locus-tag	class	description
ND444_00010	COG0592	DNA-directed DNA polymerase activity
ND444_00020	COG0187	DNA topoisomerase II activity
ND444_00025	COG0561	phosphatase activity
ND444_00030	COG0823	Involved in the tonB-independent uptake of proteins
ND444_00035	COG5645	(Lipo)protein
ND444_00050	COG0569	domain protein
ND444_00050	COG2985	domain, Protein
ND444_00055	COG3977	Valine--pyruvate aminotransferase
ND444_00060	COG2885	chlorophyll binding
ND444_00080	COG2818	Glycosylase
ND444_00130	COG2213	PTS system mannitol-specific
ND444_00130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND444_00140	COG3722	fumarate hydratase activity
ND444_00150	COG2258	MOSC domain
ND444_00155	COG0840	transmembrane signaling receptor activity
ND444_00160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND444_00175	COG0437	4 iron, 4 sulfur cluster binding
ND444_00180	COG2864	formate dehydrogenase
ND444_00190	COG1921	L-seryl-tRNASec selenium transferase activity
ND444_00195	COG3276	selenocysteine insertion sequence binding
ND444_00200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND444_00210	COG3274	enterobacterial common antigen metabolic process
ND444_00220	COG0582	viral genome integration into host DNA
ND444_00260	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND444_00265	COG2986	histidine ammonia-lyase
ND444_00285	COG2194	sulfuric ester hydrolase activity
ND444_00290	COG2197	response regulator
ND444_00295	COG3851	Histidine kinase
ND444_00300	COG2271	Major facilitator Superfamily
ND444_00310	COG0747	negative chemotaxis
ND444_00315	COG0601	transmembrane transport
ND444_00320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND444_00325	COG0444	Belongs to the ABC transporter superfamily
ND444_00330	COG4608	Belongs to the ABC transporter superfamily
ND444_00335	COG2194	sulfuric ester hydrolase activity
ND444_00360	COG1215	transferase activity, transferring glycosyl groups
ND444_00365	COG1215	transferase activity, transferring glycosyl groups
ND444_00370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND444_00375	COG0457	Tetratricopeptide repeat
ND444_00375	COG3118	belongs to the thioredoxin family
ND444_00380	COG2199	diguanylate cyclase activity
ND444_00380	COG2200	EAL domain
ND444_00385	COG1301	dicarboxylic acid transport
ND444_00390	COG0612	Peptidase, M16
ND444_00395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND444_00400	COG1942	4-Oxalocrotonate Tautomerase
ND444_00405	COG2200	EAL domain
ND444_00410	COG2134	cdp-diacylglycerol pyrophosphatase
ND444_00415	COG1295	ribonuclease BN
ND444_00425	COG1301	dicarboxylic acid transport
ND444_00430	COG0626	cystathionine gamma-synthase activity
ND444_00445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND444_00450	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND444_00455	COG0339	signal peptide processing
ND444_00460	COG0742	ribosomal rna small subunit methyltransferase
ND444_00470	COG0589	response to stress
ND444_00480	COG0306	phosphate transporter
ND444_00485	COG2081	HI0933 family
ND444_00495	COG1247	-acetyltransferase
ND444_00500	COG1741	Belongs to the pirin family
ND444_00505	COG1609	Transcriptional regulator
ND444_00510	COG2610	gluconate transmembrane transporter activity
ND444_00515	COG3265	gluconokinase activity
ND444_00520	COG2095	MarC family integral membrane protein
ND444_00525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND444_00530	COG3275	phosphorelay sensor kinase activity
ND444_00535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND444_00540	COG1523	belongs to the glycosyl hydrolase 13 family
ND444_00545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND444_00550	COG0297	glycogen (starch) synthase activity
ND444_00555	COG0058	SHG alpha-glucan phosphorylase activity
ND444_00560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND444_00565	COG1349	DNA-binding transcription factor activity
ND444_00570	COG0705	Rhomboid family
ND444_00580	COG2909	trisaccharide binding
ND444_00585	COG0058	SHG alpha-glucan phosphorylase activity
ND444_00590	COG1640	4-alpha-glucanotransferase
ND444_00600	COG1040	competence protein
ND444_00605	COG0596	Alpha beta hydrolase
ND444_00625	COG1918	ferrous iron import across plasma membrane
ND444_00630	COG2183	response to ionizing radiation
ND444_00655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND444_00670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND444_00680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND444_00685	COG1011	Hydrolase
ND444_00695	COG0494	nUDIX hydrolase
ND444_00700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND444_00725	COG4796	Type ii and iii secretion system protein
ND444_00730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND444_00750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND444_00760	COG0180	Tryptophanyl-tRNA synthetase
ND444_00780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND444_00785	COG0402	S-adenosylhomocysteine deaminase activity
ND444_00790	COG0738	Major facilitator superfamily
ND444_00805	COG1609	Transcriptional regulator
ND444_00810	COG1486	melibiose metabolic process
ND444_00815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND444_00830	COG1289	transmembrane transporter activity
ND444_00835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND444_00840	COG1765	OsmC-like protein
ND444_00865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND444_00870	COG3954	Phosphoribulokinase
ND444_00880	COG0429	hydrolase of the alpha beta-hydrolase fold
ND444_00890	COG0859	PFAM glycosyl transferase family 9
ND444_00895	COG1216	Glycosyl transferase, family 2
ND444_00900	COG0488	(ABC) transporter
ND444_00905	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND444_00915	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND444_00920	COG1047	Peptidyl-prolyl cis-trans
ND444_00930	COG0545	Peptidyl-prolyl cis-trans isomerase
ND444_00935	COG2964	Protein conserved in bacteria
ND444_00945	COG2923	Belongs to the DsrF TusC family
ND444_00950	COG2168	tRNA wobble position uridine thiolation
ND444_00955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND444_00960	COG0049	tRNA binding
ND444_00970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND444_00985	COG0051	transcription antitermination factor activity, RNA binding
ND444_00990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND444_01000	COG0089	rRNA binding
ND444_01005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND444_01010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND444_01015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND444_01025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND444_01030	COG0255	Belongs to the universal ribosomal protein uL29 family
ND444_01035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND444_01040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND444_01050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND444_01075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND444_01080	COG1841	ribosomal large subunit assembly
ND444_01085	COG0200	Binds to the 23S rRNA
ND444_01090	COG0201	protein transport
ND444_01095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND444_01100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND444_01110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND444_01120	COG0203	ribosomal protein L17
ND444_01125	COG0789	Transcriptional regulator
ND444_01130	COG3036	rescue of stalled ribosome
ND444_01135	COG1970	mechanosensitive ion channel activity
ND444_01145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND444_01145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND444_01150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND444_01155	COG0242	peptide deformylase activity
ND444_01160	COG0758	DNA mediated transformation
ND444_01165	COG2922	Belongs to the Smg family
ND444_01170	COG0551	DNA topoisomerase type I activity
ND444_01175	COG0009	L-threonylcarbamoyladenylate synthase
ND444_01185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND444_01210	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND444_01255	COG0250	Participates in transcription elongation, termination and antitermination
ND444_01260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND444_01270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND444_01275	COG0222	ribosome binding
ND444_01280	COG0085	RNA polymerase activity
ND444_01285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND444_01295	COG2022	thiamine diphosphate biosynthetic process
ND444_01300	COG2104	thiamine diphosphate biosynthetic process
ND444_01305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND444_01320	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND444_01325	COG2816	NAD+ diphosphatase activity
ND444_01330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND444_01335	COG1515	deoxyribonuclease V activity
ND444_01355	COG0151	Belongs to the GarS family
ND444_01360	COG0138	bifunctional purine biosynthesis protein purh
ND444_01405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND444_01440	COG0583	DNA-binding transcription factor activity
ND444_01520	COG1222	aaa ATPase
ND444_01550	COG0527	aspartate kinase activity
ND444_01560	COG3223	Belongs to the PsiE family
ND444_01565	COG3833	ABC-type maltose transport systems, permease component
ND444_01570	COG1175	transmembrane transport
ND444_01575	COG2182	Extracellular solute-binding protein
ND444_01590	COG4580	involved in the transport of maltose and maltodextrins
ND444_01610	COG2937	Belongs to the GPAT DAPAT family
ND444_01615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND444_01620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND444_01625	COG0735	belongs to the Fur family
ND444_01630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND444_01640	COG0604	alcohol dehydrogenase
ND444_01655	COG1448	Aminotransferase
ND444_01660	COG2315	Protein conserved in bacteria
ND444_01665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND444_01680	COG2252	PERMEase
ND444_01685	COG0025	NhaP-type Na H and K H
ND444_01690	COG0583	DNA-binding transcription factor activity
ND444_01695	COG1380	Effector of murein hydrolase LrgA
ND444_01700	COG1346	cytolysis
ND444_01710	COG1560	Kdo2-lipid A biosynthetic process
ND444_01720	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND444_01725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND444_01730	COG2264	protein methyltransferase activity
ND444_01735	COG4145	pantothenate transmembrane transporter activity
ND444_01740	COG3924	membrane
ND444_01745	COG0439	Biotin carboxylase
ND444_01750	COG0511	ligase activity, forming carbon-carbon bonds
ND444_01760	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND444_01765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND444_01770	COG0604	alcohol dehydrogenase
ND444_01775	COG2199	diguanylate cyclase activity
ND444_01775	COG2200	EAL domain
ND444_01780	COG1077	Cell shape determining protein MreB Mrl
ND444_01785	COG1792	Involved in formation and maintenance of cell shape
ND444_01790	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND444_01795	COG0424	maF-like protein
ND444_01805	COG3164	Protein of unknown function
ND444_01810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND444_01815	COG0312	modulator of DNA gyrase
ND444_01820	COG0583	DNA-binding transcription factor activity
ND444_01830	COG1566	PFAM secretion protein HlyD family protein
ND444_01835	COG1289	transmembrane transporter activity
ND444_01845	COG4290	ribonuclease
ND444_01850	COG2732	(Barnase) inhibitor
ND444_01855	COG3028	Belongs to the UPF0307 family
ND444_01860	COG0312	modulator of DNA gyrase
ND444_01865	COG3783	Cytochrome b(562)
ND444_01870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND444_01880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND444_01890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND444_01890	COG1263	PTS System
ND444_01895	COG0366	Alpha amylase catalytic
ND444_01905	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND444_01910	COG0540	Belongs to the ATCase OTCase family
ND444_01915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND444_01935	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND444_01940	COG1137	ATPase activity
ND444_01945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND444_01950	COG3117	lipopolysaccharide transmembrane transporter activity
ND444_01955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND444_01960	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND444_01960	COG0517	IMP dehydrogenase activity
ND444_01965	COG0530	calcium, potassium:sodium antiporter activity
ND444_01970	COG1127	ABC transporter
ND444_01975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND444_01980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND444_01985	COG2854	intermembrane phospholipid transfer
ND444_01990	COG3113	response to antibiotic
ND444_01995	COG5007	Belongs to the BolA IbaG family
ND444_02000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND444_02010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND444_02015	COG3105	Protein conserved in bacteria
