locus-tag	class	description
ND443_00010	COG0592	DNA-directed DNA polymerase activity
ND443_00020	COG0187	DNA topoisomerase II activity
ND443_00025	COG0561	phosphatase activity
ND443_00030	COG0823	Involved in the tonB-independent uptake of proteins
ND443_00035	COG5645	(Lipo)protein
ND443_00050	COG0569	domain protein
ND443_00050	COG2985	domain, Protein
ND443_00055	COG3977	Valine--pyruvate aminotransferase
ND443_00060	COG2885	chlorophyll binding
ND443_00080	COG2818	Glycosylase
ND443_00130	COG2213	PTS system mannitol-specific
ND443_00130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND443_00140	COG3722	fumarate hydratase activity
ND443_00150	COG2258	MOSC domain
ND443_00155	COG0840	transmembrane signaling receptor activity
ND443_00160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND443_00175	COG0437	4 iron, 4 sulfur cluster binding
ND443_00180	COG2864	formate dehydrogenase
ND443_00190	COG1921	L-seryl-tRNASec selenium transferase activity
ND443_00195	COG3276	selenocysteine insertion sequence binding
ND443_00200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND443_00210	COG3274	enterobacterial common antigen metabolic process
ND443_00220	COG0582	viral genome integration into host DNA
ND443_00255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND443_00260	COG2986	histidine ammonia-lyase
ND443_00280	COG2194	sulfuric ester hydrolase activity
ND443_00285	COG2197	response regulator
ND443_00290	COG3851	Histidine kinase
ND443_00295	COG2271	Major facilitator Superfamily
ND443_00305	COG0747	negative chemotaxis
ND443_00310	COG0601	transmembrane transport
ND443_00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND443_00320	COG0444	Belongs to the ABC transporter superfamily
ND443_00325	COG4608	Belongs to the ABC transporter superfamily
ND443_00330	COG2194	sulfuric ester hydrolase activity
ND443_00355	COG1215	transferase activity, transferring glycosyl groups
ND443_00360	COG1215	transferase activity, transferring glycosyl groups
ND443_00365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND443_00370	COG0457	Tetratricopeptide repeat
ND443_00370	COG3118	belongs to the thioredoxin family
ND443_00375	COG2199	diguanylate cyclase activity
ND443_00375	COG2200	EAL domain
ND443_00380	COG1301	dicarboxylic acid transport
ND443_00385	COG0612	Peptidase, M16
ND443_00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND443_00395	COG1942	4-Oxalocrotonate Tautomerase
ND443_00400	COG2200	EAL domain
ND443_00405	COG2134	cdp-diacylglycerol pyrophosphatase
ND443_00410	COG1295	ribonuclease BN
ND443_00420	COG1301	dicarboxylic acid transport
ND443_00425	COG0626	cystathionine gamma-synthase activity
ND443_00435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND443_00440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND443_00445	COG0339	signal peptide processing
ND443_00450	COG0742	ribosomal rna small subunit methyltransferase
ND443_00460	COG0589	response to stress
ND443_00470	COG0306	phosphate transporter
ND443_00475	COG2081	HI0933 family
ND443_00485	COG1247	-acetyltransferase
ND443_00495	COG1741	Belongs to the pirin family
ND443_00500	COG1609	Transcriptional regulator
ND443_00505	COG2610	gluconate transmembrane transporter activity
ND443_00510	COG3265	gluconokinase activity
ND443_00515	COG2095	MarC family integral membrane protein
ND443_00520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND443_00525	COG3275	phosphorelay sensor kinase activity
ND443_00530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND443_00535	COG1523	belongs to the glycosyl hydrolase 13 family
ND443_00540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND443_00545	COG0297	glycogen (starch) synthase activity
ND443_00550	COG0058	SHG alpha-glucan phosphorylase activity
ND443_00555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND443_00560	COG1349	DNA-binding transcription factor activity
ND443_00565	COG0705	Rhomboid family
ND443_00575	COG2909	trisaccharide binding
ND443_00580	COG0058	SHG alpha-glucan phosphorylase activity
ND443_00585	COG1640	4-alpha-glucanotransferase
ND443_00595	COG1040	competence protein
ND443_00600	COG0596	Alpha beta hydrolase
ND443_00620	COG1918	ferrous iron import across plasma membrane
ND443_00625	COG2183	response to ionizing radiation
ND443_00650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND443_00665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND443_00675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND443_00680	COG1011	Hydrolase
ND443_00690	COG0494	nUDIX hydrolase
ND443_00695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND443_00720	COG4796	Type ii and iii secretion system protein
ND443_00725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND443_00745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND443_00755	COG0180	Tryptophanyl-tRNA synthetase
ND443_00775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND443_00780	COG0402	S-adenosylhomocysteine deaminase activity
ND443_00785	COG0738	Major facilitator superfamily
ND443_00800	COG1609	Transcriptional regulator
ND443_00805	COG1486	melibiose metabolic process
ND443_00810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND443_00825	COG1289	transmembrane transporter activity
ND443_00830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND443_00835	COG1765	OsmC-like protein
ND443_00860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND443_00865	COG3954	Phosphoribulokinase
ND443_00875	COG0429	hydrolase of the alpha beta-hydrolase fold
