locus-tag	class	description
ND437_00010	COG0592	DNA-directed DNA polymerase activity
ND437_00020	COG0187	DNA topoisomerase II activity
ND437_00025	COG0561	phosphatase activity
ND437_00030	COG0823	Involved in the tonB-independent uptake of proteins
ND437_00035	COG5645	(Lipo)protein
ND437_00050	COG0569	domain protein
ND437_00050	COG2985	domain, Protein
ND437_00055	COG3977	Valine--pyruvate aminotransferase
ND437_00060	COG2885	chlorophyll binding
ND437_00080	COG2818	Glycosylase
ND437_00130	COG2213	PTS system mannitol-specific
ND437_00130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND437_00140	COG3722	fumarate hydratase activity
ND437_00150	COG2258	MOSC domain
ND437_00155	COG0840	transmembrane signaling receptor activity
ND437_00160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND437_00175	COG0437	4 iron, 4 sulfur cluster binding
ND437_00180	COG2864	formate dehydrogenase
ND437_00190	COG1921	L-seryl-tRNASec selenium transferase activity
ND437_00195	COG3276	selenocysteine insertion sequence binding
ND437_00200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND437_00210	COG3274	enterobacterial common antigen metabolic process
ND437_00245	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND437_00250	COG2986	histidine ammonia-lyase
ND437_00270	COG2194	sulfuric ester hydrolase activity
ND437_00275	COG2197	response regulator
ND437_00280	COG3851	Histidine kinase
ND437_00285	COG2271	Major facilitator Superfamily
ND437_00295	COG0747	negative chemotaxis
ND437_00300	COG0601	transmembrane transport
ND437_00305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND437_00310	COG0444	Belongs to the ABC transporter superfamily
ND437_00315	COG4608	Belongs to the ABC transporter superfamily
ND437_00320	COG2194	sulfuric ester hydrolase activity
ND437_00345	COG1215	transferase activity, transferring glycosyl groups
ND437_00350	COG1215	transferase activity, transferring glycosyl groups
ND437_00355	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND437_00360	COG3118	belongs to the thioredoxin family
ND437_00360	COG0457	Tetratricopeptide repeat
ND437_00365	COG2200	EAL domain
ND437_00365	COG2199	diguanylate cyclase activity
ND437_00370	COG1301	dicarboxylic acid transport
ND437_00375	COG0612	Peptidase, M16
ND437_00380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND437_00385	COG1942	4-Oxalocrotonate Tautomerase
ND437_00390	COG2200	EAL domain
ND437_00395	COG2134	cdp-diacylglycerol pyrophosphatase
ND437_00400	COG1295	ribonuclease BN
ND437_00410	COG1301	dicarboxylic acid transport
ND437_00415	COG0626	cystathionine gamma-synthase activity
ND437_00435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND437_00440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND437_00445	COG0339	signal peptide processing
ND437_00450	COG0742	ribosomal rna small subunit methyltransferase
ND437_00460	COG0589	response to stress
ND437_00470	COG0306	phosphate transporter
ND437_00475	COG2081	HI0933 family
ND437_00485	COG1247	-acetyltransferase
ND437_00490	COG1741	Belongs to the pirin family
ND437_00495	COG1609	Transcriptional regulator
ND437_00500	COG2610	gluconate transmembrane transporter activity
ND437_00505	COG3265	gluconokinase activity
ND437_00510	COG2095	MarC family integral membrane protein
ND437_00515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND437_00520	COG3275	phosphorelay sensor kinase activity
ND437_00525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND437_00530	COG1523	belongs to the glycosyl hydrolase 13 family
ND437_00535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND437_00540	COG0297	glycogen (starch) synthase activity
ND437_00545	COG0058	SHG alpha-glucan phosphorylase activity
ND437_00550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND437_00585	COG1349	DNA-binding transcription factor activity
ND437_00590	COG0705	Rhomboid family
ND437_00600	COG2909	trisaccharide binding
ND437_00605	COG0058	SHG alpha-glucan phosphorylase activity
ND437_00610	COG1640	4-alpha-glucanotransferase
ND437_00620	COG1040	competence protein
ND437_00625	COG0596	Alpha beta hydrolase
ND437_00645	COG1918	ferrous iron import across plasma membrane
ND437_00650	COG2183	response to ionizing radiation
ND437_00675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND437_00690	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND437_00700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND437_00705	COG1011	Hydrolase
ND437_00715	COG0494	nUDIX hydrolase
ND437_00720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND437_00745	COG4796	Type ii and iii secretion system protein
ND437_00750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND437_00770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND437_00780	COG0180	Tryptophanyl-tRNA synthetase
ND437_00800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND437_00805	COG0402	S-adenosylhomocysteine deaminase activity
ND437_00810	COG0738	Major facilitator superfamily
ND437_00825	COG1609	Transcriptional regulator
ND437_00830	COG1486	melibiose metabolic process
ND437_00835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND437_00850	COG1289	transmembrane transporter activity
ND437_00855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND437_00860	COG1765	OsmC-like protein
ND437_00885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND437_00890	COG3954	Phosphoribulokinase
ND437_00900	COG0429	hydrolase of the alpha beta-hydrolase fold
ND437_00910	COG0859	PFAM glycosyl transferase family 9
ND437_00915	COG1216	Glycosyl transferase, family 2
ND437_00920	COG0488	(ABC) transporter
ND437_00925	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND437_00935	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND437_00940	COG1047	Peptidyl-prolyl cis-trans
ND437_00950	COG0545	Peptidyl-prolyl cis-trans isomerase
ND437_00955	COG2964	Protein conserved in bacteria
ND437_00965	COG2923	Belongs to the DsrF TusC family
ND437_00970	COG2168	tRNA wobble position uridine thiolation
ND437_00975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND437_00980	COG0049	tRNA binding
ND437_00990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND437_01005	COG0051	transcription antitermination factor activity, RNA binding
ND437_01010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND437_01020	COG0089	rRNA binding
ND437_01025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND437_01030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND437_01035	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND437_01045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND437_01050	COG0255	Belongs to the universal ribosomal protein uL29 family
ND437_01055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND437_01060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND437_01070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND437_01095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND437_01100	COG1841	ribosomal large subunit assembly
ND437_01105	COG0200	Binds to the 23S rRNA
ND437_01110	COG0201	protein transport
ND437_01115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND437_01120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND437_01130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND437_01140	COG0203	ribosomal protein L17
ND437_01145	COG0789	Transcriptional regulator
ND437_01150	COG3036	rescue of stalled ribosome
ND437_01155	COG1970	mechanosensitive ion channel activity
ND437_01165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND437_01165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND437_01170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND437_01175	COG0242	peptide deformylase activity
ND437_01180	COG0758	DNA mediated transformation
ND437_01185	COG2922	Belongs to the Smg family
ND437_01190	COG0551	DNA topoisomerase type I activity
ND437_01195	COG0009	L-threonylcarbamoyladenylate synthase
ND437_01205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND437_01250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND437_01285	COG0583	DNA-binding transcription factor activity
ND437_01365	COG1222	aaa ATPase
ND437_01390	COG0527	aspartate kinase activity
ND437_01400	COG3223	Belongs to the PsiE family
ND437_01405	COG3833	ABC-type maltose transport systems, permease component
ND437_01410	COG1175	transmembrane transport
ND437_01415	COG2182	Extracellular solute-binding protein
ND437_01430	COG4580	involved in the transport of maltose and maltodextrins
ND437_01450	COG2937	Belongs to the GPAT DAPAT family
ND437_01455	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND437_01460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND437_01465	COG0735	belongs to the Fur family
ND437_01470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND437_01480	COG0604	alcohol dehydrogenase
ND437_01495	COG1448	Aminotransferase
ND437_01500	COG2315	Protein conserved in bacteria
ND437_01505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND437_01520	COG2252	PERMEase
ND437_01525	COG0025	NhaP-type Na H and K H
ND437_01530	COG0583	DNA-binding transcription factor activity
ND437_01535	COG1380	Effector of murein hydrolase LrgA
ND437_01540	COG1346	cytolysis
ND437_01550	COG1560	Kdo2-lipid A biosynthetic process
ND437_01560	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND437_01565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND437_01570	COG2264	protein methyltransferase activity
ND437_01575	COG4145	pantothenate transmembrane transporter activity
ND437_01580	COG3924	membrane
ND437_01585	COG0439	Biotin carboxylase
ND437_01590	COG0511	ligase activity, forming carbon-carbon bonds
ND437_01600	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND437_01605	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND437_01610	COG0604	alcohol dehydrogenase
ND437_01615	COG2200	EAL domain
ND437_01615	COG2199	diguanylate cyclase activity
ND437_01620	COG1077	Cell shape determining protein MreB Mrl
ND437_01625	COG1792	Involved in formation and maintenance of cell shape
ND437_01630	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND437_01635	COG0424	maF-like protein
ND437_01645	COG3164	Protein of unknown function
ND437_01650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND437_01655	COG0312	modulator of DNA gyrase
ND437_01660	COG0583	DNA-binding transcription factor activity
ND437_01670	COG1566	PFAM secretion protein HlyD family protein
ND437_01675	COG1289	transmembrane transporter activity
ND437_01685	COG4290	ribonuclease
ND437_01690	COG2732	(Barnase) inhibitor
ND437_01695	COG3028	Belongs to the UPF0307 family
ND437_01700	COG0312	modulator of DNA gyrase
ND437_01705	COG3783	Cytochrome b(562)
ND437_01710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND437_01720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND437_01730	COG1263	PTS System
ND437_01730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND437_01735	COG0366	Alpha amylase catalytic
ND437_01745	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND437_01750	COG0540	Belongs to the ATCase OTCase family
ND437_01755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND437_01775	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND437_01780	COG1137	ATPase activity
ND437_01785	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND437_01790	COG3117	lipopolysaccharide transmembrane transporter activity
ND437_01795	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND437_01800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND437_01800	COG0517	IMP dehydrogenase activity
ND437_01805	COG0530	calcium, potassium:sodium antiporter activity
ND437_01810	COG1127	ABC transporter
ND437_01815	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND437_01820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND437_01825	COG2854	intermembrane phospholipid transfer
ND437_01830	COG3113	response to antibiotic
ND437_01835	COG5007	Belongs to the BolA IbaG family
ND437_01840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND437_01850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND437_01855	COG3105	Protein conserved in bacteria
ND437_01860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND437_01865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND437_01870	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND437_01875	COG0625	glutathione transferase activity
ND437_01880	COG2969	positive regulation of protein catabolic process
ND437_01890	COG0493	'glutamate synthase
ND437_01895	COG0067	glutamate synthase
ND437_01895	COG0069	glutamate synthase activity
ND437_01895	COG0070	glutamate synthase
ND437_01900	COG1242	4 iron, 4 sulfur cluster binding
ND437_01910	COG5002	protein histidine kinase activity
ND437_01910	COG2198	Histidine kinase
ND437_01910	COG0784	Response regulator, receiver
ND437_01915	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND437_01920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND437_01925	COG2823	Periplasmic or secreted lipoprotein