ND444_02020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND444_02025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND444_02030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND444_02035	COG0625	glutathione transferase activity
ND444_02040	COG2969	positive regulation of protein catabolic process
ND444_02050	COG0493	'glutamate synthase
ND444_02055	COG0070	glutamate synthase
ND444_02055	COG0069	glutamate synthase activity
ND444_02055	COG0067	glutamate synthase
ND444_02060	COG1242	4 iron, 4 sulfur cluster binding
ND444_02070	COG5002	protein histidine kinase activity
ND444_02070	COG2198	Histidine kinase
ND444_02070	COG0784	Response regulator, receiver
ND444_02075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND444_02080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND444_02085	COG2823	Periplasmic or secreted lipoprotein
ND444_02090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND444_02105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ND444_02120	COG1741	Belongs to the pirin family
ND444_02125	COG0583	DNA-binding transcription factor activity
ND444_02130	COG2259	Doxx family
ND444_02140	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND444_02145	COG4575	ribosome binding
ND444_02160	COG0586	Pfam SNARE associated Golgi protein
ND444_02175	COG2271	Major facilitator Superfamily
ND444_02190	COG2721	sulfolactate sulfo-lyase activity
ND444_02200	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND444_02205	COG0861	Integral membrane protein TerC family
ND444_02210	COG0673	inositol 2-dehydrogenase activity
ND444_02215	COG1451	nucleotide metabolic process
ND444_02230	COG1902	pentaerythritol trinitrate reductase activity
ND444_02230	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND444_02235	COG2831	hemolysin activation secretion protein
ND444_02240	COG3210	domain, Protein
ND444_02260	COG0463	Glycosyl transferase, family 2
ND444_02355	COG0358	DNA primase activity
ND444_02360	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND444_02365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND444_02370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND444_02375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND444_02380	COG1968	undecaprenyl-diphosphatase activity
ND444_02385	COG0617	tRNA 3'-terminal CCA addition
ND444_02390	COG4991	sh3 domain protein
ND444_02395	COG3025	triphosphatase activity
ND444_02405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND444_02405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND444_02420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND444_02425	COG3384	dioxygenase
ND444_02430	COG0754	glutathionylspermidine amidase activity
ND444_02435	COG5463	Belongs to the UPF0441 family
ND444_02440	COG1538	Outer membrane efflux protein
ND444_02445	COG0494	nUDIX hydrolase
ND444_02450	COG3151	Protein conserved in bacteria
ND444_02455	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND444_02460	COG3150	esterase
ND444_02465	COG0187	DNA topoisomerase II activity
ND444_02470	COG0583	DNA-binding transcription factor activity
ND444_02475	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND444_02480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ND444_02490	COG2132	Multicopper oxidase
ND444_02500	COG0656	L-ascorbic acid biosynthetic process
ND444_02505	COG1979	alcohol dehydrogenase
ND444_02510	COG2207	Transcriptional regulator
ND444_02515	COG0586	Pfam SNARE associated Golgi protein
ND444_02520	COG0626	cystathionine gamma-synthase activity
ND444_02525	COG0811	peptide transport
ND444_02530	COG0848	biopolymer transport protein
ND444_02585	COG4964	Belongs to the GSP D family
ND444_02610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND444_02615	COG4774	siderophore transport
ND444_02625	COG3251	PFAM MbtH domain protein
ND444_02630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND444_02640	COG1120	ATPase activity
ND444_02645	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND444_02650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND444_02660	COG4592	Periplasmic binding protein
ND444_02665	COG1169	isochorismate synthase
ND444_02670	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND444_02675	COG3433	isochorismatase activity
ND444_02675	COG1535	isochorismatase
ND444_02680	COG1028	Short-chain dehydrogenase reductase Sdr
ND444_02695	COG0814	amino acid
ND444_02700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND444_02705	COG1882	Formate acetyltransferase
ND444_02715	COG1105	Belongs to the carbohydrate kinase PfkB family
ND444_02725	COG1349	DNA-binding transcription factor activity
ND444_02730	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND444_02735	COG1028	Short-chain dehydrogenase reductase Sdr
ND444_02740	COG3731	PTS system glucitol sorbitol-specific IIA component
ND444_02745	COG3732	PTS system glucitol sorbitol-specific
ND444_02750	COG3730	PTS system glucitol sorbitol-specific
ND444_02765	COG0583	DNA-binding transcription factor activity
ND444_02835	COG0741	lytic transglycosylase activity
ND444_02840	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND444_02845	COG1194	a g-specific adenine glycosylase
ND444_02855	COG3171	Protein conserved in bacteria
ND444_02870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND444_02875	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND444_02880	COG1872	DUF167
ND444_02885	COG0762	integral membrane protein
ND444_02890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND444_02895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND444_02900	COG2805	Type II/IV secretion system protein
ND444_02910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND444_02915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND444_02920	COG1678	Uncharacterized ACR, COG1678
ND444_02925	COG0189	ligase activity
ND444_02930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND444_02935	COG2356	endonuclease I
ND444_02940	COG3091	SprT-like family
ND444_02945	COG0640	Transcriptional regulator
ND444_02960	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND444_02965	COG1166	arginine decarboxylase activity
ND444_02975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND444_02980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND444_02985	COG0126	phosphoglycerate kinase activity
ND444_02990	COG0191	fructose-bisphosphate aldolase activity
ND444_03000	COG1279	arginine transmembrane transporter activity
ND444_03015	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND444_03020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND444_03025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND444_03035	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND444_03045	COG0006	proline dipeptidase activity
ND444_03050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND444_03055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND444_03060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND444_03080	COG1272	protein, Hemolysin III
ND444_03090	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND444_03100	COG0716	FMN binding
ND444_03105	COG4974	Belongs to the 'phage' integrase family
ND444_03110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND444_03115	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND444_03125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND444_03135	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND444_03140	COG1127	ABC transporter
ND444_03170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND444_03180	COG2165	general secretion pathway protein
ND444_03240	COG0583	DNA-binding transcription factor activity
ND444_03245	COG0583	DNA-binding transcription factor activity
ND444_03255	COG1609	Transcriptional regulator
ND444_03260	COG0204	Acyl-transferase
ND444_03260	COG0318	PFAM AMP-dependent synthetase and ligase
ND444_03265	COG0477	Major facilitator Superfamily
ND444_03270	COG0667	Aldo Keto reductase
ND444_03275	COG0861	Integral membrane protein TerC family
ND444_03280	COG3066	DNA modification
ND444_03290	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND444_03295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND444_03320	COG4967	type IV pilus modification protein PilV
ND444_03325	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND444_03330	COG1025	Belongs to the peptidase M16 family
ND444_03335	COG1074	ATP-dependent DNA helicase activity
ND444_03340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND444_03345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND444_03345	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND444_03350	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND444_03370	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND444_03375	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND444_03380	COG2166	iron-sulfur cluster assembly
ND444_03385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND444_03395	COG0583	DNA-binding transcription factor activity
ND444_03400	COG2363	Small membrane protein
ND444_03405	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND444_03415	COG1611	Belongs to the LOG family
ND444_03430	COG3098	single-species biofilm formation
ND444_03435	COG0564	pseudouridine synthase activity
ND444_03450	COG2171	N-acyltransferase activity
ND444_03455	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND444_03475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND444_03480	COG0528	UMP kinase activity
ND444_03500	COG0575	Belongs to the CDS family
ND444_03505	COG0750	zinc metalloprotease
ND444_03515	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND444_03520	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND444_03540	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND444_03545	COG0587	DNA-directed DNA polymerase activity
ND444_03550	COG0825	malonyl-CoA metabolic process
ND444_03565	COG0346	lactoylglutathione lyase activity
ND444_03580	COG4568	rho-dependent transcription termination
ND444_03590	COG4681	YaeQ
ND444_03600	COG3015	lipoprotein NlpE involved in copper resistance
ND444_03605	COG0442	prolyl-tRNA aminoacylation
ND444_03610	COG1720	tRNA m6t6A37 methyltransferase activity
ND444_03620	COG1464	Belongs to the NlpA lipoprotein family
ND444_03625	COG2011	ABC-type metal ion transport system permease component
ND444_03635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND444_03665	COG5544	Lipoprotein
ND444_03670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND444_03675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND444_03675	COG1042	CoA-binding domain protein
ND444_03675	COG0045	succinate-CoA ligase (ADP-forming) activity
ND444_03680	COG3148	PFAM DTW domain containing protein
ND444_03685	COG3118	belongs to the thioredoxin family
ND444_03690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND444_03695	COG2814	Major facilitator Superfamily
ND444_03700	COG1566	PFAM secretion protein HlyD family protein
ND444_03710	COG1846	Transcriptional regulator
ND444_03715	COG2814	Major facilitator Superfamily
ND444_03725	COG2113	Glycine betaine
ND444_03730	COG4176	ABC-type proline glycine betaine transport system permease component
ND444_03735	COG4175	Glycine betaine
ND444_03745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND444_03750	COG1780	Probably involved in ribonucleotide reductase function
ND444_03780	COG1278	Cold shock
ND444_03785	COG0579	oxidoreductase
ND444_03790	COG1304	FMN binding
ND444_03795	COG1620	l-lactate permease
ND444_03815	COG1129	ABC transporter
ND444_03820	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND444_03830	COG1069	ribulokinase activity
ND444_03915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND444_03965	COG0582	viral genome integration into host DNA
ND444_03975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND444_03980	COG2867	negative regulation of translational initiation
ND444_03990	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND444_03995	COG0497	DNA recombination
ND444_04000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND444_04005	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND444_04015	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND444_04030	COG0513	Belongs to the DEAD box helicase family
ND444_04040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND444_04050	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND444_04060	COG3086	response to oxidative stress
ND444_04065	COG0481	GTPase activity
ND444_04080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND444_04090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND444_04100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND444_04105	COG1737	Transcriptional regulator
ND444_04115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND444_04115	COG1263	PTS System
ND444_04120	COG0560	Phosphoserine phosphatase
ND444_04130	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND444_04145	COG2205	protein histidine kinase activity
ND444_04150	COG3170	Tfp pilus assembly protein FimV
ND444_04155	COG2204	response regulator
