locus-tag	class	description
ND442_00010	COG0592	DNA-directed DNA polymerase activity
ND442_00020	COG0187	DNA topoisomerase II activity
ND442_00025	COG0561	phosphatase activity
ND442_00030	COG0823	Involved in the tonB-independent uptake of proteins
ND442_00035	COG5645	(Lipo)protein
ND442_00050	COG0569	domain protein
ND442_00050	COG2985	domain, Protein
ND442_00055	COG3977	Valine--pyruvate aminotransferase
ND442_00060	COG2885	chlorophyll binding
ND442_00080	COG2818	Glycosylase
ND442_00130	COG2213	PTS system mannitol-specific
ND442_00130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND442_00140	COG3722	fumarate hydratase activity
ND442_00150	COG2258	MOSC domain
ND442_00155	COG0840	transmembrane signaling receptor activity
ND442_00160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND442_00175	COG0437	4 iron, 4 sulfur cluster binding
ND442_00180	COG2864	formate dehydrogenase
ND442_00190	COG1921	L-seryl-tRNASec selenium transferase activity
ND442_00195	COG3276	selenocysteine insertion sequence binding
ND442_00200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND442_00210	COG3274	enterobacterial common antigen metabolic process
ND442_00220	COG0582	viral genome integration into host DNA
ND442_00255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND442_00260	COG2986	histidine ammonia-lyase
ND442_00280	COG2194	sulfuric ester hydrolase activity
ND442_00285	COG2197	response regulator
ND442_00290	COG3851	Histidine kinase
ND442_00295	COG2271	Major facilitator Superfamily
ND442_00305	COG0747	negative chemotaxis
ND442_00310	COG0601	transmembrane transport
ND442_00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND442_00320	COG0444	Belongs to the ABC transporter superfamily
ND442_00325	COG4608	Belongs to the ABC transporter superfamily
ND442_00330	COG2194	sulfuric ester hydrolase activity
ND442_00355	COG1215	transferase activity, transferring glycosyl groups
ND442_00360	COG1215	transferase activity, transferring glycosyl groups
ND442_00365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND442_00370	COG3118	belongs to the thioredoxin family
ND442_00370	COG0457	Tetratricopeptide repeat
ND442_00375	COG2199	diguanylate cyclase activity
ND442_00375	COG2200	EAL domain
ND442_00380	COG1301	dicarboxylic acid transport
ND442_00385	COG0612	Peptidase, M16
ND442_00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND442_00395	COG1942	4-Oxalocrotonate Tautomerase
ND442_00400	COG2200	EAL domain
ND442_00405	COG2134	cdp-diacylglycerol pyrophosphatase
ND442_00410	COG1295	ribonuclease BN
ND442_00420	COG1301	dicarboxylic acid transport
ND442_00425	COG0626	cystathionine gamma-synthase activity
ND442_00440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND442_00445	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND442_00450	COG0339	signal peptide processing
ND442_00455	COG0742	ribosomal rna small subunit methyltransferase
ND442_00465	COG0589	response to stress
ND442_00475	COG0306	phosphate transporter
ND442_00480	COG2081	HI0933 family
ND442_00490	COG1247	-acetyltransferase
ND442_00500	COG1741	Belongs to the pirin family
ND442_00505	COG1609	Transcriptional regulator
ND442_00510	COG2610	gluconate transmembrane transporter activity
ND442_00515	COG3265	gluconokinase activity
ND442_00520	COG2095	MarC family integral membrane protein
ND442_00525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND442_00530	COG3275	phosphorelay sensor kinase activity
ND442_00535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND442_00540	COG1523	belongs to the glycosyl hydrolase 13 family
ND442_00545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND442_00550	COG0297	glycogen (starch) synthase activity
ND442_00555	COG0058	SHG alpha-glucan phosphorylase activity
ND442_00560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND442_00565	COG1349	DNA-binding transcription factor activity
ND442_00570	COG0705	Rhomboid family
ND442_00580	COG2909	trisaccharide binding
ND442_00585	COG0058	SHG alpha-glucan phosphorylase activity
ND442_00590	COG1640	4-alpha-glucanotransferase
ND442_00600	COG1040	competence protein
ND442_00605	COG0596	Alpha beta hydrolase
ND442_00625	COG1918	ferrous iron import across plasma membrane
ND442_00630	COG2183	response to ionizing radiation
ND442_00655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND442_00670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND442_00680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND442_00685	COG1011	Hydrolase
ND442_00695	COG0494	nUDIX hydrolase
ND442_00700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND442_00725	COG4796	Type ii and iii secretion system protein
ND442_00730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND442_00750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND442_00760	COG0180	Tryptophanyl-tRNA synthetase
ND442_00780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND442_00785	COG0402	S-adenosylhomocysteine deaminase activity
ND442_00790	COG0738	Major facilitator superfamily
ND442_00805	COG1609	Transcriptional regulator
ND442_00810	COG1486	melibiose metabolic process
ND442_00815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND442_00830	COG1289	transmembrane transporter activity
ND442_00835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND442_00840	COG1765	OsmC-like protein
ND442_00865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND442_00870	COG3954	Phosphoribulokinase
ND442_00880	COG0429	hydrolase of the alpha beta-hydrolase fold
ND442_00890	COG0859	PFAM glycosyl transferase family 9
ND442_00895	COG1216	Glycosyl transferase, family 2
ND442_00900	COG0488	(ABC) transporter
ND442_00905	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND442_00915	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND442_00920	COG1047	Peptidyl-prolyl cis-trans
ND442_00930	COG0545	Peptidyl-prolyl cis-trans isomerase
ND442_00935	COG2964	Protein conserved in bacteria
ND442_00945	COG2923	Belongs to the DsrF TusC family
ND442_00950	COG2168	tRNA wobble position uridine thiolation
ND442_00955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND442_00960	COG0049	tRNA binding
ND442_00970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND442_00985	COG0051	transcription antitermination factor activity, RNA binding
ND442_00990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND442_01000	COG0089	rRNA binding
ND442_01005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND442_01010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND442_01015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND442_01025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND442_01030	COG0255	Belongs to the universal ribosomal protein uL29 family
ND442_01035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND442_01040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND442_01050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND442_01075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND442_01080	COG1841	ribosomal large subunit assembly
ND442_01085	COG0200	Binds to the 23S rRNA
ND442_01090	COG0201	protein transport
ND442_01095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND442_01100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND442_01110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND442_01120	COG0203	ribosomal protein L17
ND442_01125	COG0789	Transcriptional regulator
ND442_01130	COG3036	rescue of stalled ribosome
ND442_01135	COG1970	mechanosensitive ion channel activity
ND442_01145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND442_01145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND442_01150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND442_01155	COG0242	peptide deformylase activity
ND442_01160	COG0758	DNA mediated transformation
ND442_01165	COG2922	Belongs to the Smg family
ND442_01170	COG0551	DNA topoisomerase type I activity
ND442_01175	COG0009	L-threonylcarbamoyladenylate synthase
ND442_01185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND442_01215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND442_01220	COG3162	membrane
ND442_01225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND442_01230	COG1301	dicarboxylic acid transport
ND442_01240	COG2391	methyltransferase activity
ND442_01245	COG0425	Belongs to the sulfur carrier protein TusA family
ND442_01250	COG1086	Polysaccharide biosynthesis protein
ND442_01255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND442_01260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND442_01265	COG2089	acid synthase
ND442_01285	COG1083	cytidylyl-transferase
ND442_01285	COG2755	lipolytic protein G-D-S-L family
ND442_01290	COG1028	Short-chain dehydrogenase reductase Sdr
ND442_01310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND442_01310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND442_01315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ND442_01335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND442_01355	COG1309	transcriptional regulator
ND442_01360	COG4232	protein-disulfide reductase activity
ND442_01370	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND442_01400	COG1509	lysine 2,3-aminomutase activity
ND442_01410	COG3397	chitin binding
ND442_01430	COG3188	usher protein
ND442_01450	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND442_01455	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND442_01460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND442_01465	COG1053	succinate dehydrogenase
ND442_01470	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND442_01475	COG3264	Mechanosensitive ion channel
ND442_01475	COG1511	domain protein
ND442_01480	COG0688	phosphatidylethanolamine metabolic process
ND442_01485	COG1162	GTPase activity
ND442_01490	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND442_01510	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND442_01515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND442_01515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND442_01520	COG0802	atpase or kinase
ND442_01525	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND442_01535	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND442_01545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND442_01550	COG0330	HflC and HflK could
ND442_01555	COG0330	HflC and HflK could
ND442_01560	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND442_01565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND442_01570	COG1959	2 iron, 2 sulfur cluster binding
ND442_01575	COG0557	exoribonuclease II activity
ND442_01580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND442_01600	COG3121	Chaperone
ND442_01605	COG3188	usher protein
ND442_01625	COG1073	alpha beta
ND442_01635	COG0360	Binds together with S18 to 16S ribosomal RNA
ND442_01640	COG2965	DNA replication, synthesis of RNA primer
ND442_01645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND442_01650	COG0359	binds to the 23S rRNA
ND442_01655	COG3061	Opacity-associated protein A
ND442_01660	COG0545	Peptidyl-prolyl cis-trans isomerase
ND442_01670	COG0737	Belongs to the 5'-nucleotidase family
ND442_01675	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND442_01680	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND442_01690	COG1253	flavin adenine dinucleotide binding
ND442_01695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND442_01700	COG0729	surface antigen
ND442_01705	COG2911	Protein conserved in bacteria
ND442_01710	COG2105	PFAM AIG2 family protein
ND442_01715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND442_01725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND442_01740	COG3423	Transcriptional regulator
ND442_01755	COG0142	geranyltranstransferase activity
ND442_01770	COG0697	spore germination
ND442_01775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND442_01780	COG0642	Histidine kinase
ND442_01785	COG0745	RESPONSE REGULATOR receiver
ND442_01790	COG2027	D-alanyl-D-alanine carboxypeptidase
ND442_01800	COG1534	Rna-binding protein
ND442_01805	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND442_01815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND442_01820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND442_01825	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND442_01845	COG0195	Participates in both transcription termination and antitermination
ND442_01855	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND442_01870	COG1185	polyribonucleotide nucleotidyltransferase activity
ND442_01880	COG0513	Belongs to the DEAD box helicase family
ND442_01885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND442_01900	COG0826	peptidase U32
ND442_01905	COG0826	peptidase U32
ND442_01910	COG3154	lipid carrier protein
ND442_01915	COG3153	acetyltransferase
ND442_01920	COG2827	Endonuclease containing a URI domain
ND442_01925	COG0531	amino acid
ND442_01930	COG1982	Orn Lys Arg decarboxylase major
ND442_01940	COG3787	Belongs to the UPF0306 family
ND442_01945	COG0702	epimerase
ND442_01950	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND442_01955	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND442_01960	COG3454	Phosphonate metabolism
ND442_01965	COG4778	phosphonate C-P lyase system protein PhnL
ND442_01970	COG4107	phosphonate C-P lyase system protein PhnK