ND437_01930	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND437_01945	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ND437_01960	COG1741	Belongs to the pirin family
ND437_01965	COG0583	DNA-binding transcription factor activity
ND437_01970	COG2259	Doxx family
ND437_01980	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND437_01985	COG4575	ribosome binding
ND437_02000	COG0586	Pfam SNARE associated Golgi protein
ND437_02015	COG2271	Major facilitator Superfamily
ND437_02030	COG2721	sulfolactate sulfo-lyase activity
ND437_02040	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND437_02045	COG0861	Integral membrane protein TerC family
ND437_02050	COG0673	inositol 2-dehydrogenase activity
ND437_02055	COG1451	nucleotide metabolic process
ND437_02070	COG1902	pentaerythritol trinitrate reductase activity
ND437_02070	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND437_02075	COG2831	hemolysin activation secretion protein
ND437_02080	COG3210	domain, Protein
ND437_02115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND437_02130	COG1028	Short-chain dehydrogenase reductase Sdr
ND437_02160	COG0358	DNA primase activity
ND437_02165	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND437_02170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND437_02175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND437_02180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND437_02185	COG1968	undecaprenyl-diphosphatase activity
ND437_02190	COG0617	tRNA 3'-terminal CCA addition
ND437_02195	COG4991	sh3 domain protein
ND437_02200	COG3025	triphosphatase activity
ND437_02210	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND437_02210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND437_02220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND437_02225	COG3384	dioxygenase
ND437_02230	COG0754	glutathionylspermidine amidase activity
ND437_02235	COG5463	Belongs to the UPF0441 family
ND437_02240	COG1538	Outer membrane efflux protein
ND437_02245	COG0494	nUDIX hydrolase
ND437_02250	COG3151	Protein conserved in bacteria
ND437_02255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND437_02260	COG3150	esterase
ND437_02265	COG0187	DNA topoisomerase II activity
ND437_02270	COG0583	DNA-binding transcription factor activity
ND437_02275	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND437_02280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ND437_02290	COG2132	Multicopper oxidase
ND437_02300	COG0656	L-ascorbic acid biosynthetic process
ND437_02305	COG1979	alcohol dehydrogenase
ND437_02310	COG2207	Transcriptional regulator
ND437_02315	COG0586	Pfam SNARE associated Golgi protein
ND437_02320	COG0626	cystathionine gamma-synthase activity
ND437_02325	COG0811	peptide transport
ND437_02330	COG0848	biopolymer transport protein
ND437_02380	COG4964	Belongs to the GSP D family
ND437_02405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND437_02410	COG4774	siderophore transport
ND437_02420	COG3251	PFAM MbtH domain protein
ND437_02425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND437_02435	COG1120	ATPase activity
ND437_02440	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND437_02445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND437_02455	COG4592	Periplasmic binding protein
ND437_02460	COG1169	isochorismate synthase
ND437_02465	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND437_02470	COG1535	isochorismatase
ND437_02470	COG3433	isochorismatase activity
ND437_02475	COG1028	Short-chain dehydrogenase reductase Sdr
ND437_02490	COG0814	amino acid
ND437_02495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND437_02500	COG1882	Formate acetyltransferase
ND437_02505	COG1105	Belongs to the carbohydrate kinase PfkB family
ND437_02515	COG1349	DNA-binding transcription factor activity
ND437_02520	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND437_02525	COG1028	Short-chain dehydrogenase reductase Sdr
ND437_02530	COG3731	PTS system glucitol sorbitol-specific IIA component
ND437_02535	COG3732	PTS system glucitol sorbitol-specific
ND437_02540	COG3730	PTS system glucitol sorbitol-specific
ND437_02560	COG0741	lytic transglycosylase activity
ND437_02565	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND437_02570	COG1194	a g-specific adenine glycosylase
ND437_02580	COG3171	Protein conserved in bacteria
ND437_02595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND437_02600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND437_02605	COG1872	DUF167
ND437_02610	COG0762	integral membrane protein
ND437_02615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND437_02620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND437_02625	COG2805	Type II/IV secretion system protein
ND437_02635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND437_02640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND437_02645	COG1678	Uncharacterized ACR, COG1678
ND437_02650	COG0189	ligase activity
ND437_02655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND437_02660	COG2356	endonuclease I
ND437_02665	COG3091	SprT-like family
ND437_02670	COG0640	Transcriptional regulator
ND437_02685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND437_02690	COG1166	arginine decarboxylase activity
ND437_02700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND437_02705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND437_02710	COG0126	phosphoglycerate kinase activity
ND437_02715	COG0191	fructose-bisphosphate aldolase activity
ND437_02725	COG1279	arginine transmembrane transporter activity
ND437_02740	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND437_02745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND437_02750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND437_02760	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND437_02770	COG0006	proline dipeptidase activity
ND437_02775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND437_02780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND437_02785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND437_02805	COG1272	protein, Hemolysin III
ND437_02815	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND437_02825	COG0716	FMN binding
ND437_02830	COG4974	Belongs to the 'phage' integrase family
ND437_02835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND437_02840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND437_02850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND437_02860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND437_02865	COG1127	ABC transporter
ND437_02895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND437_02905	COG2165	general secretion pathway protein
ND437_02965	COG0583	DNA-binding transcription factor activity
ND437_02970	COG0583	DNA-binding transcription factor activity
ND437_02980	COG1609	Transcriptional regulator
ND437_02985	COG0204	Acyl-transferase
ND437_02985	COG0318	PFAM AMP-dependent synthetase and ligase
ND437_02990	COG0477	Major facilitator Superfamily
ND437_02995	COG0667	Aldo Keto reductase
ND437_03000	COG0861	Integral membrane protein TerC family
ND437_03005	COG3066	DNA modification
ND437_03015	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND437_03020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND437_03045	COG4967	type IV pilus modification protein PilV
ND437_03050	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND437_03055	COG1025	Belongs to the peptidase M16 family
ND437_03060	COG1074	ATP-dependent DNA helicase activity
ND437_03065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND437_03070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND437_03070	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND437_03075	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND437_03095	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND437_03100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND437_03105	COG2166	iron-sulfur cluster assembly
ND437_03110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND437_03120	COG0583	DNA-binding transcription factor activity
ND437_03125	COG2363	Small membrane protein
ND437_03130	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND437_03140	COG1611	Belongs to the LOG family
ND437_03155	COG3098	single-species biofilm formation
ND437_03160	COG0564	pseudouridine synthase activity
ND437_03175	COG2171	N-acyltransferase activity
ND437_03180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND437_03200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND437_03205	COG0528	UMP kinase activity
ND437_03225	COG0575	Belongs to the CDS family
ND437_03230	COG0750	zinc metalloprotease
ND437_03240	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND437_03245	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND437_03265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND437_03270	COG0587	DNA-directed DNA polymerase activity
ND437_03275	COG0825	malonyl-CoA metabolic process
ND437_03290	COG0346	lactoylglutathione lyase activity
ND437_03305	COG4568	rho-dependent transcription termination
ND437_03315	COG4681	YaeQ
ND437_03325	COG3015	lipoprotein NlpE involved in copper resistance
ND437_03330	COG0442	prolyl-tRNA aminoacylation
ND437_03335	COG1720	tRNA m6t6A37 methyltransferase activity
ND437_03345	COG1464	Belongs to the NlpA lipoprotein family
ND437_03350	COG2011	ABC-type metal ion transport system permease component
ND437_03360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND437_03390	COG5544	Lipoprotein
ND437_03395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND437_03400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND437_03400	COG0045	succinate-CoA ligase (ADP-forming) activity
ND437_03400	COG1042	CoA-binding domain protein
ND437_03405	COG3148	PFAM DTW domain containing protein
ND437_03410	COG3118	belongs to the thioredoxin family
ND437_03415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND437_03420	COG2814	Major facilitator Superfamily
ND437_03425	COG1566	PFAM secretion protein HlyD family protein
ND437_03435	COG1846	Transcriptional regulator
ND437_03440	COG2814	Major facilitator Superfamily
ND437_03445	COG2113	Glycine betaine
ND437_03450	COG4176	ABC-type proline glycine betaine transport system permease component
ND437_03455	COG4175	Glycine betaine
ND437_03465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND437_03470	COG1780	Probably involved in ribonucleotide reductase function
ND437_03500	COG1278	Cold shock
ND437_03505	COG0579	oxidoreductase
ND437_03510	COG1304	FMN binding
ND437_03515	COG1620	l-lactate permease
ND437_03535	COG1129	ABC transporter
ND437_03540	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND437_03550	COG1069	ribulokinase activity
ND437_03625	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND437_03630	COG2867	negative regulation of translational initiation
ND437_03640	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND437_03645	COG0497	DNA recombination
ND437_03650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND437_03655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND437_03665	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND437_03680	COG0513	Belongs to the DEAD box helicase family
ND437_03690	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND437_03700	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND437_03710	COG3086	response to oxidative stress
ND437_03715	COG0481	GTPase activity
ND437_03730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND437_03740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND437_03750	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND437_03755	COG1737	Transcriptional regulator
ND437_03765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND437_03765	COG1263	PTS System
ND437_03770	COG0560	Phosphoserine phosphatase
ND437_03780	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND437_03795	COG2205	protein histidine kinase activity
ND437_03800	COG3170	Tfp pilus assembly protein FimV
ND437_03805	COG2204	response regulator
ND437_03810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND437_03810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND437_03815	COG0347	Belongs to the P(II) protein family
ND437_03830	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND437_03835	COG3457	Alanine racemase
ND437_03845	COG2188	Transcriptional regulator
ND437_03850	COG1017	nitric oxide dioxygenase activity
ND437_03850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND437_03860	COG2814	Major facilitator Superfamily
ND437_03865	COG3711	transcriptional antiterminator
ND437_03870	COG3683	transport system, periplasmic component
ND437_03875	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND437_03885	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND437_03890	COG1959	2 iron, 2 sulfur cluster binding
ND437_03900	COG0822	iron-sulfur transferase activity
ND437_03915	COG0443	Heat shock 70 kDa protein
ND437_03920	COG0633	Ferredoxin
ND437_03925	COG2975	iron-sulfur cluster assembly
ND437_03940	COG2373	Large extracellular alpha-helical protein
ND437_03945	COG4953	penicillin-binding protein 1C