ND443_00885	COG0859	PFAM glycosyl transferase family 9
ND443_00890	COG1216	Glycosyl transferase, family 2
ND443_00895	COG0488	(ABC) transporter
ND443_00900	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND443_00910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND443_00915	COG1047	Peptidyl-prolyl cis-trans
ND443_00925	COG0545	Peptidyl-prolyl cis-trans isomerase
ND443_00930	COG2964	Protein conserved in bacteria
ND443_00940	COG2923	Belongs to the DsrF TusC family
ND443_00945	COG2168	tRNA wobble position uridine thiolation
ND443_00950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND443_00955	COG0049	tRNA binding
ND443_00965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND443_00980	COG0051	transcription antitermination factor activity, RNA binding
ND443_00985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND443_00995	COG0089	rRNA binding
ND443_01000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND443_01005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND443_01010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND443_01020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND443_01025	COG0255	Belongs to the universal ribosomal protein uL29 family
ND443_01030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND443_01035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND443_01045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND443_01070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND443_01075	COG1841	ribosomal large subunit assembly
ND443_01080	COG0200	Binds to the 23S rRNA
ND443_01085	COG0201	protein transport
ND443_01090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND443_01095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND443_01105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND443_01115	COG0203	ribosomal protein L17
ND443_01120	COG0789	Transcriptional regulator
ND443_01125	COG3036	rescue of stalled ribosome
ND443_01130	COG1970	mechanosensitive ion channel activity
ND443_01140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND443_01140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND443_01145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND443_01150	COG0242	peptide deformylase activity
ND443_01155	COG0758	DNA mediated transformation
ND443_01160	COG2922	Belongs to the Smg family
ND443_01165	COG0551	DNA topoisomerase type I activity
ND443_01170	COG0009	L-threonylcarbamoyladenylate synthase
ND443_01180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND443_01210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND443_01215	COG3162	membrane
ND443_01220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND443_01225	COG1301	dicarboxylic acid transport
ND443_01235	COG2391	methyltransferase activity
ND443_01240	COG0425	Belongs to the sulfur carrier protein TusA family
ND443_01245	COG1086	Polysaccharide biosynthesis protein
ND443_01250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND443_01255	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND443_01260	COG2089	acid synthase
ND443_01280	COG2755	lipolytic protein G-D-S-L family
ND443_01280	COG1083	cytidylyl-transferase
ND443_01285	COG1028	Short-chain dehydrogenase reductase Sdr
ND443_01305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND443_01305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND443_01310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ND443_01330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND443_01350	COG1309	transcriptional regulator
ND443_01355	COG4232	protein-disulfide reductase activity
ND443_01365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND443_01395	COG1509	lysine 2,3-aminomutase activity
ND443_01405	COG3397	chitin binding
ND443_01425	COG3188	usher protein
ND443_01445	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND443_01450	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND443_01455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND443_01460	COG1053	succinate dehydrogenase
ND443_01465	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND443_01470	COG1511	domain protein
ND443_01470	COG3264	Mechanosensitive ion channel
ND443_01475	COG0688	phosphatidylethanolamine metabolic process
ND443_01480	COG1162	GTPase activity
ND443_01485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND443_01505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND443_01510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND443_01510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND443_01515	COG0802	atpase or kinase
ND443_01520	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND443_01530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND443_01540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND443_01545	COG0330	HflC and HflK could
ND443_01550	COG0330	HflC and HflK could
ND443_01555	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND443_01560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND443_01565	COG1959	2 iron, 2 sulfur cluster binding
ND443_01570	COG0557	exoribonuclease II activity
ND443_01575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND443_01595	COG3121	Chaperone
ND443_01600	COG3188	usher protein
ND443_01620	COG1073	alpha beta
ND443_01630	COG0360	Binds together with S18 to 16S ribosomal RNA
ND443_01635	COG2965	DNA replication, synthesis of RNA primer
ND443_01640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND443_01645	COG0359	binds to the 23S rRNA
ND443_01650	COG3061	Opacity-associated protein A