ND444_04160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND444_04160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND444_04165	COG0347	Belongs to the P(II) protein family
ND444_04180	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND444_04185	COG3457	Alanine racemase
ND444_04195	COG2188	Transcriptional regulator
ND444_04200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND444_04200	COG1017	nitric oxide dioxygenase activity
ND444_04210	COG2814	Major facilitator Superfamily
ND444_04215	COG3711	transcriptional antiterminator
ND444_04220	COG3683	transport system, periplasmic component
ND444_04225	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND444_04235	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND444_04240	COG1959	2 iron, 2 sulfur cluster binding
ND444_04250	COG0822	iron-sulfur transferase activity
ND444_04265	COG0443	Heat shock 70 kDa protein
ND444_04270	COG0633	Ferredoxin
ND444_04275	COG2975	iron-sulfur cluster assembly
ND444_04290	COG2373	Large extracellular alpha-helical protein
ND444_04295	COG4953	penicillin-binding protein 1C
ND444_04310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND444_04330	COG0124	histidyl-tRNA synthetase
ND444_04335	COG2976	Protein conserved in bacteria
ND444_04340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND444_04350	COG1645	bacterial-type flagellum-dependent swarming motility
ND444_04355	COG1570	exodeoxyribonuclease VII activity
ND444_04360	COG0517	IMP dehydrogenase activity
ND444_04360	COG0516	GMP reductase activity
ND444_04365	COG0519	Catalyzes the synthesis of GMP from XMP
ND444_04365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND444_04375	COG0351	phosphomethylpyrimidine kinase
ND444_04390	COG1597	lipid kinase activity
ND444_04395	COG0826	peptidase U32
ND444_04400	COG3422	double-strand break repair
ND444_04405	COG0745	RESPONSE REGULATOR receiver
ND444_04410	COG2205	protein histidine kinase activity
ND444_04415	COG0477	Major facilitator Superfamily
ND444_04420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND444_04430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND444_04445	COG3121	Chaperone
ND444_04455	COG0443	Heat shock 70 kDa protein
ND444_04460	COG2239	Acts as a magnesium transporter
ND444_04475	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND444_04480	COG0573	inorganic phosphate transmembrane transporter activity
ND444_04485	COG0581	inorganic phosphate transmembrane transporter activity
ND444_04495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND444_04500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND444_04505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND444_04510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND444_04515	COG2233	PERMEase
ND444_04520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND444_04525	COG1393	Belongs to the ArsC family
ND444_04530	COG4783	chaperone-mediated protein folding
ND444_04535	COG0628	permease
ND444_04540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND444_04545	COG2716	regulation of RNA biosynthetic process
ND444_04550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND444_04555	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND444_04575	COG0400	carboxylic ester hydrolase activity
ND444_04585	COG1876	peptidase activity
ND444_04590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND444_04595	COG1393	Belongs to the ArsC family
ND444_04600	COG1605	Chorismate mutase
ND444_04610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND444_04620	COG2197	response regulator
ND444_04625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND444_04625	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND444_04630	COG3062	negative regulation of establishment of protein localization
ND444_04635	COG0243	molybdopterin cofactor binding
ND444_04640	COG3043	anaerobic respiration
ND444_04645	COG3005	denitrification pathway
ND444_04650	COG0494	nUDIX hydrolase
ND444_04655	COG0280	phosphate acetyltransferase
ND444_04655	COG0281	malic enzyme
ND444_04660	COG1671	Belongs to the UPF0178 family
ND444_04675	COG3111	PFAM Bacterial OB fold (BOF) protein
ND444_04685	COG2837	iron assimilation
ND444_04690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND444_04705	COG2731	YhcH YjgK YiaL family protein
ND444_04710	COG1737	Transcriptional regulator
ND444_04720	COG4150	thiosulfate binding
ND444_04725	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND444_04730	COG4208	sulfate ABC transporter
ND444_04740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND444_04755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND444_04765	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND444_04775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND444_04780	COG3530	Putative quorum-sensing-regulated virulence factor
ND444_04835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND444_04840	COG1914	H( )-stimulated, divalent metal cation uptake system
ND444_04860	COG0837	glucose binding
ND444_04865	COG2223	nitrite transmembrane transporter activity
ND444_04870	COG3279	Response regulator of the LytR AlgR family
ND444_04875	COG3275	phosphorelay sensor kinase activity
ND444_04885	COG0436	Aminotransferase
ND444_04890	COG3038	cytochrome b561
ND444_04900	COG1598	PFAM Uncharacterised protein family UPF0150
ND444_04905	COG2951	lytic endotransglycosylase activity
ND444_04910	COG2824	Alkylphosphonate utilization operon protein PhnA
ND444_04975	COG0582	viral genome integration into host DNA
ND444_04990	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND444_04995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND444_05000	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND444_05005	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND444_05010	COG1138	Cytochrome C-type biogenesis protein
ND444_05015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND444_05020	COG4235	cytochrome complex assembly
ND444_05020	COG3088	subunit of a heme lyase
ND444_05025	COG3088	subunit of a heme lyase
ND444_05025	COG4235	cytochrome complex assembly
ND444_05040	COG3691	Protein conserved in bacteria
ND444_05045	COG0183	Belongs to the thiolase family
ND444_05050	COG1024	Enoyl-CoA hydratase
ND444_05050	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND444_05055	COG2062	phosphohistidine phosphatase, SixA
ND444_05060	COG2840	Smr protein MutS2
ND444_05065	COG2890	protein-(glutamine-N5) methyltransferase activity
ND444_05075	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND444_05080	COG0730	response to heat
ND444_05085	COG3101	peptidyl-lysine hydroxylation
ND444_05100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND444_05130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND444_05135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND444_05160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND444_05170	COG0586	Pfam SNARE associated Golgi protein
ND444_05180	COG0285	dihydrofolate synthase activity
ND444_05185	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND444_05190	COG1286	toxin biosynthetic process
ND444_05195	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND444_05200	COG0163	prenyltransferase activity
ND444_05215	COG4215	(ABC) transporter
ND444_05220	COG4160	amino acid transport
ND444_05230	COG1090	epimerase
ND444_05235	COG0625	glutathione transferase activity
ND444_05245	COG0622	Phosphoesterase
ND444_05250	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND444_05255	COG3037	sugar-specific permease SgaT UlaA
ND444_05270	COG1609	Transcriptional regulator
ND444_05275	COG0857	belongs to the CobB CobQ family
ND444_05275	COG0280	phosphate acetyltransferase
ND444_05285	COG3092	negative regulation of chromosome organization
ND444_05290	COG3013	Belongs to the UPF0304 family
ND444_05300	COG0471	metal ion transport
ND444_05300	COG0490	domain, Protein
ND444_05305	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND444_05310	COG0436	Aminotransferase
ND444_05315	COG0583	DNA-binding transcription factor activity
ND444_05320	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND444_05325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND444_05345	COG1034	ATP synthesis coupled electron transport
ND444_05350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND444_05355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND444_05360	COG0839	Belongs to the complex I subunit 6 family
ND444_05370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND444_05375	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND444_05390	COG4575	ribosome binding
ND444_05395	COG1169	isochorismate synthase
ND444_05400	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND444_05405	COG0596	Alpha beta hydrolase
ND444_05410	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND444_05435	COG0814	amino acid
ND444_05450	COG2246	polysaccharide biosynthetic process
ND444_05460	COG4574	serine-type endopeptidase inhibitor activity
ND444_05470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND444_05480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND444_05485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND444_05495	COG2205	protein histidine kinase activity
ND444_05495	COG0784	Response regulator, receiver
ND444_05505	COG2198	Histidine kinase
ND444_05505	COG0642	Histidine kinase
ND444_05510	COG2223	nitrite transmembrane transporter activity
ND444_05530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND444_05535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND444_05585	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND444_05590	COG5532	Uncharacterized conserved protein (DUF2303)
ND444_05640	COG4626	Terminase
ND444_05640	COG1802	Transcriptional regulator
ND444_05645	COG4725	Belongs to the MT-A70-like family
ND444_05660	COG1403	HNH endonuclease
ND444_05685	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ND444_05725	COG4626	Terminase
ND444_05725	COG1802	Transcriptional regulator
ND444_05735	COG4695	Portal protein
ND444_05780	COG4386	tail sheath protein
ND444_05825	COG3299	homolog of phage Mu protein gp47
ND444_05830	COG3778	Protein conserved in bacteria
ND444_05855	COG3083	sulfuric ester hydrolase activity
ND444_05860	COG3082	Protein of unknown function (DUF1414)
ND444_05875	COG1061	Type III restriction enzyme res subunit
ND444_05880	COG1187	pseudouridine synthase activity
ND444_05885	COG2814	Major facilitator Superfamily
ND444_05895	COG4172	Belongs to the ABC transporter superfamily
ND444_05900	COG4239	(ABC) transporter, permease
ND444_05905	COG4174	ABC transporter (Permease)
ND444_05910	COG4166	transmembrane transport
ND444_05915	COG2200	EAL domain
ND444_05920	COG0791	NLP P60 protein
ND444_05925	COG0671	phosphoesterase, PA-phosphatase related
ND444_05930	COG0523	cobalamin synthesis protein
ND444_05940	COG0246	Mannitol dehydrogenase
ND444_05950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND444_05965	COG0243	molybdopterin cofactor binding
ND444_05970	COG3005	denitrification pathway
ND444_05985	COG1105	Belongs to the carbohydrate kinase PfkB family
ND444_05990	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND444_05990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND444_05990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND444_05995	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND444_06000	COG2855	membrane
ND444_06010	COG0583	DNA-binding transcription factor activity
ND444_06015	COG0833	amino acid
ND444_06025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND444_06035	COG4771	TonB-dependent receptor
ND444_06040	COG0531	amino acid
ND444_06045	COG2925	Exonuclease
ND444_06055	COG1289	transmembrane transporter activity
ND444_06075	COG3842	ATPase activity
ND444_06085	COG1840	ABC-type Fe3 transport system, periplasmic component
ND444_06090	COG2271	Major facilitator Superfamily
ND444_06105	COG4565	transcriptional regulatory protein
ND444_06110	COG3290	protein histidine kinase activity
ND444_06115	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND444_06120	COG3052	prosthetic group binding
ND444_06125	COG2301	Belongs to the HpcH HpaI aldolase family
ND444_06130	COG3051	citrate lyase alpha subunit
ND444_06145	COG0471	metal ion transport
ND444_06190	COG3423	Transcriptional regulator
ND444_06205	COG0582	viral genome integration into host DNA
ND444_06240	COG1028	Short-chain dehydrogenase reductase Sdr
ND444_06240	COG3321	synthase
ND444_06240	COG0604	alcohol dehydrogenase
ND444_06250	COG1609	Transcriptional regulator
ND444_06270	COG0840	transmembrane signaling receptor activity
ND444_06275	COG1285	pathogenesis
ND444_06285	COG0589	response to stress
ND444_06305	COG1360	Flagellar Motor Protein
ND444_06310	COG0643	Histidine kinase
ND444_06310	COG2198	Histidine kinase
ND444_06315	COG0835	chemotaxis
ND444_06320	COG0840	transmembrane signaling receptor activity
ND444_06325	COG0840	transmembrane signaling receptor activity
ND444_06330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND444_06340	COG0745	RESPONSE REGULATOR receiver
ND444_06345	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND444_06350	COG4935	Belongs to the peptidase S8 family
ND444_06350	COG1404	Belongs to the peptidase S8 family