ND437_03960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND437_03980	COG0124	histidyl-tRNA synthetase
ND437_03985	COG2976	Protein conserved in bacteria
ND437_03990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND437_04000	COG1645	bacterial-type flagellum-dependent swarming motility
ND437_04005	COG1570	exodeoxyribonuclease VII activity
ND437_04010	COG0517	IMP dehydrogenase activity
ND437_04010	COG0516	GMP reductase activity
ND437_04015	COG0519	Catalyzes the synthesis of GMP from XMP
ND437_04015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND437_04025	COG0351	phosphomethylpyrimidine kinase
ND437_04040	COG1597	lipid kinase activity
ND437_04045	COG0826	peptidase U32
ND437_04050	COG3422	double-strand break repair
ND437_04055	COG0745	RESPONSE REGULATOR receiver
ND437_04060	COG2205	protein histidine kinase activity
ND437_04065	COG0477	Major facilitator Superfamily
ND437_04070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND437_04080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND437_04095	COG3121	Chaperone
ND437_04105	COG0443	Heat shock 70 kDa protein
ND437_04110	COG2239	Acts as a magnesium transporter
ND437_04125	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND437_04130	COG0573	inorganic phosphate transmembrane transporter activity
ND437_04135	COG0581	inorganic phosphate transmembrane transporter activity
ND437_04145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND437_04150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND437_04155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND437_04160	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND437_04165	COG2233	PERMEase
ND437_04170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND437_04175	COG1393	Belongs to the ArsC family
ND437_04180	COG4783	chaperone-mediated protein folding
ND437_04185	COG0628	permease
ND437_04190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND437_04195	COG2716	regulation of RNA biosynthetic process
ND437_04200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND437_04205	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND437_04225	COG0400	carboxylic ester hydrolase activity
ND437_04235	COG1876	peptidase activity
ND437_04240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND437_04245	COG1393	Belongs to the ArsC family
ND437_04250	COG1605	Chorismate mutase
ND437_04260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND437_04270	COG2197	response regulator
ND437_04275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND437_04275	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND437_04280	COG3062	negative regulation of establishment of protein localization
ND437_04285	COG0243	molybdopterin cofactor binding
ND437_04290	COG3043	anaerobic respiration
ND437_04295	COG3005	denitrification pathway
ND437_04300	COG0494	nUDIX hydrolase
ND437_04305	COG0281	malic enzyme
ND437_04305	COG0280	phosphate acetyltransferase
ND437_04310	COG1671	Belongs to the UPF0178 family
ND437_04395	COG3111	PFAM Bacterial OB fold (BOF) protein
ND437_04405	COG2837	iron assimilation
ND437_04410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND437_04425	COG2731	YhcH YjgK YiaL family protein
ND437_04430	COG1737	Transcriptional regulator
ND437_04440	COG4150	thiosulfate binding
ND437_04445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND437_04450	COG4208	sulfate ABC transporter
ND437_04460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND437_04475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND437_04485	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND437_04495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND437_04500	COG3530	Putative quorum-sensing-regulated virulence factor
ND437_04575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND437_04580	COG1914	H( )-stimulated, divalent metal cation uptake system
ND437_04600	COG0837	glucose binding
ND437_04605	COG2223	nitrite transmembrane transporter activity
ND437_04610	COG3279	Response regulator of the LytR AlgR family
ND437_04615	COG3275	phosphorelay sensor kinase activity
ND437_04625	COG0436	Aminotransferase
ND437_04630	COG3038	cytochrome b561
ND437_04640	COG1598	PFAM Uncharacterised protein family UPF0150
ND437_04645	COG2951	lytic endotransglycosylase activity
ND437_04650	COG2824	Alkylphosphonate utilization operon protein PhnA
ND437_04670	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND437_04675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND437_04680	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND437_04685	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND437_04690	COG1138	Cytochrome C-type biogenesis protein
ND437_04695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND437_04700	COG4235	cytochrome complex assembly
ND437_04700	COG3088	subunit of a heme lyase
ND437_04705	COG4235	cytochrome complex assembly
ND437_04705	COG3088	subunit of a heme lyase
ND437_04720	COG3691	Protein conserved in bacteria
ND437_04725	COG0183	Belongs to the thiolase family
ND437_04730	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND437_04730	COG1024	Enoyl-CoA hydratase
ND437_04735	COG2062	phosphohistidine phosphatase, SixA
ND437_04740	COG2840	Smr protein MutS2
ND437_04745	COG2890	protein-(glutamine-N5) methyltransferase activity
ND437_04755	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND437_04760	COG0730	response to heat
ND437_04765	COG3101	peptidyl-lysine hydroxylation
ND437_04780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND437_04810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND437_04815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND437_04840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND437_04850	COG0586	Pfam SNARE associated Golgi protein
ND437_04860	COG0285	dihydrofolate synthase activity
ND437_04865	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND437_04870	COG1286	toxin biosynthetic process
ND437_04875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND437_04880	COG0163	prenyltransferase activity
ND437_04895	COG4215	(ABC) transporter
ND437_04900	COG4160	amino acid transport
ND437_04910	COG1090	epimerase
ND437_04915	COG0625	glutathione transferase activity
ND437_04925	COG0622	Phosphoesterase
ND437_04930	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND437_04935	COG3037	sugar-specific permease SgaT UlaA
ND437_04950	COG1609	Transcriptional regulator
ND437_04955	COG0857	belongs to the CobB CobQ family
ND437_04955	COG0280	phosphate acetyltransferase
ND437_04965	COG3092	negative regulation of chromosome organization
ND437_04970	COG3013	Belongs to the UPF0304 family
ND437_04980	COG0471	metal ion transport
ND437_04980	COG0490	domain, Protein
ND437_04985	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND437_04990	COG0436	Aminotransferase
ND437_04995	COG0583	DNA-binding transcription factor activity
ND437_05000	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND437_05005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND437_05025	COG1034	ATP synthesis coupled electron transport
ND437_05030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND437_05035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND437_05040	COG0839	Belongs to the complex I subunit 6 family
ND437_05050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND437_05055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND437_05070	COG4575	ribosome binding
ND437_05075	COG1169	isochorismate synthase
ND437_05080	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND437_05085	COG0596	Alpha beta hydrolase
ND437_05090	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND437_05115	COG0814	amino acid
ND437_05130	COG2246	polysaccharide biosynthetic process
ND437_05140	COG4574	serine-type endopeptidase inhibitor activity
ND437_05150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND437_05160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND437_05165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND437_05175	COG0784	Response regulator, receiver
ND437_05175	COG2205	protein histidine kinase activity
ND437_05185	COG0642	Histidine kinase
ND437_05185	COG2198	Histidine kinase
ND437_05190	COG2223	nitrite transmembrane transporter activity
ND437_05210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND437_05215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND437_05265	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND437_05270	COG5532	Uncharacterized conserved protein (DUF2303)
ND437_05305	COG1802	Transcriptional regulator
ND437_05305	COG4626	Terminase
ND437_05310	COG4725	Belongs to the MT-A70-like family
ND437_05325	COG1403	HNH endonuclease
ND437_05350	COG3179	chitinase
ND437_05400	COG0616	signal peptide processing
ND437_05440	COG4386	tail sheath protein
ND437_05485	COG3299	homolog of phage Mu protein gp47
ND437_05515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ND437_05530	COG3083	sulfuric ester hydrolase activity
ND437_05535	COG3082	Protein of unknown function (DUF1414)
ND437_05550	COG1061	Type III restriction enzyme res subunit
ND437_05555	COG1187	pseudouridine synthase activity
ND437_05560	COG2814	Major facilitator Superfamily
ND437_05570	COG4172	Belongs to the ABC transporter superfamily
ND437_05575	COG4239	(ABC) transporter, permease
ND437_05580	COG4174	ABC transporter (Permease)
ND437_05585	COG4166	transmembrane transport
ND437_05590	COG2200	EAL domain
ND437_05595	COG0791	NLP P60 protein
ND437_05600	COG0671	phosphoesterase, PA-phosphatase related
ND437_05605	COG0523	cobalamin synthesis protein
ND437_05615	COG0246	Mannitol dehydrogenase
ND437_05625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND437_05640	COG0243	molybdopterin cofactor binding
ND437_05645	COG3005	denitrification pathway
ND437_05660	COG1105	Belongs to the carbohydrate kinase PfkB family
ND437_05665	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND437_05665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND437_05665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND437_05670	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND437_05675	COG2855	membrane
ND437_05685	COG0583	DNA-binding transcription factor activity
ND437_05690	COG0833	amino acid
ND437_05700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND437_05710	COG4771	TonB-dependent receptor
ND437_05715	COG0531	amino acid
ND437_05720	COG2925	Exonuclease
ND437_05730	COG1289	transmembrane transporter activity
ND437_05750	COG3842	ATPase activity
ND437_05760	COG1840	ABC-type Fe3 transport system, periplasmic component
ND437_05765	COG2271	Major facilitator Superfamily
ND437_05780	COG4565	transcriptional regulatory protein
ND437_05785	COG3290	protein histidine kinase activity
ND437_05790	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND437_05795	COG3052	prosthetic group binding
ND437_05800	COG2301	Belongs to the HpcH HpaI aldolase family
ND437_05805	COG3051	citrate lyase alpha subunit
ND437_05820	COG0471	metal ion transport
ND437_05870	COG3321	synthase
ND437_05870	COG1028	Short-chain dehydrogenase reductase Sdr
ND437_05870	COG0604	alcohol dehydrogenase
ND437_05890	COG1609	Transcriptional regulator
ND437_05905	COG0840	transmembrane signaling receptor activity
ND437_05910	COG1285	pathogenesis
ND437_05915	COG0589	response to stress
ND437_05935	COG1360	Flagellar Motor Protein
ND437_05940	COG0643	Histidine kinase
ND437_05940	COG2198	Histidine kinase
ND437_05945	COG0835	chemotaxis
ND437_05950	COG0840	transmembrane signaling receptor activity
ND437_05955	COG0840	transmembrane signaling receptor activity
ND437_05960	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND437_05970	COG0745	RESPONSE REGULATOR receiver
ND437_05975	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND437_05980	COG4935	Belongs to the peptidase S8 family
ND437_05980	COG1404	Belongs to the peptidase S8 family
ND437_05985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND437_05990	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND437_06000	COG3418	PFAM FlgN family protein
ND437_06005	COG2747	anti-sigma28 factor FlgM
ND437_06015	COG1815	bacterial-type flagellum-dependent cell motility
ND437_06020	COG1558	bacterial-type flagellum-dependent cell motility
ND437_06100	COG1580	Controls the rotational direction of flagella during chemotaxis
ND437_06115	COG1157	protein secretion by the type III secretion system
ND437_06125	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND437_06135	COG1677	Flagellar hook-basal body complex protein FliE
ND437_06150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND437_06155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND437_06200	COG1191	sigma factor activity
ND437_06210	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND437_06215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND437_06220	COG0765	amino acid transport
ND437_06225	COG1126	abc transporter atp-binding protein
ND437_06230	COG0506	proline dehydrogenase activity