ND443_01655	COG0545	Peptidyl-prolyl cis-trans isomerase
ND443_01665	COG0737	Belongs to the 5'-nucleotidase family
ND443_01670	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND443_01675	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND443_01685	COG1253	flavin adenine dinucleotide binding
ND443_01690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND443_01695	COG0729	surface antigen
ND443_01700	COG2911	Protein conserved in bacteria
ND443_01705	COG2105	PFAM AIG2 family protein
ND443_01710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND443_01720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND443_01735	COG3423	Transcriptional regulator
ND443_01750	COG0142	geranyltranstransferase activity
ND443_01765	COG0697	spore germination
ND443_01770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND443_01775	COG0642	Histidine kinase
ND443_01780	COG0745	RESPONSE REGULATOR receiver
ND443_01785	COG2027	D-alanyl-D-alanine carboxypeptidase
ND443_01795	COG1534	Rna-binding protein
ND443_01800	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND443_01810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND443_01815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND443_01820	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND443_01840	COG0195	Participates in both transcription termination and antitermination
ND443_01850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND443_01865	COG1185	polyribonucleotide nucleotidyltransferase activity
ND443_01875	COG0513	Belongs to the DEAD box helicase family
ND443_01880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND443_01895	COG0826	peptidase U32
ND443_01900	COG0826	peptidase U32
ND443_01905	COG3154	lipid carrier protein
ND443_01910	COG3153	acetyltransferase
ND443_01915	COG2827	Endonuclease containing a URI domain
ND443_01920	COG0531	amino acid
ND443_01925	COG1982	Orn Lys Arg decarboxylase major
ND443_01935	COG3787	Belongs to the UPF0306 family
ND443_01940	COG0702	epimerase
ND443_01945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND443_01950	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND443_01955	COG3454	Phosphonate metabolism
ND443_01960	COG4778	phosphonate C-P lyase system protein PhnL
ND443_01965	COG4107	phosphonate C-P lyase system protein PhnK
ND443_01970	COG3627	carbon phosphorus lyase activity
ND443_01975	COG3626	phosphonate metabolism
ND443_01980	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND443_01985	COG3624	Phosphonate C-P lyase system protein PhnG
ND443_02005	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND443_02020	COG2927	DNA polymerase III (CHI subunit)
ND443_02025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND443_02030	COG0795	lipopolysaccharide-transporting ATPase activity
ND443_02035	COG0795	lipopolysaccharide-transporting ATPase activity
ND443_02075	COG3077	Addiction module antitoxin, RelB DinJ family
ND443_02180	COG5492	domain, Protein
ND443_02200	COG3119	arylsulfatase activity
ND443_02205	COG1349	DNA-binding transcription factor activity
ND443_02215	COG2222	sugar isomerase
ND443_02220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND443_02225	COG3715	PTS system
ND443_02230	COG3716	PTS system mannose fructose sorbose family IID component
ND443_02240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND443_02250	COG1028	Short-chain dehydrogenase reductase Sdr
ND443_02260	COG0641	radical SAM
ND443_02265	COG3119	arylsulfatase activity
ND443_02290	COG0859	PFAM glycosyl transferase family 9
ND443_02305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND443_02310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND443_02320	COG2376	Dihydroxyacetone kinase
ND443_02325	COG1461	Dihydroxyacetone kinase
ND443_02330	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND443_02330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND443_02330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND443_02370	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND443_02385	COG2823	Periplasmic or secreted lipoprotein
ND443_02395	COG4667	esterase of the alpha-beta hydrolase superfamily
ND443_02400	COG0084	hydrolase, TatD family'
ND443_02405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND443_02420	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND443_02430	COG3726	membrane protein affecting hemolysin expression
ND443_02435	COG0560	Phosphoserine phosphatase
ND443_02450	COG0488	(ABC) transporter
ND443_02475	COG0741	lytic transglycosylase activity
ND443_02480	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND443_02485	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND443_02490	COG0406	alpha-ribazole phosphatase activity
ND443_02495	COG3708	Transcriptional regulator
ND443_02495	COG2207	Transcriptional regulator
ND443_02500	COG3045	CreA protein
ND443_02505	COG0745	RESPONSE REGULATOR receiver
ND443_02540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND443_02545	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND443_02550	COG0477	Major facilitator Superfamily
ND443_02560	COG1584	GPR1 FUN34 yaaH family protein
ND443_02565	COG0443	Heat shock 70 kDa protein
ND443_02575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND443_02580	COG0583	DNA-binding transcription factor activity
ND443_02590	COG0196	riboflavin kinase activity
ND443_02600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND443_02605	COG1047	Peptidyl-prolyl cis-trans