ND442_01975	COG3627	carbon phosphorus lyase activity
ND442_01980	COG3626	phosphonate metabolism
ND442_01985	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND442_01990	COG3624	Phosphonate C-P lyase system protein PhnG
ND442_02010	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND442_02025	COG2927	DNA polymerase III (CHI subunit)
ND442_02030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND442_02035	COG0795	lipopolysaccharide-transporting ATPase activity
ND442_02040	COG0795	lipopolysaccharide-transporting ATPase activity
ND442_02080	COG3077	Addiction module antitoxin, RelB DinJ family
ND442_02185	COG5492	domain, Protein
ND442_02205	COG3119	arylsulfatase activity
ND442_02210	COG1349	DNA-binding transcription factor activity
ND442_02220	COG2222	sugar isomerase
ND442_02225	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND442_02230	COG3715	PTS system
ND442_02235	COG3716	PTS system mannose fructose sorbose family IID component
ND442_02245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND442_02255	COG1028	Short-chain dehydrogenase reductase Sdr
ND442_02265	COG0641	radical SAM
ND442_02270	COG3119	arylsulfatase activity
ND442_02295	COG0859	PFAM glycosyl transferase family 9
ND442_02310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND442_02315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND442_02325	COG2376	Dihydroxyacetone kinase
ND442_02330	COG1461	Dihydroxyacetone kinase
ND442_02335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND442_02335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND442_02335	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND442_02375	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND442_02390	COG2823	Periplasmic or secreted lipoprotein
ND442_02400	COG4667	esterase of the alpha-beta hydrolase superfamily
ND442_02405	COG0084	hydrolase, TatD family'
ND442_02410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND442_02425	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND442_02435	COG3726	membrane protein affecting hemolysin expression
ND442_02440	COG0560	Phosphoserine phosphatase
ND442_02455	COG0488	(ABC) transporter
ND442_02480	COG0741	lytic transglycosylase activity
ND442_02485	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND442_02490	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND442_02495	COG0406	alpha-ribazole phosphatase activity
ND442_02500	COG2207	Transcriptional regulator
ND442_02500	COG3708	Transcriptional regulator
ND442_02505	COG3045	CreA protein
ND442_02510	COG0745	RESPONSE REGULATOR receiver
ND442_02545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND442_02550	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND442_02555	COG0477	Major facilitator Superfamily
ND442_02565	COG1584	GPR1 FUN34 yaaH family protein
ND442_02570	COG0443	Heat shock 70 kDa protein
ND442_02580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND442_02585	COG0583	DNA-binding transcription factor activity
ND442_02595	COG0196	riboflavin kinase activity
ND442_02605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND442_02610	COG1047	Peptidyl-prolyl cis-trans
ND442_02615	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND442_02630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND442_02640	COG2966	Psort location CytoplasmicMembrane, score
ND442_02665	COG2967	ApaG domain
ND442_02670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND442_02675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND442_02685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND442_02695	COG0564	pseudouridine synthase activity
ND442_02700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND442_02705	COG0417	DNA replication proofreading
ND442_02710	COG0586	Pfam SNARE associated Golgi protein
ND442_02720	COG1178	ABC-type Fe3 transport system permease component
ND442_02725	COG4143	(ABC) transporter
ND442_02740	COG2814	Major facilitator Superfamily
ND442_02750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND442_02755	COG0473	3-isopropylmalate dehydrogenase activity
ND442_02770	COG1022	Amp-dependent synthetase and ligase
ND442_02775	COG0028	Belongs to the TPP enzyme family
ND442_02800	COG0275	rRNA processing
ND442_02805	COG3116	cell division
ND442_02810	COG0768	penicillin binding
ND442_02815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND442_02820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND442_02835	COG0772	Belongs to the SEDS family
ND442_02840	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND442_02845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND442_02855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND442_02860	COG0849	cell division
ND442_02865	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND442_02890	COG0494	nUDIX hydrolase
ND442_02910	COG0516	GMP reductase activity
ND442_02915	COG1459	type II secretion system
ND442_02920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND442_02925	COG4969	Belongs to the N-Me-Phe pilin family
ND442_02940	COG3725	Membrane protein required for beta-lactamase induction
ND442_02945	COG1113	amino acid transport
ND442_02950	COG2186	Transcriptional regulator
ND442_02955	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND442_02960	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND442_02965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND442_02975	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND442_02980	COG3112	Uncharacterised protein family (UPF0231)
ND442_02995	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND442_03005	COG2132	Multicopper oxidase
ND442_03015	COG0288	reversible hydration of carbon dioxide
ND442_03020	COG1131	(ABC) transporter
ND442_03025	COG0842	Transport permease protein
ND442_03030	COG0726	polysaccharide deacetylase
ND442_03035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND442_03040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND442_03045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND442_03050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND442_03055	COG0617	tRNA 3'-terminal CCA addition
ND442_03070	COG1489	DNA binding
ND442_03075	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND442_03080	COG1643	Atp-dependent helicase
ND442_03085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND442_03090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND442_03100	COG0316	Belongs to the HesB IscA family
ND442_03105	COG2860	membrane
ND442_03115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND442_03120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND442_03125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND442_03135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND442_03140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND442_03145	COG3956	TIGRFAM MazG family protein
ND442_03150	COG0504	CTP synthase activity
ND442_03160	COG0602	queuosine metabolic process
ND442_03165	COG0720	synthase
ND442_03170	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND442_03180	COG0175	sulfate reduction
ND442_03195	COG2234	aminopeptidase activity
ND442_03200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND442_03200	COG1648	precorrin-2 dehydrogenase activity
ND442_03205	COG0175	sulfate reduction
ND442_03210	COG2895	sulfate adenylyltransferase (ATP) activity
ND442_03215	COG0529	Catalyzes the synthesis of activated sulfate
ND442_03225	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND442_03235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND442_03240	COG0585	pseudouridine synthase activity
ND442_03245	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND442_03255	COG1388	LysM domain
ND442_03255	COG4942	peptidase
ND442_03260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND442_03265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND442_03335	COG2205	protein histidine kinase activity
ND442_03335	COG0784	Response regulator, receiver
ND442_03355	COG0741	lytic transglycosylase activity
ND442_03485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND442_03505	COG3397	chitin binding
ND442_03515	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ND442_03560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND442_03570	COG3031	protein transport across the cell outer membrane
ND442_03595	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND442_03595	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND442_03610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND442_03615	COG2137	regulation of response to DNA damage stimulus
ND442_03620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND442_03625	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND442_03655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND442_03660	COG1238	metal cluster binding
ND442_03665	COG2918	glutathione biosynthetic process
ND442_03670	COG1854	S-ribosylhomocysteine lyase activity
ND442_03675	COG4536	flavin adenine dinucleotide binding
ND442_03680	COG4137	Cytochrome C assembly protein
ND442_03685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND442_03695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND442_03700	COG0336	Belongs to the RNA methyltransferase TrmD family
ND442_03705	COG0335	large ribosomal subunit rRNA binding
ND442_03710	COG3137	Salt-induced outer membrane protein
ND442_03715	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND442_03720	COG3279	Response regulator of the LytR AlgR family
ND442_03725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND442_03730	COG1605	Chorismate mutase
ND442_03730	COG0287	Prephenate dehydrogenase
ND442_03735	COG1605	Chorismate mutase
ND442_03735	COG0077	Prephenate dehydratase
ND442_03745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND442_03750	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND442_03755	COG0564	pseudouridine synthase activity
ND442_03760	COG1496	oxidoreductase activity
ND442_03765	COG0542	response to heat
ND442_03800	COG3021	interspecies interaction between organisms
ND442_03805	COG1388	LysM domain
ND442_03805	COG0741	lytic transglycosylase activity
ND442_03815	COG2226	methyltransferase
ND442_03825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND442_03835	COG1960	acyl-CoA dehydrogenase activity
ND442_03840	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND442_03845	COG0121	glutamine amidotransferase
ND442_03850	COG3034	peptidoglycan biosynthetic process
ND442_03860	COG1805	sodium ion transport
ND442_03865	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND442_03870	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND442_03875	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND442_03885	COG1477	protein flavinylation
ND442_03890	COG2991	Protein conserved in bacteria
ND442_03900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND442_03905	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND442_03910	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND442_03915	COG1073	alpha beta
ND442_03930	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND442_03965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND442_03985	COG4126	flavin adenine dinucleotide binding
ND442_03995	COG2974	May be involved in recombination
ND442_04000	COG1940	carbohydrate kinase activity
ND442_04005	COG0419	ATPase involved in DNA repair
ND442_04010	COG0420	3'-5' exonuclease activity
ND442_04015	COG0745	RESPONSE REGULATOR receiver
ND442_04020	COG5002	protein histidine kinase activity
ND442_04035	COG1113	amino acid transport
ND442_04040	COG0366	Alpha amylase catalytic
ND442_04045	COG0300	oxidoreductase activity
ND442_04050	COG0450	alkyl hydroperoxide reductase
ND442_04055	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND442_04070	COG1862	Preprotein translocase
ND442_04075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND442_04080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND442_04085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND442_04090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND442_04090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND442_04095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND442_04105	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND442_04110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND442_04115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND442_04120	COG0142	geranyltranstransferase activity
ND442_04155	COG0693	protein deglycase activity
ND442_04160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND442_04165	COG1666	GTP binding
ND442_04170	COG2814	Major facilitator Superfamily
ND442_04180	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND442_04185	COG1845	cytochrome c oxidase, subunit III
ND442_04190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND442_04195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND442_04205	COG2223	nitrite transmembrane transporter activity
ND442_04210	COG3056	Lipoprotein
ND442_04215	COG0271	Belongs to the BolA IbaG family
ND442_04225	COG0740	serine-type endopeptidase activity
ND442_04230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND442_04235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND442_04240	COG0776	regulation of translation
ND442_04245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND442_04250	COG1555	photosystem II stabilization
