locus-tag	class	description
ND448_00010	COG0592	DNA-directed DNA polymerase activity
ND448_00020	COG0187	DNA topoisomerase II activity
ND448_00025	COG0561	phosphatase activity
ND448_00030	COG0823	Involved in the tonB-independent uptake of proteins
ND448_00035	COG5645	(Lipo)protein
ND448_00050	COG0569	domain protein
ND448_00050	COG2985	domain, Protein
ND448_00055	COG3977	Valine--pyruvate aminotransferase
ND448_00060	COG2885	chlorophyll binding
ND448_00080	COG2818	Glycosylase
ND448_00130	COG2213	PTS system mannitol-specific
ND448_00130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND448_00140	COG3722	fumarate hydratase activity
ND448_00150	COG2258	MOSC domain
ND448_00155	COG0840	transmembrane signaling receptor activity
ND448_00160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND448_00175	COG0437	4 iron, 4 sulfur cluster binding
ND448_00180	COG2864	formate dehydrogenase
ND448_00190	COG1921	L-seryl-tRNASec selenium transferase activity
ND448_00195	COG3276	selenocysteine insertion sequence binding
ND448_00200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND448_00210	COG3274	enterobacterial common antigen metabolic process
ND448_00220	COG0582	viral genome integration into host DNA
ND448_00255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND448_00260	COG2986	histidine ammonia-lyase
ND448_00280	COG2194	sulfuric ester hydrolase activity
ND448_00285	COG2197	response regulator
ND448_00290	COG3851	Histidine kinase
ND448_00295	COG2271	Major facilitator Superfamily
ND448_00305	COG0747	negative chemotaxis
ND448_00310	COG0601	transmembrane transport
ND448_00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND448_00320	COG0444	Belongs to the ABC transporter superfamily
ND448_00325	COG4608	Belongs to the ABC transporter superfamily
ND448_00330	COG2194	sulfuric ester hydrolase activity
ND448_00355	COG1215	transferase activity, transferring glycosyl groups
ND448_00360	COG1215	transferase activity, transferring glycosyl groups
ND448_00365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND448_00370	COG0457	Tetratricopeptide repeat
ND448_00370	COG3118	belongs to the thioredoxin family
ND448_00375	COG2199	diguanylate cyclase activity
ND448_00375	COG2200	EAL domain
ND448_00380	COG1301	dicarboxylic acid transport
ND448_00385	COG0612	Peptidase, M16
ND448_00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND448_00395	COG1942	4-Oxalocrotonate Tautomerase
ND448_00400	COG2200	EAL domain
ND448_00405	COG2134	cdp-diacylglycerol pyrophosphatase
ND448_00410	COG1295	ribonuclease BN
ND448_00420	COG1301	dicarboxylic acid transport
ND448_00425	COG0626	cystathionine gamma-synthase activity
ND448_00435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND448_00440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND448_00445	COG0339	signal peptide processing
ND448_00450	COG0742	ribosomal rna small subunit methyltransferase
ND448_00460	COG0589	response to stress
ND448_00470	COG0306	phosphate transporter
ND448_00475	COG2081	HI0933 family
ND448_00485	COG1247	-acetyltransferase
ND448_00495	COG1741	Belongs to the pirin family
ND448_00500	COG1609	Transcriptional regulator
ND448_00505	COG2610	gluconate transmembrane transporter activity
ND448_00510	COG3265	gluconokinase activity
ND448_00515	COG2095	MarC family integral membrane protein
ND448_00520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND448_00525	COG3275	phosphorelay sensor kinase activity
ND448_00530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND448_00535	COG1523	belongs to the glycosyl hydrolase 13 family
ND448_00540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND448_00545	COG0297	glycogen (starch) synthase activity
ND448_00550	COG0058	SHG alpha-glucan phosphorylase activity
ND448_00555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND448_00560	COG1349	DNA-binding transcription factor activity
ND448_00565	COG0705	Rhomboid family
ND448_00575	COG2909	trisaccharide binding
ND448_00580	COG0058	SHG alpha-glucan phosphorylase activity
ND448_00585	COG1640	4-alpha-glucanotransferase
ND448_00595	COG1040	competence protein
ND448_00600	COG0596	Alpha beta hydrolase
ND448_00620	COG1918	ferrous iron import across plasma membrane
ND448_00625	COG2183	response to ionizing radiation
ND448_00650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND448_00665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND448_00675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND448_00680	COG1011	Hydrolase
ND448_00690	COG0494	nUDIX hydrolase
ND448_00695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND448_00720	COG4796	Type ii and iii secretion system protein
ND448_00725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND448_00745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND448_00755	COG0180	Tryptophanyl-tRNA synthetase
ND448_00775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND448_00780	COG0402	S-adenosylhomocysteine deaminase activity
ND448_00785	COG0738	Major facilitator superfamily
ND448_00800	COG1609	Transcriptional regulator
ND448_00805	COG1486	melibiose metabolic process
ND448_00810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND448_00825	COG1289	transmembrane transporter activity
ND448_00830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND448_00835	COG1765	OsmC-like protein
ND448_00860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND448_00865	COG3954	Phosphoribulokinase
ND448_00875	COG0429	hydrolase of the alpha beta-hydrolase fold
ND448_00885	COG0859	PFAM glycosyl transferase family 9
ND448_00890	COG1216	Glycosyl transferase, family 2
ND448_00895	COG0488	(ABC) transporter
ND448_00900	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND448_00910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND448_00915	COG1047	Peptidyl-prolyl cis-trans
ND448_00925	COG0545	Peptidyl-prolyl cis-trans isomerase
ND448_00930	COG2964	Protein conserved in bacteria
ND448_00940	COG2923	Belongs to the DsrF TusC family
ND448_00945	COG2168	tRNA wobble position uridine thiolation
ND448_00950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND448_00955	COG0049	tRNA binding
ND448_00965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND448_00980	COG0051	transcription antitermination factor activity, RNA binding
ND448_00985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND448_00995	COG0089	rRNA binding
ND448_01000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND448_01005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND448_01010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND448_01020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND448_01025	COG0255	Belongs to the universal ribosomal protein uL29 family
ND448_01030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND448_01035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND448_01045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND448_01070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND448_01075	COG1841	ribosomal large subunit assembly
ND448_01080	COG0200	Binds to the 23S rRNA
ND448_01085	COG0201	protein transport
ND448_01090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND448_01095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND448_01105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND448_01115	COG0203	ribosomal protein L17
ND448_01120	COG0789	Transcriptional regulator
ND448_01125	COG3036	rescue of stalled ribosome
ND448_01130	COG1970	mechanosensitive ion channel activity
ND448_01140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND448_01140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND448_01145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND448_01150	COG0242	peptide deformylase activity
ND448_01155	COG0758	DNA mediated transformation
ND448_01160	COG2922	Belongs to the Smg family
ND448_01165	COG0551	DNA topoisomerase type I activity
ND448_01170	COG0009	L-threonylcarbamoyladenylate synthase
ND448_01180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND448_01210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND448_01215	COG3162	membrane
ND448_01220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND448_01225	COG1301	dicarboxylic acid transport
ND448_01235	COG2391	methyltransferase activity
ND448_01240	COG0425	Belongs to the sulfur carrier protein TusA family
ND448_01245	COG1086	Polysaccharide biosynthesis protein
ND448_01250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND448_01255	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND448_01260	COG2089	acid synthase
ND448_01280	COG2755	lipolytic protein G-D-S-L family
ND448_01280	COG1083	cytidylyl-transferase
ND448_01285	COG1028	Short-chain dehydrogenase reductase Sdr
ND448_01305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND448_01305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND448_01310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ND448_01330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND448_01350	COG1309	transcriptional regulator
ND448_01355	COG4232	protein-disulfide reductase activity
ND448_01365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND448_01395	COG1509	lysine 2,3-aminomutase activity
ND448_01405	COG3397	chitin binding
ND448_01425	COG3188	usher protein
ND448_01445	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND448_01450	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND448_01455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND448_01460	COG1053	succinate dehydrogenase
ND448_01465	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND448_01470	COG3264	Mechanosensitive ion channel
ND448_01470	COG1511	domain protein
ND448_01475	COG0688	phosphatidylethanolamine metabolic process
ND448_01480	COG1162	GTPase activity
ND448_01485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND448_01505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND448_01510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND448_01510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND448_01515	COG0802	atpase or kinase
ND448_01520	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND448_01530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND448_01540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND448_01545	COG0330	HflC and HflK could
ND448_01550	COG0330	HflC and HflK could
ND448_01555	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND448_01560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND448_01565	COG1959	2 iron, 2 sulfur cluster binding
ND448_01570	COG0557	exoribonuclease II activity
ND448_01575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND448_01595	COG3121	Chaperone
ND448_01600	COG3188	usher protein
ND448_01620	COG1073	alpha beta
ND448_01630	COG0360	Binds together with S18 to 16S ribosomal RNA
ND448_01635	COG2965	DNA replication, synthesis of RNA primer
ND448_01640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND448_01645	COG0359	binds to the 23S rRNA
ND448_01650	COG3061	Opacity-associated protein A
ND448_01655	COG0545	Peptidyl-prolyl cis-trans isomerase
ND448_01665	COG0737	Belongs to the 5'-nucleotidase family
ND448_01670	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND448_01675	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND448_01685	COG1253	flavin adenine dinucleotide binding
ND448_01690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND448_01695	COG0729	surface antigen
ND448_01700	COG2911	Protein conserved in bacteria
ND448_01705	COG2105	PFAM AIG2 family protein
ND448_01710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND448_01720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND448_01735	COG3423	Transcriptional regulator
ND448_01750	COG0142	geranyltranstransferase activity
ND448_01765	COG0697	spore germination
ND448_01770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND448_01775	COG0642	Histidine kinase
ND448_01780	COG0745	RESPONSE REGULATOR receiver
ND448_01785	COG2027	D-alanyl-D-alanine carboxypeptidase
ND448_01795	COG1534	Rna-binding protein
ND448_01800	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND448_01810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND448_01815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND448_01820	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND448_01840	COG0195	Participates in both transcription termination and antitermination
ND448_01850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND448_01865	COG1185	polyribonucleotide nucleotidyltransferase activity
ND448_01875	COG0513	Belongs to the DEAD box helicase family
ND448_01880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND448_01895	COG0826	peptidase U32
ND448_01900	COG0826	peptidase U32
ND448_01905	COG3154	lipid carrier protein
ND448_01910	COG3153	acetyltransferase
ND448_01915	COG2827	Endonuclease containing a URI domain
ND448_01920	COG0531	amino acid
ND448_01925	COG1982	Orn Lys Arg decarboxylase major
ND448_01935	COG3787	Belongs to the UPF0306 family
ND448_01940	COG0702	epimerase
ND448_01945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND448_01950	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND448_01955	COG3454	Phosphonate metabolism
ND448_01960	COG4778	phosphonate C-P lyase system protein PhnL