ND443_02610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND443_02625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND443_02635	COG2966	Psort location CytoplasmicMembrane, score
ND443_02660	COG2967	ApaG domain
ND443_02665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND443_02670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND443_02680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND443_02690	COG0564	pseudouridine synthase activity
ND443_02695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND443_02700	COG0417	DNA replication proofreading
ND443_02705	COG0586	Pfam SNARE associated Golgi protein
ND443_02715	COG1178	ABC-type Fe3 transport system permease component
ND443_02720	COG4143	(ABC) transporter
ND443_02735	COG2814	Major facilitator Superfamily
ND443_02745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND443_02750	COG0473	3-isopropylmalate dehydrogenase activity
ND443_02765	COG1022	Amp-dependent synthetase and ligase
ND443_02770	COG0028	Belongs to the TPP enzyme family
ND443_02795	COG0275	rRNA processing
ND443_02800	COG3116	cell division
ND443_02805	COG0768	penicillin binding
ND443_02810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND443_02815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND443_02830	COG0772	Belongs to the SEDS family
ND443_02835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND443_02840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND443_02850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND443_02855	COG0849	cell division
ND443_02860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND443_02885	COG0494	nUDIX hydrolase
ND443_02905	COG0516	GMP reductase activity
ND443_02910	COG1459	type II secretion system
ND443_02915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND443_02920	COG4969	Belongs to the N-Me-Phe pilin family
ND443_02935	COG3725	Membrane protein required for beta-lactamase induction
ND443_02940	COG1113	amino acid transport
ND443_02945	COG2186	Transcriptional regulator
ND443_02950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND443_02955	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND443_02960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND443_02970	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND443_02975	COG3112	Uncharacterised protein family (UPF0231)
ND443_02990	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND443_03000	COG2132	Multicopper oxidase
ND443_03010	COG0288	reversible hydration of carbon dioxide
ND443_03015	COG1131	(ABC) transporter
ND443_03020	COG0842	Transport permease protein
ND443_03025	COG0726	polysaccharide deacetylase
ND443_03030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND443_03035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND443_03040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND443_03045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND443_03050	COG0617	tRNA 3'-terminal CCA addition
ND443_03065	COG1489	DNA binding
ND443_03070	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND443_03075	COG1643	Atp-dependent helicase
ND443_03080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND443_03085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND443_03095	COG0316	Belongs to the HesB IscA family
ND443_03100	COG2860	membrane
ND443_03110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND443_03115	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND443_03120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND443_03130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND443_03135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND443_03140	COG3956	TIGRFAM MazG family protein
ND443_03145	COG0504	CTP synthase activity
ND443_03155	COG0602	queuosine metabolic process
ND443_03160	COG0720	synthase
ND443_03165	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND443_03175	COG0175	sulfate reduction
ND443_03190	COG2234	aminopeptidase activity
ND443_03195	COG1648	precorrin-2 dehydrogenase activity
ND443_03195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND443_03200	COG0175	sulfate reduction
ND443_03205	COG2895	sulfate adenylyltransferase (ATP) activity
ND443_03210	COG0529	Catalyzes the synthesis of activated sulfate
ND443_03220	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND443_03230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND443_03235	COG0585	pseudouridine synthase activity
ND443_03240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND443_03250	COG4942	peptidase
ND443_03250	COG1388	LysM domain
ND443_03255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND443_03260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND443_03330	COG0784	Response regulator, receiver
ND443_03330	COG2205	protein histidine kinase activity
ND443_03350	COG0741	lytic transglycosylase activity
ND443_03480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND443_03500	COG3397	chitin binding
ND443_03510	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ND443_03555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND443_03565	COG3031	protein transport across the cell outer membrane
ND443_03590	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND443_03590	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND443_03605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND443_03610	COG2137	regulation of response to DNA damage stimulus
ND443_03615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND443_03620	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND443_03650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND443_03655	COG1238	metal cluster binding