ND442_04255	COG0824	Thioesterase
ND442_04260	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND442_04265	COG4533	DNA binding
ND442_04280	COG1522	sequence-specific DNA binding
ND442_04285	COG1132	(ABC) transporter
ND442_04290	COG1132	(ABC) transporter
ND442_04295	COG0347	Belongs to the P(II) protein family
ND442_04300	COG0004	ammonium transporteR
ND442_04305	COG1946	Acyl-CoA thioesterase
ND442_04310	COG3695	enzyme binding
ND442_04335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND442_04340	COG0254	rRNA binding
ND442_04345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND442_04350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND442_04355	COG1309	transcriptional regulator
ND442_04360	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND442_04365	COG1196	nuclear chromosome segregation
ND442_04365	COG3264	Mechanosensitive ion channel
ND442_04380	COG2832	Protein of unknown function (DUF454)
ND442_04385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND442_04425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND442_04430	COG0326	Molecular chaperone. Has ATPase activity
ND442_04445	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND442_04450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND442_04455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND442_04455	COG4651	solute:proton antiporter activity
ND442_04460	COG0737	Belongs to the 5'-nucleotidase family
ND442_04465	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND442_04470	COG3735	TraB family
ND442_04475	COG2217	Heavy metal translocating P-type atpase
ND442_04480	COG0789	Transcriptional regulator
ND442_04485	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND442_04490	COG0330	HflC and HflK could
ND442_04495	COG3118	belongs to the thioredoxin family
ND442_04500	COG0300	oxidoreductase activity
ND442_04505	COG2755	lipolytic protein G-D-S-L family
ND442_04510	COG4181	ATPase activity
ND442_04515	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND442_04520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND442_04525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND442_04530	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND442_04535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND442_04560	COG3188	usher protein
ND442_04565	COG3121	Chaperone
ND442_04595	COG2501	S4 domain
ND442_04600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND442_04615	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND442_04620	COG1393	Belongs to the ArsC family
ND442_04630	COG1022	Amp-dependent synthetase and ligase
ND442_04655	COG3038	cytochrome b561
ND442_04685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND442_04695	COG1215	transferase activity, transferring glycosyl groups
ND442_04715	COG3250	beta-galactosidase activity
ND442_04730	COG1309	transcriptional regulator
ND442_04760	COG2197	response regulator
ND442_04765	COG1278	Cold shock
ND442_04785	COG3706	GGDEF domain
ND442_04795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND442_04805	COG2921	Belongs to the UPF0250 family
ND442_04810	COG1686	Belongs to the peptidase S11 family
ND442_04815	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND442_04820	COG0772	Belongs to the SEDS family
ND442_04825	COG0768	penicillin binding
ND442_04830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND442_04835	COG0799	negative regulation of ribosome biogenesis
ND442_04840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND442_04845	COG1466	dna polymerase III delta subunit
ND442_04850	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND442_04860	COG2888	peptidyl-tyrosine sulfation
ND442_04865	COG1126	abc transporter atp-binding protein
ND442_04870	COG0765	amino acid transport
ND442_04875	COG0765	amino acid transport
ND442_04885	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND442_04890	COG4535	Mg2 and Co2 transporter CorC
ND442_04895	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND442_04900	COG1702	phosphate starvation-inducible protein PhoH
ND442_04905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND442_04910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND442_04945	COG0367	asparagine synthase
ND442_04950	COG0647	UMP catabolic process
ND442_04955	COG1846	Transcriptional regulator
ND442_04955	COG1940	carbohydrate kinase activity
ND442_04960	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND442_04970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND442_04970	COG2190	(PTS) system
ND442_04970	COG1263	PTS System
ND442_04995	COG0735	belongs to the Fur family
ND442_05005	COG0840	transmembrane signaling receptor activity
ND442_05015	COG0596	Alpha beta hydrolase
ND442_05020	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND442_05025	COG0033	Phosphoglucomutase
ND442_05035	COG0745	RESPONSE REGULATOR receiver
ND442_05040	COG2205	protein histidine kinase activity
ND442_05045	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND442_05050	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND442_05070	COG3272	Protein of unknown function (DUF1722)
ND442_05075	COG0415	Belongs to the DNA photolyase family
ND442_05080	COG5212	phosphodiesterase
ND442_05085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND442_05090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND442_05095	COG1984	allophanate hydrolase subunit 2
ND442_05100	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND442_05135	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND442_05140	COG1053	succinate dehydrogenase
ND442_05145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND442_05150	COG0567	Dehydrogenase, E1 component
ND442_05155	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND442_05160	COG0045	succinate-CoA ligase (ADP-forming) activity
ND442_05165	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND442_05170	COG0737	Belongs to the 5'-nucleotidase family
ND442_05175	COG1271	oxidase subunit
ND442_05180	COG1294	oxidase, subunit
ND442_05185	COG4890	Cyd operon protein YbgT
ND442_05190	COG3790	cyd operon protein YbgE
ND442_05195	COG0824	Thioesterase
ND442_05200	COG0811	peptide transport
ND442_05205	COG0848	biopolymer transport protein
ND442_05210	COG3064	Membrane
ND442_05210	COG3064	Membrane
ND442_05215	COG0823	Involved in the tonB-independent uptake of proteins
ND442_05220	COG2885	chlorophyll binding
ND442_05225	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND442_05255	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND442_05265	COG2205	protein histidine kinase activity
ND442_05265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND442_05275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND442_05280	COG0588	phosphoglycerate mutase activity
ND442_05290	COG2017	converts alpha-aldose to the beta-anomer
ND442_05300	COG1085	galactose-1-phosphate uridylyltransferase
ND442_05305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND442_05320	COG3585	molybdate ion transport
ND442_05320	COG2005	Transcriptional regulator
ND442_05330	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND442_05335	COG4149	molybdate abc transporter
ND442_05345	COG0561	phosphatase activity
ND442_05350	COG2706	6-phosphogluconolactonase activity
ND442_05365	COG0156	8-amino-7-oxononanoate synthase activity
ND442_05370	COG2226	methyltransferase
ND442_05385	COG0556	nucleotide-excision repair
ND442_05390	COG4628	conserved protein (DUF2132)
ND442_05405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND442_05410	COG1120	ATPase activity
ND442_05415	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND442_05420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND442_05430	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND442_05435	COG0314	molybdopterin synthase activity
ND442_05440	COG0670	Belongs to the BI1 family
ND442_05445	COG0842	Transport permease protein
ND442_05450	COG0842	Transport permease protein
ND442_05455	COG1131	(ABC) transporter
ND442_05460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND442_05465	COG1309	transcriptional regulator
ND442_05470	COG0513	Belongs to the DEAD box helicase family
ND442_05475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND442_05485	COG1686	Belongs to the peptidase S11 family
ND442_05490	COG0277	FAD linked oxidase domain protein
ND442_05510	COG2261	transglycosylase associated protein
ND442_05520	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND442_05530	COG3639	organic phosphonate transmembrane transporter activity
ND442_05535	COG4807	Protein conserved in bacteria
ND442_05540	COG2897	thiosulfate sulfurtransferase activity
ND442_05545	COG1732	Glycine betaine
ND442_05550	COG1174	glycine betaine transport
ND442_05555	COG1125	glycine betaine transport
ND442_05560	COG1174	glycine betaine transport
ND442_05565	COG0531	amino acid
ND442_05570	COG1982	Orn Lys Arg decarboxylase major
ND442_05580	COG0697	spore germination
ND442_05595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND442_05600	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND442_05605	COG1126	abc transporter atp-binding protein
ND442_05610	COG0765	amino acid transport
ND442_05615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND442_05635	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND442_05640	COG2239	Acts as a magnesium transporter
ND442_05645	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND442_05650	COG0488	(ABC) transporter
ND442_05655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND442_05660	COG0303	'Molybdopterin
ND442_05680	COG0583	DNA-binding transcription factor activity
ND442_05685	COG0477	Major facilitator Superfamily
ND442_05690	COG0302	gtp cyclohydrolase
ND442_05695	COG2311	Membrane
ND442_05720	COG2949	membrane
ND442_05725	COG0281	malic enzyme
ND442_05735	COG0583	DNA-binding transcription factor activity
ND442_05745	COG1346	cytolysis
ND442_05750	COG1380	Effector of murein hydrolase LrgA
ND442_05760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND442_05760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND442_05765	COG0489	protein tyrosine kinase activity
ND442_05770	COG0572	uridine kinase
ND442_05775	COG0717	Belongs to the dCTP deaminase family
ND442_05780	COG2982	Protein involved in outer membrane biogenesis
ND442_05785	COG3069	C4-dicarboxylate transmembrane transporter activity
ND442_05790	COG1253	flavin adenine dinucleotide binding
ND442_05795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND442_05800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND442_05805	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND442_05815	COG0140	phosphoribosyl-ATP diphosphatase activity
ND442_05815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND442_05825	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND442_05835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND442_05835	COG0131	Imidazoleglycerol-phosphate dehydratase
ND442_05840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND442_05845	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND442_05860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND442_05865	COG0625	glutathione transferase activity
ND442_05880	COG0626	cystathionine gamma-synthase activity
ND442_05890	COG1686	Belongs to the peptidase S11 family
ND442_05895	COG1760	l-serine dehydratase
ND442_05900	COG0814	amino acid
ND442_05905	COG1349	DNA-binding transcription factor activity
ND442_05915	COG0671	phosphoesterase, PA-phosphatase related
ND442_05925	COG2985	domain, Protein
ND442_05925	COG0569	domain protein
ND442_05945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND442_05950	COG3842	ATPase activity
ND442_05955	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND442_05960	COG1177	transmembrane transport
ND442_05975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND442_05980	COG4160	amino acid transport
ND442_05985	COG4215	(ABC) transporter
ND442_05990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND442_05995	COG1126	abc transporter atp-binding protein
ND442_06005	COG0393	Putative heavy-metal-binding
ND442_06010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND442_06015	COG0702	epimerase
ND442_06020	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND442_06025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND442_06030	COG1151	hydroxylamine reductase activity
ND442_06035	COG2431	L-lysine efflux transmembrane transporter activity
ND442_06040	COG3593	DNA synthesis involved in DNA repair
ND442_06045	COG2990	Protein conserved in bacteria
ND442_06050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND442_06060	COG1278	Cold shock
ND442_06065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND442_06070	COG0542	response to heat
ND442_06075	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND442_06085	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND442_06095	COG0492	ferredoxin-NADP+ reductase activity
ND442_06100	COG1522	sequence-specific DNA binding
ND442_06105	COG1674	ftsk spoiiie
ND442_06105	COG3107	peptidoglycan biosynthetic process
ND442_06110	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND442_06115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND442_06120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND442_06125	COG2814	Major facilitator Superfamily
