locus-tag	class	description
ND440_00010	COG0592	DNA-directed DNA polymerase activity
ND440_00020	COG0187	DNA topoisomerase II activity
ND440_00025	COG0561	phosphatase activity
ND440_00030	COG0823	Involved in the tonB-independent uptake of proteins
ND440_00035	COG5645	(Lipo)protein
ND440_00050	COG0569	domain protein
ND440_00050	COG2985	domain, Protein
ND440_00055	COG3977	Valine--pyruvate aminotransferase
ND440_00060	COG2885	chlorophyll binding
ND440_00080	COG2818	Glycosylase
ND440_00130	COG2213	PTS system mannitol-specific
ND440_00130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND440_00140	COG3722	fumarate hydratase activity
ND440_00150	COG2258	MOSC domain
ND440_00155	COG0840	transmembrane signaling receptor activity
ND440_00160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND440_00175	COG0437	4 iron, 4 sulfur cluster binding
ND440_00180	COG2864	formate dehydrogenase
ND440_00190	COG1921	L-seryl-tRNASec selenium transferase activity
ND440_00195	COG3276	selenocysteine insertion sequence binding
ND440_00200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND440_00210	COG3274	enterobacterial common antigen metabolic process
ND440_00220	COG0582	viral genome integration into host DNA
ND440_00255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND440_00260	COG2986	histidine ammonia-lyase
ND440_00280	COG2194	sulfuric ester hydrolase activity
ND440_00285	COG2197	response regulator
ND440_00290	COG3851	Histidine kinase
ND440_00295	COG2271	Major facilitator Superfamily
ND440_00305	COG0747	negative chemotaxis
ND440_00310	COG0601	transmembrane transport
ND440_00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND440_00320	COG0444	Belongs to the ABC transporter superfamily
ND440_00325	COG4608	Belongs to the ABC transporter superfamily
ND440_00330	COG2194	sulfuric ester hydrolase activity
ND440_00355	COG1215	transferase activity, transferring glycosyl groups
ND440_00360	COG1215	transferase activity, transferring glycosyl groups
ND440_00365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND440_00370	COG3118	belongs to the thioredoxin family
ND440_00370	COG0457	Tetratricopeptide repeat
ND440_00375	COG2200	EAL domain
ND440_00375	COG2199	diguanylate cyclase activity
ND440_00380	COG1301	dicarboxylic acid transport
ND440_00385	COG0612	Peptidase, M16
ND440_00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND440_00395	COG1942	4-Oxalocrotonate Tautomerase
ND440_00400	COG2200	EAL domain
ND440_00405	COG2134	cdp-diacylglycerol pyrophosphatase
ND440_00410	COG1295	ribonuclease BN
ND440_00420	COG1301	dicarboxylic acid transport
ND440_00425	COG0626	cystathionine gamma-synthase activity
ND440_00465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND440_00470	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND440_00475	COG0339	signal peptide processing
ND440_00480	COG0742	ribosomal rna small subunit methyltransferase
ND440_00490	COG0589	response to stress
ND440_00500	COG0306	phosphate transporter
ND440_00505	COG2081	HI0933 family
ND440_00515	COG1247	-acetyltransferase
ND440_00520	COG1741	Belongs to the pirin family
ND440_00525	COG1609	Transcriptional regulator
ND440_00530	COG2610	gluconate transmembrane transporter activity
ND440_00535	COG3265	gluconokinase activity
ND440_00540	COG2095	MarC family integral membrane protein
ND440_00545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND440_00550	COG3275	phosphorelay sensor kinase activity
ND440_00555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND440_00560	COG1523	belongs to the glycosyl hydrolase 13 family
ND440_00565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND440_00570	COG0297	glycogen (starch) synthase activity
ND440_00575	COG0058	SHG alpha-glucan phosphorylase activity
ND440_00580	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND440_00585	COG1349	DNA-binding transcription factor activity
ND440_00590	COG0705	Rhomboid family
ND440_00600	COG2909	trisaccharide binding
ND440_00605	COG0058	SHG alpha-glucan phosphorylase activity
ND440_00610	COG1640	4-alpha-glucanotransferase
ND440_00620	COG1040	competence protein
ND440_00625	COG0596	Alpha beta hydrolase
ND440_00645	COG1918	ferrous iron import across plasma membrane
ND440_00650	COG2183	response to ionizing radiation
ND440_00675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND440_00690	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND440_00700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND440_00705	COG1011	Hydrolase
ND440_00715	COG0494	nUDIX hydrolase
ND440_00720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND440_00745	COG4796	Type ii and iii secretion system protein
ND440_00750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND440_00770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND440_00780	COG0180	Tryptophanyl-tRNA synthetase
ND440_00800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND440_00805	COG0402	S-adenosylhomocysteine deaminase activity
ND440_00810	COG0738	Major facilitator superfamily
ND440_00825	COG1609	Transcriptional regulator
ND440_00830	COG1486	melibiose metabolic process
ND440_00835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND440_00850	COG1289	transmembrane transporter activity
ND440_00855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND440_00885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND440_00890	COG3954	Phosphoribulokinase
ND440_00900	COG0429	hydrolase of the alpha beta-hydrolase fold
ND440_00910	COG0859	PFAM glycosyl transferase family 9
ND440_00915	COG1216	Glycosyl transferase, family 2
ND440_00920	COG0488	(ABC) transporter
ND440_00925	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND440_00935	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND440_00940	COG1047	Peptidyl-prolyl cis-trans
ND440_00950	COG0545	Peptidyl-prolyl cis-trans isomerase
ND440_00955	COG2964	Protein conserved in bacteria
ND440_00965	COG2923	Belongs to the DsrF TusC family
ND440_00970	COG2168	tRNA wobble position uridine thiolation
ND440_00975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND440_00980	COG0049	tRNA binding
ND440_00990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND440_01005	COG0051	transcription antitermination factor activity, RNA binding
ND440_01010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND440_01020	COG0089	rRNA binding
ND440_01025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND440_01030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND440_01035	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND440_01045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND440_01050	COG0255	Belongs to the universal ribosomal protein uL29 family
ND440_01055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND440_01060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND440_01070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND440_01095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND440_01100	COG1841	ribosomal large subunit assembly
ND440_01105	COG0200	Binds to the 23S rRNA
ND440_01110	COG0201	protein transport
ND440_01115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND440_01120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND440_01130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND440_01140	COG0203	ribosomal protein L17
ND440_01145	COG0789	Transcriptional regulator
ND440_01150	COG3036	rescue of stalled ribosome
ND440_01155	COG1970	mechanosensitive ion channel activity
ND440_01165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND440_01165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND440_01170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND440_01175	COG0242	peptide deformylase activity
ND440_01180	COG0758	DNA mediated transformation
ND440_01185	COG2922	Belongs to the Smg family
ND440_01190	COG0551	DNA topoisomerase type I activity
ND440_01195	COG0009	L-threonylcarbamoyladenylate synthase
ND440_01205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND440_01230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND440_01275	COG0250	Participates in transcription elongation, termination and antitermination
ND440_01280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND440_01290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND440_01295	COG0222	ribosome binding
ND440_01300	COG0085	RNA polymerase activity
ND440_01305	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND440_01315	COG2022	thiamine diphosphate biosynthetic process
ND440_01320	COG2104	thiamine diphosphate biosynthetic process
ND440_01325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND440_01340	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND440_01345	COG2816	NAD+ diphosphatase activity
ND440_01350	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND440_01355	COG1515	deoxyribonuclease V activity
ND440_01375	COG0151	Belongs to the GarS family
ND440_01380	COG0138	bifunctional purine biosynthesis protein purh
ND440_01420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND440_01455	COG0583	DNA-binding transcription factor activity
ND440_01535	COG1222	aaa ATPase
ND440_01560	COG0527	aspartate kinase activity
ND440_01570	COG3223	Belongs to the PsiE family
ND440_01575	COG3833	ABC-type maltose transport systems, permease component
ND440_01580	COG1175	transmembrane transport
ND440_01585	COG2182	Extracellular solute-binding protein
ND440_01600	COG4580	involved in the transport of maltose and maltodextrins
ND440_01620	COG2937	Belongs to the GPAT DAPAT family
ND440_01625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND440_01630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND440_01635	COG0735	belongs to the Fur family
ND440_01640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND440_01650	COG0604	alcohol dehydrogenase
ND440_01665	COG1448	Aminotransferase
ND440_01670	COG2315	Protein conserved in bacteria
ND440_01675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND440_01690	COG2252	PERMEase
ND440_01695	COG0025	NhaP-type Na H and K H
ND440_01700	COG0583	DNA-binding transcription factor activity
ND440_01705	COG1380	Effector of murein hydrolase LrgA
ND440_01710	COG1346	cytolysis
ND440_01720	COG1560	Kdo2-lipid A biosynthetic process
ND440_01730	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND440_01735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND440_01740	COG2264	protein methyltransferase activity
ND440_01745	COG4145	pantothenate transmembrane transporter activity
ND440_01750	COG3924	membrane
ND440_01755	COG0439	Biotin carboxylase
ND440_01760	COG0511	ligase activity, forming carbon-carbon bonds
ND440_01770	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND440_01775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND440_01780	COG0604	alcohol dehydrogenase
ND440_01785	COG2199	diguanylate cyclase activity
ND440_01785	COG2200	EAL domain
ND440_01790	COG1077	Cell shape determining protein MreB Mrl
ND440_01795	COG1792	Involved in formation and maintenance of cell shape
ND440_01800	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND440_01805	COG0424	maF-like protein
ND440_01815	COG3164	Protein of unknown function
ND440_01820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND440_01825	COG0312	modulator of DNA gyrase
ND440_01830	COG0583	DNA-binding transcription factor activity
ND440_01840	COG1566	PFAM secretion protein HlyD family protein
ND440_01845	COG1289	transmembrane transporter activity
ND440_01855	COG4290	ribonuclease
ND440_01860	COG2732	(Barnase) inhibitor
ND440_01865	COG3028	Belongs to the UPF0307 family
ND440_01870	COG0312	modulator of DNA gyrase
ND440_01875	COG3783	Cytochrome b(562)
ND440_01880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND440_01890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND440_01900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND440_01900	COG1263	PTS System
ND440_01905	COG0366	Alpha amylase catalytic
ND440_01915	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND440_01920	COG0540	Belongs to the ATCase OTCase family
ND440_01925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND440_01945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND440_01950	COG1137	ATPase activity
ND440_01955	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND440_01960	COG3117	lipopolysaccharide transmembrane transporter activity
ND440_01965	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND440_01970	COG0517	IMP dehydrogenase activity
ND440_01970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND440_01975	COG0530	calcium, potassium:sodium antiporter activity
ND440_01980	COG1127	ABC transporter
ND440_01985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND440_01990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND440_01995	COG2854	intermembrane phospholipid transfer
ND440_02000	COG3113	response to antibiotic
ND440_02005	COG5007	Belongs to the BolA IbaG family
ND440_02010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND440_02020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND440_02025	COG3105	Protein conserved in bacteria