ND443_03660	COG2918	glutathione biosynthetic process
ND443_03665	COG1854	S-ribosylhomocysteine lyase activity
ND443_03670	COG4536	flavin adenine dinucleotide binding
ND443_03675	COG4137	Cytochrome C assembly protein
ND443_03680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND443_03690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND443_03695	COG0336	Belongs to the RNA methyltransferase TrmD family
ND443_03700	COG0335	large ribosomal subunit rRNA binding
ND443_03705	COG3137	Salt-induced outer membrane protein
ND443_03710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND443_03715	COG3279	Response regulator of the LytR AlgR family
ND443_03720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND443_03725	COG1605	Chorismate mutase
ND443_03725	COG0287	Prephenate dehydrogenase
ND443_03730	COG1605	Chorismate mutase
ND443_03730	COG0077	Prephenate dehydratase
ND443_03740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND443_03745	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND443_03750	COG0564	pseudouridine synthase activity
ND443_03755	COG1496	oxidoreductase activity
ND443_03760	COG0542	response to heat
ND443_03795	COG3021	interspecies interaction between organisms
ND443_03800	COG0741	lytic transglycosylase activity
ND443_03800	COG1388	LysM domain
ND443_03810	COG2226	methyltransferase
ND443_03820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND443_03830	COG1960	acyl-CoA dehydrogenase activity
ND443_03835	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND443_03840	COG0121	glutamine amidotransferase
ND443_03845	COG3034	peptidoglycan biosynthetic process
ND443_03855	COG1805	sodium ion transport
ND443_03860	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND443_03865	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND443_03870	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND443_03880	COG1477	protein flavinylation
ND443_03885	COG2991	Protein conserved in bacteria
ND443_03895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND443_03900	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND443_03905	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND443_03910	COG1073	alpha beta
ND443_03925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND443_03960	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND443_03980	COG4126	flavin adenine dinucleotide binding
ND443_03990	COG2974	May be involved in recombination
ND443_03995	COG1940	carbohydrate kinase activity
ND443_04000	COG0419	ATPase involved in DNA repair
ND443_04005	COG0420	3'-5' exonuclease activity
ND443_04010	COG0745	RESPONSE REGULATOR receiver
ND443_04015	COG5002	protein histidine kinase activity
ND443_04030	COG1113	amino acid transport
ND443_04035	COG0366	Alpha amylase catalytic
ND443_04040	COG0300	oxidoreductase activity
ND443_04045	COG0450	alkyl hydroperoxide reductase
ND443_04050	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND443_04065	COG1862	Preprotein translocase
ND443_04070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND443_04075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND443_04080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND443_04085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND443_04085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND443_04090	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND443_04100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND443_04105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND443_04110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND443_04115	COG0142	geranyltranstransferase activity
ND443_04150	COG0693	protein deglycase activity
ND443_04155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND443_04160	COG1666	GTP binding
ND443_04165	COG2814	Major facilitator Superfamily
ND443_04175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND443_04180	COG1845	cytochrome c oxidase, subunit III
ND443_04185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND443_04190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND443_04200	COG2223	nitrite transmembrane transporter activity
ND443_04205	COG3056	Lipoprotein
ND443_04210	COG0271	Belongs to the BolA IbaG family
ND443_04220	COG0740	serine-type endopeptidase activity
ND443_04225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND443_04230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND443_04235	COG0776	regulation of translation
ND443_04240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND443_04245	COG1555	photosystem II stabilization
ND443_04250	COG0824	Thioesterase
ND443_04255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND443_04260	COG4533	DNA binding
ND443_04275	COG1522	sequence-specific DNA binding
ND443_04280	COG1132	(ABC) transporter
ND443_04285	COG1132	(ABC) transporter
ND443_04290	COG0347	Belongs to the P(II) protein family
ND443_04295	COG0004	ammonium transporteR
ND443_04300	COG1946	Acyl-CoA thioesterase
ND443_04305	COG3695	enzyme binding
ND443_04330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND443_04335	COG0254	rRNA binding
ND443_04340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND443_04345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND443_04350	COG1309	transcriptional regulator
ND443_04355	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND443_04360	COG1196	nuclear chromosome segregation
ND443_04360	COG3264	Mechanosensitive ion channel
