locus-tag	class	description
ND445_00010	COG0460	homoserine dehydrogenase
ND445_00010	COG0527	aspartate kinase activity
ND445_00015	COG0626	cystathionine gamma-synthase activity
ND445_00020	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND445_00030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND445_00035	COG1609	Transcriptional regulator
ND445_00040	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND445_00045	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND445_00050	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND445_00055	COG1575	Belongs to the MenA family. Type 1 subfamily
ND445_00060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND445_00065	COG3074	FtsZ-dependent cytokinesis
ND445_00070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND445_00075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND445_00080	COG1494	fructose-1,6-bisphosphatase
ND445_00085	COG2814	Major facilitator Superfamily
ND445_00095	COG3152	Membrane
ND445_00110	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND445_00120	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND445_00125	COG3678	ATP-independent chaperone mediated protein folding
ND445_00130	COG0745	RESPONSE REGULATOR receiver
ND445_00135	COG2205	protein histidine kinase activity
ND445_00140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND445_00145	COG1045	serine acetyltransferase
ND445_00150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND445_00155	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND445_00160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND445_00165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND445_00170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND445_00175	COG4942	peptidase
ND445_00180	COG2861	carbohydrate metabolic process
ND445_00195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND445_00200	COG0859	PFAM glycosyl transferase family 9
ND445_00205	COG0859	PFAM glycosyl transferase family 9
ND445_00210	COG1519	Transferase
ND445_00230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND445_00235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND445_00240	COG2003	Belongs to the UPF0758 family
ND445_00245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND445_00250	COG0756	dUTP diphosphatase activity
ND445_00255	COG1309	transcriptional regulator
ND445_00260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND445_00265	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND445_00270	COG1561	YicC-like family, N-terminal region
ND445_00285	COG5001	Diguanylate cyclase
ND445_00290	COG1024	Enoyl-CoA hydratase
ND445_00295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND445_00305	COG2860	membrane
ND445_00310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND445_00320	COG1758	RNA polymerase activity
ND445_00325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND445_00330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND445_00335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND445_00340	COG0786	glutamate:sodium symporter activity
ND445_00345	COG2233	PERMEase
ND445_00350	COG2982	Protein involved in outer membrane biogenesis
ND445_00355	COG0456	acetyltransferase
ND445_00370	COG1011	Hydrolase
ND445_00385	COG3852	Histidine kinase
ND445_00395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND445_00405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND445_00410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND445_00410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND445_00415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND445_00420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND445_00425	COG3084	Protein conserved in bacteria
ND445_00435	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND445_00460	COG2186	Transcriptional regulator
ND445_00465	COG1609	Transcriptional regulator
ND445_00470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND445_00480	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND445_00485	COG1129	ABC transporter
ND445_00490	COG1869	D-ribose catabolic process
ND445_00495	COG3158	transport of potassium into the cell
ND445_00500	COG0714	Associated with various cellular activities
ND445_00505	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND445_00515	COG2502	aspartate--ammonia ligase
ND445_00520	COG1522	sequence-specific DNA binding
ND445_00525	COG0716	FMN binding
ND445_00530	COG0445	tRNA wobble uridine modification
ND445_00535	COG0357	Ribosomal RNA small subunit methyltransferase G
ND445_00540	COG3312	ion transport
ND445_00545	COG0356	it plays a direct role in the translocation of protons across the membrane
ND445_00555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND445_00565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND445_00570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND445_00580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND445_00595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND445_00600	COG0573	inorganic phosphate transmembrane transporter activity
ND445_00605	COG0581	inorganic phosphate transmembrane transporter activity
ND445_00615	COG0704	Plays a role in the regulation of phosphate uptake
ND445_00620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND445_00625	COG0765	amino acid transport
ND445_00630	COG0765	amino acid transport
ND445_00635	COG2252	PERMEase
ND445_00640	COG0840	transmembrane signaling receptor activity
ND445_00650	COG3121	Chaperone
ND445_00665	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND445_00670	COG0706	membrane insertase activity
ND445_00680	COG0594	ribonuclease P activity
ND445_00685	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ND445_00695	COG0592	DNA-directed DNA polymerase activity
ND445_00705	COG0187	DNA topoisomerase II activity
ND445_00710	COG0561	phosphatase activity
ND445_00715	COG0823	Involved in the tonB-independent uptake of proteins
ND445_00720	COG5645	(Lipo)protein
ND445_00735	COG0569	domain protein
ND445_00735	COG2985	domain, Protein
ND445_00740	COG3977	Valine--pyruvate aminotransferase
ND445_00745	COG2885	chlorophyll binding
ND445_00765	COG2818	Glycosylase
ND445_00815	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND445_00815	COG2213	PTS system mannitol-specific
ND445_00825	COG3722	fumarate hydratase activity
ND445_00835	COG2258	MOSC domain
ND445_00840	COG0840	transmembrane signaling receptor activity
ND445_00845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND445_00860	COG0437	4 iron, 4 sulfur cluster binding
ND445_00865	COG2864	formate dehydrogenase
ND445_00875	COG1921	L-seryl-tRNASec selenium transferase activity
ND445_00880	COG3276	selenocysteine insertion sequence binding
ND445_00885	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND445_00895	COG3274	enterobacterial common antigen metabolic process
ND445_00905	COG0582	viral genome integration into host DNA
ND445_00940	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND445_00945	COG2986	histidine ammonia-lyase
ND445_00965	COG2194	sulfuric ester hydrolase activity
ND445_00970	COG2197	response regulator
ND445_00975	COG3851	Histidine kinase
ND445_00980	COG2271	Major facilitator Superfamily
ND445_00990	COG0747	negative chemotaxis
ND445_00995	COG0601	transmembrane transport
ND445_01000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND445_01005	COG0444	Belongs to the ABC transporter superfamily
ND445_01010	COG4608	Belongs to the ABC transporter superfamily
ND445_01015	COG2194	sulfuric ester hydrolase activity
ND445_01040	COG1215	transferase activity, transferring glycosyl groups
ND445_01045	COG1215	transferase activity, transferring glycosyl groups
ND445_01050	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND445_01055	COG0457	Tetratricopeptide repeat
ND445_01055	COG3118	belongs to the thioredoxin family
ND445_01060	COG2199	diguanylate cyclase activity
ND445_01060	COG2200	EAL domain
ND445_01065	COG1301	dicarboxylic acid transport
ND445_01070	COG0612	Peptidase, M16
ND445_01075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND445_01080	COG1942	4-Oxalocrotonate Tautomerase
ND445_01085	COG2200	EAL domain
ND445_01090	COG2134	cdp-diacylglycerol pyrophosphatase
ND445_01095	COG1295	ribonuclease BN
ND445_01105	COG1301	dicarboxylic acid transport
ND445_01110	COG0626	cystathionine gamma-synthase activity
ND445_01120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND445_01125	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND445_01130	COG0339	signal peptide processing
ND445_01135	COG0742	ribosomal rna small subunit methyltransferase
ND445_01145	COG0589	response to stress
ND445_01155	COG0306	phosphate transporter
ND445_01160	COG2081	HI0933 family
ND445_01170	COG1247	-acetyltransferase
ND445_01180	COG1741	Belongs to the pirin family
ND445_01185	COG1609	Transcriptional regulator
ND445_01190	COG2610	gluconate transmembrane transporter activity
ND445_01195	COG3265	gluconokinase activity
ND445_01200	COG2095	MarC family integral membrane protein
ND445_01205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND445_01210	COG3275	phosphorelay sensor kinase activity
ND445_01215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND445_01220	COG1523	belongs to the glycosyl hydrolase 13 family
ND445_01225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND445_01230	COG0297	glycogen (starch) synthase activity
ND445_01235	COG0058	SHG alpha-glucan phosphorylase activity
ND445_01240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND445_01245	COG1349	DNA-binding transcription factor activity
ND445_01250	COG0705	Rhomboid family
ND445_01260	COG2909	trisaccharide binding
ND445_01265	COG0058	SHG alpha-glucan phosphorylase activity
ND445_01270	COG1640	4-alpha-glucanotransferase
ND445_01280	COG1040	competence protein
ND445_01285	COG0596	Alpha beta hydrolase
ND445_01305	COG1918	ferrous iron import across plasma membrane
ND445_01310	COG2183	response to ionizing radiation
ND445_01335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND445_01350	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND445_01360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND445_01365	COG1011	Hydrolase
ND445_01375	COG0494	nUDIX hydrolase
ND445_01380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND445_01405	COG4796	Type ii and iii secretion system protein
ND445_01410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND445_01430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND445_01440	COG0180	Tryptophanyl-tRNA synthetase
ND445_01460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND445_01465	COG0402	S-adenosylhomocysteine deaminase activity
ND445_01470	COG0738	Major facilitator superfamily
ND445_01485	COG1609	Transcriptional regulator
ND445_01490	COG1486	melibiose metabolic process
ND445_01495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND445_01510	COG1289	transmembrane transporter activity
ND445_01515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND445_01520	COG1765	OsmC-like protein
ND445_01545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND445_01550	COG3954	Phosphoribulokinase
ND445_01560	COG0429	hydrolase of the alpha beta-hydrolase fold
ND445_01570	COG0859	PFAM glycosyl transferase family 9
ND445_01575	COG1216	Glycosyl transferase, family 2
ND445_01580	COG0488	(ABC) transporter
ND445_01585	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND445_01595	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND445_01600	COG1047	Peptidyl-prolyl cis-trans
ND445_01610	COG0545	Peptidyl-prolyl cis-trans isomerase
ND445_01615	COG2964	Protein conserved in bacteria
ND445_01625	COG2923	Belongs to the DsrF TusC family
ND445_01630	COG2168	tRNA wobble position uridine thiolation
ND445_01635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND445_01640	COG0049	tRNA binding
ND445_01650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND445_01665	COG0051	transcription antitermination factor activity, RNA binding
ND445_01670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND445_01680	COG0089	rRNA binding
ND445_01685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND445_01690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND445_01695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND445_01705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND445_01710	COG0255	Belongs to the universal ribosomal protein uL29 family
ND445_01715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND445_01720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND445_01730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND445_01755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND445_01760	COG1841	ribosomal large subunit assembly
ND445_01765	COG0200	Binds to the 23S rRNA
ND445_01770	COG0201	protein transport
ND445_01775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND445_01780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND445_01790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND445_01800	COG0203	ribosomal protein L17
ND445_01805	COG0789	Transcriptional regulator
ND445_01810	COG3036	rescue of stalled ribosome
ND445_01815	COG1970	mechanosensitive ion channel activity
ND445_01825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND445_01825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND445_01830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND445_01835	COG0242	peptide deformylase activity