ND448_01965	COG4107	phosphonate C-P lyase system protein PhnK
ND448_01970	COG3627	carbon phosphorus lyase activity
ND448_01975	COG3626	phosphonate metabolism
ND448_01980	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND448_01985	COG3624	Phosphonate C-P lyase system protein PhnG
ND448_02005	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND448_02020	COG2927	DNA polymerase III (CHI subunit)
ND448_02025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND448_02030	COG0795	lipopolysaccharide-transporting ATPase activity
ND448_02035	COG0795	lipopolysaccharide-transporting ATPase activity
ND448_02075	COG3077	Addiction module antitoxin, RelB DinJ family
ND448_02180	COG5492	domain, Protein
ND448_02200	COG3119	arylsulfatase activity
ND448_02205	COG1349	DNA-binding transcription factor activity
ND448_02215	COG2222	sugar isomerase
ND448_02220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND448_02225	COG3715	PTS system
ND448_02230	COG3716	PTS system mannose fructose sorbose family IID component
ND448_02240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND448_02250	COG1028	Short-chain dehydrogenase reductase Sdr
ND448_02260	COG0641	radical SAM
ND448_02265	COG3119	arylsulfatase activity
ND448_02290	COG0859	PFAM glycosyl transferase family 9
ND448_02305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND448_02310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND448_02320	COG2376	Dihydroxyacetone kinase
ND448_02325	COG1461	Dihydroxyacetone kinase
ND448_02330	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND448_02330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND448_02330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND448_02370	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND448_02385	COG2823	Periplasmic or secreted lipoprotein
ND448_02395	COG4667	esterase of the alpha-beta hydrolase superfamily
ND448_02400	COG0084	hydrolase, TatD family'
ND448_02405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND448_02420	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND448_02430	COG3726	membrane protein affecting hemolysin expression
ND448_02435	COG0560	Phosphoserine phosphatase
ND448_02450	COG0488	(ABC) transporter
ND448_02475	COG0741	lytic transglycosylase activity
ND448_02480	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND448_02485	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND448_02490	COG0406	alpha-ribazole phosphatase activity
ND448_02495	COG2207	Transcriptional regulator
ND448_02495	COG3708	Transcriptional regulator
ND448_02500	COG3045	CreA protein
ND448_02505	COG0745	RESPONSE REGULATOR receiver
ND448_02540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND448_02545	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND448_02550	COG0477	Major facilitator Superfamily
ND448_02560	COG1584	GPR1 FUN34 yaaH family protein
ND448_02565	COG0443	Heat shock 70 kDa protein
ND448_02575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND448_02580	COG0583	DNA-binding transcription factor activity
ND448_02590	COG0196	riboflavin kinase activity
ND448_02600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND448_02605	COG1047	Peptidyl-prolyl cis-trans
ND448_02610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND448_02625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND448_02635	COG2966	Psort location CytoplasmicMembrane, score
ND448_02660	COG2967	ApaG domain
ND448_02665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND448_02670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND448_02680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND448_02690	COG0564	pseudouridine synthase activity
ND448_02695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND448_02700	COG0417	DNA replication proofreading
ND448_02705	COG0586	Pfam SNARE associated Golgi protein
ND448_02715	COG1178	ABC-type Fe3 transport system permease component
ND448_02720	COG4143	(ABC) transporter
ND448_02735	COG2814	Major facilitator Superfamily
ND448_02745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND448_02750	COG0473	3-isopropylmalate dehydrogenase activity
ND448_02765	COG1022	Amp-dependent synthetase and ligase
ND448_02770	COG0028	Belongs to the TPP enzyme family
ND448_02795	COG0275	rRNA processing
ND448_02800	COG3116	cell division
ND448_02805	COG0768	penicillin binding
ND448_02810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND448_02815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND448_02830	COG0772	Belongs to the SEDS family
ND448_02835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND448_02840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND448_02850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND448_02855	COG0849	cell division
ND448_02860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND448_02885	COG0494	nUDIX hydrolase
ND448_02905	COG0516	GMP reductase activity
ND448_02910	COG1459	type II secretion system
ND448_02915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND448_02920	COG4969	Belongs to the N-Me-Phe pilin family
ND448_02935	COG3725	Membrane protein required for beta-lactamase induction
ND448_02940	COG1113	amino acid transport
ND448_02945	COG2186	Transcriptional regulator
ND448_02950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND448_02955	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND448_02960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND448_02970	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND448_02975	COG3112	Uncharacterised protein family (UPF0231)
ND448_02990	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND448_03000	COG2132	Multicopper oxidase
ND448_03010	COG0288	reversible hydration of carbon dioxide
ND448_03015	COG1131	(ABC) transporter
ND448_03020	COG0842	Transport permease protein
ND448_03025	COG0726	polysaccharide deacetylase
ND448_03030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND448_03035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND448_03040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND448_03045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND448_03050	COG0617	tRNA 3'-terminal CCA addition
ND448_03065	COG1489	DNA binding
ND448_03070	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND448_03075	COG1643	Atp-dependent helicase
ND448_03080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND448_03085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND448_03095	COG0316	Belongs to the HesB IscA family
ND448_03100	COG2860	membrane
ND448_03110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND448_03115	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND448_03120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND448_03130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND448_03135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND448_03140	COG3956	TIGRFAM MazG family protein
ND448_03145	COG0504	CTP synthase activity
ND448_03155	COG0602	queuosine metabolic process
ND448_03160	COG0720	synthase
ND448_03165	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND448_03175	COG0175	sulfate reduction
ND448_03190	COG2234	aminopeptidase activity
ND448_03195	COG1648	precorrin-2 dehydrogenase activity
ND448_03195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND448_03200	COG0175	sulfate reduction
ND448_03205	COG2895	sulfate adenylyltransferase (ATP) activity
ND448_03210	COG0529	Catalyzes the synthesis of activated sulfate
ND448_03220	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND448_03230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND448_03235	COG0585	pseudouridine synthase activity
ND448_03240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND448_03250	COG1388	LysM domain
ND448_03250	COG4942	peptidase
ND448_03255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND448_03260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND448_03330	COG2205	protein histidine kinase activity
ND448_03330	COG0784	Response regulator, receiver
ND448_03350	COG0741	lytic transglycosylase activity
ND448_03480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND448_03500	COG3397	chitin binding
ND448_03510	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ND448_03555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND448_03565	COG3031	protein transport across the cell outer membrane
ND448_03590	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND448_03590	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND448_03605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND448_03610	COG2137	regulation of response to DNA damage stimulus
ND448_03615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND448_03620	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND448_03650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND448_03655	COG1238	metal cluster binding
ND448_03660	COG2918	glutathione biosynthetic process
ND448_03665	COG1854	S-ribosylhomocysteine lyase activity
ND448_03670	COG4536	flavin adenine dinucleotide binding
ND448_03675	COG4137	Cytochrome C assembly protein
ND448_03680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND448_03690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND448_03695	COG0336	Belongs to the RNA methyltransferase TrmD family
ND448_03700	COG0335	large ribosomal subunit rRNA binding
ND448_03705	COG3137	Salt-induced outer membrane protein
ND448_03710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND448_03715	COG3279	Response regulator of the LytR AlgR family
ND448_03720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND448_03725	COG1605	Chorismate mutase
ND448_03725	COG0287	Prephenate dehydrogenase
ND448_03730	COG1605	Chorismate mutase
ND448_03730	COG0077	Prephenate dehydratase
ND448_03740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND448_03745	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND448_03750	COG0564	pseudouridine synthase activity
ND448_03755	COG1496	oxidoreductase activity
ND448_03760	COG0542	response to heat
ND448_03795	COG3021	interspecies interaction between organisms
ND448_03800	COG0741	lytic transglycosylase activity
ND448_03800	COG1388	LysM domain
ND448_03810	COG2226	methyltransferase
ND448_03820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND448_03830	COG1960	acyl-CoA dehydrogenase activity
ND448_03835	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND448_03840	COG0121	glutamine amidotransferase
ND448_03845	COG3034	peptidoglycan biosynthetic process
ND448_03855	COG1805	sodium ion transport
ND448_03860	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND448_03865	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND448_03870	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND448_03880	COG1477	protein flavinylation
ND448_03885	COG2991	Protein conserved in bacteria
ND448_03895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND448_03900	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND448_03905	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND448_03910	COG1073	alpha beta
ND448_03925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND448_03960	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND448_03980	COG4126	flavin adenine dinucleotide binding
ND448_03990	COG2974	May be involved in recombination
ND448_03995	COG1940	carbohydrate kinase activity
ND448_04000	COG0419	ATPase involved in DNA repair
ND448_04005	COG0420	3'-5' exonuclease activity
ND448_04010	COG0745	RESPONSE REGULATOR receiver
ND448_04015	COG5002	protein histidine kinase activity
ND448_04030	COG1113	amino acid transport
ND448_04035	COG0366	Alpha amylase catalytic
ND448_04040	COG0300	oxidoreductase activity
ND448_04045	COG0450	alkyl hydroperoxide reductase
ND448_04050	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND448_04065	COG1862	Preprotein translocase
ND448_04070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND448_04075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND448_04080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND448_04085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND448_04085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND448_04090	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND448_04100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND448_04105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND448_04110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND448_04115	COG0142	geranyltranstransferase activity
ND448_04150	COG0693	protein deglycase activity
ND448_04155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND448_04160	COG1666	GTP binding
ND448_04165	COG2814	Major facilitator Superfamily
ND448_04175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND448_04180	COG1845	cytochrome c oxidase, subunit III
ND448_04185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND448_04190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND448_04200	COG2223	nitrite transmembrane transporter activity
ND448_04205	COG3056	Lipoprotein
ND448_04210	COG0271	Belongs to the BolA IbaG family
ND448_04220	COG0740	serine-type endopeptidase activity
ND448_04225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND448_04230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND448_04235	COG0776	regulation of translation