ND443_04375	COG2832	Protein of unknown function (DUF454)
ND443_04380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND443_04420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND443_04425	COG0326	Molecular chaperone. Has ATPase activity
ND443_04440	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND443_04445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND443_04450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND443_04450	COG4651	solute:proton antiporter activity
ND443_04455	COG0737	Belongs to the 5'-nucleotidase family
ND443_04460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND443_04465	COG3735	TraB family
ND443_04470	COG2217	Heavy metal translocating P-type atpase
ND443_04475	COG0789	Transcriptional regulator
ND443_04480	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND443_04485	COG0330	HflC and HflK could
ND443_04490	COG3118	belongs to the thioredoxin family
ND443_04495	COG0300	oxidoreductase activity
ND443_04500	COG2755	lipolytic protein G-D-S-L family
ND443_04505	COG4181	ATPase activity
ND443_04510	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND443_04515	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND443_04520	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND443_04525	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND443_04530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND443_04555	COG3188	usher protein
ND443_04560	COG3121	Chaperone
ND443_04590	COG2501	S4 domain
ND443_04595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND443_04610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND443_04615	COG1393	Belongs to the ArsC family
ND443_04625	COG1022	Amp-dependent synthetase and ligase
ND443_04650	COG3038	cytochrome b561
ND443_04680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND443_04690	COG1215	transferase activity, transferring glycosyl groups
ND443_04710	COG3250	beta-galactosidase activity
ND443_04725	COG1309	transcriptional regulator
ND443_04755	COG2197	response regulator
ND443_04760	COG1278	Cold shock
ND443_04780	COG3706	GGDEF domain
ND443_04790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND443_04800	COG2921	Belongs to the UPF0250 family
ND443_04805	COG1686	Belongs to the peptidase S11 family
ND443_04810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND443_04815	COG0772	Belongs to the SEDS family
ND443_04820	COG0768	penicillin binding
ND443_04825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND443_04830	COG0799	negative regulation of ribosome biogenesis
ND443_04835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND443_04840	COG1466	dna polymerase III delta subunit
ND443_04845	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND443_04855	COG2888	peptidyl-tyrosine sulfation
ND443_04860	COG1126	abc transporter atp-binding protein
ND443_04865	COG0765	amino acid transport
ND443_04870	COG0765	amino acid transport
ND443_04880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND443_04885	COG4535	Mg2 and Co2 transporter CorC
ND443_04890	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND443_04895	COG1702	phosphate starvation-inducible protein PhoH
ND443_04900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND443_04905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND443_04940	COG0367	asparagine synthase
ND443_04945	COG0647	UMP catabolic process
ND443_04950	COG1940	carbohydrate kinase activity
ND443_04950	COG1846	Transcriptional regulator
ND443_04955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND443_04965	COG2190	(PTS) system
ND443_04965	COG1263	PTS System
ND443_04965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND443_04990	COG0735	belongs to the Fur family
ND443_05000	COG0840	transmembrane signaling receptor activity
ND443_05010	COG0596	Alpha beta hydrolase
ND443_05015	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND443_05020	COG0033	Phosphoglucomutase
ND443_05030	COG0745	RESPONSE REGULATOR receiver
ND443_05035	COG2205	protein histidine kinase activity
ND443_05040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND443_05045	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND443_05065	COG3272	Protein of unknown function (DUF1722)
ND443_05070	COG0415	Belongs to the DNA photolyase family
ND443_05075	COG5212	phosphodiesterase
ND443_05080	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND443_05085	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND443_05090	COG1984	allophanate hydrolase subunit 2
ND443_05095	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND443_05130	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND443_05135	COG1053	succinate dehydrogenase
ND443_05140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND443_05145	COG0567	Dehydrogenase, E1 component
ND443_05150	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND443_05155	COG0045	succinate-CoA ligase (ADP-forming) activity
ND443_05160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND443_05165	COG0737	Belongs to the 5'-nucleotidase family
ND443_05170	COG1271	oxidase subunit
ND443_05175	COG1294	oxidase, subunit
ND443_05180	COG4890	Cyd operon protein YbgT
ND443_05185	COG3790	cyd operon protein YbgE
ND443_05190	COG0824	Thioesterase
ND443_05195	COG0811	peptide transport
ND443_05200	COG0848	biopolymer transport protein
ND443_05205	COG3064	Membrane
ND443_05205	COG3064	Membrane
ND443_05210	COG0823	Involved in the tonB-independent uptake of proteins
ND443_05215	COG2885	chlorophyll binding