ND445_01840	COG0758	DNA mediated transformation
ND445_01845	COG2922	Belongs to the Smg family
ND445_01850	COG0551	DNA topoisomerase type I activity
ND445_01855	COG0009	L-threonylcarbamoyladenylate synthase
ND445_01865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND445_01895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND445_01900	COG3162	membrane
ND445_01905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND445_01910	COG1301	dicarboxylic acid transport
ND445_01920	COG2391	methyltransferase activity
ND445_01925	COG0425	Belongs to the sulfur carrier protein TusA family
ND445_01930	COG1086	Polysaccharide biosynthesis protein
ND445_01935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND445_01940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND445_01945	COG2089	acid synthase
ND445_01965	COG1083	cytidylyl-transferase
ND445_01965	COG2755	lipolytic protein G-D-S-L family
ND445_01970	COG1028	Short-chain dehydrogenase reductase Sdr
ND445_01990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND445_01990	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND445_01995	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ND445_02015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND445_02035	COG1309	transcriptional regulator
ND445_02040	COG4232	protein-disulfide reductase activity
ND445_02050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND445_02080	COG1509	lysine 2,3-aminomutase activity
ND445_02090	COG3397	chitin binding
ND445_02110	COG3188	usher protein
ND445_02130	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND445_02135	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND445_02140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND445_02145	COG1053	succinate dehydrogenase
ND445_02150	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND445_02155	COG1511	domain protein
ND445_02155	COG3264	Mechanosensitive ion channel
ND445_02160	COG0688	phosphatidylethanolamine metabolic process
ND445_02165	COG1162	GTPase activity
ND445_02170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND445_02190	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND445_02195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND445_02195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND445_02200	COG0802	atpase or kinase
ND445_02205	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND445_02215	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND445_02225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND445_02230	COG0330	HflC and HflK could
ND445_02235	COG0330	HflC and HflK could
ND445_02240	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND445_02245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND445_02250	COG1959	2 iron, 2 sulfur cluster binding
ND445_02255	COG0557	exoribonuclease II activity
ND445_02260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND445_02280	COG3121	Chaperone
ND445_02285	COG3188	usher protein
ND445_02305	COG1073	alpha beta
ND445_02315	COG0360	Binds together with S18 to 16S ribosomal RNA
ND445_02320	COG2965	DNA replication, synthesis of RNA primer
ND445_02325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND445_02330	COG0359	binds to the 23S rRNA
ND445_02335	COG3061	Opacity-associated protein A
ND445_02340	COG0545	Peptidyl-prolyl cis-trans isomerase
ND445_02350	COG0737	Belongs to the 5'-nucleotidase family
ND445_02355	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND445_02360	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND445_02370	COG1253	flavin adenine dinucleotide binding
ND445_02375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND445_02380	COG0729	surface antigen
ND445_02385	COG2911	Protein conserved in bacteria
ND445_02390	COG2105	PFAM AIG2 family protein
ND445_02395	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND445_02405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND445_02420	COG3423	Transcriptional regulator
ND445_02435	COG0142	geranyltranstransferase activity
ND445_02450	COG0697	spore germination
ND445_02455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND445_02460	COG0642	Histidine kinase
ND445_02465	COG0745	RESPONSE REGULATOR receiver
ND445_02470	COG2027	D-alanyl-D-alanine carboxypeptidase
ND445_02480	COG1534	Rna-binding protein
ND445_02485	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND445_02495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND445_02500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND445_02505	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND445_02525	COG0195	Participates in both transcription termination and antitermination
ND445_02535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND445_02550	COG1185	polyribonucleotide nucleotidyltransferase activity
ND445_02560	COG0513	Belongs to the DEAD box helicase family
ND445_02565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND445_02580	COG0826	peptidase U32
ND445_02585	COG0826	peptidase U32
ND445_02590	COG3154	lipid carrier protein
ND445_02595	COG3153	acetyltransferase
ND445_02600	COG2827	Endonuclease containing a URI domain
ND445_02605	COG0531	amino acid
ND445_02610	COG1982	Orn Lys Arg decarboxylase major
ND445_02620	COG3787	Belongs to the UPF0306 family
ND445_02625	COG0702	epimerase
ND445_02630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND445_02635	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND445_02640	COG3454	Phosphonate metabolism
ND445_02645	COG4778	phosphonate C-P lyase system protein PhnL
ND445_02650	COG4107	phosphonate C-P lyase system protein PhnK
ND445_02655	COG3627	carbon phosphorus lyase activity
ND445_02660	COG3626	phosphonate metabolism
ND445_02665	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND445_02670	COG3624	Phosphonate C-P lyase system protein PhnG
ND445_02690	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND445_02705	COG2927	DNA polymerase III (CHI subunit)
ND445_02710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND445_02715	COG0795	lipopolysaccharide-transporting ATPase activity
ND445_02720	COG0795	lipopolysaccharide-transporting ATPase activity
ND445_02760	COG3077	Addiction module antitoxin, RelB DinJ family
ND445_02865	COG5492	domain, Protein
ND445_02885	COG3119	arylsulfatase activity
ND445_02890	COG1349	DNA-binding transcription factor activity
ND445_02900	COG2222	sugar isomerase
ND445_02905	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND445_02910	COG3715	PTS system
ND445_02915	COG3716	PTS system mannose fructose sorbose family IID component
ND445_02925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND445_02935	COG1028	Short-chain dehydrogenase reductase Sdr
ND445_02945	COG0641	radical SAM
ND445_02950	COG3119	arylsulfatase activity
ND445_02975	COG0859	PFAM glycosyl transferase family 9
ND445_02990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND445_02995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND445_03005	COG2376	Dihydroxyacetone kinase
ND445_03010	COG1461	Dihydroxyacetone kinase
ND445_03015	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND445_03015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND445_03015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND445_03055	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND445_03070	COG2823	Periplasmic or secreted lipoprotein
ND445_03080	COG4667	esterase of the alpha-beta hydrolase superfamily
ND445_03085	COG0084	hydrolase, TatD family'
ND445_03090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND445_03105	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND445_03115	COG3726	membrane protein affecting hemolysin expression
ND445_03120	COG0560	Phosphoserine phosphatase
ND445_03135	COG0488	(ABC) transporter
ND445_03160	COG0741	lytic transglycosylase activity
ND445_03165	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND445_03170	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND445_03175	COG0406	alpha-ribazole phosphatase activity
ND445_03180	COG3708	Transcriptional regulator
ND445_03180	COG2207	Transcriptional regulator
ND445_03185	COG3045	CreA protein
ND445_03190	COG0745	RESPONSE REGULATOR receiver
ND445_03225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND445_03230	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND445_03235	COG0477	Major facilitator Superfamily
ND445_03245	COG1584	GPR1 FUN34 yaaH family protein
ND445_03250	COG0443	Heat shock 70 kDa protein
ND445_03260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND445_03265	COG0583	DNA-binding transcription factor activity
ND445_03275	COG0196	riboflavin kinase activity
ND445_03285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND445_03290	COG1047	Peptidyl-prolyl cis-trans
ND445_03295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND445_03310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND445_03320	COG2966	Psort location CytoplasmicMembrane, score
ND445_03345	COG2967	ApaG domain
ND445_03350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND445_03355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND445_03365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND445_03375	COG0564	pseudouridine synthase activity
ND445_03380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND445_03385	COG0417	DNA replication proofreading
ND445_03390	COG0586	Pfam SNARE associated Golgi protein
ND445_03400	COG1178	ABC-type Fe3 transport system permease component
ND445_03405	COG4143	(ABC) transporter
ND445_03420	COG2814	Major facilitator Superfamily
ND445_03430	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND445_03435	COG0473	3-isopropylmalate dehydrogenase activity
ND445_03450	COG1022	Amp-dependent synthetase and ligase
ND445_03455	COG0028	Belongs to the TPP enzyme family
ND445_03480	COG0275	rRNA processing
ND445_03485	COG3116	cell division
ND445_03490	COG0768	penicillin binding
ND445_03495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND445_03500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND445_03515	COG0772	Belongs to the SEDS family
ND445_03520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND445_03525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND445_03535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND445_03540	COG0849	cell division
ND445_03545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND445_03570	COG0494	nUDIX hydrolase
ND445_03590	COG0516	GMP reductase activity
ND445_03595	COG1459	type II secretion system
ND445_03600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND445_03605	COG4969	Belongs to the N-Me-Phe pilin family
ND445_03620	COG3725	Membrane protein required for beta-lactamase induction
ND445_03625	COG1113	amino acid transport
ND445_03630	COG2186	Transcriptional regulator
ND445_03635	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND445_03640	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND445_03645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND445_03655	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND445_03660	COG3112	Uncharacterised protein family (UPF0231)
ND445_03675	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND445_03685	COG2132	Multicopper oxidase
ND445_03695	COG0288	reversible hydration of carbon dioxide
ND445_03700	COG1131	(ABC) transporter
ND445_03705	COG0842	Transport permease protein
ND445_03710	COG0726	polysaccharide deacetylase
ND445_03715	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND445_03720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND445_03725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND445_03730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND445_03735	COG0617	tRNA 3'-terminal CCA addition
ND445_03750	COG1489	DNA binding
ND445_03755	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND445_03760	COG1643	Atp-dependent helicase
ND445_03765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND445_03770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND445_03780	COG0316	Belongs to the HesB IscA family
ND445_03785	COG2860	membrane
ND445_03795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND445_03800	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND445_03805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND445_03815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND445_03820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND445_03825	COG3956	TIGRFAM MazG family protein
ND445_03830	COG0504	CTP synthase activity
ND445_03840	COG0602	queuosine metabolic process
ND445_03845	COG0720	synthase
ND445_03850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND445_03860	COG0175	sulfate reduction
ND445_03875	COG2234	aminopeptidase activity
ND445_03880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND445_03880	COG1648	precorrin-2 dehydrogenase activity
ND445_03885	COG0175	sulfate reduction
ND445_03890	COG2895	sulfate adenylyltransferase (ATP) activity
ND445_03895	COG0529	Catalyzes the synthesis of activated sulfate
ND445_03905	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND445_03915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND445_03920	COG0585	pseudouridine synthase activity
ND445_03925	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND445_03935	COG1388	LysM domain
ND445_03935	COG4942	peptidase