ND444_06355	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND444_06360	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND444_06370	COG3418	PFAM FlgN family protein
ND444_06375	COG2747	anti-sigma28 factor FlgM
ND444_06385	COG1815	bacterial-type flagellum-dependent cell motility
ND444_06390	COG1558	bacterial-type flagellum-dependent cell motility
ND444_06470	COG1580	Controls the rotational direction of flagella during chemotaxis
ND444_06485	COG1157	protein secretion by the type III secretion system
ND444_06495	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND444_06505	COG1677	Flagellar hook-basal body complex protein FliE
ND444_06515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND444_06520	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND444_06560	COG1191	sigma factor activity
ND444_06570	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND444_06575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND444_06580	COG0765	amino acid transport
ND444_06585	COG1126	abc transporter atp-binding protein
ND444_06590	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND444_06590	COG0506	proline dehydrogenase activity
ND444_06590	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND444_06595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND444_06600	COG3710	Transcriptional regulator
ND444_06605	COG0531	amino acid
ND444_06615	COG1113	amino acid transport
ND444_06640	COG2197	response regulator
ND444_06645	COG0322	excinuclease ABC activity
ND444_06650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND444_06670	COG2801	Transposase and inactivated derivatives
ND444_06675	COG0840	transmembrane signaling receptor activity
ND444_06710	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND444_06715	COG2153	protein acetylation
ND444_06750	COG0531	amino acid
ND444_06755	COG0076	glutamate decarboxylase activity
ND444_06770	COG2235	arginine
ND444_06785	COG1757	Na H antiporter
ND444_06790	COG3122	Protein conserved in bacteria
ND444_06800	COG1187	pseudouridine synthase activity
ND444_06805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND444_06810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND444_06815	COG2723	6-phospho-beta-galactosidase activity
ND444_06820	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND444_06825	COG2169	Transcriptional regulator
ND444_06825	COG1917	Cupin 2, conserved barrel domain protein
ND444_06840	COG1278	Cold shock
ND444_06845	COG1278	Cold shock
ND444_06865	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND444_06885	COG5001	Diguanylate cyclase
ND444_06885	COG4251	negative regulation of phosphorylation
ND444_06885	COG3706	GGDEF domain
ND444_06885	COG2203	Gaf domain
ND444_06895	COG1132	(ABC) transporter
ND444_06915	COG2207	Transcriptional regulator
ND444_06950	COG1113	amino acid transport
ND444_06970	COG1496	oxidoreductase activity
ND444_06975	COG0768	penicillin binding
ND444_06980	COG2226	methyltransferase
ND444_07010	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND444_07020	COG1960	acyl-CoA dehydrogenase activity
ND444_07040	COG1971	Probably functions as a manganese efflux pump
ND444_07045	COG4811	Protein of unknown function (DUF986)
ND444_07050	COG3716	PTS system mannose fructose sorbose family IID component
ND444_07055	COG3715	PTS system
ND444_07060	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND444_07060	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND444_07065	COG1253	flavin adenine dinucleotide binding
ND444_07070	COG1760	l-serine dehydratase
ND444_07075	COG0494	nUDIX hydrolase
ND444_07095	COG0513	Belongs to the DEAD box helicase family
ND444_07100	COG3141	response to X-ray
ND444_07105	COG3097	Belongs to the UPF0267 family
ND444_07115	COG1770	oligopeptidase
ND444_07120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND444_07135	COG1528	Iron-storage protein
ND444_07140	COG2372	response to copper ion
ND444_07145	COG1276	copper resistance
ND444_07265	COG1674	ftsk spoiiie
ND444_07265	COG1178	ABC-type Fe3 transport system permease component
ND444_07320	COG3772	lysozyme
ND444_07525	COG5001	Diguanylate cyclase
ND444_07525	COG4251	negative regulation of phosphorylation
ND444_07525	COG3706	GGDEF domain
ND444_07525	COG2203	Gaf domain
ND444_07530	COG3008	intermembrane lipid transfer
ND444_07535	COG2995	paraquat-inducible protein a
ND444_07540	COG1956	GAF domain-containing protein
ND444_07550	COG0793	Belongs to the peptidase S41A family
ND444_07555	COG0501	Belongs to the peptidase M48B family
ND444_07565	COG2814	Major facilitator Superfamily
ND444_07575	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND444_07580	COG1823	symporter activity
ND444_07585	COG1988	membrane-bound metal-dependent
ND444_07590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND444_07600	COG3001	Fructosamine kinase
ND444_07605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND444_07610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND444_07615	COG1121	(ABC) transporter
ND444_07620	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND444_07690	COG0776	regulation of translation
ND444_07730	COG4974	Belongs to the 'phage' integrase family
ND444_07735	COG4139	cobalamin transport
ND444_07745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND444_07750	COG0463	Glycosyl transferase, family 2
ND444_07765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND444_07770	COG2076	Multidrug Resistance protein
ND444_07775	COG2076	Multidrug Resistance protein
ND444_07780	COG0791	NLP P60 protein
ND444_07785	COG0095	Lipoate-protein ligase
ND444_07795	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND444_07800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND444_07805	COG4558	Periplasmic binding protein
ND444_07810	COG3720	iron ion transport
ND444_07815	COG4771	TonB-dependent receptor
ND444_07825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND444_07830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND444_07835	COG0574	Belongs to the PEP-utilizing enzyme family
ND444_07835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND444_07845	COG0628	permease
ND444_07850	COG0277	FAD linked oxidase domain protein
ND444_07850	COG0247	lactate metabolic process
ND444_07855	COG2050	protein possibly involved in aromatic compounds catabolism
ND444_07860	COG0316	Belongs to the HesB IscA family
ND444_07865	COG0719	Fe-S assembly protein
ND444_07870	COG0396	ATPase activity
ND444_07875	COG0719	Fe-S assembly protein
ND444_07885	COG2166	iron-sulfur cluster assembly
ND444_07890	COG1388	LysM domain
ND444_07890	COG1376	ErfK ybiS ycfS ynhG family protein
ND444_07925	COG0307	riboflavin synthase, alpha
ND444_07930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND444_07935	COG2814	Major facilitator Superfamily
ND444_07940	COG0583	DNA-binding transcription factor activity
ND444_07945	COG1609	Transcriptional regulator
ND444_07955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND444_07960	COG0791	NLP P60 protein
ND444_07965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND444_07980	COG1902	pentaerythritol trinitrate reductase activity
ND444_07985	COG1309	transcriptional regulator
ND444_07990	COG2194	sulfuric ester hydrolase activity
ND444_07995	COG3313	Fe-S protein
ND444_08000	COG4989	oxidoreductase activity
ND444_08010	COG1846	Transcriptional regulator
ND444_08015	COG3133	Outer membrane lipoprotein
ND444_08020	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND444_08065	COG0484	heat shock protein binding
ND444_08075	COG3104	oligopeptide transport
ND444_08085	COG4172	Belongs to the ABC transporter superfamily
ND444_08090	COG4172	Belongs to the ABC transporter superfamily
ND444_08095	COG4171	peptide transport system, permease
ND444_08105	COG4166	transmembrane transport
ND444_08120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND444_08125	COG1842	Phage shock protein A
ND444_08135	COG1983	PspC domain protein
ND444_08145	COG3106	COG3106 Predicted ATPase
ND444_08150	COG3768	UPF0283 membrane protein
ND444_08155	COG5654	RES domain protein
ND444_08160	COG5642	Protein of unknown function (DUF2384)
ND444_08170	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND444_08175	COG4948	Mandelate Racemase Muconate Lactonizing
ND444_08180	COG2866	Carboxypeptidase
ND444_08185	COG4166	transmembrane transport
ND444_08200	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND444_08200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND444_08200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND444_08200	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND444_08210	COG1285	pathogenesis
ND444_08215	COG3042	response to heat
ND444_08220	COG3187	Heat shock protein
ND444_08225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND444_08230	COG2911	Protein conserved in bacteria
ND444_08245	COG3784	Protein of unknown function (DUF1318)
ND444_08250	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND444_08255	COG1643	Atp-dependent helicase
ND444_08260	COG3591	Belongs to the peptidase S1B family
ND444_08270	COG1881	PFAM PEBP family protein
ND444_08275	COG2207	Transcriptional regulator
ND444_08290	COG2205	protein histidine kinase activity
ND444_08295	COG0745	RESPONSE REGULATOR receiver
ND444_08305	COG0531	amino acid
ND444_08315	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND444_08320	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND444_08325	COG3623	hexulose-6-phosphate isomerase
ND444_08330	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND444_08360	COG0589	response to stress
ND444_08365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND444_08370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND444_08375	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND444_08385	COG1011	Hydrolase
ND444_08425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND444_08445	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND444_08450	COG4221	oxidoreductase activity
ND444_08455	COG1742	UPF0060 membrane protein
ND444_08475	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND444_08480	COG1940	carbohydrate kinase activity
ND444_08500	COG0114	fumarate hydratase activity
ND444_08505	COG1482	cell wall glycoprotein biosynthetic process
ND444_08510	COG5339	Protein conserved in bacteria
ND444_08530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND444_08535	COG0385	Bile acid
ND444_08550	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND444_08560	COG4657	Part of a membrane complex involved in electron transport
ND444_08575	COG3708	Transcriptional regulator
ND444_08575	COG2207	Transcriptional regulator
ND444_08585	COG4659	FMN binding
ND444_08595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND444_08600	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND444_08605	COG5002	protein histidine kinase activity
ND444_08605	COG5001	Diguanylate cyclase
ND444_08605	COG3447	MASE1 domain protein
ND444_08610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND444_08620	COG0023	Translation Initiation Factor
ND444_08635	COG4974	Belongs to the 'phage' integrase family
ND444_08690	COG0463	Glycosyl transferase, family 2
ND444_08725	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND444_08730	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND444_08735	COG0671	phosphoesterase, PA-phosphatase related
ND444_08745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND444_08765	COG0583	DNA-binding transcription factor activity
ND444_08780	COG0616	signal peptide processing
ND444_08785	COG1028	Short-chain dehydrogenase reductase Sdr
ND444_08795	COG1187	pseudouridine synthase activity
ND444_08800	COG0009	L-threonylcarbamoyladenylate synthase
ND444_08805	COG0613	PHP domain protein
ND444_08815	COG0512	Glutamine amidotransferase of anthranilate synthase
ND444_08825	COG0135	phosphoribosylanthranilate isomerase activity
ND444_08825	COG0134	indole-3-glycerol-phosphate synthase activity
ND444_08830	COG0133	tryptophan synthase activity
ND444_08845	COG3047	cAMP biosynthetic process
ND444_08850	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND444_08875	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND444_08910	COG3710	Transcriptional regulator
ND444_08925	COG2350	Protein conserved in bacteria
ND444_08945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND444_08950	COG3099	Belongs to the UPF0263 family
ND444_08965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND444_08980	COG4166	transmembrane transport
ND444_08985	COG2095	MarC family integral membrane protein
ND444_08995	COG1454	alcohol dehydrogenase
ND444_08995	COG1012	belongs to the aldehyde dehydrogenase family
ND444_09015	COG0745	RESPONSE REGULATOR receiver
ND444_09020	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND444_09030	COG0788	formyltetrahydrofolate deformylase activity
ND444_09060	COG0708	Exodeoxyribonuclease III
ND444_09065	COG0494	nUDIX hydrolase
ND444_09075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND444_09085	COG0778	Nitroreductase
ND444_09090	COG0616	signal peptide processing
ND444_09095	COG0252	asparaginase activity
ND444_09100	COG1335	isochorismatase