ND443_05220	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND443_05250	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND443_05260	COG2205	protein histidine kinase activity
ND443_05260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND443_05270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND443_05275	COG0588	phosphoglycerate mutase activity
ND443_05285	COG2017	converts alpha-aldose to the beta-anomer
ND443_05295	COG1085	galactose-1-phosphate uridylyltransferase
ND443_05300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND443_05315	COG2005	Transcriptional regulator
ND443_05315	COG3585	molybdate ion transport
ND443_05325	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND443_05330	COG4149	molybdate abc transporter
ND443_05340	COG0561	phosphatase activity
ND443_05345	COG2706	6-phosphogluconolactonase activity
ND443_05360	COG0156	8-amino-7-oxononanoate synthase activity
ND443_05365	COG2226	methyltransferase
ND443_05380	COG0556	nucleotide-excision repair
ND443_05385	COG4628	conserved protein (DUF2132)
ND443_05400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND443_05405	COG1120	ATPase activity
ND443_05410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND443_05415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND443_05425	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND443_05430	COG0314	molybdopterin synthase activity
ND443_05435	COG0670	Belongs to the BI1 family
ND443_05440	COG0842	Transport permease protein
ND443_05445	COG0842	Transport permease protein
ND443_05450	COG1131	(ABC) transporter
ND443_05455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND443_05460	COG1309	transcriptional regulator
ND443_05465	COG0513	Belongs to the DEAD box helicase family
ND443_05470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND443_05480	COG1686	Belongs to the peptidase S11 family
ND443_05485	COG0277	FAD linked oxidase domain protein
ND443_05505	COG2261	transglycosylase associated protein
ND443_05515	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND443_05525	COG3639	organic phosphonate transmembrane transporter activity
ND443_05530	COG4807	Protein conserved in bacteria
ND443_05535	COG2897	thiosulfate sulfurtransferase activity
ND443_05540	COG1732	Glycine betaine
ND443_05545	COG1174	glycine betaine transport
ND443_05550	COG1125	glycine betaine transport
ND443_05555	COG1174	glycine betaine transport
ND443_05560	COG0531	amino acid
ND443_05565	COG1982	Orn Lys Arg decarboxylase major
ND443_05575	COG0697	spore germination
ND443_05590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND443_05595	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND443_05600	COG1126	abc transporter atp-binding protein
ND443_05605	COG0765	amino acid transport
ND443_05610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND443_05630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND443_05635	COG2239	Acts as a magnesium transporter
ND443_05640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND443_05645	COG0488	(ABC) transporter
ND443_05650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND443_05655	COG0303	'Molybdopterin
ND443_05675	COG0583	DNA-binding transcription factor activity
ND443_05680	COG0477	Major facilitator Superfamily
ND443_05685	COG0302	gtp cyclohydrolase
ND443_05690	COG2311	Membrane
ND443_05715	COG2949	membrane
ND443_05720	COG0281	malic enzyme
ND443_05730	COG0583	DNA-binding transcription factor activity
ND443_05740	COG1346	cytolysis
ND443_05745	COG1380	Effector of murein hydrolase LrgA
ND443_05755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND443_05755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND443_05760	COG0489	protein tyrosine kinase activity
ND443_05765	COG0572	uridine kinase
ND443_05770	COG0717	Belongs to the dCTP deaminase family
ND443_05775	COG2982	Protein involved in outer membrane biogenesis
ND443_05780	COG3069	C4-dicarboxylate transmembrane transporter activity
ND443_05785	COG1253	flavin adenine dinucleotide binding
ND443_05790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND443_05795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND443_05800	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND443_05810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND443_05810	COG0140	phosphoribosyl-ATP diphosphatase activity
ND443_05820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND443_05830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND443_05830	COG0131	Imidazoleglycerol-phosphate dehydratase
ND443_05835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND443_05840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND443_05855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND443_05860	COG0625	glutathione transferase activity
ND443_05875	COG0626	cystathionine gamma-synthase activity
ND443_05885	COG1686	Belongs to the peptidase S11 family
ND443_05890	COG1760	l-serine dehydratase
ND443_05895	COG0814	amino acid
ND443_05900	COG1349	DNA-binding transcription factor activity
ND443_05910	COG0671	phosphoesterase, PA-phosphatase related
ND443_05920	COG0569	domain protein
ND443_05920	COG2985	domain, Protein
ND443_05940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND443_05945	COG3842	ATPase activity
ND443_05950	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND443_05955	COG1177	transmembrane transport
ND443_05970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND443_05975	COG4160	amino acid transport
ND443_05980	COG4215	(ABC) transporter