ND448_04240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND448_04245	COG1555	photosystem II stabilization
ND448_04250	COG0824	Thioesterase
ND448_04255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND448_04260	COG4533	DNA binding
ND448_04275	COG1522	sequence-specific DNA binding
ND448_04280	COG1132	(ABC) transporter
ND448_04285	COG1132	(ABC) transporter
ND448_04290	COG0347	Belongs to the P(II) protein family
ND448_04295	COG0004	ammonium transporteR
ND448_04300	COG1946	Acyl-CoA thioesterase
ND448_04305	COG3695	enzyme binding
ND448_04330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND448_04335	COG0254	rRNA binding
ND448_04340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND448_04345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND448_04350	COG1309	transcriptional regulator
ND448_04355	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND448_04360	COG1196	nuclear chromosome segregation
ND448_04360	COG3264	Mechanosensitive ion channel
ND448_04375	COG2832	Protein of unknown function (DUF454)
ND448_04380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND448_04420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND448_04425	COG0326	Molecular chaperone. Has ATPase activity
ND448_04440	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND448_04445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND448_04450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND448_04450	COG4651	solute:proton antiporter activity
ND448_04455	COG0737	Belongs to the 5'-nucleotidase family
ND448_04460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND448_04465	COG3735	TraB family
ND448_04470	COG2217	Heavy metal translocating P-type atpase
ND448_04475	COG0789	Transcriptional regulator
ND448_04480	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND448_04485	COG0330	HflC and HflK could
ND448_04490	COG3118	belongs to the thioredoxin family
ND448_04495	COG0300	oxidoreductase activity
ND448_04500	COG2755	lipolytic protein G-D-S-L family
ND448_04505	COG4181	ATPase activity
ND448_04510	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND448_04515	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND448_04520	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND448_04525	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND448_04530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND448_04555	COG3188	usher protein
ND448_04560	COG3121	Chaperone
ND448_04590	COG2501	S4 domain
ND448_04595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND448_04610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND448_04615	COG1393	Belongs to the ArsC family
ND448_04625	COG1022	Amp-dependent synthetase and ligase
ND448_04650	COG3038	cytochrome b561
ND448_04680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND448_04690	COG1215	transferase activity, transferring glycosyl groups
ND448_04710	COG3250	beta-galactosidase activity
ND448_04725	COG1309	transcriptional regulator
ND448_04755	COG2197	response regulator
ND448_04760	COG1278	Cold shock
ND448_04780	COG3706	GGDEF domain
ND448_04790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND448_04800	COG2921	Belongs to the UPF0250 family
ND448_04805	COG1686	Belongs to the peptidase S11 family
ND448_04810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND448_04815	COG0772	Belongs to the SEDS family
ND448_04820	COG0768	penicillin binding
ND448_04825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND448_04830	COG0799	negative regulation of ribosome biogenesis
ND448_04835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND448_04840	COG1466	dna polymerase III delta subunit
ND448_04845	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND448_04855	COG2888	peptidyl-tyrosine sulfation
ND448_04860	COG1126	abc transporter atp-binding protein
ND448_04865	COG0765	amino acid transport
ND448_04870	COG0765	amino acid transport
ND448_04880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND448_04885	COG4535	Mg2 and Co2 transporter CorC
ND448_04890	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND448_04895	COG1702	phosphate starvation-inducible protein PhoH
ND448_04900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND448_04905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND448_04940	COG0367	asparagine synthase
ND448_04945	COG0647	UMP catabolic process
ND448_04950	COG1940	carbohydrate kinase activity
ND448_04950	COG1846	Transcriptional regulator
ND448_04955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND448_04965	COG1263	PTS System
ND448_04965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND448_04965	COG2190	(PTS) system
ND448_04990	COG0735	belongs to the Fur family
ND448_05000	COG0840	transmembrane signaling receptor activity
ND448_05010	COG0596	Alpha beta hydrolase
ND448_05015	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND448_05020	COG0033	Phosphoglucomutase
ND448_05030	COG0745	RESPONSE REGULATOR receiver
ND448_05035	COG2205	protein histidine kinase activity
ND448_05040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND448_05045	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND448_05065	COG3272	Protein of unknown function (DUF1722)
ND448_05070	COG0415	Belongs to the DNA photolyase family
ND448_05075	COG5212	phosphodiesterase
ND448_05080	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND448_05085	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND448_05090	COG1984	allophanate hydrolase subunit 2
ND448_05095	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND448_05130	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND448_05135	COG1053	succinate dehydrogenase
ND448_05140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND448_05145	COG0567	Dehydrogenase, E1 component
ND448_05150	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND448_05155	COG0045	succinate-CoA ligase (ADP-forming) activity
ND448_05160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND448_05165	COG0737	Belongs to the 5'-nucleotidase family
ND448_05170	COG1271	oxidase subunit
ND448_05175	COG1294	oxidase, subunit
ND448_05180	COG4890	Cyd operon protein YbgT
ND448_05185	COG3790	cyd operon protein YbgE
ND448_05190	COG0824	Thioesterase
ND448_05195	COG0811	peptide transport
ND448_05200	COG0848	biopolymer transport protein
ND448_05205	COG3064	Membrane
ND448_05205	COG3064	Membrane
ND448_05210	COG0823	Involved in the tonB-independent uptake of proteins
ND448_05215	COG2885	chlorophyll binding
ND448_05220	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND448_05250	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND448_05260	COG2205	protein histidine kinase activity
ND448_05260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND448_05270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND448_05275	COG0588	phosphoglycerate mutase activity
ND448_05285	COG2017	converts alpha-aldose to the beta-anomer
ND448_05295	COG1085	galactose-1-phosphate uridylyltransferase
ND448_05300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND448_05315	COG3585	molybdate ion transport
ND448_05315	COG2005	Transcriptional regulator
ND448_05325	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND448_05330	COG4149	molybdate abc transporter
ND448_05340	COG0561	phosphatase activity
ND448_05345	COG2706	6-phosphogluconolactonase activity
ND448_05360	COG0156	8-amino-7-oxononanoate synthase activity
ND448_05365	COG2226	methyltransferase
ND448_05380	COG0556	nucleotide-excision repair
ND448_05385	COG4628	conserved protein (DUF2132)
ND448_05400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND448_05405	COG1120	ATPase activity
ND448_05410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND448_05415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND448_05425	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND448_05430	COG0314	molybdopterin synthase activity
ND448_05435	COG0670	Belongs to the BI1 family
ND448_05440	COG0842	Transport permease protein
ND448_05445	COG0842	Transport permease protein
ND448_05450	COG1131	(ABC) transporter
ND448_05455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND448_05460	COG1309	transcriptional regulator
ND448_05465	COG0513	Belongs to the DEAD box helicase family
ND448_05470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND448_05480	COG1686	Belongs to the peptidase S11 family
ND448_05485	COG0277	FAD linked oxidase domain protein
ND448_05505	COG2261	transglycosylase associated protein
ND448_05515	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND448_05525	COG3639	organic phosphonate transmembrane transporter activity
ND448_05530	COG4807	Protein conserved in bacteria
ND448_05535	COG2897	thiosulfate sulfurtransferase activity
ND448_05540	COG1732	Glycine betaine
ND448_05545	COG1174	glycine betaine transport
ND448_05550	COG1125	glycine betaine transport
ND448_05555	COG1174	glycine betaine transport
ND448_05560	COG0531	amino acid
ND448_05565	COG1982	Orn Lys Arg decarboxylase major
ND448_05575	COG0697	spore germination
ND448_05590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND448_05595	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND448_05600	COG1126	abc transporter atp-binding protein
ND448_05605	COG0765	amino acid transport
ND448_05610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND448_05630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND448_05635	COG2239	Acts as a magnesium transporter
ND448_05640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND448_05645	COG0488	(ABC) transporter
ND448_05650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND448_05655	COG0303	'Molybdopterin
ND448_05675	COG0583	DNA-binding transcription factor activity
ND448_05680	COG0477	Major facilitator Superfamily
ND448_05685	COG0302	gtp cyclohydrolase
ND448_05690	COG2311	Membrane
ND448_05715	COG2949	membrane
ND448_05720	COG0281	malic enzyme
ND448_05730	COG0583	DNA-binding transcription factor activity
ND448_05740	COG1346	cytolysis
ND448_05745	COG1380	Effector of murein hydrolase LrgA
ND448_05755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND448_05755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND448_05760	COG0489	protein tyrosine kinase activity
ND448_05765	COG0572	uridine kinase
ND448_05770	COG0717	Belongs to the dCTP deaminase family
ND448_05775	COG2982	Protein involved in outer membrane biogenesis
ND448_05780	COG3069	C4-dicarboxylate transmembrane transporter activity
ND448_05785	COG1253	flavin adenine dinucleotide binding
ND448_05790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND448_05795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND448_05800	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND448_05810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND448_05810	COG0140	phosphoribosyl-ATP diphosphatase activity
ND448_05820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND448_05830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND448_05830	COG0131	Imidazoleglycerol-phosphate dehydratase
ND448_05835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND448_05840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND448_05855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND448_05860	COG0625	glutathione transferase activity
ND448_05875	COG0626	cystathionine gamma-synthase activity
ND448_05885	COG1686	Belongs to the peptidase S11 family
ND448_05890	COG1760	l-serine dehydratase
ND448_05895	COG0814	amino acid
ND448_05900	COG1349	DNA-binding transcription factor activity
ND448_05910	COG0671	phosphoesterase, PA-phosphatase related
ND448_05920	COG0569	domain protein
ND448_05920	COG2985	domain, Protein
ND448_05940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND448_05945	COG3842	ATPase activity
ND448_05950	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND448_05955	COG1177	transmembrane transport
ND448_05970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND448_05975	COG4160	amino acid transport
ND448_05980	COG4215	(ABC) transporter
ND448_05985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND448_05990	COG1126	abc transporter atp-binding protein
ND448_06000	COG0393	Putative heavy-metal-binding
ND448_06005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND448_06010	COG0702	epimerase
ND448_06015	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND448_06020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND448_06025	COG1151	hydroxylamine reductase activity
ND448_06030	COG2431	L-lysine efflux transmembrane transporter activity
ND448_06035	COG3593	DNA synthesis involved in DNA repair
ND448_06040	COG2990	Protein conserved in bacteria
ND448_06045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND448_06055	COG1278	Cold shock
ND448_06060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND448_06065	COG0542	response to heat
ND448_06070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND448_06080	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND448_06090	COG0492	ferredoxin-NADP+ reductase activity
ND448_06095	COG1522	sequence-specific DNA binding
ND448_06100	COG3107	peptidoglycan biosynthetic process
ND448_06100	COG1674	ftsk spoiiie