ND437_06230	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND437_06230	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND437_06235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND437_06240	COG3710	Transcriptional regulator
ND437_06245	COG0531	amino acid
ND437_06255	COG1113	amino acid transport
ND437_06280	COG2197	response regulator
ND437_06285	COG0322	excinuclease ABC activity
ND437_06290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND437_06310	COG2801	Transposase and inactivated derivatives
ND437_06315	COG0840	transmembrane signaling receptor activity
ND437_06350	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND437_06355	COG2153	protein acetylation
ND437_06390	COG0531	amino acid
ND437_06395	COG0076	glutamate decarboxylase activity
ND437_06410	COG2235	arginine
ND437_06425	COG1757	Na H antiporter
ND437_06430	COG3122	Protein conserved in bacteria
ND437_06445	COG1187	pseudouridine synthase activity
ND437_06450	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND437_06455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND437_06460	COG2723	6-phospho-beta-galactosidase activity
ND437_06465	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND437_06470	COG2169	Transcriptional regulator
ND437_06470	COG1917	Cupin 2, conserved barrel domain protein
ND437_06485	COG1278	Cold shock
ND437_06490	COG1278	Cold shock
ND437_06495	COG1278	Cold shock
ND437_06515	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND437_06535	COG4251	negative regulation of phosphorylation
ND437_06535	COG3706	GGDEF domain
ND437_06535	COG2203	Gaf domain
ND437_06535	COG5001	Diguanylate cyclase
ND437_06545	COG1132	(ABC) transporter
ND437_06565	COG2207	Transcriptional regulator
ND437_06600	COG1113	amino acid transport
ND437_06620	COG1496	oxidoreductase activity
ND437_06625	COG0768	penicillin binding
ND437_06630	COG2226	methyltransferase
ND437_06660	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND437_06670	COG1960	acyl-CoA dehydrogenase activity
ND437_06690	COG1971	Probably functions as a manganese efflux pump
ND437_06695	COG4811	Protein of unknown function (DUF986)
ND437_06700	COG3716	PTS system mannose fructose sorbose family IID component
ND437_06705	COG3715	PTS system
ND437_06710	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND437_06710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND437_06715	COG1253	flavin adenine dinucleotide binding
ND437_06720	COG1760	l-serine dehydratase
ND437_06725	COG0494	nUDIX hydrolase
ND437_06745	COG0513	Belongs to the DEAD box helicase family
ND437_06750	COG3141	response to X-ray
ND437_06755	COG3097	Belongs to the UPF0267 family
ND437_06765	COG1770	oligopeptidase
ND437_06770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND437_06785	COG1528	Iron-storage protein
ND437_06790	COG2372	response to copper ion
ND437_06795	COG1276	copper resistance
ND437_06805	COG4974	Belongs to the 'phage' integrase family
ND437_06850	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ND437_06945	COG4695	Portal protein
ND437_07085	COG3706	GGDEF domain
ND437_07085	COG4251	negative regulation of phosphorylation
ND437_07085	COG5001	Diguanylate cyclase
ND437_07085	COG2203	Gaf domain
ND437_07090	COG3008	intermembrane lipid transfer
ND437_07095	COG2995	paraquat-inducible protein a
ND437_07100	COG1956	GAF domain-containing protein
ND437_07110	COG0793	Belongs to the peptidase S41A family
ND437_07115	COG0501	Belongs to the peptidase M48B family
ND437_07125	COG2814	Major facilitator Superfamily
ND437_07135	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND437_07140	COG1823	symporter activity
ND437_07145	COG1988	membrane-bound metal-dependent
ND437_07150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND437_07160	COG3001	Fructosamine kinase
ND437_07165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND437_07170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND437_07175	COG1121	(ABC) transporter
ND437_07180	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND437_07250	COG0776	regulation of translation
ND437_07320	COG4139	cobalamin transport
ND437_07330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND437_07335	COG0463	Glycosyl transferase, family 2
ND437_07350	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND437_07355	COG2076	Multidrug Resistance protein
ND437_07360	COG2076	Multidrug Resistance protein
ND437_07365	COG0791	NLP P60 protein
ND437_07370	COG0095	Lipoate-protein ligase
ND437_07380	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND437_07385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND437_07390	COG4558	Periplasmic binding protein
ND437_07395	COG3720	iron ion transport
ND437_07400	COG4771	TonB-dependent receptor
ND437_07410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND437_07415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND437_07420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND437_07420	COG0574	Belongs to the PEP-utilizing enzyme family
ND437_07430	COG0628	permease
ND437_07435	COG0247	lactate metabolic process
ND437_07435	COG0277	FAD linked oxidase domain protein
ND437_07440	COG2050	protein possibly involved in aromatic compounds catabolism
ND437_07445	COG0316	Belongs to the HesB IscA family
ND437_07450	COG0719	Fe-S assembly protein
ND437_07455	COG0396	ATPase activity
ND437_07460	COG0719	Fe-S assembly protein
ND437_07470	COG2166	iron-sulfur cluster assembly
ND437_07475	COG1376	ErfK ybiS ycfS ynhG family protein
ND437_07475	COG1388	LysM domain
ND437_07510	COG0307	riboflavin synthase, alpha
ND437_07515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND437_07520	COG2814	Major facilitator Superfamily
ND437_07525	COG0583	DNA-binding transcription factor activity
ND437_07530	COG1609	Transcriptional regulator
ND437_07540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND437_07545	COG0791	NLP P60 protein
ND437_07550	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND437_07565	COG1902	pentaerythritol trinitrate reductase activity
ND437_07570	COG1309	transcriptional regulator
ND437_07575	COG2194	sulfuric ester hydrolase activity
ND437_07580	COG3313	Fe-S protein
ND437_07585	COG4989	oxidoreductase activity
ND437_07595	COG1846	Transcriptional regulator
ND437_07600	COG3133	Outer membrane lipoprotein
ND437_07605	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND437_07650	COG0484	heat shock protein binding
ND437_07660	COG3104	oligopeptide transport
ND437_07670	COG4172	Belongs to the ABC transporter superfamily
ND437_07675	COG4172	Belongs to the ABC transporter superfamily
ND437_07680	COG4171	peptide transport system, permease
ND437_07690	COG4166	transmembrane transport
ND437_07705	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND437_07710	COG1842	Phage shock protein A
ND437_07720	COG1983	PspC domain protein
ND437_07730	COG3106	COG3106 Predicted ATPase
ND437_07735	COG3768	UPF0283 membrane protein
ND437_07740	COG5654	RES domain protein
ND437_07745	COG5642	Protein of unknown function (DUF2384)
ND437_07755	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND437_07760	COG4948	Mandelate Racemase Muconate Lactonizing
ND437_07765	COG2866	Carboxypeptidase
ND437_07770	COG4166	transmembrane transport
ND437_07785	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND437_07785	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND437_07785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND437_07785	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND437_07795	COG1285	pathogenesis
ND437_07800	COG3042	response to heat
ND437_07805	COG3187	Heat shock protein
ND437_07810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND437_07815	COG2911	Protein conserved in bacteria
ND437_07830	COG3784	Protein of unknown function (DUF1318)
ND437_07835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND437_07840	COG1643	Atp-dependent helicase
ND437_07845	COG3591	Belongs to the peptidase S1B family
ND437_07855	COG1881	PFAM PEBP family protein
ND437_07860	COG2207	Transcriptional regulator
ND437_07875	COG2205	protein histidine kinase activity
ND437_07880	COG0745	RESPONSE REGULATOR receiver
ND437_07890	COG0531	amino acid
ND437_07900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND437_07905	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND437_07910	COG3623	hexulose-6-phosphate isomerase
ND437_07915	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND437_07945	COG0589	response to stress
ND437_07950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND437_07955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND437_07960	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND437_07970	COG1011	Hydrolase
ND437_08010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND437_08030	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND437_08035	COG4221	oxidoreductase activity
ND437_08040	COG1742	UPF0060 membrane protein
ND437_08060	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND437_08065	COG1940	carbohydrate kinase activity
ND437_08075	COG0114	fumarate hydratase activity
ND437_08080	COG1482	cell wall glycoprotein biosynthetic process
ND437_08085	COG5339	Protein conserved in bacteria
ND437_08090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND437_08095	COG0385	Bile acid
ND437_08100	COG0673	inositol 2-dehydrogenase activity
ND437_08110	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND437_08120	COG4657	Part of a membrane complex involved in electron transport
ND437_08135	COG3708	Transcriptional regulator
ND437_08135	COG2207	Transcriptional regulator
ND437_08145	COG4659	FMN binding
ND437_08155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND437_08160	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND437_08165	COG5002	protein histidine kinase activity
ND437_08165	COG3447	MASE1 domain protein
ND437_08165	COG5001	Diguanylate cyclase
ND437_08170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND437_08180	COG0023	Translation Initiation Factor
ND437_08200	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND437_08205	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND437_08210	COG0671	phosphoesterase, PA-phosphatase related
ND437_08220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND437_08240	COG0583	DNA-binding transcription factor activity
ND437_08255	COG0616	signal peptide processing
ND437_08260	COG1028	Short-chain dehydrogenase reductase Sdr
ND437_08270	COG1187	pseudouridine synthase activity
ND437_08275	COG0009	L-threonylcarbamoyladenylate synthase
ND437_08280	COG0613	PHP domain protein
ND437_08290	COG0512	Glutamine amidotransferase of anthranilate synthase
ND437_08300	COG0134	indole-3-glycerol-phosphate synthase activity
ND437_08300	COG0135	phosphoribosylanthranilate isomerase activity
ND437_08305	COG0133	tryptophan synthase activity
ND437_08320	COG3047	cAMP biosynthetic process
ND437_08325	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND437_08350	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND437_08385	COG3710	Transcriptional regulator
ND437_08400	COG2350	Protein conserved in bacteria
ND437_08420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND437_08425	COG3099	Belongs to the UPF0263 family
ND437_08440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND437_08455	COG4166	transmembrane transport
ND437_08460	COG2095	MarC family integral membrane protein
ND437_08470	COG1454	alcohol dehydrogenase
ND437_08470	COG1012	belongs to the aldehyde dehydrogenase family
ND437_08490	COG0745	RESPONSE REGULATOR receiver
ND437_08495	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND437_08505	COG0788	formyltetrahydrofolate deformylase activity
ND437_08530	COG0708	Exodeoxyribonuclease III
ND437_08535	COG0494	nUDIX hydrolase
ND437_08545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND437_08555	COG0778	Nitroreductase
ND437_08560	COG0616	signal peptide processing
ND437_08565	COG0252	asparaginase activity
ND437_08570	COG1335	isochorismatase
ND437_08575	COG3139	Protein of unknown function (DUF1315)
ND437_08580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND437_08595	COG2194	sulfuric ester hydrolase activity
ND437_08600	COG3713	MltA-interacting MipA family protein
ND437_08605	COG2766	serine protein kinase
ND437_08610	COG2718	Belongs to the UPF0229 family
ND437_08630	COG2202	Pas domain
ND437_08630	COG2200	EAL domain
ND437_08630	COG2199	diguanylate cyclase activity
ND437_08640	COG2814	Major facilitator Superfamily
ND437_08645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND437_08650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND437_08655	COG2719	SpoVR family
ND437_08665	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND437_08685	COG2983	Belongs to the UPF0260 family
ND437_08690	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND437_08695	COG3100	YcgL domain-containing protein
ND437_08700	COG0850	regulation of cytokinetic process
ND437_08705	COG2894	cell division
ND437_08710	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND437_08715	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND437_08720	COG0318	PFAM AMP-dependent synthetase and ligase
ND437_08725	COG3065	identical protein binding
