locus-tag	class	description
ND012_00010	COG0592	DNA-directed DNA polymerase activity
ND012_00020	COG0187	DNA topoisomerase II activity
ND012_00025	COG0561	phosphatase activity
ND012_00030	COG0823	Involved in the tonB-independent uptake of proteins
ND012_00035	COG5645	(Lipo)protein
ND012_00050	COG0569	domain protein
ND012_00050	COG2985	domain, Protein
ND012_00055	COG3977	Valine--pyruvate aminotransferase
ND012_00060	COG2885	chlorophyll binding
ND012_00080	COG2818	Glycosylase
ND012_00135	COG2213	PTS system mannitol-specific
ND012_00135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND012_00145	COG3722	fumarate hydratase activity
ND012_00155	COG2258	MOSC domain
ND012_00160	COG0840	transmembrane signaling receptor activity
ND012_00165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND012_00180	COG0437	4 iron, 4 sulfur cluster binding
ND012_00185	COG2864	formate dehydrogenase
ND012_00195	COG1921	L-seryl-tRNASec selenium transferase activity
ND012_00200	COG3276	selenocysteine insertion sequence binding
ND012_00205	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND012_00215	COG3274	enterobacterial common antigen metabolic process
ND012_00225	COG0582	viral genome integration into host DNA
ND012_00255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND012_00260	COG2986	histidine ammonia-lyase
ND012_00280	COG2194	sulfuric ester hydrolase activity
ND012_00285	COG2197	response regulator
ND012_00290	COG3851	Histidine kinase
ND012_00295	COG2271	Major facilitator Superfamily
ND012_00305	COG0747	negative chemotaxis
ND012_00310	COG0601	transmembrane transport
ND012_00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND012_00320	COG0444	Belongs to the ABC transporter superfamily
ND012_00325	COG4608	Belongs to the ABC transporter superfamily
ND012_00330	COG2194	sulfuric ester hydrolase activity
ND012_00355	COG1215	transferase activity, transferring glycosyl groups
ND012_00360	COG1215	transferase activity, transferring glycosyl groups
ND012_00365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND012_00370	COG0457	Tetratricopeptide repeat
ND012_00370	COG3118	belongs to the thioredoxin family
ND012_00375	COG2200	EAL domain
ND012_00375	COG2199	diguanylate cyclase activity
ND012_00380	COG1301	dicarboxylic acid transport
ND012_00385	COG0612	Peptidase, M16
ND012_00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND012_00395	COG1942	4-Oxalocrotonate Tautomerase
ND012_00400	COG2200	EAL domain
ND012_00405	COG2134	cdp-diacylglycerol pyrophosphatase
ND012_00410	COG1295	ribonuclease BN
ND012_00420	COG1301	dicarboxylic acid transport
ND012_00425	COG0626	cystathionine gamma-synthase activity
ND012_00435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND012_00440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND012_00445	COG0339	signal peptide processing
ND012_00450	COG0742	ribosomal rna small subunit methyltransferase
ND012_00460	COG0589	response to stress
ND012_00470	COG0306	phosphate transporter
ND012_00475	COG2081	HI0933 family
ND012_00555	COG1247	-acetyltransferase
ND012_00560	COG1741	Belongs to the pirin family
ND012_00565	COG1609	Transcriptional regulator
ND012_00570	COG2610	gluconate transmembrane transporter activity
ND012_00575	COG3265	gluconokinase activity
ND012_00580	COG2095	MarC family integral membrane protein
ND012_00585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND012_00590	COG3275	phosphorelay sensor kinase activity
ND012_00595	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND012_00600	COG1523	belongs to the glycosyl hydrolase 13 family
ND012_00605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND012_00610	COG0297	glycogen (starch) synthase activity
ND012_00615	COG0058	SHG alpha-glucan phosphorylase activity
ND012_00620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND012_00625	COG1349	DNA-binding transcription factor activity
ND012_00630	COG0705	Rhomboid family
ND012_00640	COG2909	trisaccharide binding
ND012_00645	COG0058	SHG alpha-glucan phosphorylase activity
ND012_00650	COG1640	4-alpha-glucanotransferase
ND012_00660	COG1040	competence protein
ND012_00665	COG0596	Alpha beta hydrolase
ND012_00685	COG1918	ferrous iron import across plasma membrane
ND012_00690	COG2183	response to ionizing radiation
ND012_00720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND012_00735	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND012_00745	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND012_00750	COG1011	Hydrolase
ND012_00760	COG0494	nUDIX hydrolase
ND012_00765	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND012_00790	COG4796	Type ii and iii secretion system protein
ND012_00795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND012_00815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND012_00825	COG0180	Tryptophanyl-tRNA synthetase
ND012_00845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND012_00850	COG0402	S-adenosylhomocysteine deaminase activity
ND012_00855	COG0738	Major facilitator superfamily
ND012_00870	COG1609	Transcriptional regulator
ND012_00875	COG1486	melibiose metabolic process
ND012_00880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND012_00895	COG1289	transmembrane transporter activity
ND012_00900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND012_00905	COG1765	OsmC-like protein
ND012_00930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND012_00935	COG3954	Phosphoribulokinase
ND012_00945	COG0429	hydrolase of the alpha beta-hydrolase fold
ND012_00955	COG0859	PFAM glycosyl transferase family 9
ND012_00960	COG1216	Glycosyl transferase, family 2
ND012_00965	COG0488	(ABC) transporter
ND012_00970	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND012_00980	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND012_00985	COG1047	Peptidyl-prolyl cis-trans
ND012_00995	COG0545	Peptidyl-prolyl cis-trans isomerase
ND012_01000	COG2964	Protein conserved in bacteria
ND012_01010	COG2923	Belongs to the DsrF TusC family
ND012_01015	COG2168	tRNA wobble position uridine thiolation
ND012_01020	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND012_01025	COG0049	tRNA binding
ND012_01035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND012_01050	COG0051	transcription antitermination factor activity, RNA binding
ND012_01055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND012_01065	COG0089	rRNA binding
ND012_01070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND012_01075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND012_01080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND012_01090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND012_01095	COG0255	Belongs to the universal ribosomal protein uL29 family
ND012_01100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND012_01105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND012_01115	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND012_01140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND012_01145	COG1841	ribosomal large subunit assembly
ND012_01150	COG0200	Binds to the 23S rRNA
ND012_01155	COG0201	protein transport
ND012_01160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND012_01165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND012_01175	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND012_01185	COG0203	ribosomal protein L17
ND012_01190	COG0789	Transcriptional regulator
ND012_01195	COG3036	rescue of stalled ribosome
ND012_01200	COG1970	mechanosensitive ion channel activity
ND012_01210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND012_01210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND012_01215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND012_01220	COG0242	peptide deformylase activity
ND012_01225	COG0758	DNA mediated transformation
ND012_01230	COG2922	Belongs to the Smg family
ND012_01235	COG0551	DNA topoisomerase type I activity
ND012_01240	COG0009	L-threonylcarbamoyladenylate synthase
ND012_01250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND012_01275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND012_01280	COG3162	membrane
ND012_01285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND012_01290	COG1301	dicarboxylic acid transport
ND012_01295	COG2391	methyltransferase activity
ND012_01300	COG0425	Belongs to the sulfur carrier protein TusA family
ND012_01305	COG1086	Polysaccharide biosynthesis protein
ND012_01310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND012_01315	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND012_01320	COG2089	acid synthase
ND012_01340	COG1083	cytidylyl-transferase
ND012_01340	COG2755	lipolytic protein G-D-S-L family
ND012_01345	COG1028	Short-chain dehydrogenase reductase Sdr
ND012_01365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND012_01365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND012_01370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ND012_01390	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND012_01410	COG1309	transcriptional regulator
ND012_01415	COG4232	protein-disulfide reductase activity
ND012_01425	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND012_01455	COG1509	lysine 2,3-aminomutase activity
ND012_01465	COG3397	chitin binding
ND012_01485	COG3188	usher protein
ND012_01505	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND012_01510	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND012_01515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND012_01520	COG1053	succinate dehydrogenase
ND012_01525	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND012_01530	COG1511	domain protein
ND012_01530	COG3264	Mechanosensitive ion channel
ND012_01535	COG0688	phosphatidylethanolamine metabolic process
ND012_01540	COG1162	GTPase activity
ND012_01545	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND012_01565	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND012_01570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND012_01570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND012_01575	COG0802	atpase or kinase
ND012_01580	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND012_01590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND012_01600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND012_01605	COG0330	HflC and HflK could
ND012_01610	COG0330	HflC and HflK could
ND012_01615	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND012_01620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND012_01625	COG1959	2 iron, 2 sulfur cluster binding
ND012_01630	COG0557	exoribonuclease II activity
ND012_01635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND012_01655	COG3121	Chaperone
ND012_01660	COG3188	usher protein
ND012_01680	COG1073	alpha beta
ND012_01690	COG0360	Binds together with S18 to 16S ribosomal RNA
ND012_01695	COG2965	DNA replication, synthesis of RNA primer
ND012_01700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND012_01705	COG0359	binds to the 23S rRNA
ND012_01710	COG3061	Opacity-associated protein A
ND012_01715	COG0545	Peptidyl-prolyl cis-trans isomerase
ND012_01725	COG0737	Belongs to the 5'-nucleotidase family
ND012_01730	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND012_01735	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND012_01745	COG1253	flavin adenine dinucleotide binding
ND012_01750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND012_01755	COG0729	surface antigen
ND012_01760	COG2911	Protein conserved in bacteria
ND012_01765	COG2105	PFAM AIG2 family protein
ND012_01770	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND012_01780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND012_01795	COG3423	Transcriptional regulator
ND012_01810	COG0142	geranyltranstransferase activity
ND012_01825	COG0697	spore germination
ND012_01830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND012_01835	COG0642	Histidine kinase
ND012_01840	COG0745	RESPONSE REGULATOR receiver
ND012_01845	COG2027	D-alanyl-D-alanine carboxypeptidase
ND012_01855	COG1534	Rna-binding protein
ND012_01860	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND012_01870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND012_01875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND012_01880	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND012_01900	COG0195	Participates in both transcription termination and antitermination
ND012_01910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND012_01925	COG1185	polyribonucleotide nucleotidyltransferase activity
ND012_01935	COG0513	Belongs to the DEAD box helicase family
ND012_01940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND012_01945	COG0814	amino acid
ND012_01955	COG0826	peptidase U32
ND012_01960	COG0826	peptidase U32
ND012_01965	COG3154	lipid carrier protein
ND012_01970	COG3153	acetyltransferase
ND012_01975	COG2827	Endonuclease containing a URI domain
ND012_01980	COG0531	amino acid
ND012_01985	COG1982	Orn Lys Arg decarboxylase major
ND012_01995	COG3787	Belongs to the UPF0306 family
