Superfamily
YR821_2574	COG2205	protein histidine kinase activity
YR821_2575	COG0745	RESPONSE REGULATOR receiver
YR821_2576	COG3422	double-strand break repair
YR821_2577	COG0826	peptidase U32
YR821_2578	COG1597	lipid kinase activity
YR821_2581	COG0351	phosphomethylpyrimidine kinase
YR821_2584	COG0518	GMP synthase (glutamine-hydrolyzing) activity
YR821_2584	COG0519	Catalyzes the synthesis of GMP from XMP
YR821_2585	COG0517	IMP dehydrogenase activity
YR821_2585	COG0516	GMP reductase activity
YR821_2586	COG1570	exodeoxyribonuclease VII activity
YR821_2587	COG1645	bacterial-type flagellum-dependent swarming motility
YR821_2589	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YR821_2590	COG2976	Protein conserved in bacteria
YR821_2591	COG0124	histidyl-tRNA synthetase
YR821_2598	COG4953	penicillin-binding protein 1C
YR821_2599	COG2373	Large extracellular alpha-helical protein
YR821_2602	COG2975	iron-sulfur cluster assembly
YR821_2603	COG0633	Ferredoxin
YR821_2604	COG0443	Heat shock 70 kDa protein
YR821_2607	COG0822	iron-sulfur transferase activity
YR821_2609	COG1959	2 iron, 2 sulfur cluster binding
YR821_2610	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
YR821_2612	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
YR821_2613	COG3683	transport system, periplasmic component
YR821_2614	COG3711	transcriptional antiterminator
YR821_2615	COG2814	Major facilitator Superfamily
YR821_2617	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YR821_2617	COG1017	nitric oxide dioxygenase activity
YR821_2618	COG2188	Transcriptional regulator
YR821_2620	COG3457	Alanine racemase
YR821_2621	COG1735	metal-dependent hydrolase with the TIM-barrel fold
YR821_2624	COG0347	Belongs to the P(II) protein family
YR821_2625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YR821_2625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YR821_2626	COG2204	response regulator
YR821_2627	COG3170	Tfp pilus assembly protein FimV
YR821_2628	COG2205	protein histidine kinase activity
YR821_2631	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
YR821_2633	COG0560	Phosphoserine phosphatase
YR821_2634	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YR821_2634	COG1263	PTS System
YR821_2636	COG1737	Transcriptional regulator
YR821_2637	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YR821_2639	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
YR821_2641	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
YR821_2644	COG0481	GTPase activity
YR821_2645	COG3086	response to oxidative stress
YR821_2647	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
YR821_2649	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
YR821_2651	COG0513	Belongs to the DEAD box helicase family
YR821_2654	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
YR821_2656	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
YR821_2657	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YR821_2658	COG0497	DNA recombination
YR821_2659	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YR821_2661	COG2867	negative regulation of translational initiation
YR821_2662	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
YR821_2663	COG0582	viral genome integration into host DNA
YR821_2669	COG2963	transposase activity
YR821_2671	COG1069	ribulokinase activity
YR821_2673	COG1172	Belongs to the binding-protein-dependent transport system permease family
YR821_2674	COG1129	ABC transporter
YR821_2679	COG1620	l-lactate permease
YR821_2680	COG1304	FMN binding
YR821_2681	COG0579	oxidoreductase
YR821_2682	COG1278	Cold shock
YR821_2688	COG1780	Probably involved in ribonucleotide reductase function
YR821_2689	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YR821_2691	COG4175	Glycine betaine
YR821_2692	COG4176	ABC-type proline glycine betaine transport system permease component
YR821_2693	COG2113	Glycine betaine
YR821_2697	COG1846	Transcriptional regulator
YR821_2699	COG1566	PFAM secretion protein HlyD family protein
YR821_2700	COG2814	Major facilitator Superfamily
YR821_2701	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YR821_2703	COG3118	belongs to the thioredoxin family
YR821_2704	COG3148	PFAM DTW domain containing protein
YR821_2705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YR821_2705	COG1042	CoA-binding domain protein
YR821_2705	COG0045	succinate-CoA ligase (ADP-forming) activity