ND448_06105	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND448_06110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND448_06115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND448_06120	COG2814	Major facilitator Superfamily
ND448_06125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND448_06130	COG1882	Formate acetyltransferase
ND448_06135	COG2116	formate transmembrane transporter activity
ND448_06140	COG1944	ATP diphosphatase activity
ND448_06145	COG0252	asparaginase activity
ND448_06155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND448_06165	COG0539	negative regulation of cytoplasmic translation
ND448_06175	COG0658	competence protein
ND448_06175	COG2333	competence protein COMEC
ND448_06185	COG1663	tetraacyldisaccharide 4'-kinase activity
ND448_06190	COG5383	Protein conserved in bacteria
ND448_06200	COG1278	Cold shock
ND448_06205	COG2835	tetraacyldisaccharide 4'-kinase activity
ND448_06210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND448_06215	COG3173	Aminoglycoside phosphotransferase
ND448_06220	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND448_06225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND448_06230	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND448_06240	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND448_06245	COG2989	Protein conserved in bacteria
ND448_06250	COG3108	Peptidase M15
ND448_06255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND448_06260	COG1448	Aminotransferase
ND448_06275	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND448_06280	COG0308	aminopeptidase N
ND448_06285	COG0167	dihydroorotate dehydrogenase activity
ND448_06295	COG0633	Ferredoxin
ND448_06295	COG3217	Mosc domain protein beta barrel domain protein
ND448_06300	COG0116	Belongs to the methyltransferase superfamily
ND448_06300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND448_06305	COG0488	(ABC) transporter
ND448_06310	COG2995	paraquat-inducible protein a
ND448_06315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND448_06315	COG3008	intermembrane lipid transfer
ND448_06320	COG3009	Protein conserved in bacteria
ND448_06325	COG3130	regulation of translation
ND448_06330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND448_06335	COG1067	ATP-dependent peptidase activity
ND448_06340	COG3120	sequence-specific DNA binding
ND448_06350	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND448_06355	COG3070	regulator of competence-specific genes
ND448_06360	COG1289	transmembrane transporter activity
ND448_06365	COG3304	Inner membrane component domain
ND448_06370	COG0210	DNA helicase
ND448_06375	COG1803	Methylglyoxal synthase
ND448_06385	COG1832	CoA-binding protein
ND448_06390	COG3785	DNA binding
ND448_06395	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND448_06400	COG1254	Belongs to the acylphosphatase family
ND448_06405	COG2920	part of a sulfur-relay system
ND448_06415	COG0288	reversible hydration of carbon dioxide
ND448_06435	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND448_06440	COG2943	transferase activity, transferring hexosyl groups
ND448_06455	COG0675	Transposase, IS605 OrfB family
ND448_06470	COG1560	Kdo2-lipid A biosynthetic process
ND448_06480	COG0628	permease
ND448_06505	COG0418	dihydroorotase activity
ND448_06510	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND448_06520	COG1530	ribonuclease E activity
ND448_06525	COG0564	pseudouridine synthase activity
ND448_06530	COG0424	maF-like protein
ND448_06535	COG1399	metal-binding, possibly nucleic acid-binding protein
ND448_06540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND448_06550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND448_06555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND448_06565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND448_06570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND448_06575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND448_06580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND448_06585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND448_06590	COG0470	DNA polymerase III
ND448_06595	COG0084	hydrolase, TatD family'
ND448_06600	COG1263	PTS System
ND448_06600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND448_06605	COG0537	adenosine 5'-monophosphoramidase activity
ND448_06610	COG5633	Lipoprotein
ND448_06615	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND448_06630	COG3150	esterase
ND448_06635	COG1252	NADH dehydrogenase
ND448_06640	COG3134	Outer membrane lipoprotein
ND448_06645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND448_06650	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND448_06660	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND448_06680	COG2850	peptidyl-arginine hydroxylation
ND448_06685	COG2205	protein histidine kinase activity
ND448_06690	COG0745	RESPONSE REGULATOR receiver
ND448_06700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND448_06705	COG2915	High frequency lysogenization protein hflD homolog
ND448_06710	COG0482	sulfurtransferase activity
ND448_06720	COG1187	pseudouridine synthase activity
ND448_06725	COG0538	isocitrate dehydrogenase activity
ND448_06730	COG2771	luxR family
ND448_06735	COG3916	Acyl-homoserine-lactone synthase
ND448_06740	COG2723	6-phospho-beta-galactosidase activity
ND448_06750	COG0339	signal peptide processing
ND448_06755	COG0840	transmembrane signaling receptor activity
ND448_06780	COG0675	Transposase, IS605 OrfB family
ND448_06790	COG4565	transcriptional regulatory protein
ND448_06795	COG3290	protein histidine kinase activity
ND448_06800	COG0471	metal ion transport
ND448_06840	COG4977	sequence-specific DNA binding
ND448_06845	COG1702	phosphate starvation-inducible protein PhoH
ND448_06850	COG0387	Pfam Sodium calcium exchanger
ND448_06855	COG2375	cellular response to nickel ion
ND448_06860	COG3850	Histidine kinase
ND448_06870	COG1294	oxidase, subunit
ND448_06875	COG1271	oxidase subunit
ND448_06880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND448_06885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND448_06890	COG3138	arginine N-succinyltransferase
ND448_06900	COG3724	N-succinylarginine dihydrolase activity
ND448_06920	COG1228	amidohydrolase
ND448_06930	COG0402	S-adenosylhomocysteine deaminase activity
ND448_06950	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND448_06955	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND448_06960	COG3383	formate dehydrogenase (NAD+) activity
ND448_06965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND448_06970	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND448_06980	COG3260	NADH ubiquinone oxidoreductase 20
ND448_06985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND448_06990	COG3261	NADH dehydrogenase
ND448_06990	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND448_06995	COG0650	Formate hydrogenlyase subunit 4
ND448_07000	COG0651	ATP synthesis coupled electron transport
ND448_07005	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND448_07015	COG0375	protein maturation
ND448_07020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND448_07025	COG0298	carbon dioxide binding
ND448_07030	COG0409	Hydrogenase expression formation protein
ND448_07035	COG0309	Hydrogenase expression formation protein (HypE)
ND448_07070	COG2207	Transcriptional regulator
ND448_07070	COG3708	Transcriptional regulator
ND448_07075	COG0012	GTP binding
ND448_07085	COG0193	aminoacyl-tRNA hydrolase activity
ND448_07095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND448_07105	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND448_07110	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND448_07115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND448_07120	COG2890	protein-(glutamine-N5) methyltransferase activity
ND448_07135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND448_07140	COG0659	secondary active sulfate transmembrane transporter activity
ND448_07145	COG3706	GGDEF domain
ND448_07170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND448_07180	COG3381	protein complex oligomerization
ND448_07200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND448_07210	COG0673	inositol 2-dehydrogenase activity
ND448_07215	COG0728	peptidoglycan biosynthetic process
ND448_07240	COG3102	Protein conserved in bacteria
ND448_07245	COG3142	Participates in the control of copper homeostasis
ND448_07260	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND448_07265	COG1801	Protein of unknown function DUF72
ND448_07275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND448_07280	COG0494	nUDIX hydrolase
ND448_07290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND448_07300	COG2255	four-way junction helicase activity
ND448_07305	COG3104	oligopeptide transport
ND448_07310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND448_07315	COG1121	(ABC) transporter
ND448_07320	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND448_07325	COG0739	heme binding
ND448_07330	COG1560	Kdo2-lipid A biosynthetic process
ND448_07335	COG0469	pyruvate kinase activity
ND448_07340	COG1737	Transcriptional regulator
ND448_07345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND448_07350	COG0800	Aldolase
ND448_07360	COG2076	Multidrug Resistance protein
ND448_07365	COG0251	oxidation-reduction process
ND448_07370	COG1199	ATP-dependent helicase activity
ND448_07375	COG1214	PFAM Peptidase M22, glycoprotease
ND448_07380	COG3065	identical protein binding
ND448_07385	COG0318	PFAM AMP-dependent synthetase and ligase
ND448_07390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND448_07395	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND448_07400	COG2894	cell division
ND448_07405	COG0850	regulation of cytokinetic process
ND448_07410	COG3100	YcgL domain-containing protein
ND448_07415	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND448_07420	COG2983	Belongs to the UPF0260 family
ND448_07440	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND448_07450	COG2719	SpoVR family
ND448_07455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND448_07460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND448_07465	COG2814	Major facilitator Superfamily
ND448_07475	COG2199	diguanylate cyclase activity
ND448_07475	COG2200	EAL domain
ND448_07475	COG2202	Pas domain
ND448_07495	COG2718	Belongs to the UPF0229 family
ND448_07500	COG2766	serine protein kinase
ND448_07510	COG3713	MltA-interacting MipA family protein
ND448_07515	COG2194	sulfuric ester hydrolase activity
ND448_07530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND448_07535	COG3139	Protein of unknown function (DUF1315)
ND448_07540	COG1335	isochorismatase
ND448_07545	COG0252	asparaginase activity
ND448_07550	COG0616	signal peptide processing
ND448_07555	COG0778	Nitroreductase
ND448_07565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND448_07575	COG0494	nUDIX hydrolase
ND448_07580	COG0708	Exodeoxyribonuclease III
ND448_07610	COG0788	formyltetrahydrofolate deformylase activity
ND448_07620	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND448_07625	COG0745	RESPONSE REGULATOR receiver
ND448_07645	COG1012	belongs to the aldehyde dehydrogenase family
ND448_07645	COG1454	alcohol dehydrogenase
ND448_07655	COG2095	MarC family integral membrane protein
ND448_07660	COG4166	transmembrane transport
ND448_07675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND448_07690	COG3099	Belongs to the UPF0263 family
ND448_07695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND448_07715	COG2350	Protein conserved in bacteria
ND448_07730	COG3710	Transcriptional regulator
ND448_07765	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND448_07790	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND448_07795	COG3047	cAMP biosynthetic process
ND448_07810	COG0133	tryptophan synthase activity
ND448_07815	COG0134	indole-3-glycerol-phosphate synthase activity
ND448_07815	COG0135	phosphoribosylanthranilate isomerase activity
ND448_07825	COG0512	Glutamine amidotransferase of anthranilate synthase
ND448_07835	COG0613	PHP domain protein
ND448_07840	COG0009	L-threonylcarbamoyladenylate synthase
ND448_07860	COG1187	pseudouridine synthase activity
ND448_07870	COG1028	Short-chain dehydrogenase reductase Sdr
ND448_07875	COG0616	signal peptide processing
ND448_07890	COG0583	DNA-binding transcription factor activity
ND448_07905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND448_07915	COG0671	phosphoesterase, PA-phosphatase related
ND448_07920	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND448_07925	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND448_07945	COG0023	Translation Initiation Factor
ND448_07955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND448_07960	COG3447	MASE1 domain protein
ND448_07960	COG5001	Diguanylate cyclase
ND448_07960	COG5002	protein histidine kinase activity
ND448_07965	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND448_07970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND448_07980	COG4659	FMN binding
ND448_07990	COG2207	Transcriptional regulator
ND448_07990	COG3708	Transcriptional regulator
ND448_08005	COG4657	Part of a membrane complex involved in electron transport
