locus-tag	class	description
ND439_00010	COG0592	DNA-directed DNA polymerase activity
ND439_00020	COG0187	DNA topoisomerase II activity
ND439_00025	COG0561	phosphatase activity
ND439_00030	COG0823	Involved in the tonB-independent uptake of proteins
ND439_00035	COG5645	(Lipo)protein
ND439_00050	COG0569	domain protein
ND439_00050	COG2985	domain, Protein
ND439_00055	COG3977	Valine--pyruvate aminotransferase
ND439_00060	COG2885	chlorophyll binding
ND439_00080	COG2818	Glycosylase
ND439_00135	COG2213	PTS system mannitol-specific
ND439_00135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND439_00145	COG3722	fumarate hydratase activity
ND439_00155	COG2258	MOSC domain
ND439_00160	COG0840	transmembrane signaling receptor activity
ND439_00165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND439_00180	COG0437	4 iron, 4 sulfur cluster binding
ND439_00185	COG2864	formate dehydrogenase
ND439_00195	COG1921	L-seryl-tRNASec selenium transferase activity
ND439_00200	COG3276	selenocysteine insertion sequence binding
ND439_00205	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND439_00215	COG3274	enterobacterial common antigen metabolic process
ND439_00250	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND439_00255	COG2986	histidine ammonia-lyase
ND439_00275	COG2194	sulfuric ester hydrolase activity
ND439_00280	COG2197	response regulator
ND439_00285	COG3851	Histidine kinase
ND439_00290	COG2271	Major facilitator Superfamily
ND439_00300	COG0747	negative chemotaxis
ND439_00305	COG0601	transmembrane transport
ND439_00310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND439_00315	COG0444	Belongs to the ABC transporter superfamily
ND439_00320	COG4608	Belongs to the ABC transporter superfamily
ND439_00325	COG2194	sulfuric ester hydrolase activity
ND439_00350	COG1215	transferase activity, transferring glycosyl groups
ND439_00355	COG1215	transferase activity, transferring glycosyl groups
ND439_00360	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND439_00365	COG0457	Tetratricopeptide repeat
ND439_00365	COG3118	belongs to the thioredoxin family
ND439_00370	COG2200	EAL domain
ND439_00370	COG2199	diguanylate cyclase activity
ND439_00375	COG1301	dicarboxylic acid transport
ND439_00380	COG0612	Peptidase, M16
ND439_00385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND439_00390	COG1942	4-Oxalocrotonate Tautomerase
ND439_00395	COG2200	EAL domain
ND439_00400	COG2134	cdp-diacylglycerol pyrophosphatase
ND439_00405	COG1295	ribonuclease BN
ND439_00415	COG1301	dicarboxylic acid transport
ND439_00420	COG0626	cystathionine gamma-synthase activity
ND439_00435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND439_00440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND439_00445	COG0339	signal peptide processing
ND439_00450	COG0742	ribosomal rna small subunit methyltransferase
ND439_00460	COG0589	response to stress
ND439_00470	COG0306	phosphate transporter
ND439_00475	COG2081	HI0933 family
ND439_00485	COG1247	-acetyltransferase
ND439_00490	COG1741	Belongs to the pirin family
ND439_00495	COG1609	Transcriptional regulator
ND439_00500	COG2610	gluconate transmembrane transporter activity
ND439_00505	COG3265	gluconokinase activity
ND439_00510	COG2095	MarC family integral membrane protein
ND439_00515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND439_00520	COG3275	phosphorelay sensor kinase activity
ND439_00525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND439_00530	COG1523	belongs to the glycosyl hydrolase 13 family
ND439_00535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND439_00540	COG0297	glycogen (starch) synthase activity
ND439_00545	COG0058	SHG alpha-glucan phosphorylase activity
ND439_00550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND439_00555	COG1349	DNA-binding transcription factor activity
ND439_00560	COG0705	Rhomboid family
ND439_00570	COG2909	trisaccharide binding
ND439_00575	COG0058	SHG alpha-glucan phosphorylase activity
ND439_00580	COG1640	4-alpha-glucanotransferase
ND439_00590	COG1040	competence protein
ND439_00595	COG0596	Alpha beta hydrolase
ND439_00615	COG1918	ferrous iron import across plasma membrane
ND439_00620	COG2183	response to ionizing radiation
ND439_00645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND439_00660	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND439_00670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND439_00675	COG1011	Hydrolase
ND439_00685	COG0494	nUDIX hydrolase
ND439_00690	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND439_00715	COG4796	Type ii and iii secretion system protein
ND439_00720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND439_00740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND439_00750	COG0180	Tryptophanyl-tRNA synthetase
ND439_00770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND439_00775	COG0402	S-adenosylhomocysteine deaminase activity
ND439_00780	COG0738	Major facilitator superfamily
ND439_00795	COG1609	Transcriptional regulator
ND439_00800	COG1486	melibiose metabolic process
ND439_00805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND439_00820	COG1289	transmembrane transporter activity
ND439_00825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND439_00830	COG1765	OsmC-like protein
ND439_00855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND439_00860	COG3954	Phosphoribulokinase
ND439_00870	COG0429	hydrolase of the alpha beta-hydrolase fold
ND439_00880	COG0859	PFAM glycosyl transferase family 9
ND439_00885	COG1216	Glycosyl transferase, family 2
ND439_00890	COG0488	(ABC) transporter
ND439_00895	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND439_00905	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND439_00910	COG1047	Peptidyl-prolyl cis-trans
ND439_00920	COG0545	Peptidyl-prolyl cis-trans isomerase
ND439_00925	COG2964	Protein conserved in bacteria
ND439_00935	COG2923	Belongs to the DsrF TusC family
ND439_00940	COG2168	tRNA wobble position uridine thiolation
ND439_00945	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND439_00950	COG0049	tRNA binding
ND439_00960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND439_00975	COG0051	transcription antitermination factor activity, RNA binding
ND439_00980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND439_00990	COG0089	rRNA binding
ND439_00995	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND439_01000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND439_01005	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND439_01015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND439_01020	COG0255	Belongs to the universal ribosomal protein uL29 family
ND439_01025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND439_01030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND439_01040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND439_01065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND439_01070	COG1841	ribosomal large subunit assembly
ND439_01075	COG0200	Binds to the 23S rRNA
ND439_01080	COG0201	protein transport
ND439_01085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND439_01090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND439_01100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND439_01110	COG0203	ribosomal protein L17
ND439_01115	COG0789	Transcriptional regulator
ND439_01120	COG3036	rescue of stalled ribosome
ND439_01125	COG1970	mechanosensitive ion channel activity
ND439_01135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND439_01135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND439_01140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND439_01145	COG0242	peptide deformylase activity
ND439_01150	COG0758	DNA mediated transformation
ND439_01155	COG2922	Belongs to the Smg family
ND439_01160	COG0551	DNA topoisomerase type I activity
ND439_01165	COG0009	L-threonylcarbamoyladenylate synthase
ND439_01175	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND439_01205	COG3162	membrane
ND439_01210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND439_01215	COG1301	dicarboxylic acid transport
ND439_01220	COG2391	methyltransferase activity
ND439_01225	COG0425	Belongs to the sulfur carrier protein TusA family
ND439_01235	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND439_01240	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND439_01245	COG2089	acid synthase
ND439_01265	COG2755	lipolytic protein G-D-S-L family
ND439_01265	COG1083	cytidylyl-transferase
ND439_01270	COG1028	Short-chain dehydrogenase reductase Sdr
ND439_01290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND439_01290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND439_01295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ND439_01315	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND439_01335	COG1309	transcriptional regulator
ND439_01340	COG4232	protein-disulfide reductase activity
ND439_01350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND439_01380	COG1509	lysine 2,3-aminomutase activity
ND439_01390	COG3397	chitin binding
ND439_01410	COG3188	usher protein
ND439_01430	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND439_01435	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND439_01440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND439_01445	COG1053	succinate dehydrogenase
ND439_01450	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND439_01455	COG3264	Mechanosensitive ion channel
ND439_01455	COG1511	domain protein
ND439_01460	COG0688	phosphatidylethanolamine metabolic process
ND439_01465	COG1162	GTPase activity
ND439_01470	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND439_01490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND439_01495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND439_01495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND439_01500	COG0802	atpase or kinase
ND439_01505	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND439_01515	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND439_01525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND439_01530	COG0330	HflC and HflK could
ND439_01535	COG0330	HflC and HflK could
ND439_01540	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND439_01545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND439_01550	COG1959	2 iron, 2 sulfur cluster binding
ND439_01555	COG0557	exoribonuclease II activity
ND439_01560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND439_01580	COG3121	Chaperone
ND439_01585	COG3188	usher protein
ND439_01605	COG1073	alpha beta
ND439_01615	COG0360	Binds together with S18 to 16S ribosomal RNA
ND439_01620	COG2965	DNA replication, synthesis of RNA primer
ND439_01625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND439_01630	COG0359	binds to the 23S rRNA
ND439_01635	COG3061	Opacity-associated protein A
ND439_01640	COG0545	Peptidyl-prolyl cis-trans isomerase
ND439_01650	COG0737	Belongs to the 5'-nucleotidase family
ND439_01655	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND439_01660	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND439_01670	COG1253	flavin adenine dinucleotide binding
ND439_01675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND439_01680	COG0729	surface antigen
ND439_01685	COG2911	Protein conserved in bacteria
ND439_01690	COG2105	PFAM AIG2 family protein
ND439_01695	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND439_01705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND439_01720	COG3423	Transcriptional regulator
ND439_01735	COG0142	geranyltranstransferase activity
ND439_01750	COG0697	spore germination
ND439_01755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND439_01760	COG0642	Histidine kinase
ND439_01765	COG0745	RESPONSE REGULATOR receiver
ND439_01770	COG2027	D-alanyl-D-alanine carboxypeptidase
ND439_01780	COG1534	Rna-binding protein
ND439_01785	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND439_01795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND439_01800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND439_01805	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND439_01825	COG0195	Participates in both transcription termination and antitermination
ND439_01835	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND439_01850	COG1185	polyribonucleotide nucleotidyltransferase activity
ND439_01860	COG0513	Belongs to the DEAD box helicase family
ND439_01865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND439_01870	COG0814	amino acid
ND439_01880	COG0826	peptidase U32
ND439_01885	COG0826	peptidase U32
ND439_01890	COG3154	lipid carrier protein
ND439_01895	COG3153	acetyltransferase
ND439_01900	COG2827	Endonuclease containing a URI domain
ND439_01905	COG0531	amino acid
ND439_01910	COG1982	Orn Lys Arg decarboxylase major
ND439_01920	COG3787	Belongs to the UPF0306 family
ND439_01925	COG0702	epimerase
ND439_01930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND439_01935	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND439_01940	COG3454	Phosphonate metabolism