ND442_06130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND442_06135	COG1882	Formate acetyltransferase
ND442_06140	COG2116	formate transmembrane transporter activity
ND442_06145	COG1944	ATP diphosphatase activity
ND442_06150	COG0252	asparaginase activity
ND442_06160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND442_06170	COG0539	negative regulation of cytoplasmic translation
ND442_06180	COG2333	competence protein COMEC
ND442_06180	COG0658	competence protein
ND442_06190	COG1663	tetraacyldisaccharide 4'-kinase activity
ND442_06195	COG5383	Protein conserved in bacteria
ND442_06205	COG1278	Cold shock
ND442_06210	COG2835	tetraacyldisaccharide 4'-kinase activity
ND442_06215	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND442_06220	COG3173	Aminoglycoside phosphotransferase
ND442_06225	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND442_06230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND442_06235	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND442_06245	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND442_06250	COG2989	Protein conserved in bacteria
ND442_06255	COG3108	Peptidase M15
ND442_06260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND442_06265	COG1448	Aminotransferase
ND442_06280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND442_06285	COG0308	aminopeptidase N
ND442_06290	COG0167	dihydroorotate dehydrogenase activity
ND442_06300	COG0633	Ferredoxin
ND442_06300	COG3217	Mosc domain protein beta barrel domain protein
ND442_06305	COG0116	Belongs to the methyltransferase superfamily
ND442_06305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND442_06310	COG0488	(ABC) transporter
ND442_06315	COG2995	paraquat-inducible protein a
ND442_06320	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND442_06320	COG3008	intermembrane lipid transfer
ND442_06325	COG3009	Protein conserved in bacteria
ND442_06330	COG3130	regulation of translation
ND442_06335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND442_06340	COG1067	ATP-dependent peptidase activity
ND442_06345	COG3120	sequence-specific DNA binding
ND442_06355	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND442_06360	COG3070	regulator of competence-specific genes
ND442_06365	COG1289	transmembrane transporter activity
ND442_06370	COG3304	Inner membrane component domain
ND442_06375	COG0210	DNA helicase
ND442_06380	COG1803	Methylglyoxal synthase
ND442_06390	COG1832	CoA-binding protein
ND442_06395	COG3785	DNA binding
ND442_06400	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND442_06405	COG1254	Belongs to the acylphosphatase family
ND442_06410	COG2920	part of a sulfur-relay system
ND442_06420	COG0288	reversible hydration of carbon dioxide
ND442_06440	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND442_06445	COG2943	transferase activity, transferring hexosyl groups
ND442_06460	COG0675	Transposase, IS605 OrfB family
ND442_06475	COG1560	Kdo2-lipid A biosynthetic process
ND442_06485	COG0628	permease
ND442_06510	COG0418	dihydroorotase activity
ND442_06515	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND442_06525	COG1530	ribonuclease E activity
ND442_06530	COG0564	pseudouridine synthase activity
ND442_06535	COG0424	maF-like protein
ND442_06540	COG1399	metal-binding, possibly nucleic acid-binding protein
ND442_06545	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND442_06555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND442_06560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND442_06570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND442_06575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND442_06580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND442_06585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND442_06590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND442_06595	COG0470	DNA polymerase III
ND442_06600	COG0084	hydrolase, TatD family'
ND442_06605	COG1263	PTS System
ND442_06605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND442_06610	COG0537	adenosine 5'-monophosphoramidase activity
ND442_06615	COG5633	Lipoprotein
ND442_06620	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND442_06635	COG3150	esterase
ND442_06640	COG1252	NADH dehydrogenase
ND442_06645	COG3134	Outer membrane lipoprotein
ND442_06650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND442_06655	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND442_06665	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND442_06685	COG2850	peptidyl-arginine hydroxylation
ND442_06690	COG2205	protein histidine kinase activity
ND442_06695	COG0745	RESPONSE REGULATOR receiver
ND442_06705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND442_06710	COG2915	High frequency lysogenization protein hflD homolog
ND442_06715	COG0482	sulfurtransferase activity
ND442_06725	COG1187	pseudouridine synthase activity
ND442_06730	COG0538	isocitrate dehydrogenase activity
ND442_06735	COG2771	luxR family
ND442_06740	COG3916	Acyl-homoserine-lactone synthase
ND442_06745	COG2723	6-phospho-beta-galactosidase activity
ND442_06750	COG0339	signal peptide processing
ND442_06755	COG0840	transmembrane signaling receptor activity
ND442_06780	COG0675	Transposase, IS605 OrfB family
ND442_06790	COG4565	transcriptional regulatory protein
ND442_06795	COG3290	protein histidine kinase activity
ND442_06800	COG0471	metal ion transport
ND442_06840	COG4977	sequence-specific DNA binding
ND442_06845	COG1702	phosphate starvation-inducible protein PhoH
ND442_06850	COG0387	Pfam Sodium calcium exchanger
ND442_06855	COG2375	cellular response to nickel ion
ND442_06860	COG3850	Histidine kinase
ND442_06870	COG1294	oxidase, subunit
ND442_06875	COG1271	oxidase subunit
ND442_06880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND442_06885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND442_06890	COG3138	arginine N-succinyltransferase
ND442_06900	COG3724	N-succinylarginine dihydrolase activity
ND442_06920	COG1228	amidohydrolase
ND442_06930	COG0402	S-adenosylhomocysteine deaminase activity
ND442_06950	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND442_06955	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND442_06960	COG3383	formate dehydrogenase (NAD+) activity
ND442_06965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND442_06970	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND442_06980	COG3260	NADH ubiquinone oxidoreductase 20
ND442_06985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND442_06990	COG3261	NADH dehydrogenase
ND442_06990	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND442_06995	COG0650	Formate hydrogenlyase subunit 4
ND442_07000	COG0651	ATP synthesis coupled electron transport
ND442_07005	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND442_07015	COG0375	protein maturation
ND442_07020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND442_07025	COG0298	carbon dioxide binding
ND442_07030	COG0409	Hydrogenase expression formation protein
ND442_07035	COG0309	Hydrogenase expression formation protein (HypE)
ND442_07070	COG2207	Transcriptional regulator
ND442_07070	COG3708	Transcriptional regulator
ND442_07075	COG0012	GTP binding
ND442_07085	COG0193	aminoacyl-tRNA hydrolase activity
ND442_07095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND442_07105	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND442_07110	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND442_07115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND442_07120	COG2890	protein-(glutamine-N5) methyltransferase activity
ND442_07135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND442_07140	COG0659	secondary active sulfate transmembrane transporter activity
ND442_07145	COG3706	GGDEF domain
ND442_07170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND442_07180	COG3381	protein complex oligomerization
ND442_07200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND442_07210	COG0673	inositol 2-dehydrogenase activity
ND442_07215	COG0728	peptidoglycan biosynthetic process
ND442_07240	COG3102	Protein conserved in bacteria
ND442_07245	COG3142	Participates in the control of copper homeostasis
ND442_07260	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND442_07265	COG1801	Protein of unknown function DUF72
ND442_07275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND442_07280	COG0494	nUDIX hydrolase
ND442_07290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND442_07300	COG2255	four-way junction helicase activity
ND442_07305	COG3104	oligopeptide transport
ND442_07310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND442_07315	COG1121	(ABC) transporter
ND442_07320	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND442_07325	COG0739	heme binding
ND442_07330	COG1560	Kdo2-lipid A biosynthetic process
ND442_07335	COG0469	pyruvate kinase activity
ND442_07340	COG1737	Transcriptional regulator
ND442_07345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND442_07350	COG0800	Aldolase
ND442_07360	COG2076	Multidrug Resistance protein
ND442_07365	COG0251	oxidation-reduction process
ND442_07370	COG1199	ATP-dependent helicase activity
ND442_07375	COG1214	PFAM Peptidase M22, glycoprotease
ND442_07380	COG3065	identical protein binding
ND442_07385	COG0318	PFAM AMP-dependent synthetase and ligase
ND442_07390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND442_07395	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND442_07400	COG2894	cell division
ND442_07405	COG0850	regulation of cytokinetic process
ND442_07410	COG3100	YcgL domain-containing protein
ND442_07415	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND442_07420	COG2983	Belongs to the UPF0260 family
ND442_07440	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND442_07450	COG2719	SpoVR family
ND442_07455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND442_07460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND442_07465	COG2814	Major facilitator Superfamily
ND442_07475	COG2199	diguanylate cyclase activity
ND442_07475	COG2200	EAL domain
ND442_07475	COG2202	Pas domain
ND442_07495	COG2718	Belongs to the UPF0229 family
ND442_07500	COG2766	serine protein kinase
ND442_07510	COG3713	MltA-interacting MipA family protein
ND442_07515	COG2194	sulfuric ester hydrolase activity
ND442_07530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND442_07535	COG3139	Protein of unknown function (DUF1315)
ND442_07540	COG1335	isochorismatase
ND442_07545	COG0252	asparaginase activity
ND442_07550	COG0616	signal peptide processing
ND442_07555	COG0778	Nitroreductase
ND442_07565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND442_07575	COG0494	nUDIX hydrolase
ND442_07580	COG0708	Exodeoxyribonuclease III
ND442_07610	COG0788	formyltetrahydrofolate deformylase activity
ND442_07620	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND442_07625	COG0745	RESPONSE REGULATOR receiver
ND442_07645	COG1012	belongs to the aldehyde dehydrogenase family
ND442_07645	COG1454	alcohol dehydrogenase
ND442_07655	COG2095	MarC family integral membrane protein
ND442_07660	COG4166	transmembrane transport
ND442_07675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND442_07690	COG3099	Belongs to the UPF0263 family
ND442_07695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND442_07715	COG2350	Protein conserved in bacteria
ND442_07730	COG3710	Transcriptional regulator
ND442_07765	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND442_07790	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND442_07795	COG3047	cAMP biosynthetic process
ND442_07810	COG0133	tryptophan synthase activity
ND442_07815	COG0135	phosphoribosylanthranilate isomerase activity
ND442_07815	COG0134	indole-3-glycerol-phosphate synthase activity
ND442_07825	COG0512	Glutamine amidotransferase of anthranilate synthase
ND442_07835	COG0613	PHP domain protein
ND442_07840	COG0009	L-threonylcarbamoyladenylate synthase
ND442_07860	COG1187	pseudouridine synthase activity
ND442_07870	COG1028	Short-chain dehydrogenase reductase Sdr
ND442_07875	COG0616	signal peptide processing
ND442_07890	COG0583	DNA-binding transcription factor activity
ND442_07905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND442_07915	COG0671	phosphoesterase, PA-phosphatase related
ND442_07920	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND442_07925	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND442_07945	COG0023	Translation Initiation Factor
ND442_07955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND442_07960	COG3447	MASE1 domain protein
ND442_07960	COG5002	protein histidine kinase activity
ND442_07960	COG5001	Diguanylate cyclase
ND442_07965	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND442_07970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND442_07980	COG4659	FMN binding
ND442_07990	COG3708	Transcriptional regulator
ND442_07990	COG2207	Transcriptional regulator
ND442_08005	COG4657	Part of a membrane complex involved in electron transport
ND442_08015	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND442_08025	COG0673	inositol 2-dehydrogenase activity
ND442_08030	COG0385	Bile acid
ND442_08035	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND442_08040	COG5339	Protein conserved in bacteria