ND448_08015	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND448_08025	COG0673	inositol 2-dehydrogenase activity
ND448_08030	COG0385	Bile acid
ND448_08035	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND448_08040	COG5339	Protein conserved in bacteria
ND448_08045	COG1482	cell wall glycoprotein biosynthetic process
ND448_08050	COG0114	fumarate hydratase activity
ND448_08060	COG1940	carbohydrate kinase activity
ND448_08065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND448_08085	COG1742	UPF0060 membrane protein
ND448_08090	COG4221	oxidoreductase activity
ND448_08095	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND448_08115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND448_08155	COG1011	Hydrolase
ND448_08165	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND448_08170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND448_08175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND448_08180	COG0589	response to stress
ND448_08210	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND448_08215	COG3623	hexulose-6-phosphate isomerase
ND448_08220	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND448_08225	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND448_08235	COG0531	amino acid
ND448_08245	COG0745	RESPONSE REGULATOR receiver
ND448_08250	COG2205	protein histidine kinase activity
ND448_08265	COG2207	Transcriptional regulator
ND448_08270	COG1881	PFAM PEBP family protein
ND448_08280	COG3591	Belongs to the peptidase S1B family
ND448_08285	COG1643	Atp-dependent helicase
ND448_08290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND448_08295	COG3784	Protein of unknown function (DUF1318)
ND448_08310	COG2911	Protein conserved in bacteria
ND448_08315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND448_08320	COG3187	Heat shock protein
ND448_08325	COG3042	response to heat
ND448_08330	COG1285	pathogenesis
ND448_08340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND448_08340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND448_08340	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND448_08340	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND448_08355	COG4166	transmembrane transport
ND448_08360	COG2866	Carboxypeptidase
ND448_08365	COG4948	Mandelate Racemase Muconate Lactonizing
ND448_08370	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND448_08380	COG5642	Protein of unknown function (DUF2384)
ND448_08385	COG5654	RES domain protein
ND448_08390	COG3768	UPF0283 membrane protein
ND448_08395	COG3106	COG3106 Predicted ATPase
ND448_08405	COG1983	PspC domain protein
ND448_08415	COG1842	Phage shock protein A
ND448_08420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND448_08435	COG4166	transmembrane transport
ND448_08445	COG4171	peptide transport system, permease
ND448_08450	COG4172	Belongs to the ABC transporter superfamily
ND448_08455	COG4172	Belongs to the ABC transporter superfamily
ND448_08465	COG3104	oligopeptide transport
ND448_08475	COG0484	heat shock protein binding
ND448_08520	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND448_08525	COG3133	Outer membrane lipoprotein
ND448_08530	COG1846	Transcriptional regulator
ND448_08540	COG4989	oxidoreductase activity
ND448_08545	COG3313	Fe-S protein
ND448_08550	COG2194	sulfuric ester hydrolase activity
ND448_08555	COG1309	transcriptional regulator
ND448_08560	COG1902	pentaerythritol trinitrate reductase activity
ND448_08575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND448_08580	COG0791	NLP P60 protein
ND448_08585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND448_08595	COG1609	Transcriptional regulator
ND448_08600	COG0583	DNA-binding transcription factor activity
ND448_08605	COG2814	Major facilitator Superfamily
ND448_08610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND448_08615	COG0307	riboflavin synthase, alpha
ND448_08650	COG1376	ErfK ybiS ycfS ynhG family protein
ND448_08650	COG1388	LysM domain
ND448_08655	COG2166	iron-sulfur cluster assembly
ND448_08665	COG0719	Fe-S assembly protein
ND448_08670	COG0396	ATPase activity
ND448_08675	COG0719	Fe-S assembly protein
ND448_08680	COG0316	Belongs to the HesB IscA family
ND448_08685	COG2050	protein possibly involved in aromatic compounds catabolism
ND448_08690	COG0277	FAD linked oxidase domain protein
ND448_08690	COG0247	lactate metabolic process
ND448_08695	COG0628	permease
ND448_08705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND448_08705	COG0574	Belongs to the PEP-utilizing enzyme family
ND448_08710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND448_08715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND448_08725	COG4771	TonB-dependent receptor
ND448_08730	COG3720	iron ion transport
ND448_08735	COG4558	Periplasmic binding protein
ND448_08740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND448_08745	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND448_08755	COG0095	Lipoate-protein ligase
ND448_08760	COG0791	NLP P60 protein
ND448_08765	COG2076	Multidrug Resistance protein
ND448_08770	COG2076	Multidrug Resistance protein
ND448_08775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND448_08790	COG0463	Glycosyl transferase, family 2
ND448_08795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND448_08805	COG4139	cobalamin transport
ND448_08850	COG2184	nucleotidyltransferase activity
ND448_08865	COG2314	TM2 domain
ND448_08870	COG0776	regulation of translation
ND448_08940	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND448_08945	COG1121	(ABC) transporter
ND448_08950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND448_08955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND448_08960	COG3001	Fructosamine kinase
ND448_08970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND448_08975	COG1988	membrane-bound metal-dependent
ND448_08980	COG1823	symporter activity
ND448_08985	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND448_08995	COG2814	Major facilitator Superfamily
ND448_09005	COG0501	Belongs to the peptidase M48B family
ND448_09010	COG0793	Belongs to the peptidase S41A family
ND448_09020	COG1956	GAF domain-containing protein
ND448_09025	COG2995	paraquat-inducible protein a
ND448_09030	COG3008	intermembrane lipid transfer
ND448_09035	COG4251	negative regulation of phosphorylation
ND448_09035	COG5001	Diguanylate cyclase
ND448_09035	COG2203	Gaf domain
ND448_09035	COG3706	GGDEF domain
ND448_09245	COG3772	lysozyme
ND448_09295	COG1674	ftsk spoiiie
ND448_09295	COG1178	ABC-type Fe3 transport system permease component
ND448_09415	COG1276	copper resistance
ND448_09420	COG2372	response to copper ion
ND448_09425	COG1528	Iron-storage protein
ND448_09445	COG1770	oligopeptidase
ND448_09455	COG3097	Belongs to the UPF0267 family
ND448_09460	COG3141	response to X-ray
ND448_09465	COG0513	Belongs to the DEAD box helicase family
ND448_09485	COG0494	nUDIX hydrolase
ND448_09490	COG1760	l-serine dehydratase
ND448_09495	COG1253	flavin adenine dinucleotide binding
ND448_09500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND448_09500	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND448_09505	COG3715	PTS system
ND448_09510	COG3716	PTS system mannose fructose sorbose family IID component
ND448_09515	COG4811	Protein of unknown function (DUF986)
ND448_09520	COG1971	Probably functions as a manganese efflux pump
ND448_09540	COG1960	acyl-CoA dehydrogenase activity
ND448_09550	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND448_09580	COG2226	methyltransferase
ND448_09585	COG0768	penicillin binding
ND448_09590	COG1496	oxidoreductase activity
ND448_09610	COG1113	amino acid transport
ND448_09645	COG2207	Transcriptional regulator
ND448_09665	COG1132	(ABC) transporter
ND448_09675	COG2203	Gaf domain
ND448_09675	COG3706	GGDEF domain
ND448_09675	COG4251	negative regulation of phosphorylation
ND448_09675	COG5001	Diguanylate cyclase
ND448_09695	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND448_09715	COG1278	Cold shock
ND448_09720	COG1278	Cold shock
ND448_09725	COG1278	Cold shock
ND448_09740	COG2169	Transcriptional regulator
ND448_09740	COG1917	Cupin 2, conserved barrel domain protein
ND448_09745	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND448_09750	COG2723	6-phospho-beta-galactosidase activity
ND448_09755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND448_09760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND448_09765	COG1187	pseudouridine synthase activity
ND448_09775	COG3122	Protein conserved in bacteria
ND448_09780	COG1757	Na H antiporter
ND448_09795	COG2235	arginine
ND448_09810	COG0076	glutamate decarboxylase activity
ND448_09815	COG0531	amino acid
ND448_09850	COG2153	protein acetylation
ND448_09855	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND448_09885	COG0840	transmembrane signaling receptor activity
ND448_09890	COG2801	Transposase and inactivated derivatives
ND448_09910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND448_09915	COG0322	excinuclease ABC activity
ND448_09920	COG2197	response regulator
ND448_09945	COG1113	amino acid transport
ND448_09955	COG0531	amino acid
ND448_09960	COG3710	Transcriptional regulator
ND448_09965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND448_09970	COG0506	proline dehydrogenase activity
ND448_09970	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND448_09970	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND448_09975	COG1126	abc transporter atp-binding protein
ND448_09980	COG0765	amino acid transport
ND448_09985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND448_09990	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND448_10000	COG1191	sigma factor activity
ND448_10040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND448_10045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND448_10055	COG1677	Flagellar hook-basal body complex protein FliE
ND448_10065	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND448_10070	COG1317	bacterial-type flagellum organization
ND448_10075	COG1157	protein secretion by the type III secretion system
ND448_10090	COG1580	Controls the rotational direction of flagella during chemotaxis
ND448_10170	COG1558	bacterial-type flagellum-dependent cell motility
ND448_10175	COG1815	bacterial-type flagellum-dependent cell motility
ND448_10185	COG2747	anti-sigma28 factor FlgM
ND448_10190	COG3418	PFAM FlgN family protein
ND448_10200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND448_10205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND448_10210	COG1404	Belongs to the peptidase S8 family
ND448_10210	COG4935	Belongs to the peptidase S8 family
ND448_10215	COG2197	response regulator
ND448_10230	COG3188	usher protein
ND448_10235	COG3121	Chaperone
ND448_10245	COG3539	Fimbrial protein
ND448_10275	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND448_10280	COG0745	RESPONSE REGULATOR receiver
ND448_10290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND448_10295	COG0840	transmembrane signaling receptor activity
ND448_10300	COG0840	transmembrane signaling receptor activity
ND448_10305	COG0835	chemotaxis
ND448_10310	COG0643	Histidine kinase
ND448_10310	COG2198	Histidine kinase
ND448_10315	COG1360	Flagellar Motor Protein
ND448_10335	COG0589	response to stress
ND448_10340	COG1285	pathogenesis
ND448_10345	COG0840	transmembrane signaling receptor activity
ND448_10365	COG1609	Transcriptional regulator
ND448_10375	COG1028	Short-chain dehydrogenase reductase Sdr
ND448_10375	COG0604	alcohol dehydrogenase
ND448_10375	COG3321	synthase
ND448_10410	COG0582	viral genome integration into host DNA
ND448_10425	COG3423	Transcriptional regulator
ND448_10460	COG3451	type IV secretory pathway VirB4
ND448_10480	COG3736	Type IV secretory pathway, component VirB8
ND448_10495	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ND448_10510	COG4227	nucleotidyltransferase activity
ND448_10575	COG0471	metal ion transport
ND448_10590	COG3051	citrate lyase alpha subunit
ND448_10595	COG2301	Belongs to the HpcH HpaI aldolase family
ND448_10600	COG3052	prosthetic group binding
ND448_10605	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND448_10610	COG3290	protein histidine kinase activity
ND448_10615	COG4565	transcriptional regulatory protein
ND448_10630	COG2271	Major facilitator Superfamily
ND448_10635	COG1840	ABC-type Fe3 transport system, periplasmic component
ND448_10645	COG3842	ATPase activity
ND448_10665	COG1289	transmembrane transporter activity
ND448_10675	COG2925	Exonuclease
ND448_10680	COG0531	amino acid
ND448_10685	COG4771	TonB-dependent receptor
ND448_10695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND448_10705	COG0833	amino acid
ND448_10710	COG0583	DNA-binding transcription factor activity
ND448_10720	COG2855	membrane
ND448_10725	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND448_10730	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND448_10730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND448_10730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND448_10735	COG1105	Belongs to the carbohydrate kinase PfkB family
ND448_10750	COG3005	denitrification pathway
ND448_10755	COG0243	molybdopterin cofactor binding
ND448_10775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND448_10785	COG0246	Mannitol dehydrogenase