ND439_01945	COG4778	phosphonate C-P lyase system protein PhnL
ND439_01950	COG4107	phosphonate C-P lyase system protein PhnK
ND439_01955	COG3627	carbon phosphorus lyase activity
ND439_01960	COG3626	phosphonate metabolism
ND439_01965	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND439_01970	COG3624	Phosphonate C-P lyase system protein PhnG
ND439_01995	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND439_02010	COG2927	DNA polymerase III (CHI subunit)
ND439_02015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND439_02020	COG0795	lipopolysaccharide-transporting ATPase activity
ND439_02025	COG0795	lipopolysaccharide-transporting ATPase activity
ND439_02035	COG0582	viral genome integration into host DNA
ND439_02055	COG0582	viral genome integration into host DNA
ND439_02150	COG5492	domain, Protein
ND439_02170	COG3119	arylsulfatase activity
ND439_02175	COG1349	DNA-binding transcription factor activity
ND439_02185	COG2222	sugar isomerase
ND439_02190	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND439_02195	COG3715	PTS system
ND439_02200	COG3716	PTS system mannose fructose sorbose family IID component
ND439_02210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND439_02220	COG1028	Short-chain dehydrogenase reductase Sdr
ND439_02230	COG0641	radical SAM
ND439_02235	COG3119	arylsulfatase activity
ND439_02260	COG0859	PFAM glycosyl transferase family 9
ND439_02275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND439_02280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND439_02290	COG2376	Dihydroxyacetone kinase
ND439_02295	COG1461	Dihydroxyacetone kinase
ND439_02300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND439_02300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND439_02300	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND439_02340	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND439_02355	COG2823	Periplasmic or secreted lipoprotein
ND439_02365	COG4667	esterase of the alpha-beta hydrolase superfamily
ND439_02370	COG0084	hydrolase, TatD family'
ND439_02375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND439_02390	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND439_02400	COG3726	membrane protein affecting hemolysin expression
ND439_02405	COG0560	Phosphoserine phosphatase
ND439_02420	COG0488	(ABC) transporter
ND439_02440	COG0741	lytic transglycosylase activity
ND439_02445	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND439_02450	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND439_02455	COG0406	alpha-ribazole phosphatase activity
ND439_02460	COG2207	Transcriptional regulator
ND439_02460	COG3708	Transcriptional regulator
ND439_02465	COG3045	CreA protein
ND439_02470	COG0745	RESPONSE REGULATOR receiver
ND439_02505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND439_02510	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND439_02515	COG0477	Major facilitator Superfamily
ND439_02525	COG1584	GPR1 FUN34 yaaH family protein
ND439_02530	COG0443	Heat shock 70 kDa protein
ND439_02540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND439_02545	COG0583	DNA-binding transcription factor activity
ND439_02555	COG0196	riboflavin kinase activity
ND439_02565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND439_02570	COG1047	Peptidyl-prolyl cis-trans
ND439_02575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND439_02590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND439_02600	COG2966	Psort location CytoplasmicMembrane, score
ND439_02625	COG2967	ApaG domain
ND439_02630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND439_02635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND439_02645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND439_02655	COG0564	pseudouridine synthase activity
ND439_02660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND439_02665	COG0417	DNA replication proofreading
ND439_02670	COG0586	Pfam SNARE associated Golgi protein
ND439_02680	COG1178	ABC-type Fe3 transport system permease component
ND439_02685	COG4143	(ABC) transporter
ND439_02700	COG2814	Major facilitator Superfamily
ND439_02710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND439_02715	COG0473	3-isopropylmalate dehydrogenase activity
ND439_02730	COG1022	Amp-dependent synthetase and ligase
ND439_02735	COG0028	Belongs to the TPP enzyme family
ND439_02760	COG0275	rRNA processing
ND439_02765	COG3116	cell division
ND439_02770	COG0768	penicillin binding
ND439_02775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND439_02780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND439_02795	COG0772	Belongs to the SEDS family
ND439_02800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND439_02805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND439_02815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND439_02820	COG0849	cell division
ND439_02825	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND439_02850	COG0494	nUDIX hydrolase
ND439_02870	COG0516	GMP reductase activity
ND439_02875	COG1459	type II secretion system
ND439_02880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND439_02885	COG4969	Belongs to the N-Me-Phe pilin family
ND439_02900	COG3725	Membrane protein required for beta-lactamase induction
ND439_02915	COG5492	domain, Protein
ND439_02920	COG1113	amino acid transport
ND439_02925	COG2186	Transcriptional regulator
ND439_02930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND439_02935	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND439_02940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND439_02950	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND439_02955	COG3112	Uncharacterised protein family (UPF0231)
ND439_02970	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND439_02980	COG2132	Multicopper oxidase
ND439_02990	COG0288	reversible hydration of carbon dioxide
ND439_02995	COG1131	(ABC) transporter
ND439_03000	COG0842	Transport permease protein
ND439_03005	COG0726	polysaccharide deacetylase
ND439_03010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND439_03015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND439_03020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND439_03025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND439_03030	COG0617	tRNA 3'-terminal CCA addition
ND439_03045	COG1489	DNA binding
ND439_03050	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND439_03055	COG1643	Atp-dependent helicase
ND439_03060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND439_03065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND439_03075	COG0316	Belongs to the HesB IscA family
ND439_03080	COG2860	membrane
ND439_03090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND439_03095	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND439_03100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND439_03110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND439_03115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND439_03120	COG3956	TIGRFAM MazG family protein
ND439_03125	COG0504	CTP synthase activity
ND439_03135	COG0602	queuosine metabolic process
ND439_03140	COG0720	synthase
ND439_03145	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND439_03155	COG0175	sulfate reduction
ND439_03170	COG2234	aminopeptidase activity
ND439_03175	COG1648	precorrin-2 dehydrogenase activity
ND439_03175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND439_03180	COG0175	sulfate reduction
ND439_03185	COG2895	sulfate adenylyltransferase (ATP) activity
ND439_03190	COG0529	Catalyzes the synthesis of activated sulfate
ND439_03200	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND439_03210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND439_03215	COG0585	pseudouridine synthase activity
ND439_03220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND439_03230	COG4942	peptidase
ND439_03230	COG1388	LysM domain
ND439_03235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND439_03240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND439_03310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND439_03330	COG3397	chitin binding
ND439_03340	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ND439_03385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND439_03395	COG3031	protein transport across the cell outer membrane
ND439_03420	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND439_03420	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND439_03435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND439_03440	COG2137	regulation of response to DNA damage stimulus
ND439_03445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND439_03450	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND439_03480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND439_03485	COG1238	metal cluster binding
ND439_03490	COG2918	glutathione biosynthetic process
ND439_03495	COG1854	S-ribosylhomocysteine lyase activity
ND439_03500	COG4536	flavin adenine dinucleotide binding
ND439_03505	COG4137	Cytochrome C assembly protein
ND439_03510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND439_03520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND439_03525	COG0336	Belongs to the RNA methyltransferase TrmD family
ND439_03530	COG0335	large ribosomal subunit rRNA binding
ND439_03535	COG3137	Salt-induced outer membrane protein
ND439_03540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND439_03545	COG3279	Response regulator of the LytR AlgR family
ND439_03550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND439_03555	COG0287	Prephenate dehydrogenase
ND439_03555	COG1605	Chorismate mutase
ND439_03560	COG1605	Chorismate mutase
ND439_03560	COG0077	Prephenate dehydratase
ND439_03570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND439_03575	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND439_03580	COG0564	pseudouridine synthase activity
ND439_03585	COG1496	oxidoreductase activity
ND439_03590	COG0542	response to heat
ND439_03620	COG3021	interspecies interaction between organisms
ND439_03625	COG1388	LysM domain
ND439_03625	COG0741	lytic transglycosylase activity
ND439_03635	COG2226	methyltransferase
ND439_03645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND439_03655	COG1960	acyl-CoA dehydrogenase activity
ND439_03660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND439_03665	COG0121	glutamine amidotransferase
ND439_03670	COG3034	peptidoglycan biosynthetic process
ND439_03680	COG1805	sodium ion transport
ND439_03685	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND439_03690	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND439_03695	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND439_03705	COG1477	protein flavinylation
ND439_03710	COG2991	Protein conserved in bacteria
ND439_03720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND439_03725	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND439_03730	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND439_03735	COG1073	alpha beta
ND439_03750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND439_03785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND439_03805	COG4126	flavin adenine dinucleotide binding
ND439_03815	COG2974	May be involved in recombination
ND439_03820	COG1940	carbohydrate kinase activity
ND439_03825	COG0419	ATPase involved in DNA repair
ND439_03830	COG0420	3'-5' exonuclease activity
ND439_03835	COG0745	RESPONSE REGULATOR receiver
ND439_03840	COG5002	protein histidine kinase activity
ND439_03855	COG1113	amino acid transport
ND439_03860	COG0366	Alpha amylase catalytic
ND439_03865	COG0300	oxidoreductase activity
ND439_03870	COG0450	alkyl hydroperoxide reductase
ND439_03875	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND439_03890	COG1862	Preprotein translocase
ND439_03895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND439_03900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND439_03905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND439_03910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND439_03910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND439_03915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND439_03925	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND439_03930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND439_03935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND439_03940	COG0142	geranyltranstransferase activity
ND439_03975	COG0693	protein deglycase activity
ND439_03980	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND439_03985	COG1666	GTP binding
ND439_03990	COG2814	Major facilitator Superfamily
ND439_04000	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND439_04005	COG1845	cytochrome c oxidase, subunit III
ND439_04010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND439_04015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND439_04025	COG2223	nitrite transmembrane transporter activity