ND012_02000	COG0702	epimerase
ND012_02005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND012_02010	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND012_02015	COG3454	Phosphonate metabolism
ND012_02020	COG4778	phosphonate C-P lyase system protein PhnL
ND012_02025	COG4107	phosphonate C-P lyase system protein PhnK
ND012_02030	COG3627	carbon phosphorus lyase activity
ND012_02035	COG3626	phosphonate metabolism
ND012_02040	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND012_02045	COG3624	Phosphonate C-P lyase system protein PhnG
ND012_02065	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND012_02080	COG2927	DNA polymerase III (CHI subunit)
ND012_02085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND012_02090	COG0795	lipopolysaccharide-transporting ATPase activity
ND012_02095	COG0795	lipopolysaccharide-transporting ATPase activity
ND012_02110	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ND012_02120	COG0732	type I restriction modification DNA specificity domain
ND012_02145	COG3077	Addiction module antitoxin, RelB DinJ family
ND012_02235	COG5492	domain, Protein
ND012_02255	COG3119	arylsulfatase activity
ND012_02260	COG1349	DNA-binding transcription factor activity
ND012_02270	COG2222	sugar isomerase
ND012_02275	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND012_02280	COG3715	PTS system
ND012_02285	COG3716	PTS system mannose fructose sorbose family IID component
ND012_02295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND012_02305	COG1028	Short-chain dehydrogenase reductase Sdr
ND012_02315	COG0641	radical SAM
ND012_02320	COG3119	arylsulfatase activity
ND012_02345	COG0859	PFAM glycosyl transferase family 9
ND012_02360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND012_02365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND012_02375	COG2376	Dihydroxyacetone kinase
ND012_02380	COG1461	Dihydroxyacetone kinase
ND012_02385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND012_02385	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND012_02385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND012_02425	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND012_02440	COG2823	Periplasmic or secreted lipoprotein
ND012_02450	COG4667	esterase of the alpha-beta hydrolase superfamily
ND012_02455	COG0084	hydrolase, TatD family'
ND012_02460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND012_02475	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND012_02485	COG3726	membrane protein affecting hemolysin expression
ND012_02490	COG0560	Phosphoserine phosphatase
ND012_02505	COG0488	(ABC) transporter
ND012_02525	COG0741	lytic transglycosylase activity
ND012_02530	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND012_02535	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND012_02540	COG0406	alpha-ribazole phosphatase activity
ND012_02545	COG3708	Transcriptional regulator
ND012_02545	COG2207	Transcriptional regulator
ND012_02550	COG3045	CreA protein
ND012_02555	COG0745	RESPONSE REGULATOR receiver
ND012_02590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND012_02595	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND012_02600	COG0477	Major facilitator Superfamily
ND012_02610	COG1584	GPR1 FUN34 yaaH family protein
ND012_02615	COG0443	Heat shock 70 kDa protein
ND012_02625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND012_02630	COG0583	DNA-binding transcription factor activity
ND012_02640	COG0196	riboflavin kinase activity
ND012_02650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND012_02655	COG1047	Peptidyl-prolyl cis-trans
ND012_02660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND012_02675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND012_02685	COG2966	Psort location CytoplasmicMembrane, score
ND012_02710	COG2967	ApaG domain
ND012_02715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND012_02720	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND012_02730	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND012_02740	COG0564	pseudouridine synthase activity
ND012_02745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND012_02750	COG0417	DNA replication proofreading
ND012_02755	COG0586	Pfam SNARE associated Golgi protein
ND012_02765	COG1178	ABC-type Fe3 transport system permease component
ND012_02770	COG4143	(ABC) transporter
ND012_02785	COG2814	Major facilitator Superfamily
ND012_02795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND012_02800	COG0473	3-isopropylmalate dehydrogenase activity
ND012_02815	COG1022	Amp-dependent synthetase and ligase
ND012_02820	COG0028	Belongs to the TPP enzyme family
ND012_02840	COG0675	Transposase, IS605 OrfB family
ND012_02855	COG0275	rRNA processing
ND012_02860	COG3116	cell division
ND012_02865	COG0768	penicillin binding
ND012_02870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND012_02875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND012_02890	COG0772	Belongs to the SEDS family
ND012_02895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND012_02900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND012_02910	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND012_02915	COG0849	cell division
ND012_02920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND012_02945	COG0494	nUDIX hydrolase
ND012_02965	COG0516	GMP reductase activity
ND012_02970	COG1459	type II secretion system
ND012_02975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND012_02980	COG4969	Belongs to the N-Me-Phe pilin family
ND012_02995	COG3725	Membrane protein required for beta-lactamase induction
ND012_03000	COG1113	amino acid transport
ND012_03005	COG2186	Transcriptional regulator
ND012_03010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND012_03015	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND012_03020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND012_03030	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND012_03035	COG3112	Uncharacterised protein family (UPF0231)
ND012_03050	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND012_03060	COG2132	Multicopper oxidase
ND012_03070	COG0288	reversible hydration of carbon dioxide
ND012_03075	COG1131	(ABC) transporter
ND012_03080	COG0842	Transport permease protein
ND012_03085	COG0726	polysaccharide deacetylase
ND012_03090	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND012_03095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND012_03100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND012_03105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND012_03110	COG0617	tRNA 3'-terminal CCA addition
ND012_03125	COG1489	DNA binding
ND012_03130	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND012_03135	COG1643	Atp-dependent helicase
ND012_03140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND012_03145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND012_03155	COG0316	Belongs to the HesB IscA family
ND012_03160	COG2860	membrane
ND012_03170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND012_03175	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND012_03180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND012_03190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND012_03195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND012_03200	COG3956	TIGRFAM MazG family protein
ND012_03205	COG0504	CTP synthase activity
ND012_03215	COG0602	queuosine metabolic process
ND012_03220	COG0720	synthase
ND012_03225	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND012_03235	COG0175	sulfate reduction
ND012_03250	COG2234	aminopeptidase activity
ND012_03255	COG1648	precorrin-2 dehydrogenase activity
ND012_03255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND012_03260	COG0175	sulfate reduction
ND012_03265	COG2895	sulfate adenylyltransferase (ATP) activity
ND012_03270	COG0529	Catalyzes the synthesis of activated sulfate
ND012_03280	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND012_03290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND012_03295	COG0585	pseudouridine synthase activity
ND012_03300	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND012_03310	COG4942	peptidase
ND012_03310	COG1388	LysM domain
ND012_03315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND012_03320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND012_03390	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND012_03390	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND012_03405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND012_03410	COG2137	regulation of response to DNA damage stimulus
ND012_03415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND012_03420	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND012_03450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND012_03455	COG1238	metal cluster binding
ND012_03460	COG2918	glutathione biosynthetic process
ND012_03465	COG1854	S-ribosylhomocysteine lyase activity
ND012_03470	COG4536	flavin adenine dinucleotide binding
ND012_03475	COG4137	Cytochrome C assembly protein
ND012_03480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND012_03490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND012_03495	COG0336	Belongs to the RNA methyltransferase TrmD family
ND012_03500	COG0335	large ribosomal subunit rRNA binding
ND012_03505	COG3137	Salt-induced outer membrane protein
ND012_03510	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND012_03515	COG3279	Response regulator of the LytR AlgR family
ND012_03520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND012_03525	COG1605	Chorismate mutase
ND012_03525	COG0287	Prephenate dehydrogenase
ND012_03530	COG1605	Chorismate mutase
ND012_03530	COG0077	Prephenate dehydratase
ND012_03540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND012_03545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND012_03550	COG0564	pseudouridine synthase activity
ND012_03555	COG1496	oxidoreductase activity
ND012_03560	COG0542	response to heat
ND012_03595	COG3021	interspecies interaction between organisms
ND012_03600	COG1388	LysM domain
ND012_03600	COG0741	lytic transglycosylase activity
ND012_03610	COG2226	methyltransferase
ND012_03620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND012_03630	COG1960	acyl-CoA dehydrogenase activity
ND012_03635	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND012_03640	COG0121	glutamine amidotransferase
ND012_03645	COG3034	peptidoglycan biosynthetic process
ND012_03655	COG1805	sodium ion transport
ND012_03660	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND012_03665	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND012_03670	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND012_03680	COG1477	protein flavinylation
ND012_03685	COG2991	Protein conserved in bacteria
ND012_03695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND012_03700	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND012_03705	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND012_03710	COG1073	alpha beta
ND012_03725	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND012_03760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND012_03780	COG4126	flavin adenine dinucleotide binding
ND012_03790	COG2974	May be involved in recombination
ND012_03795	COG1940	carbohydrate kinase activity
ND012_03800	COG0419	ATPase involved in DNA repair
ND012_03805	COG0420	3'-5' exonuclease activity
ND012_03810	COG0745	RESPONSE REGULATOR receiver
ND012_03815	COG5002	protein histidine kinase activity
ND012_03830	COG1113	amino acid transport
ND012_03835	COG0366	Alpha amylase catalytic
ND012_03840	COG0300	oxidoreductase activity
ND012_03845	COG0450	alkyl hydroperoxide reductase
ND012_03850	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND012_03865	COG1862	Preprotein translocase
ND012_03870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND012_03875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND012_03880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND012_03885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND012_03885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND012_03890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND012_03900	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND012_03905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND012_03910	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND012_03915	COG0142	geranyltranstransferase activity
ND012_03950	COG0693	protein deglycase activity
ND012_03955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND012_03960	COG1666	GTP binding
ND012_03965	COG2814	Major facilitator Superfamily
ND012_03975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND012_03980	COG1845	cytochrome c oxidase, subunit III
ND012_03985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND012_03990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND012_04000	COG2223	nitrite transmembrane transporter activity
ND012_04005	COG3056	Lipoprotein
ND012_04010	COG0271	Belongs to the BolA IbaG family