ND448_10795	COG0523	cobalamin synthesis protein
ND448_10800	COG0671	phosphoesterase, PA-phosphatase related
ND448_10805	COG0791	NLP P60 protein
ND448_10810	COG2200	EAL domain
ND448_10815	COG4166	transmembrane transport
ND448_10820	COG4174	ABC transporter (Permease)
ND448_10825	COG4239	(ABC) transporter, permease
ND448_10830	COG4172	Belongs to the ABC transporter superfamily
ND448_10840	COG2814	Major facilitator Superfamily
ND448_10845	COG1187	pseudouridine synthase activity
ND448_10850	COG1061	Type III restriction enzyme res subunit
ND448_10865	COG3082	Protein of unknown function (DUF1414)
ND448_10870	COG3083	sulfuric ester hydrolase activity
ND448_10895	COG3778	Protein conserved in bacteria
ND448_10900	COG3299	homolog of phage Mu protein gp47
ND448_10945	COG4386	tail sheath protein
ND448_10995	COG4626	Terminase
ND448_10995	COG1802	Transcriptional regulator
ND448_11020	COG1876	peptidase activity
ND448_11050	COG2815	serine threonine protein kinase
ND448_11050	COG0515	serine threonine protein kinase
ND448_11065	COG1403	HNH endonuclease
ND448_11080	COG4725	Belongs to the MT-A70-like family
ND448_11085	COG4626	Terminase
ND448_11085	COG1802	Transcriptional regulator
ND448_11120	COG5532	Uncharacterized conserved protein (DUF2303)
ND448_11125	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND448_11175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND448_11180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND448_11200	COG2223	nitrite transmembrane transporter activity
ND448_11205	COG2198	Histidine kinase
ND448_11205	COG0642	Histidine kinase
ND448_11215	COG2205	protein histidine kinase activity
ND448_11215	COG0784	Response regulator, receiver
ND448_11225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND448_11230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND448_11240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND448_11250	COG4574	serine-type endopeptidase inhibitor activity
ND448_11260	COG2246	polysaccharide biosynthetic process
ND448_11275	COG0814	amino acid
ND448_11300	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND448_11305	COG0596	Alpha beta hydrolase
ND448_11310	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND448_11315	COG1169	isochorismate synthase
ND448_11320	COG4575	ribosome binding
ND448_11335	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND448_11340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND448_11350	COG0839	Belongs to the complex I subunit 6 family
ND448_11355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND448_11360	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND448_11365	COG1034	ATP synthesis coupled electron transport
ND448_11385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND448_11390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND448_11395	COG0583	DNA-binding transcription factor activity
ND448_11400	COG0436	Aminotransferase
ND448_11405	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND448_11410	COG0490	domain, Protein
ND448_11410	COG0471	metal ion transport
ND448_11420	COG3013	Belongs to the UPF0304 family
ND448_11425	COG3092	negative regulation of chromosome organization
ND448_11435	COG0857	belongs to the CobB CobQ family
ND448_11435	COG0280	phosphate acetyltransferase
ND448_11440	COG1609	Transcriptional regulator
ND448_11455	COG3037	sugar-specific permease SgaT UlaA
ND448_11460	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND448_11465	COG0622	Phosphoesterase
ND448_11480	COG0625	glutathione transferase activity
ND448_11485	COG1090	epimerase
ND448_11495	COG4160	amino acid transport
ND448_11500	COG4215	(ABC) transporter
ND448_11515	COG0163	prenyltransferase activity
ND448_11520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND448_11525	COG1286	toxin biosynthetic process
ND448_11530	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND448_11535	COG0285	dihydrofolate synthase activity
ND448_11545	COG0586	Pfam SNARE associated Golgi protein
ND448_11555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND448_11580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND448_11585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND448_11615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND448_11630	COG3101	peptidyl-lysine hydroxylation
ND448_11635	COG0730	response to heat
ND448_11640	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND448_11650	COG2890	protein-(glutamine-N5) methyltransferase activity
ND448_11655	COG2840	Smr protein MutS2
ND448_11660	COG2062	phosphohistidine phosphatase, SixA
ND448_11665	COG1024	Enoyl-CoA hydratase
ND448_11665	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND448_11670	COG0183	Belongs to the thiolase family
ND448_11675	COG3691	Protein conserved in bacteria
ND448_11690	COG3088	subunit of a heme lyase
ND448_11690	COG4235	cytochrome complex assembly
ND448_11695	COG3088	subunit of a heme lyase
ND448_11695	COG4235	cytochrome complex assembly
ND448_11700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND448_11705	COG1138	Cytochrome C-type biogenesis protein
ND448_11710	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND448_11715	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND448_11720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND448_11725	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND448_11740	COG0582	viral genome integration into host DNA
ND448_11745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ND448_11800	COG2824	Alkylphosphonate utilization operon protein PhnA
ND448_11805	COG2951	lytic endotransglycosylase activity
ND448_11810	COG1598	PFAM Uncharacterised protein family UPF0150
ND448_11820	COG3038	cytochrome b561
ND448_11825	COG0436	Aminotransferase
ND448_11835	COG3275	phosphorelay sensor kinase activity
ND448_11840	COG3279	Response regulator of the LytR AlgR family
ND448_11845	COG2223	nitrite transmembrane transporter activity
ND448_11850	COG0837	glucose binding
ND448_11870	COG1914	H( )-stimulated, divalent metal cation uptake system
ND448_11875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND448_11935	COG3530	Putative quorum-sensing-regulated virulence factor
ND448_11940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND448_11950	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND448_11960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND448_11975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND448_11985	COG4208	sulfate ABC transporter
ND448_11990	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND448_11995	COG4150	thiosulfate binding
ND448_12005	COG1737	Transcriptional regulator
ND448_12010	COG2731	YhcH YjgK YiaL family protein
ND448_12025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND448_12030	COG2837	iron assimilation
ND448_12040	COG3111	PFAM Bacterial OB fold (BOF) protein
ND448_12100	COG1671	Belongs to the UPF0178 family
ND448_12105	COG0281	malic enzyme
ND448_12105	COG0280	phosphate acetyltransferase
ND448_12110	COG0494	nUDIX hydrolase
ND448_12115	COG3005	denitrification pathway
ND448_12120	COG3043	anaerobic respiration
ND448_12125	COG0243	molybdopterin cofactor binding
ND448_12130	COG3062	negative regulation of establishment of protein localization
ND448_12135	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND448_12135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND448_12140	COG2197	response regulator
ND448_12150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND448_12160	COG1605	Chorismate mutase
ND448_12165	COG1393	Belongs to the ArsC family
ND448_12170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND448_12175	COG1876	peptidase activity
ND448_12185	COG0400	carboxylic ester hydrolase activity
ND448_12205	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND448_12210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND448_12215	COG2716	regulation of RNA biosynthetic process
ND448_12220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND448_12225	COG0628	permease
ND448_12230	COG4783	chaperone-mediated protein folding
ND448_12235	COG1393	Belongs to the ArsC family
ND448_12240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND448_12245	COG2233	PERMEase
ND448_12250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND448_12255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND448_12260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND448_12265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND448_12275	COG0581	inorganic phosphate transmembrane transporter activity
ND448_12280	COG0573	inorganic phosphate transmembrane transporter activity
ND448_12285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND448_12300	COG2239	Acts as a magnesium transporter
ND448_12305	COG0443	Heat shock 70 kDa protein
ND448_12315	COG3121	Chaperone
ND448_12335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND448_12345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND448_12350	COG0477	Major facilitator Superfamily
ND448_12355	COG2205	protein histidine kinase activity
ND448_12360	COG0745	RESPONSE REGULATOR receiver
ND448_12365	COG3422	double-strand break repair
ND448_12370	COG0826	peptidase U32
ND448_12375	COG1597	lipid kinase activity
ND448_12390	COG0351	phosphomethylpyrimidine kinase
ND448_12405	COG0519	Catalyzes the synthesis of GMP from XMP
ND448_12405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND448_12410	COG0517	IMP dehydrogenase activity
ND448_12410	COG0516	GMP reductase activity
ND448_12415	COG1570	exodeoxyribonuclease VII activity
ND448_12420	COG1645	bacterial-type flagellum-dependent swarming motility
ND448_12430	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND448_12435	COG2976	Protein conserved in bacteria
ND448_12440	COG0124	histidyl-tRNA synthetase
ND448_12460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND448_12475	COG4953	penicillin-binding protein 1C
ND448_12480	COG2373	Large extracellular alpha-helical protein
ND448_12495	COG2975	iron-sulfur cluster assembly
ND448_12500	COG0633	Ferredoxin
ND448_12505	COG0443	Heat shock 70 kDa protein
ND448_12520	COG0822	iron-sulfur transferase activity
ND448_12530	COG1959	2 iron, 2 sulfur cluster binding
ND448_12535	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND448_12545	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND448_12550	COG3683	transport system, periplasmic component
ND448_12555	COG3711	transcriptional antiterminator
ND448_12560	COG2814	Major facilitator Superfamily
ND448_12570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND448_12570	COG1017	nitric oxide dioxygenase activity
ND448_12575	COG2188	Transcriptional regulator
ND448_12585	COG3457	Alanine racemase
ND448_12590	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND448_12605	COG0347	Belongs to the P(II) protein family
ND448_12610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND448_12610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND448_12615	COG2204	response regulator
ND448_12620	COG3170	Tfp pilus assembly protein FimV
ND448_12625	COG2205	protein histidine kinase activity
ND448_12640	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND448_12650	COG0560	Phosphoserine phosphatase
ND448_12655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND448_12655	COG1263	PTS System
ND448_12665	COG1737	Transcriptional regulator
ND448_12670	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND448_12680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND448_12690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND448_12705	COG0481	GTPase activity
ND448_12710	COG3086	response to oxidative stress
ND448_12720	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND448_12730	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND448_12740	COG0513	Belongs to the DEAD box helicase family
ND448_12755	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND448_12765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND448_12770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND448_12775	COG0497	DNA recombination
ND448_12780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND448_12790	COG2867	negative regulation of translational initiation
ND448_12795	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND448_12805	COG0582	viral genome integration into host DNA
ND448_12835	COG3596	GTP binding
ND448_12840	COG2378	regulation of single-species biofilm formation
ND448_12850	COG2378	regulation of single-species biofilm formation
ND448_12875	COG2003	Belongs to the UPF0758 family
ND448_12930	COG3121	Chaperone
ND448_12935	COG3188	usher protein
ND448_12960	COG0583	DNA-binding transcription factor activity
ND448_13035	COG1069	ribulokinase activity
ND448_13045	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND448_13050	COG1129	ABC transporter
ND448_13070	COG1620	l-lactate permease
ND448_13075	COG1304	FMN binding
ND448_13080	COG0579	oxidoreductase
ND448_13085	COG1278	Cold shock
ND448_13115	COG1780	Probably involved in ribonucleotide reductase function
ND448_13120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND448_13130	COG4175	Glycine betaine
ND448_13135	COG4176	ABC-type proline glycine betaine transport system permease component