YR821_2706	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YR821_2707	COG5544	Lipoprotein
YR821_2708	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YR821_2710	COG2011	ABC-type metal ion transport system permease component
YR821_2711	COG1464	Belongs to the NlpA lipoprotein family
YR821_2713	COG1720	tRNA m6t6A37 methyltransferase activity
YR821_2714	COG0442	prolyl-tRNA aminoacylation
YR821_2715	COG3015	lipoprotein NlpE involved in copper resistance
YR821_2717	COG4681	YaeQ
YR821_2719	COG4568	rho-dependent transcription termination
YR821_2722	COG0346	lactoylglutathione lyase activity
YR821_2726	COG0825	malonyl-CoA metabolic process
YR821_2727	COG0587	DNA-directed DNA polymerase activity
YR821_2728	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
YR821_2732	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YR821_2733	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
YR821_2735	COG0750	zinc metalloprotease
YR821_2736	COG0575	Belongs to the CDS family
YR821_2740	COG0528	UMP kinase activity
YR821_2741	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
YR821_2745	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
YR821_2746	COG2171	N-acyltransferase activity
YR821_2749	COG0564	pseudouridine synthase activity
YR821_2750	COG3098	single-species biofilm formation
YR821_2753	COG1611	Belongs to the LOG family
YR821_2755	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
YR821_2756	COG2363	Small membrane protein
YR821_2757	COG0583	DNA-binding transcription factor activity
YR821_2759	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YR821_2760	COG2166	iron-sulfur cluster assembly
YR821_2761	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
YR821_2762	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
YR821_2763	COG0860	N-Acetylmuramoyl-L-alanine amidase
YR821_2764	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
YR821_2764	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
YR821_2765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
YR821_2766	COG1074	ATP-dependent DNA helicase activity
YR821_2767	COG1025	Belongs to the peptidase M16 family
YR821_2768	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
YR821_2769	COG4967	type IV pilus modification protein PilV
YR821_2774	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
YR821_2775	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
YR821_2777	COG3066	DNA modification
YR821_2778	COG0861	Integral membrane protein TerC family
YR821_2779	COG0667	Aldo Keto reductase
YR821_2780	COG0477	Major facilitator Superfamily
YR821_2781	COG0318	PFAM AMP-dependent synthetase and ligase
YR821_2781	COG0204	Acyl-transferase
YR821_2782	COG1609	Transcriptional regulator
YR821_2784	COG0583	DNA-binding transcription factor activity
YR821_2785	COG0583	DNA-binding transcription factor activity
YR821_2797	COG2165	general secretion pathway protein
YR821_2799	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YR821_2807	COG1127	ABC transporter
YR821_2808	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YR821_2816	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
YR821_2817	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
YR821_2818	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
YR821_2819	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YR821_2820	COG4974	Belongs to the 'phage' integrase family
YR821_2821	COG0716	FMN binding
YR821_2823	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
YR821_2825	COG1272	protein, Hemolysin III
YR821_2830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
YR821_2832	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YR821_2833	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YR821_2834	COG0006	proline dipeptidase activity
YR821_2836	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
YR821_2837	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YR821_2838	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YR821_2839	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YR821_2843	COG1279	arginine transmembrane transporter activity
YR821_2845	COG0191	fructose-bisphosphate aldolase activity
YR821_2846	COG0126	phosphoglycerate kinase activity
YR821_2847	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
YR821_2848	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
YR821_2851	COG1166	arginine decarboxylase activity
YR821_2853	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