ND442_08045	COG1482	cell wall glycoprotein biosynthetic process
ND442_08050	COG0114	fumarate hydratase activity
ND442_08060	COG1940	carbohydrate kinase activity
ND442_08065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND442_08085	COG1742	UPF0060 membrane protein
ND442_08090	COG4221	oxidoreductase activity
ND442_08095	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND442_08115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND442_08155	COG1011	Hydrolase
ND442_08165	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND442_08170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND442_08175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND442_08180	COG0589	response to stress
ND442_08210	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND442_08215	COG3623	hexulose-6-phosphate isomerase
ND442_08220	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND442_08225	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND442_08235	COG0531	amino acid
ND442_08245	COG0745	RESPONSE REGULATOR receiver
ND442_08250	COG2205	protein histidine kinase activity
ND442_08265	COG2207	Transcriptional regulator
ND442_08270	COG1881	PFAM PEBP family protein
ND442_08280	COG3591	Belongs to the peptidase S1B family
ND442_08285	COG1643	Atp-dependent helicase
ND442_08290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND442_08295	COG3784	Protein of unknown function (DUF1318)
ND442_08310	COG2911	Protein conserved in bacteria
ND442_08315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND442_08320	COG3187	Heat shock protein
ND442_08325	COG3042	response to heat
ND442_08330	COG1285	pathogenesis
ND442_08340	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND442_08340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND442_08340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND442_08340	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND442_08355	COG4166	transmembrane transport
ND442_08360	COG2866	Carboxypeptidase
ND442_08365	COG4948	Mandelate Racemase Muconate Lactonizing
ND442_08370	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND442_08380	COG5642	Protein of unknown function (DUF2384)
ND442_08385	COG5654	RES domain protein
ND442_08390	COG3768	UPF0283 membrane protein
ND442_08395	COG3106	COG3106 Predicted ATPase
ND442_08405	COG1983	PspC domain protein
ND442_08415	COG1842	Phage shock protein A
ND442_08420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND442_08435	COG4166	transmembrane transport
ND442_08445	COG4171	peptide transport system, permease
ND442_08450	COG4172	Belongs to the ABC transporter superfamily
ND442_08455	COG4172	Belongs to the ABC transporter superfamily
ND442_08465	COG3104	oligopeptide transport
ND442_08475	COG0484	heat shock protein binding
ND442_08520	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND442_08525	COG1309	transcriptional regulator
ND442_08530	COG1902	pentaerythritol trinitrate reductase activity
ND442_08545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND442_08550	COG0791	NLP P60 protein
ND442_08555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND442_08565	COG1609	Transcriptional regulator
ND442_08570	COG0583	DNA-binding transcription factor activity
ND442_08575	COG2814	Major facilitator Superfamily
ND442_08580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND442_08585	COG0307	riboflavin synthase, alpha
ND442_08615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ND442_08685	COG4386	tail sheath protein
ND442_08710	COG4397	Mu-like prophage major head subunit gpT
ND442_08735	COG4383	Mu-like prophage protein gp29
ND442_08790	COG4382	Mu-like prophage protein Gp16
ND442_08855	COG3423	Transcriptional regulator
ND442_08870	COG1376	ErfK ybiS ycfS ynhG family protein
ND442_08870	COG1388	LysM domain
ND442_08875	COG2166	iron-sulfur cluster assembly
ND442_08885	COG0719	Fe-S assembly protein
ND442_08890	COG0396	ATPase activity
ND442_08895	COG0719	Fe-S assembly protein
ND442_08900	COG0316	Belongs to the HesB IscA family
ND442_08905	COG2050	protein possibly involved in aromatic compounds catabolism
ND442_08910	COG0247	lactate metabolic process
ND442_08910	COG0277	FAD linked oxidase domain protein
ND442_08915	COG0628	permease
ND442_08925	COG0574	Belongs to the PEP-utilizing enzyme family
ND442_08925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND442_08930	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND442_08935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND442_08945	COG4771	TonB-dependent receptor
ND442_08950	COG3720	iron ion transport
ND442_08955	COG4558	Periplasmic binding protein
ND442_08960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND442_08965	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND442_08975	COG0095	Lipoate-protein ligase
ND442_08980	COG0791	NLP P60 protein
ND442_08985	COG2076	Multidrug Resistance protein
ND442_08990	COG2076	Multidrug Resistance protein
ND442_08995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND442_09010	COG0463	Glycosyl transferase, family 2
ND442_09015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND442_09025	COG4139	cobalamin transport
ND442_09070	COG2184	nucleotidyltransferase activity
ND442_09085	COG2314	TM2 domain
ND442_09090	COG0776	regulation of translation
ND442_09160	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND442_09165	COG1121	(ABC) transporter
ND442_09170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND442_09175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND442_09180	COG3001	Fructosamine kinase
ND442_09190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND442_09195	COG1988	membrane-bound metal-dependent
ND442_09200	COG1823	symporter activity
ND442_09205	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND442_09215	COG2814	Major facilitator Superfamily
ND442_09225	COG0501	Belongs to the peptidase M48B family
ND442_09230	COG0793	Belongs to the peptidase S41A family
ND442_09240	COG1956	GAF domain-containing protein
ND442_09245	COG2995	paraquat-inducible protein a
ND442_09250	COG3008	intermembrane lipid transfer
ND442_09255	COG2203	Gaf domain
ND442_09255	COG3706	GGDEF domain
ND442_09255	COG4251	negative regulation of phosphorylation
ND442_09255	COG5001	Diguanylate cyclase
ND442_09465	COG3772	lysozyme
ND442_09515	COG1674	ftsk spoiiie
ND442_09515	COG1178	ABC-type Fe3 transport system permease component
ND442_09635	COG1276	copper resistance
ND442_09640	COG2372	response to copper ion
ND442_09645	COG1528	Iron-storage protein
ND442_09660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND442_09665	COG1770	oligopeptidase
ND442_09675	COG3097	Belongs to the UPF0267 family
ND442_09680	COG3141	response to X-ray
ND442_09685	COG0513	Belongs to the DEAD box helicase family
ND442_09705	COG0494	nUDIX hydrolase
ND442_09710	COG1760	l-serine dehydratase
ND442_09715	COG1253	flavin adenine dinucleotide binding
ND442_09720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND442_09720	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND442_09725	COG3715	PTS system
ND442_09730	COG3716	PTS system mannose fructose sorbose family IID component
ND442_09735	COG4811	Protein of unknown function (DUF986)
ND442_09740	COG1971	Probably functions as a manganese efflux pump
ND442_09760	COG1960	acyl-CoA dehydrogenase activity
ND442_09770	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND442_09800	COG2226	methyltransferase
ND442_09805	COG0768	penicillin binding
ND442_09810	COG1496	oxidoreductase activity
ND442_09830	COG1113	amino acid transport
ND442_09865	COG2207	Transcriptional regulator
ND442_09885	COG1132	(ABC) transporter
ND442_09895	COG4251	negative regulation of phosphorylation
ND442_09895	COG5001	Diguanylate cyclase
ND442_09895	COG2203	Gaf domain
ND442_09895	COG3706	GGDEF domain
ND442_09915	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND442_09935	COG1278	Cold shock
ND442_09940	COG1278	Cold shock
ND442_09945	COG1278	Cold shock
ND442_09960	COG1917	Cupin 2, conserved barrel domain protein
ND442_09960	COG2169	Transcriptional regulator
ND442_09965	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND442_09970	COG2723	6-phospho-beta-galactosidase activity
ND442_09975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND442_09980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND442_09985	COG1187	pseudouridine synthase activity
ND442_09995	COG3122	Protein conserved in bacteria
ND442_10000	COG1757	Na H antiporter
ND442_10015	COG2235	arginine
ND442_10030	COG0076	glutamate decarboxylase activity
ND442_10035	COG0531	amino acid
ND442_10070	COG2153	protein acetylation
ND442_10075	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND442_10105	COG0840	transmembrane signaling receptor activity
ND442_10110	COG2801	Transposase and inactivated derivatives
ND442_10130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND442_10135	COG0322	excinuclease ABC activity
ND442_10140	COG2197	response regulator
ND442_10165	COG1113	amino acid transport
ND442_10175	COG0531	amino acid
ND442_10180	COG3710	Transcriptional regulator
ND442_10185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND442_10190	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND442_10190	COG0506	proline dehydrogenase activity
ND442_10190	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND442_10195	COG1126	abc transporter atp-binding protein
ND442_10200	COG0765	amino acid transport
ND442_10205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND442_10210	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND442_10220	COG1191	sigma factor activity
ND442_10260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND442_10265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND442_10280	COG1677	Flagellar hook-basal body complex protein FliE
ND442_10290	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND442_10295	COG1317	bacterial-type flagellum organization
ND442_10300	COG1157	protein secretion by the type III secretion system
ND442_10315	COG1580	Controls the rotational direction of flagella during chemotaxis
ND442_10395	COG1558	bacterial-type flagellum-dependent cell motility
ND442_10400	COG1815	bacterial-type flagellum-dependent cell motility
ND442_10410	COG2747	anti-sigma28 factor FlgM
ND442_10415	COG3418	PFAM FlgN family protein
ND442_10425	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND442_10430	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND442_10435	COG1404	Belongs to the peptidase S8 family
ND442_10435	COG4935	Belongs to the peptidase S8 family
ND442_10440	COG2197	response regulator
ND442_10455	COG3188	usher protein
ND442_10460	COG3121	Chaperone
ND442_10470	COG3539	Fimbrial protein
ND442_10500	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND442_10505	COG0745	RESPONSE REGULATOR receiver
ND442_10515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND442_10520	COG0840	transmembrane signaling receptor activity
ND442_10525	COG0840	transmembrane signaling receptor activity
ND442_10530	COG0835	chemotaxis
ND442_10535	COG0643	Histidine kinase
ND442_10535	COG2198	Histidine kinase
ND442_10540	COG1360	Flagellar Motor Protein
ND442_10560	COG0589	response to stress
ND442_10565	COG1285	pathogenesis
ND442_10570	COG0840	transmembrane signaling receptor activity
ND442_10585	COG1609	Transcriptional regulator
ND442_10595	COG0604	alcohol dehydrogenase
ND442_10595	COG1028	Short-chain dehydrogenase reductase Sdr
ND442_10595	COG3321	synthase
ND442_10630	COG0582	viral genome integration into host DNA
ND442_10645	COG3423	Transcriptional regulator
ND442_10680	COG3451	type IV secretory pathway VirB4
ND442_10700	COG3736	Type IV secretory pathway, component VirB8
ND442_10715	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ND442_10730	COG4227	nucleotidyltransferase activity
ND442_10790	COG0471	metal ion transport
ND442_10805	COG3051	citrate lyase alpha subunit
ND442_10810	COG2301	Belongs to the HpcH HpaI aldolase family
ND442_10815	COG3052	prosthetic group binding
ND442_10820	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND442_10825	COG3290	protein histidine kinase activity
ND442_10830	COG4565	transcriptional regulatory protein
ND442_10845	COG2271	Major facilitator Superfamily
ND442_10850	COG1840	ABC-type Fe3 transport system, periplasmic component
ND442_10860	COG3842	ATPase activity
ND442_10880	COG1289	transmembrane transporter activity
ND442_10890	COG2925	Exonuclease
ND442_10895	COG0531	amino acid
ND442_10900	COG4771	TonB-dependent receptor
ND442_10910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND442_10920	COG0833	amino acid
ND442_10925	COG0583	DNA-binding transcription factor activity
ND442_10935	COG2855	membrane
ND442_10940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND442_10945	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND442_10945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND442_10945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND442_10950	COG1105	Belongs to the carbohydrate kinase PfkB family
ND442_10965	COG3005	denitrification pathway
ND442_10970	COG0243	molybdopterin cofactor binding
ND442_10990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND442_11000	COG0246	Mannitol dehydrogenase
ND442_11010	COG0523	cobalamin synthesis protein
ND442_11015	COG0671	phosphoesterase, PA-phosphatase related