ND012_04020	COG0740	serine-type endopeptidase activity
ND012_04025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND012_04030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND012_04035	COG0776	regulation of translation
ND012_04040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND012_04045	COG1555	photosystem II stabilization
ND012_04050	COG0824	Thioesterase
ND012_04055	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND012_04060	COG4533	DNA binding
ND012_04075	COG1522	sequence-specific DNA binding
ND012_04080	COG1132	(ABC) transporter
ND012_04085	COG1132	(ABC) transporter
ND012_04090	COG0347	Belongs to the P(II) protein family
ND012_04095	COG0004	ammonium transporteR
ND012_04100	COG1946	Acyl-CoA thioesterase
ND012_04105	COG3695	enzyme binding
ND012_04130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND012_04135	COG0254	rRNA binding
ND012_04140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND012_04145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND012_04150	COG1309	transcriptional regulator
ND012_04155	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND012_04160	COG1196	nuclear chromosome segregation
ND012_04160	COG3264	Mechanosensitive ion channel
ND012_04175	COG2832	Protein of unknown function (DUF454)
ND012_04180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND012_04220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND012_04225	COG0326	Molecular chaperone. Has ATPase activity
ND012_04240	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND012_04245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND012_04250	COG4651	solute:proton antiporter activity
ND012_04250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND012_04255	COG0737	Belongs to the 5'-nucleotidase family
ND012_04260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND012_04265	COG3735	TraB family
ND012_04270	COG2217	Heavy metal translocating P-type atpase
ND012_04275	COG0789	Transcriptional regulator
ND012_04280	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND012_04285	COG0330	HflC and HflK could
ND012_04290	COG3118	belongs to the thioredoxin family
ND012_04295	COG0300	oxidoreductase activity
ND012_04300	COG2755	lipolytic protein G-D-S-L family
ND012_04305	COG4181	ATPase activity
ND012_04310	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND012_04315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND012_04320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND012_04325	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND012_04330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND012_04355	COG3188	usher protein
ND012_04360	COG3121	Chaperone
ND012_04390	COG2501	S4 domain
ND012_04395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND012_04410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND012_04415	COG1393	Belongs to the ArsC family
ND012_04425	COG1022	Amp-dependent synthetase and ligase
ND012_04450	COG3038	cytochrome b561
ND012_04480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND012_04490	COG1215	transferase activity, transferring glycosyl groups
ND012_04510	COG3250	beta-galactosidase activity
ND012_04525	COG1309	transcriptional regulator
ND012_04550	COG2197	response regulator
ND012_04555	COG1278	Cold shock
ND012_04575	COG3706	GGDEF domain
ND012_04585	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND012_04595	COG2921	Belongs to the UPF0250 family
ND012_04600	COG1686	Belongs to the peptidase S11 family
ND012_04605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND012_04610	COG0772	Belongs to the SEDS family
ND012_04615	COG0768	penicillin binding
ND012_04620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND012_04625	COG0799	negative regulation of ribosome biogenesis
ND012_04630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND012_04635	COG1466	dna polymerase III delta subunit
ND012_04640	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND012_04650	COG2888	peptidyl-tyrosine sulfation
ND012_04655	COG1126	abc transporter atp-binding protein
ND012_04660	COG0765	amino acid transport
ND012_04665	COG0765	amino acid transport
ND012_04675	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND012_04680	COG4535	Mg2 and Co2 transporter CorC
ND012_04685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND012_04690	COG1702	phosphate starvation-inducible protein PhoH
ND012_04695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND012_04700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND012_04735	COG0367	asparagine synthase
ND012_04740	COG0647	UMP catabolic process
ND012_04745	COG1846	Transcriptional regulator
ND012_04745	COG1940	carbohydrate kinase activity
ND012_04750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND012_04760	COG2190	(PTS) system
ND012_04760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND012_04760	COG1263	PTS System
ND012_04785	COG0735	belongs to the Fur family
ND012_04795	COG0840	transmembrane signaling receptor activity
ND012_04805	COG0596	Alpha beta hydrolase
ND012_04810	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND012_04815	COG0033	Phosphoglucomutase
ND012_04825	COG0745	RESPONSE REGULATOR receiver
ND012_04830	COG2205	protein histidine kinase activity
ND012_04835	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND012_04840	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND012_04860	COG3272	Protein of unknown function (DUF1722)
ND012_04865	COG0415	Belongs to the DNA photolyase family
ND012_04870	COG5212	phosphodiesterase
ND012_04875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND012_04880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND012_04885	COG1984	allophanate hydrolase subunit 2
ND012_04890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND012_04925	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND012_04930	COG1053	succinate dehydrogenase
ND012_04935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND012_04940	COG0567	Dehydrogenase, E1 component
ND012_04945	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND012_04950	COG0045	succinate-CoA ligase (ADP-forming) activity
ND012_04955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND012_04965	COG1271	oxidase subunit
ND012_04970	COG1294	oxidase, subunit
ND012_04975	COG4890	Cyd operon protein YbgT
ND012_04980	COG3790	cyd operon protein YbgE
ND012_04985	COG0824	Thioesterase
ND012_04990	COG0811	peptide transport
ND012_04995	COG0848	biopolymer transport protein
ND012_05000	COG3064	Membrane
ND012_05000	COG3064	Membrane
ND012_05005	COG0823	Involved in the tonB-independent uptake of proteins
ND012_05010	COG2885	chlorophyll binding
ND012_05015	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND012_05045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND012_05055	COG2205	protein histidine kinase activity
ND012_05055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND012_05065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND012_05070	COG0588	phosphoglycerate mutase activity
ND012_05080	COG2017	converts alpha-aldose to the beta-anomer
ND012_05090	COG1085	galactose-1-phosphate uridylyltransferase
ND012_05095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND012_05110	COG3585	molybdate ion transport
ND012_05110	COG2005	Transcriptional regulator
ND012_05120	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND012_05125	COG4149	molybdate abc transporter
ND012_05135	COG0561	phosphatase activity
ND012_05140	COG2706	6-phosphogluconolactonase activity
ND012_05155	COG0156	8-amino-7-oxononanoate synthase activity
ND012_05160	COG2226	methyltransferase
ND012_05175	COG0556	nucleotide-excision repair
ND012_05180	COG4628	conserved protein (DUF2132)
ND012_05195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND012_05200	COG1120	ATPase activity
ND012_05205	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND012_05210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND012_05220	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND012_05225	COG0314	molybdopterin synthase activity
ND012_05230	COG0670	Belongs to the BI1 family
ND012_05235	COG0842	Transport permease protein
ND012_05240	COG0842	Transport permease protein
ND012_05245	COG1131	(ABC) transporter
ND012_05250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND012_05255	COG1309	transcriptional regulator
ND012_05260	COG0513	Belongs to the DEAD box helicase family
ND012_05265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND012_05275	COG1686	Belongs to the peptidase S11 family
ND012_05280	COG0277	FAD linked oxidase domain protein
ND012_05300	COG2261	transglycosylase associated protein
ND012_05310	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND012_05325	COG4807	Protein conserved in bacteria
ND012_05330	COG2897	thiosulfate sulfurtransferase activity
ND012_05335	COG1732	Glycine betaine
ND012_05340	COG1174	glycine betaine transport
ND012_05345	COG1125	glycine betaine transport
ND012_05350	COG1174	glycine betaine transport
ND012_05355	COG0531	amino acid
ND012_05360	COG1982	Orn Lys Arg decarboxylase major
ND012_05370	COG0697	spore germination
ND012_05385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND012_05390	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND012_05395	COG1126	abc transporter atp-binding protein
ND012_05400	COG0765	amino acid transport
ND012_05405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND012_05425	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND012_05430	COG2239	Acts as a magnesium transporter
ND012_05435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND012_05440	COG0488	(ABC) transporter
ND012_05445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND012_05450	COG0303	'Molybdopterin
ND012_05470	COG0583	DNA-binding transcription factor activity
ND012_05475	COG0477	Major facilitator Superfamily
ND012_05480	COG0302	gtp cyclohydrolase
ND012_05485	COG2311	Membrane
ND012_05510	COG2949	membrane
ND012_05515	COG0281	malic enzyme
ND012_05525	COG0583	DNA-binding transcription factor activity
ND012_05535	COG1346	cytolysis
ND012_05540	COG1380	Effector of murein hydrolase LrgA
ND012_05550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND012_05550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND012_05555	COG0489	protein tyrosine kinase activity
ND012_05560	COG0572	uridine kinase
ND012_05565	COG0717	Belongs to the dCTP deaminase family
ND012_05570	COG2982	Protein involved in outer membrane biogenesis
ND012_05575	COG3069	C4-dicarboxylate transmembrane transporter activity
ND012_05580	COG1253	flavin adenine dinucleotide binding
ND012_05585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND012_05590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND012_05595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND012_05605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND012_05605	COG0140	phosphoribosyl-ATP diphosphatase activity
ND012_05615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND012_05625	COG0131	Imidazoleglycerol-phosphate dehydratase
ND012_05625	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND012_05630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND012_05635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND012_05650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND012_05655	COG0625	glutathione transferase activity
ND012_05670	COG0626	cystathionine gamma-synthase activity
ND012_05680	COG1686	Belongs to the peptidase S11 family
ND012_05685	COG1760	l-serine dehydratase
ND012_05690	COG0814	amino acid
ND012_05695	COG1349	DNA-binding transcription factor activity
ND012_05705	COG0671	phosphoesterase, PA-phosphatase related
ND012_05715	COG2985	domain, Protein
ND012_05715	COG0569	domain protein
ND012_05735	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND012_05740	COG3842	ATPase activity
ND012_05745	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND012_05750	COG1177	transmembrane transport
ND012_05765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND012_05770	COG4160	amino acid transport
ND012_05775	COG4215	(ABC) transporter
ND012_05780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND012_05785	COG1126	abc transporter atp-binding protein
ND012_05795	COG0393	Putative heavy-metal-binding
ND012_05800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND012_05805	COG0702	epimerase
ND012_05810	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND012_05815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND012_05820	COG1151	hydroxylamine reductase activity
ND012_05825	COG2431	L-lysine efflux transmembrane transporter activity
ND012_05830	COG3593	DNA synthesis involved in DNA repair
ND012_05835	COG2990	Protein conserved in bacteria
ND012_05840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND012_05850	COG1278	Cold shock
ND012_05855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND012_05860	COG0542	response to heat
ND012_05865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND012_05875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND012_05885	COG0492	ferredoxin-NADP+ reductase activity