ND440_02030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND440_02035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND440_02040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND440_02045	COG0625	glutathione transferase activity
ND440_02050	COG2969	positive regulation of protein catabolic process
ND440_02060	COG0493	'glutamate synthase
ND440_02065	COG0067	glutamate synthase
ND440_02065	COG0069	glutamate synthase activity
ND440_02065	COG0070	glutamate synthase
ND440_02070	COG1242	4 iron, 4 sulfur cluster binding
ND440_02085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND440_02095	COG2823	Periplasmic or secreted lipoprotein
ND440_02100	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND440_02130	COG1741	Belongs to the pirin family
ND440_02135	COG0583	DNA-binding transcription factor activity
ND440_02140	COG2259	Doxx family
ND440_02150	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND440_02155	COG4575	ribosome binding
ND440_02170	COG0586	Pfam SNARE associated Golgi protein
ND440_02185	COG2271	Major facilitator Superfamily
ND440_02200	COG2721	sulfolactate sulfo-lyase activity
ND440_02210	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND440_02215	COG0861	Integral membrane protein TerC family
ND440_02220	COG0673	inositol 2-dehydrogenase activity
ND440_02225	COG1451	nucleotide metabolic process
ND440_02240	COG1902	pentaerythritol trinitrate reductase activity
ND440_02240	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND440_02245	COG2831	hemolysin activation secretion protein
ND440_02250	COG3210	domain, Protein
ND440_02275	COG0463	Glycosyl transferase, family 2
ND440_02305	COG1028	Short-chain dehydrogenase reductase Sdr
ND440_02415	COG0358	DNA primase activity
ND440_02420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND440_02425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND440_02430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND440_02435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND440_02440	COG1968	undecaprenyl-diphosphatase activity
ND440_02445	COG0617	tRNA 3'-terminal CCA addition
ND440_02450	COG4991	sh3 domain protein
ND440_02455	COG3025	triphosphatase activity
ND440_02465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND440_02465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND440_02475	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND440_02480	COG3384	dioxygenase
ND440_02485	COG0754	glutathionylspermidine amidase activity
ND440_02490	COG5463	Belongs to the UPF0441 family
ND440_02495	COG1538	Outer membrane efflux protein
ND440_02500	COG0494	nUDIX hydrolase
ND440_02505	COG3151	Protein conserved in bacteria
ND440_02510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND440_02515	COG3150	esterase
ND440_02520	COG0187	DNA topoisomerase II activity
ND440_02525	COG0583	DNA-binding transcription factor activity
ND440_02530	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND440_02535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ND440_02545	COG2132	Multicopper oxidase
ND440_02555	COG0656	L-ascorbic acid biosynthetic process
ND440_02560	COG1979	alcohol dehydrogenase
ND440_02565	COG2207	Transcriptional regulator
ND440_02570	COG0586	Pfam SNARE associated Golgi protein
ND440_02575	COG0626	cystathionine gamma-synthase activity
ND440_02580	COG0811	peptide transport
ND440_02585	COG0848	biopolymer transport protein
ND440_02635	COG4964	Belongs to the GSP D family
ND440_02660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND440_02665	COG4774	siderophore transport
ND440_02675	COG3251	PFAM MbtH domain protein
ND440_02680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND440_02690	COG1120	ATPase activity
ND440_02695	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND440_02700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND440_02710	COG4592	Periplasmic binding protein
ND440_02715	COG1169	isochorismate synthase
ND440_02720	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND440_02725	COG3433	isochorismatase activity
ND440_02725	COG1535	isochorismatase
ND440_02730	COG1028	Short-chain dehydrogenase reductase Sdr
ND440_02745	COG0814	amino acid
ND440_02750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND440_02755	COG1882	Formate acetyltransferase
ND440_02760	COG1105	Belongs to the carbohydrate kinase PfkB family
ND440_02795	COG0741	lytic transglycosylase activity
ND440_02800	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND440_02805	COG1194	a g-specific adenine glycosylase
ND440_02815	COG3171	Protein conserved in bacteria
ND440_02830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND440_02835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND440_02840	COG1872	DUF167
ND440_02845	COG0762	integral membrane protein
ND440_02850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND440_02855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND440_02860	COG2805	Type II/IV secretion system protein
ND440_02870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND440_02875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND440_02880	COG1678	Uncharacterized ACR, COG1678
ND440_02885	COG0189	ligase activity
ND440_02890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND440_02895	COG2356	endonuclease I
ND440_02900	COG3091	SprT-like family
ND440_02905	COG0640	Transcriptional regulator
ND440_02920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND440_02925	COG1166	arginine decarboxylase activity
ND440_02935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND440_02940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND440_02945	COG0126	phosphoglycerate kinase activity
ND440_02950	COG0191	fructose-bisphosphate aldolase activity
ND440_02960	COG1279	arginine transmembrane transporter activity
ND440_02975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND440_02980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND440_02985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND440_02995	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND440_03005	COG0006	proline dipeptidase activity
ND440_03010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND440_03015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND440_03020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND440_03040	COG1272	protein, Hemolysin III
ND440_03050	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND440_03060	COG0716	FMN binding
ND440_03065	COG4974	Belongs to the 'phage' integrase family
ND440_03070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND440_03075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND440_03085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND440_03095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND440_03100	COG1127	ABC transporter
ND440_03130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND440_03140	COG2165	general secretion pathway protein
ND440_03195	COG0583	DNA-binding transcription factor activity
ND440_03200	COG0583	DNA-binding transcription factor activity
ND440_03210	COG1609	Transcriptional regulator
ND440_03215	COG0318	PFAM AMP-dependent synthetase and ligase
ND440_03215	COG0204	Acyl-transferase
ND440_03220	COG0477	Major facilitator Superfamily
ND440_03225	COG0667	Aldo Keto reductase
ND440_03230	COG0861	Integral membrane protein TerC family
ND440_03235	COG3066	DNA modification
ND440_03245	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND440_03250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND440_03275	COG4967	type IV pilus modification protein PilV
ND440_03280	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND440_03285	COG1025	Belongs to the peptidase M16 family
ND440_03290	COG1074	ATP-dependent DNA helicase activity
ND440_03295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND440_03300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND440_03300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND440_03305	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND440_03325	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND440_03330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND440_03335	COG2166	iron-sulfur cluster assembly
ND440_03340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND440_03350	COG0583	DNA-binding transcription factor activity
ND440_03355	COG2363	Small membrane protein
ND440_03360	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND440_03375	COG1611	Belongs to the LOG family
ND440_03390	COG3098	single-species biofilm formation
ND440_03395	COG0564	pseudouridine synthase activity
ND440_03410	COG2171	N-acyltransferase activity
ND440_03415	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND440_03435	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND440_03440	COG0528	UMP kinase activity
ND440_03460	COG0575	Belongs to the CDS family
ND440_03465	COG0750	zinc metalloprotease
ND440_03475	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND440_03480	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND440_03500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND440_03505	COG0587	DNA-directed DNA polymerase activity
ND440_03510	COG0825	malonyl-CoA metabolic process
ND440_03525	COG0346	lactoylglutathione lyase activity
ND440_03540	COG4568	rho-dependent transcription termination
ND440_03550	COG4681	YaeQ
ND440_03560	COG3015	lipoprotein NlpE involved in copper resistance
ND440_03565	COG0442	prolyl-tRNA aminoacylation
ND440_03570	COG1720	tRNA m6t6A37 methyltransferase activity
ND440_03580	COG1464	Belongs to the NlpA lipoprotein family
ND440_03585	COG2011	ABC-type metal ion transport system permease component
ND440_03595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND440_03625	COG3021	interspecies interaction between organisms
ND440_03630	COG0741	lytic transglycosylase activity
ND440_03630	COG1388	LysM domain
ND440_03640	COG2226	methyltransferase
ND440_03650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND440_03660	COG1960	acyl-CoA dehydrogenase activity
ND440_03665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND440_03670	COG0121	glutamine amidotransferase
ND440_03675	COG3034	peptidoglycan biosynthetic process
ND440_03685	COG1805	sodium ion transport
ND440_03690	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND440_03695	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND440_03700	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND440_03710	COG1477	protein flavinylation
ND440_03715	COG2991	Protein conserved in bacteria
ND440_03725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND440_03730	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND440_03735	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND440_03740	COG1073	alpha beta
ND440_03755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND440_03790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND440_03810	COG4126	flavin adenine dinucleotide binding
ND440_03820	COG2974	May be involved in recombination
ND440_03825	COG1940	carbohydrate kinase activity
ND440_03830	COG0419	ATPase involved in DNA repair
ND440_03835	COG0420	3'-5' exonuclease activity
ND440_03840	COG0745	RESPONSE REGULATOR receiver
ND440_03845	COG5002	protein histidine kinase activity
ND440_03860	COG1113	amino acid transport
ND440_03865	COG0366	Alpha amylase catalytic
ND440_03870	COG0300	oxidoreductase activity
ND440_03875	COG0450	alkyl hydroperoxide reductase
ND440_03880	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND440_03895	COG1862	Preprotein translocase
ND440_03900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND440_03905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND440_03910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND440_03915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND440_03915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND440_03920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND440_03930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND440_03935	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND440_03940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND440_03945	COG0142	geranyltranstransferase activity
ND440_03980	COG0693	protein deglycase activity
ND440_03985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND440_03990	COG1666	GTP binding
ND440_03995	COG2814	Major facilitator Superfamily
ND440_04005	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND440_04010	COG1845	cytochrome c oxidase, subunit III
ND440_04015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND440_04020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND440_04030	COG2223	nitrite transmembrane transporter activity
ND440_04035	COG3056	Lipoprotein
ND440_04040	COG0271	Belongs to the BolA IbaG family
ND440_04050	COG0740	serine-type endopeptidase activity
ND440_04055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND440_04060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND440_04065	COG0776	regulation of translation
ND440_04070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND440_04075	COG1555	photosystem II stabilization
ND440_04080	COG0824	Thioesterase
ND440_04085	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND440_04090	COG4533	DNA binding