ND437_08730	COG1214	PFAM Peptidase M22, glycoprotease
ND437_08735	COG1199	ATP-dependent helicase activity
ND437_08740	COG0251	oxidation-reduction process
ND437_08745	COG2076	Multidrug Resistance protein
ND437_08755	COG0800	Aldolase
ND437_08760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND437_08765	COG1737	Transcriptional regulator
ND437_08770	COG0469	pyruvate kinase activity
ND437_08775	COG1560	Kdo2-lipid A biosynthetic process
ND437_08780	COG0739	heme binding
ND437_08785	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND437_08790	COG1121	(ABC) transporter
ND437_08795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND437_08800	COG3104	oligopeptide transport
ND437_08805	COG2255	four-way junction helicase activity
ND437_08815	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND437_08825	COG0494	nUDIX hydrolase
ND437_08830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND437_08840	COG1801	Protein of unknown function DUF72
ND437_08845	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND437_08860	COG3142	Participates in the control of copper homeostasis
ND437_08865	COG3102	Protein conserved in bacteria
ND437_08890	COG0728	peptidoglycan biosynthetic process
ND437_08895	COG0673	inositol 2-dehydrogenase activity
ND437_08905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND437_08925	COG3381	protein complex oligomerization
ND437_08935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND437_08960	COG3706	GGDEF domain
ND437_08965	COG0659	secondary active sulfate transmembrane transporter activity
ND437_08970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND437_08985	COG2890	protein-(glutamine-N5) methyltransferase activity
ND437_08990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND437_08995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND437_09000	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND437_09010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND437_09020	COG0193	aminoacyl-tRNA hydrolase activity
ND437_09030	COG0012	GTP binding
ND437_09050	COG0309	Hydrogenase expression formation protein (HypE)
ND437_09055	COG0409	Hydrogenase expression formation protein
ND437_09060	COG0298	carbon dioxide binding
ND437_09065	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND437_09070	COG0375	protein maturation
ND437_09080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND437_09085	COG0651	ATP synthesis coupled electron transport
ND437_09090	COG0650	Formate hydrogenlyase subunit 4
ND437_09095	COG3261	NADH dehydrogenase
ND437_09095	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND437_09100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND437_09105	COG3260	NADH ubiquinone oxidoreductase 20
ND437_09115	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND437_09120	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND437_09125	COG3383	formate dehydrogenase (NAD+) activity
ND437_09130	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND437_09135	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND437_09155	COG0402	S-adenosylhomocysteine deaminase activity
ND437_09165	COG1228	amidohydrolase
ND437_09185	COG3724	N-succinylarginine dihydrolase activity
ND437_09195	COG3138	arginine N-succinyltransferase
ND437_09200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND437_09205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND437_09210	COG1271	oxidase subunit
ND437_09215	COG1294	oxidase, subunit
ND437_09225	COG3850	Histidine kinase
ND437_09230	COG2375	cellular response to nickel ion
ND437_09235	COG0387	Pfam Sodium calcium exchanger
ND437_09240	COG1702	phosphate starvation-inducible protein PhoH
ND437_09245	COG4977	sequence-specific DNA binding
ND437_09285	COG0471	metal ion transport
ND437_09290	COG3290	protein histidine kinase activity
ND437_09295	COG4565	transcriptional regulatory protein
ND437_09300	COG3493	citrate carrier protein
ND437_09310	COG0339	signal peptide processing
ND437_09320	COG2723	6-phospho-beta-galactosidase activity
ND437_09325	COG3916	Acyl-homoserine-lactone synthase
ND437_09330	COG2771	luxR family
ND437_09455	COG4626	Terminase
ND437_09455	COG1802	Transcriptional regulator
ND437_09470	COG3646	Phage regulatory protein
ND437_09480	COG3179	chitinase
ND437_09515	COG1403	HNH endonuclease
ND437_09540	COG1802	Transcriptional regulator
ND437_09540	COG4626	Terminase
ND437_09590	COG5532	Uncharacterized conserved protein (DUF2303)
ND437_09595	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND437_09615	COG0582	viral genome integration into host DNA
ND437_09620	COG0538	isocitrate dehydrogenase activity
ND437_09625	COG1187	pseudouridine synthase activity
ND437_09635	COG0482	sulfurtransferase activity
ND437_09645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND437_09655	COG0745	RESPONSE REGULATOR receiver
ND437_09660	COG2205	protein histidine kinase activity
ND437_09665	COG2850	peptidyl-arginine hydroxylation
ND437_09685	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND437_09695	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND437_09700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND437_09705	COG3134	Outer membrane lipoprotein
ND437_09710	COG1252	NADH dehydrogenase
ND437_09715	COG3150	esterase
ND437_09730	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND437_09735	COG5633	Lipoprotein
ND437_09740	COG0537	adenosine 5'-monophosphoramidase activity
ND437_09745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND437_09745	COG1263	PTS System
ND437_09750	COG0084	hydrolase, TatD family'
ND437_09755	COG0470	DNA polymerase III
ND437_09760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND437_09765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND437_09770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND437_09775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND437_09780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND437_09790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND437_09795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND437_09805	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND437_09810	COG1399	metal-binding, possibly nucleic acid-binding protein
ND437_09815	COG0424	maF-like protein
ND437_09820	COG0564	pseudouridine synthase activity
ND437_09825	COG1530	ribonuclease E activity
ND437_09835	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND437_09840	COG0418	dihydroorotase activity
ND437_09865	COG0628	permease
ND437_09875	COG1560	Kdo2-lipid A biosynthetic process
ND437_09900	COG2943	transferase activity, transferring hexosyl groups
ND437_09905	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND437_09925	COG0288	reversible hydration of carbon dioxide
ND437_09935	COG2920	part of a sulfur-relay system
ND437_09940	COG1254	Belongs to the acylphosphatase family
ND437_09945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND437_09950	COG3785	DNA binding
ND437_09955	COG1832	CoA-binding protein
ND437_09965	COG1803	Methylglyoxal synthase
ND437_09970	COG0210	DNA helicase
ND437_09975	COG3304	Inner membrane component domain
ND437_09980	COG1289	transmembrane transporter activity
ND437_09985	COG3070	regulator of competence-specific genes
ND437_09990	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND437_10000	COG3120	sequence-specific DNA binding
ND437_10005	COG1067	ATP-dependent peptidase activity
ND437_10010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND437_10015	COG3130	regulation of translation
ND437_10020	COG3009	Protein conserved in bacteria
ND437_10025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND437_10025	COG3008	intermembrane lipid transfer
ND437_10030	COG2995	paraquat-inducible protein a
ND437_10035	COG0488	(ABC) transporter
ND437_10040	COG0116	Belongs to the methyltransferase superfamily
ND437_10040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND437_10045	COG0633	Ferredoxin
ND437_10045	COG3217	Mosc domain protein beta barrel domain protein
ND437_10055	COG0167	dihydroorotate dehydrogenase activity
ND437_10060	COG0308	aminopeptidase N
ND437_10065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND437_10080	COG1448	Aminotransferase
ND437_10085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND437_10090	COG3108	Peptidase M15
ND437_10095	COG2989	Protein conserved in bacteria
ND437_10100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND437_10110	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND437_10115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND437_10120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND437_10125	COG3173	Aminoglycoside phosphotransferase
ND437_10130	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND437_10135	COG2835	tetraacyldisaccharide 4'-kinase activity
ND437_10140	COG1278	Cold shock
ND437_10150	COG5383	Protein conserved in bacteria
ND437_10155	COG1663	tetraacyldisaccharide 4'-kinase activity
ND437_10165	COG2333	competence protein COMEC
ND437_10165	COG0658	competence protein
ND437_10175	COG0539	negative regulation of cytoplasmic translation
ND437_10185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND437_10195	COG0252	asparaginase activity
ND437_10200	COG1944	ATP diphosphatase activity
ND437_10205	COG2116	formate transmembrane transporter activity
ND437_10210	COG1882	Formate acetyltransferase
ND437_10215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND437_10220	COG2814	Major facilitator Superfamily
ND437_10225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND437_10230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND437_10235	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND437_10240	COG1674	ftsk spoiiie
ND437_10240	COG3107	peptidoglycan biosynthetic process
ND437_10245	COG1522	sequence-specific DNA binding
ND437_10250	COG0492	ferredoxin-NADP+ reductase activity
ND437_10260	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND437_10270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND437_10275	COG0542	response to heat
ND437_10280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND437_10285	COG1278	Cold shock
ND437_10295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND437_10300	COG2990	Protein conserved in bacteria
ND437_10305	COG3593	DNA synthesis involved in DNA repair
ND437_10310	COG2431	L-lysine efflux transmembrane transporter activity
ND437_10315	COG1151	hydroxylamine reductase activity
ND437_10320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND437_10325	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND437_10330	COG0702	epimerase
ND437_10335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND437_10340	COG0393	Putative heavy-metal-binding
ND437_10350	COG1126	abc transporter atp-binding protein
ND437_10355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND437_10360	COG4215	(ABC) transporter
ND437_10365	COG4160	amino acid transport
ND437_10370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND437_10385	COG1177	transmembrane transport
ND437_10390	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND437_10395	COG3842	ATPase activity
ND437_10400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND437_10420	COG0569	domain protein
ND437_10420	COG2985	domain, Protein
ND437_10430	COG0671	phosphoesterase, PA-phosphatase related
ND437_10440	COG1349	DNA-binding transcription factor activity
ND437_10445	COG0814	amino acid
ND437_10450	COG1760	l-serine dehydratase
ND437_10455	COG1686	Belongs to the peptidase S11 family
ND437_10465	COG0626	cystathionine gamma-synthase activity
ND437_10480	COG0625	glutathione transferase activity
ND437_10485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND437_10500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND437_10505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND437_10520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND437_10530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND437_10530	COG0140	phosphoribosyl-ATP diphosphatase activity
ND437_10540	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND437_10545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND437_10550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND437_10555	COG1253	flavin adenine dinucleotide binding
ND437_10560	COG3069	C4-dicarboxylate transmembrane transporter activity
ND437_10565	COG2982	Protein involved in outer membrane biogenesis
ND437_10570	COG0717	Belongs to the dCTP deaminase family
ND437_10575	COG0572	uridine kinase
ND437_10580	COG0489	protein tyrosine kinase activity
ND437_10585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND437_10585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND437_10595	COG1380	Effector of murein hydrolase LrgA
ND437_10600	COG1346	cytolysis
ND437_10610	COG0583	DNA-binding transcription factor activity
ND437_10620	COG0281	malic enzyme
ND437_10625	COG2949	membrane
ND437_10650	COG2311	Membrane
ND437_10655	COG0302	gtp cyclohydrolase
ND437_10660	COG0477	Major facilitator Superfamily
ND437_10665	COG0583	DNA-binding transcription factor activity
ND437_10685	COG0303	'Molybdopterin