YR821_2856	COG0640	Transcriptional regulator
YR821_2857	COG3091	SprT-like family
YR821_2858	COG2356	endonuclease I
YR821_2859	COG1385	rRNA (uridine-N3-)-methyltransferase activity
YR821_2860	COG0189	ligase activity
YR821_2861	COG1678	Uncharacterized ACR, COG1678
YR821_2862	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
YR821_2863	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YR821_2865	COG2805	Type II/IV secretion system protein
YR821_2866	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
YR821_2867	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
YR821_2868	COG0762	integral membrane protein
YR821_2869	COG1872	DUF167
YR821_2870	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
YR821_2871	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YR821_2874	COG3171	Protein conserved in bacteria
YR821_2876	COG1194	a g-specific adenine glycosylase
YR821_2877	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
YR821_2878	COG0741	lytic transglycosylase activity
YR821_2879	COG0582	viral genome integration into host DNA
YR821_2880	COG0582	viral genome integration into host DNA
YR821_2884	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YR821_2895	COG3596	GTP binding
YR821_2916	COG1105	Belongs to the carbohydrate kinase PfkB family
YR821_2918	COG1882	Formate acetyltransferase
YR821_2919	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
YR821_2920	COG0814	amino acid
YR821_2924	COG1028	Short-chain dehydrogenase reductase Sdr
YR821_2925	COG3433	isochorismatase activity
YR821_2925	COG1535	isochorismatase
YR821_2926	COG1021	2,3-dihydroxybenzoate-AMP ligase
YR821_2927	COG1169	isochorismate synthase
YR821_2928	COG4592	Periplasmic binding protein
YR821_2930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YR821_2931	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YR821_2932	COG1120	ATPase activity
YR821_2934	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YR821_2935	COG3251	PFAM MbtH domain protein
YR821_2937	COG4774	siderophore transport
YR821_2938	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YR821_2943	COG4964	Belongs to the GSP D family
YR821_2953	COG0848	biopolymer transport protein
YR821_2954	COG0811	peptide transport
YR821_2955	COG0626	cystathionine gamma-synthase activity
YR821_2956	COG0586	Pfam SNARE associated Golgi protein
YR821_2957	COG2207	Transcriptional regulator
YR821_2958	COG1979	alcohol dehydrogenase
YR821_2960	COG0656	L-ascorbic acid biosynthetic process
YR821_2962	COG2132	Multicopper oxidase
YR821_2964	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YR821_2965	COG2249	NAD(P)H dehydrogenase (quinone) activity
YR821_2966	COG0583	DNA-binding transcription factor activity
YR821_2967	COG0187	DNA topoisomerase II activity
YR821_2968	COG3150	esterase
YR821_2969	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YR821_2970	COG3151	Protein conserved in bacteria
YR821_2971	COG0494	nUDIX hydrolase
YR821_2973	COG1538	Outer membrane efflux protein
YR821_2974	COG5463	Belongs to the UPF0441 family
YR821_2975	COG0754	glutathionylspermidine amidase activity
YR821_2976	COG3384	dioxygenase
YR821_2978	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YR821_2981	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
YR821_2981	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
YR821_2983	COG3025	triphosphatase activity
YR821_2984	COG4991	sh3 domain protein
YR821_2985	COG0617	tRNA 3'-terminal CCA addition
YR821_2986	COG1968	undecaprenyl-diphosphatase activity
YR821_2987	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
YR821_2988	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
YR821_2989	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
YR821_2990	COG0828	Belongs to the bacterial ribosomal protein bS21 family
YR821_2991	COG0358	DNA primase activity
YR821_2995	COG1028	Short-chain dehydrogenase reductase Sdr
YR821_3000	COG2801	Transposase and inactivated derivatives
YR821_3002	COG2963	transposase activity
YR821_3005	COG0463	Glycosyl transferase, family 2
YR821_3006	COG2801	Transposase and inactivated derivatives
YR821_3009	COG3210	domain, Protein
YR821_3013	COG3210	domain, Protein
YR821_3018	COG3210	domain, Protein
YR821_3019	COG2831	hemolysin activation secretion protein
YR821_3021	COG0446	pyridine nucleotide-disulphide oxidoreductase
YR821_3021	COG1902	pentaerythritol trinitrate reductase activity