ND440_04105	COG1522	sequence-specific DNA binding
ND440_04110	COG1132	(ABC) transporter
ND440_04115	COG1132	(ABC) transporter
ND440_04120	COG0347	Belongs to the P(II) protein family
ND440_04125	COG0004	ammonium transporteR
ND440_04130	COG1946	Acyl-CoA thioesterase
ND440_04135	COG3695	enzyme binding
ND440_04160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND440_04165	COG0254	rRNA binding
ND440_04170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND440_04175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND440_04180	COG1309	transcriptional regulator
ND440_04185	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND440_04190	COG1196	nuclear chromosome segregation
ND440_04190	COG3264	Mechanosensitive ion channel
ND440_04205	COG2832	Protein of unknown function (DUF454)
ND440_04210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND440_04250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND440_04255	COG0326	Molecular chaperone. Has ATPase activity
ND440_04270	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND440_04275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND440_04280	COG4651	solute:proton antiporter activity
ND440_04280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND440_04285	COG0737	Belongs to the 5'-nucleotidase family
ND440_04290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND440_04295	COG3735	TraB family
ND440_04300	COG2217	Heavy metal translocating P-type atpase
ND440_04305	COG0789	Transcriptional regulator
ND440_04310	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND440_04315	COG0330	HflC and HflK could
ND440_04320	COG3118	belongs to the thioredoxin family
ND440_04325	COG0300	oxidoreductase activity
ND440_04330	COG2755	lipolytic protein G-D-S-L family
ND440_04335	COG4181	ATPase activity
ND440_04340	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND440_04345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND440_04350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND440_04355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND440_04360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND440_04385	COG3188	usher protein
ND440_04390	COG3121	Chaperone
ND440_04420	COG2501	S4 domain
ND440_04425	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND440_04440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND440_04445	COG1393	Belongs to the ArsC family
ND440_04455	COG1022	Amp-dependent synthetase and ligase
ND440_04480	COG3038	cytochrome b561
ND440_04510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND440_04520	COG1215	transferase activity, transferring glycosyl groups
ND440_04540	COG3250	beta-galactosidase activity
ND440_04555	COG1309	transcriptional regulator
ND440_04585	COG2197	response regulator
ND440_04590	COG1278	Cold shock
ND440_04610	COG3706	GGDEF domain
ND440_04620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND440_04630	COG2921	Belongs to the UPF0250 family
ND440_04635	COG1686	Belongs to the peptidase S11 family
ND440_04640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND440_04645	COG0772	Belongs to the SEDS family
ND440_04650	COG0768	penicillin binding
ND440_04655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND440_04660	COG0799	negative regulation of ribosome biogenesis
ND440_04665	COG0582	viral genome integration into host DNA
ND440_04725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND440_04790	COG0305	Participates in initiation and elongation during chromosome replication
ND440_04815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ND440_04890	COG0616	signal peptide processing
ND440_04930	COG4386	tail sheath protein
ND440_04970	COG3299	homolog of phage Mu protein gp47
ND440_04985	COG5301	cellulose 1,4-beta-cellobiosidase activity
ND440_04995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND440_05000	COG1466	dna polymerase III delta subunit
ND440_05005	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND440_05015	COG2888	peptidyl-tyrosine sulfation
ND440_05020	COG1126	abc transporter atp-binding protein
ND440_05025	COG0765	amino acid transport
ND440_05030	COG0765	amino acid transport
ND440_05040	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND440_05045	COG4535	Mg2 and Co2 transporter CorC
ND440_05050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND440_05055	COG1702	phosphate starvation-inducible protein PhoH
ND440_05060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND440_05065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND440_05100	COG0367	asparagine synthase
ND440_05105	COG0647	UMP catabolic process
ND440_05110	COG1846	Transcriptional regulator
ND440_05110	COG1940	carbohydrate kinase activity
ND440_05115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND440_05125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND440_05125	COG1263	PTS System
ND440_05125	COG2190	(PTS) system
ND440_05150	COG0735	belongs to the Fur family
ND440_05160	COG0840	transmembrane signaling receptor activity
ND440_05170	COG0596	Alpha beta hydrolase
ND440_05175	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND440_05180	COG0033	Phosphoglucomutase
ND440_05190	COG0745	RESPONSE REGULATOR receiver
ND440_05195	COG2205	protein histidine kinase activity
ND440_05200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND440_05205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND440_05225	COG3272	Protein of unknown function (DUF1722)
ND440_05230	COG0415	Belongs to the DNA photolyase family
ND440_05235	COG5212	phosphodiesterase
ND440_05240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND440_05245	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND440_05250	COG1984	allophanate hydrolase subunit 2
ND440_05255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND440_05290	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND440_05295	COG1053	succinate dehydrogenase
ND440_05300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND440_05305	COG0567	Dehydrogenase, E1 component
ND440_05310	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND440_05315	COG0045	succinate-CoA ligase (ADP-forming) activity
ND440_05320	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND440_05325	COG0737	Belongs to the 5'-nucleotidase family
ND440_05330	COG1271	oxidase subunit
ND440_05335	COG1294	oxidase, subunit
ND440_05340	COG4890	Cyd operon protein YbgT
ND440_05345	COG3790	cyd operon protein YbgE
ND440_05350	COG0824	Thioesterase
ND440_05355	COG0811	peptide transport
ND440_05360	COG0848	biopolymer transport protein
ND440_05365	COG3064	Membrane
ND440_05365	COG3064	Membrane
ND440_05370	COG0823	Involved in the tonB-independent uptake of proteins
ND440_05375	COG2885	chlorophyll binding
ND440_05380	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND440_05410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND440_05420	COG2205	protein histidine kinase activity
ND440_05420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND440_05430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND440_05435	COG0588	phosphoglycerate mutase activity
ND440_05445	COG2017	converts alpha-aldose to the beta-anomer
ND440_05455	COG1085	galactose-1-phosphate uridylyltransferase
ND440_05460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND440_05475	COG3585	molybdate ion transport
ND440_05475	COG2005	Transcriptional regulator
ND440_05485	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND440_05490	COG4149	molybdate abc transporter
ND440_05500	COG0561	phosphatase activity
ND440_05505	COG2706	6-phosphogluconolactonase activity
ND440_05520	COG0156	8-amino-7-oxononanoate synthase activity
ND440_05525	COG2226	methyltransferase
ND440_05540	COG0556	nucleotide-excision repair
ND440_05545	COG4628	conserved protein (DUF2132)
ND440_05560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND440_05565	COG1120	ATPase activity
ND440_05570	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND440_05575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND440_05585	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND440_05590	COG0314	molybdopterin synthase activity
ND440_05595	COG0670	Belongs to the BI1 family
ND440_05600	COG0842	Transport permease protein
ND440_05605	COG0842	Transport permease protein
ND440_05610	COG1131	(ABC) transporter
ND440_05615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND440_05620	COG1309	transcriptional regulator
ND440_05625	COG0513	Belongs to the DEAD box helicase family
ND440_05630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND440_05640	COG1686	Belongs to the peptidase S11 family
ND440_05645	COG0277	FAD linked oxidase domain protein
ND440_05665	COG2261	transglycosylase associated protein
ND440_05675	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND440_05685	COG3639	organic phosphonate transmembrane transporter activity
ND440_05690	COG4807	Protein conserved in bacteria
ND440_05695	COG2897	thiosulfate sulfurtransferase activity
ND440_05700	COG1732	Glycine betaine
ND440_05705	COG1174	glycine betaine transport
ND440_05710	COG1125	glycine betaine transport
ND440_05715	COG1174	glycine betaine transport
ND440_05720	COG0531	amino acid
ND440_05725	COG1982	Orn Lys Arg decarboxylase major
ND440_05735	COG0697	spore germination
ND440_05750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND440_05755	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND440_05760	COG1126	abc transporter atp-binding protein
ND440_05765	COG0765	amino acid transport
ND440_05770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND440_05790	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND440_05795	COG2239	Acts as a magnesium transporter
ND440_05800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND440_05805	COG0488	(ABC) transporter
ND440_05810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND440_05815	COG0303	'Molybdopterin
ND440_05835	COG0583	DNA-binding transcription factor activity
ND440_05840	COG0477	Major facilitator Superfamily
ND440_05845	COG0302	gtp cyclohydrolase
ND440_05850	COG2311	Membrane
ND440_05875	COG2949	membrane
ND440_05880	COG0281	malic enzyme
ND440_05890	COG0583	DNA-binding transcription factor activity
ND440_05900	COG1346	cytolysis
ND440_05905	COG1380	Effector of murein hydrolase LrgA
ND440_05915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND440_05915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND440_05920	COG0489	protein tyrosine kinase activity
ND440_05925	COG0572	uridine kinase
ND440_05930	COG0717	Belongs to the dCTP deaminase family
ND440_05935	COG2982	Protein involved in outer membrane biogenesis
ND440_05940	COG3069	C4-dicarboxylate transmembrane transporter activity
ND440_05945	COG1253	flavin adenine dinucleotide binding
ND440_05950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND440_05955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND440_05960	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND440_05970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND440_05970	COG0140	phosphoribosyl-ATP diphosphatase activity
ND440_05980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND440_05995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND440_06000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND440_06015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND440_06020	COG0625	glutathione transferase activity
ND440_06035	COG0626	cystathionine gamma-synthase activity
ND440_06045	COG1686	Belongs to the peptidase S11 family
ND440_06050	COG1760	l-serine dehydratase
ND440_06055	COG0814	amino acid
ND440_06060	COG1349	DNA-binding transcription factor activity
ND440_06070	COG0671	phosphoesterase, PA-phosphatase related
ND440_06080	COG2985	domain, Protein
ND440_06080	COG0569	domain protein
ND440_06100	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND440_06105	COG3842	ATPase activity
ND440_06110	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND440_06115	COG1177	transmembrane transport
ND440_06130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND440_06135	COG4160	amino acid transport
ND440_06140	COG4215	(ABC) transporter
ND440_06145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND440_06150	COG1126	abc transporter atp-binding protein
ND440_06160	COG0393	Putative heavy-metal-binding
ND440_06165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND440_06170	COG0702	epimerase
ND440_06175	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND440_06180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND440_06185	COG1151	hydroxylamine reductase activity
ND440_06190	COG2431	L-lysine efflux transmembrane transporter activity
ND440_06195	COG3593	DNA synthesis involved in DNA repair
ND440_06200	COG2990	Protein conserved in bacteria
ND440_06205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND440_06215	COG1278	Cold shock
ND440_06220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND440_06225	COG0542	response to heat
ND440_06230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND440_06240	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND440_06250	COG0492	ferredoxin-NADP+ reductase activity