ND439_04030	COG3056	Lipoprotein
ND439_04035	COG0271	Belongs to the BolA IbaG family
ND439_04045	COG0740	serine-type endopeptidase activity
ND439_04050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND439_04055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND439_04060	COG0776	regulation of translation
ND439_04065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND439_04070	COG1555	photosystem II stabilization
ND439_04075	COG0824	Thioesterase
ND439_04080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND439_04085	COG4533	DNA binding
ND439_04100	COG1522	sequence-specific DNA binding
ND439_04105	COG1132	(ABC) transporter
ND439_04110	COG1132	(ABC) transporter
ND439_04115	COG0347	Belongs to the P(II) protein family
ND439_04120	COG0004	ammonium transporteR
ND439_04125	COG1946	Acyl-CoA thioesterase
ND439_04130	COG3695	enzyme binding
ND439_04155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND439_04160	COG0254	rRNA binding
ND439_04165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND439_04170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND439_04175	COG1309	transcriptional regulator
ND439_04180	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND439_04185	COG1196	nuclear chromosome segregation
ND439_04185	COG3264	Mechanosensitive ion channel
ND439_04200	COG2832	Protein of unknown function (DUF454)
ND439_04205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND439_04245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND439_04250	COG0326	Molecular chaperone. Has ATPase activity
ND439_04265	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND439_04270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND439_04275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND439_04275	COG4651	solute:proton antiporter activity
ND439_04280	COG0737	Belongs to the 5'-nucleotidase family
ND439_04285	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND439_04290	COG3735	TraB family
ND439_04295	COG2217	Heavy metal translocating P-type atpase
ND439_04300	COG0789	Transcriptional regulator
ND439_04305	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND439_04310	COG0330	HflC and HflK could
ND439_04315	COG3118	belongs to the thioredoxin family
ND439_04320	COG0300	oxidoreductase activity
ND439_04325	COG2755	lipolytic protein G-D-S-L family
ND439_04330	COG4181	ATPase activity
ND439_04335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND439_04340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND439_04345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND439_04350	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND439_04355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND439_04380	COG3188	usher protein
ND439_04385	COG3121	Chaperone
ND439_04415	COG2501	S4 domain
ND439_04420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND439_04435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND439_04440	COG1393	Belongs to the ArsC family
ND439_04450	COG1022	Amp-dependent synthetase and ligase
ND439_04475	COG3038	cytochrome b561
ND439_04505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND439_04515	COG1215	transferase activity, transferring glycosyl groups
ND439_04535	COG3250	beta-galactosidase activity
ND439_04550	COG1309	transcriptional regulator
ND439_04575	COG2197	response regulator
ND439_04580	COG1278	Cold shock
ND439_04600	COG3706	GGDEF domain
ND439_04610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND439_04620	COG2921	Belongs to the UPF0250 family
ND439_04625	COG1686	Belongs to the peptidase S11 family
ND439_04630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND439_04635	COG0772	Belongs to the SEDS family
ND439_04640	COG0768	penicillin binding
ND439_04645	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND439_04650	COG0799	negative regulation of ribosome biogenesis
ND439_04655	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND439_04660	COG1466	dna polymerase III delta subunit
ND439_04665	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND439_04675	COG2888	peptidyl-tyrosine sulfation
ND439_04680	COG1126	abc transporter atp-binding protein
ND439_04685	COG0765	amino acid transport
ND439_04690	COG0765	amino acid transport
ND439_04700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND439_04705	COG4535	Mg2 and Co2 transporter CorC
ND439_04710	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND439_04715	COG1702	phosphate starvation-inducible protein PhoH
ND439_04720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND439_04725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND439_04760	COG0367	asparagine synthase
ND439_04765	COG0647	UMP catabolic process
ND439_04770	COG1940	carbohydrate kinase activity
ND439_04770	COG1846	Transcriptional regulator
ND439_04775	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND439_04785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND439_04785	COG2190	(PTS) system
ND439_04785	COG1263	PTS System
ND439_04810	COG0735	belongs to the Fur family
ND439_04820	COG0840	transmembrane signaling receptor activity
ND439_04830	COG0596	Alpha beta hydrolase
ND439_04835	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND439_04840	COG0033	Phosphoglucomutase
ND439_04850	COG0745	RESPONSE REGULATOR receiver
ND439_04855	COG2205	protein histidine kinase activity
ND439_04860	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND439_04865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND439_04885	COG3272	Protein of unknown function (DUF1722)
ND439_04890	COG0415	Belongs to the DNA photolyase family
ND439_04895	COG5212	phosphodiesterase
ND439_04900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND439_04905	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND439_04910	COG1984	allophanate hydrolase subunit 2
ND439_04915	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND439_04960	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND439_04965	COG1053	succinate dehydrogenase
ND439_04970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND439_04975	COG0567	Dehydrogenase, E1 component
ND439_04980	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND439_04985	COG0045	succinate-CoA ligase (ADP-forming) activity
ND439_04990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND439_04995	COG0737	Belongs to the 5'-nucleotidase family
ND439_05000	COG1271	oxidase subunit
ND439_05005	COG1294	oxidase, subunit
ND439_05010	COG4890	Cyd operon protein YbgT
ND439_05015	COG3790	cyd operon protein YbgE
ND439_05020	COG0824	Thioesterase
ND439_05025	COG0811	peptide transport
ND439_05030	COG0848	biopolymer transport protein
ND439_05035	COG3064	Membrane
ND439_05035	COG3064	Membrane
ND439_05040	COG0823	Involved in the tonB-independent uptake of proteins
ND439_05045	COG2885	chlorophyll binding
ND439_05050	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND439_05080	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND439_05090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND439_05090	COG2205	protein histidine kinase activity
ND439_05100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND439_05105	COG0588	phosphoglycerate mutase activity
ND439_05115	COG2017	converts alpha-aldose to the beta-anomer
ND439_05125	COG1085	galactose-1-phosphate uridylyltransferase
ND439_05130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND439_05145	COG3585	molybdate ion transport
ND439_05145	COG2005	Transcriptional regulator
ND439_05155	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND439_05160	COG4149	molybdate abc transporter
ND439_05170	COG0561	phosphatase activity
ND439_05175	COG2706	6-phosphogluconolactonase activity
ND439_05190	COG0156	8-amino-7-oxononanoate synthase activity
ND439_05195	COG2226	methyltransferase
ND439_05210	COG0556	nucleotide-excision repair
ND439_05215	COG4628	conserved protein (DUF2132)
ND439_05230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND439_05235	COG1120	ATPase activity
ND439_05240	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND439_05245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND439_05255	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND439_05260	COG0314	molybdopterin synthase activity
ND439_05265	COG0670	Belongs to the BI1 family
ND439_05270	COG0842	Transport permease protein
ND439_05275	COG0842	Transport permease protein
ND439_05280	COG1131	(ABC) transporter
ND439_05285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND439_05290	COG1309	transcriptional regulator
ND439_05295	COG0513	Belongs to the DEAD box helicase family
ND439_05300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND439_05310	COG1686	Belongs to the peptidase S11 family
ND439_05315	COG0277	FAD linked oxidase domain protein
ND439_05335	COG2261	transglycosylase associated protein
ND439_05345	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND439_05355	COG3639	organic phosphonate transmembrane transporter activity
ND439_05360	COG4807	Protein conserved in bacteria
ND439_05365	COG2897	thiosulfate sulfurtransferase activity
ND439_05370	COG1732	Glycine betaine
ND439_05375	COG1174	glycine betaine transport
ND439_05380	COG1125	glycine betaine transport
ND439_05385	COG1174	glycine betaine transport
ND439_05390	COG0531	amino acid
ND439_05395	COG1982	Orn Lys Arg decarboxylase major
ND439_05405	COG0697	spore germination
ND439_05420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND439_05425	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND439_05430	COG1126	abc transporter atp-binding protein
ND439_05435	COG0765	amino acid transport
ND439_05440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND439_05460	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND439_05465	COG2239	Acts as a magnesium transporter
ND439_05470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND439_05475	COG0488	(ABC) transporter
ND439_05480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND439_05485	COG0303	'Molybdopterin
ND439_05505	COG0583	DNA-binding transcription factor activity
ND439_05510	COG0477	Major facilitator Superfamily
ND439_05515	COG0302	gtp cyclohydrolase
ND439_05520	COG2311	Membrane
ND439_05545	COG2949	membrane
ND439_05550	COG0281	malic enzyme
ND439_05560	COG0583	DNA-binding transcription factor activity
ND439_05570	COG1346	cytolysis
ND439_05575	COG1380	Effector of murein hydrolase LrgA
ND439_05585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND439_05585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND439_05590	COG0489	protein tyrosine kinase activity
ND439_05595	COG0572	uridine kinase
ND439_05600	COG0717	Belongs to the dCTP deaminase family
ND439_05605	COG2982	Protein involved in outer membrane biogenesis
ND439_05610	COG3069	C4-dicarboxylate transmembrane transporter activity
ND439_05615	COG1253	flavin adenine dinucleotide binding
ND439_05620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND439_05625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND439_05630	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND439_05640	COG0140	phosphoribosyl-ATP diphosphatase activity
ND439_05640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND439_05650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND439_05660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND439_05660	COG0131	Imidazoleglycerol-phosphate dehydratase
ND439_05665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND439_05670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND439_05685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND439_05690	COG0625	glutathione transferase activity
ND439_05705	COG0626	cystathionine gamma-synthase activity
ND439_05715	COG1686	Belongs to the peptidase S11 family
ND439_05720	COG1760	l-serine dehydratase
ND439_05725	COG0814	amino acid
ND439_05730	COG1349	DNA-binding transcription factor activity
ND439_05740	COG0671	phosphoesterase, PA-phosphatase related
ND439_05750	COG0569	domain protein
ND439_05750	COG2985	domain, Protein
ND439_05770	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND439_05775	COG3842	ATPase activity
ND439_05780	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND439_05785	COG1177	transmembrane transport
ND439_05800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND439_05805	COG4160	amino acid transport
ND439_05810	COG4215	(ABC) transporter
ND439_05815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND439_05820	COG1126	abc transporter atp-binding protein
ND439_05830	COG0393	Putative heavy-metal-binding
ND439_05835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND439_05840	COG0702	epimerase
ND439_05845	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND439_05850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND439_05855	COG1151	hydroxylamine reductase activity
ND439_05860	COG2431	L-lysine efflux transmembrane transporter activity
ND439_05865	COG3593	DNA synthesis involved in DNA repair
ND439_05870	COG2990	Protein conserved in bacteria