ND442_11020	COG0791	NLP P60 protein
ND442_11025	COG2200	EAL domain
ND442_11030	COG4166	transmembrane transport
ND442_11035	COG4174	ABC transporter (Permease)
ND442_11040	COG4239	(ABC) transporter, permease
ND442_11045	COG4172	Belongs to the ABC transporter superfamily
ND442_11055	COG2814	Major facilitator Superfamily
ND442_11060	COG1187	pseudouridine synthase activity
ND442_11065	COG1061	Type III restriction enzyme res subunit
ND442_11080	COG3082	Protein of unknown function (DUF1414)
ND442_11085	COG3083	sulfuric ester hydrolase activity
ND442_11110	COG3778	Protein conserved in bacteria
ND442_11115	COG3299	homolog of phage Mu protein gp47
ND442_11170	COG3423	Transcriptional regulator
ND442_11235	COG4382	Mu-like prophage protein Gp16
ND442_11290	COG4383	Mu-like prophage protein gp29
ND442_11315	COG4397	Mu-like prophage major head subunit gpT
ND442_11340	COG4386	tail sheath protein
ND442_11390	COG5301	cellulose 1,4-beta-cellobiosidase activity
ND442_11405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ND442_11460	COG4626	Terminase
ND442_11460	COG1802	Transcriptional regulator
ND442_11485	COG1876	peptidase activity
ND442_11515	COG2815	serine threonine protein kinase
ND442_11515	COG0515	serine threonine protein kinase
ND442_11530	COG1403	HNH endonuclease
ND442_11545	COG4725	Belongs to the MT-A70-like family
ND442_11550	COG4626	Terminase
ND442_11550	COG1802	Transcriptional regulator
ND442_11585	COG5532	Uncharacterized conserved protein (DUF2303)
ND442_11590	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND442_11640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND442_11645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND442_11665	COG2223	nitrite transmembrane transporter activity
ND442_11670	COG0642	Histidine kinase
ND442_11670	COG2198	Histidine kinase
ND442_11680	COG2205	protein histidine kinase activity
ND442_11680	COG0784	Response regulator, receiver
ND442_11690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND442_11695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND442_11705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND442_11715	COG4574	serine-type endopeptidase inhibitor activity
ND442_11725	COG2246	polysaccharide biosynthetic process
ND442_11740	COG0814	amino acid
ND442_11765	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND442_11770	COG0596	Alpha beta hydrolase
ND442_11775	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND442_11780	COG1169	isochorismate synthase
ND442_11785	COG4575	ribosome binding
ND442_11800	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND442_11805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND442_11815	COG0839	Belongs to the complex I subunit 6 family
ND442_11820	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND442_11825	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND442_11830	COG1034	ATP synthesis coupled electron transport
ND442_11850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND442_11855	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND442_11860	COG0583	DNA-binding transcription factor activity
ND442_11865	COG0436	Aminotransferase
ND442_11870	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND442_11875	COG0490	domain, Protein
ND442_11875	COG0471	metal ion transport
ND442_11885	COG3013	Belongs to the UPF0304 family
ND442_11890	COG3092	negative regulation of chromosome organization
ND442_11900	COG0857	belongs to the CobB CobQ family
ND442_11900	COG0280	phosphate acetyltransferase
ND442_11905	COG1609	Transcriptional regulator
ND442_11920	COG3037	sugar-specific permease SgaT UlaA
ND442_11925	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND442_11930	COG0622	Phosphoesterase
ND442_11945	COG0625	glutathione transferase activity
ND442_11950	COG1090	epimerase
ND442_11960	COG4160	amino acid transport
ND442_11965	COG4215	(ABC) transporter
ND442_11980	COG0163	prenyltransferase activity
ND442_11985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND442_11990	COG1286	toxin biosynthetic process
ND442_11995	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND442_12000	COG0285	dihydrofolate synthase activity
ND442_12010	COG0586	Pfam SNARE associated Golgi protein
ND442_12020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND442_12045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND442_12050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND442_12080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND442_12095	COG3101	peptidyl-lysine hydroxylation
ND442_12100	COG0730	response to heat
ND442_12105	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND442_12115	COG2890	protein-(glutamine-N5) methyltransferase activity
ND442_12120	COG2840	Smr protein MutS2
ND442_12125	COG2062	phosphohistidine phosphatase, SixA
ND442_12130	COG1024	Enoyl-CoA hydratase
ND442_12130	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND442_12135	COG0183	Belongs to the thiolase family
ND442_12140	COG3691	Protein conserved in bacteria
ND442_12155	COG3088	subunit of a heme lyase
ND442_12155	COG4235	cytochrome complex assembly
ND442_12160	COG3088	subunit of a heme lyase
ND442_12160	COG4235	cytochrome complex assembly
ND442_12165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND442_12170	COG1138	Cytochrome C-type biogenesis protein
ND442_12175	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND442_12180	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND442_12185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND442_12190	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND442_12205	COG0582	viral genome integration into host DNA
ND442_12210	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ND442_12265	COG2824	Alkylphosphonate utilization operon protein PhnA
ND442_12270	COG2951	lytic endotransglycosylase activity
ND442_12275	COG1598	PFAM Uncharacterised protein family UPF0150
ND442_12285	COG3038	cytochrome b561
ND442_12290	COG0436	Aminotransferase
ND442_12300	COG3275	phosphorelay sensor kinase activity
ND442_12305	COG3279	Response regulator of the LytR AlgR family
ND442_12310	COG2223	nitrite transmembrane transporter activity
ND442_12315	COG0837	glucose binding
ND442_12335	COG1914	H( )-stimulated, divalent metal cation uptake system
ND442_12340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND442_12400	COG3530	Putative quorum-sensing-regulated virulence factor
ND442_12405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND442_12415	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND442_12425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND442_12440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND442_12450	COG4208	sulfate ABC transporter
ND442_12455	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND442_12460	COG4150	thiosulfate binding
ND442_12470	COG1737	Transcriptional regulator
ND442_12475	COG2731	YhcH YjgK YiaL family protein
ND442_12490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND442_12495	COG2837	iron assimilation
ND442_12505	COG3111	PFAM Bacterial OB fold (BOF) protein
ND442_12565	COG1671	Belongs to the UPF0178 family
ND442_12570	COG0280	phosphate acetyltransferase
ND442_12570	COG0281	malic enzyme
ND442_12575	COG0494	nUDIX hydrolase
ND442_12580	COG3005	denitrification pathway
ND442_12585	COG3043	anaerobic respiration
ND442_12590	COG0243	molybdopterin cofactor binding
ND442_12595	COG3062	negative regulation of establishment of protein localization
ND442_12600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND442_12600	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND442_12605	COG2197	response regulator
ND442_12615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND442_12625	COG1605	Chorismate mutase
ND442_12630	COG1393	Belongs to the ArsC family
ND442_12635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND442_12640	COG1876	peptidase activity
ND442_12650	COG0400	carboxylic ester hydrolase activity
ND442_12670	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND442_12675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND442_12680	COG2716	regulation of RNA biosynthetic process
ND442_12685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND442_12690	COG0628	permease
ND442_12695	COG4783	chaperone-mediated protein folding
ND442_12700	COG1393	Belongs to the ArsC family
ND442_12705	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND442_12710	COG2233	PERMEase
ND442_12715	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND442_12720	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND442_12725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND442_12730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND442_12740	COG0581	inorganic phosphate transmembrane transporter activity
ND442_12745	COG0573	inorganic phosphate transmembrane transporter activity
ND442_12750	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND442_12765	COG2239	Acts as a magnesium transporter
ND442_12770	COG0443	Heat shock 70 kDa protein
ND442_12780	COG3121	Chaperone
ND442_12800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND442_12810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND442_12815	COG0477	Major facilitator Superfamily
ND442_12820	COG2205	protein histidine kinase activity
ND442_12825	COG0745	RESPONSE REGULATOR receiver
ND442_12830	COG3422	double-strand break repair
ND442_12835	COG0826	peptidase U32
ND442_12840	COG1597	lipid kinase activity
ND442_12855	COG0351	phosphomethylpyrimidine kinase
ND442_12870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND442_12870	COG0519	Catalyzes the synthesis of GMP from XMP
ND442_12875	COG0517	IMP dehydrogenase activity
ND442_12875	COG0516	GMP reductase activity
ND442_12880	COG1570	exodeoxyribonuclease VII activity
ND442_12885	COG1645	bacterial-type flagellum-dependent swarming motility
ND442_12895	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND442_12900	COG2976	Protein conserved in bacteria
ND442_12905	COG0124	histidyl-tRNA synthetase
ND442_12925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND442_12940	COG4953	penicillin-binding protein 1C
ND442_12945	COG2373	Large extracellular alpha-helical protein
ND442_12960	COG2975	iron-sulfur cluster assembly
ND442_12965	COG0633	Ferredoxin
ND442_12970	COG0443	Heat shock 70 kDa protein
ND442_12985	COG0822	iron-sulfur transferase activity
ND442_12995	COG1959	2 iron, 2 sulfur cluster binding
ND442_13000	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND442_13010	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND442_13015	COG3683	transport system, periplasmic component
ND442_13020	COG3711	transcriptional antiterminator
ND442_13025	COG2814	Major facilitator Superfamily
ND442_13035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND442_13035	COG1017	nitric oxide dioxygenase activity
ND442_13040	COG2188	Transcriptional regulator
ND442_13050	COG3457	Alanine racemase
ND442_13055	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND442_13070	COG0347	Belongs to the P(II) protein family
ND442_13075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND442_13075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND442_13080	COG2204	response regulator
ND442_13085	COG3170	Tfp pilus assembly protein FimV
ND442_13090	COG2205	protein histidine kinase activity
ND442_13105	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND442_13115	COG0560	Phosphoserine phosphatase
ND442_13120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND442_13120	COG1263	PTS System
ND442_13130	COG1737	Transcriptional regulator
ND442_13135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND442_13145	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND442_13155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND442_13170	COG0481	GTPase activity
ND442_13175	COG3086	response to oxidative stress
ND442_13185	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND442_13195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND442_13205	COG0513	Belongs to the DEAD box helicase family
ND442_13220	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND442_13230	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND442_13235	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND442_13240	COG0497	DNA recombination
ND442_13245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND442_13255	COG2867	negative regulation of translational initiation
ND442_13260	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND442_13270	COG0582	viral genome integration into host DNA
ND442_13300	COG3596	GTP binding
ND442_13305	COG2378	regulation of single-species biofilm formation
ND442_13315	COG2378	regulation of single-species biofilm formation
ND442_13340	COG2003	Belongs to the UPF0758 family
ND442_13395	COG3121	Chaperone
ND442_13400	COG3188	usher protein
ND442_13425	COG0583	DNA-binding transcription factor activity
ND442_13500	COG1069	ribulokinase activity
ND442_13510	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND442_13515	COG1129	ABC transporter
ND442_13535	COG1620	l-lactate permease
ND442_13540	COG1304	FMN binding
ND442_13545	COG0579	oxidoreductase
ND442_13550	COG1278	Cold shock
ND442_13580	COG1780	Probably involved in ribonucleotide reductase function
ND442_13585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND442_13595	COG4175	Glycine betaine