ND440_06255	COG1522	sequence-specific DNA binding
ND440_06260	COG3107	peptidoglycan biosynthetic process
ND440_06260	COG1674	ftsk spoiiie
ND440_06265	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND440_06270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND440_06275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND440_06280	COG2814	Major facilitator Superfamily
ND440_06285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND440_06290	COG1882	Formate acetyltransferase
ND440_06295	COG2116	formate transmembrane transporter activity
ND440_06300	COG1944	ATP diphosphatase activity
ND440_06305	COG0252	asparaginase activity
ND440_06315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND440_06325	COG0539	negative regulation of cytoplasmic translation
ND440_06335	COG0658	competence protein
ND440_06335	COG2333	competence protein COMEC
ND440_06345	COG1663	tetraacyldisaccharide 4'-kinase activity
ND440_06350	COG5383	Protein conserved in bacteria
ND440_06360	COG1278	Cold shock
ND440_06365	COG2835	tetraacyldisaccharide 4'-kinase activity
ND440_06370	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND440_06375	COG3173	Aminoglycoside phosphotransferase
ND440_06380	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND440_06385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND440_06390	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND440_06400	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND440_06405	COG2989	Protein conserved in bacteria
ND440_06410	COG3108	Peptidase M15
ND440_06415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND440_06420	COG1448	Aminotransferase
ND440_06435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND440_06440	COG0308	aminopeptidase N
ND440_06445	COG0167	dihydroorotate dehydrogenase activity
ND440_06455	COG3217	Mosc domain protein beta barrel domain protein
ND440_06455	COG0633	Ferredoxin
ND440_06460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND440_06460	COG0116	Belongs to the methyltransferase superfamily
ND440_06465	COG0488	(ABC) transporter
ND440_06470	COG2995	paraquat-inducible protein a
ND440_06475	COG3008	intermembrane lipid transfer
ND440_06475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND440_06480	COG3009	Protein conserved in bacteria
ND440_06485	COG3130	regulation of translation
ND440_06490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND440_06495	COG1067	ATP-dependent peptidase activity
ND440_06500	COG3120	sequence-specific DNA binding
ND440_06510	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND440_06515	COG3070	regulator of competence-specific genes
ND440_06520	COG1289	transmembrane transporter activity
ND440_06525	COG3304	Inner membrane component domain
ND440_06530	COG0210	DNA helicase
ND440_06535	COG1803	Methylglyoxal synthase
ND440_06545	COG1832	CoA-binding protein
ND440_06550	COG3785	DNA binding
ND440_06555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND440_06560	COG1254	Belongs to the acylphosphatase family
ND440_06565	COG2920	part of a sulfur-relay system
ND440_06575	COG0288	reversible hydration of carbon dioxide
ND440_06595	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND440_06600	COG2943	transferase activity, transferring hexosyl groups
ND440_06620	COG1560	Kdo2-lipid A biosynthetic process
ND440_06630	COG0628	permease
ND440_06655	COG0418	dihydroorotase activity
ND440_06660	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND440_06670	COG1530	ribonuclease E activity
ND440_06675	COG0564	pseudouridine synthase activity
ND440_06680	COG0424	maF-like protein
ND440_06685	COG1399	metal-binding, possibly nucleic acid-binding protein
ND440_06690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND440_06700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND440_06705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND440_06715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND440_06720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND440_06725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND440_06730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND440_06735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND440_06740	COG0470	DNA polymerase III
ND440_06745	COG0084	hydrolase, TatD family'
ND440_06750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND440_06750	COG1263	PTS System
ND440_06755	COG0537	adenosine 5'-monophosphoramidase activity
ND440_06760	COG5633	Lipoprotein
ND440_06765	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND440_06780	COG3150	esterase
ND440_06785	COG1252	NADH dehydrogenase
ND440_06790	COG3134	Outer membrane lipoprotein
ND440_06795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND440_06800	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND440_06810	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND440_06830	COG2850	peptidyl-arginine hydroxylation
ND440_06835	COG2205	protein histidine kinase activity
ND440_06840	COG0745	RESPONSE REGULATOR receiver
ND440_06850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND440_06860	COG0482	sulfurtransferase activity
ND440_06870	COG1187	pseudouridine synthase activity
ND440_06875	COG0538	isocitrate dehydrogenase activity
ND440_06880	COG2771	luxR family
ND440_06885	COG3916	Acyl-homoserine-lactone synthase
ND440_06890	COG2723	6-phospho-beta-galactosidase activity
ND440_06900	COG0339	signal peptide processing
ND440_06910	COG3493	citrate carrier protein
ND440_06915	COG4565	transcriptional regulatory protein
ND440_06920	COG3290	protein histidine kinase activity
ND440_06925	COG0471	metal ion transport
ND440_06965	COG4977	sequence-specific DNA binding
ND440_06970	COG1702	phosphate starvation-inducible protein PhoH
ND440_06975	COG0387	Pfam Sodium calcium exchanger
ND440_06980	COG2375	cellular response to nickel ion
ND440_06985	COG3850	Histidine kinase
ND440_06995	COG1294	oxidase, subunit
ND440_07000	COG1271	oxidase subunit
ND440_07005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND440_07010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND440_07015	COG3138	arginine N-succinyltransferase
ND440_07025	COG3724	N-succinylarginine dihydrolase activity
ND440_07045	COG1228	amidohydrolase
ND440_07055	COG0402	S-adenosylhomocysteine deaminase activity
ND440_07075	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND440_07080	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND440_07085	COG3383	formate dehydrogenase (NAD+) activity
ND440_07090	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND440_07095	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND440_07105	COG3260	NADH ubiquinone oxidoreductase 20
ND440_07110	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND440_07115	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND440_07115	COG3261	NADH dehydrogenase
ND440_07120	COG0650	Formate hydrogenlyase subunit 4
ND440_07125	COG0651	ATP synthesis coupled electron transport
ND440_07130	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND440_07140	COG0375	protein maturation
ND440_07145	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND440_07150	COG0298	carbon dioxide binding
ND440_07155	COG0409	Hydrogenase expression formation protein
ND440_07160	COG0309	Hydrogenase expression formation protein (HypE)
ND440_07195	COG2207	Transcriptional regulator
ND440_07195	COG3708	Transcriptional regulator
ND440_07200	COG0012	GTP binding
ND440_07210	COG0193	aminoacyl-tRNA hydrolase activity
ND440_07220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND440_07230	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND440_07235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND440_07240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND440_07245	COG2890	protein-(glutamine-N5) methyltransferase activity
ND440_07260	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND440_07265	COG0659	secondary active sulfate transmembrane transporter activity
ND440_07270	COG3706	GGDEF domain
ND440_07295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND440_07305	COG3381	protein complex oligomerization
ND440_07325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND440_07335	COG0673	inositol 2-dehydrogenase activity
ND440_07340	COG0728	peptidoglycan biosynthetic process
ND440_07365	COG3102	Protein conserved in bacteria
ND440_07370	COG3142	Participates in the control of copper homeostasis
ND440_07385	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND440_07390	COG1801	Protein of unknown function DUF72
ND440_07400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND440_07405	COG0494	nUDIX hydrolase
ND440_07415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND440_07425	COG2255	four-way junction helicase activity
ND440_07430	COG3104	oligopeptide transport
ND440_07435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND440_07440	COG1121	(ABC) transporter
ND440_07445	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND440_07450	COG0739	heme binding
ND440_07455	COG1560	Kdo2-lipid A biosynthetic process
ND440_07460	COG0469	pyruvate kinase activity
ND440_07465	COG1737	Transcriptional regulator
ND440_07470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND440_07475	COG0800	Aldolase
ND440_07485	COG2076	Multidrug Resistance protein
ND440_07490	COG0251	oxidation-reduction process
ND440_07495	COG1199	ATP-dependent helicase activity
ND440_07500	COG1214	PFAM Peptidase M22, glycoprotease
ND440_07505	COG3065	identical protein binding
ND440_07510	COG0318	PFAM AMP-dependent synthetase and ligase
ND440_07515	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND440_07520	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND440_07525	COG2894	cell division
ND440_07530	COG0850	regulation of cytokinetic process
ND440_07535	COG3100	YcgL domain-containing protein
ND440_07540	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND440_07545	COG2983	Belongs to the UPF0260 family
ND440_07565	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND440_07575	COG2719	SpoVR family
ND440_07580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND440_07585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND440_07590	COG2814	Major facilitator Superfamily
ND440_07600	COG2202	Pas domain
ND440_07600	COG2200	EAL domain
ND440_07600	COG2199	diguanylate cyclase activity
ND440_07620	COG2718	Belongs to the UPF0229 family
ND440_07625	COG2766	serine protein kinase
ND440_07635	COG3713	MltA-interacting MipA family protein
ND440_07640	COG2194	sulfuric ester hydrolase activity
ND440_07655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND440_07660	COG3139	Protein of unknown function (DUF1315)
ND440_07665	COG1335	isochorismatase
ND440_07670	COG0252	asparaginase activity
ND440_07675	COG0616	signal peptide processing
ND440_07680	COG0778	Nitroreductase
ND440_07690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND440_07700	COG0494	nUDIX hydrolase
ND440_07705	COG0708	Exodeoxyribonuclease III
ND440_07740	COG0788	formyltetrahydrofolate deformylase activity
ND440_07750	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND440_07755	COG0745	RESPONSE REGULATOR receiver
ND440_07775	COG1454	alcohol dehydrogenase
ND440_07775	COG1012	belongs to the aldehyde dehydrogenase family
ND440_07785	COG2095	MarC family integral membrane protein
ND440_07790	COG4166	transmembrane transport
ND440_07805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND440_07820	COG3099	Belongs to the UPF0263 family
ND440_07825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND440_07845	COG2350	Protein conserved in bacteria
ND440_07860	COG3710	Transcriptional regulator
ND440_07895	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND440_07920	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND440_07925	COG3047	cAMP biosynthetic process
ND440_07940	COG0133	tryptophan synthase activity
ND440_07945	COG0135	phosphoribosylanthranilate isomerase activity
ND440_07945	COG0134	indole-3-glycerol-phosphate synthase activity
ND440_07955	COG0512	Glutamine amidotransferase of anthranilate synthase
ND440_07965	COG0613	PHP domain protein
ND440_07970	COG0009	L-threonylcarbamoyladenylate synthase
ND440_07975	COG1187	pseudouridine synthase activity
ND440_07985	COG1028	Short-chain dehydrogenase reductase Sdr
ND440_07990	COG0616	signal peptide processing
ND440_08005	COG0583	DNA-binding transcription factor activity
ND440_08030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND440_08040	COG0671	phosphoesterase, PA-phosphatase related
ND440_08045	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND440_08050	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND440_08070	COG0023	Translation Initiation Factor
ND440_08080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND440_08085	COG5002	protein histidine kinase activity
ND440_08085	COG5001	Diguanylate cyclase
ND440_08085	COG3447	MASE1 domain protein
ND440_08090	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND440_08095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND440_08105	COG4659	FMN binding
ND440_08115	COG2207	Transcriptional regulator
ND440_08115	COG3708	Transcriptional regulator