ND445_03940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND445_03945	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND445_04015	COG2205	protein histidine kinase activity
ND445_04015	COG0784	Response regulator, receiver
ND445_04035	COG0741	lytic transglycosylase activity
ND445_04165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND445_04185	COG3397	chitin binding
ND445_04195	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ND445_04240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND445_04250	COG3031	protein transport across the cell outer membrane
ND445_04275	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND445_04275	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND445_04290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND445_04295	COG2137	regulation of response to DNA damage stimulus
ND445_04300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND445_04305	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND445_04345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND445_04350	COG1238	metal cluster binding
ND445_04355	COG2918	glutathione biosynthetic process
ND445_04360	COG1854	S-ribosylhomocysteine lyase activity
ND445_04365	COG4536	flavin adenine dinucleotide binding
ND445_04370	COG4137	Cytochrome C assembly protein
ND445_04375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND445_04385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND445_04390	COG0336	Belongs to the RNA methyltransferase TrmD family
ND445_04395	COG0335	large ribosomal subunit rRNA binding
ND445_04400	COG3137	Salt-induced outer membrane protein
ND445_04405	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND445_04410	COG3279	Response regulator of the LytR AlgR family
ND445_04415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND445_04420	COG1605	Chorismate mutase
ND445_04420	COG0287	Prephenate dehydrogenase
ND445_04425	COG0077	Prephenate dehydratase
ND445_04425	COG1605	Chorismate mutase
ND445_04435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND445_04440	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND445_04445	COG0564	pseudouridine synthase activity
ND445_04450	COG1496	oxidoreductase activity
ND445_04455	COG0542	response to heat
ND445_04490	COG3021	interspecies interaction between organisms
ND445_04495	COG0741	lytic transglycosylase activity
ND445_04495	COG1388	LysM domain
ND445_04505	COG2226	methyltransferase
ND445_04515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND445_04525	COG1960	acyl-CoA dehydrogenase activity
ND445_04530	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND445_04535	COG0121	glutamine amidotransferase
ND445_04540	COG3034	peptidoglycan biosynthetic process
ND445_04550	COG1805	sodium ion transport
ND445_04555	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND445_04560	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND445_04565	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND445_04575	COG1477	protein flavinylation
ND445_04580	COG2991	Protein conserved in bacteria
ND445_04590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND445_04595	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND445_04600	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND445_04605	COG1073	alpha beta
ND445_04620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND445_04655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND445_04675	COG4126	flavin adenine dinucleotide binding
ND445_04685	COG2974	May be involved in recombination
ND445_04690	COG1940	carbohydrate kinase activity
ND445_04695	COG0419	ATPase involved in DNA repair
ND445_04700	COG0420	3'-5' exonuclease activity
ND445_04705	COG0745	RESPONSE REGULATOR receiver
ND445_04710	COG5002	protein histidine kinase activity
ND445_04725	COG1113	amino acid transport
ND445_04730	COG0366	Alpha amylase catalytic
ND445_04735	COG0300	oxidoreductase activity
ND445_04740	COG0450	alkyl hydroperoxide reductase
ND445_04745	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND445_04760	COG1862	Preprotein translocase
ND445_04765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND445_04770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND445_04775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND445_04780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND445_04780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND445_04785	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND445_04795	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND445_04800	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND445_04805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND445_04810	COG0142	geranyltranstransferase activity
ND445_04845	COG0693	protein deglycase activity
ND445_04850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND445_04855	COG1666	GTP binding
ND445_04860	COG2814	Major facilitator Superfamily
ND445_04870	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND445_04875	COG1845	cytochrome c oxidase, subunit III
ND445_04880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND445_04885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND445_04895	COG2223	nitrite transmembrane transporter activity
ND445_04900	COG3056	Lipoprotein
ND445_04905	COG0271	Belongs to the BolA IbaG family
ND445_04915	COG0740	serine-type endopeptidase activity
ND445_04920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND445_04925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND445_04930	COG0776	regulation of translation
ND445_04935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND445_04940	COG1555	photosystem II stabilization
ND445_04945	COG0824	Thioesterase
ND445_04950	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND445_04955	COG4533	DNA binding
ND445_04970	COG1522	sequence-specific DNA binding
ND445_04975	COG1132	(ABC) transporter
ND445_04980	COG1132	(ABC) transporter
ND445_04985	COG0347	Belongs to the P(II) protein family
ND445_04990	COG0004	ammonium transporteR
ND445_04995	COG1946	Acyl-CoA thioesterase
ND445_05000	COG3695	enzyme binding
ND445_05025	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND445_05030	COG0254	rRNA binding
ND445_05035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND445_05040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND445_05045	COG1309	transcriptional regulator
ND445_05050	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND445_05055	COG1196	nuclear chromosome segregation
ND445_05055	COG3264	Mechanosensitive ion channel
ND445_05070	COG2832	Protein of unknown function (DUF454)
ND445_05075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND445_05115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND445_05120	COG0326	Molecular chaperone. Has ATPase activity
ND445_05135	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND445_05140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND445_05145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND445_05145	COG4651	solute:proton antiporter activity
ND445_05150	COG0737	Belongs to the 5'-nucleotidase family
ND445_05155	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND445_05160	COG3735	TraB family
ND445_05165	COG2217	Heavy metal translocating P-type atpase
ND445_05170	COG0789	Transcriptional regulator
ND445_05175	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND445_05180	COG0330	HflC and HflK could
ND445_05185	COG3118	belongs to the thioredoxin family
ND445_05190	COG0300	oxidoreductase activity
ND445_05195	COG2755	lipolytic protein G-D-S-L family
ND445_05200	COG4181	ATPase activity
ND445_05205	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND445_05210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND445_05215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND445_05220	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND445_05225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND445_05250	COG3188	usher protein
ND445_05255	COG3121	Chaperone
ND445_05285	COG2501	S4 domain
ND445_05290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND445_05305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND445_05310	COG1393	Belongs to the ArsC family
ND445_05320	COG1022	Amp-dependent synthetase and ligase
ND445_05345	COG3038	cytochrome b561
ND445_05375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND445_05385	COG1215	transferase activity, transferring glycosyl groups
ND445_05405	COG3250	beta-galactosidase activity
ND445_05420	COG1309	transcriptional regulator
ND445_05450	COG2197	response regulator
ND445_05455	COG1278	Cold shock
ND445_05475	COG3706	GGDEF domain
ND445_05485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND445_05495	COG2921	Belongs to the UPF0250 family
ND445_05500	COG1686	Belongs to the peptidase S11 family
ND445_05505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND445_05510	COG0772	Belongs to the SEDS family
ND445_05515	COG0768	penicillin binding
ND445_05520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND445_05525	COG0799	negative regulation of ribosome biogenesis
ND445_05530	COG0582	viral genome integration into host DNA
ND445_05590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND445_05655	COG0305	Participates in initiation and elongation during chromosome replication
ND445_05680	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ND445_05755	COG0616	signal peptide processing
ND445_05795	COG4386	tail sheath protein
ND445_05835	COG3299	homolog of phage Mu protein gp47
ND445_05850	COG5301	cellulose 1,4-beta-cellobiosidase activity
ND445_05860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND445_05865	COG1466	dna polymerase III delta subunit
ND445_05870	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND445_05880	COG2888	peptidyl-tyrosine sulfation
ND445_05885	COG1126	abc transporter atp-binding protein
ND445_05890	COG0765	amino acid transport
ND445_05895	COG0765	amino acid transport
ND445_05905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND445_05910	COG4535	Mg2 and Co2 transporter CorC
ND445_05915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND445_05920	COG1702	phosphate starvation-inducible protein PhoH
ND445_05925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND445_05930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND445_05965	COG0367	asparagine synthase
ND445_05970	COG0647	UMP catabolic process
ND445_05975	COG1846	Transcriptional regulator
ND445_05975	COG1940	carbohydrate kinase activity
ND445_05980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND445_05990	COG1263	PTS System
ND445_05990	COG2190	(PTS) system
ND445_05990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND445_06015	COG0735	belongs to the Fur family
ND445_06025	COG0840	transmembrane signaling receptor activity
ND445_06035	COG0596	Alpha beta hydrolase
ND445_06040	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND445_06045	COG0033	Phosphoglucomutase
ND445_06055	COG0745	RESPONSE REGULATOR receiver
ND445_06060	COG2205	protein histidine kinase activity
ND445_06065	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND445_06070	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND445_06090	COG3272	Protein of unknown function (DUF1722)
ND445_06095	COG0415	Belongs to the DNA photolyase family
ND445_06100	COG5212	phosphodiesterase
ND445_06105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND445_06110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND445_06115	COG1984	allophanate hydrolase subunit 2
ND445_06120	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND445_06155	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND445_06160	COG1053	succinate dehydrogenase
ND445_06165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND445_06170	COG0567	Dehydrogenase, E1 component
ND445_06175	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND445_06180	COG0045	succinate-CoA ligase (ADP-forming) activity
ND445_06185	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND445_06190	COG0737	Belongs to the 5'-nucleotidase family
ND445_06195	COG1271	oxidase subunit
ND445_06200	COG1294	oxidase, subunit
ND445_06205	COG4890	Cyd operon protein YbgT
ND445_06210	COG3790	cyd operon protein YbgE
ND445_06215	COG0824	Thioesterase
ND445_06220	COG0811	peptide transport
ND445_06225	COG0848	biopolymer transport protein
ND445_06230	COG3064	Membrane
ND445_06230	COG3064	Membrane
ND445_06235	COG0823	Involved in the tonB-independent uptake of proteins
ND445_06240	COG2885	chlorophyll binding
ND445_06245	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND445_06285	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND445_06295	COG2205	protein histidine kinase activity
ND445_06295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND445_06305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND445_06310	COG0588	phosphoglycerate mutase activity
ND445_06320	COG2017	converts alpha-aldose to the beta-anomer
ND445_06330	COG1085	galactose-1-phosphate uridylyltransferase
ND445_06335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND445_06350	COG2005	Transcriptional regulator
ND445_06350	COG3585	molybdate ion transport
ND445_06360	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND445_06365	COG4149	molybdate abc transporter
ND445_06375	COG0561	phosphatase activity
ND445_06380	COG2706	6-phosphogluconolactonase activity