ND012_05890	COG1522	sequence-specific DNA binding
ND012_05895	COG1674	ftsk spoiiie
ND012_05895	COG3107	peptidoglycan biosynthetic process
ND012_05900	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND012_05905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND012_05910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND012_05915	COG2814	Major facilitator Superfamily
ND012_05920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND012_05925	COG1882	Formate acetyltransferase
ND012_05930	COG2116	formate transmembrane transporter activity
ND012_05935	COG1944	ATP diphosphatase activity
ND012_05940	COG0252	asparaginase activity
ND012_05950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND012_05960	COG0539	negative regulation of cytoplasmic translation
ND012_05970	COG2333	competence protein COMEC
ND012_05970	COG0658	competence protein
ND012_05980	COG1663	tetraacyldisaccharide 4'-kinase activity
ND012_05985	COG5383	Protein conserved in bacteria
ND012_05995	COG1278	Cold shock
ND012_06000	COG2835	tetraacyldisaccharide 4'-kinase activity
ND012_06005	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND012_06010	COG3173	Aminoglycoside phosphotransferase
ND012_06015	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND012_06020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND012_06025	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND012_06035	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND012_06040	COG2989	Protein conserved in bacteria
ND012_06045	COG3108	Peptidase M15
ND012_06050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND012_06055	COG1448	Aminotransferase
ND012_06070	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND012_06075	COG0308	aminopeptidase N
ND012_06080	COG0167	dihydroorotate dehydrogenase activity
ND012_06090	COG0633	Ferredoxin
ND012_06090	COG3217	Mosc domain protein beta barrel domain protein
ND012_06095	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND012_06095	COG0116	Belongs to the methyltransferase superfamily
ND012_06100	COG0488	(ABC) transporter
ND012_06105	COG2995	paraquat-inducible protein a
ND012_06110	COG3008	intermembrane lipid transfer
ND012_06110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND012_06115	COG3009	Protein conserved in bacteria
ND012_06120	COG3130	regulation of translation
ND012_06125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND012_06130	COG1067	ATP-dependent peptidase activity
ND012_06135	COG3120	sequence-specific DNA binding
ND012_06145	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND012_06150	COG3070	regulator of competence-specific genes
ND012_06155	COG1289	transmembrane transporter activity
ND012_06160	COG3304	Inner membrane component domain
ND012_06165	COG0210	DNA helicase
ND012_06170	COG1803	Methylglyoxal synthase
ND012_06180	COG1832	CoA-binding protein
ND012_06185	COG3785	DNA binding
ND012_06190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND012_06195	COG1254	Belongs to the acylphosphatase family
ND012_06200	COG2920	part of a sulfur-relay system
ND012_06210	COG0288	reversible hydration of carbon dioxide
ND012_06230	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND012_06235	COG2943	transferase activity, transferring hexosyl groups
ND012_06255	COG1560	Kdo2-lipid A biosynthetic process
ND012_06265	COG0628	permease
ND012_06290	COG0418	dihydroorotase activity
ND012_06295	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND012_06305	COG1530	ribonuclease E activity
ND012_06310	COG0564	pseudouridine synthase activity
ND012_06315	COG0424	maF-like protein
ND012_06320	COG1399	metal-binding, possibly nucleic acid-binding protein
ND012_06325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND012_06335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND012_06340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND012_06350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND012_06355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND012_06360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND012_06365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND012_06370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND012_06375	COG0470	DNA polymerase III
ND012_06380	COG0084	hydrolase, TatD family'
ND012_06385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND012_06385	COG1263	PTS System
ND012_06390	COG0537	adenosine 5'-monophosphoramidase activity
ND012_06395	COG5633	Lipoprotein
ND012_06400	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND012_06415	COG3150	esterase
ND012_06420	COG1252	NADH dehydrogenase
ND012_06425	COG3134	Outer membrane lipoprotein
ND012_06430	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND012_06435	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND012_06445	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND012_06465	COG2850	peptidyl-arginine hydroxylation
ND012_06470	COG2205	protein histidine kinase activity
ND012_06475	COG0745	RESPONSE REGULATOR receiver
ND012_06485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND012_06495	COG0482	sulfurtransferase activity
ND012_06505	COG1187	pseudouridine synthase activity
ND012_06510	COG0538	isocitrate dehydrogenase activity
ND012_06515	COG2771	luxR family
ND012_06520	COG3916	Acyl-homoserine-lactone synthase
ND012_06525	COG2723	6-phospho-beta-galactosidase activity
ND012_06535	COG0339	signal peptide processing
ND012_06545	COG3493	citrate carrier protein
ND012_06550	COG4565	transcriptional regulatory protein
ND012_06555	COG3290	protein histidine kinase activity
ND012_06560	COG0471	metal ion transport
ND012_06600	COG4977	sequence-specific DNA binding
ND012_06605	COG1702	phosphate starvation-inducible protein PhoH
ND012_06610	COG0387	Pfam Sodium calcium exchanger
ND012_06615	COG2375	cellular response to nickel ion
ND012_06620	COG3850	Histidine kinase
ND012_06630	COG1294	oxidase, subunit
ND012_06635	COG1271	oxidase subunit
ND012_06640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND012_06645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND012_06650	COG3138	arginine N-succinyltransferase
ND012_06660	COG3724	N-succinylarginine dihydrolase activity
ND012_06680	COG1228	amidohydrolase
ND012_06690	COG0402	S-adenosylhomocysteine deaminase activity
ND012_06710	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND012_06715	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND012_06720	COG3383	formate dehydrogenase (NAD+) activity
ND012_06725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND012_06730	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND012_06740	COG3260	NADH ubiquinone oxidoreductase 20
ND012_06745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND012_06750	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND012_06750	COG3261	NADH dehydrogenase
ND012_06755	COG0650	Formate hydrogenlyase subunit 4
ND012_06760	COG0651	ATP synthesis coupled electron transport
ND012_06765	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND012_06775	COG0375	protein maturation
ND012_06780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND012_06785	COG0298	carbon dioxide binding
ND012_06790	COG0409	Hydrogenase expression formation protein
ND012_06795	COG0309	Hydrogenase expression formation protein (HypE)
ND012_06830	COG3708	Transcriptional regulator
ND012_06830	COG2207	Transcriptional regulator
ND012_06835	COG0012	GTP binding
ND012_06845	COG0193	aminoacyl-tRNA hydrolase activity
ND012_06855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND012_06865	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND012_06870	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND012_06875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND012_06880	COG2890	protein-(glutamine-N5) methyltransferase activity
ND012_06895	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND012_06900	COG0659	secondary active sulfate transmembrane transporter activity
ND012_06905	COG3706	GGDEF domain
ND012_06930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND012_06940	COG3381	protein complex oligomerization
ND012_06960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND012_06970	COG0673	inositol 2-dehydrogenase activity
ND012_06975	COG0728	peptidoglycan biosynthetic process
ND012_07000	COG3102	Protein conserved in bacteria
ND012_07005	COG3142	Participates in the control of copper homeostasis
ND012_07020	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND012_07025	COG1801	Protein of unknown function DUF72
ND012_07035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND012_07040	COG0494	nUDIX hydrolase
ND012_07050	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND012_07060	COG2255	four-way junction helicase activity
ND012_07065	COG3104	oligopeptide transport
ND012_07070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND012_07075	COG1121	(ABC) transporter
ND012_07080	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND012_07085	COG0739	heme binding
ND012_07090	COG1560	Kdo2-lipid A biosynthetic process
ND012_07095	COG0469	pyruvate kinase activity
ND012_07100	COG1737	Transcriptional regulator
ND012_07105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND012_07110	COG0800	Aldolase
ND012_07120	COG2076	Multidrug Resistance protein
ND012_07125	COG0251	oxidation-reduction process
ND012_07130	COG1199	ATP-dependent helicase activity
ND012_07135	COG1214	PFAM Peptidase M22, glycoprotease
ND012_07140	COG3065	identical protein binding
ND012_07145	COG0318	PFAM AMP-dependent synthetase and ligase
ND012_07150	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND012_07155	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND012_07160	COG2894	cell division
ND012_07165	COG0850	regulation of cytokinetic process
ND012_07170	COG3100	YcgL domain-containing protein
ND012_07175	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND012_07180	COG2983	Belongs to the UPF0260 family
ND012_07200	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND012_07210	COG2719	SpoVR family
ND012_07215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND012_07220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND012_07225	COG2814	Major facilitator Superfamily
ND012_07235	COG2202	Pas domain
ND012_07235	COG2200	EAL domain
ND012_07235	COG2199	diguanylate cyclase activity
ND012_07255	COG2718	Belongs to the UPF0229 family
ND012_07260	COG2766	serine protein kinase
ND012_07270	COG3713	MltA-interacting MipA family protein
ND012_07275	COG2194	sulfuric ester hydrolase activity
ND012_07290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND012_07295	COG3139	Protein of unknown function (DUF1315)
ND012_07300	COG1335	isochorismatase
ND012_07305	COG0252	asparaginase activity
ND012_07310	COG0616	signal peptide processing
ND012_07315	COG0778	Nitroreductase
ND012_07325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND012_07335	COG0494	nUDIX hydrolase
ND012_07340	COG0708	Exodeoxyribonuclease III
ND012_07370	COG0788	formyltetrahydrofolate deformylase activity
ND012_07380	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND012_07385	COG0745	RESPONSE REGULATOR receiver
ND012_07405	COG1454	alcohol dehydrogenase
ND012_07405	COG1012	belongs to the aldehyde dehydrogenase family
ND012_07415	COG2095	MarC family integral membrane protein
ND012_07420	COG4166	transmembrane transport
ND012_07435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND012_07450	COG3099	Belongs to the UPF0263 family
ND012_07455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND012_07475	COG2350	Protein conserved in bacteria
ND012_07490	COG3710	Transcriptional regulator
ND012_07525	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND012_07550	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND012_07555	COG3047	cAMP biosynthetic process
ND012_07570	COG0133	tryptophan synthase activity
ND012_07575	COG0135	phosphoribosylanthranilate isomerase activity
ND012_07575	COG0134	indole-3-glycerol-phosphate synthase activity
ND012_07585	COG0512	Glutamine amidotransferase of anthranilate synthase
ND012_07595	COG0613	PHP domain protein
ND012_07600	COG0009	L-threonylcarbamoyladenylate synthase
ND012_07605	COG1187	pseudouridine synthase activity
ND012_07615	COG1028	Short-chain dehydrogenase reductase Sdr
ND012_07620	COG0616	signal peptide processing
ND012_07635	COG0583	DNA-binding transcription factor activity
ND012_07655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND012_07665	COG0671	phosphoesterase, PA-phosphatase related
ND012_07670	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND012_07675	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND012_07695	COG0023	Translation Initiation Factor
ND012_07705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND012_07710	COG5002	protein histidine kinase activity
ND012_07710	COG3447	MASE1 domain protein
ND012_07710	COG5001	Diguanylate cyclase
ND012_07715	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND012_07720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND012_07730	COG4659	FMN binding