ND440_08130	COG4657	Part of a membrane complex involved in electron transport
ND440_08140	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND440_08150	COG0673	inositol 2-dehydrogenase activity
ND440_08155	COG0385	Bile acid
ND440_08160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND440_08165	COG5339	Protein conserved in bacteria
ND440_08170	COG1482	cell wall glycoprotein biosynthetic process
ND440_08175	COG0114	fumarate hydratase activity
ND440_08185	COG1940	carbohydrate kinase activity
ND440_08190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND440_08210	COG1742	UPF0060 membrane protein
ND440_08215	COG4221	oxidoreductase activity
ND440_08220	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND440_08240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND440_08280	COG1011	Hydrolase
ND440_08290	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND440_08295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND440_08300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND440_08305	COG0589	response to stress
ND440_08335	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND440_08340	COG3623	hexulose-6-phosphate isomerase
ND440_08345	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND440_08350	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND440_08360	COG0531	amino acid
ND440_08370	COG0745	RESPONSE REGULATOR receiver
ND440_08375	COG2205	protein histidine kinase activity
ND440_08390	COG2207	Transcriptional regulator
ND440_08395	COG1881	PFAM PEBP family protein
ND440_08405	COG3591	Belongs to the peptidase S1B family
ND440_08410	COG1643	Atp-dependent helicase
ND440_08415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND440_08420	COG3784	Protein of unknown function (DUF1318)
ND440_08435	COG2911	Protein conserved in bacteria
ND440_08440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND440_08445	COG3187	Heat shock protein
ND440_08450	COG3042	response to heat
ND440_08455	COG1285	pathogenesis
ND440_08465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND440_08465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND440_08465	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND440_08465	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND440_08480	COG4166	transmembrane transport
ND440_08485	COG2866	Carboxypeptidase
ND440_08490	COG4948	Mandelate Racemase Muconate Lactonizing
ND440_08495	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND440_08505	COG5642	Protein of unknown function (DUF2384)
ND440_08510	COG5654	RES domain protein
ND440_08515	COG3768	UPF0283 membrane protein
ND440_08520	COG3106	COG3106 Predicted ATPase
ND440_08530	COG1983	PspC domain protein
ND440_08540	COG1842	Phage shock protein A
ND440_08545	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND440_08560	COG4166	transmembrane transport
ND440_08570	COG4171	peptide transport system, permease
ND440_08575	COG4172	Belongs to the ABC transporter superfamily
ND440_08580	COG4172	Belongs to the ABC transporter superfamily
ND440_08590	COG3104	oligopeptide transport
ND440_08600	COG0484	heat shock protein binding
ND440_08645	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND440_08650	COG3133	Outer membrane lipoprotein
ND440_08655	COG1846	Transcriptional regulator
ND440_08665	COG4989	oxidoreductase activity
ND440_08670	COG3313	Fe-S protein
ND440_08675	COG2194	sulfuric ester hydrolase activity
ND440_08680	COG1309	transcriptional regulator
ND440_08685	COG1902	pentaerythritol trinitrate reductase activity
ND440_08700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND440_08705	COG0791	NLP P60 protein
ND440_08710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND440_08720	COG1609	Transcriptional regulator
ND440_08725	COG0583	DNA-binding transcription factor activity
ND440_08730	COG2814	Major facilitator Superfamily
ND440_08735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND440_08740	COG0307	riboflavin synthase, alpha
ND440_08775	COG1388	LysM domain
ND440_08775	COG1376	ErfK ybiS ycfS ynhG family protein
ND440_08780	COG2166	iron-sulfur cluster assembly
ND440_08790	COG0719	Fe-S assembly protein
ND440_08795	COG0396	ATPase activity
ND440_08800	COG0719	Fe-S assembly protein
ND440_08805	COG0316	Belongs to the HesB IscA family
ND440_08810	COG2050	protein possibly involved in aromatic compounds catabolism
ND440_08815	COG0247	lactate metabolic process
ND440_08815	COG0277	FAD linked oxidase domain protein
ND440_08820	COG0628	permease
ND440_08830	COG0574	Belongs to the PEP-utilizing enzyme family
ND440_08830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND440_08835	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND440_08840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND440_08850	COG4771	TonB-dependent receptor
ND440_08855	COG3720	iron ion transport
ND440_08860	COG4558	Periplasmic binding protein
ND440_08865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND440_08870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND440_08880	COG0095	Lipoate-protein ligase
ND440_08885	COG0791	NLP P60 protein
ND440_08890	COG2076	Multidrug Resistance protein
ND440_08895	COG2076	Multidrug Resistance protein
ND440_08900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND440_08915	COG0463	Glycosyl transferase, family 2
ND440_08920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND440_08930	COG4139	cobalamin transport
ND440_09000	COG0776	regulation of translation
ND440_09070	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND440_09075	COG1121	(ABC) transporter
ND440_09080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND440_09085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND440_09090	COG3001	Fructosamine kinase
ND440_09100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND440_09105	COG1988	membrane-bound metal-dependent
ND440_09110	COG1823	symporter activity
ND440_09115	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND440_09125	COG2814	Major facilitator Superfamily
ND440_09135	COG0501	Belongs to the peptidase M48B family
ND440_09140	COG0793	Belongs to the peptidase S41A family
ND440_09150	COG1956	GAF domain-containing protein
ND440_09155	COG2995	paraquat-inducible protein a
ND440_09160	COG3008	intermembrane lipid transfer
ND440_09165	COG2203	Gaf domain
ND440_09165	COG5001	Diguanylate cyclase
ND440_09165	COG4251	negative regulation of phosphorylation
ND440_09165	COG3706	GGDEF domain
ND440_09245	COG1276	copper resistance
ND440_09250	COG2372	response to copper ion
ND440_09255	COG1528	Iron-storage protein
ND440_09270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND440_09275	COG1770	oligopeptidase
ND440_09285	COG3097	Belongs to the UPF0267 family
ND440_09290	COG3141	response to X-ray
ND440_09295	COG0513	Belongs to the DEAD box helicase family
ND440_09315	COG0494	nUDIX hydrolase
ND440_09320	COG1760	l-serine dehydratase
ND440_09325	COG1253	flavin adenine dinucleotide binding
ND440_09330	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND440_09330	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND440_09335	COG3715	PTS system
ND440_09340	COG3716	PTS system mannose fructose sorbose family IID component
ND440_09345	COG4811	Protein of unknown function (DUF986)
ND440_09350	COG1971	Probably functions as a manganese efflux pump
ND440_09370	COG1960	acyl-CoA dehydrogenase activity
ND440_09380	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND440_09410	COG2226	methyltransferase
ND440_09415	COG0768	penicillin binding
ND440_09420	COG1496	oxidoreductase activity
ND440_09440	COG1113	amino acid transport
ND440_09475	COG2207	Transcriptional regulator
ND440_09495	COG1132	(ABC) transporter
ND440_09505	COG5001	Diguanylate cyclase
ND440_09505	COG3706	GGDEF domain
ND440_09505	COG2203	Gaf domain
ND440_09505	COG4251	negative regulation of phosphorylation
ND440_09525	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND440_09545	COG1278	Cold shock
ND440_09550	COG1278	Cold shock
ND440_09555	COG1278	Cold shock
ND440_09570	COG2169	Transcriptional regulator
ND440_09570	COG1917	Cupin 2, conserved barrel domain protein
ND440_09575	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND440_09580	COG2723	6-phospho-beta-galactosidase activity
ND440_09585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND440_09590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND440_09595	COG1187	pseudouridine synthase activity
ND440_09605	COG3122	Protein conserved in bacteria
ND440_09610	COG1757	Na H antiporter
ND440_09640	COG0076	glutamate decarboxylase activity
ND440_09645	COG0531	amino acid
ND440_09680	COG2153	protein acetylation
ND440_09685	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND440_09715	COG0840	transmembrane signaling receptor activity
ND440_09720	COG2801	Transposase and inactivated derivatives
ND440_09845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND440_09850	COG0322	excinuclease ABC activity
ND440_09855	COG2197	response regulator
ND440_09880	COG1113	amino acid transport
ND440_09890	COG0531	amino acid
ND440_09895	COG3710	Transcriptional regulator
ND440_09900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND440_09905	COG0506	proline dehydrogenase activity
ND440_09905	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND440_09905	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND440_09910	COG1126	abc transporter atp-binding protein
ND440_09915	COG0765	amino acid transport
ND440_09920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND440_09925	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND440_09935	COG1191	sigma factor activity
ND440_09975	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND440_09980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND440_09995	COG1677	Flagellar hook-basal body complex protein FliE
ND440_10005	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND440_10015	COG1157	protein secretion by the type III secretion system
ND440_10030	COG1580	Controls the rotational direction of flagella during chemotaxis
ND440_10110	COG1558	bacterial-type flagellum-dependent cell motility
ND440_10115	COG1815	bacterial-type flagellum-dependent cell motility
ND440_10125	COG2747	anti-sigma28 factor FlgM
ND440_10130	COG3418	PFAM FlgN family protein
ND440_10140	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND440_10145	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND440_10150	COG1404	Belongs to the peptidase S8 family
ND440_10150	COG4935	Belongs to the peptidase S8 family
ND440_10155	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND440_10160	COG0745	RESPONSE REGULATOR receiver
ND440_10170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND440_10175	COG0840	transmembrane signaling receptor activity
ND440_10180	COG0840	transmembrane signaling receptor activity
ND440_10185	COG0835	chemotaxis
ND440_10190	COG2198	Histidine kinase
ND440_10190	COG0643	Histidine kinase
ND440_10195	COG1360	Flagellar Motor Protein
ND440_10215	COG0589	response to stress
ND440_10220	COG1285	pathogenesis
ND440_10225	COG0840	transmembrane signaling receptor activity
ND440_10240	COG1609	Transcriptional regulator
ND440_10250	COG1028	Short-chain dehydrogenase reductase Sdr
ND440_10250	COG3321	synthase
ND440_10250	COG0604	alcohol dehydrogenase
ND440_10305	COG0471	metal ion transport
ND440_10320	COG3051	citrate lyase alpha subunit
ND440_10325	COG2301	Belongs to the HpcH HpaI aldolase family
ND440_10330	COG3052	prosthetic group binding
ND440_10335	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND440_10340	COG3290	protein histidine kinase activity
ND440_10345	COG4565	transcriptional regulatory protein
ND440_10360	COG2271	Major facilitator Superfamily
ND440_10365	COG1840	ABC-type Fe3 transport system, periplasmic component
ND440_10375	COG3842	ATPase activity
ND440_10395	COG1289	transmembrane transporter activity
ND440_10405	COG2925	Exonuclease
ND440_10410	COG0531	amino acid
ND440_10415	COG4771	TonB-dependent receptor
ND440_10425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND440_10435	COG0833	amino acid
ND440_10440	COG0583	DNA-binding transcription factor activity
ND440_10450	COG2855	membrane
ND440_10455	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND440_10460	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND440_10460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND440_10460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND440_10465	COG1105	Belongs to the carbohydrate kinase PfkB family
ND440_10480	COG3005	denitrification pathway
ND440_10485	COG0243	molybdopterin cofactor binding
ND440_10500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND440_10510	COG0246	Mannitol dehydrogenase
ND440_10520	COG0523	cobalamin synthesis protein
ND440_10525	COG0671	phosphoesterase, PA-phosphatase related
ND440_10530	COG0791	NLP P60 protein
ND440_10535	COG2200	EAL domain
ND440_10540	COG4166	transmembrane transport
ND440_10545	COG4174	ABC transporter (Permease)
ND440_10550	COG4239	(ABC) transporter, permease
ND440_10555	COG4172	Belongs to the ABC transporter superfamily
ND440_10565	COG2814	Major facilitator Superfamily
ND440_10570	COG1187	pseudouridine synthase activity