ND445_06395	COG0156	8-amino-7-oxononanoate synthase activity
ND445_06400	COG2226	methyltransferase
ND445_06415	COG0556	nucleotide-excision repair
ND445_06420	COG4628	conserved protein (DUF2132)
ND445_06435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND445_06440	COG1120	ATPase activity
ND445_06445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND445_06450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND445_06460	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND445_06465	COG0314	molybdopterin synthase activity
ND445_06470	COG0670	Belongs to the BI1 family
ND445_06475	COG0842	Transport permease protein
ND445_06480	COG0842	Transport permease protein
ND445_06485	COG1131	(ABC) transporter
ND445_06490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND445_06495	COG1309	transcriptional regulator
ND445_06500	COG0513	Belongs to the DEAD box helicase family
ND445_06505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND445_06515	COG1686	Belongs to the peptidase S11 family
ND445_06520	COG0277	FAD linked oxidase domain protein
ND445_06540	COG2261	transglycosylase associated protein
ND445_06550	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND445_06560	COG3639	organic phosphonate transmembrane transporter activity
ND445_06565	COG4807	Protein conserved in bacteria
ND445_06570	COG2897	thiosulfate sulfurtransferase activity
ND445_06575	COG1732	Glycine betaine
ND445_06580	COG1174	glycine betaine transport
ND445_06585	COG1125	glycine betaine transport
ND445_06590	COG1174	glycine betaine transport
ND445_06595	COG0531	amino acid
ND445_06600	COG1982	Orn Lys Arg decarboxylase major
ND445_06610	COG0697	spore germination
ND445_06625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND445_06630	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND445_06635	COG1126	abc transporter atp-binding protein
ND445_06640	COG0765	amino acid transport
ND445_06645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND445_06665	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND445_06670	COG2239	Acts as a magnesium transporter
ND445_06675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND445_06680	COG0488	(ABC) transporter
ND445_06685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND445_06690	COG0303	'Molybdopterin
ND445_06710	COG0583	DNA-binding transcription factor activity
ND445_06715	COG0477	Major facilitator Superfamily
ND445_06720	COG0302	gtp cyclohydrolase
ND445_06725	COG2311	Membrane
ND445_06750	COG2949	membrane
ND445_06755	COG0281	malic enzyme
ND445_06765	COG0583	DNA-binding transcription factor activity
ND445_06775	COG1346	cytolysis
ND445_06780	COG1380	Effector of murein hydrolase LrgA
ND445_06790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND445_06790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND445_06795	COG0489	protein tyrosine kinase activity
ND445_06800	COG0572	uridine kinase
ND445_06805	COG0717	Belongs to the dCTP deaminase family
ND445_06810	COG2982	Protein involved in outer membrane biogenesis
ND445_06815	COG3069	C4-dicarboxylate transmembrane transporter activity
ND445_06820	COG1253	flavin adenine dinucleotide binding
ND445_06825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND445_06830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND445_06835	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND445_06845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND445_06845	COG0140	phosphoribosyl-ATP diphosphatase activity
ND445_06855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND445_06865	COG0131	Imidazoleglycerol-phosphate dehydratase
ND445_06865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND445_06870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND445_06875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND445_06890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND445_06895	COG0625	glutathione transferase activity
ND445_06910	COG0626	cystathionine gamma-synthase activity
ND445_06920	COG1686	Belongs to the peptidase S11 family
ND445_06925	COG1760	l-serine dehydratase
ND445_06930	COG0814	amino acid
ND445_06935	COG1349	DNA-binding transcription factor activity
ND445_06945	COG0671	phosphoesterase, PA-phosphatase related
ND445_06955	COG0569	domain protein
ND445_06955	COG2985	domain, Protein
ND445_06975	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND445_06980	COG3842	ATPase activity
ND445_06985	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND445_06990	COG1177	transmembrane transport
ND445_07005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND445_07010	COG4160	amino acid transport
ND445_07015	COG4215	(ABC) transporter
ND445_07020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND445_07025	COG1126	abc transporter atp-binding protein
ND445_07035	COG0393	Putative heavy-metal-binding
ND445_07040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND445_07045	COG0702	epimerase
ND445_07050	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND445_07055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND445_07060	COG1151	hydroxylamine reductase activity
ND445_07065	COG2431	L-lysine efflux transmembrane transporter activity
ND445_07070	COG3593	DNA synthesis involved in DNA repair
ND445_07075	COG2990	Protein conserved in bacteria
ND445_07080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND445_07090	COG1278	Cold shock
ND445_07095	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND445_07100	COG0542	response to heat
ND445_07105	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND445_07115	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND445_07125	COG0492	ferredoxin-NADP+ reductase activity
ND445_07130	COG1522	sequence-specific DNA binding
ND445_07135	COG1674	ftsk spoiiie
ND445_07135	COG3107	peptidoglycan biosynthetic process
ND445_07140	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND445_07145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND445_07150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND445_07155	COG2814	Major facilitator Superfamily
ND445_07160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND445_07165	COG1882	Formate acetyltransferase
ND445_07170	COG2116	formate transmembrane transporter activity
ND445_07175	COG1944	ATP diphosphatase activity
ND445_07180	COG0252	asparaginase activity
ND445_07190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND445_07200	COG0539	negative regulation of cytoplasmic translation
ND445_07210	COG0658	competence protein
ND445_07210	COG2333	competence protein COMEC
ND445_07220	COG1663	tetraacyldisaccharide 4'-kinase activity
ND445_07225	COG5383	Protein conserved in bacteria
ND445_07235	COG1278	Cold shock
ND445_07240	COG2835	tetraacyldisaccharide 4'-kinase activity
ND445_07245	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND445_07250	COG3173	Aminoglycoside phosphotransferase
ND445_07255	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND445_07260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND445_07265	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND445_07275	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND445_07280	COG2989	Protein conserved in bacteria
ND445_07285	COG3108	Peptidase M15
ND445_07290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND445_07295	COG1448	Aminotransferase
ND445_07310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND445_07315	COG0308	aminopeptidase N
ND445_07320	COG0167	dihydroorotate dehydrogenase activity
ND445_07330	COG3217	Mosc domain protein beta barrel domain protein
ND445_07330	COG0633	Ferredoxin
ND445_07335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND445_07335	COG0116	Belongs to the methyltransferase superfamily
ND445_07340	COG0488	(ABC) transporter
ND445_07345	COG2995	paraquat-inducible protein a
ND445_07350	COG3008	intermembrane lipid transfer
ND445_07350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND445_07355	COG3009	Protein conserved in bacteria
ND445_07360	COG3130	regulation of translation
ND445_07365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND445_07370	COG1067	ATP-dependent peptidase activity
ND445_07375	COG3120	sequence-specific DNA binding
ND445_07385	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND445_07390	COG3070	regulator of competence-specific genes
ND445_07395	COG1289	transmembrane transporter activity
ND445_07400	COG3304	Inner membrane component domain
ND445_07405	COG0210	DNA helicase
ND445_07410	COG1803	Methylglyoxal synthase
ND445_07420	COG1832	CoA-binding protein
ND445_07425	COG3785	DNA binding
ND445_07430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND445_07435	COG1254	Belongs to the acylphosphatase family
ND445_07440	COG2920	part of a sulfur-relay system
ND445_07450	COG0288	reversible hydration of carbon dioxide
ND445_07470	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND445_07475	COG2943	transferase activity, transferring hexosyl groups
ND445_07490	COG0675	Transposase, IS605 OrfB family
ND445_07505	COG1560	Kdo2-lipid A biosynthetic process
ND445_07515	COG0628	permease
ND445_07540	COG0418	dihydroorotase activity
ND445_07545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND445_07555	COG1530	ribonuclease E activity
ND445_07560	COG0564	pseudouridine synthase activity
ND445_07565	COG0424	maF-like protein
ND445_07570	COG1399	metal-binding, possibly nucleic acid-binding protein
ND445_07575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND445_07585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND445_07590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND445_07600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND445_07605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND445_07610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND445_07615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND445_07620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND445_07625	COG0470	DNA polymerase III
ND445_07630	COG0084	hydrolase, TatD family'
ND445_07635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND445_07635	COG1263	PTS System
ND445_07640	COG0537	adenosine 5'-monophosphoramidase activity
ND445_07645	COG5633	Lipoprotein
ND445_07650	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND445_07665	COG3150	esterase
ND445_07670	COG1252	NADH dehydrogenase
ND445_07675	COG3134	Outer membrane lipoprotein
ND445_07680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND445_07685	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND445_07695	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND445_07715	COG2850	peptidyl-arginine hydroxylation
ND445_07720	COG2205	protein histidine kinase activity
ND445_07725	COG0745	RESPONSE REGULATOR receiver
ND445_07735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND445_07740	COG2915	High frequency lysogenization protein hflD homolog
ND445_07745	COG0482	sulfurtransferase activity
ND445_07755	COG1187	pseudouridine synthase activity
ND445_07760	COG0538	isocitrate dehydrogenase activity
ND445_07765	COG2771	luxR family
ND445_07770	COG3916	Acyl-homoserine-lactone synthase
ND445_07775	COG2723	6-phospho-beta-galactosidase activity
ND445_07785	COG0339	signal peptide processing
ND445_07790	COG0840	transmembrane signaling receptor activity
ND445_07815	COG0675	Transposase, IS605 OrfB family
ND445_07825	COG4565	transcriptional regulatory protein
ND445_07830	COG3290	protein histidine kinase activity
ND445_07835	COG0471	metal ion transport
ND445_07875	COG4977	sequence-specific DNA binding
ND445_07880	COG1702	phosphate starvation-inducible protein PhoH
ND445_07885	COG0387	Pfam Sodium calcium exchanger
ND445_07890	COG2375	cellular response to nickel ion
ND445_07895	COG3850	Histidine kinase
ND445_07905	COG1294	oxidase, subunit
ND445_07910	COG1271	oxidase subunit
ND445_07915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND445_07920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND445_07925	COG3138	arginine N-succinyltransferase
ND445_07935	COG3724	N-succinylarginine dihydrolase activity
ND445_07955	COG1228	amidohydrolase
ND445_07965	COG0402	S-adenosylhomocysteine deaminase activity
ND445_07985	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND445_07990	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND445_07995	COG3383	formate dehydrogenase (NAD+) activity
ND445_08000	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND445_08005	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND445_08015	COG3260	NADH ubiquinone oxidoreductase 20
ND445_08020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND445_08025	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND445_08025	COG3261	NADH dehydrogenase
ND445_08030	COG0650	Formate hydrogenlyase subunit 4
ND445_08035	COG0651	ATP synthesis coupled electron transport
ND445_08040	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND445_08050	COG0375	protein maturation
ND445_08055	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND445_08060	COG0298	carbon dioxide binding
ND445_08065	COG0409	Hydrogenase expression formation protein
ND445_08070	COG0309	Hydrogenase expression formation protein (HypE)
ND445_08105	COG2207	Transcriptional regulator
ND445_08105	COG3708	Transcriptional regulator
ND445_08110	COG0012	GTP binding
ND445_08120	COG0193	aminoacyl-tRNA hydrolase activity
