locus-tag	class	description
ND449_00010	COG0592	DNA-directed DNA polymerase activity
ND449_00020	COG0187	DNA topoisomerase II activity
ND449_00025	COG0561	phosphatase activity
ND449_00030	COG0823	Involved in the tonB-independent uptake of proteins
ND449_00035	COG5645	(Lipo)protein
ND449_00050	COG0569	domain protein
ND449_00050	COG2985	domain, Protein
ND449_00055	COG3977	Valine--pyruvate aminotransferase
ND449_00060	COG2885	chlorophyll binding
ND449_00080	COG2818	Glycosylase
ND449_00130	COG2213	PTS system mannitol-specific
ND449_00130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND449_00140	COG3722	fumarate hydratase activity
ND449_00150	COG2258	MOSC domain
ND449_00155	COG0840	transmembrane signaling receptor activity
ND449_00160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND449_00175	COG0437	4 iron, 4 sulfur cluster binding
ND449_00180	COG2864	formate dehydrogenase
ND449_00190	COG1921	L-seryl-tRNASec selenium transferase activity
ND449_00195	COG3276	selenocysteine insertion sequence binding
ND449_00200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND449_00210	COG3274	enterobacterial common antigen metabolic process
ND449_00220	COG0582	viral genome integration into host DNA
ND449_00255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND449_00260	COG2986	histidine ammonia-lyase
ND449_00280	COG2194	sulfuric ester hydrolase activity
ND449_00285	COG2197	response regulator
ND449_00290	COG3851	Histidine kinase
ND449_00295	COG2271	Major facilitator Superfamily
ND449_00305	COG0747	negative chemotaxis
ND449_00310	COG0601	transmembrane transport
ND449_00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND449_00320	COG0444	Belongs to the ABC transporter superfamily
ND449_00325	COG4608	Belongs to the ABC transporter superfamily
ND449_00330	COG2194	sulfuric ester hydrolase activity
ND449_00355	COG1215	transferase activity, transferring glycosyl groups
ND449_00360	COG1215	transferase activity, transferring glycosyl groups
ND449_00365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND449_00370	COG0457	Tetratricopeptide repeat
ND449_00370	COG3118	belongs to the thioredoxin family
ND449_00375	COG2199	diguanylate cyclase activity
ND449_00375	COG2200	EAL domain
ND449_00380	COG1301	dicarboxylic acid transport
ND449_00385	COG0612	Peptidase, M16
ND449_00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND449_00395	COG1942	4-Oxalocrotonate Tautomerase
ND449_00400	COG2200	EAL domain
ND449_00405	COG2134	cdp-diacylglycerol pyrophosphatase
ND449_00410	COG1295	ribonuclease BN
ND449_00420	COG1301	dicarboxylic acid transport
ND449_00425	COG0626	cystathionine gamma-synthase activity
ND449_00435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND449_00440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND449_00445	COG0339	signal peptide processing
ND449_00450	COG0742	ribosomal rna small subunit methyltransferase
ND449_00460	COG0589	response to stress
ND449_00470	COG0306	phosphate transporter
ND449_00475	COG2081	HI0933 family
ND449_00485	COG1247	-acetyltransferase
ND449_00495	COG1741	Belongs to the pirin family
ND449_00500	COG1609	Transcriptional regulator
ND449_00505	COG2610	gluconate transmembrane transporter activity
ND449_00510	COG3265	gluconokinase activity
ND449_00515	COG2095	MarC family integral membrane protein
ND449_00520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND449_00525	COG3275	phosphorelay sensor kinase activity
ND449_00530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND449_00535	COG1523	belongs to the glycosyl hydrolase 13 family
ND449_00540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND449_00545	COG0297	glycogen (starch) synthase activity
ND449_00550	COG0058	SHG alpha-glucan phosphorylase activity
ND449_00555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND449_00560	COG1349	DNA-binding transcription factor activity
ND449_00565	COG0705	Rhomboid family
ND449_00575	COG2909	trisaccharide binding
ND449_00580	COG0058	SHG alpha-glucan phosphorylase activity
ND449_00585	COG1640	4-alpha-glucanotransferase
ND449_00595	COG1040	competence protein
ND449_00600	COG0596	Alpha beta hydrolase
ND449_00620	COG1918	ferrous iron import across plasma membrane
ND449_00625	COG2183	response to ionizing radiation
ND449_00650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND449_00665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND449_00675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND449_00680	COG1011	Hydrolase
ND449_00690	COG0494	nUDIX hydrolase
ND449_00695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND449_00720	COG4796	Type ii and iii secretion system protein
ND449_00725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND449_00745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND449_00755	COG0180	Tryptophanyl-tRNA synthetase
ND449_00775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND449_00780	COG0402	S-adenosylhomocysteine deaminase activity
ND449_00785	COG0738	Major facilitator superfamily
ND449_00800	COG1609	Transcriptional regulator
ND449_00805	COG1486	melibiose metabolic process
ND449_00810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND449_00825	COG1289	transmembrane transporter activity
ND449_00830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND449_00835	COG1765	OsmC-like protein
ND449_00860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND449_00865	COG3954	Phosphoribulokinase
ND449_00875	COG0429	hydrolase of the alpha beta-hydrolase fold
ND449_00885	COG0859	PFAM glycosyl transferase family 9
ND449_00890	COG1216	Glycosyl transferase, family 2
ND449_00895	COG0488	(ABC) transporter
ND449_00900	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND449_00910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND449_00915	COG1047	Peptidyl-prolyl cis-trans
ND449_00925	COG0545	Peptidyl-prolyl cis-trans isomerase
ND449_00930	COG2964	Protein conserved in bacteria
ND449_00940	COG2923	Belongs to the DsrF TusC family
ND449_00945	COG2168	tRNA wobble position uridine thiolation
ND449_00950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND449_00955	COG0049	tRNA binding
ND449_00965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND449_00980	COG0051	transcription antitermination factor activity, RNA binding
ND449_00985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND449_00995	COG0089	rRNA binding
ND449_01000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND449_01005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND449_01010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND449_01020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND449_01025	COG0255	Belongs to the universal ribosomal protein uL29 family
ND449_01030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND449_01035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND449_01045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND449_01070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND449_01075	COG1841	ribosomal large subunit assembly
ND449_01080	COG0200	Binds to the 23S rRNA
ND449_01085	COG0201	protein transport
ND449_01090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND449_01095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND449_01105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND449_01115	COG0203	ribosomal protein L17
ND449_01120	COG0789	Transcriptional regulator
ND449_01125	COG3036	rescue of stalled ribosome
ND449_01130	COG1970	mechanosensitive ion channel activity
ND449_01140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND449_01140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND449_01145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND449_01150	COG0242	peptide deformylase activity
ND449_01155	COG0758	DNA mediated transformation
ND449_01160	COG2922	Belongs to the Smg family
ND449_01165	COG0551	DNA topoisomerase type I activity
ND449_01170	COG0009	L-threonylcarbamoyladenylate synthase
ND449_01180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND449_01210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND449_01215	COG3162	membrane
ND449_01220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND449_01225	COG1301	dicarboxylic acid transport
ND449_01235	COG2391	methyltransferase activity
ND449_01240	COG0425	Belongs to the sulfur carrier protein TusA family
ND449_01245	COG1086	Polysaccharide biosynthesis protein
ND449_01250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND449_01255	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND449_01260	COG2089	acid synthase
ND449_01280	COG2755	lipolytic protein G-D-S-L family
ND449_01280	COG1083	cytidylyl-transferase
ND449_01285	COG1028	Short-chain dehydrogenase reductase Sdr
ND449_01305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND449_01305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND449_01310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ND449_01330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND449_01350	COG1309	transcriptional regulator
ND449_01355	COG4232	protein-disulfide reductase activity
ND449_01365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND449_01395	COG1509	lysine 2,3-aminomutase activity
ND449_01405	COG3397	chitin binding
ND449_01425	COG3188	usher protein
ND449_01445	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND449_01450	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND449_01455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND449_01460	COG1053	succinate dehydrogenase
ND449_01465	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND449_01470	COG3264	Mechanosensitive ion channel
ND449_01470	COG1511	domain protein
ND449_01475	COG0688	phosphatidylethanolamine metabolic process
ND449_01480	COG1162	GTPase activity
ND449_01485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND449_01505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND449_01510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND449_01510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND449_01515	COG0802	atpase or kinase
ND449_01520	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND449_01530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND449_01540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND449_01545	COG0330	HflC and HflK could
ND449_01550	COG0330	HflC and HflK could
ND449_01555	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND449_01560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND449_01565	COG1959	2 iron, 2 sulfur cluster binding
ND449_01570	COG0557	exoribonuclease II activity
ND449_01575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND449_01595	COG3121	Chaperone
ND449_01600	COG3188	usher protein
ND449_01620	COG1073	alpha beta
ND449_01630	COG0360	Binds together with S18 to 16S ribosomal RNA
ND449_01635	COG2965	DNA replication, synthesis of RNA primer
ND449_01640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND449_01645	COG0359	binds to the 23S rRNA
ND449_01650	COG3061	Opacity-associated protein A
ND449_01655	COG0545	Peptidyl-prolyl cis-trans isomerase
ND449_01665	COG0737	Belongs to the 5'-nucleotidase family
ND449_01670	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND449_01675	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND449_01685	COG1253	flavin adenine dinucleotide binding
ND449_01690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND449_01695	COG0729	surface antigen
ND449_01700	COG2911	Protein conserved in bacteria
ND449_01705	COG2105	PFAM AIG2 family protein
ND449_01710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND449_01720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND449_01735	COG3423	Transcriptional regulator
ND449_01750	COG0142	geranyltranstransferase activity
ND449_01765	COG0697	spore germination
ND449_01770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND449_01775	COG0642	Histidine kinase
ND449_01780	COG0745	RESPONSE REGULATOR receiver
ND449_01785	COG2027	D-alanyl-D-alanine carboxypeptidase
ND449_01795	COG1534	Rna-binding protein
ND449_01800	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND449_01810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND449_01815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND449_01820	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND449_01840	COG0195	Participates in both transcription termination and antitermination
ND449_01850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND449_01865	COG1185	polyribonucleotide nucleotidyltransferase activity
ND449_01875	COG0513	Belongs to the DEAD box helicase family
ND449_01880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND449_01895	COG0826	peptidase U32
ND449_01900	COG0826	peptidase U32
ND449_01905	COG3154	lipid carrier protein
ND449_01910	COG3153	acetyltransferase
ND449_01915	COG2827	Endonuclease containing a URI domain
ND449_01920	COG0531	amino acid
ND449_01925	COG1982	Orn Lys Arg decarboxylase major
ND449_01935	COG3787	Belongs to the UPF0306 family
ND449_01940	COG0702	epimerase
ND449_01945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND449_01950	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND449_01955	COG3454	Phosphonate metabolism
ND449_01960	COG4778	phosphonate C-P lyase system protein PhnL