ND439_05875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND439_05885	COG1278	Cold shock
ND439_05890	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND439_05895	COG0542	response to heat
ND439_05900	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND439_05910	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND439_05920	COG0492	ferredoxin-NADP+ reductase activity
ND439_05925	COG1522	sequence-specific DNA binding
ND439_05930	COG3107	peptidoglycan biosynthetic process
ND439_05930	COG1674	ftsk spoiiie
ND439_05935	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND439_05940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND439_05945	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND439_05950	COG2814	Major facilitator Superfamily
ND439_05955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND439_05960	COG1882	Formate acetyltransferase
ND439_05965	COG2116	formate transmembrane transporter activity
ND439_05970	COG1944	ATP diphosphatase activity
ND439_05975	COG0252	asparaginase activity
ND439_05985	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND439_05995	COG0539	negative regulation of cytoplasmic translation
ND439_06005	COG0658	competence protein
ND439_06005	COG2333	competence protein COMEC
ND439_06015	COG1663	tetraacyldisaccharide 4'-kinase activity
ND439_06020	COG5383	Protein conserved in bacteria
ND439_06030	COG1278	Cold shock
ND439_06035	COG2835	tetraacyldisaccharide 4'-kinase activity
ND439_06040	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND439_06045	COG3173	Aminoglycoside phosphotransferase
ND439_06050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND439_06055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND439_06060	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND439_06070	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND439_06075	COG2989	Protein conserved in bacteria
ND439_06080	COG3108	Peptidase M15
ND439_06085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND439_06090	COG1448	Aminotransferase
ND439_06105	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND439_06110	COG0308	aminopeptidase N
ND439_06115	COG0167	dihydroorotate dehydrogenase activity
ND439_06125	COG0633	Ferredoxin
ND439_06125	COG3217	Mosc domain protein beta barrel domain protein
ND439_06130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND439_06130	COG0116	Belongs to the methyltransferase superfamily
ND439_06135	COG0488	(ABC) transporter
ND439_06140	COG2995	paraquat-inducible protein a
ND439_06145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND439_06145	COG3008	intermembrane lipid transfer
ND439_06150	COG3009	Protein conserved in bacteria
ND439_06155	COG3130	regulation of translation
ND439_06160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND439_06165	COG1067	ATP-dependent peptidase activity
ND439_06170	COG3120	sequence-specific DNA binding
ND439_06180	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND439_06185	COG3070	regulator of competence-specific genes
ND439_06190	COG1289	transmembrane transporter activity
ND439_06195	COG3304	Inner membrane component domain
ND439_06200	COG0210	DNA helicase
ND439_06205	COG1803	Methylglyoxal synthase
ND439_06215	COG1832	CoA-binding protein
ND439_06220	COG3785	DNA binding
ND439_06225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND439_06235	COG2920	part of a sulfur-relay system
ND439_06245	COG0288	reversible hydration of carbon dioxide
ND439_06265	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND439_06270	COG2943	transferase activity, transferring hexosyl groups
ND439_06275	COG0346	lactoylglutathione lyase activity
ND439_06290	COG1560	Kdo2-lipid A biosynthetic process
ND439_06300	COG0628	permease
ND439_06325	COG0418	dihydroorotase activity
ND439_06330	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND439_06340	COG1530	ribonuclease E activity
ND439_06345	COG0564	pseudouridine synthase activity
ND439_06350	COG0424	maF-like protein
ND439_06355	COG1399	metal-binding, possibly nucleic acid-binding protein
ND439_06360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND439_06370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND439_06375	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND439_06385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND439_06390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND439_06395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND439_06400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND439_06405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND439_06410	COG0470	DNA polymerase III
ND439_06415	COG0084	hydrolase, TatD family'
ND439_06420	COG1263	PTS System
ND439_06420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND439_06425	COG0537	adenosine 5'-monophosphoramidase activity
ND439_06430	COG5633	Lipoprotein
ND439_06435	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND439_06450	COG3150	esterase
ND439_06455	COG1252	NADH dehydrogenase
ND439_06460	COG3134	Outer membrane lipoprotein
ND439_06465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND439_06470	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND439_06480	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND439_06500	COG2850	peptidyl-arginine hydroxylation
ND439_06505	COG2205	protein histidine kinase activity
ND439_06510	COG0745	RESPONSE REGULATOR receiver
ND439_06520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND439_06525	COG2915	High frequency lysogenization protein hflD homolog
ND439_06530	COG0482	sulfurtransferase activity
ND439_06540	COG1187	pseudouridine synthase activity
ND439_06545	COG0538	isocitrate dehydrogenase activity
ND439_06550	COG2771	luxR family
ND439_06555	COG3916	Acyl-homoserine-lactone synthase
ND439_06560	COG2723	6-phospho-beta-galactosidase activity
ND439_06570	COG0339	signal peptide processing
ND439_06580	COG3493	citrate carrier protein
ND439_06585	COG4565	transcriptional regulatory protein
ND439_06590	COG3290	protein histidine kinase activity
ND439_06595	COG0471	metal ion transport
ND439_06635	COG4977	sequence-specific DNA binding
ND439_06640	COG1702	phosphate starvation-inducible protein PhoH
ND439_06645	COG0387	Pfam Sodium calcium exchanger
ND439_06650	COG2375	cellular response to nickel ion
ND439_06655	COG3850	Histidine kinase
ND439_06665	COG1294	oxidase, subunit
ND439_06670	COG1271	oxidase subunit
ND439_06675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND439_06680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND439_06685	COG3138	arginine N-succinyltransferase
ND439_06695	COG3724	N-succinylarginine dihydrolase activity
ND439_06715	COG1228	amidohydrolase
ND439_06725	COG0402	S-adenosylhomocysteine deaminase activity
ND439_06745	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND439_06750	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND439_06755	COG3383	formate dehydrogenase (NAD+) activity
ND439_06760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND439_06765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND439_06775	COG3260	NADH ubiquinone oxidoreductase 20
ND439_06780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND439_06785	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND439_06785	COG3261	NADH dehydrogenase
ND439_06790	COG0650	Formate hydrogenlyase subunit 4
ND439_06795	COG0651	ATP synthesis coupled electron transport
ND439_06800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND439_06810	COG0375	protein maturation
ND439_06815	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND439_06820	COG0298	carbon dioxide binding
ND439_06825	COG0409	Hydrogenase expression formation protein
ND439_06830	COG0309	Hydrogenase expression formation protein (HypE)
ND439_06850	COG0012	GTP binding
ND439_06860	COG0193	aminoacyl-tRNA hydrolase activity
ND439_06870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND439_06880	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND439_06885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND439_06890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND439_06895	COG2890	protein-(glutamine-N5) methyltransferase activity
ND439_06910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND439_06915	COG0659	secondary active sulfate transmembrane transporter activity
ND439_06920	COG3706	GGDEF domain
ND439_06945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND439_06955	COG3381	protein complex oligomerization
ND439_06975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND439_06985	COG0673	inositol 2-dehydrogenase activity
ND439_06990	COG0728	peptidoglycan biosynthetic process
ND439_07015	COG3102	Protein conserved in bacteria
ND439_07020	COG3142	Participates in the control of copper homeostasis
ND439_07035	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND439_07040	COG1801	Protein of unknown function DUF72
ND439_07050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND439_07055	COG0494	nUDIX hydrolase
ND439_07065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND439_07075	COG2255	four-way junction helicase activity
ND439_07080	COG3104	oligopeptide transport
ND439_07085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND439_07090	COG1121	(ABC) transporter
ND439_07095	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND439_07100	COG0739	heme binding
ND439_07105	COG1560	Kdo2-lipid A biosynthetic process
ND439_07110	COG0469	pyruvate kinase activity
ND439_07115	COG1737	Transcriptional regulator
ND439_07120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND439_07125	COG0800	Aldolase
ND439_07135	COG2076	Multidrug Resistance protein
ND439_07140	COG0251	oxidation-reduction process
ND439_07145	COG1199	ATP-dependent helicase activity
ND439_07150	COG1214	PFAM Peptidase M22, glycoprotease
ND439_07155	COG3065	identical protein binding
ND439_07160	COG0318	PFAM AMP-dependent synthetase and ligase
ND439_07165	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND439_07170	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND439_07175	COG2894	cell division
ND439_07180	COG0850	regulation of cytokinetic process
ND439_07185	COG3100	YcgL domain-containing protein
ND439_07190	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND439_07195	COG2983	Belongs to the UPF0260 family
ND439_07215	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND439_07225	COG2719	SpoVR family
ND439_07230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND439_07235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND439_07240	COG2814	Major facilitator Superfamily
ND439_07250	COG2202	Pas domain
ND439_07250	COG2200	EAL domain
ND439_07250	COG2199	diguanylate cyclase activity
ND439_07270	COG2718	Belongs to the UPF0229 family
ND439_07275	COG2766	serine protein kinase
ND439_07285	COG3713	MltA-interacting MipA family protein
ND439_07290	COG2194	sulfuric ester hydrolase activity
ND439_07305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND439_07310	COG3139	Protein of unknown function (DUF1315)
ND439_07315	COG1335	isochorismatase
ND439_07320	COG0252	asparaginase activity
ND439_07325	COG0616	signal peptide processing
ND439_07330	COG0778	Nitroreductase
ND439_07340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND439_07350	COG0494	nUDIX hydrolase
ND439_07355	COG0708	Exodeoxyribonuclease III
ND439_07390	COG0788	formyltetrahydrofolate deformylase activity
ND439_07400	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND439_07405	COG0745	RESPONSE REGULATOR receiver
ND439_07425	COG1454	alcohol dehydrogenase
ND439_07425	COG1012	belongs to the aldehyde dehydrogenase family
ND439_07435	COG2095	MarC family integral membrane protein
ND439_07440	COG4166	transmembrane transport
ND439_07455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND439_07470	COG3099	Belongs to the UPF0263 family
ND439_07475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND439_07495	COG2350	Protein conserved in bacteria
ND439_07510	COG3710	Transcriptional regulator
ND439_07545	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND439_07570	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND439_07575	COG3047	cAMP biosynthetic process
ND439_07590	COG0133	tryptophan synthase activity
ND439_07595	COG0135	phosphoribosylanthranilate isomerase activity
ND439_07595	COG0134	indole-3-glycerol-phosphate synthase activity
ND439_07605	COG0512	Glutamine amidotransferase of anthranilate synthase
ND439_07615	COG0613	PHP domain protein
ND439_07620	COG0009	L-threonylcarbamoyladenylate synthase
ND439_07625	COG1187	pseudouridine synthase activity
ND439_07635	COG1028	Short-chain dehydrogenase reductase Sdr
ND439_07640	COG0616	signal peptide processing
ND439_07655	COG0583	DNA-binding transcription factor activity
ND439_07675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND439_07685	COG0671	phosphoesterase, PA-phosphatase related
ND439_07690	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND439_07695	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND439_07730	COG0463	Glycosyl transferase, family 2