ND440_10575	COG1061	Type III restriction enzyme res subunit
ND440_10590	COG3082	Protein of unknown function (DUF1414)
ND440_10595	COG3083	sulfuric ester hydrolase activity
ND440_10620	COG3778	Protein conserved in bacteria
ND440_10625	COG3299	homolog of phage Mu protein gp47
ND440_10670	COG4386	tail sheath protein
ND440_10720	COG1802	Transcriptional regulator
ND440_10720	COG4626	Terminase
ND440_10745	COG1876	peptidase activity
ND440_10775	COG0515	serine threonine protein kinase
ND440_10775	COG2815	serine threonine protein kinase
ND440_10790	COG1403	HNH endonuclease
ND440_10805	COG4725	Belongs to the MT-A70-like family
ND440_10810	COG1802	Transcriptional regulator
ND440_10810	COG4626	Terminase
ND440_10845	COG5532	Uncharacterized conserved protein (DUF2303)
ND440_10850	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND440_10900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND440_10905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND440_10925	COG2223	nitrite transmembrane transporter activity
ND440_10930	COG2198	Histidine kinase
ND440_10930	COG0642	Histidine kinase
ND440_10940	COG0784	Response regulator, receiver
ND440_10940	COG2205	protein histidine kinase activity
ND440_10950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND440_10955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND440_10965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND440_10975	COG4574	serine-type endopeptidase inhibitor activity
ND440_10985	COG2246	polysaccharide biosynthetic process
ND440_11000	COG0814	amino acid
ND440_11025	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND440_11030	COG0596	Alpha beta hydrolase
ND440_11035	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND440_11040	COG1169	isochorismate synthase
ND440_11045	COG4575	ribosome binding
ND440_11060	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND440_11065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND440_11075	COG0839	Belongs to the complex I subunit 6 family
ND440_11080	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND440_11085	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND440_11090	COG1034	ATP synthesis coupled electron transport
ND440_11110	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND440_11115	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND440_11120	COG0583	DNA-binding transcription factor activity
ND440_11125	COG0436	Aminotransferase
ND440_11130	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND440_11135	COG0490	domain, Protein
ND440_11135	COG0471	metal ion transport
ND440_11145	COG3013	Belongs to the UPF0304 family
ND440_11150	COG3092	negative regulation of chromosome organization
ND440_11160	COG0280	phosphate acetyltransferase
ND440_11160	COG0857	belongs to the CobB CobQ family
ND440_11165	COG1609	Transcriptional regulator
ND440_11180	COG3037	sugar-specific permease SgaT UlaA
ND440_11185	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND440_11190	COG0622	Phosphoesterase
ND440_11200	COG0625	glutathione transferase activity
ND440_11205	COG1090	epimerase
ND440_11215	COG4160	amino acid transport
ND440_11220	COG4215	(ABC) transporter
ND440_11235	COG0163	prenyltransferase activity
ND440_11240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND440_11245	COG1286	toxin biosynthetic process
ND440_11250	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND440_11255	COG0285	dihydrofolate synthase activity
ND440_11265	COG0586	Pfam SNARE associated Golgi protein
ND440_11275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND440_11300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND440_11305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND440_11335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND440_11350	COG3101	peptidyl-lysine hydroxylation
ND440_11355	COG0730	response to heat
ND440_11360	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND440_11370	COG2890	protein-(glutamine-N5) methyltransferase activity
ND440_11375	COG2840	Smr protein MutS2
ND440_11380	COG2062	phosphohistidine phosphatase, SixA
ND440_11385	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND440_11385	COG1024	Enoyl-CoA hydratase
ND440_11390	COG0183	Belongs to the thiolase family
ND440_11395	COG3691	Protein conserved in bacteria
ND440_11410	COG3088	subunit of a heme lyase
ND440_11410	COG4235	cytochrome complex assembly
ND440_11415	COG4235	cytochrome complex assembly
ND440_11415	COG3088	subunit of a heme lyase
ND440_11420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND440_11425	COG1138	Cytochrome C-type biogenesis protein
ND440_11430	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND440_11435	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND440_11440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND440_11445	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND440_11465	COG2824	Alkylphosphonate utilization operon protein PhnA
ND440_11470	COG2951	lytic endotransglycosylase activity
ND440_11485	COG3038	cytochrome b561
ND440_11510	COG3275	phosphorelay sensor kinase activity
ND440_11515	COG3279	Response regulator of the LytR AlgR family
ND440_11520	COG2223	nitrite transmembrane transporter activity
ND440_11525	COG0837	glucose binding
ND440_11545	COG1914	H( )-stimulated, divalent metal cation uptake system
ND440_11550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND440_11620	COG3530	Putative quorum-sensing-regulated virulence factor
ND440_11625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND440_11635	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND440_11645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND440_11660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND440_11670	COG4208	sulfate ABC transporter
ND440_11675	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND440_11680	COG4150	thiosulfate binding
ND440_11690	COG1737	Transcriptional regulator
ND440_11695	COG2731	YhcH YjgK YiaL family protein
ND440_11710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND440_11715	COG2837	iron assimilation
ND440_11725	COG3111	PFAM Bacterial OB fold (BOF) protein
ND440_11820	COG1671	Belongs to the UPF0178 family
ND440_11825	COG0281	malic enzyme
ND440_11825	COG0280	phosphate acetyltransferase
ND440_11835	COG3005	denitrification pathway
ND440_11840	COG3043	anaerobic respiration
ND440_11845	COG0243	molybdopterin cofactor binding
ND440_11850	COG3062	negative regulation of establishment of protein localization
ND440_11855	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND440_11855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND440_11860	COG2197	response regulator
ND440_11870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND440_11880	COG1605	Chorismate mutase
ND440_11885	COG1393	Belongs to the ArsC family
ND440_11890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND440_11895	COG1876	peptidase activity
ND440_11905	COG0400	carboxylic ester hydrolase activity
ND440_11925	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND440_11930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND440_11935	COG2716	regulation of RNA biosynthetic process
ND440_11940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND440_11945	COG0628	permease
ND440_11950	COG4783	chaperone-mediated protein folding
ND440_11955	COG1393	Belongs to the ArsC family
ND440_11960	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND440_11965	COG2233	PERMEase
ND440_11970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND440_11975	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND440_11980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND440_11985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND440_11995	COG0581	inorganic phosphate transmembrane transporter activity
ND440_12000	COG0573	inorganic phosphate transmembrane transporter activity
ND440_12005	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND440_12020	COG2239	Acts as a magnesium transporter
ND440_12025	COG0443	Heat shock 70 kDa protein
ND440_12035	COG3121	Chaperone
ND440_12050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND440_12060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND440_12065	COG0477	Major facilitator Superfamily
ND440_12070	COG2205	protein histidine kinase activity
ND440_12075	COG0745	RESPONSE REGULATOR receiver
ND440_12080	COG3422	double-strand break repair
ND440_12085	COG0826	peptidase U32
ND440_12090	COG1597	lipid kinase activity
ND440_12105	COG0351	phosphomethylpyrimidine kinase
ND440_12115	COG0519	Catalyzes the synthesis of GMP from XMP
ND440_12115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND440_12120	COG0517	IMP dehydrogenase activity
ND440_12120	COG0516	GMP reductase activity
ND440_12125	COG1570	exodeoxyribonuclease VII activity
ND440_12130	COG1645	bacterial-type flagellum-dependent swarming motility
ND440_12140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND440_12145	COG2976	Protein conserved in bacteria
ND440_12150	COG0124	histidyl-tRNA synthetase
ND440_12170	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND440_12185	COG4953	penicillin-binding protein 1C
ND440_12190	COG2373	Large extracellular alpha-helical protein
ND440_12205	COG2975	iron-sulfur cluster assembly
ND440_12210	COG0633	Ferredoxin
ND440_12215	COG0443	Heat shock 70 kDa protein
ND440_12230	COG0822	iron-sulfur transferase activity
ND440_12240	COG1959	2 iron, 2 sulfur cluster binding
ND440_12245	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND440_12255	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND440_12260	COG3683	transport system, periplasmic component
ND440_12265	COG3711	transcriptional antiterminator
ND440_12270	COG2814	Major facilitator Superfamily
ND440_12280	COG1017	nitric oxide dioxygenase activity
ND440_12280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND440_12285	COG2188	Transcriptional regulator
ND440_12295	COG3457	Alanine racemase
ND440_12300	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND440_12315	COG0347	Belongs to the P(II) protein family
ND440_12320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND440_12320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND440_12325	COG2204	response regulator
ND440_12330	COG3170	Tfp pilus assembly protein FimV
ND440_12335	COG2205	protein histidine kinase activity
ND440_12350	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND440_12360	COG0560	Phosphoserine phosphatase
ND440_12365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND440_12365	COG1263	PTS System
ND440_12375	COG1737	Transcriptional regulator
ND440_12380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND440_12390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND440_12400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND440_12415	COG0481	GTPase activity
ND440_12420	COG3086	response to oxidative stress
ND440_12430	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND440_12440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND440_12450	COG0513	Belongs to the DEAD box helicase family
ND440_12465	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND440_12475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND440_12480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND440_12485	COG0497	DNA recombination
ND440_12490	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND440_12500	COG2867	negative regulation of translational initiation
ND440_12505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND440_12515	COG0582	viral genome integration into host DNA
ND440_12540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND440_12550	COG1122	ATPase activity
ND440_12605	COG1069	ribulokinase activity
ND440_12615	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND440_12620	COG1129	ABC transporter
ND440_12640	COG1620	l-lactate permease
ND440_12645	COG1304	FMN binding
ND440_12650	COG0579	oxidoreductase
ND440_12655	COG1278	Cold shock
ND440_12685	COG1780	Probably involved in ribonucleotide reductase function
ND440_12690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND440_12700	COG4175	Glycine betaine
ND440_12705	COG4176	ABC-type proline glycine betaine transport system permease component
ND440_12710	COG2113	Glycine betaine
ND440_12715	COG2814	Major facilitator Superfamily
ND440_12720	COG1846	Transcriptional regulator
ND440_12730	COG1566	PFAM secretion protein HlyD family protein
ND440_12735	COG2814	Major facilitator Superfamily
ND440_12740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND440_12745	COG3118	belongs to the thioredoxin family
ND440_12750	COG3148	PFAM DTW domain containing protein
ND440_12755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND440_12755	COG1042	CoA-binding domain protein
ND440_12755	COG0045	succinate-CoA ligase (ADP-forming) activity
ND440_12760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND440_12765	COG5544	Lipoprotein
ND440_12795	COG0542	response to heat
ND440_12800	COG1496	oxidoreductase activity
ND440_12805	COG0564	pseudouridine synthase activity
ND440_12810	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND440_12815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND440_12825	COG0077	Prephenate dehydratase