ND444_09105	COG3139	Protein of unknown function (DUF1315)
ND444_09110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND444_09125	COG2194	sulfuric ester hydrolase activity
ND444_09130	COG3713	MltA-interacting MipA family protein
ND444_09140	COG2766	serine protein kinase
ND444_09145	COG2718	Belongs to the UPF0229 family
ND444_09165	COG2199	diguanylate cyclase activity
ND444_09165	COG2200	EAL domain
ND444_09165	COG2202	Pas domain
ND444_09175	COG2814	Major facilitator Superfamily
ND444_09180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND444_09185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND444_09190	COG2719	SpoVR family
ND444_09200	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND444_09220	COG2983	Belongs to the UPF0260 family
ND444_09225	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND444_09230	COG3100	YcgL domain-containing protein
ND444_09235	COG0850	regulation of cytokinetic process
ND444_09240	COG2894	cell division
ND444_09245	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND444_09250	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND444_09255	COG0318	PFAM AMP-dependent synthetase and ligase
ND444_09260	COG3065	identical protein binding
ND444_09265	COG1214	PFAM Peptidase M22, glycoprotease
ND444_09270	COG1199	ATP-dependent helicase activity
ND444_09275	COG0251	oxidation-reduction process
ND444_09280	COG2076	Multidrug Resistance protein
ND444_09290	COG0800	Aldolase
ND444_09295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND444_09300	COG1737	Transcriptional regulator
ND444_09305	COG0469	pyruvate kinase activity
ND444_09310	COG1560	Kdo2-lipid A biosynthetic process
ND444_09315	COG0739	heme binding
ND444_09320	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND444_09325	COG1121	(ABC) transporter
ND444_09330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND444_09335	COG3104	oligopeptide transport
ND444_09340	COG2255	four-way junction helicase activity
ND444_09345	COG0632	four-way junction helicase activity
ND444_09350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND444_09360	COG0494	nUDIX hydrolase
ND444_09365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND444_09375	COG1801	Protein of unknown function DUF72
ND444_09380	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND444_09395	COG3142	Participates in the control of copper homeostasis
ND444_09400	COG3102	Protein conserved in bacteria
ND444_09425	COG0728	peptidoglycan biosynthetic process
ND444_09430	COG0673	inositol 2-dehydrogenase activity
ND444_09440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND444_09460	COG3381	protein complex oligomerization
ND444_09470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND444_09495	COG3706	GGDEF domain
ND444_09500	COG0659	secondary active sulfate transmembrane transporter activity
ND444_09505	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND444_09520	COG2890	protein-(glutamine-N5) methyltransferase activity
ND444_09525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND444_09530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND444_09535	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND444_09545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND444_09555	COG0193	aminoacyl-tRNA hydrolase activity
ND444_09565	COG0012	GTP binding
ND444_09585	COG0309	Hydrogenase expression formation protein (HypE)
ND444_09590	COG0409	Hydrogenase expression formation protein
ND444_09595	COG0298	carbon dioxide binding
ND444_09600	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND444_09605	COG0375	protein maturation
ND444_09615	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND444_09620	COG0651	ATP synthesis coupled electron transport
ND444_09625	COG0650	Formate hydrogenlyase subunit 4
ND444_09630	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND444_09630	COG3261	NADH dehydrogenase
ND444_09635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND444_09640	COG3260	NADH ubiquinone oxidoreductase 20
ND444_09650	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND444_09655	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND444_09660	COG3383	formate dehydrogenase (NAD+) activity
ND444_09665	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND444_09670	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND444_09690	COG0402	S-adenosylhomocysteine deaminase activity
ND444_09700	COG1228	amidohydrolase
ND444_09720	COG3724	N-succinylarginine dihydrolase activity
ND444_09730	COG3138	arginine N-succinyltransferase
ND444_09735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND444_09740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND444_09745	COG1271	oxidase subunit
ND444_09750	COG1294	oxidase, subunit
ND444_09760	COG3850	Histidine kinase
ND444_09765	COG2375	cellular response to nickel ion
ND444_09770	COG0387	Pfam Sodium calcium exchanger
ND444_09775	COG1702	phosphate starvation-inducible protein PhoH
ND444_09780	COG4977	sequence-specific DNA binding
ND444_09820	COG0471	metal ion transport
ND444_09825	COG3290	protein histidine kinase activity
ND444_09830	COG4565	transcriptional regulatory protein
ND444_09835	COG3493	citrate carrier protein
ND444_09840	COG0840	transmembrane signaling receptor activity
ND444_09845	COG0840	transmembrane signaling receptor activity
ND444_09850	COG0339	signal peptide processing
ND444_09855	COG2723	6-phospho-beta-galactosidase activity
ND444_09860	COG3916	Acyl-homoserine-lactone synthase
ND444_09865	COG2771	luxR family
ND444_09870	COG0538	isocitrate dehydrogenase activity
ND444_09875	COG1187	pseudouridine synthase activity
ND444_09885	COG0482	sulfurtransferase activity
ND444_09890	COG2915	High frequency lysogenization protein hflD homolog
ND444_09895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND444_09905	COG0745	RESPONSE REGULATOR receiver
ND444_09910	COG2205	protein histidine kinase activity
ND444_09915	COG2850	peptidyl-arginine hydroxylation
ND444_09935	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND444_09945	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND444_09950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND444_09955	COG3134	Outer membrane lipoprotein
ND444_09960	COG1252	NADH dehydrogenase
ND444_09965	COG3150	esterase
ND444_09980	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND444_09985	COG5633	Lipoprotein
ND444_09990	COG0537	adenosine 5'-monophosphoramidase activity
ND444_09995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND444_09995	COG1263	PTS System
ND444_10000	COG0084	hydrolase, TatD family'
ND444_10005	COG0470	DNA polymerase III
ND444_10010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND444_10015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND444_10020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND444_10025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND444_10030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND444_10040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND444_10045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND444_10055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND444_10060	COG1399	metal-binding, possibly nucleic acid-binding protein
ND444_10065	COG0424	maF-like protein
ND444_10070	COG0564	pseudouridine synthase activity
ND444_10075	COG1530	ribonuclease E activity
ND444_10085	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND444_10090	COG0418	dihydroorotase activity
ND444_10115	COG0628	permease
ND444_10125	COG1560	Kdo2-lipid A biosynthetic process
ND444_10140	COG0346	lactoylglutathione lyase activity
ND444_10145	COG2943	transferase activity, transferring hexosyl groups
ND444_10150	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND444_10170	COG0288	reversible hydration of carbon dioxide
ND444_10180	COG2920	part of a sulfur-relay system
ND444_10185	COG1254	Belongs to the acylphosphatase family
ND444_10190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND444_10195	COG3785	DNA binding
ND444_10200	COG1832	CoA-binding protein
ND444_10210	COG1803	Methylglyoxal synthase
ND444_10215	COG0210	DNA helicase
ND444_10220	COG3304	Inner membrane component domain
ND444_10225	COG1289	transmembrane transporter activity
ND444_10230	COG3070	regulator of competence-specific genes
ND444_10235	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND444_10245	COG3120	sequence-specific DNA binding
ND444_10250	COG1067	ATP-dependent peptidase activity
ND444_10255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND444_10260	COG3130	regulation of translation
ND444_10265	COG3009	Protein conserved in bacteria
ND444_10270	COG3008	intermembrane lipid transfer
ND444_10270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND444_10275	COG2995	paraquat-inducible protein a
ND444_10280	COG0488	(ABC) transporter
ND444_10285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND444_10285	COG0116	Belongs to the methyltransferase superfamily
ND444_10290	COG3217	Mosc domain protein beta barrel domain protein
ND444_10290	COG0633	Ferredoxin
ND444_10300	COG0167	dihydroorotate dehydrogenase activity
ND444_10305	COG0308	aminopeptidase N
ND444_10310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND444_10325	COG1448	Aminotransferase
ND444_10330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND444_10335	COG3108	Peptidase M15
ND444_10340	COG2989	Protein conserved in bacteria
ND444_10345	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND444_10355	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND444_10360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND444_10365	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND444_10370	COG3173	Aminoglycoside phosphotransferase
ND444_10375	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND444_10380	COG2835	tetraacyldisaccharide 4'-kinase activity
ND444_10385	COG1278	Cold shock
ND444_10395	COG5383	Protein conserved in bacteria
ND444_10400	COG1663	tetraacyldisaccharide 4'-kinase activity
ND444_10410	COG2333	competence protein COMEC
ND444_10410	COG0658	competence protein
ND444_10420	COG0539	negative regulation of cytoplasmic translation
ND444_10430	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND444_10440	COG0252	asparaginase activity
ND444_10445	COG1944	ATP diphosphatase activity
ND444_10450	COG2116	formate transmembrane transporter activity
ND444_10455	COG1882	Formate acetyltransferase
ND444_10460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND444_10465	COG2814	Major facilitator Superfamily
ND444_10470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND444_10475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND444_10480	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND444_10485	COG3107	peptidoglycan biosynthetic process
ND444_10485	COG1674	ftsk spoiiie
ND444_10490	COG1522	sequence-specific DNA binding
ND444_10495	COG0492	ferredoxin-NADP+ reductase activity
ND444_10505	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND444_10515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND444_10520	COG0542	response to heat
ND444_10525	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND444_10530	COG1278	Cold shock
ND444_10540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND444_10545	COG2990	Protein conserved in bacteria
ND444_10550	COG3593	DNA synthesis involved in DNA repair
ND444_10555	COG2431	L-lysine efflux transmembrane transporter activity
ND444_10560	COG1151	hydroxylamine reductase activity
ND444_10565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND444_10570	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND444_10575	COG0702	epimerase
ND444_10580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND444_10585	COG0393	Putative heavy-metal-binding
ND444_10595	COG1126	abc transporter atp-binding protein
ND444_10600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND444_10605	COG4215	(ABC) transporter
ND444_10610	COG4160	amino acid transport
ND444_10615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND444_10630	COG1177	transmembrane transport
ND444_10635	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND444_10640	COG3842	ATPase activity
ND444_10645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND444_10665	COG0569	domain protein
ND444_10665	COG2985	domain, Protein
ND444_10675	COG0671	phosphoesterase, PA-phosphatase related
ND444_10685	COG1349	DNA-binding transcription factor activity
ND444_10690	COG0814	amino acid
ND444_10695	COG1760	l-serine dehydratase
ND444_10700	COG1686	Belongs to the peptidase S11 family
ND444_10710	COG0626	cystathionine gamma-synthase activity
ND444_10725	COG0625	glutathione transferase activity
ND444_10730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND444_10745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND444_10750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND444_10755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND444_10755	COG0131	Imidazoleglycerol-phosphate dehydratase
ND444_10765	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND444_10775	COG0140	phosphoribosyl-ATP diphosphatase activity