YR821_3024	COG1451	nucleotide metabolic process
YR821_3025	COG0673	inositol 2-dehydrogenase activity
YR821_3026	COG0861	Integral membrane protein TerC family
YR821_3027	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
YR821_3029	COG2721	sulfolactate sulfo-lyase activity
YR821_3033	COG2271	Major facilitator Superfamily
YR821_3036	COG0586	Pfam SNARE associated Golgi protein
YR821_3039	COG4575	ribosome binding
YR821_3040	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
YR821_3042	COG2259	Doxx family
YR821_3043	COG0583	DNA-binding transcription factor activity
YR821_3044	COG1741	Belongs to the pirin family
YR821_3046	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
YR821_3049	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
YR821_3050	COG2823	Periplasmic or secreted lipoprotein
YR821_3051	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YR821_3052	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
YR821_3053	COG2198	Histidine kinase
YR821_3053	COG0784	Response regulator, receiver
YR821_3053	COG5002	protein histidine kinase activity
YR821_3054	COG1242	4 iron, 4 sulfur cluster binding
YR821_3055	COG0070	glutamate synthase
YR821_3055	COG0069	glutamate synthase activity
YR821_3055	COG0067	glutamate synthase
YR821_3056	COG0493	'glutamate synthase
YR821_3058	COG2969	positive regulation of protein catabolic process
YR821_3059	COG0625	glutathione transferase activity
YR821_3060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
YR821_3061	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
YR821_3062	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YR821_3064	COG3105	Protein conserved in bacteria
YR821_3065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YR821_3067	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
YR821_3068	COG5007	Belongs to the BolA IbaG family
YR821_3069	COG3113	response to antibiotic
YR821_3070	COG2854	intermembrane phospholipid transfer
YR821_3071	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YR821_3072	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YR821_3073	COG1127	ABC transporter
YR821_3074	COG0530	calcium, potassium:sodium antiporter activity
YR821_3075	COG0517	IMP dehydrogenase activity
YR821_3075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
YR821_3076	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
YR821_3077	COG3117	lipopolysaccharide transmembrane transporter activity
YR821_3078	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
YR821_3079	COG1137	ATPase activity
YR821_3080	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
YR821_3085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YR821_3087	COG0540	Belongs to the ATCase OTCase family
YR821_3088	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
YR821_3090	COG0366	Alpha amylase catalytic
YR821_3091	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YR821_3091	COG1263	PTS System
YR821_3093	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
YR821_3097	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YR821_3098	COG3783	Cytochrome b(562)
YR821_3099	COG0312	modulator of DNA gyrase
YR821_3100	COG3028	Belongs to the UPF0307 family
YR821_3101	COG2732	(Barnase) inhibitor
YR821_3102	COG4290	ribonuclease
YR821_3104	COG1289	transmembrane transporter activity
YR821_3105	COG1566	PFAM secretion protein HlyD family protein
YR821_3107	COG0583	DNA-binding transcription factor activity
YR821_3108	COG0312	modulator of DNA gyrase
YR821_3109	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YR821_3110	COG3164	Protein of unknown function
YR821_3112	COG0424	maF-like protein
YR821_3113	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
YR821_3114	COG1792	Involved in formation and maintenance of cell shape
YR821_3115	COG1077	Cell shape determining protein MreB Mrl
YR821_3116	COG2200	EAL domain
YR821_3116	COG2199	diguanylate cyclase activity
YR821_3117	COG0604	alcohol dehydrogenase
YR821_3118	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
YR821_3119	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
YR821_3121	COG0511	ligase activity, forming carbon-carbon bonds
YR821_3122	COG0439	Biotin carboxylase
YR821_3123	COG3924	membrane
YR821_3124	COG4145	pantothenate transmembrane transporter activity
YR821_3125	COG2264	protein methyltransferase activity
YR821_3126	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YR821_3127	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