ND448_13140	COG2113	Glycine betaine
ND448_13150	COG2814	Major facilitator Superfamily
ND448_13155	COG1846	Transcriptional regulator
ND448_13165	COG1566	PFAM secretion protein HlyD family protein
ND448_13170	COG2814	Major facilitator Superfamily
ND448_13175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND448_13180	COG3118	belongs to the thioredoxin family
ND448_13185	COG3148	PFAM DTW domain containing protein
ND448_13190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND448_13190	COG0045	succinate-CoA ligase (ADP-forming) activity
ND448_13190	COG1042	CoA-binding domain protein
ND448_13195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND448_13200	COG5544	Lipoprotein
ND448_13225	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND448_13235	COG2011	ABC-type metal ion transport system permease component
ND448_13240	COG1464	Belongs to the NlpA lipoprotein family
ND448_13250	COG1720	tRNA m6t6A37 methyltransferase activity
ND448_13255	COG0442	prolyl-tRNA aminoacylation
ND448_13260	COG3015	lipoprotein NlpE involved in copper resistance
ND448_13270	COG4681	YaeQ
ND448_13280	COG4568	rho-dependent transcription termination
ND448_13295	COG0346	lactoylglutathione lyase activity
ND448_13310	COG0825	malonyl-CoA metabolic process
ND448_13315	COG0587	DNA-directed DNA polymerase activity
ND448_13320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND448_13340	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND448_13345	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND448_13355	COG0750	zinc metalloprotease
ND448_13360	COG0575	Belongs to the CDS family
ND448_13380	COG0528	UMP kinase activity
ND448_13385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND448_13400	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND448_13405	COG2171	N-acyltransferase activity
ND448_13420	COG0564	pseudouridine synthase activity
ND448_13425	COG3098	single-species biofilm formation
ND448_13440	COG1611	Belongs to the LOG family
ND448_13450	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND448_13455	COG2363	Small membrane protein
ND448_13460	COG0583	DNA-binding transcription factor activity
ND448_13470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND448_13475	COG2166	iron-sulfur cluster assembly
ND448_13480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND448_13485	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND448_13505	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND448_13510	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND448_13510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND448_13515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND448_13520	COG1074	ATP-dependent DNA helicase activity
ND448_13525	COG1025	Belongs to the peptidase M16 family
ND448_13530	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND448_13535	COG4967	type IV pilus modification protein PilV
ND448_13560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND448_13565	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND448_13575	COG3066	DNA modification
ND448_13580	COG0861	Integral membrane protein TerC family
ND448_13585	COG0667	Aldo Keto reductase
ND448_13590	COG0477	Major facilitator Superfamily
ND448_13595	COG0204	Acyl-transferase
ND448_13595	COG0318	PFAM AMP-dependent synthetase and ligase
ND448_13600	COG1609	Transcriptional regulator
ND448_13610	COG0583	DNA-binding transcription factor activity
ND448_13615	COG0583	DNA-binding transcription factor activity
ND448_13670	COG2165	general secretion pathway protein
ND448_13680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND448_13710	COG1127	ABC transporter
ND448_13715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND448_13725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND448_13735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND448_13740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND448_13745	COG4974	Belongs to the 'phage' integrase family
ND448_13750	COG0716	FMN binding
ND448_13760	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND448_13770	COG1272	protein, Hemolysin III
ND448_13790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND448_13795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND448_13800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND448_13805	COG0006	proline dipeptidase activity
ND448_13815	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND448_13825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND448_13830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND448_13835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND448_13850	COG1279	arginine transmembrane transporter activity
ND448_13860	COG0191	fructose-bisphosphate aldolase activity
ND448_13865	COG0126	phosphoglycerate kinase activity
ND448_13870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND448_13875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND448_13885	COG1166	arginine decarboxylase activity
ND448_13890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND448_13905	COG0640	Transcriptional regulator
ND448_13910	COG3091	SprT-like family
ND448_13915	COG2356	endonuclease I
ND448_13920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND448_13925	COG0189	ligase activity
ND448_13930	COG1678	Uncharacterized ACR, COG1678
ND448_13935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND448_13940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND448_13950	COG2805	Type II/IV secretion system protein
ND448_13955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND448_13960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND448_13965	COG0762	integral membrane protein
ND448_13970	COG1872	DUF167
ND448_13975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND448_13980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND448_13995	COG3171	Protein conserved in bacteria
ND448_14005	COG1194	a g-specific adenine glycosylase
ND448_14010	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND448_14015	COG0741	lytic transglycosylase activity
ND448_14060	COG1105	Belongs to the carbohydrate kinase PfkB family
ND448_14065	COG1882	Formate acetyltransferase
ND448_14070	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND448_14075	COG0814	amino acid
ND448_14090	COG1028	Short-chain dehydrogenase reductase Sdr
ND448_14095	COG3433	isochorismatase activity
ND448_14095	COG1535	isochorismatase
ND448_14100	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND448_14105	COG1169	isochorismate synthase
ND448_14110	COG4592	Periplasmic binding protein
ND448_14120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND448_14125	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND448_14130	COG1120	ATPase activity
ND448_14140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND448_14145	COG3251	PFAM MbtH domain protein
ND448_14155	COG4774	siderophore transport
ND448_14160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND448_14185	COG4964	Belongs to the GSP D family
ND448_14245	COG0848	biopolymer transport protein
ND448_14250	COG0811	peptide transport
ND448_14255	COG0626	cystathionine gamma-synthase activity
ND448_14260	COG0586	Pfam SNARE associated Golgi protein
ND448_14265	COG2207	Transcriptional regulator
ND448_14270	COG1979	alcohol dehydrogenase
ND448_14275	COG0656	L-ascorbic acid biosynthetic process
ND448_14285	COG2132	Multicopper oxidase
ND448_14300	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND448_14305	COG0583	DNA-binding transcription factor activity
ND448_14310	COG0187	DNA topoisomerase II activity
ND448_14315	COG3150	esterase
ND448_14320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND448_14325	COG3151	Protein conserved in bacteria
ND448_14330	COG0494	nUDIX hydrolase
ND448_14335	COG1538	Outer membrane efflux protein
ND448_14340	COG5463	Belongs to the UPF0441 family
ND448_14345	COG0754	glutathionylspermidine amidase activity
ND448_14350	COG3384	dioxygenase
ND448_14355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND448_14370	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND448_14370	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND448_14380	COG3025	triphosphatase activity
ND448_14385	COG4991	sh3 domain protein
ND448_14390	COG0617	tRNA 3'-terminal CCA addition
ND448_14395	COG1968	undecaprenyl-diphosphatase activity
ND448_14400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND448_14405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND448_14410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND448_14415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND448_14420	COG0358	DNA primase activity
ND448_14450	COG1028	Short-chain dehydrogenase reductase Sdr
ND448_14480	COG0463	Glycosyl transferase, family 2
ND448_14515	COG3210	domain, Protein
ND448_14520	COG3210	domain, Protein
ND448_14530	COG2831	hemolysin activation secretion protein
ND448_14535	COG1902	pentaerythritol trinitrate reductase activity
ND448_14535	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND448_14550	COG1451	nucleotide metabolic process
ND448_14555	COG0673	inositol 2-dehydrogenase activity
ND448_14560	COG0861	Integral membrane protein TerC family
ND448_14565	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND448_14575	COG2721	sulfolactate sulfo-lyase activity
ND448_14590	COG2271	Major facilitator Superfamily
ND448_14605	COG0586	Pfam SNARE associated Golgi protein
ND448_14620	COG4575	ribosome binding
ND448_14625	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND448_14635	COG2259	Doxx family
ND448_14640	COG0583	DNA-binding transcription factor activity
ND448_14645	COG1741	Belongs to the pirin family
ND448_14660	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ND448_14675	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND448_14680	COG2823	Periplasmic or secreted lipoprotein
ND448_14685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND448_14690	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND448_14695	COG5002	protein histidine kinase activity
ND448_14695	COG2198	Histidine kinase
ND448_14695	COG0784	Response regulator, receiver
ND448_14700	COG1242	4 iron, 4 sulfur cluster binding
ND448_14705	COG0069	glutamate synthase activity
ND448_14705	COG0067	glutamate synthase
ND448_14705	COG0070	glutamate synthase
ND448_14710	COG0493	'glutamate synthase
ND448_14720	COG2969	positive regulation of protein catabolic process
ND448_14725	COG0625	glutathione transferase activity
ND448_14730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND448_14735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND448_14740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND448_14745	COG3105	Protein conserved in bacteria
ND448_14750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND448_14760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND448_14765	COG5007	Belongs to the BolA IbaG family
ND448_14770	COG3113	response to antibiotic
ND448_14775	COG2854	intermembrane phospholipid transfer
ND448_14780	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND448_14785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND448_14790	COG1127	ABC transporter
ND448_14795	COG0530	calcium, potassium:sodium antiporter activity
ND448_14800	COG0517	IMP dehydrogenase activity
ND448_14800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND448_14805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND448_14810	COG3117	lipopolysaccharide transmembrane transporter activity
ND448_14815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND448_14820	COG1137	ATPase activity
ND448_14825	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND448_14845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND448_14850	COG0540	Belongs to the ATCase OTCase family
ND448_14855	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND448_14865	COG0366	Alpha amylase catalytic
ND448_14870	COG1263	PTS System
ND448_14870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND448_14880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND448_14890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND448_14895	COG3783	Cytochrome b(562)
ND448_14900	COG0312	modulator of DNA gyrase
ND448_14905	COG3028	Belongs to the UPF0307 family
ND448_14910	COG2732	(Barnase) inhibitor
ND448_14915	COG4290	ribonuclease
ND448_14925	COG1289	transmembrane transporter activity
ND448_14930	COG1566	PFAM secretion protein HlyD family protein
ND448_14940	COG0583	DNA-binding transcription factor activity
ND448_14945	COG0312	modulator of DNA gyrase
ND448_14950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND448_14955	COG3164	Protein of unknown function
ND448_14965	COG0424	maF-like protein
ND448_14970	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND448_14975	COG1792	Involved in formation and maintenance of cell shape
ND448_14980	COG1077	Cell shape determining protein MreB Mrl
ND448_14985	COG2200	EAL domain
ND448_14985	COG2199	diguanylate cyclase activity
ND448_14990	COG0604	alcohol dehydrogenase
ND448_14995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND448_15000	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND448_15010	COG0511	ligase activity, forming carbon-carbon bonds
ND448_15015	COG0439	Biotin carboxylase
ND448_15020	COG3924	membrane