ND437_10690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND437_10695	COG0488	(ABC) transporter
ND437_10700	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND437_10705	COG2239	Acts as a magnesium transporter
ND437_10710	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND437_10730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND437_10735	COG0765	amino acid transport
ND437_10740	COG1126	abc transporter atp-binding protein
ND437_10745	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND437_10750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND437_10765	COG0697	spore germination
ND437_10775	COG1982	Orn Lys Arg decarboxylase major
ND437_10780	COG0531	amino acid
ND437_10785	COG1174	glycine betaine transport
ND437_10790	COG1125	glycine betaine transport
ND437_10795	COG1174	glycine betaine transport
ND437_10800	COG1732	Glycine betaine
ND437_10805	COG2897	thiosulfate sulfurtransferase activity
ND437_10810	COG4807	Protein conserved in bacteria
ND437_10815	COG3639	organic phosphonate transmembrane transporter activity
ND437_10825	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND437_10835	COG2261	transglycosylase associated protein
ND437_10855	COG0277	FAD linked oxidase domain protein
ND437_10860	COG1686	Belongs to the peptidase S11 family
ND437_10870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND437_10875	COG0513	Belongs to the DEAD box helicase family
ND437_10880	COG1309	transcriptional regulator
ND437_10885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND437_10890	COG1131	(ABC) transporter
ND437_10895	COG0842	Transport permease protein
ND437_10900	COG0842	Transport permease protein
ND437_10905	COG0670	Belongs to the BI1 family
ND437_10910	COG0314	molybdopterin synthase activity
ND437_10915	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND437_10925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND437_10930	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND437_10935	COG1120	ATPase activity
ND437_10940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND437_10955	COG4628	conserved protein (DUF2132)
ND437_10960	COG0556	nucleotide-excision repair
ND437_10975	COG2226	methyltransferase
ND437_10980	COG0156	8-amino-7-oxononanoate synthase activity
ND437_10995	COG2706	6-phosphogluconolactonase activity
ND437_11000	COG0561	phosphatase activity
ND437_11010	COG4149	molybdate abc transporter
ND437_11015	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND437_11025	COG3585	molybdate ion transport
ND437_11025	COG2005	Transcriptional regulator
ND437_11040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND437_11045	COG1085	galactose-1-phosphate uridylyltransferase
ND437_11055	COG2017	converts alpha-aldose to the beta-anomer
ND437_11065	COG0588	phosphoglycerate mutase activity
ND437_11070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND437_11080	COG2205	protein histidine kinase activity
ND437_11080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND437_11090	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND437_11115	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND437_11120	COG2885	chlorophyll binding
ND437_11125	COG0823	Involved in the tonB-independent uptake of proteins
ND437_11130	COG3064	Membrane
ND437_11130	COG3064	Membrane
ND437_11135	COG0848	biopolymer transport protein
ND437_11140	COG0811	peptide transport
ND437_11145	COG0824	Thioesterase
ND437_11150	COG3790	cyd operon protein YbgE
ND437_11155	COG4890	Cyd operon protein YbgT
ND437_11160	COG1294	oxidase, subunit
ND437_11165	COG1271	oxidase subunit
ND437_11170	COG0737	Belongs to the 5'-nucleotidase family
ND437_11175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND437_11180	COG0045	succinate-CoA ligase (ADP-forming) activity
ND437_11185	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND437_11190	COG0567	Dehydrogenase, E1 component
ND437_11195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND437_11200	COG1053	succinate dehydrogenase
ND437_11205	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND437_11240	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND437_11245	COG1984	allophanate hydrolase subunit 2
ND437_11250	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND437_11255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND437_11260	COG5212	phosphodiesterase
ND437_11265	COG0415	Belongs to the DNA photolyase family
ND437_11270	COG3272	Protein of unknown function (DUF1722)
ND437_11290	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND437_11295	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND437_11300	COG2205	protein histidine kinase activity
ND437_11305	COG0745	RESPONSE REGULATOR receiver
ND437_11315	COG0033	Phosphoglucomutase
ND437_11320	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND437_11325	COG0596	Alpha beta hydrolase
ND437_11335	COG0840	transmembrane signaling receptor activity
ND437_11345	COG0735	belongs to the Fur family
ND437_11370	COG2190	(PTS) system
ND437_11370	COG1263	PTS System
ND437_11370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND437_11380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND437_11385	COG1940	carbohydrate kinase activity
ND437_11385	COG1846	Transcriptional regulator
ND437_11390	COG0647	UMP catabolic process
ND437_11395	COG0367	asparagine synthase
ND437_11430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND437_11435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND437_11440	COG1702	phosphate starvation-inducible protein PhoH
ND437_11445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND437_11450	COG4535	Mg2 and Co2 transporter CorC
ND437_11455	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND437_11465	COG0765	amino acid transport
ND437_11470	COG0765	amino acid transport
ND437_11475	COG1126	abc transporter atp-binding protein
ND437_11480	COG2888	peptidyl-tyrosine sulfation
ND437_11490	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND437_11495	COG1466	dna polymerase III delta subunit
ND437_11500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND437_11505	COG0799	negative regulation of ribosome biogenesis
ND437_11510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND437_11515	COG0768	penicillin binding
ND437_11520	COG0772	Belongs to the SEDS family
ND437_11525	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND437_11530	COG1686	Belongs to the peptidase S11 family
ND437_11535	COG2921	Belongs to the UPF0250 family
ND437_11545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND437_11555	COG3706	GGDEF domain
ND437_11575	COG1278	Cold shock
ND437_11580	COG2197	response regulator
ND437_11615	COG1309	transcriptional regulator
ND437_11630	COG3250	beta-galactosidase activity
ND437_11650	COG1215	transferase activity, transferring glycosyl groups
ND437_11660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND437_11690	COG3038	cytochrome b561
ND437_11715	COG1022	Amp-dependent synthetase and ligase
ND437_11725	COG1393	Belongs to the ArsC family
ND437_11730	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND437_11790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND437_11795	COG2501	S4 domain
ND437_11825	COG3121	Chaperone
ND437_11830	COG3188	usher protein
ND437_11855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND437_11860	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND437_11865	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND437_11870	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND437_11875	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND437_11880	COG4181	ATPase activity
ND437_11885	COG2755	lipolytic protein G-D-S-L family
ND437_11890	COG0300	oxidoreductase activity
ND437_11895	COG3118	belongs to the thioredoxin family
ND437_11900	COG0330	HflC and HflK could
ND437_11905	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND437_11910	COG0789	Transcriptional regulator
ND437_11915	COG2217	Heavy metal translocating P-type atpase
ND437_11920	COG3735	TraB family
ND437_11925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND437_11935	COG1086	Polysaccharide biosynthesis protein
ND437_11965	COG0500	methyltransferase
ND437_11980	COG0737	Belongs to the 5'-nucleotidase family
ND437_11985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND437_11985	COG4651	solute:proton antiporter activity
ND437_11990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND437_11995	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND437_12010	COG0326	Molecular chaperone. Has ATPase activity
ND437_12015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND437_12055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND437_12060	COG2832	Protein of unknown function (DUF454)
ND437_12075	COG3264	Mechanosensitive ion channel
ND437_12075	COG1196	nuclear chromosome segregation
ND437_12080	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND437_12085	COG1309	transcriptional regulator
ND437_12090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND437_12095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND437_12100	COG0254	rRNA binding
ND437_12105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND437_12130	COG3695	enzyme binding
ND437_12135	COG1946	Acyl-CoA thioesterase
ND437_12140	COG0004	ammonium transporteR
ND437_12145	COG0347	Belongs to the P(II) protein family
ND437_12150	COG1132	(ABC) transporter
ND437_12155	COG1132	(ABC) transporter
ND437_12160	COG1522	sequence-specific DNA binding
ND437_12175	COG4533	DNA binding
ND437_12180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND437_12185	COG0824	Thioesterase
ND437_12190	COG1555	photosystem II stabilization
ND437_12195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND437_12200	COG0776	regulation of translation
ND437_12205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND437_12210	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND437_12215	COG0740	serine-type endopeptidase activity
ND437_12225	COG0271	Belongs to the BolA IbaG family
ND437_12230	COG3056	Lipoprotein
ND437_12235	COG2223	nitrite transmembrane transporter activity
ND437_12245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND437_12250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND437_12255	COG1845	cytochrome c oxidase, subunit III
ND437_12260	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND437_12270	COG2814	Major facilitator Superfamily
ND437_12275	COG1666	GTP binding
ND437_12280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND437_12285	COG0693	protein deglycase activity
ND437_12320	COG0142	geranyltranstransferase activity
ND437_12325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND437_12330	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND437_12335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND437_12345	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND437_12350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND437_12350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND437_12355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND437_12360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND437_12365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND437_12370	COG1862	Preprotein translocase
ND437_12385	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND437_12390	COG0450	alkyl hydroperoxide reductase
ND437_12395	COG0300	oxidoreductase activity
ND437_12400	COG0366	Alpha amylase catalytic
ND437_12405	COG1113	amino acid transport
ND437_12420	COG5002	protein histidine kinase activity
ND437_12425	COG0745	RESPONSE REGULATOR receiver
ND437_12430	COG0420	3'-5' exonuclease activity
ND437_12435	COG0419	ATPase involved in DNA repair
ND437_12440	COG1940	carbohydrate kinase activity
ND437_12445	COG2974	May be involved in recombination
ND437_12455	COG4126	flavin adenine dinucleotide binding
ND437_12475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND437_12510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND437_12515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ND437_12525	COG1073	alpha beta
ND437_12530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND437_12535	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND437_12540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND437_12550	COG2991	Protein conserved in bacteria
ND437_12555	COG1477	protein flavinylation
ND437_12565	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND437_12570	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND437_12575	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND437_12580	COG1805	sodium ion transport
ND437_12590	COG3034	peptidoglycan biosynthetic process
ND437_12595	COG0121	glutamine amidotransferase
ND437_12600	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND437_12605	COG1960	acyl-CoA dehydrogenase activity
ND437_12615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND437_12625	COG2226	methyltransferase
ND437_12635	COG1388	LysM domain
ND437_12635	COG0741	lytic transglycosylase activity
ND437_12640	COG3021	interspecies interaction between organisms
ND437_12670	COG0542	response to heat