YR821_3129	COG1560	Kdo2-lipid A biosynthetic process
YR821_3131	COG1346	cytolysis
YR821_3132	COG1380	Effector of murein hydrolase LrgA
YR821_3133	COG0583	DNA-binding transcription factor activity
YR821_3134	COG0025	NhaP-type Na H and K H
YR821_3135	COG2252	PERMEase
YR821_3138	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YR821_3139	COG2315	Protein conserved in bacteria
YR821_3140	COG1448	Aminotransferase
YR821_3143	COG0604	alcohol dehydrogenase
YR821_3145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YR821_3146	COG0735	belongs to the Fur family
YR821_3147	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
YR821_3148	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
YR821_3149	COG2937	Belongs to the GPAT DAPAT family
YR821_3154	COG4580	involved in the transport of maltose and maltodextrins
YR821_3159	COG2182	Extracellular solute-binding protein
YR821_3160	COG1175	transmembrane transport
YR821_3161	COG3833	ABC-type maltose transport systems, permease component
YR821_3162	COG3223	Belongs to the PsiE family
YR821_3165	COG0527	aspartate kinase activity
YR821_3168	COG3328	transposase activity
YR821_3170	COG3328	transposase activity
YR821_3175	COG1222	aaa ATPase
YR821_3197	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
YR821_3200	COG0138	bifunctional purine biosynthesis protein purh
YR821_3201	COG0151	Belongs to the GarS family
YR821_3205	COG1515	deoxyribonuclease V activity
YR821_3206	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
YR821_3207	COG2816	NAD+ diphosphatase activity
YR821_3208	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
YR821_3211	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YR821_3212	COG2104	thiamine diphosphate biosynthetic process
YR821_3213	COG2022	thiamine diphosphate biosynthetic process
YR821_3215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YR821_3216	COG0085	RNA polymerase activity
YR821_3217	COG0222	ribosome binding
YR821_3218	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
YR821_3220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
YR821_3221	COG0250	Participates in transcription elongation, termination and antitermination
YR821_3227	COG0812	UDP-N-acetylmuramate dehydrogenase activity
YR821_3228	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
YR821_3229	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YR821_3230	COG1739	Uncharacterized protein family UPF0029
YR821_3232	COG1250	3-hydroxyacyl-CoA dehydrogenase
YR821_3232	COG1024	Enoyl-CoA hydratase
YR821_3234	COG0543	2 iron, 2 sulfur cluster binding
YR821_3237	COG0250	Participates in transcription elongation, termination and antitermination
YR821_3240	COG0805	protein transport
YR821_3241	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YR821_3242	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YR821_3243	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
YR821_3244	COG3165	ubiquinone biosynthetic process from chorismate
YR821_3245	COG2226	methyltransferase
YR821_3246	COG1322	Protein conserved in bacteria
YR821_3247	COG0586	Pfam SNARE associated Golgi protein
YR821_3248	COG1966	Carbon starvation protein
YR821_3252	COG0412	Dienelactone hydrolase
YR821_3253	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
YR821_3254	COG0583	DNA-binding transcription factor activity
YR821_3256	COG0584	glycerophosphoryl diester phosphodiesterase
YR821_3258	COG0395	ABC-type sugar transport system, permease component
YR821_3259	COG1175	transmembrane transport
YR821_3260	COG1653	transport
YR821_3268	COG0410	ABC transporter
YR821_3270	COG4177	L-phenylalanine transmembrane transporter activity
YR821_3274	COG1929	Belongs to the glycerate kinase type-1 family
YR821_3275	COG2610	gluconate transmembrane transporter activity
YR821_3276	COG3835	regulator
YR821_3278	COG2177	Part of the ABC transporter FtsEX involved in
YR821_3279	COG2884	Cell division ATP-binding protein ftsE
YR821_3280	COG0552	protein localization to endoplasmic reticulum
YR821_3280	COG0552	protein localization to endoplasmic reticulum
YR821_3281	COG0742	ribosomal rna small subunit methyltransferase
YR821_3282	COG3776	membrane
YR821_3285	COG3714	YhhN family
YR821_3288	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
YR821_3290	COG0247	lactate metabolic process