ND449_01965	COG4107	phosphonate C-P lyase system protein PhnK
ND449_01970	COG3627	carbon phosphorus lyase activity
ND449_01975	COG3626	phosphonate metabolism
ND449_01980	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND449_01985	COG3624	Phosphonate C-P lyase system protein PhnG
ND449_02005	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND449_02020	COG2927	DNA polymerase III (CHI subunit)
ND449_02025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND449_02030	COG0795	lipopolysaccharide-transporting ATPase activity
ND449_02035	COG0795	lipopolysaccharide-transporting ATPase activity
ND449_02075	COG3077	Addiction module antitoxin, RelB DinJ family
ND449_02180	COG5492	domain, Protein
ND449_02200	COG3119	arylsulfatase activity
ND449_02205	COG1349	DNA-binding transcription factor activity
ND449_02215	COG2222	sugar isomerase
ND449_02220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND449_02225	COG3715	PTS system
ND449_02230	COG3716	PTS system mannose fructose sorbose family IID component
ND449_02240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND449_02250	COG1028	Short-chain dehydrogenase reductase Sdr
ND449_02260	COG0641	radical SAM
ND449_02265	COG3119	arylsulfatase activity
ND449_02290	COG0859	PFAM glycosyl transferase family 9
ND449_02305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND449_02310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND449_02320	COG2376	Dihydroxyacetone kinase
ND449_02325	COG1461	Dihydroxyacetone kinase
ND449_02330	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND449_02330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND449_02330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND449_02370	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND449_02385	COG2823	Periplasmic or secreted lipoprotein
ND449_02395	COG4667	esterase of the alpha-beta hydrolase superfamily
ND449_02400	COG0084	hydrolase, TatD family'
ND449_02405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND449_02420	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND449_02430	COG3726	membrane protein affecting hemolysin expression
ND449_02435	COG0560	Phosphoserine phosphatase
ND449_02450	COG0488	(ABC) transporter
ND449_02475	COG0741	lytic transglycosylase activity
ND449_02480	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND449_02485	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND449_02490	COG0406	alpha-ribazole phosphatase activity
ND449_02495	COG2207	Transcriptional regulator
ND449_02495	COG3708	Transcriptional regulator
ND449_02500	COG3045	CreA protein
ND449_02505	COG0745	RESPONSE REGULATOR receiver
ND449_02540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND449_02545	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND449_02550	COG0477	Major facilitator Superfamily
ND449_02560	COG1584	GPR1 FUN34 yaaH family protein
ND449_02565	COG0443	Heat shock 70 kDa protein
ND449_02575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND449_02580	COG0583	DNA-binding transcription factor activity
ND449_02590	COG0196	riboflavin kinase activity
ND449_02600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND449_02605	COG1047	Peptidyl-prolyl cis-trans
ND449_02610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND449_02625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND449_02635	COG2966	Psort location CytoplasmicMembrane, score
ND449_02660	COG2967	ApaG domain
ND449_02665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND449_02670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND449_02680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND449_02690	COG0564	pseudouridine synthase activity
ND449_02695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND449_02700	COG0417	DNA replication proofreading
ND449_02705	COG0586	Pfam SNARE associated Golgi protein
ND449_02715	COG1178	ABC-type Fe3 transport system permease component
ND449_02720	COG4143	(ABC) transporter
ND449_02735	COG2814	Major facilitator Superfamily
ND449_02745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND449_02750	COG0473	3-isopropylmalate dehydrogenase activity
ND449_02765	COG1022	Amp-dependent synthetase and ligase
ND449_02770	COG0028	Belongs to the TPP enzyme family
ND449_02795	COG0275	rRNA processing
ND449_02800	COG3116	cell division
ND449_02805	COG0768	penicillin binding
ND449_02810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND449_02815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND449_02830	COG0772	Belongs to the SEDS family
ND449_02835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND449_02840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND449_02850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND449_02855	COG0849	cell division
ND449_02860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND449_02885	COG0494	nUDIX hydrolase
ND449_02905	COG0516	GMP reductase activity
ND449_02910	COG1459	type II secretion system
ND449_02915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND449_02920	COG4969	Belongs to the N-Me-Phe pilin family
ND449_02935	COG3725	Membrane protein required for beta-lactamase induction
ND449_02940	COG1113	amino acid transport
ND449_02945	COG2186	Transcriptional regulator
ND449_02950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND449_02955	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND449_02960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND449_02970	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND449_02975	COG3112	Uncharacterised protein family (UPF0231)
ND449_02990	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND449_03000	COG2132	Multicopper oxidase
ND449_03010	COG0288	reversible hydration of carbon dioxide
ND449_03015	COG1131	(ABC) transporter
ND449_03020	COG0842	Transport permease protein
ND449_03025	COG0726	polysaccharide deacetylase
ND449_03030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND449_03035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND449_03040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND449_03045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND449_03050	COG0617	tRNA 3'-terminal CCA addition
ND449_03065	COG1489	DNA binding
ND449_03070	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND449_03075	COG1643	Atp-dependent helicase
ND449_03080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND449_03085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND449_03095	COG0316	Belongs to the HesB IscA family
ND449_03100	COG2860	membrane
ND449_03110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND449_03115	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND449_03120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND449_03130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND449_03135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND449_03140	COG3956	TIGRFAM MazG family protein
ND449_03145	COG0504	CTP synthase activity
ND449_03155	COG0602	queuosine metabolic process
ND449_03160	COG0720	synthase
ND449_03165	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND449_03175	COG0175	sulfate reduction
ND449_03190	COG2234	aminopeptidase activity
ND449_03195	COG1648	precorrin-2 dehydrogenase activity
ND449_03195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND449_03200	COG0175	sulfate reduction
ND449_03205	COG2895	sulfate adenylyltransferase (ATP) activity
ND449_03210	COG0529	Catalyzes the synthesis of activated sulfate
ND449_03220	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND449_03230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND449_03235	COG0585	pseudouridine synthase activity
ND449_03240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND449_03250	COG4942	peptidase
ND449_03250	COG1388	LysM domain
ND449_03255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND449_03260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND449_03330	COG2205	protein histidine kinase activity
ND449_03330	COG0784	Response regulator, receiver
ND449_03350	COG0741	lytic transglycosylase activity
ND449_03480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND449_03500	COG3397	chitin binding
ND449_03510	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ND449_03555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND449_03565	COG3031	protein transport across the cell outer membrane
ND449_03590	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND449_03590	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND449_03605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND449_03610	COG2137	regulation of response to DNA damage stimulus
ND449_03615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND449_03620	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND449_03660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND449_03665	COG1238	metal cluster binding
ND449_03670	COG2918	glutathione biosynthetic process
ND449_03675	COG1854	S-ribosylhomocysteine lyase activity
ND449_03680	COG4536	flavin adenine dinucleotide binding
ND449_03685	COG4137	Cytochrome C assembly protein
ND449_03690	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND449_03700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND449_03705	COG0336	Belongs to the RNA methyltransferase TrmD family
ND449_03710	COG0335	large ribosomal subunit rRNA binding
ND449_03715	COG3137	Salt-induced outer membrane protein
ND449_03720	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND449_03725	COG3279	Response regulator of the LytR AlgR family
ND449_03730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND449_03735	COG1605	Chorismate mutase
ND449_03735	COG0287	Prephenate dehydrogenase
ND449_03740	COG0077	Prephenate dehydratase
ND449_03740	COG1605	Chorismate mutase
ND449_03750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND449_03755	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND449_03760	COG0564	pseudouridine synthase activity
ND449_03765	COG1496	oxidoreductase activity
ND449_03770	COG0542	response to heat
ND449_03805	COG3021	interspecies interaction between organisms
ND449_03810	COG0741	lytic transglycosylase activity
ND449_03810	COG1388	LysM domain
ND449_03820	COG2226	methyltransferase
ND449_03830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND449_03840	COG1960	acyl-CoA dehydrogenase activity
ND449_03845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND449_03850	COG0121	glutamine amidotransferase
ND449_03855	COG3034	peptidoglycan biosynthetic process
ND449_03865	COG1805	sodium ion transport
ND449_03870	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND449_03875	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND449_03880	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND449_03890	COG1477	protein flavinylation
ND449_03895	COG2991	Protein conserved in bacteria
ND449_03905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND449_03910	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND449_03915	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND449_03920	COG1073	alpha beta
ND449_03935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND449_03970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND449_03990	COG4126	flavin adenine dinucleotide binding
ND449_04000	COG2974	May be involved in recombination
ND449_04005	COG1940	carbohydrate kinase activity
ND449_04010	COG0419	ATPase involved in DNA repair
ND449_04015	COG0420	3'-5' exonuclease activity
ND449_04020	COG0745	RESPONSE REGULATOR receiver
ND449_04025	COG5002	protein histidine kinase activity
ND449_04040	COG1113	amino acid transport
ND449_04045	COG0366	Alpha amylase catalytic
ND449_04050	COG0300	oxidoreductase activity
ND449_04055	COG0450	alkyl hydroperoxide reductase
ND449_04060	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND449_04075	COG1862	Preprotein translocase
ND449_04080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND449_04085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND449_04090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND449_04095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND449_04095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND449_04100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND449_04110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND449_04115	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND449_04120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND449_04125	COG0142	geranyltranstransferase activity
ND449_04160	COG0693	protein deglycase activity
ND449_04165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND449_04170	COG1666	GTP binding
ND449_04175	COG2814	Major facilitator Superfamily
ND449_04185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND449_04190	COG1845	cytochrome c oxidase, subunit III
ND449_04195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND449_04200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND449_04210	COG2223	nitrite transmembrane transporter activity
ND449_04215	COG3056	Lipoprotein
ND449_04220	COG0271	Belongs to the BolA IbaG family
ND449_04230	COG0740	serine-type endopeptidase activity
ND449_04235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND449_04240	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND449_04245	COG0776	regulation of translation