ND439_07785	COG4974	Belongs to the 'phage' integrase family
ND439_07800	COG0023	Translation Initiation Factor
ND439_07810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND439_07815	COG3447	MASE1 domain protein
ND439_07815	COG5001	Diguanylate cyclase
ND439_07815	COG5002	protein histidine kinase activity
ND439_07820	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND439_07825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND439_07835	COG4659	FMN binding
ND439_07845	COG2207	Transcriptional regulator
ND439_07845	COG3708	Transcriptional regulator
ND439_07860	COG4657	Part of a membrane complex involved in electron transport
ND439_07870	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND439_07880	COG0673	inositol 2-dehydrogenase activity
ND439_07885	COG0385	Bile acid
ND439_07890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND439_07910	COG5339	Protein conserved in bacteria
ND439_07915	COG1482	cell wall glycoprotein biosynthetic process
ND439_07920	COG0114	fumarate hydratase activity
ND439_07940	COG1940	carbohydrate kinase activity
ND439_07945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND439_07965	COG1742	UPF0060 membrane protein
ND439_07970	COG4221	oxidoreductase activity
ND439_07975	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND439_07990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND439_08030	COG1011	Hydrolase
ND439_08040	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND439_08045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND439_08050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND439_08055	COG0589	response to stress
ND439_08085	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND439_08090	COG3623	hexulose-6-phosphate isomerase
ND439_08095	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND439_08100	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND439_08110	COG0531	amino acid
ND439_08120	COG0745	RESPONSE REGULATOR receiver
ND439_08125	COG2205	protein histidine kinase activity
ND439_08140	COG2207	Transcriptional regulator
ND439_08145	COG1881	PFAM PEBP family protein
ND439_08155	COG3591	Belongs to the peptidase S1B family
ND439_08160	COG1643	Atp-dependent helicase
ND439_08165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND439_08170	COG3784	Protein of unknown function (DUF1318)
ND439_08185	COG2911	Protein conserved in bacteria
ND439_08190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND439_08195	COG3187	Heat shock protein
ND439_08200	COG3042	response to heat
ND439_08205	COG1285	pathogenesis
ND439_08215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND439_08215	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND439_08215	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND439_08215	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND439_08230	COG4166	transmembrane transport
ND439_08235	COG2866	Carboxypeptidase
ND439_08240	COG4948	Mandelate Racemase Muconate Lactonizing
ND439_08245	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND439_08255	COG5642	Protein of unknown function (DUF2384)
ND439_08260	COG5654	RES domain protein
ND439_08265	COG3768	UPF0283 membrane protein
ND439_08270	COG3106	COG3106 Predicted ATPase
ND439_08275	COG1983	PspC domain protein
ND439_08285	COG1842	Phage shock protein A
ND439_08290	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND439_08305	COG4166	transmembrane transport
ND439_08315	COG4171	peptide transport system, permease
ND439_08320	COG4172	Belongs to the ABC transporter superfamily
ND439_08325	COG4172	Belongs to the ABC transporter superfamily
ND439_08335	COG3104	oligopeptide transport
ND439_08345	COG0484	heat shock protein binding
ND439_08390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND439_08395	COG3133	Outer membrane lipoprotein
ND439_08400	COG1846	Transcriptional regulator
ND439_08410	COG4989	oxidoreductase activity
ND439_08415	COG3313	Fe-S protein
ND439_08420	COG2194	sulfuric ester hydrolase activity
ND439_08425	COG1309	transcriptional regulator
ND439_08430	COG1902	pentaerythritol trinitrate reductase activity
ND439_08445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND439_08450	COG0791	NLP P60 protein
ND439_08455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND439_08465	COG1609	Transcriptional regulator
ND439_08470	COG0583	DNA-binding transcription factor activity
ND439_08475	COG2814	Major facilitator Superfamily
ND439_08480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND439_08485	COG0307	riboflavin synthase, alpha
ND439_08520	COG1388	LysM domain
ND439_08520	COG1376	ErfK ybiS ycfS ynhG family protein
ND439_08525	COG2166	iron-sulfur cluster assembly
ND439_08535	COG0719	Fe-S assembly protein
ND439_08540	COG0396	ATPase activity
ND439_08545	COG0719	Fe-S assembly protein
ND439_08550	COG0316	Belongs to the HesB IscA family
ND439_08555	COG2050	protein possibly involved in aromatic compounds catabolism
ND439_08560	COG0247	lactate metabolic process
ND439_08560	COG0277	FAD linked oxidase domain protein
ND439_08565	COG0628	permease
ND439_08575	COG0574	Belongs to the PEP-utilizing enzyme family
ND439_08575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND439_08580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND439_08585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND439_08595	COG4771	TonB-dependent receptor
ND439_08600	COG3720	iron ion transport
ND439_08605	COG4558	Periplasmic binding protein
ND439_08610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND439_08615	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND439_08625	COG0095	Lipoate-protein ligase
ND439_08630	COG0791	NLP P60 protein
ND439_08635	COG2076	Multidrug Resistance protein
ND439_08640	COG2076	Multidrug Resistance protein
ND439_08645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND439_08660	COG0463	Glycosyl transferase, family 2
ND439_08665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND439_08675	COG4139	cobalamin transport
ND439_08680	COG4974	Belongs to the 'phage' integrase family
ND439_08720	COG0776	regulation of translation
ND439_08790	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND439_08795	COG1121	(ABC) transporter
ND439_08800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND439_08805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND439_08810	COG3001	Fructosamine kinase
ND439_08820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND439_08825	COG1988	membrane-bound metal-dependent
ND439_08830	COG1823	symporter activity
ND439_08835	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND439_08845	COG2814	Major facilitator Superfamily
ND439_08855	COG0501	Belongs to the peptidase M48B family
ND439_08860	COG0793	Belongs to the peptidase S41A family
ND439_08870	COG1956	GAF domain-containing protein
ND439_08875	COG2995	paraquat-inducible protein a
ND439_08880	COG3008	intermembrane lipid transfer
ND439_08885	COG2203	Gaf domain
ND439_08885	COG3706	GGDEF domain
ND439_08885	COG5001	Diguanylate cyclase
ND439_08885	COG4251	negative regulation of phosphorylation
ND439_08965	COG1276	copper resistance
ND439_08970	COG2372	response to copper ion
ND439_08975	COG1528	Iron-storage protein
ND439_08990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND439_08995	COG1770	oligopeptidase
ND439_09005	COG3097	Belongs to the UPF0267 family
ND439_09010	COG3141	response to X-ray
ND439_09015	COG0513	Belongs to the DEAD box helicase family
ND439_09035	COG0494	nUDIX hydrolase
ND439_09040	COG1760	l-serine dehydratase
ND439_09045	COG1253	flavin adenine dinucleotide binding
ND439_09050	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND439_09050	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND439_09055	COG3715	PTS system
ND439_09060	COG3716	PTS system mannose fructose sorbose family IID component
ND439_09065	COG4811	Protein of unknown function (DUF986)
ND439_09070	COG1971	Probably functions as a manganese efflux pump
ND439_09090	COG1960	acyl-CoA dehydrogenase activity
ND439_09100	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND439_09130	COG2226	methyltransferase
ND439_09135	COG0768	penicillin binding
ND439_09140	COG1496	oxidoreductase activity
ND439_09160	COG1113	amino acid transport
ND439_09195	COG2207	Transcriptional regulator
ND439_09215	COG1132	(ABC) transporter
ND439_09225	COG4251	negative regulation of phosphorylation
ND439_09225	COG3706	GGDEF domain
ND439_09225	COG2203	Gaf domain
ND439_09225	COG5001	Diguanylate cyclase
ND439_09245	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND439_09265	COG1278	Cold shock
ND439_09270	COG1278	Cold shock
ND439_09285	COG1917	Cupin 2, conserved barrel domain protein
ND439_09285	COG2169	Transcriptional regulator
ND439_09290	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND439_09295	COG2723	6-phospho-beta-galactosidase activity
ND439_09300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND439_09305	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND439_09310	COG1187	pseudouridine synthase activity
ND439_09320	COG3122	Protein conserved in bacteria
ND439_09325	COG1757	Na H antiporter
ND439_09340	COG2235	arginine
ND439_09355	COG0076	glutamate decarboxylase activity
ND439_09360	COG0531	amino acid
ND439_09395	COG2153	protein acetylation
ND439_09400	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND439_09435	COG0840	transmembrane signaling receptor activity
ND439_09440	COG2801	Transposase and inactivated derivatives
ND439_09460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND439_09465	COG0322	excinuclease ABC activity
ND439_09470	COG2197	response regulator
ND439_09495	COG1113	amino acid transport
ND439_09505	COG0531	amino acid
ND439_09510	COG3710	Transcriptional regulator
ND439_09515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND439_09520	COG0506	proline dehydrogenase activity
ND439_09520	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND439_09520	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND439_09525	COG1126	abc transporter atp-binding protein
ND439_09530	COG0765	amino acid transport
ND439_09535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND439_09540	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND439_09550	COG1191	sigma factor activity
ND439_09590	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND439_09595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND439_09605	COG1677	Flagellar hook-basal body complex protein FliE
ND439_09615	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND439_09625	COG1157	protein secretion by the type III secretion system
ND439_09640	COG1580	Controls the rotational direction of flagella during chemotaxis
ND439_09720	COG1558	bacterial-type flagellum-dependent cell motility
ND439_09725	COG1815	bacterial-type flagellum-dependent cell motility
ND439_09735	COG2747	anti-sigma28 factor FlgM
ND439_09740	COG3418	PFAM FlgN family protein
ND439_09750	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND439_09755	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND439_09765	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND439_09770	COG0745	RESPONSE REGULATOR receiver
ND439_09780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND439_09785	COG0840	transmembrane signaling receptor activity
ND439_09790	COG0840	transmembrane signaling receptor activity
ND439_09795	COG0835	chemotaxis
ND439_09800	COG2198	Histidine kinase
ND439_09800	COG0643	Histidine kinase
ND439_09805	COG1360	Flagellar Motor Protein
ND439_09825	COG0589	response to stress
ND439_09835	COG1285	pathogenesis
ND439_09840	COG0840	transmembrane signaling receptor activity
ND439_09860	COG1609	Transcriptional regulator
ND439_09870	COG0604	alcohol dehydrogenase
ND439_09870	COG1028	Short-chain dehydrogenase reductase Sdr
ND439_09870	COG3321	synthase
ND439_09905	COG0582	viral genome integration into host DNA
ND439_09920	COG3423	Transcriptional regulator
ND439_09965	COG0471	metal ion transport
ND439_09980	COG3051	citrate lyase alpha subunit
ND439_09985	COG2301	Belongs to the HpcH HpaI aldolase family
ND439_09990	COG3052	prosthetic group binding
ND439_09995	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND439_10000	COG3290	protein histidine kinase activity
ND439_10005	COG4565	transcriptional regulatory protein
ND439_10020	COG2271	Major facilitator Superfamily
ND439_10025	COG1840	ABC-type Fe3 transport system, periplasmic component
ND439_10035	COG3842	ATPase activity
ND439_10055	COG1289	transmembrane transporter activity
ND439_10065	COG2925	Exonuclease
ND439_10070	COG0531	amino acid
ND439_10075	COG4771	TonB-dependent receptor
ND439_10085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND439_10095	COG0833	amino acid
ND439_10100	COG0583	DNA-binding transcription factor activity
ND439_10110	COG2855	membrane
ND439_10115	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND439_10120	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND439_10120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND439_10120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND439_10125	COG1105	Belongs to the carbohydrate kinase PfkB family