YR821_3292	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YR821_3294	COG2271	Major facilitator Superfamily
YR821_3295	COG0584	glycerophosphoryl diester phosphodiesterase
YR821_3296	COG0561	phosphatase activity
YR821_3297	COG2267	carboxylic ester hydrolase activity
YR821_3298	COG1280	lysine exporter protein (LysE YggA)
YR821_3299	COG0514	ATP-dependent DNA helicase (RecQ)
YR821_3300	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
YR821_3301	COG2050	protein possibly involved in aromatic compounds catabolism
YR821_3305	COG5564	TIM-barrel signal transduction protein
YR821_3306	COG5441	Belongs to the UPF0261 family
YR821_3308	COG0210	DNA helicase
YR821_3309	COG1011	Hydrolase
YR821_3310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
YR821_3311	COG3159	Protein conserved in bacteria
YR821_3312	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
YR821_3313	COG5567	small periplasmic lipoprotein
YR821_3315	COG3072	Adenylate cyclase
YR821_3316	COG0181	hydroxymethylbilane synthase activity
YR821_3317	COG1587	Uroporphyrinogen-III synthase
YR821_3318	COG2959	enzyme of heme biosynthesis
YR821_3319	COG3071	HemY protein
YR821_3325	COG2244	polysaccharide biosynthetic process
YR821_3326	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YR821_3327	COG0456	acetyltransferase
YR821_3328	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
YR821_3329	COG1088	dTDP-glucose 4,6-dehydratase activity
YR821_3330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
YR821_3331	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
YR821_3332	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YR821_3333	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YR821_3334	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
YR821_3335	COG3118	belongs to the thioredoxin family
YR821_3337	COG0248	Ppx GppA phosphatase
YR821_3339	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YR821_3342	COG3397	chitin binding
YR821_3344	COG0129	dihydroxy-acid dehydratase activity
YR821_3346	COG3978	acetolactate synthase activity
YR821_3349	COG3085	chromosome segregation
YR821_3350	COG0583	DNA-binding transcription factor activity
YR821_3361	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YR821_3363	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YR821_3363	COG0678	peroxiredoxin activity
YR821_3364	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YR821_3372	COG1629	transport
YR821_3374	COG0165	Argininosuccinate lyase
YR821_3375	COG0137	argininosuccinate synthase activity
YR821_3376	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
YR821_3385	COG0527	aspartate kinase activity
YR821_3385	COG0460	homoserine dehydrogenase
YR821_3386	COG0626	cystathionine gamma-synthase activity
YR821_3387	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
YR821_3389	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YR821_3390	COG1609	Transcriptional regulator
YR821_3391	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YR821_3392	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
YR821_3393	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
YR821_3394	COG1575	Belongs to the MenA family. Type 1 subfamily
YR821_3395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YR821_3396	COG3074	FtsZ-dependent cytokinesis
YR821_3397	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YR821_3398	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YR821_3399	COG1494	fructose-1,6-bisphosphatase
YR821_3400	COG2814	Major facilitator Superfamily
YR821_3402	COG3152	Membrane
YR821_3405	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
YR821_3407	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
YR821_3408	COG3678	ATP-independent chaperone mediated protein folding
YR821_3409	COG0745	RESPONSE REGULATOR receiver
YR821_3410	COG2205	protein histidine kinase activity
YR821_3411	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
YR821_3412	COG1045	serine acetyltransferase
YR821_3413	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
YR821_3414	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
YR821_3415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YR821_3416	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YR821_3417	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YR821_3418	COG4942	peptidase
YR821_3419	COG2861	carbohydrate metabolic process
YR821_3422	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YR821_3423	COG0859	PFAM glycosyl transferase family 9