ND445_08130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND445_08140	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND445_08145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND445_08150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND445_08155	COG2890	protein-(glutamine-N5) methyltransferase activity
ND445_08170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND445_08175	COG0659	secondary active sulfate transmembrane transporter activity
ND445_08180	COG3706	GGDEF domain
ND445_08205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND445_08215	COG3381	protein complex oligomerization
ND445_08235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND445_08245	COG0673	inositol 2-dehydrogenase activity
ND445_08250	COG0728	peptidoglycan biosynthetic process
ND445_08275	COG3102	Protein conserved in bacteria
ND445_08280	COG3142	Participates in the control of copper homeostasis
ND445_08295	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND445_08300	COG1801	Protein of unknown function DUF72
ND445_08310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND445_08315	COG0494	nUDIX hydrolase
ND445_08325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND445_08335	COG2255	four-way junction helicase activity
ND445_08340	COG3104	oligopeptide transport
ND445_08345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND445_08350	COG1121	(ABC) transporter
ND445_08355	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND445_08360	COG0739	heme binding
ND445_08365	COG1560	Kdo2-lipid A biosynthetic process
ND445_08370	COG0469	pyruvate kinase activity
ND445_08375	COG1737	Transcriptional regulator
ND445_08380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND445_08385	COG0800	Aldolase
ND445_08395	COG2076	Multidrug Resistance protein
ND445_08400	COG0251	oxidation-reduction process
ND445_08405	COG1199	ATP-dependent helicase activity
ND445_08410	COG1214	PFAM Peptidase M22, glycoprotease
ND445_08415	COG3065	identical protein binding
ND445_08420	COG0318	PFAM AMP-dependent synthetase and ligase
ND445_08425	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND445_08430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND445_08435	COG2894	cell division
ND445_08440	COG0850	regulation of cytokinetic process
ND445_08445	COG3100	YcgL domain-containing protein
ND445_08450	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND445_08455	COG2983	Belongs to the UPF0260 family
ND445_08475	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND445_08485	COG2719	SpoVR family
ND445_08490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND445_08495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND445_08500	COG2814	Major facilitator Superfamily
ND445_08510	COG2199	diguanylate cyclase activity
ND445_08510	COG2200	EAL domain
ND445_08510	COG2202	Pas domain
ND445_08530	COG2718	Belongs to the UPF0229 family
ND445_08535	COG2766	serine protein kinase
ND445_08545	COG3713	MltA-interacting MipA family protein
ND445_08550	COG2194	sulfuric ester hydrolase activity
ND445_08565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND445_08570	COG3139	Protein of unknown function (DUF1315)
ND445_08575	COG1335	isochorismatase
ND445_08580	COG0252	asparaginase activity
ND445_08585	COG0616	signal peptide processing
ND445_08590	COG0778	Nitroreductase
ND445_08600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND445_08610	COG0494	nUDIX hydrolase
ND445_08615	COG0708	Exodeoxyribonuclease III
ND445_08645	COG0788	formyltetrahydrofolate deformylase activity
ND445_08655	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND445_08660	COG0745	RESPONSE REGULATOR receiver
ND445_08680	COG1012	belongs to the aldehyde dehydrogenase family
ND445_08680	COG1454	alcohol dehydrogenase
ND445_08690	COG2095	MarC family integral membrane protein
ND445_08695	COG4166	transmembrane transport
ND445_08710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND445_08725	COG3099	Belongs to the UPF0263 family
ND445_08730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND445_08750	COG2350	Protein conserved in bacteria
ND445_08765	COG3710	Transcriptional regulator
ND445_08800	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND445_08825	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND445_08830	COG3047	cAMP biosynthetic process
ND445_08845	COG0133	tryptophan synthase activity
ND445_08850	COG0135	phosphoribosylanthranilate isomerase activity
ND445_08850	COG0134	indole-3-glycerol-phosphate synthase activity
ND445_08860	COG0512	Glutamine amidotransferase of anthranilate synthase
ND445_08870	COG0613	PHP domain protein
ND445_08875	COG0009	L-threonylcarbamoyladenylate synthase
ND445_08895	COG1187	pseudouridine synthase activity
ND445_08905	COG1028	Short-chain dehydrogenase reductase Sdr
ND445_08910	COG0616	signal peptide processing
ND445_08925	COG0583	DNA-binding transcription factor activity
ND445_08940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND445_08950	COG0671	phosphoesterase, PA-phosphatase related
ND445_08955	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND445_08960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND445_08980	COG0023	Translation Initiation Factor
ND445_08990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND445_08995	COG5002	protein histidine kinase activity
ND445_08995	COG5001	Diguanylate cyclase
ND445_08995	COG3447	MASE1 domain protein
ND445_09000	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND445_09005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND445_09015	COG4659	FMN binding
ND445_09025	COG3708	Transcriptional regulator
ND445_09025	COG2207	Transcriptional regulator
ND445_09040	COG4657	Part of a membrane complex involved in electron transport
ND445_09050	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND445_09060	COG0673	inositol 2-dehydrogenase activity
ND445_09065	COG0385	Bile acid
ND445_09070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND445_09075	COG5339	Protein conserved in bacteria
ND445_09080	COG1482	cell wall glycoprotein biosynthetic process
ND445_09085	COG0114	fumarate hydratase activity
ND445_09095	COG1940	carbohydrate kinase activity
ND445_09100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND445_09120	COG1742	UPF0060 membrane protein
ND445_09125	COG4221	oxidoreductase activity
ND445_09130	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND445_09150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND445_09190	COG1011	Hydrolase
ND445_09200	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND445_09205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND445_09210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND445_09215	COG0589	response to stress
ND445_09245	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND445_09250	COG3623	hexulose-6-phosphate isomerase
ND445_09255	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND445_09260	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND445_09270	COG0531	amino acid
ND445_09280	COG0745	RESPONSE REGULATOR receiver
ND445_09285	COG2205	protein histidine kinase activity
ND445_09300	COG2207	Transcriptional regulator
ND445_09305	COG1881	PFAM PEBP family protein
ND445_09315	COG3591	Belongs to the peptidase S1B family
ND445_09320	COG1643	Atp-dependent helicase
ND445_09325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND445_09330	COG3784	Protein of unknown function (DUF1318)
ND445_09345	COG2911	Protein conserved in bacteria
ND445_09350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND445_09355	COG3187	Heat shock protein
ND445_09360	COG3042	response to heat
ND445_09365	COG1285	pathogenesis
ND445_09375	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND445_09375	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND445_09375	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND445_09375	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND445_09390	COG4166	transmembrane transport
ND445_09395	COG2866	Carboxypeptidase
ND445_09400	COG4948	Mandelate Racemase Muconate Lactonizing
ND445_09405	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND445_09415	COG5642	Protein of unknown function (DUF2384)
ND445_09420	COG5654	RES domain protein
ND445_09425	COG3768	UPF0283 membrane protein
ND445_09430	COG3106	COG3106 Predicted ATPase
ND445_09440	COG1983	PspC domain protein
ND445_09450	COG1842	Phage shock protein A
ND445_09455	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND445_09470	COG4166	transmembrane transport
ND445_09480	COG4171	peptide transport system, permease
ND445_09485	COG4172	Belongs to the ABC transporter superfamily
ND445_09490	COG4172	Belongs to the ABC transporter superfamily
ND445_09500	COG3104	oligopeptide transport
ND445_09510	COG0484	heat shock protein binding
ND445_09555	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND445_09560	COG3133	Outer membrane lipoprotein
ND445_09565	COG1846	Transcriptional regulator
ND445_09575	COG4989	oxidoreductase activity
ND445_09580	COG3313	Fe-S protein
ND445_09585	COG2194	sulfuric ester hydrolase activity
ND445_09590	COG1309	transcriptional regulator
ND445_09595	COG1902	pentaerythritol trinitrate reductase activity
ND445_09610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND445_09615	COG0791	NLP P60 protein
ND445_09620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND445_09630	COG1609	Transcriptional regulator
ND445_09635	COG0583	DNA-binding transcription factor activity
ND445_09640	COG2814	Major facilitator Superfamily
ND445_09645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND445_09650	COG0307	riboflavin synthase, alpha
ND445_09685	COG1376	ErfK ybiS ycfS ynhG family protein
ND445_09685	COG1388	LysM domain
ND445_09690	COG2166	iron-sulfur cluster assembly
ND445_09700	COG0719	Fe-S assembly protein
ND445_09705	COG0396	ATPase activity
ND445_09710	COG0719	Fe-S assembly protein
ND445_09715	COG0316	Belongs to the HesB IscA family
ND445_09720	COG2050	protein possibly involved in aromatic compounds catabolism
ND445_09725	COG0247	lactate metabolic process
ND445_09725	COG0277	FAD linked oxidase domain protein
ND445_09730	COG0628	permease
ND445_09740	COG0574	Belongs to the PEP-utilizing enzyme family
ND445_09740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND445_09745	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND445_09750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND445_09760	COG4771	TonB-dependent receptor
ND445_09765	COG3720	iron ion transport
ND445_09770	COG4558	Periplasmic binding protein
ND445_09775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND445_09780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND445_09790	COG0095	Lipoate-protein ligase
ND445_09795	COG0791	NLP P60 protein
ND445_09800	COG2076	Multidrug Resistance protein
ND445_09805	COG2076	Multidrug Resistance protein
ND445_09810	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND445_09825	COG0463	Glycosyl transferase, family 2
ND445_09830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND445_09840	COG4139	cobalamin transport
ND445_09885	COG2184	nucleotidyltransferase activity
ND445_09900	COG2314	TM2 domain
ND445_09905	COG0776	regulation of translation
ND445_09975	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND445_09980	COG1121	(ABC) transporter
ND445_09985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND445_09990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND445_09995	COG3001	Fructosamine kinase
ND445_10005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND445_10010	COG1988	membrane-bound metal-dependent
ND445_10015	COG1823	symporter activity
ND445_10020	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND445_10030	COG2814	Major facilitator Superfamily
ND445_10040	COG0501	Belongs to the peptidase M48B family
ND445_10045	COG0793	Belongs to the peptidase S41A family
ND445_10055	COG1956	GAF domain-containing protein
ND445_10060	COG2995	paraquat-inducible protein a
ND445_10065	COG3008	intermembrane lipid transfer
ND445_10070	COG3706	GGDEF domain
ND445_10070	COG4251	negative regulation of phosphorylation
ND445_10070	COG5001	Diguanylate cyclase
ND445_10070	COG2203	Gaf domain
ND445_10280	COG3772	lysozyme
ND445_10330	COG1178	ABC-type Fe3 transport system permease component
ND445_10330	COG1674	ftsk spoiiie
ND445_10450	COG1276	copper resistance
ND445_10455	COG2372	response to copper ion
ND445_10460	COG1528	Iron-storage protein
ND445_10480	COG1770	oligopeptidase
ND445_10490	COG3097	Belongs to the UPF0267 family
ND445_10495	COG3141	response to X-ray
ND445_10500	COG0513	Belongs to the DEAD box helicase family
ND445_10520	COG0494	nUDIX hydrolase
ND445_10525	COG1760	l-serine dehydratase
ND445_10530	COG1253	flavin adenine dinucleotide binding
ND445_10535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND445_10535	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND445_10540	COG3715	PTS system
ND445_10545	COG3716	PTS system mannose fructose sorbose family IID component
ND445_10550	COG4811	Protein of unknown function (DUF986)
ND445_10555	COG1971	Probably functions as a manganese efflux pump
ND445_10575	COG1960	acyl-CoA dehydrogenase activity
ND445_10585	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND445_10615	COG2226	methyltransferase
ND445_10620	COG0768	penicillin binding
ND445_10625	COG1496	oxidoreductase activity
ND445_10645	COG1113	amino acid transport