ND439_10140	COG3005	denitrification pathway
ND439_10145	COG0243	molybdopterin cofactor binding
ND439_10160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND439_10170	COG0246	Mannitol dehydrogenase
ND439_10180	COG0523	cobalamin synthesis protein
ND439_10185	COG0671	phosphoesterase, PA-phosphatase related
ND439_10190	COG0791	NLP P60 protein
ND439_10195	COG2200	EAL domain
ND439_10200	COG4166	transmembrane transport
ND439_10205	COG4174	ABC transporter (Permease)
ND439_10210	COG4239	(ABC) transporter, permease
ND439_10215	COG4172	Belongs to the ABC transporter superfamily
ND439_10225	COG2814	Major facilitator Superfamily
ND439_10230	COG1187	pseudouridine synthase activity
ND439_10235	COG1061	Type III restriction enzyme res subunit
ND439_10250	COG3082	Protein of unknown function (DUF1414)
ND439_10255	COG3083	sulfuric ester hydrolase activity
ND439_10285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND439_10290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND439_10310	COG2223	nitrite transmembrane transporter activity
ND439_10315	COG0642	Histidine kinase
ND439_10315	COG2198	Histidine kinase
ND439_10325	COG2205	protein histidine kinase activity
ND439_10325	COG0784	Response regulator, receiver
ND439_10335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND439_10340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND439_10350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND439_10360	COG4574	serine-type endopeptidase inhibitor activity
ND439_10370	COG2246	polysaccharide biosynthetic process
ND439_10385	COG0814	amino acid
ND439_10410	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND439_10415	COG0596	Alpha beta hydrolase
ND439_10420	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND439_10425	COG1169	isochorismate synthase
ND439_10430	COG4575	ribosome binding
ND439_10445	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND439_10450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND439_10460	COG0839	Belongs to the complex I subunit 6 family
ND439_10465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND439_10470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND439_10475	COG1034	ATP synthesis coupled electron transport
ND439_10495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND439_10500	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND439_10505	COG0583	DNA-binding transcription factor activity
ND439_10510	COG0436	Aminotransferase
ND439_10515	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND439_10520	COG0471	metal ion transport
ND439_10520	COG0490	domain, Protein
ND439_10530	COG3013	Belongs to the UPF0304 family
ND439_10535	COG3092	negative regulation of chromosome organization
ND439_10545	COG0857	belongs to the CobB CobQ family
ND439_10545	COG0280	phosphate acetyltransferase
ND439_10550	COG1609	Transcriptional regulator
ND439_10565	COG3037	sugar-specific permease SgaT UlaA
ND439_10570	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND439_10575	COG0622	Phosphoesterase
ND439_10585	COG0625	glutathione transferase activity
ND439_10590	COG1090	epimerase
ND439_10600	COG4160	amino acid transport
ND439_10605	COG4215	(ABC) transporter
ND439_10620	COG0163	prenyltransferase activity
ND439_10625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND439_10630	COG1286	toxin biosynthetic process
ND439_10635	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND439_10640	COG0285	dihydrofolate synthase activity
ND439_10650	COG0586	Pfam SNARE associated Golgi protein
ND439_10660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND439_10685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND439_10690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND439_10720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND439_10735	COG3101	peptidyl-lysine hydroxylation
ND439_10740	COG0730	response to heat
ND439_10745	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND439_10755	COG2890	protein-(glutamine-N5) methyltransferase activity
ND439_10760	COG2840	Smr protein MutS2
ND439_10765	COG2062	phosphohistidine phosphatase, SixA
ND439_10770	COG1024	Enoyl-CoA hydratase
ND439_10770	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND439_10775	COG0183	Belongs to the thiolase family
ND439_10780	COG3691	Protein conserved in bacteria
ND439_10795	COG4235	cytochrome complex assembly
ND439_10795	COG3088	subunit of a heme lyase
ND439_10800	COG4235	cytochrome complex assembly
ND439_10800	COG3088	subunit of a heme lyase
ND439_10805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND439_10810	COG1138	Cytochrome C-type biogenesis protein
ND439_10815	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND439_10820	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND439_10825	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND439_10830	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND439_10845	COG0582	viral genome integration into host DNA
ND439_10850	COG3311	Transcriptional regulator
ND439_10925	COG2824	Alkylphosphonate utilization operon protein PhnA
ND439_10930	COG2951	lytic endotransglycosylase activity
ND439_10935	COG1598	PFAM Uncharacterised protein family UPF0150
ND439_10945	COG3038	cytochrome b561
ND439_10950	COG0436	Aminotransferase
ND439_10960	COG3275	phosphorelay sensor kinase activity
ND439_10965	COG3279	Response regulator of the LytR AlgR family
ND439_10970	COG2223	nitrite transmembrane transporter activity
ND439_10975	COG0837	glucose binding
ND439_10995	COG1914	H( )-stimulated, divalent metal cation uptake system
ND439_11000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND439_11055	COG3530	Putative quorum-sensing-regulated virulence factor
ND439_11060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND439_11070	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND439_11080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND439_11095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND439_11105	COG4208	sulfate ABC transporter
ND439_11110	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND439_11115	COG4150	thiosulfate binding
ND439_11125	COG1737	Transcriptional regulator
ND439_11130	COG2731	YhcH YjgK YiaL family protein
ND439_11145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND439_11150	COG2837	iron assimilation
ND439_11160	COG3111	PFAM Bacterial OB fold (BOF) protein
ND439_11175	COG1671	Belongs to the UPF0178 family
ND439_11180	COG0281	malic enzyme
ND439_11180	COG0280	phosphate acetyltransferase
ND439_11185	COG0494	nUDIX hydrolase
ND439_11190	COG3005	denitrification pathway
ND439_11195	COG3043	anaerobic respiration
ND439_11200	COG0243	molybdopterin cofactor binding
ND439_11205	COG3062	negative regulation of establishment of protein localization
ND439_11210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND439_11210	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND439_11215	COG2197	response regulator
ND439_11225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND439_11235	COG1605	Chorismate mutase
ND439_11240	COG1393	Belongs to the ArsC family
ND439_11245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND439_11250	COG1876	peptidase activity
ND439_11260	COG0400	carboxylic ester hydrolase activity
ND439_11280	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND439_11285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND439_11290	COG2716	regulation of RNA biosynthetic process
ND439_11295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND439_11300	COG0628	permease
ND439_11305	COG4783	chaperone-mediated protein folding
ND439_11310	COG1393	Belongs to the ArsC family
ND439_11315	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND439_11320	COG2233	PERMEase
ND439_11325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND439_11330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND439_11335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND439_11340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND439_11350	COG0581	inorganic phosphate transmembrane transporter activity
ND439_11355	COG0573	inorganic phosphate transmembrane transporter activity
ND439_11360	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND439_11375	COG2239	Acts as a magnesium transporter
ND439_11380	COG0443	Heat shock 70 kDa protein
ND439_11390	COG3121	Chaperone
ND439_11405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND439_11415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND439_11420	COG0477	Major facilitator Superfamily
ND439_11425	COG2205	protein histidine kinase activity
ND439_11430	COG0745	RESPONSE REGULATOR receiver
ND439_11435	COG3422	double-strand break repair
ND439_11440	COG0826	peptidase U32
ND439_11445	COG1597	lipid kinase activity
ND439_11460	COG0351	phosphomethylpyrimidine kinase
ND439_11470	COG0519	Catalyzes the synthesis of GMP from XMP
ND439_11470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND439_11475	COG0517	IMP dehydrogenase activity
ND439_11475	COG0516	GMP reductase activity
ND439_11480	COG1570	exodeoxyribonuclease VII activity
ND439_11485	COG1645	bacterial-type flagellum-dependent swarming motility
ND439_11495	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND439_11500	COG2976	Protein conserved in bacteria
ND439_11505	COG0124	histidyl-tRNA synthetase
ND439_11525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND439_11540	COG4953	penicillin-binding protein 1C
ND439_11545	COG2373	Large extracellular alpha-helical protein
ND439_11560	COG2975	iron-sulfur cluster assembly
ND439_11565	COG0633	Ferredoxin
ND439_11570	COG0443	Heat shock 70 kDa protein
ND439_11585	COG0822	iron-sulfur transferase activity
ND439_11595	COG1959	2 iron, 2 sulfur cluster binding
ND439_11600	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND439_11610	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND439_11615	COG3683	transport system, periplasmic component
ND439_11620	COG3711	transcriptional antiterminator
ND439_11625	COG2814	Major facilitator Superfamily
ND439_11635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND439_11635	COG1017	nitric oxide dioxygenase activity
ND439_11640	COG2188	Transcriptional regulator
ND439_11650	COG3457	Alanine racemase
ND439_11655	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND439_11670	COG0347	Belongs to the P(II) protein family
ND439_11675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND439_11675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND439_11680	COG2204	response regulator
ND439_11685	COG3170	Tfp pilus assembly protein FimV
ND439_11690	COG2205	protein histidine kinase activity
ND439_11705	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND439_11715	COG0560	Phosphoserine phosphatase
ND439_11720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND439_11720	COG1263	PTS System
ND439_11730	COG1737	Transcriptional regulator
ND439_11735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND439_11745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND439_11755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND439_11770	COG0481	GTPase activity
ND439_11775	COG3086	response to oxidative stress
ND439_11785	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND439_11795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND439_11805	COG0513	Belongs to the DEAD box helicase family
ND439_11820	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND439_11830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND439_11835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND439_11840	COG0497	DNA recombination
ND439_11845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND439_11855	COG2867	negative regulation of translational initiation
ND439_11860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND439_11870	COG0582	viral genome integration into host DNA
ND439_11910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND439_11990	COG1069	ribulokinase activity
ND439_12000	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND439_12005	COG1129	ABC transporter
ND439_12025	COG1620	l-lactate permease
ND439_12030	COG1304	FMN binding
ND439_12035	COG0579	oxidoreductase
ND439_12040	COG1278	Cold shock
ND439_12070	COG1780	Probably involved in ribonucleotide reductase function
ND439_12075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND439_12085	COG4175	Glycine betaine
ND439_12090	COG4176	ABC-type proline glycine betaine transport system permease component
ND439_12095	COG2113	Glycine betaine
ND439_12100	COG2814	Major facilitator Superfamily
ND439_12105	COG1846	Transcriptional regulator
ND439_12115	COG1566	PFAM secretion protein HlyD family protein
ND439_12120	COG2814	Major facilitator Superfamily
ND439_12125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND439_12130	COG3118	belongs to the thioredoxin family
ND439_12135	COG3148	PFAM DTW domain containing protein
ND439_12140	COG1042	CoA-binding domain protein