ND449_04250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND449_04255	COG1555	photosystem II stabilization
ND449_04260	COG0824	Thioesterase
ND449_04265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND449_04270	COG4533	DNA binding
ND449_04285	COG1522	sequence-specific DNA binding
ND449_04290	COG1132	(ABC) transporter
ND449_04295	COG1132	(ABC) transporter
ND449_04300	COG0347	Belongs to the P(II) protein family
ND449_04305	COG0004	ammonium transporteR
ND449_04310	COG1946	Acyl-CoA thioesterase
ND449_04315	COG3695	enzyme binding
ND449_04340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND449_04345	COG0254	rRNA binding
ND449_04350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND449_04355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND449_04360	COG1309	transcriptional regulator
ND449_04365	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND449_04370	COG1196	nuclear chromosome segregation
ND449_04370	COG3264	Mechanosensitive ion channel
ND449_04385	COG2832	Protein of unknown function (DUF454)
ND449_04390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND449_04430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND449_04435	COG0326	Molecular chaperone. Has ATPase activity
ND449_04450	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND449_04455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND449_04460	COG4651	solute:proton antiporter activity
ND449_04460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND449_04465	COG0737	Belongs to the 5'-nucleotidase family
ND449_04470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND449_04475	COG3735	TraB family
ND449_04480	COG2217	Heavy metal translocating P-type atpase
ND449_04485	COG0789	Transcriptional regulator
ND449_04490	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND449_04495	COG0330	HflC and HflK could
ND449_04500	COG3118	belongs to the thioredoxin family
ND449_04505	COG0300	oxidoreductase activity
ND449_04510	COG2755	lipolytic protein G-D-S-L family
ND449_04515	COG4181	ATPase activity
ND449_04520	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND449_04525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND449_04530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND449_04535	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND449_04540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND449_04565	COG3188	usher protein
ND449_04570	COG3121	Chaperone
ND449_04600	COG2501	S4 domain
ND449_04605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND449_04620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND449_04625	COG1393	Belongs to the ArsC family
ND449_04635	COG1022	Amp-dependent synthetase and ligase
ND449_04660	COG3038	cytochrome b561
ND449_04690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND449_04700	COG1215	transferase activity, transferring glycosyl groups
ND449_04720	COG3250	beta-galactosidase activity
ND449_04735	COG1309	transcriptional regulator
ND449_04765	COG2197	response regulator
ND449_04770	COG1278	Cold shock
ND449_04790	COG3706	GGDEF domain
ND449_04800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND449_04810	COG2921	Belongs to the UPF0250 family
ND449_04815	COG1686	Belongs to the peptidase S11 family
ND449_04820	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND449_04825	COG0772	Belongs to the SEDS family
ND449_04830	COG0768	penicillin binding
ND449_04835	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND449_04840	COG0799	negative regulation of ribosome biogenesis
ND449_04845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND449_04850	COG1466	dna polymerase III delta subunit
ND449_04855	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND449_04865	COG2888	peptidyl-tyrosine sulfation
ND449_04870	COG1126	abc transporter atp-binding protein
ND449_04875	COG0765	amino acid transport
ND449_04880	COG0765	amino acid transport
ND449_04890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND449_04895	COG4535	Mg2 and Co2 transporter CorC
ND449_04900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND449_04905	COG1702	phosphate starvation-inducible protein PhoH
ND449_04910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND449_04915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND449_04950	COG0367	asparagine synthase
ND449_04955	COG0647	UMP catabolic process
ND449_04960	COG1940	carbohydrate kinase activity
ND449_04960	COG1846	Transcriptional regulator
ND449_04965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND449_04975	COG2190	(PTS) system
ND449_04975	COG1263	PTS System
ND449_04975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND449_05000	COG0735	belongs to the Fur family
ND449_05010	COG0840	transmembrane signaling receptor activity
ND449_05020	COG0596	Alpha beta hydrolase
ND449_05025	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND449_05030	COG0033	Phosphoglucomutase
ND449_05040	COG0745	RESPONSE REGULATOR receiver
ND449_05045	COG2205	protein histidine kinase activity
ND449_05050	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND449_05055	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND449_05075	COG3272	Protein of unknown function (DUF1722)
ND449_05080	COG0415	Belongs to the DNA photolyase family
ND449_05085	COG5212	phosphodiesterase
ND449_05090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND449_05095	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND449_05100	COG1984	allophanate hydrolase subunit 2
ND449_05105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND449_05140	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND449_05145	COG1053	succinate dehydrogenase
ND449_05150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND449_05155	COG0567	Dehydrogenase, E1 component
ND449_05160	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND449_05165	COG0045	succinate-CoA ligase (ADP-forming) activity
ND449_05170	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND449_05175	COG0737	Belongs to the 5'-nucleotidase family
ND449_05180	COG1271	oxidase subunit
ND449_05185	COG1294	oxidase, subunit
ND449_05190	COG4890	Cyd operon protein YbgT
ND449_05195	COG3790	cyd operon protein YbgE
ND449_05200	COG0824	Thioesterase
ND449_05205	COG0811	peptide transport
ND449_05210	COG0848	biopolymer transport protein
ND449_05215	COG3064	Membrane
ND449_05215	COG3064	Membrane
ND449_05220	COG0823	Involved in the tonB-independent uptake of proteins
ND449_05225	COG2885	chlorophyll binding
ND449_05230	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND449_05265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND449_05275	COG2205	protein histidine kinase activity
ND449_05275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND449_05285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND449_05290	COG0588	phosphoglycerate mutase activity
ND449_05300	COG2017	converts alpha-aldose to the beta-anomer
ND449_05310	COG1085	galactose-1-phosphate uridylyltransferase
ND449_05315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND449_05330	COG2005	Transcriptional regulator
ND449_05330	COG3585	molybdate ion transport
ND449_05340	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND449_05345	COG4149	molybdate abc transporter
ND449_05355	COG0561	phosphatase activity
ND449_05360	COG2706	6-phosphogluconolactonase activity
ND449_05375	COG0156	8-amino-7-oxononanoate synthase activity
ND449_05380	COG2226	methyltransferase
ND449_05395	COG0556	nucleotide-excision repair
ND449_05400	COG4628	conserved protein (DUF2132)
ND449_05415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND449_05420	COG1120	ATPase activity
ND449_05425	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND449_05430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND449_05440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND449_05445	COG0314	molybdopterin synthase activity
ND449_05450	COG0670	Belongs to the BI1 family
ND449_05455	COG0842	Transport permease protein
ND449_05460	COG0842	Transport permease protein
ND449_05465	COG1131	(ABC) transporter
ND449_05470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND449_05475	COG1309	transcriptional regulator
ND449_05480	COG0513	Belongs to the DEAD box helicase family
ND449_05485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND449_05495	COG1686	Belongs to the peptidase S11 family
ND449_05500	COG0277	FAD linked oxidase domain protein
ND449_05520	COG2261	transglycosylase associated protein
ND449_05530	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND449_05540	COG3639	organic phosphonate transmembrane transporter activity
ND449_05545	COG4807	Protein conserved in bacteria
ND449_05550	COG2897	thiosulfate sulfurtransferase activity
ND449_05555	COG1732	Glycine betaine
ND449_05560	COG1174	glycine betaine transport
ND449_05565	COG1125	glycine betaine transport
ND449_05570	COG1174	glycine betaine transport
ND449_05575	COG0531	amino acid
ND449_05580	COG1982	Orn Lys Arg decarboxylase major
ND449_05590	COG0697	spore germination
ND449_05605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND449_05610	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND449_05615	COG1126	abc transporter atp-binding protein
ND449_05620	COG0765	amino acid transport
ND449_05625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND449_05645	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND449_05650	COG2239	Acts as a magnesium transporter
ND449_05655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND449_05660	COG0488	(ABC) transporter
ND449_05665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND449_05670	COG0303	'Molybdopterin
ND449_05690	COG0583	DNA-binding transcription factor activity
ND449_05695	COG0477	Major facilitator Superfamily
ND449_05700	COG0302	gtp cyclohydrolase
ND449_05705	COG2311	Membrane
ND449_05730	COG2949	membrane
ND449_05735	COG0281	malic enzyme
ND449_05745	COG0583	DNA-binding transcription factor activity
ND449_05755	COG1346	cytolysis
ND449_05760	COG1380	Effector of murein hydrolase LrgA
ND449_05770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND449_05770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND449_05775	COG0489	protein tyrosine kinase activity
ND449_05780	COG0572	uridine kinase
ND449_05785	COG0717	Belongs to the dCTP deaminase family
ND449_05790	COG2982	Protein involved in outer membrane biogenesis
ND449_05795	COG3069	C4-dicarboxylate transmembrane transporter activity
ND449_05800	COG1253	flavin adenine dinucleotide binding
ND449_05805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND449_05810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND449_05815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND449_05825	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND449_05825	COG0140	phosphoribosyl-ATP diphosphatase activity
ND449_05835	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND449_05845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND449_05845	COG0131	Imidazoleglycerol-phosphate dehydratase
ND449_05850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND449_05855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND449_05870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND449_05875	COG0625	glutathione transferase activity
ND449_05890	COG0626	cystathionine gamma-synthase activity
ND449_05900	COG1686	Belongs to the peptidase S11 family
ND449_05905	COG1760	l-serine dehydratase
ND449_05910	COG0814	amino acid
ND449_05915	COG1349	DNA-binding transcription factor activity
ND449_05925	COG0671	phosphoesterase, PA-phosphatase related
ND449_05935	COG0569	domain protein
ND449_05935	COG2985	domain, Protein
ND449_05955	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND449_05960	COG3842	ATPase activity
ND449_05965	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND449_05970	COG1177	transmembrane transport
ND449_05985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND449_05990	COG4160	amino acid transport
ND449_05995	COG4215	(ABC) transporter
ND449_06000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND449_06005	COG1126	abc transporter atp-binding protein
ND449_06015	COG0393	Putative heavy-metal-binding
ND449_06020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND449_06025	COG0702	epimerase
ND449_06030	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND449_06035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND449_06040	COG1151	hydroxylamine reductase activity
ND449_06045	COG2431	L-lysine efflux transmembrane transporter activity
ND449_06050	COG3593	DNA synthesis involved in DNA repair
ND449_06055	COG2990	Protein conserved in bacteria
ND449_06060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND449_06070	COG1278	Cold shock
ND449_06075	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND449_06080	COG0542	response to heat
ND449_06085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND449_06095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND449_06105	COG0492	ferredoxin-NADP+ reductase activity
ND449_06110	COG1522	sequence-specific DNA binding
ND449_06115	COG1674	ftsk spoiiie
ND449_06115	COG3107	peptidoglycan biosynthetic process
ND449_06120	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND449_06125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND449_06130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND449_06135	COG2814	Major facilitator Superfamily