ND445_10680	COG2207	Transcriptional regulator
ND445_10700	COG1132	(ABC) transporter
ND445_10710	COG5001	Diguanylate cyclase
ND445_10710	COG3706	GGDEF domain
ND445_10710	COG2203	Gaf domain
ND445_10710	COG4251	negative regulation of phosphorylation
ND445_10730	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND445_10750	COG1278	Cold shock
ND445_10755	COG1278	Cold shock
ND445_10760	COG1278	Cold shock
ND445_10775	COG1917	Cupin 2, conserved barrel domain protein
ND445_10775	COG2169	Transcriptional regulator
ND445_10780	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND445_10785	COG2723	6-phospho-beta-galactosidase activity
ND445_10790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND445_10795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND445_10800	COG1187	pseudouridine synthase activity
ND445_10810	COG3122	Protein conserved in bacteria
ND445_10815	COG1757	Na H antiporter
ND445_10830	COG2235	arginine
ND445_10845	COG0076	glutamate decarboxylase activity
ND445_10850	COG0531	amino acid
ND445_10885	COG2153	protein acetylation
ND445_10890	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND445_10920	COG0840	transmembrane signaling receptor activity
ND445_10925	COG2801	Transposase and inactivated derivatives
ND445_10945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND445_10950	COG0322	excinuclease ABC activity
ND445_10955	COG2197	response regulator
ND445_10980	COG1113	amino acid transport
ND445_10990	COG0531	amino acid
ND445_10995	COG3710	Transcriptional regulator
ND445_11000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND445_11005	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND445_11005	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND445_11005	COG0506	proline dehydrogenase activity
ND445_11010	COG1126	abc transporter atp-binding protein
ND445_11015	COG0765	amino acid transport
ND445_11020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND445_11025	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND445_11035	COG1191	sigma factor activity
ND445_11075	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND445_11080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND445_11095	COG1677	Flagellar hook-basal body complex protein FliE
ND445_11105	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND445_11110	COG1317	bacterial-type flagellum organization
ND445_11115	COG1157	protein secretion by the type III secretion system
ND445_11130	COG1580	Controls the rotational direction of flagella during chemotaxis
ND445_11210	COG1558	bacterial-type flagellum-dependent cell motility
ND445_11215	COG1815	bacterial-type flagellum-dependent cell motility
ND445_11225	COG2747	anti-sigma28 factor FlgM
ND445_11230	COG3418	PFAM FlgN family protein
ND445_11240	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND445_11245	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND445_11250	COG4935	Belongs to the peptidase S8 family
ND445_11250	COG1404	Belongs to the peptidase S8 family
ND445_11255	COG2197	response regulator
ND445_11270	COG3188	usher protein
ND445_11275	COG3121	Chaperone
ND445_11285	COG3539	Fimbrial protein
ND445_11315	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND445_11320	COG0745	RESPONSE REGULATOR receiver
ND445_11330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND445_11335	COG0840	transmembrane signaling receptor activity
ND445_11340	COG0840	transmembrane signaling receptor activity
ND445_11345	COG0835	chemotaxis
ND445_11350	COG0643	Histidine kinase
ND445_11350	COG2198	Histidine kinase
ND445_11355	COG1360	Flagellar Motor Protein
ND445_11375	COG0589	response to stress
ND445_11380	COG1285	pathogenesis
ND445_11385	COG0840	transmembrane signaling receptor activity
ND445_11405	COG1609	Transcriptional regulator
ND445_11415	COG3321	synthase
ND445_11415	COG1028	Short-chain dehydrogenase reductase Sdr
ND445_11415	COG0604	alcohol dehydrogenase
ND445_11450	COG0582	viral genome integration into host DNA
ND445_11465	COG3423	Transcriptional regulator
ND445_11500	COG3451	type IV secretory pathway VirB4
ND445_11520	COG3736	Type IV secretory pathway, component VirB8
ND445_11535	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ND445_11550	COG4227	nucleotidyltransferase activity
ND445_11610	COG0471	metal ion transport
ND445_11625	COG3051	citrate lyase alpha subunit
ND445_11630	COG2301	Belongs to the HpcH HpaI aldolase family
ND445_11635	COG3052	prosthetic group binding
ND445_11640	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND445_11645	COG3290	protein histidine kinase activity
ND445_11650	COG4565	transcriptional regulatory protein
ND445_11665	COG2271	Major facilitator Superfamily
ND445_11670	COG1840	ABC-type Fe3 transport system, periplasmic component
ND445_11680	COG3842	ATPase activity
ND445_11700	COG1289	transmembrane transporter activity
ND445_11710	COG2925	Exonuclease
ND445_11715	COG0531	amino acid
ND445_11720	COG4771	TonB-dependent receptor
ND445_11730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND445_11740	COG0833	amino acid
ND445_11745	COG0583	DNA-binding transcription factor activity
ND445_11755	COG2855	membrane
ND445_11760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND445_11765	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND445_11765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND445_11765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND445_11770	COG1105	Belongs to the carbohydrate kinase PfkB family
ND445_11785	COG3005	denitrification pathway
ND445_11790	COG0243	molybdopterin cofactor binding
ND445_11810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND445_11820	COG0246	Mannitol dehydrogenase
ND445_11830	COG0523	cobalamin synthesis protein
ND445_11835	COG0671	phosphoesterase, PA-phosphatase related
ND445_11840	COG0791	NLP P60 protein
ND445_11845	COG2200	EAL domain
ND445_11850	COG4166	transmembrane transport
ND445_11855	COG4174	ABC transporter (Permease)
ND445_11860	COG4239	(ABC) transporter, permease
ND445_11865	COG4172	Belongs to the ABC transporter superfamily
ND445_11875	COG2814	Major facilitator Superfamily
ND445_11880	COG1187	pseudouridine synthase activity
ND445_11885	COG1061	Type III restriction enzyme res subunit
ND445_11900	COG3082	Protein of unknown function (DUF1414)
ND445_11905	COG3083	sulfuric ester hydrolase activity
ND445_11930	COG3778	Protein conserved in bacteria
ND445_11935	COG3299	homolog of phage Mu protein gp47
ND445_11980	COG4386	tail sheath protein
ND445_12030	COG1802	Transcriptional regulator
ND445_12030	COG4626	Terminase
ND445_12055	COG1876	peptidase activity
ND445_12085	COG0515	serine threonine protein kinase
ND445_12085	COG2815	serine threonine protein kinase
ND445_12100	COG1403	HNH endonuclease
ND445_12115	COG4725	Belongs to the MT-A70-like family
ND445_12120	COG1802	Transcriptional regulator
ND445_12120	COG4626	Terminase
ND445_12155	COG5532	Uncharacterized conserved protein (DUF2303)
ND445_12160	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND445_12210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND445_12215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND445_12235	COG2223	nitrite transmembrane transporter activity
ND445_12240	COG2198	Histidine kinase
ND445_12240	COG0642	Histidine kinase
ND445_12250	COG2205	protein histidine kinase activity
ND445_12250	COG0784	Response regulator, receiver
ND445_12260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND445_12265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND445_12275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND445_12285	COG4574	serine-type endopeptidase inhibitor activity
ND445_12295	COG2246	polysaccharide biosynthetic process
ND445_12310	COG0814	amino acid
ND445_12335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND445_12340	COG0596	Alpha beta hydrolase
ND445_12345	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND445_12350	COG1169	isochorismate synthase
ND445_12355	COG4575	ribosome binding
ND445_12370	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND445_12375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND445_12385	COG0839	Belongs to the complex I subunit 6 family
ND445_12390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND445_12395	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND445_12400	COG1034	ATP synthesis coupled electron transport
ND445_12420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND445_12425	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND445_12430	COG0583	DNA-binding transcription factor activity
ND445_12435	COG0436	Aminotransferase
ND445_12440	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND445_12445	COG0471	metal ion transport
ND445_12445	COG0490	domain, Protein
ND445_12455	COG3013	Belongs to the UPF0304 family
ND445_12460	COG3092	negative regulation of chromosome organization
ND445_12470	COG0857	belongs to the CobB CobQ family
ND445_12470	COG0280	phosphate acetyltransferase
ND445_12475	COG1609	Transcriptional regulator
ND445_12490	COG3037	sugar-specific permease SgaT UlaA
ND445_12495	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND445_12500	COG0622	Phosphoesterase
ND445_12515	COG0625	glutathione transferase activity
ND445_12520	COG1090	epimerase
ND445_12530	COG4160	amino acid transport
ND445_12535	COG4215	(ABC) transporter
ND445_12550	COG0163	prenyltransferase activity
ND445_12555	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND445_12560	COG1286	toxin biosynthetic process
ND445_12565	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND445_12570	COG0285	dihydrofolate synthase activity
ND445_12580	COG0586	Pfam SNARE associated Golgi protein
ND445_12590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND445_12615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND445_12620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND445_12650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND445_12665	COG3101	peptidyl-lysine hydroxylation
ND445_12670	COG0730	response to heat
ND445_12675	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND445_12685	COG2890	protein-(glutamine-N5) methyltransferase activity
ND445_12690	COG2840	Smr protein MutS2
ND445_12695	COG2062	phosphohistidine phosphatase, SixA
ND445_12700	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND445_12700	COG1024	Enoyl-CoA hydratase
ND445_12705	COG0183	Belongs to the thiolase family
ND445_12710	COG3691	Protein conserved in bacteria
ND445_12725	COG4235	cytochrome complex assembly
ND445_12725	COG3088	subunit of a heme lyase
ND445_12730	COG4235	cytochrome complex assembly
ND445_12730	COG3088	subunit of a heme lyase
ND445_12735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND445_12740	COG1138	Cytochrome C-type biogenesis protein
ND445_12745	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND445_12750	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND445_12755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND445_12760	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND445_12775	COG0582	viral genome integration into host DNA
ND445_12780	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ND445_12835	COG2824	Alkylphosphonate utilization operon protein PhnA
ND445_12840	COG2951	lytic endotransglycosylase activity
ND445_12845	COG1598	PFAM Uncharacterised protein family UPF0150
ND445_12855	COG3038	cytochrome b561
ND445_12860	COG0436	Aminotransferase
ND445_12870	COG3275	phosphorelay sensor kinase activity
ND445_12875	COG3279	Response regulator of the LytR AlgR family
ND445_12880	COG2223	nitrite transmembrane transporter activity
ND445_12885	COG0837	glucose binding
ND445_12905	COG1914	H( )-stimulated, divalent metal cation uptake system
ND445_12910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND445_12970	COG3530	Putative quorum-sensing-regulated virulence factor
ND445_12975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND445_12985	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND445_12995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND445_13010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND445_13020	COG4208	sulfate ABC transporter
ND445_13025	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND445_13030	COG4150	thiosulfate binding
ND445_13040	COG1737	Transcriptional regulator
ND445_13045	COG2731	YhcH YjgK YiaL family protein
ND445_13060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND445_13065	COG2837	iron assimilation
ND445_13075	COG3111	PFAM Bacterial OB fold (BOF) protein
ND445_13135	COG1671	Belongs to the UPF0178 family
ND445_13140	COG0281	malic enzyme
ND445_13140	COG0280	phosphate acetyltransferase
ND445_13145	COG0494	nUDIX hydrolase
ND445_13150	COG3005	denitrification pathway
ND445_13155	COG3043	anaerobic respiration
ND445_13160	COG0243	molybdopterin cofactor binding
ND445_13165	COG3062	negative regulation of establishment of protein localization
ND445_13170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND445_13170	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND445_13175	COG2197	response regulator
ND445_13185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND445_13195	COG1605	Chorismate mutase
ND445_13200	COG1393	Belongs to the ArsC family
ND445_13205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND445_13210	COG1876	peptidase activity
ND445_13220	COG0400	carboxylic ester hydrolase activity