ND012_07740	COG2207	Transcriptional regulator
ND012_07740	COG3708	Transcriptional regulator
ND012_07755	COG4657	Part of a membrane complex involved in electron transport
ND012_07765	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND012_07775	COG0673	inositol 2-dehydrogenase activity
ND012_07780	COG0385	Bile acid
ND012_07785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND012_07790	COG5339	Protein conserved in bacteria
ND012_07795	COG1482	cell wall glycoprotein biosynthetic process
ND012_07800	COG0114	fumarate hydratase activity
ND012_07810	COG1940	carbohydrate kinase activity
ND012_07815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND012_07835	COG1742	UPF0060 membrane protein
ND012_07840	COG4221	oxidoreductase activity
ND012_07845	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND012_07865	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND012_07905	COG1011	Hydrolase
ND012_07915	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND012_07920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND012_07925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND012_07930	COG0589	response to stress
ND012_07960	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND012_07965	COG3623	hexulose-6-phosphate isomerase
ND012_07970	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND012_07975	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND012_07985	COG0531	amino acid
ND012_07995	COG0745	RESPONSE REGULATOR receiver
ND012_08000	COG2205	protein histidine kinase activity
ND012_08015	COG2207	Transcriptional regulator
ND012_08020	COG1881	PFAM PEBP family protein
ND012_08030	COG3591	Belongs to the peptidase S1B family
ND012_08035	COG1643	Atp-dependent helicase
ND012_08040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND012_08045	COG3784	Protein of unknown function (DUF1318)
ND012_08060	COG2911	Protein conserved in bacteria
ND012_08065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND012_08070	COG3187	Heat shock protein
ND012_08075	COG3042	response to heat
ND012_08090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND012_08090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND012_08090	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND012_08090	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND012_08105	COG4166	transmembrane transport
ND012_08110	COG2866	Carboxypeptidase
ND012_08115	COG4948	Mandelate Racemase Muconate Lactonizing
ND012_08120	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND012_08130	COG5642	Protein of unknown function (DUF2384)
ND012_08135	COG5654	RES domain protein
ND012_08140	COG3768	UPF0283 membrane protein
ND012_08145	COG3106	COG3106 Predicted ATPase
ND012_08155	COG1983	PspC domain protein
ND012_08165	COG1842	Phage shock protein A
ND012_08170	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND012_08185	COG4166	transmembrane transport
ND012_08195	COG4171	peptide transport system, permease
ND012_08200	COG4172	Belongs to the ABC transporter superfamily
ND012_08205	COG4172	Belongs to the ABC transporter superfamily
ND012_08215	COG3104	oligopeptide transport
ND012_08225	COG0484	heat shock protein binding
ND012_08270	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND012_08275	COG3133	Outer membrane lipoprotein
ND012_08280	COG1846	Transcriptional regulator
ND012_08290	COG4989	oxidoreductase activity
ND012_08295	COG3313	Fe-S protein
ND012_08300	COG2194	sulfuric ester hydrolase activity
ND012_08305	COG1309	transcriptional regulator
ND012_08310	COG1902	pentaerythritol trinitrate reductase activity
ND012_08325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND012_08330	COG0791	NLP P60 protein
ND012_08335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND012_08345	COG1609	Transcriptional regulator
ND012_08350	COG0583	DNA-binding transcription factor activity
ND012_08355	COG2814	Major facilitator Superfamily
ND012_08360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND012_08365	COG0307	riboflavin synthase, alpha
ND012_08400	COG1376	ErfK ybiS ycfS ynhG family protein
ND012_08400	COG1388	LysM domain
ND012_08405	COG2166	iron-sulfur cluster assembly
ND012_08415	COG0719	Fe-S assembly protein
ND012_08420	COG0396	ATPase activity
ND012_08425	COG0719	Fe-S assembly protein
ND012_08430	COG0316	Belongs to the HesB IscA family
ND012_08435	COG2050	protein possibly involved in aromatic compounds catabolism
ND012_08440	COG0247	lactate metabolic process
ND012_08440	COG0277	FAD linked oxidase domain protein
ND012_08445	COG0628	permease
ND012_08455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND012_08455	COG0574	Belongs to the PEP-utilizing enzyme family
ND012_08460	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND012_08465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND012_08475	COG4771	TonB-dependent receptor
ND012_08480	COG3720	iron ion transport
ND012_08485	COG4558	Periplasmic binding protein
ND012_08490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND012_08495	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND012_08505	COG0095	Lipoate-protein ligase
ND012_08510	COG0791	NLP P60 protein
ND012_08515	COG2076	Multidrug Resistance protein
ND012_08520	COG2076	Multidrug Resistance protein
ND012_08525	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND012_08540	COG0463	Glycosyl transferase, family 2
ND012_08545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND012_08555	COG4139	cobalamin transport
ND012_08560	COG4974	Belongs to the 'phage' integrase family
ND012_08600	COG0776	regulation of translation
ND012_08670	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND012_08675	COG1121	(ABC) transporter
ND012_08680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND012_08685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND012_08690	COG3001	Fructosamine kinase
ND012_08700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND012_08705	COG1988	membrane-bound metal-dependent
ND012_08710	COG1823	symporter activity
ND012_08715	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND012_08725	COG2814	Major facilitator Superfamily
ND012_08735	COG0501	Belongs to the peptidase M48B family
ND012_08740	COG0793	Belongs to the peptidase S41A family
ND012_08750	COG1956	GAF domain-containing protein
ND012_08755	COG2995	paraquat-inducible protein a
ND012_08760	COG3008	intermembrane lipid transfer
ND012_08765	COG2203	Gaf domain
ND012_08765	COG4251	negative regulation of phosphorylation
ND012_08765	COG5001	Diguanylate cyclase
ND012_08765	COG3706	GGDEF domain
ND012_08845	COG1276	copper resistance
ND012_08850	COG2372	response to copper ion
ND012_08855	COG1528	Iron-storage protein
ND012_08870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND012_08875	COG1770	oligopeptidase
ND012_08885	COG3097	Belongs to the UPF0267 family
ND012_08890	COG3141	response to X-ray
ND012_08895	COG0513	Belongs to the DEAD box helicase family
ND012_08915	COG0494	nUDIX hydrolase
ND012_08920	COG1760	l-serine dehydratase
ND012_08925	COG1253	flavin adenine dinucleotide binding
ND012_08930	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND012_08930	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND012_08935	COG3715	PTS system
ND012_08940	COG3716	PTS system mannose fructose sorbose family IID component
ND012_08945	COG4811	Protein of unknown function (DUF986)
ND012_08950	COG1971	Probably functions as a manganese efflux pump
ND012_08970	COG1960	acyl-CoA dehydrogenase activity
ND012_08980	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND012_09010	COG2226	methyltransferase
ND012_09015	COG0768	penicillin binding
ND012_09020	COG1496	oxidoreductase activity
ND012_09040	COG1113	amino acid transport
ND012_09075	COG2207	Transcriptional regulator
ND012_09095	COG1132	(ABC) transporter
ND012_09105	COG5001	Diguanylate cyclase
ND012_09105	COG3706	GGDEF domain
ND012_09105	COG2203	Gaf domain
ND012_09105	COG4251	negative regulation of phosphorylation
ND012_09125	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND012_09145	COG1278	Cold shock
ND012_09150	COG1278	Cold shock
ND012_09165	COG1917	Cupin 2, conserved barrel domain protein
ND012_09165	COG2169	Transcriptional regulator
ND012_09170	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND012_09175	COG2723	6-phospho-beta-galactosidase activity
ND012_09180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND012_09185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND012_09190	COG1187	pseudouridine synthase activity
ND012_09200	COG3122	Protein conserved in bacteria
ND012_09205	COG1757	Na H antiporter
ND012_09220	COG2235	arginine
ND012_09235	COG0076	glutamate decarboxylase activity
ND012_09240	COG0531	amino acid
ND012_09275	COG2153	protein acetylation
ND012_09280	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND012_09330	COG2205	protein histidine kinase activity
ND012_09330	COG3437	response regulator, receiver
ND012_09330	COG3850	Histidine kinase
ND012_09330	COG4999	Histidine kinase
ND012_09385	COG0740	serine-type endopeptidase activity
ND012_09430	COG0840	transmembrane signaling receptor activity
ND012_09435	COG2801	Transposase and inactivated derivatives
ND012_09555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND012_09560	COG0322	excinuclease ABC activity
ND012_09565	COG2197	response regulator
ND012_09590	COG1113	amino acid transport
ND012_09600	COG0531	amino acid
ND012_09605	COG3710	Transcriptional regulator
ND012_09610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND012_09615	COG0506	proline dehydrogenase activity
ND012_09615	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND012_09615	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND012_09620	COG1126	abc transporter atp-binding protein
ND012_09625	COG0765	amino acid transport
ND012_09630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND012_09635	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND012_09645	COG1191	sigma factor activity
ND012_09685	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND012_09690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND012_09705	COG1677	Flagellar hook-basal body complex protein FliE
ND012_09715	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND012_09725	COG1157	protein secretion by the type III secretion system
ND012_09740	COG1580	Controls the rotational direction of flagella during chemotaxis
ND012_09820	COG1558	bacterial-type flagellum-dependent cell motility
ND012_09825	COG1815	bacterial-type flagellum-dependent cell motility
ND012_09835	COG2747	anti-sigma28 factor FlgM
ND012_09840	COG3418	PFAM FlgN family protein
ND012_09850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND012_09855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND012_09860	COG4935	Belongs to the peptidase S8 family
ND012_09860	COG1404	Belongs to the peptidase S8 family
ND012_09865	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND012_09870	COG0745	RESPONSE REGULATOR receiver
ND012_09880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND012_09885	COG0840	transmembrane signaling receptor activity
ND012_09890	COG0840	transmembrane signaling receptor activity
ND012_09895	COG0835	chemotaxis
ND012_09900	COG0643	Histidine kinase
ND012_09900	COG2198	Histidine kinase
ND012_09905	COG1360	Flagellar Motor Protein
ND012_09925	COG0589	response to stress
ND012_09930	COG1285	pathogenesis
ND012_09935	COG0840	transmembrane signaling receptor activity
ND012_09950	COG1609	Transcriptional regulator
ND012_09960	COG1028	Short-chain dehydrogenase reductase Sdr
ND012_09960	COG3321	synthase
ND012_09960	COG0604	alcohol dehydrogenase
ND012_10010	COG0471	metal ion transport
ND012_10025	COG3051	citrate lyase alpha subunit
ND012_10030	COG2301	Belongs to the HpcH HpaI aldolase family
ND012_10035	COG3052	prosthetic group binding
ND012_10040	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND012_10045	COG3290	protein histidine kinase activity
ND012_10050	COG4565	transcriptional regulatory protein
ND012_10065	COG2271	Major facilitator Superfamily
ND012_10070	COG1840	ABC-type Fe3 transport system, periplasmic component
ND012_10080	COG3842	ATPase activity
ND012_10105	COG1289	transmembrane transporter activity
ND012_10115	COG2925	Exonuclease
ND012_10120	COG0531	amino acid
ND012_10125	COG4771	TonB-dependent receptor
ND012_10135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND012_10145	COG0833	amino acid
ND012_10150	COG0583	DNA-binding transcription factor activity
ND012_10160	COG2855	membrane
ND012_10165	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND012_10170	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND012_10170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND012_10170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND012_10175	COG1105	Belongs to the carbohydrate kinase PfkB family
ND012_10190	COG3005	denitrification pathway
ND012_10195	COG0243	molybdopterin cofactor binding