ND444_10775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND444_10785	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND444_10790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND444_10795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND444_10800	COG1253	flavin adenine dinucleotide binding
ND444_10805	COG3069	C4-dicarboxylate transmembrane transporter activity
ND444_10810	COG2982	Protein involved in outer membrane biogenesis
ND444_10815	COG0717	Belongs to the dCTP deaminase family
ND444_10820	COG0572	uridine kinase
ND444_10825	COG0489	protein tyrosine kinase activity
ND444_10830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND444_10830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND444_10840	COG1380	Effector of murein hydrolase LrgA
ND444_10845	COG1346	cytolysis
ND444_10855	COG0583	DNA-binding transcription factor activity
ND444_10865	COG0281	malic enzyme
ND444_10870	COG2949	membrane
ND444_10895	COG2311	Membrane
ND444_10900	COG0302	gtp cyclohydrolase
ND444_10905	COG0477	Major facilitator Superfamily
ND444_10910	COG0583	DNA-binding transcription factor activity
ND444_10930	COG0303	'Molybdopterin
ND444_10935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND444_10940	COG0488	(ABC) transporter
ND444_10945	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND444_10950	COG2239	Acts as a magnesium transporter
ND444_10955	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND444_10975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND444_10980	COG0765	amino acid transport
ND444_10985	COG1126	abc transporter atp-binding protein
ND444_10990	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND444_10995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND444_11010	COG0697	spore germination
ND444_11020	COG1982	Orn Lys Arg decarboxylase major
ND444_11025	COG0531	amino acid
ND444_11030	COG1174	glycine betaine transport
ND444_11035	COG1125	glycine betaine transport
ND444_11040	COG1174	glycine betaine transport
ND444_11045	COG1732	Glycine betaine
ND444_11050	COG2897	thiosulfate sulfurtransferase activity
ND444_11055	COG4807	Protein conserved in bacteria
ND444_11060	COG3639	organic phosphonate transmembrane transporter activity
ND444_11070	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND444_11080	COG2261	transglycosylase associated protein
ND444_11100	COG0277	FAD linked oxidase domain protein
ND444_11105	COG1686	Belongs to the peptidase S11 family
ND444_11115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND444_11120	COG0513	Belongs to the DEAD box helicase family
ND444_11125	COG1309	transcriptional regulator
ND444_11130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND444_11135	COG1131	(ABC) transporter
ND444_11140	COG0842	Transport permease protein
ND444_11145	COG0842	Transport permease protein
ND444_11150	COG0670	Belongs to the BI1 family
ND444_11155	COG0314	molybdopterin synthase activity
ND444_11160	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND444_11170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND444_11175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND444_11180	COG1120	ATPase activity
ND444_11185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND444_11200	COG4628	conserved protein (DUF2132)
ND444_11205	COG0556	nucleotide-excision repair
ND444_11220	COG2226	methyltransferase
ND444_11225	COG0156	8-amino-7-oxononanoate synthase activity
ND444_11240	COG2706	6-phosphogluconolactonase activity
ND444_11245	COG0561	phosphatase activity
ND444_11255	COG4149	molybdate abc transporter
ND444_11260	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND444_11270	COG2005	Transcriptional regulator
ND444_11270	COG3585	molybdate ion transport
ND444_11285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND444_11290	COG1085	galactose-1-phosphate uridylyltransferase
ND444_11300	COG2017	converts alpha-aldose to the beta-anomer
ND444_11310	COG0588	phosphoglycerate mutase activity
ND444_11315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND444_11325	COG2205	protein histidine kinase activity
ND444_11325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND444_11335	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND444_11365	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND444_11370	COG2885	chlorophyll binding
ND444_11375	COG0823	Involved in the tonB-independent uptake of proteins
ND444_11380	COG3064	Membrane
ND444_11380	COG3064	Membrane
ND444_11385	COG0848	biopolymer transport protein
ND444_11390	COG0811	peptide transport
ND444_11395	COG0824	Thioesterase
ND444_11400	COG3790	cyd operon protein YbgE
ND444_11405	COG4890	Cyd operon protein YbgT
ND444_11410	COG1294	oxidase, subunit
ND444_11415	COG1271	oxidase subunit
ND444_11420	COG0737	Belongs to the 5'-nucleotidase family
ND444_11425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND444_11430	COG0045	succinate-CoA ligase (ADP-forming) activity
ND444_11435	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND444_11440	COG0567	Dehydrogenase, E1 component
ND444_11445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND444_11450	COG1053	succinate dehydrogenase
ND444_11455	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND444_11490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND444_11495	COG1984	allophanate hydrolase subunit 2
ND444_11500	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND444_11505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND444_11510	COG5212	phosphodiesterase
ND444_11515	COG0415	Belongs to the DNA photolyase family
ND444_11520	COG3272	Protein of unknown function (DUF1722)
ND444_11540	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND444_11545	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND444_11550	COG2205	protein histidine kinase activity
ND444_11555	COG0745	RESPONSE REGULATOR receiver
ND444_11565	COG0033	Phosphoglucomutase
ND444_11570	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND444_11575	COG0596	Alpha beta hydrolase
ND444_11585	COG0840	transmembrane signaling receptor activity
ND444_11595	COG0735	belongs to the Fur family
ND444_11620	COG1263	PTS System
ND444_11620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND444_11620	COG2190	(PTS) system
ND444_11630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND444_11635	COG1846	Transcriptional regulator
ND444_11635	COG1940	carbohydrate kinase activity
ND444_11640	COG0647	UMP catabolic process
ND444_11645	COG0367	asparagine synthase
ND444_11680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND444_11685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND444_11690	COG1702	phosphate starvation-inducible protein PhoH
ND444_11695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND444_11700	COG4535	Mg2 and Co2 transporter CorC
ND444_11705	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND444_11715	COG0765	amino acid transport
ND444_11720	COG0765	amino acid transport
ND444_11725	COG1126	abc transporter atp-binding protein
ND444_11730	COG2888	peptidyl-tyrosine sulfation
ND444_11740	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND444_11745	COG1466	dna polymerase III delta subunit
ND444_11750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND444_11755	COG0799	negative regulation of ribosome biogenesis
ND444_11760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND444_11765	COG0768	penicillin binding
ND444_11770	COG0772	Belongs to the SEDS family
ND444_11775	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND444_11780	COG1686	Belongs to the peptidase S11 family
ND444_11785	COG2921	Belongs to the UPF0250 family
ND444_11795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND444_11805	COG3706	GGDEF domain
ND444_11825	COG1278	Cold shock
ND444_11830	COG2197	response regulator
ND444_11855	COG1309	transcriptional regulator
ND444_11870	COG3250	beta-galactosidase activity
ND444_11890	COG1215	transferase activity, transferring glycosyl groups
ND444_11900	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND444_11930	COG3038	cytochrome b561
ND444_11955	COG1022	Amp-dependent synthetase and ligase
ND444_11965	COG1393	Belongs to the ArsC family
ND444_11970	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND444_11985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND444_11990	COG2501	S4 domain
ND444_12020	COG3121	Chaperone
ND444_12025	COG3188	usher protein
ND444_12050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND444_12055	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND444_12060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND444_12065	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND444_12070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND444_12075	COG4181	ATPase activity
ND444_12080	COG2755	lipolytic protein G-D-S-L family
ND444_12085	COG0300	oxidoreductase activity
ND444_12090	COG3118	belongs to the thioredoxin family
ND444_12095	COG0330	HflC and HflK could
ND444_12100	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND444_12105	COG0789	Transcriptional regulator
ND444_12110	COG2217	Heavy metal translocating P-type atpase
ND444_12115	COG3735	TraB family
ND444_12120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND444_12125	COG0737	Belongs to the 5'-nucleotidase family
ND444_12130	COG4651	solute:proton antiporter activity
ND444_12130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND444_12135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND444_12140	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND444_12155	COG0326	Molecular chaperone. Has ATPase activity
ND444_12160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND444_12200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND444_12205	COG2832	Protein of unknown function (DUF454)
ND444_12220	COG1196	nuclear chromosome segregation
ND444_12220	COG3264	Mechanosensitive ion channel
ND444_12225	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND444_12230	COG1309	transcriptional regulator
ND444_12235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND444_12240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND444_12245	COG0254	rRNA binding
ND444_12250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND444_12275	COG3695	enzyme binding
ND444_12280	COG1946	Acyl-CoA thioesterase
ND444_12285	COG0004	ammonium transporteR
ND444_12290	COG0347	Belongs to the P(II) protein family
ND444_12295	COG1132	(ABC) transporter
ND444_12300	COG1132	(ABC) transporter
ND444_12305	COG1522	sequence-specific DNA binding
ND444_12320	COG4533	DNA binding
ND444_12325	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND444_12330	COG0824	Thioesterase
ND444_12335	COG1555	photosystem II stabilization
ND444_12340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND444_12345	COG0776	regulation of translation
ND444_12350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND444_12355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND444_12360	COG0740	serine-type endopeptidase activity
ND444_12370	COG0271	Belongs to the BolA IbaG family
ND444_12375	COG3056	Lipoprotein
ND444_12380	COG2223	nitrite transmembrane transporter activity
ND444_12390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND444_12395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND444_12400	COG1845	cytochrome c oxidase, subunit III
ND444_12405	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND444_12415	COG2814	Major facilitator Superfamily
ND444_12420	COG1666	GTP binding
ND444_12425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND444_12430	COG0693	protein deglycase activity
ND444_12465	COG0142	geranyltranstransferase activity
ND444_12470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND444_12475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND444_12480	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND444_12490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND444_12495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND444_12495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND444_12500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND444_12505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND444_12510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND444_12515	COG1862	Preprotein translocase
ND444_12530	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND444_12535	COG0450	alkyl hydroperoxide reductase
ND444_12540	COG0300	oxidoreductase activity
ND444_12545	COG0366	Alpha amylase catalytic
ND444_12550	COG1113	amino acid transport
ND444_12565	COG5002	protein histidine kinase activity
ND444_12570	COG0745	RESPONSE REGULATOR receiver
ND444_12575	COG0420	3'-5' exonuclease activity
ND444_12580	COG0419	ATPase involved in DNA repair
ND444_12585	COG1940	carbohydrate kinase activity
ND444_12590	COG2974	May be involved in recombination
ND444_12600	COG4126	flavin adenine dinucleotide binding
ND444_12620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND444_12655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND444_12670	COG1073	alpha beta
ND444_12675	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND444_12680	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND444_12685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND444_12695	COG2991	Protein conserved in bacteria