ND449_06140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND449_06145	COG1882	Formate acetyltransferase
ND449_06150	COG2116	formate transmembrane transporter activity
ND449_06155	COG1944	ATP diphosphatase activity
ND449_06160	COG0252	asparaginase activity
ND449_06170	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND449_06180	COG0539	negative regulation of cytoplasmic translation
ND449_06190	COG2333	competence protein COMEC
ND449_06190	COG0658	competence protein
ND449_06200	COG1663	tetraacyldisaccharide 4'-kinase activity
ND449_06205	COG5383	Protein conserved in bacteria
ND449_06215	COG1278	Cold shock
ND449_06220	COG2835	tetraacyldisaccharide 4'-kinase activity
ND449_06225	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND449_06230	COG3173	Aminoglycoside phosphotransferase
ND449_06235	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND449_06240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND449_06245	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND449_06255	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND449_06260	COG2989	Protein conserved in bacteria
ND449_06265	COG3108	Peptidase M15
ND449_06270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND449_06275	COG1448	Aminotransferase
ND449_06290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND449_06295	COG0308	aminopeptidase N
ND449_06300	COG0167	dihydroorotate dehydrogenase activity
ND449_06310	COG0633	Ferredoxin
ND449_06310	COG3217	Mosc domain protein beta barrel domain protein
ND449_06315	COG0116	Belongs to the methyltransferase superfamily
ND449_06315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND449_06320	COG0488	(ABC) transporter
ND449_06325	COG2995	paraquat-inducible protein a
ND449_06330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND449_06330	COG3008	intermembrane lipid transfer
ND449_06335	COG3009	Protein conserved in bacteria
ND449_06340	COG3130	regulation of translation
ND449_06345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND449_06350	COG1067	ATP-dependent peptidase activity
ND449_06355	COG3120	sequence-specific DNA binding
ND449_06365	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND449_06370	COG3070	regulator of competence-specific genes
ND449_06375	COG1289	transmembrane transporter activity
ND449_06380	COG3304	Inner membrane component domain
ND449_06385	COG0210	DNA helicase
ND449_06390	COG1803	Methylglyoxal synthase
ND449_06400	COG1832	CoA-binding protein
ND449_06405	COG3785	DNA binding
ND449_06410	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND449_06415	COG1254	Belongs to the acylphosphatase family
ND449_06420	COG2920	part of a sulfur-relay system
ND449_06430	COG0288	reversible hydration of carbon dioxide
ND449_06450	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND449_06455	COG2943	transferase activity, transferring hexosyl groups
ND449_06470	COG0675	Transposase, IS605 OrfB family
ND449_06485	COG1560	Kdo2-lipid A biosynthetic process
ND449_06495	COG0628	permease
ND449_06520	COG0418	dihydroorotase activity
ND449_06525	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND449_06535	COG1530	ribonuclease E activity
ND449_06540	COG0564	pseudouridine synthase activity
ND449_06545	COG0424	maF-like protein
ND449_06550	COG1399	metal-binding, possibly nucleic acid-binding protein
ND449_06555	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND449_06565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND449_06570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND449_06580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND449_06585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND449_06590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND449_06595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND449_06600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND449_06605	COG0470	DNA polymerase III
ND449_06610	COG0084	hydrolase, TatD family'
ND449_06615	COG1263	PTS System
ND449_06615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND449_06620	COG0537	adenosine 5'-monophosphoramidase activity
ND449_06625	COG5633	Lipoprotein
ND449_06630	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND449_06645	COG3150	esterase
ND449_06650	COG1252	NADH dehydrogenase
ND449_06655	COG3134	Outer membrane lipoprotein
ND449_06660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND449_06665	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND449_06675	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND449_06695	COG2850	peptidyl-arginine hydroxylation
ND449_06700	COG2205	protein histidine kinase activity
ND449_06705	COG0745	RESPONSE REGULATOR receiver
ND449_06715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND449_06720	COG2915	High frequency lysogenization protein hflD homolog
ND449_06725	COG0482	sulfurtransferase activity
ND449_06735	COG1187	pseudouridine synthase activity
ND449_06740	COG0538	isocitrate dehydrogenase activity
ND449_06745	COG2771	luxR family
ND449_06750	COG3916	Acyl-homoserine-lactone synthase
ND449_06755	COG2723	6-phospho-beta-galactosidase activity
ND449_06765	COG0339	signal peptide processing
ND449_06770	COG0840	transmembrane signaling receptor activity
ND449_06795	COG0675	Transposase, IS605 OrfB family
ND449_06805	COG4565	transcriptional regulatory protein
ND449_06810	COG3290	protein histidine kinase activity
ND449_06815	COG0471	metal ion transport
ND449_06855	COG4977	sequence-specific DNA binding
ND449_06860	COG1702	phosphate starvation-inducible protein PhoH
ND449_06865	COG0387	Pfam Sodium calcium exchanger
ND449_06870	COG2375	cellular response to nickel ion
ND449_06875	COG3850	Histidine kinase
ND449_06885	COG1294	oxidase, subunit
ND449_06890	COG1271	oxidase subunit
ND449_06895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND449_06900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND449_06905	COG3138	arginine N-succinyltransferase
ND449_06915	COG3724	N-succinylarginine dihydrolase activity
ND449_06935	COG1228	amidohydrolase
ND449_06945	COG0402	S-adenosylhomocysteine deaminase activity
ND449_06965	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND449_06970	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND449_06975	COG3383	formate dehydrogenase (NAD+) activity
ND449_06980	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND449_06985	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND449_06995	COG3260	NADH ubiquinone oxidoreductase 20
ND449_07000	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND449_07005	COG3261	NADH dehydrogenase
ND449_07005	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND449_07010	COG0650	Formate hydrogenlyase subunit 4
ND449_07015	COG0651	ATP synthesis coupled electron transport
ND449_07020	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND449_07030	COG0375	protein maturation
ND449_07035	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND449_07040	COG0298	carbon dioxide binding
ND449_07045	COG0409	Hydrogenase expression formation protein
ND449_07050	COG0309	Hydrogenase expression formation protein (HypE)
ND449_07085	COG2207	Transcriptional regulator
ND449_07085	COG3708	Transcriptional regulator
ND449_07090	COG0012	GTP binding
ND449_07100	COG0193	aminoacyl-tRNA hydrolase activity
ND449_07110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND449_07120	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND449_07125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND449_07130	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND449_07135	COG2890	protein-(glutamine-N5) methyltransferase activity
ND449_07150	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND449_07155	COG0659	secondary active sulfate transmembrane transporter activity
ND449_07160	COG3706	GGDEF domain
ND449_07185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND449_07195	COG3381	protein complex oligomerization
ND449_07215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND449_07225	COG0673	inositol 2-dehydrogenase activity
ND449_07230	COG0728	peptidoglycan biosynthetic process
ND449_07255	COG3102	Protein conserved in bacteria
ND449_07260	COG3142	Participates in the control of copper homeostasis
ND449_07275	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND449_07280	COG1801	Protein of unknown function DUF72
ND449_07290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND449_07295	COG0494	nUDIX hydrolase
ND449_07305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND449_07315	COG2255	four-way junction helicase activity
ND449_07320	COG3104	oligopeptide transport
ND449_07325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND449_07330	COG1121	(ABC) transporter
ND449_07335	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND449_07340	COG0739	heme binding
ND449_07345	COG1560	Kdo2-lipid A biosynthetic process
ND449_07350	COG0469	pyruvate kinase activity
ND449_07355	COG1737	Transcriptional regulator
ND449_07360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND449_07365	COG0800	Aldolase
ND449_07375	COG2076	Multidrug Resistance protein
ND449_07380	COG0251	oxidation-reduction process
ND449_07385	COG1199	ATP-dependent helicase activity
ND449_07390	COG1214	PFAM Peptidase M22, glycoprotease
ND449_07395	COG3065	identical protein binding
ND449_07400	COG0318	PFAM AMP-dependent synthetase and ligase
ND449_07405	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND449_07410	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND449_07415	COG2894	cell division
ND449_07420	COG0850	regulation of cytokinetic process
ND449_07425	COG3100	YcgL domain-containing protein
ND449_07430	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND449_07435	COG2983	Belongs to the UPF0260 family
ND449_07455	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND449_07465	COG2719	SpoVR family
ND449_07470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND449_07475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND449_07480	COG2814	Major facilitator Superfamily
ND449_07490	COG2200	EAL domain
ND449_07490	COG2202	Pas domain
ND449_07490	COG2199	diguanylate cyclase activity
ND449_07510	COG2718	Belongs to the UPF0229 family
ND449_07515	COG2766	serine protein kinase
ND449_07525	COG3713	MltA-interacting MipA family protein
ND449_07530	COG2194	sulfuric ester hydrolase activity
ND449_07545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND449_07550	COG3139	Protein of unknown function (DUF1315)
ND449_07555	COG1335	isochorismatase
ND449_07560	COG0252	asparaginase activity
ND449_07565	COG0616	signal peptide processing
ND449_07570	COG0778	Nitroreductase
ND449_07580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND449_07590	COG0494	nUDIX hydrolase
ND449_07595	COG0708	Exodeoxyribonuclease III
ND449_07625	COG0788	formyltetrahydrofolate deformylase activity
ND449_07635	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND449_07640	COG0745	RESPONSE REGULATOR receiver
ND449_07660	COG1454	alcohol dehydrogenase
ND449_07660	COG1012	belongs to the aldehyde dehydrogenase family
ND449_07670	COG2095	MarC family integral membrane protein
ND449_07675	COG4166	transmembrane transport
ND449_07690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND449_07705	COG3099	Belongs to the UPF0263 family
ND449_07710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND449_07730	COG2350	Protein conserved in bacteria
ND449_07745	COG3710	Transcriptional regulator
ND449_07780	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND449_07805	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND449_07810	COG3047	cAMP biosynthetic process
ND449_07825	COG0133	tryptophan synthase activity
ND449_07830	COG0135	phosphoribosylanthranilate isomerase activity
ND449_07830	COG0134	indole-3-glycerol-phosphate synthase activity
ND449_07840	COG0512	Glutamine amidotransferase of anthranilate synthase
ND449_07850	COG0613	PHP domain protein
ND449_07855	COG0009	L-threonylcarbamoyladenylate synthase
ND449_07875	COG1187	pseudouridine synthase activity
ND449_07885	COG1028	Short-chain dehydrogenase reductase Sdr
ND449_07890	COG0616	signal peptide processing
ND449_07905	COG0583	DNA-binding transcription factor activity
ND449_07920	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND449_07930	COG0671	phosphoesterase, PA-phosphatase related
ND449_07935	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND449_07940	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND449_07960	COG0023	Translation Initiation Factor
ND449_07970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND449_07975	COG5002	protein histidine kinase activity
ND449_07975	COG3447	MASE1 domain protein
ND449_07975	COG5001	Diguanylate cyclase
ND449_07980	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND449_07985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND449_07995	COG4659	FMN binding
ND449_08005	COG3708	Transcriptional regulator
ND449_08005	COG2207	Transcriptional regulator
ND449_08020	COG4657	Part of a membrane complex involved in electron transport
ND449_08030	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND449_08040	COG0673	inositol 2-dehydrogenase activity
ND449_08045	COG0385	Bile acid