ND442_13600	COG4176	ABC-type proline glycine betaine transport system permease component
ND442_13605	COG2113	Glycine betaine
ND442_13615	COG2814	Major facilitator Superfamily
ND442_13620	COG1846	Transcriptional regulator
ND442_13630	COG1566	PFAM secretion protein HlyD family protein
ND442_13635	COG2814	Major facilitator Superfamily
ND442_13640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND442_13645	COG3118	belongs to the thioredoxin family
ND442_13650	COG3148	PFAM DTW domain containing protein
ND442_13655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND442_13655	COG1042	CoA-binding domain protein
ND442_13655	COG0045	succinate-CoA ligase (ADP-forming) activity
ND442_13660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND442_13665	COG5544	Lipoprotein
ND442_13690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND442_13700	COG2011	ABC-type metal ion transport system permease component
ND442_13705	COG1464	Belongs to the NlpA lipoprotein family
ND442_13715	COG1720	tRNA m6t6A37 methyltransferase activity
ND442_13720	COG0442	prolyl-tRNA aminoacylation
ND442_13725	COG3015	lipoprotein NlpE involved in copper resistance
ND442_13735	COG4681	YaeQ
ND442_13745	COG4568	rho-dependent transcription termination
ND442_13760	COG0346	lactoylglutathione lyase activity
ND442_13775	COG0825	malonyl-CoA metabolic process
ND442_13780	COG0587	DNA-directed DNA polymerase activity
ND442_13785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND442_13805	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND442_13810	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND442_13820	COG0750	zinc metalloprotease
ND442_13825	COG0575	Belongs to the CDS family
ND442_13845	COG0528	UMP kinase activity
ND442_13850	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND442_13865	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND442_13870	COG2171	N-acyltransferase activity
ND442_13885	COG0564	pseudouridine synthase activity
ND442_13890	COG3098	single-species biofilm formation
ND442_13905	COG1611	Belongs to the LOG family
ND442_13915	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND442_13920	COG2363	Small membrane protein
ND442_13925	COG0583	DNA-binding transcription factor activity
ND442_13935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND442_13940	COG2166	iron-sulfur cluster assembly
ND442_13945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND442_13950	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND442_13970	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND442_13975	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND442_13975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND442_13980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND442_13985	COG1074	ATP-dependent DNA helicase activity
ND442_13990	COG1025	Belongs to the peptidase M16 family
ND442_13995	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND442_14000	COG4967	type IV pilus modification protein PilV
ND442_14025	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND442_14030	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND442_14040	COG3066	DNA modification
ND442_14045	COG0861	Integral membrane protein TerC family
ND442_14050	COG0667	Aldo Keto reductase
ND442_14055	COG0477	Major facilitator Superfamily
ND442_14060	COG0204	Acyl-transferase
ND442_14060	COG0318	PFAM AMP-dependent synthetase and ligase
ND442_14065	COG1609	Transcriptional regulator
ND442_14075	COG0583	DNA-binding transcription factor activity
ND442_14080	COG0583	DNA-binding transcription factor activity
ND442_14135	COG2165	general secretion pathway protein
ND442_14145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND442_14175	COG1127	ABC transporter
ND442_14180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND442_14190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND442_14200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND442_14205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND442_14210	COG4974	Belongs to the 'phage' integrase family
ND442_14215	COG0716	FMN binding
ND442_14225	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND442_14235	COG1272	protein, Hemolysin III
ND442_14255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND442_14260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND442_14265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND442_14270	COG0006	proline dipeptidase activity
ND442_14280	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND442_14290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND442_14295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND442_14300	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND442_14315	COG1279	arginine transmembrane transporter activity
ND442_14325	COG0191	fructose-bisphosphate aldolase activity
ND442_14330	COG0126	phosphoglycerate kinase activity
ND442_14335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND442_14340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND442_14350	COG1166	arginine decarboxylase activity
ND442_14355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND442_14370	COG0640	Transcriptional regulator
ND442_14375	COG3091	SprT-like family
ND442_14380	COG2356	endonuclease I
ND442_14385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND442_14390	COG0189	ligase activity
ND442_14395	COG1678	Uncharacterized ACR, COG1678
ND442_14400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND442_14405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND442_14415	COG2805	Type II/IV secretion system protein
ND442_14420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND442_14425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND442_14430	COG0762	integral membrane protein
ND442_14435	COG1872	DUF167
ND442_14440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND442_14445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND442_14460	COG3171	Protein conserved in bacteria
ND442_14470	COG1194	a g-specific adenine glycosylase
ND442_14475	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND442_14480	COG0741	lytic transglycosylase activity
ND442_14525	COG1105	Belongs to the carbohydrate kinase PfkB family
ND442_14530	COG1882	Formate acetyltransferase
ND442_14535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND442_14540	COG0814	amino acid
ND442_14555	COG1028	Short-chain dehydrogenase reductase Sdr
ND442_14560	COG1535	isochorismatase
ND442_14560	COG3433	isochorismatase activity
ND442_14565	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND442_14570	COG1169	isochorismate synthase
ND442_14575	COG4592	Periplasmic binding protein
ND442_14585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND442_14590	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND442_14595	COG1120	ATPase activity
ND442_14605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND442_14610	COG3251	PFAM MbtH domain protein
ND442_14620	COG4774	siderophore transport
ND442_14625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND442_14650	COG4964	Belongs to the GSP D family
ND442_14710	COG0848	biopolymer transport protein
ND442_14715	COG0811	peptide transport
ND442_14720	COG0626	cystathionine gamma-synthase activity
ND442_14725	COG0586	Pfam SNARE associated Golgi protein
ND442_14730	COG2207	Transcriptional regulator
ND442_14735	COG1979	alcohol dehydrogenase
ND442_14740	COG0656	L-ascorbic acid biosynthetic process
ND442_14750	COG2132	Multicopper oxidase
ND442_14765	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND442_14770	COG0583	DNA-binding transcription factor activity
ND442_14775	COG0187	DNA topoisomerase II activity
ND442_14780	COG3150	esterase
ND442_14785	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND442_14790	COG3151	Protein conserved in bacteria
ND442_14795	COG0494	nUDIX hydrolase
ND442_14800	COG1538	Outer membrane efflux protein
ND442_14805	COG5463	Belongs to the UPF0441 family
ND442_14810	COG0754	glutathionylspermidine amidase activity
ND442_14815	COG3384	dioxygenase
ND442_14820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND442_14835	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND442_14835	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND442_14845	COG3025	triphosphatase activity
ND442_14850	COG4991	sh3 domain protein
ND442_14855	COG0617	tRNA 3'-terminal CCA addition
ND442_14860	COG1968	undecaprenyl-diphosphatase activity
ND442_14865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND442_14870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND442_14875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND442_14880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND442_14885	COG0358	DNA primase activity
ND442_14915	COG1028	Short-chain dehydrogenase reductase Sdr
ND442_14945	COG0463	Glycosyl transferase, family 2
ND442_14980	COG3210	domain, Protein
ND442_14985	COG3210	domain, Protein
ND442_14995	COG2831	hemolysin activation secretion protein
ND442_15000	COG1902	pentaerythritol trinitrate reductase activity
ND442_15000	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND442_15015	COG1451	nucleotide metabolic process
ND442_15020	COG0673	inositol 2-dehydrogenase activity
ND442_15025	COG0861	Integral membrane protein TerC family
ND442_15030	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND442_15040	COG2721	sulfolactate sulfo-lyase activity
ND442_15055	COG2271	Major facilitator Superfamily
ND442_15070	COG0586	Pfam SNARE associated Golgi protein
ND442_15085	COG4575	ribosome binding
ND442_15090	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND442_15100	COG2259	Doxx family
ND442_15105	COG0583	DNA-binding transcription factor activity
ND442_15110	COG1741	Belongs to the pirin family
ND442_15125	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ND442_15140	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND442_15145	COG2823	Periplasmic or secreted lipoprotein
ND442_15150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND442_15155	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND442_15160	COG5002	protein histidine kinase activity
ND442_15160	COG0784	Response regulator, receiver
ND442_15160	COG2198	Histidine kinase
ND442_15165	COG1242	4 iron, 4 sulfur cluster binding
ND442_15170	COG0070	glutamate synthase
ND442_15170	COG0069	glutamate synthase activity
ND442_15170	COG0067	glutamate synthase
ND442_15175	COG0493	'glutamate synthase
ND442_15185	COG2969	positive regulation of protein catabolic process
ND442_15190	COG0625	glutathione transferase activity
ND442_15195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND442_15200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND442_15205	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND442_15210	COG3105	Protein conserved in bacteria
ND442_15215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND442_15225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND442_15230	COG5007	Belongs to the BolA IbaG family
ND442_15235	COG3113	response to antibiotic
ND442_15240	COG2854	intermembrane phospholipid transfer
ND442_15245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND442_15250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND442_15255	COG1127	ABC transporter
ND442_15260	COG0530	calcium, potassium:sodium antiporter activity
ND442_15265	COG0517	IMP dehydrogenase activity
ND442_15265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND442_15270	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND442_15275	COG3117	lipopolysaccharide transmembrane transporter activity
ND442_15280	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND442_15285	COG1137	ATPase activity
ND442_15290	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND442_15310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND442_15315	COG0540	Belongs to the ATCase OTCase family
ND442_15320	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND442_15330	COG0366	Alpha amylase catalytic
ND442_15335	COG1263	PTS System
ND442_15335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND442_15345	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND442_15355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND442_15360	COG3783	Cytochrome b(562)
ND442_15365	COG0312	modulator of DNA gyrase
ND442_15370	COG3028	Belongs to the UPF0307 family
ND442_15375	COG2732	(Barnase) inhibitor
ND442_15380	COG4290	ribonuclease
ND442_15390	COG1289	transmembrane transporter activity
ND442_15395	COG1566	PFAM secretion protein HlyD family protein
ND442_15405	COG0583	DNA-binding transcription factor activity
ND442_15410	COG0312	modulator of DNA gyrase
ND442_15415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND442_15420	COG3164	Protein of unknown function
ND442_15430	COG0424	maF-like protein
ND442_15435	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND442_15440	COG1792	Involved in formation and maintenance of cell shape
ND442_15445	COG1077	Cell shape determining protein MreB Mrl
ND442_15450	COG2200	EAL domain
ND442_15450	COG2199	diguanylate cyclase activity
ND442_15455	COG0604	alcohol dehydrogenase
ND442_15460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND442_15465	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND442_15475	COG0511	ligase activity, forming carbon-carbon bonds