ND448_15025	COG4145	pantothenate transmembrane transporter activity
ND448_15030	COG2264	protein methyltransferase activity
ND448_15035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND448_15040	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND448_15050	COG1560	Kdo2-lipid A biosynthetic process
ND448_15060	COG1346	cytolysis
ND448_15065	COG1380	Effector of murein hydrolase LrgA
ND448_15070	COG0583	DNA-binding transcription factor activity
ND448_15075	COG0025	NhaP-type Na H and K H
ND448_15080	COG2252	PERMEase
ND448_15095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND448_15100	COG2315	Protein conserved in bacteria
ND448_15105	COG1448	Aminotransferase
ND448_15130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND448_15135	COG0735	belongs to the Fur family
ND448_15140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND448_15145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND448_15150	COG2937	Belongs to the GPAT DAPAT family
ND448_15170	COG4580	involved in the transport of maltose and maltodextrins
ND448_15185	COG2182	Extracellular solute-binding protein
ND448_15190	COG1175	transmembrane transport
ND448_15195	COG3833	ABC-type maltose transport systems, permease component
ND448_15200	COG3223	Belongs to the PsiE family
ND448_15210	COG0527	aspartate kinase activity
ND448_15225	COG3328	transposase activity
ND448_15250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ND448_15330	COG0583	DNA-binding transcription factor activity
ND448_15370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND448_15410	COG0138	bifunctional purine biosynthesis protein purh
ND448_15415	COG0151	Belongs to the GarS family
ND448_15435	COG1515	deoxyribonuclease V activity
ND448_15440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND448_15445	COG2816	NAD+ diphosphatase activity
ND448_15450	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND448_15465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND448_15470	COG2104	thiamine diphosphate biosynthetic process
ND448_15475	COG2022	thiamine diphosphate biosynthetic process
ND448_15485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND448_15490	COG0085	RNA polymerase activity
ND448_15495	COG0222	ribosome binding
ND448_15500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND448_15510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND448_15515	COG0250	Participates in transcription elongation, termination and antitermination
ND448_15560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND448_15585	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND448_15590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND448_15595	COG1739	Uncharacterized protein family UPF0029
ND448_15605	COG1024	Enoyl-CoA hydratase
ND448_15605	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND448_15615	COG0543	2 iron, 2 sulfur cluster binding
ND448_15630	COG0250	Participates in transcription elongation, termination and antitermination
ND448_15645	COG0805	protein transport
ND448_15650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND448_15655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND448_15660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND448_15665	COG3165	ubiquinone biosynthetic process from chorismate
ND448_15670	COG2226	methyltransferase
ND448_15675	COG1322	Protein conserved in bacteria
ND448_15680	COG0586	Pfam SNARE associated Golgi protein
ND448_15685	COG1966	Carbon starvation protein
ND448_15700	COG0412	Dienelactone hydrolase
ND448_15705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND448_15710	COG0583	DNA-binding transcription factor activity
ND448_15715	COG0697	spore germination
ND448_15725	COG0584	glycerophosphoryl diester phosphodiesterase
ND448_15735	COG0395	ABC-type sugar transport system, permease component
ND448_15740	COG1175	transmembrane transport
ND448_15745	COG1653	transport
ND448_15780	COG0410	ABC transporter
ND448_15790	COG4177	L-phenylalanine transmembrane transporter activity
ND448_15810	COG1929	Belongs to the glycerate kinase type-1 family
ND448_15815	COG2610	gluconate transmembrane transporter activity
ND448_15820	COG3835	regulator
ND448_15830	COG2177	Part of the ABC transporter FtsEX involved in
ND448_15835	COG2884	Cell division ATP-binding protein ftsE
ND448_15840	COG0552	protein localization to endoplasmic reticulum
ND448_15840	COG0552	protein localization to endoplasmic reticulum
ND448_15845	COG0742	ribosomal rna small subunit methyltransferase
ND448_15850	COG3776	membrane
ND448_15865	COG3714	YhhN family
ND448_15880	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND448_15890	COG0247	lactate metabolic process
ND448_15900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND448_15910	COG2271	Major facilitator Superfamily
ND448_15915	COG0584	glycerophosphoryl diester phosphodiesterase
ND448_15920	COG0561	phosphatase activity
ND448_15925	COG2267	carboxylic ester hydrolase activity
ND448_15930	COG1280	lysine exporter protein (LysE YggA)
ND448_15935	COG0514	ATP-dependent DNA helicase (RecQ)
ND448_15940	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND448_15945	COG2050	protein possibly involved in aromatic compounds catabolism
ND448_15965	COG5564	TIM-barrel signal transduction protein
ND448_15970	COG5441	Belongs to the UPF0261 family
ND448_15980	COG0210	DNA helicase
ND448_15985	COG1011	Hydrolase
ND448_15990	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND448_15995	COG3159	Protein conserved in bacteria
ND448_16000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND448_16005	COG5567	small periplasmic lipoprotein
ND448_16015	COG3072	Adenylate cyclase
ND448_16020	COG0181	hydroxymethylbilane synthase activity
ND448_16025	COG1587	Uroporphyrinogen-III synthase
ND448_16030	COG2959	enzyme of heme biosynthesis
ND448_16035	COG3071	HemY protein
ND448_16085	COG2244	polysaccharide biosynthetic process
ND448_16090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND448_16095	COG0456	acetyltransferase
ND448_16100	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND448_16105	COG1088	dTDP-glucose 4,6-dehydratase activity
ND448_16110	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND448_16115	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND448_16120	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND448_16125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND448_16130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND448_16135	COG3118	belongs to the thioredoxin family
ND448_16145	COG0248	Ppx GppA phosphatase
ND448_16155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND448_16170	COG3397	chitin binding
ND448_16180	COG0129	dihydroxy-acid dehydratase activity
ND448_16190	COG3978	acetolactate synthase activity
ND448_16210	COG3085	chromosome segregation
ND448_16215	COG0583	DNA-binding transcription factor activity
ND448_16290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND448_16300	COG0678	peroxiredoxin activity
ND448_16300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND448_16305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND448_16340	COG1629	transport
ND448_16345	COG0165	Argininosuccinate lyase
ND448_16350	COG0137	argininosuccinate synthase activity
ND448_16355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND448_16400	COG0527	aspartate kinase activity
ND448_16400	COG0460	homoserine dehydrogenase
ND448_16405	COG0626	cystathionine gamma-synthase activity
ND448_16410	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND448_16420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND448_16425	COG1609	Transcriptional regulator
ND448_16430	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND448_16435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND448_16440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND448_16445	COG1575	Belongs to the MenA family. Type 1 subfamily
ND448_16450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND448_16455	COG3074	FtsZ-dependent cytokinesis
ND448_16460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND448_16465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND448_16470	COG1494	fructose-1,6-bisphosphatase
ND448_16475	COG2814	Major facilitator Superfamily
ND448_16485	COG3152	Membrane
ND448_16500	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND448_16510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND448_16515	COG3678	ATP-independent chaperone mediated protein folding
ND448_16520	COG0745	RESPONSE REGULATOR receiver
ND448_16525	COG2205	protein histidine kinase activity
ND448_16530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND448_16535	COG1045	serine acetyltransferase
ND448_16540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND448_16545	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND448_16550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND448_16555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND448_16560	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND448_16565	COG4942	peptidase
ND448_16570	COG2861	carbohydrate metabolic process
ND448_16585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND448_16590	COG0859	PFAM glycosyl transferase family 9
ND448_16595	COG0859	PFAM glycosyl transferase family 9
ND448_16600	COG1519	Transferase
ND448_16620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND448_16625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND448_16630	COG2003	Belongs to the UPF0758 family
ND448_16635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND448_16640	COG0756	dUTP diphosphatase activity
ND448_16645	COG1309	transcriptional regulator
ND448_16650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND448_16655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND448_16660	COG1561	YicC-like family, N-terminal region
ND448_16675	COG5001	Diguanylate cyclase
ND448_16680	COG1024	Enoyl-CoA hydratase
ND448_16685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND448_16695	COG2860	membrane
ND448_16700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND448_16710	COG1758	RNA polymerase activity
ND448_16715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND448_16720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND448_16725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND448_16730	COG0786	glutamate:sodium symporter activity
ND448_16735	COG2233	PERMEase
ND448_16740	COG2982	Protein involved in outer membrane biogenesis
ND448_16745	COG0456	acetyltransferase
ND448_16760	COG1011	Hydrolase
ND448_16775	COG3852	Histidine kinase
ND448_16785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND448_16795	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND448_16800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND448_16800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND448_16805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND448_16810	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND448_16815	COG3084	Protein conserved in bacteria
ND448_16825	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND448_16850	COG2186	Transcriptional regulator
ND448_16855	COG1609	Transcriptional regulator
ND448_16860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND448_16870	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND448_16875	COG1129	ABC transporter
ND448_16880	COG1869	D-ribose catabolic process
ND448_16885	COG3158	transport of potassium into the cell
ND448_16890	COG0714	Associated with various cellular activities
ND448_16895	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND448_16905	COG2502	aspartate--ammonia ligase
ND448_16910	COG1522	sequence-specific DNA binding
ND448_16915	COG0716	FMN binding
ND448_16920	COG0445	tRNA wobble uridine modification
ND448_16925	COG0357	Ribosomal RNA small subunit methyltransferase G
ND448_16930	COG3312	ion transport
ND448_16935	COG0356	it plays a direct role in the translocation of protons across the membrane
ND448_16945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND448_16955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND448_16960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND448_16970	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND448_16985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND448_16990	COG0573	inorganic phosphate transmembrane transporter activity
ND448_16995	COG0581	inorganic phosphate transmembrane transporter activity
ND448_17005	COG0704	Plays a role in the regulation of phosphate uptake
ND448_17010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND448_17015	COG0765	amino acid transport
ND448_17020	COG0765	amino acid transport
ND448_17025	COG2252	PERMEase
ND448_17030	COG0840	transmembrane signaling receptor activity
ND448_17040	COG3121	Chaperone
ND448_17055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND448_17060	COG0706	membrane insertase activity
ND448_17070	COG0594	ribonuclease P activity
ND448_17075	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ND448_17110	COG1454	alcohol dehydrogenase
ND448_17215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND448_17230	COG0741	lytic transglycosylase activity
ND448_17390	COG2944	sequence-specific DNA binding
ND448_17460	COG1192	Involved in chromosome partitioning