ND449_08050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND449_08055	COG5339	Protein conserved in bacteria
ND449_08060	COG1482	cell wall glycoprotein biosynthetic process
ND449_08065	COG0114	fumarate hydratase activity
ND449_08075	COG1940	carbohydrate kinase activity
ND449_08080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND449_08100	COG1742	UPF0060 membrane protein
ND449_08105	COG4221	oxidoreductase activity
ND449_08110	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND449_08130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND449_08170	COG1011	Hydrolase
ND449_08180	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND449_08185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND449_08190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND449_08195	COG0589	response to stress
ND449_08225	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND449_08230	COG3623	hexulose-6-phosphate isomerase
ND449_08235	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND449_08240	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND449_08250	COG0531	amino acid
ND449_08260	COG0745	RESPONSE REGULATOR receiver
ND449_08265	COG2205	protein histidine kinase activity
ND449_08280	COG2207	Transcriptional regulator
ND449_08285	COG1881	PFAM PEBP family protein
ND449_08295	COG3591	Belongs to the peptidase S1B family
ND449_08300	COG1643	Atp-dependent helicase
ND449_08305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND449_08310	COG3784	Protein of unknown function (DUF1318)
ND449_08325	COG2911	Protein conserved in bacteria
ND449_08330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND449_08335	COG3187	Heat shock protein
ND449_08340	COG3042	response to heat
ND449_08345	COG1285	pathogenesis
ND449_08355	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND449_08355	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND449_08355	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND449_08355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND449_08370	COG4166	transmembrane transport
ND449_08375	COG2866	Carboxypeptidase
ND449_08380	COG4948	Mandelate Racemase Muconate Lactonizing
ND449_08385	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND449_08395	COG5642	Protein of unknown function (DUF2384)
ND449_08400	COG5654	RES domain protein
ND449_08405	COG3768	UPF0283 membrane protein
ND449_08410	COG3106	COG3106 Predicted ATPase
ND449_08420	COG1983	PspC domain protein
ND449_08430	COG1842	Phage shock protein A
ND449_08435	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND449_08450	COG4166	transmembrane transport
ND449_08460	COG4171	peptide transport system, permease
ND449_08465	COG4172	Belongs to the ABC transporter superfamily
ND449_08470	COG4172	Belongs to the ABC transporter superfamily
ND449_08480	COG3104	oligopeptide transport
ND449_08490	COG0484	heat shock protein binding
ND449_08535	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND449_08540	COG3133	Outer membrane lipoprotein
ND449_08545	COG1846	Transcriptional regulator
ND449_08555	COG4989	oxidoreductase activity
ND449_08560	COG3313	Fe-S protein
ND449_08565	COG2194	sulfuric ester hydrolase activity
ND449_08570	COG1309	transcriptional regulator
ND449_08575	COG1902	pentaerythritol trinitrate reductase activity
ND449_08590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND449_08595	COG0791	NLP P60 protein
ND449_08600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND449_08610	COG1609	Transcriptional regulator
ND449_08615	COG0583	DNA-binding transcription factor activity
ND449_08620	COG2814	Major facilitator Superfamily
ND449_08625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND449_08630	COG0307	riboflavin synthase, alpha
ND449_08665	COG1376	ErfK ybiS ycfS ynhG family protein
ND449_08665	COG1388	LysM domain
ND449_08670	COG2166	iron-sulfur cluster assembly
ND449_08680	COG0719	Fe-S assembly protein
ND449_08685	COG0396	ATPase activity
ND449_08690	COG0719	Fe-S assembly protein
ND449_08695	COG0316	Belongs to the HesB IscA family
ND449_08700	COG2050	protein possibly involved in aromatic compounds catabolism
ND449_08705	COG0277	FAD linked oxidase domain protein
ND449_08705	COG0247	lactate metabolic process
ND449_08710	COG0628	permease
ND449_08720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND449_08720	COG0574	Belongs to the PEP-utilizing enzyme family
ND449_08725	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND449_08730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND449_08740	COG4771	TonB-dependent receptor
ND449_08745	COG3720	iron ion transport
ND449_08750	COG4558	Periplasmic binding protein
ND449_08755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND449_08760	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND449_08770	COG0095	Lipoate-protein ligase
ND449_08775	COG0791	NLP P60 protein
ND449_08780	COG2076	Multidrug Resistance protein
ND449_08785	COG2076	Multidrug Resistance protein
ND449_08790	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND449_08805	COG0463	Glycosyl transferase, family 2
ND449_08810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND449_08820	COG4139	cobalamin transport
ND449_08865	COG2184	nucleotidyltransferase activity
ND449_08880	COG2314	TM2 domain
ND449_08885	COG0776	regulation of translation
ND449_08955	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND449_08960	COG1121	(ABC) transporter
ND449_08965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND449_08970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND449_08975	COG3001	Fructosamine kinase
ND449_08985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND449_08990	COG1988	membrane-bound metal-dependent
ND449_08995	COG1823	symporter activity
ND449_09000	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND449_09010	COG2814	Major facilitator Superfamily
ND449_09020	COG0501	Belongs to the peptidase M48B family
ND449_09025	COG0793	Belongs to the peptidase S41A family
ND449_09035	COG1956	GAF domain-containing protein
ND449_09040	COG2995	paraquat-inducible protein a
ND449_09045	COG3008	intermembrane lipid transfer
ND449_09050	COG3706	GGDEF domain
ND449_09050	COG2203	Gaf domain
ND449_09050	COG4251	negative regulation of phosphorylation
ND449_09050	COG5001	Diguanylate cyclase
ND449_09260	COG3772	lysozyme
ND449_09310	COG1674	ftsk spoiiie
ND449_09310	COG1178	ABC-type Fe3 transport system permease component
ND449_09430	COG1276	copper resistance
ND449_09435	COG2372	response to copper ion
ND449_09440	COG1528	Iron-storage protein
ND449_09460	COG1770	oligopeptidase
ND449_09470	COG3097	Belongs to the UPF0267 family
ND449_09475	COG3141	response to X-ray
ND449_09480	COG0513	Belongs to the DEAD box helicase family
ND449_09500	COG0494	nUDIX hydrolase
ND449_09505	COG1760	l-serine dehydratase
ND449_09510	COG1253	flavin adenine dinucleotide binding
ND449_09515	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND449_09515	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND449_09520	COG3715	PTS system
ND449_09525	COG3716	PTS system mannose fructose sorbose family IID component
ND449_09530	COG4811	Protein of unknown function (DUF986)
ND449_09535	COG1971	Probably functions as a manganese efflux pump
ND449_09555	COG1960	acyl-CoA dehydrogenase activity
ND449_09565	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND449_09595	COG2226	methyltransferase
ND449_09600	COG0768	penicillin binding
ND449_09605	COG1496	oxidoreductase activity
ND449_09625	COG1113	amino acid transport
ND449_09660	COG2207	Transcriptional regulator
ND449_09680	COG1132	(ABC) transporter
ND449_09690	COG2203	Gaf domain
ND449_09690	COG3706	GGDEF domain
ND449_09690	COG5001	Diguanylate cyclase
ND449_09690	COG4251	negative regulation of phosphorylation
ND449_09710	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND449_09730	COG1278	Cold shock
ND449_09735	COG1278	Cold shock
ND449_09740	COG1278	Cold shock
ND449_09755	COG1917	Cupin 2, conserved barrel domain protein
ND449_09755	COG2169	Transcriptional regulator
ND449_09760	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND449_09765	COG2723	6-phospho-beta-galactosidase activity
ND449_09770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND449_09775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND449_09780	COG1187	pseudouridine synthase activity
ND449_09790	COG3122	Protein conserved in bacteria
ND449_09795	COG1757	Na H antiporter
ND449_09810	COG2235	arginine
ND449_09825	COG0076	glutamate decarboxylase activity
ND449_09830	COG0531	amino acid
ND449_09865	COG2153	protein acetylation
ND449_09870	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND449_09900	COG0840	transmembrane signaling receptor activity
ND449_09905	COG2801	Transposase and inactivated derivatives
ND449_09925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND449_09930	COG0322	excinuclease ABC activity
ND449_09935	COG2197	response regulator
ND449_09960	COG1113	amino acid transport
ND449_09970	COG0531	amino acid
ND449_09975	COG3710	Transcriptional regulator
ND449_09980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND449_09985	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND449_09985	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND449_09985	COG0506	proline dehydrogenase activity
ND449_09990	COG1126	abc transporter atp-binding protein
ND449_09995	COG0765	amino acid transport
ND449_10000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND449_10005	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND449_10015	COG1191	sigma factor activity
ND449_10055	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND449_10060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND449_10075	COG1677	Flagellar hook-basal body complex protein FliE
ND449_10085	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND449_10090	COG1317	bacterial-type flagellum organization
ND449_10095	COG1157	protein secretion by the type III secretion system
ND449_10110	COG1580	Controls the rotational direction of flagella during chemotaxis
ND449_10190	COG1558	bacterial-type flagellum-dependent cell motility
ND449_10195	COG1815	bacterial-type flagellum-dependent cell motility
ND449_10205	COG2747	anti-sigma28 factor FlgM
ND449_10210	COG3418	PFAM FlgN family protein
ND449_10220	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND449_10225	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND449_10230	COG4935	Belongs to the peptidase S8 family
ND449_10230	COG1404	Belongs to the peptidase S8 family
ND449_10235	COG2197	response regulator
ND449_10250	COG3188	usher protein
ND449_10255	COG3121	Chaperone
ND449_10265	COG3539	Fimbrial protein
ND449_10295	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND449_10300	COG0745	RESPONSE REGULATOR receiver
ND449_10310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND449_10315	COG0840	transmembrane signaling receptor activity
ND449_10320	COG0840	transmembrane signaling receptor activity
ND449_10325	COG0835	chemotaxis
ND449_10330	COG2198	Histidine kinase
ND449_10330	COG0643	Histidine kinase
ND449_10335	COG1360	Flagellar Motor Protein
ND449_10355	COG0589	response to stress
ND449_10360	COG1285	pathogenesis
ND449_10365	COG0840	transmembrane signaling receptor activity
ND449_10385	COG1609	Transcriptional regulator
ND449_10395	COG0604	alcohol dehydrogenase
ND449_10395	COG1028	Short-chain dehydrogenase reductase Sdr
ND449_10395	COG3321	synthase
ND449_10430	COG0582	viral genome integration into host DNA
ND449_10445	COG3423	Transcriptional regulator
ND449_10480	COG3451	type IV secretory pathway VirB4
ND449_10500	COG3736	Type IV secretory pathway, component VirB8
ND449_10515	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ND449_10530	COG4227	nucleotidyltransferase activity
ND449_10595	COG0471	metal ion transport
ND449_10610	COG3051	citrate lyase alpha subunit
ND449_10615	COG2301	Belongs to the HpcH HpaI aldolase family
ND449_10620	COG3052	prosthetic group binding
ND449_10625	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND449_10630	COG3290	protein histidine kinase activity
ND449_10635	COG4565	transcriptional regulatory protein
ND449_10650	COG2271	Major facilitator Superfamily
ND449_10655	COG1840	ABC-type Fe3 transport system, periplasmic component
ND449_10665	COG3842	ATPase activity
ND449_10685	COG1289	transmembrane transporter activity
ND449_10695	COG2925	Exonuclease
ND449_10700	COG0531	amino acid
ND449_10705	COG4771	TonB-dependent receptor
ND449_10715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND449_10725	COG0833	amino acid
ND449_10730	COG0583	DNA-binding transcription factor activity
ND449_10740	COG2855	membrane
ND449_10745	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND449_10750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND449_10750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND449_10750	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND449_10755	COG1105	Belongs to the carbohydrate kinase PfkB family
ND449_10770	COG3005	denitrification pathway
ND449_10775	COG0243	molybdopterin cofactor binding
ND449_10790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND449_10800	COG0246	Mannitol dehydrogenase
ND449_10810	COG0523	cobalamin synthesis protein
ND449_10815	COG0671	phosphoesterase, PA-phosphatase related