ND437_12675	COG1496	oxidoreductase activity
ND437_12680	COG0564	pseudouridine synthase activity
ND437_12685	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND437_12690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND437_12700	COG1605	Chorismate mutase
ND437_12700	COG0077	Prephenate dehydratase
ND437_12705	COG1605	Chorismate mutase
ND437_12705	COG0287	Prephenate dehydrogenase
ND437_12710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND437_12715	COG3279	Response regulator of the LytR AlgR family
ND437_12720	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND437_12725	COG3137	Salt-induced outer membrane protein
ND437_12730	COG0335	large ribosomal subunit rRNA binding
ND437_12735	COG0336	Belongs to the RNA methyltransferase TrmD family
ND437_12740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND437_12750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND437_12755	COG4137	Cytochrome C assembly protein
ND437_12760	COG4536	flavin adenine dinucleotide binding
ND437_12765	COG1854	S-ribosylhomocysteine lyase activity
ND437_12770	COG2918	glutathione biosynthetic process
ND437_12775	COG1238	metal cluster binding
ND437_12780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND437_12805	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND437_12810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND437_12815	COG2137	regulation of response to DNA damage stimulus
ND437_12820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND437_12835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND437_12835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND437_12860	COG3031	protein transport across the cell outer membrane
ND437_12870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND437_12915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ND437_12925	COG3397	chitin binding
ND437_12945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND437_13075	COG0741	lytic transglycosylase activity
ND437_13095	COG2205	protein histidine kinase activity
ND437_13095	COG0784	Response regulator, receiver
ND437_13160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND437_13165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND437_13170	COG1388	LysM domain
ND437_13170	COG4942	peptidase
ND437_13180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND437_13185	COG0585	pseudouridine synthase activity
ND437_13190	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND437_13200	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND437_13210	COG0529	Catalyzes the synthesis of activated sulfate
ND437_13215	COG2895	sulfate adenylyltransferase (ATP) activity
ND437_13220	COG0175	sulfate reduction
ND437_13225	COG1648	precorrin-2 dehydrogenase activity
ND437_13225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND437_13230	COG2234	aminopeptidase activity
ND437_13245	COG0175	sulfate reduction
ND437_13255	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND437_13260	COG0720	synthase
ND437_13265	COG0602	queuosine metabolic process
ND437_13275	COG0504	CTP synthase activity
ND437_13280	COG3956	TIGRFAM MazG family protein
ND437_13285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND437_13290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND437_13300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND437_13305	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND437_13310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND437_13320	COG2860	membrane
ND437_13325	COG0316	Belongs to the HesB IscA family
ND437_13335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND437_13340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND437_13345	COG1643	Atp-dependent helicase
ND437_13350	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND437_13355	COG1489	DNA binding
ND437_13370	COG0617	tRNA 3'-terminal CCA addition
ND437_13375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND437_13380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND437_13385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND437_13390	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND437_13395	COG0726	polysaccharide deacetylase
ND437_13400	COG0842	Transport permease protein
ND437_13405	COG1131	(ABC) transporter
ND437_13410	COG0288	reversible hydration of carbon dioxide
ND437_13420	COG2132	Multicopper oxidase
ND437_13430	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND437_13445	COG3112	Uncharacterised protein family (UPF0231)
ND437_13450	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND437_13460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND437_13465	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND437_13470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND437_13475	COG2186	Transcriptional regulator
ND437_13480	COG1113	amino acid transport
ND437_13485	COG3725	Membrane protein required for beta-lactamase induction
ND437_13500	COG4969	Belongs to the N-Me-Phe pilin family
ND437_13505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND437_13510	COG1459	type II secretion system
ND437_13515	COG0516	GMP reductase activity
ND437_13535	COG0494	nUDIX hydrolase
ND437_13560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND437_13565	COG0849	cell division
ND437_13570	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND437_13580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND437_13585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND437_13590	COG0772	Belongs to the SEDS family
ND437_13605	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND437_13610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND437_13615	COG0768	penicillin binding
ND437_13620	COG3116	cell division
ND437_13625	COG0275	rRNA processing
ND437_13640	COG0675	Transposase, IS605 OrfB family
ND437_13660	COG0028	Belongs to the TPP enzyme family
ND437_13665	COG1022	Amp-dependent synthetase and ligase
ND437_13680	COG0473	3-isopropylmalate dehydrogenase activity
ND437_13685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND437_13695	COG2814	Major facilitator Superfamily
ND437_13710	COG4143	(ABC) transporter
ND437_13715	COG1178	ABC-type Fe3 transport system permease component
ND437_13725	COG0586	Pfam SNARE associated Golgi protein
ND437_13730	COG0417	DNA replication proofreading
ND437_13735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND437_13740	COG0564	pseudouridine synthase activity
ND437_13750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND437_13760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND437_13765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND437_13770	COG2967	ApaG domain
ND437_13795	COG2966	Psort location CytoplasmicMembrane, score
ND437_13805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND437_13820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND437_13825	COG1047	Peptidyl-prolyl cis-trans
ND437_13830	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND437_13840	COG0196	riboflavin kinase activity
ND437_13850	COG0583	DNA-binding transcription factor activity
ND437_13855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND437_13865	COG0443	Heat shock 70 kDa protein
ND437_13870	COG1584	GPR1 FUN34 yaaH family protein
ND437_13880	COG0477	Major facilitator Superfamily
ND437_13885	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND437_13890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND437_13925	COG0745	RESPONSE REGULATOR receiver
ND437_13930	COG3045	CreA protein
ND437_13935	COG2207	Transcriptional regulator
ND437_13935	COG3708	Transcriptional regulator
ND437_13940	COG0406	alpha-ribazole phosphatase activity
ND437_13945	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND437_13950	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND437_13955	COG0741	lytic transglycosylase activity
ND437_13975	COG0488	(ABC) transporter
ND437_13990	COG0560	Phosphoserine phosphatase
ND437_13995	COG3726	membrane protein affecting hemolysin expression
ND437_14005	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND437_14020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND437_14025	COG0084	hydrolase, TatD family'
ND437_14030	COG4667	esterase of the alpha-beta hydrolase superfamily
ND437_14040	COG2823	Periplasmic or secreted lipoprotein
ND437_14055	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND437_14095	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND437_14095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND437_14095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND437_14100	COG1461	Dihydroxyacetone kinase
ND437_14105	COG2376	Dihydroxyacetone kinase
ND437_14115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND437_14120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND437_14135	COG0859	PFAM glycosyl transferase family 9
ND437_14160	COG3119	arylsulfatase activity
ND437_14165	COG0641	radical SAM
ND437_14175	COG1028	Short-chain dehydrogenase reductase Sdr
ND437_14185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND437_14195	COG3716	PTS system mannose fructose sorbose family IID component
ND437_14200	COG3715	PTS system
ND437_14205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND437_14210	COG2222	sugar isomerase
ND437_14220	COG1349	DNA-binding transcription factor activity
ND437_14225	COG3119	arylsulfatase activity
ND437_14245	COG5492	domain, Protein
ND437_14335	COG3077	Addiction module antitoxin, RelB DinJ family
ND437_14360	COG0795	lipopolysaccharide-transporting ATPase activity
ND437_14365	COG0795	lipopolysaccharide-transporting ATPase activity
ND437_14370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND437_14375	COG2927	DNA polymerase III (CHI subunit)
ND437_14390	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND437_14410	COG3624	Phosphonate C-P lyase system protein PhnG
ND437_14415	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND437_14420	COG3626	phosphonate metabolism
ND437_14425	COG3627	carbon phosphorus lyase activity
ND437_14430	COG4107	phosphonate C-P lyase system protein PhnK
ND437_14435	COG4778	phosphonate C-P lyase system protein PhnL
ND437_14440	COG3454	Phosphonate metabolism
ND437_14445	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND437_14450	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND437_14455	COG0702	epimerase
ND437_14460	COG3787	Belongs to the UPF0306 family
ND437_14470	COG1982	Orn Lys Arg decarboxylase major
ND437_14475	COG0531	amino acid
ND437_14480	COG2827	Endonuclease containing a URI domain
ND437_14485	COG3153	acetyltransferase
ND437_14490	COG3154	lipid carrier protein
ND437_14495	COG0826	peptidase U32
ND437_14500	COG0826	peptidase U32
ND437_14510	COG0814	amino acid
ND437_14515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND437_14520	COG0513	Belongs to the DEAD box helicase family
ND437_14530	COG1185	polyribonucleotide nucleotidyltransferase activity
ND437_14545	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND437_14555	COG0195	Participates in both transcription termination and antitermination
ND437_14575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND437_14580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND437_14585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND437_14595	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND437_14600	COG1534	Rna-binding protein
ND437_14610	COG2027	D-alanyl-D-alanine carboxypeptidase
ND437_14615	COG0745	RESPONSE REGULATOR receiver
ND437_14620	COG0642	Histidine kinase
ND437_14625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND437_14630	COG0697	spore germination
ND437_14645	COG0142	geranyltranstransferase activity
ND437_14660	COG3423	Transcriptional regulator
ND437_14675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND437_14685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND437_14690	COG2105	PFAM AIG2 family protein
ND437_14695	COG2911	Protein conserved in bacteria
ND437_14700	COG0729	surface antigen
ND437_14705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND437_14710	COG1253	flavin adenine dinucleotide binding
ND437_14720	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND437_14725	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND437_14730	COG0737	Belongs to the 5'-nucleotidase family
ND437_14740	COG0545	Peptidyl-prolyl cis-trans isomerase
ND437_14745	COG3061	Opacity-associated protein A
ND437_14750	COG0359	binds to the 23S rRNA
ND437_14755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND437_14760	COG2965	DNA replication, synthesis of RNA primer
ND437_14765	COG0360	Binds together with S18 to 16S ribosomal RNA
ND437_14775	COG1073	alpha beta
ND437_14795	COG3188	usher protein
ND437_14800	COG3121	Chaperone
ND437_14820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND437_14825	COG0557	exoribonuclease II activity
ND437_14830	COG1959	2 iron, 2 sulfur cluster binding
ND437_14835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND437_14840	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND437_14845	COG0330	HflC and HflK could
ND437_14850	COG0330	HflC and HflK could