YR821_3424	COG0859	PFAM glycosyl transferase family 9
YR821_3425	COG1519	Transferase
YR821_3429	COG0267	Belongs to the bacterial ribosomal protein bL33 family
YR821_3430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
YR821_3431	COG2003	Belongs to the UPF0758 family
YR821_3432	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YR821_3433	COG0756	dUTP diphosphatase activity
YR821_3434	COG1309	transcriptional regulator
YR821_3435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
YR821_3436	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
YR821_3437	COG1561	YicC-like family, N-terminal region
YR821_3440	COG5001	Diguanylate cyclase
YR821_3441	COG1024	Enoyl-CoA hydratase
YR821_3442	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YR821_3445	COG2860	membrane
YR821_3446	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YR821_3449	COG1758	RNA polymerase activity
YR821_3450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YR821_3451	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YR821_3452	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YR821_3453	COG0786	glutamate:sodium symporter activity
YR821_3454	COG2233	PERMEase
YR821_3455	COG2982	Protein involved in outer membrane biogenesis
YR821_3456	COG0456	acetyltransferase
YR821_3459	COG1011	Hydrolase
YR821_3462	COG3852	Histidine kinase
YR821_3464	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YR821_3466	COG0218	Necessary for normal cell division and for the maintenance of normal septation
YR821_3467	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YR821_3467	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YR821_3469	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YR821_3470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
YR821_3471	COG3084	Protein conserved in bacteria
YR821_3473	COG1763	Mo-molybdopterin cofactor biosynthetic process
YR821_3474	COG2186	Transcriptional regulator
YR821_3475	COG1609	Transcriptional regulator
YR821_3476	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YR821_3478	COG1172	Belongs to the binding-protein-dependent transport system permease family
YR821_3479	COG1129	ABC transporter
YR821_3480	COG1869	D-ribose catabolic process
YR821_3481	COG3158	transport of potassium into the cell
YR821_3482	COG0714	Associated with various cellular activities
YR821_3483	COG2425	protein containing a von Willebrand factor type A (vWA) domain
YR821_3485	COG2502	aspartate--ammonia ligase
YR821_3486	COG1522	sequence-specific DNA binding
YR821_3487	COG0716	FMN binding
YR821_3488	COG0445	tRNA wobble uridine modification
YR821_3489	COG0357	Ribosomal RNA small subunit methyltransferase G
YR821_3491	COG3312	ion transport
YR821_3492	COG0356	it plays a direct role in the translocation of protons across the membrane
YR821_3494	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
YR821_3496	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
YR821_3497	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
YR821_3499	COG0355	proton-transporting ATP synthase activity, rotational mechanism
YR821_3502	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YR821_3503	COG0573	inorganic phosphate transmembrane transporter activity
YR821_3504	COG0581	inorganic phosphate transmembrane transporter activity
YR821_3506	COG0704	Plays a role in the regulation of phosphate uptake
YR821_3507	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YR821_3508	COG0765	amino acid transport
YR821_3509	COG0765	amino acid transport
YR821_3510	COG2252	PERMEase
YR821_3511	COG0840	transmembrane signaling receptor activity
YR821_3513	COG3121	Chaperone
YR821_3516	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
YR821_3517	COG0706	membrane insertase activity
YR821_3519	COG0594	ribonuclease P activity
YR821_3520	COG0230	Belongs to the bacterial ribosomal protein bL34 family
YR821_p10001	COG1192	Involved in chromosome partitioning
YR821_p10004	COG1192	Involved in chromosome partitioning
YR821_p10013	COG3609	addiction module antidote protein, CC2985 family
YR821_p20009	COG2944	sequence-specific DNA binding
YR821_p20018	COG2801	Transposase and inactivated derivatives
YR821_p20024	COG2963	transposase activity
YR821_p20047	COG1196	nuclear chromosome segregation
YR821_p20076	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YR821_p20079	COG0741	lytic transglycosylase activity