ND449_10820	COG0791	NLP P60 protein
ND449_10825	COG2200	EAL domain
ND449_10830	COG4166	transmembrane transport
ND449_10835	COG4174	ABC transporter (Permease)
ND449_10840	COG4239	(ABC) transporter, permease
ND449_10845	COG4172	Belongs to the ABC transporter superfamily
ND449_10855	COG2814	Major facilitator Superfamily
ND449_10860	COG1187	pseudouridine synthase activity
ND449_10865	COG1061	Type III restriction enzyme res subunit
ND449_10880	COG3082	Protein of unknown function (DUF1414)
ND449_10885	COG3083	sulfuric ester hydrolase activity
ND449_10910	COG3778	Protein conserved in bacteria
ND449_10915	COG3299	homolog of phage Mu protein gp47
ND449_10960	COG4386	tail sheath protein
ND449_11010	COG4626	Terminase
ND449_11010	COG1802	Transcriptional regulator
ND449_11035	COG1876	peptidase activity
ND449_11065	COG2815	serine threonine protein kinase
ND449_11065	COG0515	serine threonine protein kinase
ND449_11080	COG1403	HNH endonuclease
ND449_11095	COG4725	Belongs to the MT-A70-like family
ND449_11100	COG4626	Terminase
ND449_11100	COG1802	Transcriptional regulator
ND449_11135	COG5532	Uncharacterized conserved protein (DUF2303)
ND449_11140	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND449_11190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND449_11195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND449_11215	COG2223	nitrite transmembrane transporter activity
ND449_11220	COG0642	Histidine kinase
ND449_11220	COG2198	Histidine kinase
ND449_11230	COG2205	protein histidine kinase activity
ND449_11230	COG0784	Response regulator, receiver
ND449_11240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND449_11245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND449_11255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND449_11265	COG4574	serine-type endopeptidase inhibitor activity
ND449_11275	COG2246	polysaccharide biosynthetic process
ND449_11290	COG0814	amino acid
ND449_11315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND449_11320	COG0596	Alpha beta hydrolase
ND449_11325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND449_11330	COG1169	isochorismate synthase
ND449_11335	COG4575	ribosome binding
ND449_11350	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND449_11355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND449_11365	COG0839	Belongs to the complex I subunit 6 family
ND449_11370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND449_11375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND449_11380	COG1034	ATP synthesis coupled electron transport
ND449_11400	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND449_11405	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND449_11410	COG0583	DNA-binding transcription factor activity
ND449_11415	COG0436	Aminotransferase
ND449_11420	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND449_11425	COG0490	domain, Protein
ND449_11425	COG0471	metal ion transport
ND449_11435	COG3013	Belongs to the UPF0304 family
ND449_11440	COG3092	negative regulation of chromosome organization
ND449_11450	COG0857	belongs to the CobB CobQ family
ND449_11450	COG0280	phosphate acetyltransferase
ND449_11455	COG1609	Transcriptional regulator
ND449_11470	COG3037	sugar-specific permease SgaT UlaA
ND449_11475	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND449_11480	COG0622	Phosphoesterase
ND449_11495	COG0625	glutathione transferase activity
ND449_11500	COG1090	epimerase
ND449_11510	COG4160	amino acid transport
ND449_11515	COG4215	(ABC) transporter
ND449_11530	COG0163	prenyltransferase activity
ND449_11535	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND449_11540	COG1286	toxin biosynthetic process
ND449_11545	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND449_11550	COG0285	dihydrofolate synthase activity
ND449_11560	COG0586	Pfam SNARE associated Golgi protein
ND449_11570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND449_11595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND449_11600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND449_11630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND449_11645	COG3101	peptidyl-lysine hydroxylation
ND449_11650	COG0730	response to heat
ND449_11655	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND449_11665	COG2890	protein-(glutamine-N5) methyltransferase activity
ND449_11670	COG2840	Smr protein MutS2
ND449_11675	COG2062	phosphohistidine phosphatase, SixA
ND449_11680	COG1024	Enoyl-CoA hydratase
ND449_11680	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND449_11685	COG0183	Belongs to the thiolase family
ND449_11690	COG3691	Protein conserved in bacteria
ND449_11705	COG4235	cytochrome complex assembly
ND449_11705	COG3088	subunit of a heme lyase
ND449_11710	COG3088	subunit of a heme lyase
ND449_11710	COG4235	cytochrome complex assembly
ND449_11715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND449_11720	COG1138	Cytochrome C-type biogenesis protein
ND449_11725	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND449_11730	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND449_11735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND449_11740	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND449_11755	COG0582	viral genome integration into host DNA
ND449_11760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ND449_11815	COG2824	Alkylphosphonate utilization operon protein PhnA
ND449_11820	COG2951	lytic endotransglycosylase activity
ND449_11825	COG1598	PFAM Uncharacterised protein family UPF0150
ND449_11835	COG3038	cytochrome b561
ND449_11840	COG0436	Aminotransferase
ND449_11850	COG3275	phosphorelay sensor kinase activity
ND449_11855	COG3279	Response regulator of the LytR AlgR family
ND449_11860	COG2223	nitrite transmembrane transporter activity
ND449_11865	COG0837	glucose binding
ND449_11885	COG1914	H( )-stimulated, divalent metal cation uptake system
ND449_11890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND449_11960	COG3530	Putative quorum-sensing-regulated virulence factor
ND449_11965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND449_11975	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND449_11985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND449_12000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND449_12010	COG4208	sulfate ABC transporter
ND449_12015	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND449_12020	COG4150	thiosulfate binding
ND449_12030	COG1737	Transcriptional regulator
ND449_12035	COG2731	YhcH YjgK YiaL family protein
ND449_12050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND449_12055	COG2837	iron assimilation
ND449_12065	COG3111	PFAM Bacterial OB fold (BOF) protein
ND449_12125	COG1671	Belongs to the UPF0178 family
ND449_12130	COG0280	phosphate acetyltransferase
ND449_12130	COG0281	malic enzyme
ND449_12135	COG0494	nUDIX hydrolase
ND449_12140	COG3005	denitrification pathway
ND449_12145	COG3043	anaerobic respiration
ND449_12150	COG0243	molybdopterin cofactor binding
ND449_12155	COG3062	negative regulation of establishment of protein localization
ND449_12160	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND449_12160	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND449_12165	COG2197	response regulator
ND449_12175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND449_12185	COG1605	Chorismate mutase
ND449_12190	COG1393	Belongs to the ArsC family
ND449_12195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND449_12200	COG1876	peptidase activity
ND449_12210	COG0400	carboxylic ester hydrolase activity
ND449_12230	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND449_12235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND449_12240	COG2716	regulation of RNA biosynthetic process
ND449_12245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND449_12250	COG0628	permease
ND449_12255	COG4783	chaperone-mediated protein folding
ND449_12260	COG1393	Belongs to the ArsC family
ND449_12265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND449_12270	COG2233	PERMEase
ND449_12275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND449_12280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND449_12285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND449_12290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND449_12300	COG0581	inorganic phosphate transmembrane transporter activity
ND449_12305	COG0573	inorganic phosphate transmembrane transporter activity
ND449_12310	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND449_12325	COG2239	Acts as a magnesium transporter
ND449_12330	COG0443	Heat shock 70 kDa protein
ND449_12340	COG3121	Chaperone
ND449_12360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND449_12370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND449_12375	COG0477	Major facilitator Superfamily
ND449_12380	COG2205	protein histidine kinase activity
ND449_12385	COG0745	RESPONSE REGULATOR receiver
ND449_12390	COG3422	double-strand break repair
ND449_12395	COG0826	peptidase U32
ND449_12400	COG1597	lipid kinase activity
ND449_12415	COG0351	phosphomethylpyrimidine kinase
ND449_12430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND449_12430	COG0519	Catalyzes the synthesis of GMP from XMP
ND449_12435	COG0517	IMP dehydrogenase activity
ND449_12435	COG0516	GMP reductase activity
ND449_12440	COG1570	exodeoxyribonuclease VII activity
ND449_12445	COG1645	bacterial-type flagellum-dependent swarming motility
ND449_12455	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND449_12460	COG2976	Protein conserved in bacteria
ND449_12465	COG0124	histidyl-tRNA synthetase
ND449_12485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND449_12500	COG4953	penicillin-binding protein 1C
ND449_12505	COG2373	Large extracellular alpha-helical protein
ND449_12520	COG2975	iron-sulfur cluster assembly
ND449_12525	COG0633	Ferredoxin
ND449_12530	COG0443	Heat shock 70 kDa protein
ND449_12545	COG0822	iron-sulfur transferase activity
ND449_12555	COG1959	2 iron, 2 sulfur cluster binding
ND449_12560	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND449_12570	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND449_12575	COG3683	transport system, periplasmic component
ND449_12580	COG3711	transcriptional antiterminator
ND449_12585	COG2814	Major facilitator Superfamily
ND449_12595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND449_12595	COG1017	nitric oxide dioxygenase activity
ND449_12600	COG2188	Transcriptional regulator
ND449_12610	COG3457	Alanine racemase
ND449_12615	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND449_12630	COG0347	Belongs to the P(II) protein family
ND449_12635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND449_12635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND449_12640	COG2204	response regulator
ND449_12645	COG3170	Tfp pilus assembly protein FimV
ND449_12650	COG2205	protein histidine kinase activity
ND449_12665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND449_12675	COG0560	Phosphoserine phosphatase
ND449_12680	COG1263	PTS System
ND449_12680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND449_12690	COG1737	Transcriptional regulator
ND449_12695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND449_12705	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND449_12715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND449_12730	COG0481	GTPase activity
ND449_12735	COG3086	response to oxidative stress
ND449_12745	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND449_12755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND449_12765	COG0513	Belongs to the DEAD box helicase family
ND449_12780	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND449_12790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND449_12795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND449_12800	COG0497	DNA recombination
ND449_12805	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND449_12815	COG2867	negative regulation of translational initiation
ND449_12820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND449_12830	COG0582	viral genome integration into host DNA
ND449_12860	COG3596	GTP binding
ND449_12865	COG2378	regulation of single-species biofilm formation
ND449_12875	COG2378	regulation of single-species biofilm formation
ND449_12900	COG2003	Belongs to the UPF0758 family
ND449_12955	COG3121	Chaperone
ND449_12960	COG3188	usher protein
ND449_12985	COG0583	DNA-binding transcription factor activity
ND449_13060	COG1069	ribulokinase activity
ND449_13070	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND449_13075	COG1129	ABC transporter
ND449_13095	COG1620	l-lactate permease
ND449_13100	COG1304	FMN binding
ND449_13105	COG0579	oxidoreductase
ND449_13110	COG1278	Cold shock
ND449_13140	COG1780	Probably involved in ribonucleotide reductase function
ND449_13145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND449_13155	COG4175	Glycine betaine
ND449_13160	COG4176	ABC-type proline glycine betaine transport system permease component
ND449_13165	COG2113	Glycine betaine
ND449_13175	COG2814	Major facilitator Superfamily
ND449_13180	COG1846	Transcriptional regulator
ND449_13190	COG1566	PFAM secretion protein HlyD family protein
ND449_13195	COG2814	Major facilitator Superfamily