ND012_10210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND012_10220	COG0246	Mannitol dehydrogenase
ND012_10230	COG0523	cobalamin synthesis protein
ND012_10235	COG0671	phosphoesterase, PA-phosphatase related
ND012_10240	COG0791	NLP P60 protein
ND012_10245	COG2200	EAL domain
ND012_10250	COG4166	transmembrane transport
ND012_10255	COG4174	ABC transporter (Permease)
ND012_10260	COG4239	(ABC) transporter, permease
ND012_10265	COG4172	Belongs to the ABC transporter superfamily
ND012_10275	COG2814	Major facilitator Superfamily
ND012_10280	COG1187	pseudouridine synthase activity
ND012_10285	COG1061	Type III restriction enzyme res subunit
ND012_10300	COG3082	Protein of unknown function (DUF1414)
ND012_10305	COG3083	sulfuric ester hydrolase activity
ND012_10320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ND012_10345	COG3299	homolog of phage Mu protein gp47
ND012_10390	COG4386	tail sheath protein
ND012_10430	COG0616	signal peptide processing
ND012_10480	COG3179	chitinase
ND012_10505	COG1403	HNH endonuclease
ND012_10520	COG4725	Belongs to the MT-A70-like family
ND012_10525	COG1802	Transcriptional regulator
ND012_10525	COG4626	Terminase
ND012_10560	COG5532	Uncharacterized conserved protein (DUF2303)
ND012_10565	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND012_10615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND012_10620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND012_10640	COG2223	nitrite transmembrane transporter activity
ND012_10645	COG2198	Histidine kinase
ND012_10645	COG0642	Histidine kinase
ND012_10655	COG2205	protein histidine kinase activity
ND012_10655	COG0784	Response regulator, receiver
ND012_10665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND012_10670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND012_10680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND012_10690	COG4574	serine-type endopeptidase inhibitor activity
ND012_10700	COG2246	polysaccharide biosynthetic process
ND012_10715	COG0814	amino acid
ND012_10740	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND012_10745	COG0596	Alpha beta hydrolase
ND012_10750	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND012_10755	COG1169	isochorismate synthase
ND012_10760	COG4575	ribosome binding
ND012_10775	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND012_10780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND012_10790	COG0839	Belongs to the complex I subunit 6 family
ND012_10795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND012_10800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND012_10805	COG1034	ATP synthesis coupled electron transport
ND012_10825	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND012_10830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND012_10835	COG0583	DNA-binding transcription factor activity
ND012_10840	COG0436	Aminotransferase
ND012_10845	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND012_10850	COG0490	domain, Protein
ND012_10850	COG0471	metal ion transport
ND012_10860	COG3013	Belongs to the UPF0304 family
ND012_10865	COG3092	negative regulation of chromosome organization
ND012_10875	COG0857	belongs to the CobB CobQ family
ND012_10875	COG0280	phosphate acetyltransferase
ND012_10880	COG1609	Transcriptional regulator
ND012_10895	COG3037	sugar-specific permease SgaT UlaA
ND012_10900	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND012_10905	COG0622	Phosphoesterase
ND012_10915	COG0625	glutathione transferase activity
ND012_10920	COG1090	epimerase
ND012_10930	COG4160	amino acid transport
ND012_10935	COG4215	(ABC) transporter
ND012_10950	COG0163	prenyltransferase activity
ND012_10955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND012_10960	COG1286	toxin biosynthetic process
ND012_10965	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND012_10970	COG0285	dihydrofolate synthase activity
ND012_10980	COG0586	Pfam SNARE associated Golgi protein
ND012_10990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND012_11015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND012_11020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND012_11050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND012_11065	COG3101	peptidyl-lysine hydroxylation
ND012_11070	COG0730	response to heat
ND012_11075	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND012_11085	COG2890	protein-(glutamine-N5) methyltransferase activity
ND012_11090	COG2840	Smr protein MutS2
ND012_11095	COG2062	phosphohistidine phosphatase, SixA
ND012_11100	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND012_11100	COG1024	Enoyl-CoA hydratase
ND012_11105	COG0183	Belongs to the thiolase family
ND012_11110	COG3691	Protein conserved in bacteria
ND012_11125	COG4235	cytochrome complex assembly
ND012_11125	COG3088	subunit of a heme lyase
ND012_11130	COG3088	subunit of a heme lyase
ND012_11130	COG4235	cytochrome complex assembly
ND012_11135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND012_11140	COG1138	Cytochrome C-type biogenesis protein
ND012_11145	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND012_11150	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND012_11155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND012_11160	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND012_11180	COG2824	Alkylphosphonate utilization operon protein PhnA
ND012_11185	COG2951	lytic endotransglycosylase activity
ND012_11190	COG1598	PFAM Uncharacterised protein family UPF0150
ND012_11200	COG3038	cytochrome b561
ND012_11205	COG0436	Aminotransferase
ND012_11215	COG3275	phosphorelay sensor kinase activity
ND012_11220	COG3279	Response regulator of the LytR AlgR family
ND012_11225	COG2223	nitrite transmembrane transporter activity
ND012_11230	COG0837	glucose binding
ND012_11250	COG1914	H( )-stimulated, divalent metal cation uptake system
ND012_11255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND012_11310	COG3530	Putative quorum-sensing-regulated virulence factor
ND012_11315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND012_11325	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND012_11335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND012_11350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND012_11360	COG4208	sulfate ABC transporter
ND012_11365	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND012_11370	COG4150	thiosulfate binding
ND012_11380	COG1737	Transcriptional regulator
ND012_11385	COG2731	YhcH YjgK YiaL family protein
ND012_11400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND012_11405	COG2837	iron assimilation
ND012_11415	COG3111	PFAM Bacterial OB fold (BOF) protein
ND012_11495	COG1671	Belongs to the UPF0178 family
ND012_11500	COG0281	malic enzyme
ND012_11500	COG0280	phosphate acetyltransferase
ND012_11505	COG0494	nUDIX hydrolase
ND012_11510	COG3005	denitrification pathway
ND012_11515	COG3043	anaerobic respiration
ND012_11520	COG0243	molybdopterin cofactor binding
ND012_11525	COG3062	negative regulation of establishment of protein localization
ND012_11530	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND012_11530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND012_11535	COG2197	response regulator
ND012_11545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND012_11555	COG1605	Chorismate mutase
ND012_11560	COG1393	Belongs to the ArsC family
ND012_11565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND012_11570	COG1876	peptidase activity
ND012_11580	COG0400	carboxylic ester hydrolase activity
ND012_11600	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND012_11605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND012_11610	COG2716	regulation of RNA biosynthetic process
ND012_11615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND012_11620	COG0628	permease
ND012_11625	COG4783	chaperone-mediated protein folding
ND012_11630	COG1393	Belongs to the ArsC family
ND012_11635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND012_11640	COG2233	PERMEase
ND012_11645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND012_11650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND012_11655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND012_11660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND012_11670	COG0581	inorganic phosphate transmembrane transporter activity
ND012_11675	COG0573	inorganic phosphate transmembrane transporter activity
ND012_11680	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND012_11695	COG2239	Acts as a magnesium transporter
ND012_11700	COG0443	Heat shock 70 kDa protein
ND012_11710	COG3121	Chaperone
ND012_11730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND012_11740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND012_11745	COG0477	Major facilitator Superfamily
ND012_11750	COG2205	protein histidine kinase activity
ND012_11755	COG0745	RESPONSE REGULATOR receiver
ND012_11760	COG3422	double-strand break repair
ND012_11765	COG0826	peptidase U32
ND012_11770	COG1597	lipid kinase activity
ND012_11785	COG0351	phosphomethylpyrimidine kinase
ND012_11805	COG0519	Catalyzes the synthesis of GMP from XMP
ND012_11805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND012_11810	COG0517	IMP dehydrogenase activity
ND012_11810	COG0516	GMP reductase activity
ND012_11815	COG1570	exodeoxyribonuclease VII activity
ND012_11820	COG1645	bacterial-type flagellum-dependent swarming motility
ND012_11830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND012_11835	COG2976	Protein conserved in bacteria
ND012_11840	COG0124	histidyl-tRNA synthetase
ND012_11860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND012_11875	COG4953	penicillin-binding protein 1C
ND012_11880	COG2373	Large extracellular alpha-helical protein
ND012_11895	COG2975	iron-sulfur cluster assembly
ND012_11900	COG0633	Ferredoxin
ND012_11905	COG0443	Heat shock 70 kDa protein
ND012_11920	COG0822	iron-sulfur transferase activity
ND012_11930	COG1959	2 iron, 2 sulfur cluster binding
ND012_11935	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND012_11945	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND012_11950	COG3683	transport system, periplasmic component
ND012_11955	COG3711	transcriptional antiterminator
ND012_11960	COG2814	Major facilitator Superfamily
ND012_11970	COG1017	nitric oxide dioxygenase activity
ND012_11970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND012_11975	COG2188	Transcriptional regulator
ND012_11985	COG3457	Alanine racemase
ND012_11990	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND012_12005	COG0347	Belongs to the P(II) protein family
ND012_12010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND012_12010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND012_12015	COG2204	response regulator
ND012_12020	COG3170	Tfp pilus assembly protein FimV
ND012_12025	COG2205	protein histidine kinase activity
ND012_12040	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND012_12050	COG0560	Phosphoserine phosphatase
ND012_12055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND012_12055	COG1263	PTS System
ND012_12065	COG1737	Transcriptional regulator
ND012_12070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND012_12080	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND012_12090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND012_12105	COG0481	GTPase activity
ND012_12110	COG3086	response to oxidative stress
ND012_12120	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND012_12130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND012_12140	COG0513	Belongs to the DEAD box helicase family
ND012_12155	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND012_12165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND012_12170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND012_12175	COG0497	DNA recombination
ND012_12180	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND012_12190	COG2867	negative regulation of translational initiation
ND012_12195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND012_12205	COG0582	viral genome integration into host DNA
ND012_12320	COG3121	Chaperone
ND012_12325	COG3188	usher protein
ND012_12420	COG1069	ribulokinase activity
ND012_12430	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND012_12435	COG1129	ABC transporter
ND012_12455	COG1620	l-lactate permease
ND012_12460	COG1304	FMN binding
ND012_12465	COG0579	oxidoreductase
ND012_12470	COG1278	Cold shock
ND012_12500	COG1780	Probably involved in ribonucleotide reductase function
ND012_12505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND012_12515	COG4175	Glycine betaine
ND012_12520	COG4176	ABC-type proline glycine betaine transport system permease component
ND012_12525	COG2113	Glycine betaine
ND012_12530	COG2814	Major facilitator Superfamily
ND012_12535	COG1846	Transcriptional regulator
ND012_12545	COG1566	PFAM secretion protein HlyD family protein
ND012_12550	COG2814	Major facilitator Superfamily
ND012_12555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND012_12560	COG3118	belongs to the thioredoxin family