ND439_12140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND439_12140	COG0045	succinate-CoA ligase (ADP-forming) activity
ND439_12145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND439_12150	COG5544	Lipoprotein
ND439_12180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND439_12190	COG2011	ABC-type metal ion transport system permease component
ND439_12195	COG1464	Belongs to the NlpA lipoprotein family
ND439_12205	COG1720	tRNA m6t6A37 methyltransferase activity
ND439_12210	COG0442	prolyl-tRNA aminoacylation
ND439_12215	COG3015	lipoprotein NlpE involved in copper resistance
ND439_12225	COG4681	YaeQ
ND439_12235	COG4568	rho-dependent transcription termination
ND439_12250	COG0346	lactoylglutathione lyase activity
ND439_12265	COG0825	malonyl-CoA metabolic process
ND439_12270	COG0587	DNA-directed DNA polymerase activity
ND439_12275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND439_12295	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND439_12300	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND439_12310	COG0750	zinc metalloprotease
ND439_12315	COG0575	Belongs to the CDS family
ND439_12335	COG0528	UMP kinase activity
ND439_12340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND439_12355	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND439_12360	COG2171	N-acyltransferase activity
ND439_12375	COG0564	pseudouridine synthase activity
ND439_12380	COG3098	single-species biofilm formation
ND439_12395	COG1611	Belongs to the LOG family
ND439_12405	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND439_12410	COG2363	Small membrane protein
ND439_12415	COG0583	DNA-binding transcription factor activity
ND439_12425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND439_12430	COG2166	iron-sulfur cluster assembly
ND439_12435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND439_12440	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND439_12460	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND439_12465	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND439_12465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND439_12470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND439_12475	COG1074	ATP-dependent DNA helicase activity
ND439_12480	COG1025	Belongs to the peptidase M16 family
ND439_12485	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND439_12490	COG4967	type IV pilus modification protein PilV
ND439_12515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND439_12520	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND439_12530	COG3066	DNA modification
ND439_12535	COG0861	Integral membrane protein TerC family
ND439_12540	COG0667	Aldo Keto reductase
ND439_12545	COG0477	Major facilitator Superfamily
ND439_12550	COG0318	PFAM AMP-dependent synthetase and ligase
ND439_12550	COG0204	Acyl-transferase
ND439_12555	COG1609	Transcriptional regulator
ND439_12565	COG0583	DNA-binding transcription factor activity
ND439_12570	COG0583	DNA-binding transcription factor activity
ND439_12625	COG2165	general secretion pathway protein
ND439_12635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND439_12665	COG1127	ABC transporter
ND439_12670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND439_12680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND439_12690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND439_12695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND439_12700	COG4974	Belongs to the 'phage' integrase family
ND439_12705	COG0716	FMN binding
ND439_12715	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND439_12725	COG1272	protein, Hemolysin III
ND439_12745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND439_12750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND439_12755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND439_12760	COG0006	proline dipeptidase activity
ND439_12770	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND439_12780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND439_12785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND439_12790	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND439_12805	COG1279	arginine transmembrane transporter activity
ND439_12815	COG0191	fructose-bisphosphate aldolase activity
ND439_12820	COG0126	phosphoglycerate kinase activity
ND439_12825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND439_12830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND439_12840	COG1166	arginine decarboxylase activity
ND439_12845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND439_12860	COG0640	Transcriptional regulator
ND439_12865	COG3091	SprT-like family
ND439_12870	COG2356	endonuclease I
ND439_12875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND439_12880	COG0189	ligase activity
ND439_12885	COG1678	Uncharacterized ACR, COG1678
ND439_12890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND439_12895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND439_12905	COG2805	Type II/IV secretion system protein
ND439_12910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND439_12915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND439_12920	COG0762	integral membrane protein
ND439_12925	COG1872	DUF167
ND439_12930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND439_12935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND439_12950	COG3171	Protein conserved in bacteria
ND439_12960	COG1194	a g-specific adenine glycosylase
ND439_12965	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND439_12970	COG0741	lytic transglycosylase activity
ND439_13040	COG0583	DNA-binding transcription factor activity
ND439_13055	COG3730	PTS system glucitol sorbitol-specific
ND439_13060	COG3732	PTS system glucitol sorbitol-specific
ND439_13065	COG3731	PTS system glucitol sorbitol-specific IIA component
ND439_13070	COG1028	Short-chain dehydrogenase reductase Sdr
ND439_13075	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND439_13080	COG1349	DNA-binding transcription factor activity
ND439_13090	COG1105	Belongs to the carbohydrate kinase PfkB family
ND439_13095	COG1882	Formate acetyltransferase
ND439_13100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND439_13105	COG0814	amino acid
ND439_13120	COG1028	Short-chain dehydrogenase reductase Sdr
ND439_13125	COG1535	isochorismatase
ND439_13125	COG3433	isochorismatase activity
ND439_13130	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND439_13135	COG1169	isochorismate synthase
ND439_13140	COG4592	Periplasmic binding protein
ND439_13150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND439_13155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND439_13160	COG1120	ATPase activity
ND439_13170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND439_13175	COG3251	PFAM MbtH domain protein
ND439_13185	COG4774	siderophore transport
ND439_13190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND439_13265	COG0848	biopolymer transport protein
ND439_13270	COG0811	peptide transport
ND439_13275	COG0626	cystathionine gamma-synthase activity
ND439_13280	COG0586	Pfam SNARE associated Golgi protein
ND439_13285	COG2207	Transcriptional regulator
ND439_13290	COG1979	alcohol dehydrogenase
ND439_13295	COG0656	L-ascorbic acid biosynthetic process
ND439_13305	COG2132	Multicopper oxidase
ND439_13315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ND439_13320	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND439_13325	COG0583	DNA-binding transcription factor activity
ND439_13330	COG0187	DNA topoisomerase II activity
ND439_13335	COG3150	esterase
ND439_13340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND439_13345	COG3151	Protein conserved in bacteria
ND439_13350	COG0494	nUDIX hydrolase
ND439_13355	COG1538	Outer membrane efflux protein
ND439_13360	COG5463	Belongs to the UPF0441 family
ND439_13365	COG0754	glutathionylspermidine amidase activity
ND439_13370	COG3384	dioxygenase
ND439_13375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND439_13385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND439_13385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND439_13395	COG3025	triphosphatase activity
ND439_13400	COG4991	sh3 domain protein
ND439_13405	COG0617	tRNA 3'-terminal CCA addition
ND439_13410	COG1968	undecaprenyl-diphosphatase activity
ND439_13415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND439_13420	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND439_13425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND439_13430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND439_13435	COG0358	DNA primase activity
ND439_13500	COG0463	Glycosyl transferase, family 2
ND439_13520	COG3210	domain, Protein
ND439_13525	COG2831	hemolysin activation secretion protein
ND439_13530	COG1902	pentaerythritol trinitrate reductase activity
ND439_13530	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND439_13545	COG1451	nucleotide metabolic process
ND439_13550	COG0673	inositol 2-dehydrogenase activity
ND439_13555	COG0861	Integral membrane protein TerC family
ND439_13560	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND439_13570	COG2721	sulfolactate sulfo-lyase activity
ND439_13585	COG2271	Major facilitator Superfamily
ND439_13600	COG0586	Pfam SNARE associated Golgi protein
ND439_13615	COG4575	ribosome binding
ND439_13620	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND439_13630	COG2259	Doxx family
ND439_13635	COG0583	DNA-binding transcription factor activity
ND439_13640	COG1741	Belongs to the pirin family
ND439_13655	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ND439_13670	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND439_13675	COG2823	Periplasmic or secreted lipoprotein
ND439_13680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND439_13685	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND439_13690	COG5002	protein histidine kinase activity
ND439_13690	COG2198	Histidine kinase
ND439_13690	COG0784	Response regulator, receiver
ND439_13700	COG1242	4 iron, 4 sulfur cluster binding
ND439_13705	COG0067	glutamate synthase
ND439_13705	COG0070	glutamate synthase
ND439_13705	COG0069	glutamate synthase activity
ND439_13710	COG0493	'glutamate synthase
ND439_13720	COG2969	positive regulation of protein catabolic process
ND439_13725	COG0625	glutathione transferase activity
ND439_13730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND439_13735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND439_13740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND439_13745	COG3105	Protein conserved in bacteria
ND439_13750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND439_13760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND439_13765	COG5007	Belongs to the BolA IbaG family
ND439_13770	COG3113	response to antibiotic
ND439_13775	COG2854	intermembrane phospholipid transfer
ND439_13780	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND439_13785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND439_13790	COG1127	ABC transporter
ND439_13795	COG0530	calcium, potassium:sodium antiporter activity
ND439_13800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND439_13800	COG0517	IMP dehydrogenase activity
ND439_13805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND439_13810	COG3117	lipopolysaccharide transmembrane transporter activity
ND439_13815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND439_13820	COG1137	ATPase activity
ND439_13825	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND439_13845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND439_13850	COG0540	Belongs to the ATCase OTCase family
ND439_13855	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND439_13865	COG0366	Alpha amylase catalytic
ND439_13870	COG1263	PTS System
ND439_13870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND439_13880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND439_13890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND439_13895	COG3783	Cytochrome b(562)
ND439_13900	COG0312	modulator of DNA gyrase
ND439_13905	COG3028	Belongs to the UPF0307 family
ND439_13910	COG2732	(Barnase) inhibitor
ND439_13915	COG4290	ribonuclease
ND439_13925	COG1289	transmembrane transporter activity
ND439_13930	COG1566	PFAM secretion protein HlyD family protein
ND439_13940	COG0583	DNA-binding transcription factor activity
ND439_13945	COG0312	modulator of DNA gyrase
ND439_13950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND439_13955	COG3164	Protein of unknown function
ND439_13965	COG0424	maF-like protein
ND439_13970	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND439_13975	COG1792	Involved in formation and maintenance of cell shape
ND439_13980	COG1077	Cell shape determining protein MreB Mrl
ND439_13985	COG2199	diguanylate cyclase activity
ND439_13985	COG2200	EAL domain
ND439_13990	COG0604	alcohol dehydrogenase
ND439_13995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND439_14000	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND439_14010	COG0511	ligase activity, forming carbon-carbon bonds