ND440_12825	COG1605	Chorismate mutase
ND440_12830	COG0287	Prephenate dehydrogenase
ND440_12830	COG1605	Chorismate mutase
ND440_12835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND440_12840	COG3279	Response regulator of the LytR AlgR family
ND440_12845	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND440_12850	COG3137	Salt-induced outer membrane protein
ND440_12855	COG0335	large ribosomal subunit rRNA binding
ND440_12860	COG0336	Belongs to the RNA methyltransferase TrmD family
ND440_12865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND440_12875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND440_12880	COG4137	Cytochrome C assembly protein
ND440_12885	COG4536	flavin adenine dinucleotide binding
ND440_12890	COG1854	S-ribosylhomocysteine lyase activity
ND440_12895	COG2918	glutathione biosynthetic process
ND440_12900	COG1238	metal cluster binding
ND440_12905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND440_12935	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND440_12940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND440_12945	COG2137	regulation of response to DNA damage stimulus
ND440_12950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND440_12965	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND440_12965	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND440_12990	COG3031	protein transport across the cell outer membrane
ND440_13000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND440_13045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ND440_13055	COG3397	chitin binding
ND440_13075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND440_13225	COG0784	Response regulator, receiver
ND440_13225	COG2205	protein histidine kinase activity
ND440_13300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND440_13305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND440_13310	COG1388	LysM domain
ND440_13310	COG4942	peptidase
ND440_13320	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND440_13325	COG0585	pseudouridine synthase activity
ND440_13330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND440_13340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND440_13350	COG0529	Catalyzes the synthesis of activated sulfate
ND440_13355	COG2895	sulfate adenylyltransferase (ATP) activity
ND440_13360	COG0175	sulfate reduction
ND440_13365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND440_13365	COG1648	precorrin-2 dehydrogenase activity
ND440_13370	COG2234	aminopeptidase activity
ND440_13385	COG0175	sulfate reduction
ND440_13395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND440_13400	COG0720	synthase
ND440_13410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ND440_13480	COG4386	tail sheath protein
ND440_13505	COG4397	Mu-like prophage major head subunit gpT
ND440_13530	COG4383	Mu-like prophage protein gp29
ND440_13585	COG4382	Mu-like prophage protein Gp16
ND440_13650	COG3423	Transcriptional regulator
ND440_13670	COG0504	CTP synthase activity
ND440_13675	COG3956	TIGRFAM MazG family protein
ND440_13680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND440_13685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND440_13695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND440_13700	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND440_13705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND440_13715	COG2860	membrane
ND440_13720	COG0316	Belongs to the HesB IscA family
ND440_13730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND440_13735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND440_13740	COG1643	Atp-dependent helicase
ND440_13745	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND440_13750	COG1489	DNA binding
ND440_13765	COG0617	tRNA 3'-terminal CCA addition
ND440_13770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND440_13775	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND440_13780	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND440_13785	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND440_13790	COG0726	polysaccharide deacetylase
ND440_13795	COG0842	Transport permease protein
ND440_13800	COG1131	(ABC) transporter
ND440_13805	COG0288	reversible hydration of carbon dioxide
ND440_13815	COG2132	Multicopper oxidase
ND440_13825	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND440_13840	COG3112	Uncharacterised protein family (UPF0231)
ND440_13845	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND440_13855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND440_13860	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND440_13865	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND440_13870	COG2186	Transcriptional regulator
ND440_13875	COG1113	amino acid transport
ND440_13880	COG3725	Membrane protein required for beta-lactamase induction
ND440_13895	COG4969	Belongs to the N-Me-Phe pilin family
ND440_13900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND440_13905	COG1459	type II secretion system
ND440_13910	COG0516	GMP reductase activity
ND440_13930	COG0494	nUDIX hydrolase
ND440_13955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND440_13960	COG0849	cell division
ND440_13965	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND440_13975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND440_13980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND440_13985	COG0772	Belongs to the SEDS family
ND440_14000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND440_14005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND440_14010	COG0768	penicillin binding
ND440_14015	COG3116	cell division
ND440_14020	COG0275	rRNA processing
ND440_14040	COG0675	Transposase, IS605 OrfB family
ND440_14055	COG0028	Belongs to the TPP enzyme family
ND440_14060	COG1022	Amp-dependent synthetase and ligase
ND440_14075	COG0473	3-isopropylmalate dehydrogenase activity
ND440_14080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND440_14090	COG2814	Major facilitator Superfamily
ND440_14105	COG4143	(ABC) transporter
ND440_14110	COG1178	ABC-type Fe3 transport system permease component
ND440_14120	COG0586	Pfam SNARE associated Golgi protein
ND440_14125	COG0417	DNA replication proofreading
ND440_14130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND440_14135	COG0564	pseudouridine synthase activity
ND440_14145	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND440_14155	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND440_14160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND440_14165	COG2967	ApaG domain
ND440_14190	COG2966	Psort location CytoplasmicMembrane, score
ND440_14200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND440_14215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND440_14220	COG1047	Peptidyl-prolyl cis-trans
ND440_14225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND440_14235	COG0196	riboflavin kinase activity
ND440_14245	COG0583	DNA-binding transcription factor activity
ND440_14250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND440_14260	COG0443	Heat shock 70 kDa protein
ND440_14265	COG1584	GPR1 FUN34 yaaH family protein
ND440_14275	COG0477	Major facilitator Superfamily
ND440_14280	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND440_14285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND440_14320	COG0745	RESPONSE REGULATOR receiver
ND440_14325	COG3045	CreA protein
ND440_14330	COG2207	Transcriptional regulator
ND440_14330	COG3708	Transcriptional regulator
ND440_14335	COG0406	alpha-ribazole phosphatase activity
ND440_14340	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND440_14345	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND440_14350	COG0741	lytic transglycosylase activity
ND440_14370	COG0488	(ABC) transporter
ND440_14385	COG0560	Phosphoserine phosphatase
ND440_14390	COG3726	membrane protein affecting hemolysin expression
ND440_14400	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND440_14415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND440_14420	COG0084	hydrolase, TatD family'
ND440_14425	COG4667	esterase of the alpha-beta hydrolase superfamily
ND440_14435	COG2823	Periplasmic or secreted lipoprotein
ND440_14450	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND440_14490	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND440_14490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND440_14490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND440_14495	COG1461	Dihydroxyacetone kinase
ND440_14500	COG2376	Dihydroxyacetone kinase
ND440_14510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND440_14515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND440_14530	COG0859	PFAM glycosyl transferase family 9
ND440_14555	COG3119	arylsulfatase activity
ND440_14560	COG0641	radical SAM
ND440_14570	COG1028	Short-chain dehydrogenase reductase Sdr
ND440_14580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND440_14590	COG3716	PTS system mannose fructose sorbose family IID component
ND440_14595	COG3715	PTS system
ND440_14600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND440_14605	COG2222	sugar isomerase
ND440_14615	COG1349	DNA-binding transcription factor activity
ND440_14620	COG3119	arylsulfatase activity
ND440_14640	COG5492	domain, Protein
ND440_14730	COG3077	Addiction module antitoxin, RelB DinJ family
ND440_14745	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ND440_14750	COG0732	type I restriction modification DNA specificity domain
ND440_14755	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ND440_14795	COG0795	lipopolysaccharide-transporting ATPase activity
ND440_14800	COG0795	lipopolysaccharide-transporting ATPase activity
ND440_14805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND440_14810	COG2927	DNA polymerase III (CHI subunit)
ND440_14825	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND440_14845	COG3624	Phosphonate C-P lyase system protein PhnG
ND440_14850	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND440_14855	COG3626	phosphonate metabolism
ND440_14860	COG3627	carbon phosphorus lyase activity
ND440_14865	COG4107	phosphonate C-P lyase system protein PhnK
ND440_14870	COG4778	phosphonate C-P lyase system protein PhnL
ND440_14875	COG3454	Phosphonate metabolism
ND440_14880	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND440_14885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND440_14890	COG0702	epimerase
ND440_14895	COG3787	Belongs to the UPF0306 family
ND440_14905	COG1982	Orn Lys Arg decarboxylase major
ND440_14910	COG0531	amino acid
ND440_14915	COG2827	Endonuclease containing a URI domain
ND440_14920	COG3153	acetyltransferase
ND440_14925	COG3154	lipid carrier protein
ND440_14930	COG0826	peptidase U32
ND440_14935	COG0826	peptidase U32
ND440_14945	COG0814	amino acid
ND440_14950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND440_14955	COG0513	Belongs to the DEAD box helicase family
ND440_14965	COG1185	polyribonucleotide nucleotidyltransferase activity
ND440_14980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND440_14990	COG0195	Participates in both transcription termination and antitermination
ND440_15010	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND440_15015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND440_15020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND440_15030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND440_15035	COG1534	Rna-binding protein
ND440_15045	COG2027	D-alanyl-D-alanine carboxypeptidase
ND440_15050	COG0745	RESPONSE REGULATOR receiver
ND440_15055	COG0642	Histidine kinase
ND440_15060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND440_15065	COG0697	spore germination
ND440_15080	COG0142	geranyltranstransferase activity
ND440_15095	COG3423	Transcriptional regulator
ND440_15110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND440_15120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND440_15125	COG2105	PFAM AIG2 family protein
ND440_15130	COG2911	Protein conserved in bacteria
ND440_15135	COG0729	surface antigen
ND440_15140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND440_15145	COG1253	flavin adenine dinucleotide binding
ND440_15155	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND440_15160	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND440_15165	COG0737	Belongs to the 5'-nucleotidase family
ND440_15175	COG0545	Peptidyl-prolyl cis-trans isomerase
ND440_15180	COG3061	Opacity-associated protein A
ND440_15185	COG0359	binds to the 23S rRNA
ND440_15190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND440_15195	COG2965	DNA replication, synthesis of RNA primer
ND440_15200	COG0360	Binds together with S18 to 16S ribosomal RNA
ND440_15210	COG1073	alpha beta
ND440_15230	COG3188	usher protein
ND440_15235	COG3121	Chaperone
ND440_15255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND440_15260	COG0557	exoribonuclease II activity
ND440_15265	COG1959	2 iron, 2 sulfur cluster binding
ND440_15270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND440_15275	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND440_15280	COG0330	HflC and HflK could