ND012_12565	COG3148	PFAM DTW domain containing protein
ND012_12570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND012_12570	COG1042	CoA-binding domain protein
ND012_12570	COG0045	succinate-CoA ligase (ADP-forming) activity
ND012_12575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND012_12580	COG5544	Lipoprotein
ND012_12605	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND012_12615	COG2011	ABC-type metal ion transport system permease component
ND012_12620	COG1464	Belongs to the NlpA lipoprotein family
ND012_12630	COG1720	tRNA m6t6A37 methyltransferase activity
ND012_12635	COG0442	prolyl-tRNA aminoacylation
ND012_12640	COG3015	lipoprotein NlpE involved in copper resistance
ND012_12650	COG4681	YaeQ
ND012_12660	COG4568	rho-dependent transcription termination
ND012_12675	COG0346	lactoylglutathione lyase activity
ND012_12690	COG0825	malonyl-CoA metabolic process
ND012_12695	COG0587	DNA-directed DNA polymerase activity
ND012_12700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND012_12720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND012_12725	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND012_12735	COG0750	zinc metalloprotease
ND012_12740	COG0575	Belongs to the CDS family
ND012_12760	COG0528	UMP kinase activity
ND012_12765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND012_12785	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND012_12790	COG2171	N-acyltransferase activity
ND012_12805	COG0564	pseudouridine synthase activity
ND012_12810	COG3098	single-species biofilm formation
ND012_12825	COG1611	Belongs to the LOG family
ND012_12835	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND012_12840	COG2363	Small membrane protein
ND012_12845	COG0583	DNA-binding transcription factor activity
ND012_12855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND012_12860	COG2166	iron-sulfur cluster assembly
ND012_12865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND012_12870	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND012_12890	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND012_12895	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND012_12895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND012_12900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND012_12905	COG1074	ATP-dependent DNA helicase activity
ND012_12910	COG1025	Belongs to the peptidase M16 family
ND012_12915	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND012_12920	COG4967	type IV pilus modification protein PilV
ND012_12945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND012_12950	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND012_12960	COG3066	DNA modification
ND012_12965	COG0861	Integral membrane protein TerC family
ND012_12970	COG0667	Aldo Keto reductase
ND012_12975	COG0477	Major facilitator Superfamily
ND012_12980	COG0318	PFAM AMP-dependent synthetase and ligase
ND012_12980	COG0204	Acyl-transferase
ND012_12990	COG1609	Transcriptional regulator
ND012_13000	COG0583	DNA-binding transcription factor activity
ND012_13005	COG0583	DNA-binding transcription factor activity
ND012_13060	COG2165	general secretion pathway protein
ND012_13070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND012_13100	COG1127	ABC transporter
ND012_13105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND012_13115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND012_13125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND012_13130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND012_13135	COG4974	Belongs to the 'phage' integrase family
ND012_13140	COG0716	FMN binding
ND012_13150	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND012_13160	COG1272	protein, Hemolysin III
ND012_13180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND012_13185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND012_13190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND012_13195	COG0006	proline dipeptidase activity
ND012_13205	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND012_13215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND012_13220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND012_13225	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND012_13240	COG1279	arginine transmembrane transporter activity
ND012_13250	COG0191	fructose-bisphosphate aldolase activity
ND012_13255	COG0126	phosphoglycerate kinase activity
ND012_13260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND012_13265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND012_13275	COG1166	arginine decarboxylase activity
ND012_13280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND012_13295	COG0640	Transcriptional regulator
ND012_13300	COG3091	SprT-like family
ND012_13305	COG2356	endonuclease I
ND012_13310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND012_13315	COG0189	ligase activity
ND012_13320	COG1678	Uncharacterized ACR, COG1678
ND012_13325	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND012_13330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND012_13340	COG2805	Type II/IV secretion system protein
ND012_13345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND012_13350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND012_13355	COG0762	integral membrane protein
ND012_13360	COG1872	DUF167
ND012_13365	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND012_13370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND012_13385	COG3171	Protein conserved in bacteria
ND012_13395	COG1194	a g-specific adenine glycosylase
ND012_13400	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND012_13405	COG0741	lytic transglycosylase activity
ND012_13440	COG1105	Belongs to the carbohydrate kinase PfkB family
ND012_13445	COG1882	Formate acetyltransferase
ND012_13450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND012_13455	COG0814	amino acid
ND012_13470	COG1028	Short-chain dehydrogenase reductase Sdr
ND012_13475	COG1535	isochorismatase
ND012_13475	COG3433	isochorismatase activity
ND012_13480	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND012_13485	COG1169	isochorismate synthase
ND012_13490	COG4592	Periplasmic binding protein
ND012_13500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND012_13505	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND012_13510	COG1120	ATPase activity
ND012_13520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND012_13525	COG3251	PFAM MbtH domain protein
ND012_13535	COG4774	siderophore transport
ND012_13540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND012_13565	COG4964	Belongs to the GSP D family
ND012_13615	COG0848	biopolymer transport protein
ND012_13620	COG0811	peptide transport
ND012_13625	COG0626	cystathionine gamma-synthase activity
ND012_13630	COG0586	Pfam SNARE associated Golgi protein
ND012_13635	COG2207	Transcriptional regulator
ND012_13640	COG1979	alcohol dehydrogenase
ND012_13645	COG0656	L-ascorbic acid biosynthetic process
ND012_13655	COG2132	Multicopper oxidase
ND012_13665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ND012_13670	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND012_13675	COG0583	DNA-binding transcription factor activity
ND012_13680	COG0187	DNA topoisomerase II activity
ND012_13685	COG3150	esterase
ND012_13690	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND012_13695	COG3151	Protein conserved in bacteria
ND012_13700	COG0494	nUDIX hydrolase
ND012_13705	COG1538	Outer membrane efflux protein
ND012_13710	COG5463	Belongs to the UPF0441 family
ND012_13715	COG0754	glutathionylspermidine amidase activity
ND012_13720	COG3384	dioxygenase
ND012_13725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND012_13740	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND012_13740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND012_13750	COG3025	triphosphatase activity
ND012_13755	COG4991	sh3 domain protein
ND012_13760	COG0617	tRNA 3'-terminal CCA addition
ND012_13765	COG1968	undecaprenyl-diphosphatase activity
ND012_13770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND012_13775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND012_13780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND012_13785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND012_13790	COG0358	DNA primase activity
ND012_13820	COG2003	Belongs to the UPF0758 family
ND012_13845	COG2378	regulation of single-species biofilm formation
ND012_13855	COG2378	regulation of single-species biofilm formation
ND012_13860	COG3596	GTP binding
ND012_13930	COG1028	Short-chain dehydrogenase reductase Sdr
ND012_13960	COG0463	Glycosyl transferase, family 2
ND012_13975	COG3210	domain, Protein
ND012_13980	COG2831	hemolysin activation secretion protein
ND012_13985	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND012_13985	COG1902	pentaerythritol trinitrate reductase activity
ND012_14000	COG1451	nucleotide metabolic process
ND012_14005	COG0673	inositol 2-dehydrogenase activity
ND012_14010	COG0861	Integral membrane protein TerC family
ND012_14015	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND012_14025	COG2721	sulfolactate sulfo-lyase activity
ND012_14040	COG2271	Major facilitator Superfamily
ND012_14055	COG0586	Pfam SNARE associated Golgi protein
ND012_14070	COG4575	ribosome binding
ND012_14075	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND012_14085	COG2259	Doxx family
ND012_14090	COG0583	DNA-binding transcription factor activity
ND012_14095	COG1741	Belongs to the pirin family
ND012_14110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ND012_14125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND012_14130	COG2823	Periplasmic or secreted lipoprotein
ND012_14135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND012_14140	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND012_14145	COG2198	Histidine kinase
ND012_14145	COG5002	protein histidine kinase activity
ND012_14145	COG0784	Response regulator, receiver
ND012_14150	COG1242	4 iron, 4 sulfur cluster binding
ND012_14155	COG0070	glutamate synthase
ND012_14155	COG0067	glutamate synthase
ND012_14155	COG0069	glutamate synthase activity
ND012_14160	COG0493	'glutamate synthase
ND012_14170	COG2969	positive regulation of protein catabolic process
ND012_14175	COG0625	glutathione transferase activity
ND012_14180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND012_14185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND012_14190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND012_14195	COG3105	Protein conserved in bacteria
ND012_14200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND012_14210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND012_14215	COG5007	Belongs to the BolA IbaG family
ND012_14220	COG3113	response to antibiotic
ND012_14225	COG2854	intermembrane phospholipid transfer
ND012_14230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND012_14235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND012_14240	COG1127	ABC transporter
ND012_14245	COG0530	calcium, potassium:sodium antiporter activity
ND012_14250	COG0517	IMP dehydrogenase activity
ND012_14250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND012_14255	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND012_14260	COG3117	lipopolysaccharide transmembrane transporter activity
ND012_14265	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND012_14270	COG1137	ATPase activity
ND012_14275	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND012_14295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND012_14300	COG0540	Belongs to the ATCase OTCase family
ND012_14305	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND012_14315	COG0366	Alpha amylase catalytic
ND012_14320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND012_14320	COG1263	PTS System
ND012_14330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND012_14340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND012_14345	COG3783	Cytochrome b(562)
ND012_14350	COG0312	modulator of DNA gyrase
ND012_14355	COG3028	Belongs to the UPF0307 family
ND012_14360	COG2732	(Barnase) inhibitor
ND012_14365	COG4290	ribonuclease
ND012_14375	COG1289	transmembrane transporter activity
ND012_14380	COG1566	PFAM secretion protein HlyD family protein
ND012_14390	COG0583	DNA-binding transcription factor activity
ND012_14395	COG0312	modulator of DNA gyrase
ND012_14400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND012_14405	COG3164	Protein of unknown function
ND012_14415	COG0424	maF-like protein
ND012_14420	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND012_14425	COG1792	Involved in formation and maintenance of cell shape
ND012_14430	COG1077	Cell shape determining protein MreB Mrl
ND012_14435	COG2199	diguanylate cyclase activity
ND012_14435	COG2200	EAL domain
ND012_14440	COG0604	alcohol dehydrogenase
ND012_14445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND012_14450	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND012_14460	COG0511	ligase activity, forming carbon-carbon bonds