ND449_13200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND449_13205	COG3118	belongs to the thioredoxin family
ND449_13210	COG3148	PFAM DTW domain containing protein
ND449_13215	COG0045	succinate-CoA ligase (ADP-forming) activity
ND449_13215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND449_13215	COG1042	CoA-binding domain protein
ND449_13220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND449_13225	COG5544	Lipoprotein
ND449_13250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND449_13260	COG2011	ABC-type metal ion transport system permease component
ND449_13265	COG1464	Belongs to the NlpA lipoprotein family
ND449_13275	COG1720	tRNA m6t6A37 methyltransferase activity
ND449_13280	COG0442	prolyl-tRNA aminoacylation
ND449_13285	COG3015	lipoprotein NlpE involved in copper resistance
ND449_13295	COG4681	YaeQ
ND449_13305	COG4568	rho-dependent transcription termination
ND449_13320	COG0346	lactoylglutathione lyase activity
ND449_13335	COG0825	malonyl-CoA metabolic process
ND449_13340	COG0587	DNA-directed DNA polymerase activity
ND449_13345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND449_13365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND449_13370	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND449_13380	COG0750	zinc metalloprotease
ND449_13385	COG0575	Belongs to the CDS family
ND449_13405	COG0528	UMP kinase activity
ND449_13410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND449_13425	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND449_13430	COG2171	N-acyltransferase activity
ND449_13445	COG0564	pseudouridine synthase activity
ND449_13450	COG3098	single-species biofilm formation
ND449_13465	COG1611	Belongs to the LOG family
ND449_13475	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND449_13480	COG2363	Small membrane protein
ND449_13485	COG0583	DNA-binding transcription factor activity
ND449_13495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND449_13500	COG2166	iron-sulfur cluster assembly
ND449_13505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND449_13510	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND449_13530	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND449_13535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND449_13535	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND449_13540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND449_13545	COG1074	ATP-dependent DNA helicase activity
ND449_13550	COG1025	Belongs to the peptidase M16 family
ND449_13555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND449_13560	COG4967	type IV pilus modification protein PilV
ND449_13585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND449_13590	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND449_13600	COG3066	DNA modification
ND449_13605	COG0861	Integral membrane protein TerC family
ND449_13610	COG0667	Aldo Keto reductase
ND449_13615	COG0477	Major facilitator Superfamily
ND449_13620	COG0204	Acyl-transferase
ND449_13620	COG0318	PFAM AMP-dependent synthetase and ligase
ND449_13630	COG1609	Transcriptional regulator
ND449_13640	COG0583	DNA-binding transcription factor activity
ND449_13645	COG0583	DNA-binding transcription factor activity
ND449_13700	COG2165	general secretion pathway protein
ND449_13710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND449_13740	COG1127	ABC transporter
ND449_13745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND449_13755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND449_13765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND449_13770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND449_13775	COG4974	Belongs to the 'phage' integrase family
ND449_13780	COG0716	FMN binding
ND449_13790	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND449_13800	COG1272	protein, Hemolysin III
ND449_13820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND449_13825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND449_13830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND449_13835	COG0006	proline dipeptidase activity
ND449_13845	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND449_13855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND449_13860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND449_13865	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND449_13880	COG1279	arginine transmembrane transporter activity
ND449_13890	COG0191	fructose-bisphosphate aldolase activity
ND449_13895	COG0126	phosphoglycerate kinase activity
ND449_13900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND449_13905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND449_13915	COG1166	arginine decarboxylase activity
ND449_13920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND449_13935	COG0640	Transcriptional regulator
ND449_13940	COG3091	SprT-like family
ND449_13945	COG2356	endonuclease I
ND449_13950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND449_13955	COG0189	ligase activity
ND449_13960	COG1678	Uncharacterized ACR, COG1678
ND449_13965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND449_13970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND449_13980	COG2805	Type II/IV secretion system protein
ND449_13985	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND449_13990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND449_13995	COG0762	integral membrane protein
ND449_14000	COG1872	DUF167
ND449_14005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND449_14010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND449_14025	COG3171	Protein conserved in bacteria
ND449_14035	COG1194	a g-specific adenine glycosylase
ND449_14040	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND449_14045	COG0741	lytic transglycosylase activity
ND449_14090	COG1105	Belongs to the carbohydrate kinase PfkB family
ND449_14095	COG1882	Formate acetyltransferase
ND449_14100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND449_14105	COG0814	amino acid
ND449_14120	COG1028	Short-chain dehydrogenase reductase Sdr
ND449_14125	COG3433	isochorismatase activity
ND449_14125	COG1535	isochorismatase
ND449_14130	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND449_14135	COG1169	isochorismate synthase
ND449_14140	COG4592	Periplasmic binding protein
ND449_14150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND449_14155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND449_14160	COG1120	ATPase activity
ND449_14170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND449_14175	COG3251	PFAM MbtH domain protein
ND449_14185	COG4774	siderophore transport
ND449_14190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND449_14215	COG4964	Belongs to the GSP D family
ND449_14275	COG0848	biopolymer transport protein
ND449_14280	COG0811	peptide transport
ND449_14285	COG0626	cystathionine gamma-synthase activity
ND449_14290	COG0586	Pfam SNARE associated Golgi protein
ND449_14295	COG2207	Transcriptional regulator
ND449_14300	COG1979	alcohol dehydrogenase
ND449_14305	COG0656	L-ascorbic acid biosynthetic process
ND449_14315	COG2132	Multicopper oxidase
ND449_14330	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND449_14335	COG0583	DNA-binding transcription factor activity
ND449_14340	COG0187	DNA topoisomerase II activity
ND449_14345	COG3150	esterase
ND449_14350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND449_14355	COG3151	Protein conserved in bacteria
ND449_14360	COG0494	nUDIX hydrolase
ND449_14365	COG1538	Outer membrane efflux protein
ND449_14370	COG5463	Belongs to the UPF0441 family
ND449_14375	COG0754	glutathionylspermidine amidase activity
ND449_14380	COG3384	dioxygenase
ND449_14385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND449_14400	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND449_14400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND449_14410	COG3025	triphosphatase activity
ND449_14415	COG4991	sh3 domain protein
ND449_14420	COG0617	tRNA 3'-terminal CCA addition
ND449_14425	COG1968	undecaprenyl-diphosphatase activity
ND449_14430	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND449_14435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND449_14440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND449_14445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND449_14450	COG0358	DNA primase activity
ND449_14480	COG1028	Short-chain dehydrogenase reductase Sdr
ND449_14510	COG0463	Glycosyl transferase, family 2
ND449_14545	COG3210	domain, Protein
ND449_14550	COG2831	hemolysin activation secretion protein
ND449_14555	COG1902	pentaerythritol trinitrate reductase activity
ND449_14555	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND449_14570	COG1451	nucleotide metabolic process
ND449_14575	COG0673	inositol 2-dehydrogenase activity
ND449_14580	COG0861	Integral membrane protein TerC family
ND449_14585	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND449_14595	COG2721	sulfolactate sulfo-lyase activity
ND449_14610	COG2271	Major facilitator Superfamily
ND449_14625	COG0586	Pfam SNARE associated Golgi protein
ND449_14640	COG4575	ribosome binding
ND449_14645	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND449_14655	COG2259	Doxx family
ND449_14660	COG0583	DNA-binding transcription factor activity
ND449_14665	COG1741	Belongs to the pirin family
ND449_14680	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ND449_14695	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND449_14700	COG2823	Periplasmic or secreted lipoprotein
ND449_14705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND449_14710	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND449_14715	COG5002	protein histidine kinase activity
ND449_14715	COG2198	Histidine kinase
ND449_14715	COG0784	Response regulator, receiver
ND449_14720	COG1242	4 iron, 4 sulfur cluster binding
ND449_14725	COG0069	glutamate synthase activity
ND449_14725	COG0067	glutamate synthase
ND449_14725	COG0070	glutamate synthase
ND449_14730	COG0493	'glutamate synthase
ND449_14740	COG2969	positive regulation of protein catabolic process
ND449_14745	COG0625	glutathione transferase activity
ND449_14750	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND449_14755	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND449_14760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND449_14765	COG3105	Protein conserved in bacteria
ND449_14770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND449_14780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND449_14785	COG5007	Belongs to the BolA IbaG family
ND449_14790	COG3113	response to antibiotic
ND449_14795	COG2854	intermembrane phospholipid transfer
ND449_14800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND449_14805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND449_14810	COG1127	ABC transporter
ND449_14815	COG0530	calcium, potassium:sodium antiporter activity
ND449_14820	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND449_14820	COG0517	IMP dehydrogenase activity
ND449_14825	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND449_14830	COG3117	lipopolysaccharide transmembrane transporter activity
ND449_14835	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND449_14840	COG1137	ATPase activity
ND449_14845	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND449_14865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND449_14870	COG0540	Belongs to the ATCase OTCase family
ND449_14875	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND449_14885	COG0366	Alpha amylase catalytic
ND449_14890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND449_14890	COG1263	PTS System
ND449_14900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND449_14910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND449_14915	COG3783	Cytochrome b(562)
ND449_14920	COG0312	modulator of DNA gyrase
ND449_14925	COG3028	Belongs to the UPF0307 family
ND449_14930	COG2732	(Barnase) inhibitor
ND449_14935	COG4290	ribonuclease
ND449_14945	COG1289	transmembrane transporter activity
ND449_14950	COG1566	PFAM secretion protein HlyD family protein
ND449_14960	COG0583	DNA-binding transcription factor activity
ND449_14965	COG0312	modulator of DNA gyrase
ND449_14970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND449_14975	COG3164	Protein of unknown function
ND449_14985	COG0424	maF-like protein
ND449_14990	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND449_14995	COG1792	Involved in formation and maintenance of cell shape
ND449_15000	COG1077	Cell shape determining protein MreB Mrl
ND449_15005	COG2200	EAL domain
ND449_15005	COG2199	diguanylate cyclase activity
ND449_15010	COG0604	alcohol dehydrogenase
ND449_15015	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND449_15020	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND449_15030	COG0511	ligase activity, forming carbon-carbon bonds
ND449_15035	COG0439	Biotin carboxylase
ND449_15040	COG3924	membrane
ND449_15045	COG4145	pantothenate transmembrane transporter activity
ND449_15050	COG2264	protein methyltransferase activity
ND449_15055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND449_15060	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND449_15070	COG1560	Kdo2-lipid A biosynthetic process