ND444_12700	COG1477	protein flavinylation
ND444_12710	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND444_12715	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND444_12720	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND444_12725	COG1805	sodium ion transport
ND444_12735	COG3034	peptidoglycan biosynthetic process
ND444_12740	COG0121	glutamine amidotransferase
ND444_12745	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND444_12750	COG1960	acyl-CoA dehydrogenase activity
ND444_12760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND444_12770	COG2226	methyltransferase
ND444_12780	COG0741	lytic transglycosylase activity
ND444_12780	COG1388	LysM domain
ND444_12785	COG3021	interspecies interaction between organisms
ND444_12815	COG0542	response to heat
ND444_12820	COG1496	oxidoreductase activity
ND444_12825	COG0564	pseudouridine synthase activity
ND444_12830	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND444_12835	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND444_12845	COG1605	Chorismate mutase
ND444_12845	COG0077	Prephenate dehydratase
ND444_12850	COG0287	Prephenate dehydrogenase
ND444_12850	COG1605	Chorismate mutase
ND444_12855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND444_12860	COG3279	Response regulator of the LytR AlgR family
ND444_12865	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND444_12870	COG3137	Salt-induced outer membrane protein
ND444_12875	COG0335	large ribosomal subunit rRNA binding
ND444_12880	COG0336	Belongs to the RNA methyltransferase TrmD family
ND444_12885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND444_12895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND444_12900	COG4137	Cytochrome C assembly protein
ND444_12905	COG4536	flavin adenine dinucleotide binding
ND444_12910	COG1854	S-ribosylhomocysteine lyase activity
ND444_12915	COG2918	glutathione biosynthetic process
ND444_12920	COG1238	metal cluster binding
ND444_12925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND444_12955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND444_12960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND444_12965	COG2137	regulation of response to DNA damage stimulus
ND444_12970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND444_12985	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND444_12985	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND444_13050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND444_13055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND444_13060	COG4942	peptidase
ND444_13060	COG1388	LysM domain
ND444_13070	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND444_13075	COG0585	pseudouridine synthase activity
ND444_13080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND444_13090	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND444_13100	COG0529	Catalyzes the synthesis of activated sulfate
ND444_13105	COG2895	sulfate adenylyltransferase (ATP) activity
ND444_13110	COG0175	sulfate reduction
ND444_13115	COG1648	precorrin-2 dehydrogenase activity
ND444_13115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND444_13120	COG2234	aminopeptidase activity
ND444_13135	COG0175	sulfate reduction
ND444_13145	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND444_13150	COG0720	synthase
ND444_13155	COG0602	queuosine metabolic process
ND444_13165	COG0504	CTP synthase activity
ND444_13170	COG3956	TIGRFAM MazG family protein
ND444_13175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND444_13180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND444_13190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND444_13195	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND444_13200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND444_13210	COG2860	membrane
ND444_13215	COG0316	Belongs to the HesB IscA family
ND444_13225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND444_13230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND444_13235	COG1643	Atp-dependent helicase
ND444_13240	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND444_13245	COG1489	DNA binding
ND444_13260	COG0617	tRNA 3'-terminal CCA addition
ND444_13265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND444_13270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND444_13275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND444_13280	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND444_13285	COG0726	polysaccharide deacetylase
ND444_13290	COG0842	Transport permease protein
ND444_13295	COG1131	(ABC) transporter
ND444_13300	COG0288	reversible hydration of carbon dioxide
ND444_13310	COG2132	Multicopper oxidase
ND444_13320	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND444_13335	COG3112	Uncharacterised protein family (UPF0231)
ND444_13340	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND444_13350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND444_13355	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND444_13360	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND444_13365	COG2186	Transcriptional regulator
ND444_13370	COG1113	amino acid transport
ND444_13380	COG3725	Membrane protein required for beta-lactamase induction
ND444_13395	COG4969	Belongs to the N-Me-Phe pilin family
ND444_13400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND444_13405	COG1459	type II secretion system
ND444_13410	COG0516	GMP reductase activity
ND444_13430	COG0494	nUDIX hydrolase
ND444_13455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND444_13460	COG0849	cell division
ND444_13465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND444_13475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND444_13480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND444_13485	COG0772	Belongs to the SEDS family
ND444_13500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND444_13505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND444_13510	COG0768	penicillin binding
ND444_13515	COG3116	cell division
ND444_13520	COG0275	rRNA processing
ND444_13545	COG0028	Belongs to the TPP enzyme family
ND444_13550	COG1022	Amp-dependent synthetase and ligase
ND444_13565	COG0473	3-isopropylmalate dehydrogenase activity
ND444_13570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND444_13580	COG2814	Major facilitator Superfamily
ND444_13595	COG4143	(ABC) transporter
ND444_13600	COG1178	ABC-type Fe3 transport system permease component
ND444_13610	COG0586	Pfam SNARE associated Golgi protein
ND444_13615	COG0417	DNA replication proofreading
ND444_13620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND444_13625	COG0564	pseudouridine synthase activity
ND444_13635	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND444_13645	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND444_13650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND444_13655	COG2967	ApaG domain
ND444_13680	COG2966	Psort location CytoplasmicMembrane, score
ND444_13690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND444_13705	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND444_13710	COG1047	Peptidyl-prolyl cis-trans
ND444_13715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND444_13725	COG0196	riboflavin kinase activity
ND444_13735	COG0583	DNA-binding transcription factor activity
ND444_13740	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND444_13750	COG0443	Heat shock 70 kDa protein
ND444_13755	COG1584	GPR1 FUN34 yaaH family protein
ND444_13765	COG0477	Major facilitator Superfamily
ND444_13770	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND444_13775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND444_13810	COG0745	RESPONSE REGULATOR receiver
ND444_13815	COG3045	CreA protein
ND444_13820	COG2207	Transcriptional regulator
ND444_13820	COG3708	Transcriptional regulator
ND444_13825	COG0406	alpha-ribazole phosphatase activity
ND444_13830	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND444_13835	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND444_13840	COG0741	lytic transglycosylase activity
ND444_13860	COG0488	(ABC) transporter
ND444_13875	COG0560	Phosphoserine phosphatase
ND444_13880	COG3726	membrane protein affecting hemolysin expression
ND444_13890	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND444_13905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND444_13910	COG0084	hydrolase, TatD family'
ND444_13915	COG4667	esterase of the alpha-beta hydrolase superfamily
ND444_13925	COG2823	Periplasmic or secreted lipoprotein
ND444_13940	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND444_13980	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND444_13980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND444_13980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND444_13985	COG1461	Dihydroxyacetone kinase
ND444_13990	COG2376	Dihydroxyacetone kinase
ND444_14000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND444_14005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND444_14020	COG0859	PFAM glycosyl transferase family 9
ND444_14045	COG3119	arylsulfatase activity
ND444_14050	COG0641	radical SAM
ND444_14060	COG1028	Short-chain dehydrogenase reductase Sdr
ND444_14070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND444_14080	COG3716	PTS system mannose fructose sorbose family IID component
ND444_14085	COG3715	PTS system
ND444_14090	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND444_14095	COG2222	sugar isomerase
ND444_14105	COG1349	DNA-binding transcription factor activity
ND444_14110	COG3119	arylsulfatase activity
ND444_14130	COG5492	domain, Protein
ND444_14220	COG3077	Addiction module antitoxin, RelB DinJ family
ND444_14235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ND444_14280	COG0582	viral genome integration into host DNA
ND444_14290	COG0795	lipopolysaccharide-transporting ATPase activity
ND444_14295	COG0795	lipopolysaccharide-transporting ATPase activity
ND444_14300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND444_14305	COG2927	DNA polymerase III (CHI subunit)
ND444_14320	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND444_14340	COG3624	Phosphonate C-P lyase system protein PhnG
ND444_14345	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND444_14350	COG3626	phosphonate metabolism
ND444_14355	COG3627	carbon phosphorus lyase activity
ND444_14360	COG4107	phosphonate C-P lyase system protein PhnK
ND444_14365	COG4778	phosphonate C-P lyase system protein PhnL
ND444_14370	COG3454	Phosphonate metabolism
ND444_14375	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND444_14380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND444_14385	COG0702	epimerase
ND444_14390	COG3787	Belongs to the UPF0306 family
ND444_14400	COG1982	Orn Lys Arg decarboxylase major
ND444_14405	COG0531	amino acid
ND444_14410	COG2827	Endonuclease containing a URI domain
ND444_14415	COG3153	acetyltransferase
ND444_14420	COG3154	lipid carrier protein
ND444_14425	COG0826	peptidase U32
ND444_14430	COG0826	peptidase U32
ND444_14440	COG0814	amino acid
ND444_14445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND444_14450	COG0513	Belongs to the DEAD box helicase family
ND444_14460	COG1185	polyribonucleotide nucleotidyltransferase activity
ND444_14475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND444_14485	COG0195	Participates in both transcription termination and antitermination
ND444_14505	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND444_14510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND444_14515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND444_14525	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND444_14530	COG1534	Rna-binding protein
ND444_14540	COG2027	D-alanyl-D-alanine carboxypeptidase
ND444_14545	COG0745	RESPONSE REGULATOR receiver
ND444_14550	COG0642	Histidine kinase
ND444_14555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND444_14560	COG0697	spore germination
ND444_14575	COG0142	geranyltranstransferase activity
ND444_14590	COG3423	Transcriptional regulator
ND444_14605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND444_14615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND444_14620	COG2105	PFAM AIG2 family protein
ND444_14625	COG2911	Protein conserved in bacteria
ND444_14630	COG0729	surface antigen
ND444_14635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND444_14640	COG1253	flavin adenine dinucleotide binding
ND444_14650	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND444_14655	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND444_14660	COG0737	Belongs to the 5'-nucleotidase family
ND444_14670	COG0545	Peptidyl-prolyl cis-trans isomerase
ND444_14675	COG3061	Opacity-associated protein A
ND444_14680	COG0359	binds to the 23S rRNA
ND444_14685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND444_14690	COG2965	DNA replication, synthesis of RNA primer
ND444_14695	COG0360	Binds together with S18 to 16S ribosomal RNA
ND444_14705	COG1073	alpha beta