ND012_14465	COG0439	Biotin carboxylase
ND012_14470	COG3924	membrane
ND012_14475	COG4145	pantothenate transmembrane transporter activity
ND012_14480	COG2264	protein methyltransferase activity
ND012_14485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND012_14490	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND012_14500	COG1560	Kdo2-lipid A biosynthetic process
ND012_14510	COG1346	cytolysis
ND012_14515	COG1380	Effector of murein hydrolase LrgA
ND012_14520	COG0583	DNA-binding transcription factor activity
ND012_14525	COG0025	NhaP-type Na H and K H
ND012_14530	COG2252	PERMEase
ND012_14545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND012_14550	COG2315	Protein conserved in bacteria
ND012_14555	COG1448	Aminotransferase
ND012_14570	COG0604	alcohol dehydrogenase
ND012_14580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND012_14585	COG0735	belongs to the Fur family
ND012_14590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND012_14595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND012_14600	COG2937	Belongs to the GPAT DAPAT family
ND012_14620	COG4580	involved in the transport of maltose and maltodextrins
ND012_14635	COG2182	Extracellular solute-binding protein
ND012_14640	COG1175	transmembrane transport
ND012_14645	COG3833	ABC-type maltose transport systems, permease component
ND012_14650	COG3223	Belongs to the PsiE family
ND012_14660	COG0527	aspartate kinase activity
ND012_14685	COG1222	aaa ATPase
ND012_14765	COG0583	DNA-binding transcription factor activity
ND012_14800	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND012_14840	COG0138	bifunctional purine biosynthesis protein purh
ND012_14845	COG0151	Belongs to the GarS family
ND012_14865	COG1515	deoxyribonuclease V activity
ND012_14870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND012_14875	COG2816	NAD+ diphosphatase activity
ND012_14880	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND012_14895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND012_14900	COG2104	thiamine diphosphate biosynthetic process
ND012_14905	COG2022	thiamine diphosphate biosynthetic process
ND012_14915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND012_14920	COG0085	RNA polymerase activity
ND012_14925	COG0222	ribosome binding
ND012_14930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND012_14940	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND012_14945	COG0250	Participates in transcription elongation, termination and antitermination
ND012_14990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND012_15020	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND012_15025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND012_15030	COG1739	Uncharacterized protein family UPF0029
ND012_15040	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND012_15040	COG1024	Enoyl-CoA hydratase
ND012_15050	COG0543	2 iron, 2 sulfur cluster binding
ND012_15065	COG0250	Participates in transcription elongation, termination and antitermination
ND012_15080	COG0805	protein transport
ND012_15085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND012_15090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND012_15095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND012_15100	COG3165	ubiquinone biosynthetic process from chorismate
ND012_15105	COG2226	methyltransferase
ND012_15110	COG1322	Protein conserved in bacteria
ND012_15115	COG0586	Pfam SNARE associated Golgi protein
ND012_15120	COG1966	Carbon starvation protein
ND012_15135	COG0412	Dienelactone hydrolase
ND012_15140	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND012_15145	COG0583	DNA-binding transcription factor activity
ND012_15150	COG0697	spore germination
ND012_15160	COG0584	glycerophosphoryl diester phosphodiesterase
ND012_15170	COG0395	ABC-type sugar transport system, permease component
ND012_15175	COG1175	transmembrane transport
ND012_15180	COG1653	transport
ND012_15225	COG0410	ABC transporter
ND012_15235	COG4177	L-phenylalanine transmembrane transporter activity
ND012_15255	COG1929	Belongs to the glycerate kinase type-1 family
ND012_15260	COG2610	gluconate transmembrane transporter activity
ND012_15265	COG3835	regulator
ND012_15275	COG2177	Part of the ABC transporter FtsEX involved in
ND012_15280	COG2884	Cell division ATP-binding protein ftsE
ND012_15285	COG0552	protein localization to endoplasmic reticulum
ND012_15285	COG0552	protein localization to endoplasmic reticulum
ND012_15290	COG0742	ribosomal rna small subunit methyltransferase
ND012_15295	COG3776	membrane
ND012_15310	COG3714	YhhN family
ND012_15325	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND012_15335	COG0247	lactate metabolic process
ND012_15345	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND012_15355	COG2271	Major facilitator Superfamily
ND012_15360	COG0584	glycerophosphoryl diester phosphodiesterase
ND012_15365	COG0561	phosphatase activity
ND012_15370	COG2267	carboxylic ester hydrolase activity
ND012_15375	COG1280	lysine exporter protein (LysE YggA)
ND012_15380	COG0514	ATP-dependent DNA helicase (RecQ)
ND012_15385	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND012_15390	COG2050	protein possibly involved in aromatic compounds catabolism
ND012_15410	COG5564	TIM-barrel signal transduction protein
ND012_15415	COG5441	Belongs to the UPF0261 family
ND012_15425	COG0210	DNA helicase
ND012_15430	COG1011	Hydrolase
ND012_15435	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND012_15440	COG3159	Protein conserved in bacteria
ND012_15445	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND012_15450	COG5567	small periplasmic lipoprotein
ND012_15460	COG3072	Adenylate cyclase
ND012_15465	COG0181	hydroxymethylbilane synthase activity
ND012_15470	COG1587	Uroporphyrinogen-III synthase
ND012_15475	COG2959	enzyme of heme biosynthesis
ND012_15480	COG3071	HemY protein
ND012_15525	COG2244	polysaccharide biosynthetic process
ND012_15530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND012_15535	COG0456	acetyltransferase
ND012_15540	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND012_15545	COG1088	dTDP-glucose 4,6-dehydratase activity
ND012_15550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND012_15555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND012_15560	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND012_15565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND012_15570	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND012_15575	COG3118	belongs to the thioredoxin family
ND012_15585	COG0248	Ppx GppA phosphatase
ND012_15595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND012_15610	COG3397	chitin binding
ND012_15620	COG0129	dihydroxy-acid dehydratase activity
ND012_15630	COG3978	acetolactate synthase activity
ND012_15650	COG3085	chromosome segregation
ND012_15655	COG0583	DNA-binding transcription factor activity
ND012_15725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND012_15735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND012_15735	COG0678	peroxiredoxin activity
ND012_15740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND012_15775	COG1629	transport
ND012_15780	COG0165	Argininosuccinate lyase
ND012_15785	COG0137	argininosuccinate synthase activity
ND012_15790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND012_15860	COG1561	YicC-like family, N-terminal region
ND012_15865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND012_15870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND012_15875	COG1309	transcriptional regulator
ND012_15880	COG0756	dUTP diphosphatase activity
ND012_15885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND012_15890	COG2003	Belongs to the UPF0758 family
ND012_15895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND012_15900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND012_15920	COG1519	Transferase
ND012_15925	COG0859	PFAM glycosyl transferase family 9
ND012_15930	COG0859	PFAM glycosyl transferase family 9
ND012_15935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND012_15950	COG2861	carbohydrate metabolic process
ND012_15955	COG4942	peptidase
ND012_15960	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND012_15965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND012_15970	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND012_15975	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND012_15980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND012_15985	COG1045	serine acetyltransferase
ND012_15990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND012_15995	COG2205	protein histidine kinase activity
ND012_16000	COG0745	RESPONSE REGULATOR receiver
ND012_16005	COG3678	ATP-independent chaperone mediated protein folding
ND012_16010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND012_16020	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND012_16035	COG3152	Membrane
ND012_16045	COG2814	Major facilitator Superfamily
ND012_16050	COG1494	fructose-1,6-bisphosphatase
ND012_16055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND012_16060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND012_16065	COG3074	FtsZ-dependent cytokinesis
ND012_16070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND012_16075	COG1575	Belongs to the MenA family. Type 1 subfamily
ND012_16080	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND012_16085	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND012_16090	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND012_16095	COG1609	Transcriptional regulator
ND012_16100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND012_16110	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND012_16115	COG0626	cystathionine gamma-synthase activity
ND012_16120	COG0460	homoserine dehydrogenase
ND012_16120	COG0527	aspartate kinase activity
ND012_16145	COG5001	Diguanylate cyclase
ND012_16150	COG1024	Enoyl-CoA hydratase
ND012_16155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND012_16170	COG2860	membrane
ND012_16175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND012_16185	COG1758	RNA polymerase activity
ND012_16190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND012_16195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND012_16200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND012_16205	COG0786	glutamate:sodium symporter activity
ND012_16210	COG2233	PERMEase
ND012_16215	COG2982	Protein involved in outer membrane biogenesis
ND012_16220	COG0456	acetyltransferase
ND012_16235	COG1011	Hydrolase
ND012_16250	COG3852	Histidine kinase
ND012_16260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND012_16270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND012_16275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND012_16275	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND012_16280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND012_16285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND012_16290	COG3084	Protein conserved in bacteria
ND012_16300	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND012_16325	COG2186	Transcriptional regulator
ND012_16330	COG1609	Transcriptional regulator
ND012_16335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND012_16345	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND012_16350	COG1129	ABC transporter
ND012_16355	COG1869	D-ribose catabolic process
ND012_16360	COG3158	transport of potassium into the cell
ND012_16365	COG0714	Associated with various cellular activities
ND012_16370	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND012_16380	COG2502	aspartate--ammonia ligase
ND012_16385	COG1522	sequence-specific DNA binding
ND012_16390	COG0716	FMN binding
ND012_16395	COG0445	tRNA wobble uridine modification
ND012_16400	COG0357	Ribosomal RNA small subunit methyltransferase G
ND012_16405	COG3312	ion transport
ND012_16410	COG0356	it plays a direct role in the translocation of protons across the membrane
ND012_16420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND012_16430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND012_16435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND012_16445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND012_16460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND012_16465	COG0573	inorganic phosphate transmembrane transporter activity
ND012_16470	COG0581	inorganic phosphate transmembrane transporter activity
ND012_16480	COG0704	Plays a role in the regulation of phosphate uptake
ND012_16485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND012_16490	COG0765	amino acid transport
ND012_16500	COG2252	PERMEase
ND012_16505	COG0840	transmembrane signaling receptor activity
ND012_16515	COG3121	Chaperone
ND012_16530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND012_16535	COG0706	membrane insertase activity
ND012_16545	COG0594	ribonuclease P activity
ND012_16550	COG0230	Belongs to the bacterial ribosomal protein bL34 family