ND449_15080	COG1346	cytolysis
ND449_15085	COG1380	Effector of murein hydrolase LrgA
ND449_15090	COG0583	DNA-binding transcription factor activity
ND449_15095	COG0025	NhaP-type Na H and K H
ND449_15100	COG2252	PERMEase
ND449_15115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND449_15120	COG2315	Protein conserved in bacteria
ND449_15125	COG1448	Aminotransferase
ND449_15150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND449_15155	COG0735	belongs to the Fur family
ND449_15160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND449_15165	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND449_15170	COG2937	Belongs to the GPAT DAPAT family
ND449_15190	COG4580	involved in the transport of maltose and maltodextrins
ND449_15205	COG2182	Extracellular solute-binding protein
ND449_15210	COG1175	transmembrane transport
ND449_15215	COG3833	ABC-type maltose transport systems, permease component
ND449_15220	COG3223	Belongs to the PsiE family
ND449_15230	COG0527	aspartate kinase activity
ND449_15245	COG3328	transposase activity
ND449_15255	COG3328	transposase activity
ND449_15265	COG3328	transposase activity
ND449_15290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ND449_15370	COG0583	DNA-binding transcription factor activity
ND449_15410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND449_15450	COG0138	bifunctional purine biosynthesis protein purh
ND449_15455	COG0151	Belongs to the GarS family
ND449_15475	COG1515	deoxyribonuclease V activity
ND449_15480	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND449_15485	COG2816	NAD+ diphosphatase activity
ND449_15490	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND449_15505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND449_15510	COG2104	thiamine diphosphate biosynthetic process
ND449_15515	COG2022	thiamine diphosphate biosynthetic process
ND449_15525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND449_15530	COG0085	RNA polymerase activity
ND449_15535	COG0222	ribosome binding
ND449_15540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND449_15550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND449_15555	COG0250	Participates in transcription elongation, termination and antitermination
ND449_15600	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND449_15625	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND449_15630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND449_15635	COG1739	Uncharacterized protein family UPF0029
ND449_15645	COG1024	Enoyl-CoA hydratase
ND449_15645	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND449_15655	COG0543	2 iron, 2 sulfur cluster binding
ND449_15670	COG0250	Participates in transcription elongation, termination and antitermination
ND449_15685	COG0805	protein transport
ND449_15690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND449_15695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND449_15700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND449_15705	COG3165	ubiquinone biosynthetic process from chorismate
ND449_15710	COG2226	methyltransferase
ND449_15715	COG1322	Protein conserved in bacteria
ND449_15720	COG0586	Pfam SNARE associated Golgi protein
ND449_15725	COG1966	Carbon starvation protein
ND449_15740	COG0412	Dienelactone hydrolase
ND449_15745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND449_15750	COG0583	DNA-binding transcription factor activity
ND449_15755	COG0697	spore germination
ND449_15765	COG0584	glycerophosphoryl diester phosphodiesterase
ND449_15775	COG0395	ABC-type sugar transport system, permease component
ND449_15780	COG1175	transmembrane transport
ND449_15785	COG1653	transport
ND449_15820	COG0410	ABC transporter
ND449_15830	COG4177	L-phenylalanine transmembrane transporter activity
ND449_15850	COG1929	Belongs to the glycerate kinase type-1 family
ND449_15855	COG2610	gluconate transmembrane transporter activity
ND449_15860	COG3835	regulator
ND449_15870	COG2177	Part of the ABC transporter FtsEX involved in
ND449_15875	COG2884	Cell division ATP-binding protein ftsE
ND449_15880	COG0552	protein localization to endoplasmic reticulum
ND449_15880	COG0552	protein localization to endoplasmic reticulum
ND449_15885	COG0742	ribosomal rna small subunit methyltransferase
ND449_15890	COG3776	membrane
ND449_15905	COG3714	YhhN family
ND449_15920	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND449_15930	COG0247	lactate metabolic process
ND449_15940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND449_15950	COG2271	Major facilitator Superfamily
ND449_15955	COG0584	glycerophosphoryl diester phosphodiesterase
ND449_15960	COG0561	phosphatase activity
ND449_15965	COG2267	carboxylic ester hydrolase activity
ND449_15970	COG1280	lysine exporter protein (LysE YggA)
ND449_15975	COG0514	ATP-dependent DNA helicase (RecQ)
ND449_15980	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND449_15985	COG2050	protein possibly involved in aromatic compounds catabolism
ND449_16005	COG5564	TIM-barrel signal transduction protein
ND449_16010	COG5441	Belongs to the UPF0261 family
ND449_16020	COG0210	DNA helicase
ND449_16025	COG1011	Hydrolase
ND449_16030	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND449_16035	COG3159	Protein conserved in bacteria
ND449_16040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND449_16045	COG5567	small periplasmic lipoprotein
ND449_16055	COG3072	Adenylate cyclase
ND449_16060	COG0181	hydroxymethylbilane synthase activity
ND449_16065	COG1587	Uroporphyrinogen-III synthase
ND449_16070	COG2959	enzyme of heme biosynthesis
ND449_16075	COG3071	HemY protein
ND449_16125	COG2244	polysaccharide biosynthetic process
ND449_16130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND449_16135	COG0456	acetyltransferase
ND449_16140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND449_16145	COG1088	dTDP-glucose 4,6-dehydratase activity
ND449_16150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND449_16155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND449_16160	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND449_16165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND449_16170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND449_16175	COG3118	belongs to the thioredoxin family
ND449_16185	COG0248	Ppx GppA phosphatase
ND449_16195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND449_16210	COG3397	chitin binding
ND449_16220	COG0129	dihydroxy-acid dehydratase activity
ND449_16230	COG3978	acetolactate synthase activity
ND449_16250	COG3085	chromosome segregation
ND449_16255	COG0583	DNA-binding transcription factor activity
ND449_16330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND449_16340	COG0678	peroxiredoxin activity
ND449_16340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND449_16345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND449_16380	COG1629	transport
ND449_16385	COG0165	Argininosuccinate lyase
ND449_16390	COG0137	argininosuccinate synthase activity
ND449_16395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND449_16440	COG0527	aspartate kinase activity
ND449_16440	COG0460	homoserine dehydrogenase
ND449_16445	COG0626	cystathionine gamma-synthase activity
ND449_16450	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND449_16460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND449_16465	COG1609	Transcriptional regulator
ND449_16470	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND449_16475	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND449_16480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND449_16485	COG1575	Belongs to the MenA family. Type 1 subfamily
ND449_16490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND449_16495	COG3074	FtsZ-dependent cytokinesis
ND449_16500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND449_16505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND449_16510	COG1494	fructose-1,6-bisphosphatase
ND449_16515	COG2814	Major facilitator Superfamily
ND449_16525	COG3152	Membrane
ND449_16540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND449_16550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND449_16555	COG3678	ATP-independent chaperone mediated protein folding
ND449_16560	COG0745	RESPONSE REGULATOR receiver
ND449_16565	COG2205	protein histidine kinase activity
ND449_16570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND449_16575	COG1045	serine acetyltransferase
ND449_16580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND449_16585	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND449_16590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND449_16595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND449_16600	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND449_16605	COG4942	peptidase
ND449_16610	COG2861	carbohydrate metabolic process
ND449_16625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND449_16630	COG0859	PFAM glycosyl transferase family 9
ND449_16635	COG0859	PFAM glycosyl transferase family 9
ND449_16640	COG1519	Transferase
ND449_16660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND449_16665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND449_16670	COG2003	Belongs to the UPF0758 family
ND449_16675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND449_16680	COG0756	dUTP diphosphatase activity
ND449_16685	COG1309	transcriptional regulator
ND449_16690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND449_16695	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND449_16700	COG1561	YicC-like family, N-terminal region
ND449_16715	COG5001	Diguanylate cyclase
ND449_16720	COG1024	Enoyl-CoA hydratase
ND449_16725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND449_16735	COG2860	membrane
ND449_16740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND449_16750	COG1758	RNA polymerase activity
ND449_16755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND449_16760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND449_16765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND449_16770	COG0786	glutamate:sodium symporter activity
ND449_16775	COG2233	PERMEase
ND449_16780	COG2982	Protein involved in outer membrane biogenesis
ND449_16785	COG0456	acetyltransferase
ND449_16800	COG1011	Hydrolase
ND449_16815	COG3852	Histidine kinase
ND449_16825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND449_16835	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND449_16840	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND449_16840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND449_16845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND449_16850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND449_16855	COG3084	Protein conserved in bacteria
ND449_16865	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND449_16890	COG2186	Transcriptional regulator
ND449_16895	COG1609	Transcriptional regulator
ND449_16900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND449_16910	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND449_16915	COG1129	ABC transporter
ND449_16920	COG1869	D-ribose catabolic process
ND449_16925	COG3158	transport of potassium into the cell
ND449_16930	COG0714	Associated with various cellular activities
ND449_16935	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND449_16945	COG2502	aspartate--ammonia ligase
ND449_16950	COG1522	sequence-specific DNA binding
ND449_16955	COG0716	FMN binding
ND449_16960	COG0445	tRNA wobble uridine modification
ND449_16965	COG0357	Ribosomal RNA small subunit methyltransferase G
ND449_16970	COG3312	ion transport
ND449_16975	COG0356	it plays a direct role in the translocation of protons across the membrane
ND449_16985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND449_16995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND449_17000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND449_17010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND449_17025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND449_17030	COG0573	inorganic phosphate transmembrane transporter activity
ND449_17035	COG0581	inorganic phosphate transmembrane transporter activity
ND449_17045	COG0704	Plays a role in the regulation of phosphate uptake
ND449_17050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND449_17055	COG0765	amino acid transport
ND449_17060	COG0765	amino acid transport
ND449_17065	COG2252	PERMEase
ND449_17070	COG0840	transmembrane signaling receptor activity
ND449_17080	COG3121	Chaperone
ND449_17095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND449_17100	COG0706	membrane insertase activity
ND449_17110	COG0594	ribonuclease P activity
ND449_17115	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ND449_17180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ND449_17210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND449_17225	COG3549	Plasmid maintenance system killer
ND449_17230	COG3093	addiction module antidote protein HigA
ND449_17605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND449_17620	COG0741	lytic transglycosylase activity
ND449_17785	COG2944	sequence-specific DNA binding
ND449_17855	COG1192	Involved in chromosome partitioning
ND449_17930	COG1454	alcohol dehydrogenase