ND439_14015	COG0439	Biotin carboxylase
ND439_14020	COG3924	membrane
ND439_14025	COG4145	pantothenate transmembrane transporter activity
ND439_14030	COG2264	protein methyltransferase activity
ND439_14035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND439_14040	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND439_14050	COG1560	Kdo2-lipid A biosynthetic process
ND439_14060	COG1346	cytolysis
ND439_14065	COG1380	Effector of murein hydrolase LrgA
ND439_14070	COG0583	DNA-binding transcription factor activity
ND439_14075	COG0025	NhaP-type Na H and K H
ND439_14080	COG2252	PERMEase
ND439_14095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND439_14100	COG2315	Protein conserved in bacteria
ND439_14105	COG1448	Aminotransferase
ND439_14120	COG0604	alcohol dehydrogenase
ND439_14130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND439_14135	COG0735	belongs to the Fur family
ND439_14140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND439_14145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND439_14150	COG2937	Belongs to the GPAT DAPAT family
ND439_14170	COG4580	involved in the transport of maltose and maltodextrins
ND439_14185	COG2182	Extracellular solute-binding protein
ND439_14190	COG1175	transmembrane transport
ND439_14195	COG3833	ABC-type maltose transport systems, permease component
ND439_14200	COG3223	Belongs to the PsiE family
ND439_14210	COG0527	aspartate kinase activity
ND439_14240	COG1222	aaa ATPase
ND439_14320	COG0583	DNA-binding transcription factor activity
ND439_14350	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND439_14395	COG0138	bifunctional purine biosynthesis protein purh
ND439_14400	COG0151	Belongs to the GarS family
ND439_14420	COG1515	deoxyribonuclease V activity
ND439_14425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND439_14430	COG2816	NAD+ diphosphatase activity
ND439_14435	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND439_14450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND439_14455	COG2104	thiamine diphosphate biosynthetic process
ND439_14460	COG2022	thiamine diphosphate biosynthetic process
ND439_14470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND439_14475	COG0085	RNA polymerase activity
ND439_14480	COG0222	ribosome binding
ND439_14485	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND439_14495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND439_14500	COG0250	Participates in transcription elongation, termination and antitermination
ND439_14545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND439_14570	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND439_14575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND439_14580	COG1739	Uncharacterized protein family UPF0029
ND439_14590	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND439_14590	COG1024	Enoyl-CoA hydratase
ND439_14600	COG0543	2 iron, 2 sulfur cluster binding
ND439_14615	COG0250	Participates in transcription elongation, termination and antitermination
ND439_14635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND439_14640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND439_14645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND439_14650	COG3165	ubiquinone biosynthetic process from chorismate
ND439_14655	COG2226	methyltransferase
ND439_14660	COG1322	Protein conserved in bacteria
ND439_14665	COG0586	Pfam SNARE associated Golgi protein
ND439_14670	COG1966	Carbon starvation protein
ND439_14685	COG0412	Dienelactone hydrolase
ND439_14690	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND439_14695	COG0583	DNA-binding transcription factor activity
ND439_14700	COG0697	spore germination
ND439_14710	COG0584	glycerophosphoryl diester phosphodiesterase
ND439_14715	COG3842	ATPase activity
ND439_14720	COG0395	ABC-type sugar transport system, permease component
ND439_14725	COG1175	transmembrane transport
ND439_14730	COG1653	transport
ND439_14765	COG0410	ABC transporter
ND439_14775	COG4177	L-phenylalanine transmembrane transporter activity
ND439_14795	COG1929	Belongs to the glycerate kinase type-1 family
ND439_14800	COG2610	gluconate transmembrane transporter activity
ND439_14805	COG3835	regulator
ND439_14815	COG2177	Part of the ABC transporter FtsEX involved in
ND439_14820	COG2884	Cell division ATP-binding protein ftsE
ND439_14825	COG0552	protein localization to endoplasmic reticulum
ND439_14825	COG0552	protein localization to endoplasmic reticulum
ND439_14830	COG0742	ribosomal rna small subunit methyltransferase
ND439_14835	COG3776	membrane
ND439_14850	COG3714	YhhN family
ND439_14865	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND439_14875	COG0247	lactate metabolic process
ND439_14885	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND439_14895	COG2271	Major facilitator Superfamily
ND439_14900	COG0584	glycerophosphoryl diester phosphodiesterase
ND439_14905	COG0561	phosphatase activity
ND439_14910	COG2267	carboxylic ester hydrolase activity
ND439_14915	COG1280	lysine exporter protein (LysE YggA)
ND439_14920	COG0514	ATP-dependent DNA helicase (RecQ)
ND439_14925	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND439_14930	COG2050	protein possibly involved in aromatic compounds catabolism
ND439_14950	COG5564	TIM-barrel signal transduction protein
ND439_14955	COG5441	Belongs to the UPF0261 family
ND439_14965	COG0210	DNA helicase
ND439_14970	COG1011	Hydrolase
ND439_14975	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND439_14980	COG3159	Protein conserved in bacteria
ND439_14985	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND439_14990	COG5567	small periplasmic lipoprotein
ND439_15000	COG3072	Adenylate cyclase
ND439_15005	COG0181	hydroxymethylbilane synthase activity
ND439_15010	COG1587	Uroporphyrinogen-III synthase
ND439_15015	COG2959	enzyme of heme biosynthesis
ND439_15020	COG3071	HemY protein
ND439_15070	COG2244	polysaccharide biosynthetic process
ND439_15075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND439_15080	COG0456	acetyltransferase
ND439_15085	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND439_15090	COG1088	dTDP-glucose 4,6-dehydratase activity
ND439_15095	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND439_15100	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND439_15105	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND439_15110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND439_15115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND439_15120	COG3118	belongs to the thioredoxin family
ND439_15130	COG0248	Ppx GppA phosphatase
ND439_15140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND439_15155	COG3397	chitin binding
ND439_15165	COG0129	dihydroxy-acid dehydratase activity
ND439_15175	COG3978	acetolactate synthase activity
ND439_15195	COG3085	chromosome segregation
ND439_15200	COG0583	DNA-binding transcription factor activity
ND439_15280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND439_15290	COG0678	peroxiredoxin activity
ND439_15290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND439_15295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND439_15335	COG0165	Argininosuccinate lyase
ND439_15340	COG0137	argininosuccinate synthase activity
ND439_15345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND439_15395	COG0460	homoserine dehydrogenase
ND439_15395	COG0527	aspartate kinase activity
ND439_15400	COG0626	cystathionine gamma-synthase activity
ND439_15405	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND439_15415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND439_15420	COG1609	Transcriptional regulator
ND439_15425	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND439_15430	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND439_15435	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND439_15440	COG1575	Belongs to the MenA family. Type 1 subfamily
ND439_15445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND439_15450	COG3074	FtsZ-dependent cytokinesis
ND439_15455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND439_15460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND439_15465	COG1494	fructose-1,6-bisphosphatase
ND439_15470	COG2814	Major facilitator Superfamily
ND439_15480	COG3152	Membrane
ND439_15495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND439_15505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND439_15510	COG3678	ATP-independent chaperone mediated protein folding
ND439_15515	COG0745	RESPONSE REGULATOR receiver
ND439_15520	COG2205	protein histidine kinase activity
ND439_15525	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND439_15530	COG1045	serine acetyltransferase
ND439_15535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND439_15540	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND439_15545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND439_15550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND439_15555	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND439_15560	COG4942	peptidase
ND439_15565	COG2861	carbohydrate metabolic process
ND439_15580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND439_15585	COG0859	PFAM glycosyl transferase family 9
ND439_15590	COG0859	PFAM glycosyl transferase family 9
ND439_15595	COG1519	Transferase
ND439_15615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND439_15620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND439_15625	COG2003	Belongs to the UPF0758 family
ND439_15630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND439_15635	COG0756	dUTP diphosphatase activity
ND439_15640	COG1309	transcriptional regulator
ND439_15645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND439_15650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND439_15655	COG1561	YicC-like family, N-terminal region
ND439_15695	COG5001	Diguanylate cyclase
ND439_15700	COG1024	Enoyl-CoA hydratase
ND439_15705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND439_15715	COG2860	membrane
ND439_15720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND439_15730	COG1758	RNA polymerase activity
ND439_15735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND439_15740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND439_15745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND439_15750	COG0786	glutamate:sodium symporter activity
ND439_15755	COG2233	PERMEase
ND439_15760	COG2982	Protein involved in outer membrane biogenesis
ND439_15765	COG0456	acetyltransferase
ND439_15780	COG1011	Hydrolase
ND439_15795	COG3852	Histidine kinase
ND439_15805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND439_15815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND439_15820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND439_15820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND439_15825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND439_15830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND439_15835	COG3084	Protein conserved in bacteria
ND439_15845	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND439_15870	COG2186	Transcriptional regulator
ND439_15875	COG1609	Transcriptional regulator
ND439_15880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND439_15890	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND439_15895	COG1129	ABC transporter
ND439_15900	COG1869	D-ribose catabolic process
ND439_15905	COG3158	transport of potassium into the cell
ND439_15910	COG0714	Associated with various cellular activities
ND439_15915	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND439_15925	COG2502	aspartate--ammonia ligase
ND439_15930	COG1522	sequence-specific DNA binding
ND439_15935	COG0716	FMN binding
ND439_15940	COG0445	tRNA wobble uridine modification
ND439_15945	COG0357	Ribosomal RNA small subunit methyltransferase G
ND439_15950	COG3312	ion transport
ND439_15955	COG0356	it plays a direct role in the translocation of protons across the membrane
ND439_15965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND439_15975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND439_15980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND439_15990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND439_16005	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND439_16010	COG0573	inorganic phosphate transmembrane transporter activity
ND439_16015	COG0581	inorganic phosphate transmembrane transporter activity
ND439_16025	COG0704	Plays a role in the regulation of phosphate uptake
ND439_16030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND439_16035	COG0765	amino acid transport
ND439_16040	COG0765	amino acid transport
ND439_16045	COG2252	PERMEase
ND439_16050	COG0840	transmembrane signaling receptor activity
ND439_16060	COG3121	Chaperone
ND439_16075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND439_16080	COG0706	membrane insertase activity
ND439_16090	COG0594	ribonuclease P activity
ND439_16095	COG0230	Belongs to the bacterial ribosomal protein bL34 family