ND445_13240	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND445_13245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND445_13250	COG2716	regulation of RNA biosynthetic process
ND445_13255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND445_13260	COG0628	permease
ND445_13265	COG4783	chaperone-mediated protein folding
ND445_13270	COG1393	Belongs to the ArsC family
ND445_13275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND445_13280	COG2233	PERMEase
ND445_13285	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND445_13290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND445_13295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND445_13300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND445_13310	COG0581	inorganic phosphate transmembrane transporter activity
ND445_13315	COG0573	inorganic phosphate transmembrane transporter activity
ND445_13320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND445_13335	COG2239	Acts as a magnesium transporter
ND445_13340	COG0443	Heat shock 70 kDa protein
ND445_13350	COG3121	Chaperone
ND445_13370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND445_13380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND445_13385	COG0477	Major facilitator Superfamily
ND445_13390	COG2205	protein histidine kinase activity
ND445_13395	COG0745	RESPONSE REGULATOR receiver
ND445_13400	COG3422	double-strand break repair
ND445_13405	COG0826	peptidase U32
ND445_13410	COG1597	lipid kinase activity
ND445_13425	COG0351	phosphomethylpyrimidine kinase
ND445_13440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND445_13440	COG0519	Catalyzes the synthesis of GMP from XMP
ND445_13445	COG0516	GMP reductase activity
ND445_13445	COG0517	IMP dehydrogenase activity
ND445_13450	COG1570	exodeoxyribonuclease VII activity
ND445_13455	COG1645	bacterial-type flagellum-dependent swarming motility
ND445_13465	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND445_13470	COG2976	Protein conserved in bacteria
ND445_13475	COG0124	histidyl-tRNA synthetase
ND445_13495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND445_13510	COG4953	penicillin-binding protein 1C
ND445_13515	COG2373	Large extracellular alpha-helical protein
ND445_13530	COG2975	iron-sulfur cluster assembly
ND445_13535	COG0633	Ferredoxin
ND445_13540	COG0443	Heat shock 70 kDa protein
ND445_13555	COG0822	iron-sulfur transferase activity
ND445_13565	COG1959	2 iron, 2 sulfur cluster binding
ND445_13570	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND445_13580	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND445_13585	COG3683	transport system, periplasmic component
ND445_13590	COG3711	transcriptional antiterminator
ND445_13595	COG2814	Major facilitator Superfamily
ND445_13605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND445_13605	COG1017	nitric oxide dioxygenase activity
ND445_13610	COG2188	Transcriptional regulator
ND445_13620	COG3457	Alanine racemase
ND445_13625	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND445_13640	COG0347	Belongs to the P(II) protein family
ND445_13645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND445_13645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND445_13650	COG2204	response regulator
ND445_13655	COG3170	Tfp pilus assembly protein FimV
ND445_13660	COG2205	protein histidine kinase activity
ND445_13675	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND445_13685	COG0560	Phosphoserine phosphatase
ND445_13690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND445_13690	COG1263	PTS System
ND445_13700	COG1737	Transcriptional regulator
ND445_13705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND445_13715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND445_13725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND445_13740	COG0481	GTPase activity
ND445_13745	COG3086	response to oxidative stress
ND445_13755	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND445_13765	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND445_13775	COG0513	Belongs to the DEAD box helicase family
ND445_13790	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND445_13800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND445_13805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND445_13810	COG0497	DNA recombination
ND445_13815	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND445_13825	COG2867	negative regulation of translational initiation
ND445_13830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND445_13840	COG0582	viral genome integration into host DNA
ND445_13870	COG3596	GTP binding
ND445_13875	COG2378	regulation of single-species biofilm formation
ND445_13885	COG2378	regulation of single-species biofilm formation
ND445_13910	COG2003	Belongs to the UPF0758 family
ND445_13965	COG3121	Chaperone
ND445_13970	COG3188	usher protein
ND445_13995	COG0583	DNA-binding transcription factor activity
ND445_14070	COG1069	ribulokinase activity
ND445_14080	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND445_14085	COG1129	ABC transporter
ND445_14105	COG1620	l-lactate permease
ND445_14110	COG1304	FMN binding
ND445_14115	COG0579	oxidoreductase
ND445_14120	COG1278	Cold shock
ND445_14150	COG1780	Probably involved in ribonucleotide reductase function
ND445_14155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND445_14165	COG4175	Glycine betaine
ND445_14170	COG4176	ABC-type proline glycine betaine transport system permease component
ND445_14175	COG2113	Glycine betaine
ND445_14185	COG2814	Major facilitator Superfamily
ND445_14190	COG1846	Transcriptional regulator
ND445_14200	COG1566	PFAM secretion protein HlyD family protein
ND445_14205	COG2814	Major facilitator Superfamily
ND445_14210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND445_14215	COG3118	belongs to the thioredoxin family
ND445_14220	COG3148	PFAM DTW domain containing protein
ND445_14225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND445_14225	COG0045	succinate-CoA ligase (ADP-forming) activity
ND445_14225	COG1042	CoA-binding domain protein
ND445_14230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND445_14235	COG5544	Lipoprotein
ND445_14260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND445_14270	COG2011	ABC-type metal ion transport system permease component
ND445_14275	COG1464	Belongs to the NlpA lipoprotein family
ND445_14285	COG1720	tRNA m6t6A37 methyltransferase activity
ND445_14290	COG0442	prolyl-tRNA aminoacylation
ND445_14295	COG3015	lipoprotein NlpE involved in copper resistance
ND445_14305	COG4681	YaeQ
ND445_14315	COG4568	rho-dependent transcription termination
ND445_14330	COG0346	lactoylglutathione lyase activity
ND445_14345	COG0825	malonyl-CoA metabolic process
ND445_14350	COG0587	DNA-directed DNA polymerase activity
ND445_14355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND445_14375	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND445_14380	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND445_14390	COG0750	zinc metalloprotease
ND445_14395	COG0575	Belongs to the CDS family
ND445_14415	COG0528	UMP kinase activity
ND445_14420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND445_14435	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND445_14440	COG2171	N-acyltransferase activity
ND445_14455	COG0564	pseudouridine synthase activity
ND445_14460	COG3098	single-species biofilm formation
ND445_14475	COG1611	Belongs to the LOG family
ND445_14485	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND445_14490	COG2363	Small membrane protein
ND445_14495	COG0583	DNA-binding transcription factor activity
ND445_14505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND445_14510	COG2166	iron-sulfur cluster assembly
ND445_14515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND445_14520	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND445_14540	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND445_14545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND445_14545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND445_14550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND445_14555	COG1074	ATP-dependent DNA helicase activity
ND445_14560	COG1025	Belongs to the peptidase M16 family
ND445_14565	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND445_14570	COG4967	type IV pilus modification protein PilV
ND445_14595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND445_14600	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND445_14610	COG3066	DNA modification
ND445_14615	COG0861	Integral membrane protein TerC family
ND445_14620	COG0667	Aldo Keto reductase
ND445_14625	COG0477	Major facilitator Superfamily
ND445_14630	COG0204	Acyl-transferase
ND445_14630	COG0318	PFAM AMP-dependent synthetase and ligase
ND445_14635	COG1609	Transcriptional regulator
ND445_14645	COG0583	DNA-binding transcription factor activity
ND445_14650	COG0583	DNA-binding transcription factor activity
ND445_14705	COG2165	general secretion pathway protein
ND445_14715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND445_14745	COG1127	ABC transporter
ND445_14750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND445_14760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND445_14770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND445_14775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND445_14780	COG4974	Belongs to the 'phage' integrase family
ND445_14785	COG0716	FMN binding
ND445_14795	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND445_14805	COG1272	protein, Hemolysin III
ND445_14825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND445_14830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND445_14835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND445_14840	COG0006	proline dipeptidase activity
ND445_14850	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND445_14860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND445_14865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND445_14870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND445_14885	COG1279	arginine transmembrane transporter activity
ND445_14895	COG0191	fructose-bisphosphate aldolase activity
ND445_14900	COG0126	phosphoglycerate kinase activity
ND445_14905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND445_14910	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND445_14920	COG1166	arginine decarboxylase activity
ND445_14925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND445_14940	COG0640	Transcriptional regulator
ND445_14945	COG3091	SprT-like family
ND445_14950	COG2356	endonuclease I
ND445_14955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND445_14960	COG0189	ligase activity
ND445_14965	COG1678	Uncharacterized ACR, COG1678
ND445_14970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND445_14975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND445_14985	COG2805	Type II/IV secretion system protein
ND445_14990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND445_14995	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND445_15000	COG0762	integral membrane protein
ND445_15005	COG1872	DUF167
ND445_15010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND445_15015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND445_15030	COG3171	Protein conserved in bacteria
ND445_15040	COG1194	a g-specific adenine glycosylase
ND445_15045	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND445_15050	COG0741	lytic transglycosylase activity
ND445_15095	COG1105	Belongs to the carbohydrate kinase PfkB family
ND445_15100	COG1882	Formate acetyltransferase
ND445_15105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND445_15110	COG0814	amino acid
ND445_15125	COG1028	Short-chain dehydrogenase reductase Sdr
ND445_15130	COG1535	isochorismatase
ND445_15130	COG3433	isochorismatase activity
ND445_15135	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND445_15140	COG1169	isochorismate synthase
ND445_15145	COG4592	Periplasmic binding protein
ND445_15155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND445_15160	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND445_15165	COG1120	ATPase activity
ND445_15175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND445_15180	COG3251	PFAM MbtH domain protein
ND445_15190	COG4774	siderophore transport
ND445_15195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND445_15220	COG4964	Belongs to the GSP D family
ND445_15280	COG0848	biopolymer transport protein
ND445_15285	COG0811	peptide transport
ND445_15290	COG0626	cystathionine gamma-synthase activity
ND445_15295	COG0586	Pfam SNARE associated Golgi protein
ND445_15300	COG2207	Transcriptional regulator
ND445_15305	COG1979	alcohol dehydrogenase
ND445_15310	COG0656	L-ascorbic acid biosynthetic process
ND445_15320	COG2132	Multicopper oxidase
ND445_15335	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND445_15340	COG0583	DNA-binding transcription factor activity
ND445_15345	COG0187	DNA topoisomerase II activity
ND445_15350	COG3150	esterase
ND445_15355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND445_15360	COG3151	Protein conserved in bacteria
ND445_15365	COG0494	nUDIX hydrolase
ND445_15370	COG1538	Outer membrane efflux protein
ND445_15375	COG5463	Belongs to the UPF0441 family