ND442_15480	COG0439	Biotin carboxylase
ND442_15485	COG3924	membrane
ND442_15490	COG4145	pantothenate transmembrane transporter activity
ND442_15495	COG2264	protein methyltransferase activity
ND442_15500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND442_15505	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND442_15515	COG1560	Kdo2-lipid A biosynthetic process
ND442_15525	COG1346	cytolysis
ND442_15530	COG1380	Effector of murein hydrolase LrgA
ND442_15535	COG0583	DNA-binding transcription factor activity
ND442_15540	COG0025	NhaP-type Na H and K H
ND442_15545	COG2252	PERMEase
ND442_15560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND442_15565	COG2315	Protein conserved in bacteria
ND442_15570	COG1448	Aminotransferase
ND442_15595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND442_15600	COG0735	belongs to the Fur family
ND442_15605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND442_15610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND442_15615	COG2937	Belongs to the GPAT DAPAT family
ND442_15635	COG4580	involved in the transport of maltose and maltodextrins
ND442_15650	COG2182	Extracellular solute-binding protein
ND442_15655	COG1175	transmembrane transport
ND442_15660	COG3833	ABC-type maltose transport systems, permease component
ND442_15665	COG3223	Belongs to the PsiE family
ND442_15675	COG0527	aspartate kinase activity
ND442_15690	COG3328	transposase activity
ND442_15715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ND442_15795	COG0583	DNA-binding transcription factor activity
ND442_15835	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND442_15875	COG0138	bifunctional purine biosynthesis protein purh
ND442_15880	COG0151	Belongs to the GarS family
ND442_15900	COG1515	deoxyribonuclease V activity
ND442_15905	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND442_15910	COG2816	NAD+ diphosphatase activity
ND442_15915	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND442_15930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND442_15935	COG2104	thiamine diphosphate biosynthetic process
ND442_15940	COG2022	thiamine diphosphate biosynthetic process
ND442_15950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND442_15955	COG0085	RNA polymerase activity
ND442_15960	COG0222	ribosome binding
ND442_15965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND442_15975	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND442_15980	COG0250	Participates in transcription elongation, termination and antitermination
ND442_16025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND442_16050	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND442_16055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND442_16060	COG1739	Uncharacterized protein family UPF0029
ND442_16070	COG1024	Enoyl-CoA hydratase
ND442_16070	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND442_16080	COG0543	2 iron, 2 sulfur cluster binding
ND442_16095	COG0250	Participates in transcription elongation, termination and antitermination
ND442_16110	COG0805	protein transport
ND442_16115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND442_16120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND442_16125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND442_16130	COG3165	ubiquinone biosynthetic process from chorismate
ND442_16135	COG2226	methyltransferase
ND442_16140	COG1322	Protein conserved in bacteria
ND442_16145	COG0586	Pfam SNARE associated Golgi protein
ND442_16150	COG1966	Carbon starvation protein
ND442_16165	COG0412	Dienelactone hydrolase
ND442_16170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND442_16175	COG0583	DNA-binding transcription factor activity
ND442_16180	COG0697	spore germination
ND442_16190	COG0584	glycerophosphoryl diester phosphodiesterase
ND442_16200	COG0395	ABC-type sugar transport system, permease component
ND442_16205	COG1175	transmembrane transport
ND442_16210	COG1653	transport
ND442_16245	COG0410	ABC transporter
ND442_16255	COG4177	L-phenylalanine transmembrane transporter activity
ND442_16275	COG1929	Belongs to the glycerate kinase type-1 family
ND442_16280	COG2610	gluconate transmembrane transporter activity
ND442_16285	COG3835	regulator
ND442_16295	COG2177	Part of the ABC transporter FtsEX involved in
ND442_16300	COG2884	Cell division ATP-binding protein ftsE
ND442_16305	COG0552	protein localization to endoplasmic reticulum
ND442_16305	COG0552	protein localization to endoplasmic reticulum
ND442_16310	COG0742	ribosomal rna small subunit methyltransferase
ND442_16315	COG3776	membrane
ND442_16330	COG3714	YhhN family
ND442_16345	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND442_16355	COG0247	lactate metabolic process
ND442_16365	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND442_16375	COG2271	Major facilitator Superfamily
ND442_16380	COG0584	glycerophosphoryl diester phosphodiesterase
ND442_16385	COG0561	phosphatase activity
ND442_16390	COG2267	carboxylic ester hydrolase activity
ND442_16395	COG1280	lysine exporter protein (LysE YggA)
ND442_16400	COG0514	ATP-dependent DNA helicase (RecQ)
ND442_16405	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND442_16410	COG2050	protein possibly involved in aromatic compounds catabolism
ND442_16430	COG5564	TIM-barrel signal transduction protein
ND442_16435	COG5441	Belongs to the UPF0261 family
ND442_16445	COG0210	DNA helicase
ND442_16450	COG1011	Hydrolase
ND442_16455	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND442_16460	COG3159	Protein conserved in bacteria
ND442_16465	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND442_16470	COG5567	small periplasmic lipoprotein
ND442_16480	COG3072	Adenylate cyclase
ND442_16485	COG0181	hydroxymethylbilane synthase activity
ND442_16490	COG1587	Uroporphyrinogen-III synthase
ND442_16495	COG2959	enzyme of heme biosynthesis
ND442_16500	COG3071	HemY protein
ND442_16550	COG2244	polysaccharide biosynthetic process
ND442_16555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND442_16560	COG0456	acetyltransferase
ND442_16565	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND442_16570	COG1088	dTDP-glucose 4,6-dehydratase activity
ND442_16575	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND442_16580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND442_16585	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND442_16590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND442_16595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND442_16600	COG3118	belongs to the thioredoxin family
ND442_16610	COG0248	Ppx GppA phosphatase
ND442_16620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND442_16635	COG3397	chitin binding
ND442_16645	COG0129	dihydroxy-acid dehydratase activity
ND442_16655	COG3978	acetolactate synthase activity
ND442_16675	COG3085	chromosome segregation
ND442_16680	COG0583	DNA-binding transcription factor activity
ND442_16755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND442_16765	COG0678	peroxiredoxin activity
ND442_16765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND442_16770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND442_16805	COG1629	transport
ND442_16810	COG0165	Argininosuccinate lyase
ND442_16815	COG0137	argininosuccinate synthase activity
ND442_16820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND442_16865	COG0527	aspartate kinase activity
ND442_16865	COG0460	homoserine dehydrogenase
ND442_16870	COG0626	cystathionine gamma-synthase activity
ND442_16875	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND442_16885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND442_16890	COG1609	Transcriptional regulator
ND442_16895	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND442_16900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND442_16905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND442_16910	COG1575	Belongs to the MenA family. Type 1 subfamily
ND442_16915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND442_16920	COG3074	FtsZ-dependent cytokinesis
ND442_16925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND442_16930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND442_16935	COG1494	fructose-1,6-bisphosphatase
ND442_16940	COG2814	Major facilitator Superfamily
ND442_16950	COG3152	Membrane
ND442_16965	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND442_16975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND442_16980	COG3678	ATP-independent chaperone mediated protein folding
ND442_16985	COG0745	RESPONSE REGULATOR receiver
ND442_16990	COG2205	protein histidine kinase activity
ND442_16995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND442_17000	COG1045	serine acetyltransferase
ND442_17005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND442_17010	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND442_17015	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND442_17020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND442_17025	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND442_17030	COG4942	peptidase
ND442_17035	COG2861	carbohydrate metabolic process
ND442_17050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND442_17055	COG0859	PFAM glycosyl transferase family 9
ND442_17060	COG0859	PFAM glycosyl transferase family 9
ND442_17065	COG1519	Transferase
ND442_17085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND442_17090	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND442_17095	COG2003	Belongs to the UPF0758 family
ND442_17100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND442_17105	COG0756	dUTP diphosphatase activity
ND442_17110	COG1309	transcriptional regulator
ND442_17115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND442_17120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND442_17125	COG1561	YicC-like family, N-terminal region
ND442_17140	COG5001	Diguanylate cyclase
ND442_17145	COG1024	Enoyl-CoA hydratase
ND442_17150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND442_17160	COG2860	membrane
ND442_17165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND442_17175	COG1758	RNA polymerase activity
ND442_17180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND442_17185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND442_17190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND442_17195	COG0786	glutamate:sodium symporter activity
ND442_17200	COG2233	PERMEase
ND442_17205	COG2982	Protein involved in outer membrane biogenesis
ND442_17210	COG0456	acetyltransferase
ND442_17225	COG1011	Hydrolase
ND442_17240	COG3852	Histidine kinase
ND442_17250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND442_17260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND442_17265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND442_17265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND442_17270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND442_17275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND442_17280	COG3084	Protein conserved in bacteria
ND442_17290	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND442_17315	COG2186	Transcriptional regulator
ND442_17320	COG1609	Transcriptional regulator
ND442_17325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND442_17335	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND442_17340	COG1129	ABC transporter
ND442_17345	COG1869	D-ribose catabolic process
ND442_17350	COG3158	transport of potassium into the cell
ND442_17355	COG0714	Associated with various cellular activities
ND442_17360	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND442_17370	COG2502	aspartate--ammonia ligase
ND442_17375	COG1522	sequence-specific DNA binding
ND442_17380	COG0716	FMN binding
ND442_17385	COG0445	tRNA wobble uridine modification
ND442_17390	COG0357	Ribosomal RNA small subunit methyltransferase G
ND442_17395	COG3312	ion transport
ND442_17400	COG0356	it plays a direct role in the translocation of protons across the membrane
ND442_17410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND442_17420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND442_17425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND442_17435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND442_17450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND442_17455	COG0573	inorganic phosphate transmembrane transporter activity
ND442_17460	COG0581	inorganic phosphate transmembrane transporter activity
ND442_17470	COG0704	Plays a role in the regulation of phosphate uptake
ND442_17475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND442_17480	COG0765	amino acid transport
ND442_17485	COG0765	amino acid transport
ND442_17490	COG2252	PERMEase
ND442_17495	COG0840	transmembrane signaling receptor activity
ND442_17505	COG3121	Chaperone
ND442_17520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND442_17525	COG0706	membrane insertase activity
ND442_17535	COG0594	ribonuclease P activity
ND442_17540	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ND442_17575	COG1454	alcohol dehydrogenase
ND442_17680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND442_17695	COG0741	lytic transglycosylase activity
ND442_17855	COG2944	sequence-specific DNA binding
ND442_17925	COG1192	Involved in chromosome partitioning