ND444_14725	COG3188	usher protein
ND444_14730	COG3121	Chaperone
ND444_14750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND444_14755	COG0557	exoribonuclease II activity
ND444_14760	COG1959	2 iron, 2 sulfur cluster binding
ND444_14765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND444_14770	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND444_14775	COG0330	HflC and HflK could
ND444_14780	COG0330	HflC and HflK could
ND444_14785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND444_14795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND444_14805	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND444_14810	COG0802	atpase or kinase
ND444_14815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND444_14815	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND444_14820	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND444_14840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND444_14845	COG1162	GTPase activity
ND444_14850	COG0688	phosphatidylethanolamine metabolic process
ND444_14855	COG1511	domain protein
ND444_14855	COG3264	Mechanosensitive ion channel
ND444_14860	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND444_14865	COG1053	succinate dehydrogenase
ND444_14870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND444_14875	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND444_14880	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND444_14900	COG3188	usher protein
ND444_14920	COG3397	chitin binding
ND444_14930	COG1509	lysine 2,3-aminomutase activity
ND444_14960	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND444_14970	COG4232	protein-disulfide reductase activity
ND444_14975	COG1309	transcriptional regulator
ND444_14995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND444_15015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ND444_15020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND444_15020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND444_15040	COG1028	Short-chain dehydrogenase reductase Sdr
ND444_15045	COG2755	lipolytic protein G-D-S-L family
ND444_15045	COG1083	cytidylyl-transferase
ND444_15065	COG2089	acid synthase
ND444_15070	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND444_15075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND444_15085	COG0425	Belongs to the sulfur carrier protein TusA family
ND444_15090	COG2391	methyltransferase activity
ND444_15095	COG1301	dicarboxylic acid transport
ND444_15100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND444_15105	COG3162	membrane
ND444_15135	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND444_15140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND444_15145	COG1739	Uncharacterized protein family UPF0029
ND444_15155	COG1024	Enoyl-CoA hydratase
ND444_15155	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND444_15165	COG0543	2 iron, 2 sulfur cluster binding
ND444_15180	COG0250	Participates in transcription elongation, termination and antitermination
ND444_15195	COG0805	protein transport
ND444_15200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND444_15205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND444_15210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND444_15215	COG3165	ubiquinone biosynthetic process from chorismate
ND444_15220	COG2226	methyltransferase
ND444_15225	COG1322	Protein conserved in bacteria
ND444_15230	COG0586	Pfam SNARE associated Golgi protein
ND444_15235	COG1966	Carbon starvation protein
ND444_15250	COG0412	Dienelactone hydrolase
ND444_15255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND444_15260	COG0583	DNA-binding transcription factor activity
ND444_15265	COG0697	spore germination
ND444_15275	COG0584	glycerophosphoryl diester phosphodiesterase
ND444_15285	COG0395	ABC-type sugar transport system, permease component
ND444_15290	COG1175	transmembrane transport
ND444_15295	COG1653	transport
ND444_15335	COG0410	ABC transporter
ND444_15345	COG4177	L-phenylalanine transmembrane transporter activity
ND444_15365	COG1929	Belongs to the glycerate kinase type-1 family
ND444_15370	COG2610	gluconate transmembrane transporter activity
ND444_15375	COG3835	regulator
ND444_15385	COG2177	Part of the ABC transporter FtsEX involved in
ND444_15390	COG2884	Cell division ATP-binding protein ftsE
ND444_15395	COG0552	protein localization to endoplasmic reticulum
ND444_15395	COG0552	protein localization to endoplasmic reticulum
ND444_15400	COG0742	ribosomal rna small subunit methyltransferase
ND444_15405	COG3776	membrane
ND444_15420	COG3714	YhhN family
ND444_15435	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND444_15445	COG0247	lactate metabolic process
ND444_15455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND444_15465	COG2271	Major facilitator Superfamily
ND444_15470	COG0584	glycerophosphoryl diester phosphodiesterase
ND444_15475	COG0561	phosphatase activity
ND444_15480	COG2267	carboxylic ester hydrolase activity
ND444_15485	COG1280	lysine exporter protein (LysE YggA)
ND444_15490	COG0514	ATP-dependent DNA helicase (RecQ)
ND444_15495	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND444_15500	COG2050	protein possibly involved in aromatic compounds catabolism
ND444_15520	COG5564	TIM-barrel signal transduction protein
ND444_15525	COG5441	Belongs to the UPF0261 family
ND444_15535	COG0210	DNA helicase
ND444_15540	COG1011	Hydrolase
ND444_15545	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND444_15550	COG3159	Protein conserved in bacteria
ND444_15555	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND444_15560	COG5567	small periplasmic lipoprotein
ND444_15570	COG3072	Adenylate cyclase
ND444_15575	COG0181	hydroxymethylbilane synthase activity
ND444_15580	COG1587	Uroporphyrinogen-III synthase
ND444_15585	COG2959	enzyme of heme biosynthesis
ND444_15590	COG3071	HemY protein
ND444_15640	COG2244	polysaccharide biosynthetic process
ND444_15645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND444_15650	COG0456	acetyltransferase
ND444_15655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND444_15660	COG1088	dTDP-glucose 4,6-dehydratase activity
ND444_15665	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND444_15670	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND444_15675	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND444_15680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND444_15685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND444_15690	COG3118	belongs to the thioredoxin family
ND444_15700	COG0248	Ppx GppA phosphatase
ND444_15710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND444_15725	COG3397	chitin binding
ND444_15735	COG0129	dihydroxy-acid dehydratase activity
ND444_15745	COG3978	acetolactate synthase activity
ND444_15765	COG3085	chromosome segregation
ND444_15770	COG0583	DNA-binding transcription factor activity
ND444_15850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND444_15860	COG0678	peroxiredoxin activity
ND444_15860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND444_15865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND444_15900	COG1629	transport
ND444_15905	COG0165	Argininosuccinate lyase
ND444_15910	COG0137	argininosuccinate synthase activity
ND444_15915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND444_15965	COG0460	homoserine dehydrogenase
ND444_15965	COG0527	aspartate kinase activity
ND444_15970	COG0626	cystathionine gamma-synthase activity
ND444_15975	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND444_15985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND444_15990	COG1609	Transcriptional regulator
ND444_15995	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND444_16000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND444_16005	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND444_16010	COG1575	Belongs to the MenA family. Type 1 subfamily
ND444_16015	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND444_16020	COG3074	FtsZ-dependent cytokinesis
ND444_16025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND444_16030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND444_16035	COG1494	fructose-1,6-bisphosphatase
ND444_16040	COG2814	Major facilitator Superfamily
ND444_16050	COG3152	Membrane
ND444_16065	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND444_16075	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND444_16120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ND444_16210	COG4695	Portal protein
ND444_16290	COG3678	ATP-independent chaperone mediated protein folding
ND444_16295	COG0745	RESPONSE REGULATOR receiver
ND444_16300	COG2205	protein histidine kinase activity
ND444_16305	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND444_16310	COG1045	serine acetyltransferase
ND444_16315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND444_16320	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND444_16325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND444_16330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND444_16335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND444_16340	COG4942	peptidase
ND444_16345	COG2861	carbohydrate metabolic process
ND444_16360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND444_16365	COG0859	PFAM glycosyl transferase family 9
ND444_16370	COG0859	PFAM glycosyl transferase family 9
ND444_16375	COG1519	Transferase
ND444_16395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND444_16400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND444_16405	COG2003	Belongs to the UPF0758 family
ND444_16410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND444_16415	COG0756	dUTP diphosphatase activity
ND444_16420	COG1309	transcriptional regulator
ND444_16425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND444_16430	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND444_16435	COG1561	YicC-like family, N-terminal region
ND444_16475	COG5001	Diguanylate cyclase
ND444_16480	COG1024	Enoyl-CoA hydratase
ND444_16485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND444_16495	COG2860	membrane
ND444_16500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND444_16510	COG1758	RNA polymerase activity
ND444_16515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND444_16520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND444_16525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND444_16530	COG0786	glutamate:sodium symporter activity
ND444_16535	COG2233	PERMEase
ND444_16540	COG2982	Protein involved in outer membrane biogenesis
ND444_16545	COG0456	acetyltransferase
ND444_16560	COG1011	Hydrolase
ND444_16575	COG3852	Histidine kinase
ND444_16585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND444_16595	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND444_16600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND444_16600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND444_16605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND444_16610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND444_16615	COG3084	Protein conserved in bacteria
ND444_16625	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND444_16650	COG2186	Transcriptional regulator
ND444_16655	COG1609	Transcriptional regulator
ND444_16660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND444_16670	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND444_16675	COG1129	ABC transporter
ND444_16680	COG1869	D-ribose catabolic process
ND444_16685	COG3158	transport of potassium into the cell
ND444_16690	COG0714	Associated with various cellular activities
ND444_16695	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND444_16705	COG2502	aspartate--ammonia ligase
ND444_16710	COG1522	sequence-specific DNA binding
ND444_16715	COG0716	FMN binding
ND444_16720	COG0445	tRNA wobble uridine modification
ND444_16725	COG0357	Ribosomal RNA small subunit methyltransferase G
ND444_16730	COG3312	ion transport
ND444_16735	COG0356	it plays a direct role in the translocation of protons across the membrane
ND444_16745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND444_16755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND444_16760	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND444_16770	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND444_16785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND444_16790	COG0573	inorganic phosphate transmembrane transporter activity
ND444_16795	COG0581	inorganic phosphate transmembrane transporter activity
ND444_16805	COG0704	Plays a role in the regulation of phosphate uptake
ND444_16810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND444_16815	COG0765	amino acid transport
ND444_16820	COG0765	amino acid transport
ND444_16825	COG2252	PERMEase
ND444_16830	COG0840	transmembrane signaling receptor activity
ND444_16840	COG3121	Chaperone
ND444_16855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND444_16860	COG0706	membrane insertase activity
ND444_16870	COG0594	ribonuclease P activity
ND444_16875	COG0230	Belongs to the bacterial ribosomal protein bL34 family