ND445_15380	COG0754	glutathionylspermidine amidase activity
ND445_15385	COG3384	dioxygenase
ND445_15390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND445_15405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND445_15405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND445_15415	COG3025	triphosphatase activity
ND445_15420	COG4991	sh3 domain protein
ND445_15425	COG0617	tRNA 3'-terminal CCA addition
ND445_15430	COG1968	undecaprenyl-diphosphatase activity
ND445_15435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND445_15440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND445_15445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND445_15450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND445_15455	COG0358	DNA primase activity
ND445_15485	COG1028	Short-chain dehydrogenase reductase Sdr
ND445_15515	COG0463	Glycosyl transferase, family 2
ND445_15550	COG3210	domain, Protein
ND445_15555	COG3210	domain, Protein
ND445_15565	COG2831	hemolysin activation secretion protein
ND445_15570	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND445_15570	COG1902	pentaerythritol trinitrate reductase activity
ND445_15585	COG1451	nucleotide metabolic process
ND445_15590	COG0673	inositol 2-dehydrogenase activity
ND445_15595	COG0861	Integral membrane protein TerC family
ND445_15600	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND445_15610	COG2721	sulfolactate sulfo-lyase activity
ND445_15625	COG2271	Major facilitator Superfamily
ND445_15640	COG0586	Pfam SNARE associated Golgi protein
ND445_15655	COG4575	ribosome binding
ND445_15660	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND445_15670	COG2259	Doxx family
ND445_15675	COG0583	DNA-binding transcription factor activity
ND445_15680	COG1741	Belongs to the pirin family
ND445_15695	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ND445_15710	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND445_15715	COG2823	Periplasmic or secreted lipoprotein
ND445_15720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND445_15725	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND445_15730	COG5002	protein histidine kinase activity
ND445_15730	COG2198	Histidine kinase
ND445_15730	COG0784	Response regulator, receiver
ND445_15735	COG1242	4 iron, 4 sulfur cluster binding
ND445_15740	COG0067	glutamate synthase
ND445_15740	COG0070	glutamate synthase
ND445_15740	COG0069	glutamate synthase activity
ND445_15745	COG0493	'glutamate synthase
ND445_15755	COG2969	positive regulation of protein catabolic process
ND445_15760	COG0625	glutathione transferase activity
ND445_15765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND445_15770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND445_15775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND445_15780	COG3105	Protein conserved in bacteria
ND445_15785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND445_15795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND445_15800	COG5007	Belongs to the BolA IbaG family
ND445_15805	COG3113	response to antibiotic
ND445_15810	COG2854	intermembrane phospholipid transfer
ND445_15815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND445_15820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND445_15825	COG1127	ABC transporter
ND445_15830	COG0530	calcium, potassium:sodium antiporter activity
ND445_15835	COG0517	IMP dehydrogenase activity
ND445_15835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND445_15840	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND445_15845	COG3117	lipopolysaccharide transmembrane transporter activity
ND445_15850	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND445_15855	COG1137	ATPase activity
ND445_15860	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND445_15880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND445_15885	COG0540	Belongs to the ATCase OTCase family
ND445_15890	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND445_15900	COG0366	Alpha amylase catalytic
ND445_15905	COG1263	PTS System
ND445_15905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND445_15915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND445_15925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND445_15930	COG3783	Cytochrome b(562)
ND445_15935	COG0312	modulator of DNA gyrase
ND445_15940	COG3028	Belongs to the UPF0307 family
ND445_15945	COG2732	(Barnase) inhibitor
ND445_15950	COG4290	ribonuclease
ND445_15960	COG1289	transmembrane transporter activity
ND445_15965	COG1566	PFAM secretion protein HlyD family protein
ND445_15975	COG0583	DNA-binding transcription factor activity
ND445_15980	COG0312	modulator of DNA gyrase
ND445_15985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND445_15990	COG3164	Protein of unknown function
ND445_16000	COG0424	maF-like protein
ND445_16005	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND445_16010	COG1792	Involved in formation and maintenance of cell shape
ND445_16015	COG1077	Cell shape determining protein MreB Mrl
ND445_16020	COG2199	diguanylate cyclase activity
ND445_16020	COG2200	EAL domain
ND445_16025	COG0604	alcohol dehydrogenase
ND445_16030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND445_16035	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND445_16045	COG0511	ligase activity, forming carbon-carbon bonds
ND445_16050	COG0439	Biotin carboxylase
ND445_16055	COG3924	membrane
ND445_16060	COG4145	pantothenate transmembrane transporter activity
ND445_16065	COG2264	protein methyltransferase activity
ND445_16070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND445_16075	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND445_16085	COG1560	Kdo2-lipid A biosynthetic process
ND445_16095	COG1346	cytolysis
ND445_16100	COG1380	Effector of murein hydrolase LrgA
ND445_16105	COG0583	DNA-binding transcription factor activity
ND445_16110	COG0025	NhaP-type Na H and K H
ND445_16115	COG2252	PERMEase
ND445_16130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND445_16135	COG2315	Protein conserved in bacteria
ND445_16140	COG1448	Aminotransferase
ND445_16165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND445_16170	COG0735	belongs to the Fur family
ND445_16175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND445_16180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND445_16185	COG2937	Belongs to the GPAT DAPAT family
ND445_16205	COG4580	involved in the transport of maltose and maltodextrins
ND445_16220	COG2182	Extracellular solute-binding protein
ND445_16225	COG1175	transmembrane transport
ND445_16230	COG3833	ABC-type maltose transport systems, permease component
ND445_16235	COG3223	Belongs to the PsiE family
ND445_16245	COG0527	aspartate kinase activity
ND445_16260	COG3328	transposase activity
ND445_16270	COG3328	transposase activity
ND445_16295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ND445_16375	COG0583	DNA-binding transcription factor activity
ND445_16415	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND445_16455	COG0138	bifunctional purine biosynthesis protein purh
ND445_16460	COG0151	Belongs to the GarS family
ND445_16480	COG1515	deoxyribonuclease V activity
ND445_16485	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND445_16490	COG2816	NAD+ diphosphatase activity
ND445_16495	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND445_16510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND445_16515	COG2104	thiamine diphosphate biosynthetic process
ND445_16520	COG2022	thiamine diphosphate biosynthetic process
ND445_16530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND445_16535	COG0085	RNA polymerase activity
ND445_16540	COG0222	ribosome binding
ND445_16545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND445_16555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND445_16560	COG0250	Participates in transcription elongation, termination and antitermination
ND445_16605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND445_16630	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND445_16635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND445_16640	COG1739	Uncharacterized protein family UPF0029
ND445_16650	COG1024	Enoyl-CoA hydratase
ND445_16650	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND445_16660	COG0543	2 iron, 2 sulfur cluster binding
ND445_16675	COG0250	Participates in transcription elongation, termination and antitermination
ND445_16690	COG0805	protein transport
ND445_16695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND445_16700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND445_16705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND445_16710	COG3165	ubiquinone biosynthetic process from chorismate
ND445_16715	COG2226	methyltransferase
ND445_16720	COG1322	Protein conserved in bacteria
ND445_16725	COG0586	Pfam SNARE associated Golgi protein
ND445_16730	COG1966	Carbon starvation protein
ND445_16745	COG0412	Dienelactone hydrolase
ND445_16750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND445_16755	COG0583	DNA-binding transcription factor activity
ND445_16760	COG0697	spore germination
ND445_16770	COG0584	glycerophosphoryl diester phosphodiesterase
ND445_16780	COG0395	ABC-type sugar transport system, permease component
ND445_16785	COG1175	transmembrane transport
ND445_16790	COG1653	transport
ND445_16825	COG0410	ABC transporter
ND445_16835	COG4177	L-phenylalanine transmembrane transporter activity
ND445_16855	COG1929	Belongs to the glycerate kinase type-1 family
ND445_16860	COG2610	gluconate transmembrane transporter activity
ND445_16865	COG3835	regulator
ND445_16875	COG2177	Part of the ABC transporter FtsEX involved in
ND445_16880	COG2884	Cell division ATP-binding protein ftsE
ND445_16885	COG0552	protein localization to endoplasmic reticulum
ND445_16885	COG0552	protein localization to endoplasmic reticulum
ND445_16890	COG0742	ribosomal rna small subunit methyltransferase
ND445_16895	COG3776	membrane
ND445_16910	COG3714	YhhN family
ND445_16925	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND445_16935	COG0247	lactate metabolic process
ND445_16945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND445_16955	COG2271	Major facilitator Superfamily
ND445_16960	COG0584	glycerophosphoryl diester phosphodiesterase
ND445_16965	COG0561	phosphatase activity
ND445_16970	COG2267	carboxylic ester hydrolase activity
ND445_16975	COG1280	lysine exporter protein (LysE YggA)
ND445_16980	COG0514	ATP-dependent DNA helicase (RecQ)
ND445_16985	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND445_16990	COG2050	protein possibly involved in aromatic compounds catabolism
ND445_17010	COG5564	TIM-barrel signal transduction protein
ND445_17015	COG5441	Belongs to the UPF0261 family
ND445_17025	COG0210	DNA helicase
ND445_17030	COG1011	Hydrolase
ND445_17035	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND445_17040	COG3159	Protein conserved in bacteria
ND445_17045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND445_17050	COG5567	small periplasmic lipoprotein
ND445_17060	COG3072	Adenylate cyclase
ND445_17065	COG0181	hydroxymethylbilane synthase activity
ND445_17070	COG1587	Uroporphyrinogen-III synthase
ND445_17075	COG2959	enzyme of heme biosynthesis
ND445_17080	COG3071	HemY protein
ND445_17130	COG2244	polysaccharide biosynthetic process
ND445_17135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND445_17140	COG0456	acetyltransferase
ND445_17145	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND445_17150	COG1088	dTDP-glucose 4,6-dehydratase activity
ND445_17155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND445_17160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND445_17165	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND445_17170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND445_17175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND445_17180	COG3118	belongs to the thioredoxin family
ND445_17190	COG0248	Ppx GppA phosphatase
ND445_17200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND445_17215	COG3397	chitin binding
ND445_17225	COG0129	dihydroxy-acid dehydratase activity
ND445_17235	COG3978	acetolactate synthase activity
ND445_17255	COG3085	chromosome segregation
ND445_17260	COG0583	DNA-binding transcription factor activity
ND445_17335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND445_17345	COG0678	peroxiredoxin activity
ND445_17345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND445_17350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND445_17385	COG1629	transport
ND445_17390	COG0165	Argininosuccinate lyase
ND445_17395	COG0137	argininosuccinate synthase activity
ND445_17400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND445_17460	COG1192	Involved in chromosome partitioning
ND445_17530	COG2944	sequence-specific DNA binding
ND445_17695	COG3423	Transcriptional regulator
ND445_17760	COG4382	Mu-like prophage protein Gp16
ND445_17815	COG4383	Mu-like prophage protein gp29
ND445_17840	COG4397	Mu-like prophage major head subunit gpT
ND445_17865	COG4386	tail sheath protein
ND445_17915	COG5301	cellulose 1,4-beta-cellobiosidase activity
ND445_17930	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ND445_17945	COG0741	lytic transglycosylase activity
ND445_17960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND445_18065	COG1454	alcohol dehydrogenase