ND440_15285	COG0330	HflC and HflK could
ND440_15290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND440_15300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND440_15310	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND440_15315	COG0802	atpase or kinase
ND440_15320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND440_15320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND440_15325	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND440_15345	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND440_15350	COG1162	GTPase activity
ND440_15355	COG0688	phosphatidylethanolamine metabolic process
ND440_15360	COG3264	Mechanosensitive ion channel
ND440_15360	COG1511	domain protein
ND440_15365	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND440_15370	COG1053	succinate dehydrogenase
ND440_15375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND440_15380	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND440_15385	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND440_15405	COG3188	usher protein
ND440_15425	COG3397	chitin binding
ND440_15435	COG1509	lysine 2,3-aminomutase activity
ND440_15465	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND440_15475	COG4232	protein-disulfide reductase activity
ND440_15480	COG1309	transcriptional regulator
ND440_15500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND440_15520	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ND440_15525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND440_15525	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND440_15545	COG1028	Short-chain dehydrogenase reductase Sdr
ND440_15550	COG1083	cytidylyl-transferase
ND440_15550	COG2755	lipolytic protein G-D-S-L family
ND440_15570	COG2089	acid synthase
ND440_15575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND440_15580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND440_15585	COG1086	Polysaccharide biosynthesis protein
ND440_15590	COG0425	Belongs to the sulfur carrier protein TusA family
ND440_15595	COG2391	methyltransferase activity
ND440_15600	COG1301	dicarboxylic acid transport
ND440_15605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND440_15610	COG3162	membrane
ND440_15615	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND440_15645	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND440_15650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND440_15655	COG1739	Uncharacterized protein family UPF0029
ND440_15665	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND440_15665	COG1024	Enoyl-CoA hydratase
ND440_15675	COG0543	2 iron, 2 sulfur cluster binding
ND440_15690	COG0250	Participates in transcription elongation, termination and antitermination
ND440_15705	COG0805	protein transport
ND440_15710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND440_15715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND440_15720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND440_15725	COG3165	ubiquinone biosynthetic process from chorismate
ND440_15730	COG2226	methyltransferase
ND440_15735	COG1322	Protein conserved in bacteria
ND440_15740	COG0586	Pfam SNARE associated Golgi protein
ND440_15745	COG1966	Carbon starvation protein
ND440_15760	COG0412	Dienelactone hydrolase
ND440_15765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND440_15770	COG0583	DNA-binding transcription factor activity
ND440_15775	COG0697	spore germination
ND440_15785	COG0584	glycerophosphoryl diester phosphodiesterase
ND440_15795	COG0395	ABC-type sugar transport system, permease component
ND440_15800	COG1175	transmembrane transport
ND440_15805	COG1653	transport
ND440_15840	COG0410	ABC transporter
ND440_15850	COG4177	L-phenylalanine transmembrane transporter activity
ND440_15870	COG1929	Belongs to the glycerate kinase type-1 family
ND440_15875	COG2610	gluconate transmembrane transporter activity
ND440_15880	COG3835	regulator
ND440_15890	COG2177	Part of the ABC transporter FtsEX involved in
ND440_15895	COG2884	Cell division ATP-binding protein ftsE
ND440_15900	COG0552	protein localization to endoplasmic reticulum
ND440_15900	COG0552	protein localization to endoplasmic reticulum
ND440_15905	COG0742	ribosomal rna small subunit methyltransferase
ND440_15910	COG3776	membrane
ND440_15925	COG3714	YhhN family
ND440_15940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND440_15950	COG0247	lactate metabolic process
ND440_15960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND440_15970	COG2271	Major facilitator Superfamily
ND440_15975	COG0584	glycerophosphoryl diester phosphodiesterase
ND440_15980	COG0561	phosphatase activity
ND440_15985	COG2267	carboxylic ester hydrolase activity
ND440_15990	COG1280	lysine exporter protein (LysE YggA)
ND440_15995	COG0514	ATP-dependent DNA helicase (RecQ)
ND440_16000	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND440_16005	COG2050	protein possibly involved in aromatic compounds catabolism
ND440_16025	COG5564	TIM-barrel signal transduction protein
ND440_16030	COG5441	Belongs to the UPF0261 family
ND440_16040	COG0210	DNA helicase
ND440_16045	COG1011	Hydrolase
ND440_16050	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND440_16055	COG3159	Protein conserved in bacteria
ND440_16060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND440_16065	COG5567	small periplasmic lipoprotein
ND440_16075	COG3072	Adenylate cyclase
ND440_16080	COG0181	hydroxymethylbilane synthase activity
ND440_16085	COG1587	Uroporphyrinogen-III synthase
ND440_16090	COG2959	enzyme of heme biosynthesis
ND440_16095	COG3071	HemY protein
ND440_16140	COG2244	polysaccharide biosynthetic process
ND440_16145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND440_16150	COG0456	acetyltransferase
ND440_16155	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND440_16160	COG1088	dTDP-glucose 4,6-dehydratase activity
ND440_16165	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND440_16170	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND440_16175	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND440_16180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND440_16185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND440_16190	COG3118	belongs to the thioredoxin family
ND440_16200	COG0248	Ppx GppA phosphatase
ND440_16210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND440_16225	COG3397	chitin binding
ND440_16235	COG0129	dihydroxy-acid dehydratase activity
ND440_16245	COG3978	acetolactate synthase activity
ND440_16265	COG3085	chromosome segregation
ND440_16270	COG0583	DNA-binding transcription factor activity
ND440_16350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND440_16360	COG0678	peroxiredoxin activity
ND440_16360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND440_16365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND440_16400	COG1629	transport
ND440_16405	COG0165	Argininosuccinate lyase
ND440_16410	COG0137	argininosuccinate synthase activity
ND440_16415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND440_16460	COG0460	homoserine dehydrogenase
ND440_16460	COG0527	aspartate kinase activity
ND440_16465	COG0626	cystathionine gamma-synthase activity
ND440_16470	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND440_16480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND440_16485	COG1609	Transcriptional regulator
ND440_16490	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND440_16495	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND440_16500	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND440_16505	COG1575	Belongs to the MenA family. Type 1 subfamily
ND440_16510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND440_16515	COG3074	FtsZ-dependent cytokinesis
ND440_16520	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND440_16525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND440_16530	COG1494	fructose-1,6-bisphosphatase
ND440_16535	COG2814	Major facilitator Superfamily
ND440_16545	COG3152	Membrane
ND440_16560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND440_16570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND440_16575	COG3678	ATP-independent chaperone mediated protein folding
ND440_16580	COG0745	RESPONSE REGULATOR receiver
ND440_16585	COG2205	protein histidine kinase activity
ND440_16590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND440_16595	COG1045	serine acetyltransferase
ND440_16600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND440_16605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND440_16610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND440_16615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND440_16620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND440_16625	COG4942	peptidase
ND440_16630	COG2861	carbohydrate metabolic process
ND440_16645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND440_16650	COG0859	PFAM glycosyl transferase family 9
ND440_16655	COG0859	PFAM glycosyl transferase family 9
ND440_16660	COG1519	Transferase
ND440_16680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND440_16685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND440_16690	COG2003	Belongs to the UPF0758 family
ND440_16695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND440_16700	COG0756	dUTP diphosphatase activity
ND440_16705	COG1309	transcriptional regulator
ND440_16710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND440_16715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND440_16720	COG1561	YicC-like family, N-terminal region
ND440_16765	COG5001	Diguanylate cyclase
ND440_16770	COG1024	Enoyl-CoA hydratase
ND440_16775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND440_16785	COG2860	membrane
ND440_16790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND440_16800	COG1758	RNA polymerase activity
ND440_16805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND440_16810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND440_16815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND440_16820	COG0786	glutamate:sodium symporter activity
ND440_16825	COG2233	PERMEase
ND440_16830	COG2982	Protein involved in outer membrane biogenesis
ND440_16835	COG0456	acetyltransferase
ND440_16850	COG1011	Hydrolase
ND440_16865	COG3852	Histidine kinase
ND440_16875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND440_16885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND440_16890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND440_16890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND440_16895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND440_16900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND440_16905	COG3084	Protein conserved in bacteria
ND440_16915	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND440_16940	COG2186	Transcriptional regulator
ND440_16945	COG1609	Transcriptional regulator
ND440_16950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND440_16960	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND440_16965	COG1129	ABC transporter
ND440_16970	COG1869	D-ribose catabolic process
ND440_16975	COG3158	transport of potassium into the cell
ND440_16980	COG0714	Associated with various cellular activities
ND440_16985	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND440_16995	COG2502	aspartate--ammonia ligase
ND440_17000	COG1522	sequence-specific DNA binding
ND440_17005	COG0716	FMN binding
ND440_17010	COG0445	tRNA wobble uridine modification
ND440_17015	COG0357	Ribosomal RNA small subunit methyltransferase G
ND440_17020	COG3312	ion transport
ND440_17025	COG0356	it plays a direct role in the translocation of protons across the membrane
ND440_17035	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND440_17045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND440_17050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND440_17060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND440_17075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND440_17080	COG0573	inorganic phosphate transmembrane transporter activity
ND440_17085	COG0581	inorganic phosphate transmembrane transporter activity
ND440_17095	COG0704	Plays a role in the regulation of phosphate uptake
ND440_17100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND440_17105	COG0765	amino acid transport
ND440_17110	COG0765	amino acid transport
ND440_17115	COG2252	PERMEase
ND440_17120	COG0840	transmembrane signaling receptor activity
ND440_17130	COG3121	Chaperone
ND440_17145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND440_17150	COG0706	membrane insertase activity
ND440_17160	COG0594	ribonuclease P activity
ND440_17165	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ND440_17170	COG2205	protein histidine kinase activity
ND440_17170	COG3437	response regulator, receiver
ND440_17170	COG3850	Histidine kinase
ND440_17170	COG4999	Histidine kinase
ND440_17260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND440_17275	COG3549	Plasmid maintenance system killer
ND440_17280	COG3093	addiction module antidote protein HigA
ND440_17590	COG3344	reverse transcriptase