ND437_14855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND437_14865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND437_14875	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND437_14880	COG0802	atpase or kinase
ND437_14885	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND437_14885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND437_14890	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND437_14910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND437_14915	COG1162	GTPase activity
ND437_14920	COG0688	phosphatidylethanolamine metabolic process
ND437_14925	COG1511	domain protein
ND437_14925	COG3264	Mechanosensitive ion channel
ND437_14930	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND437_14935	COG1053	succinate dehydrogenase
ND437_14940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND437_14945	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND437_14950	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND437_14970	COG3188	usher protein
ND437_14990	COG3397	chitin binding
ND437_15000	COG1509	lysine 2,3-aminomutase activity
ND437_15030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND437_15040	COG4232	protein-disulfide reductase activity
ND437_15045	COG1309	transcriptional regulator
ND437_15055	COG1301	dicarboxylic acid transport
ND437_15060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND437_15065	COG3162	membrane
ND437_15070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND437_15095	COG0138	bifunctional purine biosynthesis protein purh
ND437_15100	COG0151	Belongs to the GarS family
ND437_15120	COG1515	deoxyribonuclease V activity
ND437_15125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND437_15130	COG2816	NAD+ diphosphatase activity
ND437_15135	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND437_15150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND437_15155	COG2104	thiamine diphosphate biosynthetic process
ND437_15160	COG2022	thiamine diphosphate biosynthetic process
ND437_15170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND437_15175	COG0085	RNA polymerase activity
ND437_15180	COG0222	ribosome binding
ND437_15185	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND437_15195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND437_15200	COG0250	Participates in transcription elongation, termination and antitermination
ND437_15245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND437_15270	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND437_15275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND437_15280	COG1739	Uncharacterized protein family UPF0029
ND437_15290	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND437_15290	COG1024	Enoyl-CoA hydratase
ND437_15300	COG0543	2 iron, 2 sulfur cluster binding
ND437_15315	COG0250	Participates in transcription elongation, termination and antitermination
ND437_15330	COG0805	protein transport
ND437_15335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND437_15340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND437_15345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND437_15350	COG3165	ubiquinone biosynthetic process from chorismate
ND437_15355	COG2226	methyltransferase
ND437_15360	COG1322	Protein conserved in bacteria
ND437_15365	COG0586	Pfam SNARE associated Golgi protein
ND437_15370	COG1966	Carbon starvation protein
ND437_15385	COG0412	Dienelactone hydrolase
ND437_15390	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND437_15395	COG0583	DNA-binding transcription factor activity
ND437_15400	COG0697	spore germination
ND437_15410	COG0584	glycerophosphoryl diester phosphodiesterase
ND437_15420	COG0395	ABC-type sugar transport system, permease component
ND437_15425	COG1175	transmembrane transport
ND437_15430	COG1653	transport
ND437_15465	COG0410	ABC transporter
ND437_15475	COG4177	L-phenylalanine transmembrane transporter activity
ND437_15495	COG1929	Belongs to the glycerate kinase type-1 family
ND437_15500	COG2610	gluconate transmembrane transporter activity
ND437_15505	COG3835	regulator
ND437_15515	COG2177	Part of the ABC transporter FtsEX involved in
ND437_15520	COG2884	Cell division ATP-binding protein ftsE
ND437_15525	COG0552	protein localization to endoplasmic reticulum
ND437_15525	COG0552	protein localization to endoplasmic reticulum
ND437_15530	COG0742	ribosomal rna small subunit methyltransferase
ND437_15535	COG3776	membrane
ND437_15550	COG3714	YhhN family
ND437_15565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND437_15575	COG0247	lactate metabolic process
ND437_15585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND437_15595	COG2271	Major facilitator Superfamily
ND437_15600	COG0584	glycerophosphoryl diester phosphodiesterase
ND437_15605	COG0561	phosphatase activity
ND437_15610	COG2267	carboxylic ester hydrolase activity
ND437_15615	COG1280	lysine exporter protein (LysE YggA)
ND437_15620	COG0514	ATP-dependent DNA helicase (RecQ)
ND437_15625	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND437_15630	COG2050	protein possibly involved in aromatic compounds catabolism
ND437_15650	COG5564	TIM-barrel signal transduction protein
ND437_15655	COG5441	Belongs to the UPF0261 family
ND437_15665	COG0210	DNA helicase
ND437_15670	COG1011	Hydrolase
ND437_15675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND437_15680	COG3159	Protein conserved in bacteria
ND437_15685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND437_15690	COG5567	small periplasmic lipoprotein
ND437_15700	COG3072	Adenylate cyclase
ND437_15705	COG0181	hydroxymethylbilane synthase activity
ND437_15710	COG1587	Uroporphyrinogen-III synthase
ND437_15715	COG2959	enzyme of heme biosynthesis
ND437_15720	COG3071	HemY protein
ND437_15765	COG2244	polysaccharide biosynthetic process
ND437_15770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND437_15775	COG0456	acetyltransferase
ND437_15780	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND437_15785	COG1088	dTDP-glucose 4,6-dehydratase activity
ND437_15790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND437_15795	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND437_15800	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND437_15805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND437_15810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND437_15815	COG3118	belongs to the thioredoxin family
ND437_15825	COG0248	Ppx GppA phosphatase
ND437_15835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND437_15850	COG3397	chitin binding
ND437_15860	COG0129	dihydroxy-acid dehydratase activity
ND437_15870	COG3978	acetolactate synthase activity
ND437_15890	COG3085	chromosome segregation
ND437_15895	COG0583	DNA-binding transcription factor activity
ND437_15965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND437_15975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND437_15975	COG0678	peroxiredoxin activity
ND437_15980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND437_16015	COG1629	transport
ND437_16020	COG0165	Argininosuccinate lyase
ND437_16025	COG0137	argininosuccinate synthase activity
ND437_16030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND437_16075	COG0460	homoserine dehydrogenase
ND437_16075	COG0527	aspartate kinase activity
ND437_16080	COG0626	cystathionine gamma-synthase activity
ND437_16085	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND437_16095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND437_16100	COG1609	Transcriptional regulator
ND437_16105	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND437_16110	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND437_16115	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND437_16120	COG1575	Belongs to the MenA family. Type 1 subfamily
ND437_16125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND437_16130	COG3074	FtsZ-dependent cytokinesis
ND437_16135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND437_16140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND437_16145	COG1494	fructose-1,6-bisphosphatase
ND437_16150	COG2814	Major facilitator Superfamily
ND437_16160	COG3152	Membrane
ND437_16175	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND437_16185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND437_16190	COG3678	ATP-independent chaperone mediated protein folding
ND437_16195	COG0745	RESPONSE REGULATOR receiver
ND437_16200	COG2205	protein histidine kinase activity
ND437_16205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND437_16210	COG1045	serine acetyltransferase
ND437_16215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND437_16220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND437_16225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND437_16230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND437_16235	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND437_16240	COG4942	peptidase
ND437_16245	COG2861	carbohydrate metabolic process
ND437_16260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND437_16265	COG0859	PFAM glycosyl transferase family 9
ND437_16270	COG0859	PFAM glycosyl transferase family 9
ND437_16275	COG1519	Transferase
ND437_16295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND437_16300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND437_16305	COG2003	Belongs to the UPF0758 family
ND437_16310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND437_16315	COG0756	dUTP diphosphatase activity
ND437_16320	COG1309	transcriptional regulator
ND437_16325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND437_16330	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND437_16335	COG1561	YicC-like family, N-terminal region
ND437_16365	COG1024	Enoyl-CoA hydratase
ND437_16370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND437_16385	COG2860	membrane
ND437_16390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND437_16400	COG1758	RNA polymerase activity
ND437_16405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND437_16410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND437_16415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND437_16420	COG0786	glutamate:sodium symporter activity
ND437_16425	COG2233	PERMEase
ND437_16430	COG2982	Protein involved in outer membrane biogenesis
ND437_16435	COG0456	acetyltransferase
ND437_16450	COG1011	Hydrolase
ND437_16465	COG3852	Histidine kinase
ND437_16475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND437_16485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND437_16490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND437_16490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND437_16495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND437_16500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND437_16505	COG3084	Protein conserved in bacteria
ND437_16515	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND437_16540	COG2186	Transcriptional regulator
ND437_16545	COG1609	Transcriptional regulator
ND437_16550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND437_16560	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND437_16565	COG1129	ABC transporter
ND437_16570	COG1869	D-ribose catabolic process
ND437_16575	COG3158	transport of potassium into the cell
ND437_16580	COG0714	Associated with various cellular activities
ND437_16585	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND437_16595	COG2502	aspartate--ammonia ligase
ND437_16600	COG1522	sequence-specific DNA binding
ND437_16605	COG0716	FMN binding
ND437_16610	COG0445	tRNA wobble uridine modification
ND437_16615	COG0357	Ribosomal RNA small subunit methyltransferase G
ND437_16620	COG3312	ion transport
ND437_16625	COG0356	it plays a direct role in the translocation of protons across the membrane
ND437_16635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND437_16645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND437_16650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND437_16660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND437_16675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND437_16680	COG0573	inorganic phosphate transmembrane transporter activity
ND437_16685	COG0581	inorganic phosphate transmembrane transporter activity
ND437_16695	COG0704	Plays a role in the regulation of phosphate uptake
ND437_16700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND437_16705	COG0765	amino acid transport
ND437_16710	COG0765	amino acid transport
ND437_16715	COG2252	PERMEase
ND437_16720	COG0840	transmembrane signaling receptor activity
ND437_16730	COG3121	Chaperone
ND437_16745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND437_16750	COG0706	membrane insertase activity
ND437_16760	COG0594	ribonuclease P activity
ND437_16765	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ND437_17080	COG3344	reverse transcriptase
ND437_17090	COG3850	Histidine kinase
ND437_17090	COG2205	protein histidine kinase activity
ND437_17090	COG3437	response regulator, receiver
ND437_17090	COG4999	Histidine kinase