ND443_05985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND443_05990	COG1126	abc transporter atp-binding protein
ND443_06000	COG0393	Putative heavy-metal-binding
ND443_06005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND443_06010	COG0702	epimerase
ND443_06015	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND443_06020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND443_06025	COG1151	hydroxylamine reductase activity
ND443_06030	COG2431	L-lysine efflux transmembrane transporter activity
ND443_06035	COG3593	DNA synthesis involved in DNA repair
ND443_06040	COG2990	Protein conserved in bacteria
ND443_06045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND443_06055	COG1278	Cold shock
ND443_06060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND443_06065	COG0542	response to heat
ND443_06070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND443_06080	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND443_06090	COG0492	ferredoxin-NADP+ reductase activity
ND443_06095	COG1522	sequence-specific DNA binding
ND443_06100	COG1674	ftsk spoiiie
ND443_06100	COG3107	peptidoglycan biosynthetic process
ND443_06105	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND443_06110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND443_06115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND443_06120	COG2814	Major facilitator Superfamily
ND443_06125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND443_06130	COG1882	Formate acetyltransferase
ND443_06135	COG2116	formate transmembrane transporter activity
ND443_06140	COG1944	ATP diphosphatase activity
ND443_06145	COG0252	asparaginase activity
ND443_06155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND443_06165	COG0539	negative regulation of cytoplasmic translation
ND443_06175	COG2333	competence protein COMEC
ND443_06175	COG0658	competence protein
ND443_06185	COG1663	tetraacyldisaccharide 4'-kinase activity
ND443_06190	COG5383	Protein conserved in bacteria
ND443_06200	COG1278	Cold shock
ND443_06205	COG2835	tetraacyldisaccharide 4'-kinase activity
ND443_06210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND443_06215	COG3173	Aminoglycoside phosphotransferase
ND443_06220	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND443_06225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND443_06230	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND443_06240	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND443_06245	COG2989	Protein conserved in bacteria
ND443_06250	COG3108	Peptidase M15
ND443_06255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND443_06260	COG1448	Aminotransferase
ND443_06275	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND443_06280	COG0308	aminopeptidase N
ND443_06285	COG0167	dihydroorotate dehydrogenase activity
ND443_06295	COG3217	Mosc domain protein beta barrel domain protein
ND443_06295	COG0633	Ferredoxin
ND443_06300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND443_06300	COG0116	Belongs to the methyltransferase superfamily
ND443_06305	COG0488	(ABC) transporter
ND443_06310	COG2995	paraquat-inducible protein a
ND443_06315	COG3008	intermembrane lipid transfer
ND443_06315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND443_06320	COG3009	Protein conserved in bacteria
ND443_06325	COG3130	regulation of translation
ND443_06330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND443_06335	COG1067	ATP-dependent peptidase activity
ND443_06340	COG3120	sequence-specific DNA binding
ND443_06350	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND443_06355	COG3070	regulator of competence-specific genes
ND443_06360	COG1289	transmembrane transporter activity
ND443_06365	COG3304	Inner membrane component domain
ND443_06370	COG0210	DNA helicase
ND443_06375	COG1803	Methylglyoxal synthase
ND443_06385	COG1832	CoA-binding protein
ND443_06390	COG3785	DNA binding
ND443_06395	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND443_06400	COG1254	Belongs to the acylphosphatase family
ND443_06405	COG2920	part of a sulfur-relay system
ND443_06415	COG0288	reversible hydration of carbon dioxide
ND443_06435	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND443_06440	COG2943	transferase activity, transferring hexosyl groups
ND443_06455	COG0675	Transposase, IS605 OrfB family
ND443_06470	COG1560	Kdo2-lipid A biosynthetic process
ND443_06480	COG0628	permease
ND443_06505	COG0418	dihydroorotase activity
ND443_06510	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND443_06520	COG1530	ribonuclease E activity
ND443_06525	COG0564	pseudouridine synthase activity
ND443_06530	COG0424	maF-like protein
ND443_06535	COG1399	metal-binding, possibly nucleic acid-binding protein
ND443_06540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND443_06550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND443_06555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND443_06565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND443_06570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND443_06575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND443_06580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND443_06585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND443_06590	COG0470	DNA polymerase III
ND443_06595	COG0084	hydrolase, TatD family'
ND443_06600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND443_06600	COG1263	PTS System
ND443_06605	COG0537	adenosine 5'-monophosphoramidase activity
ND443_06610	COG5633	Lipoprotein
ND443_06615	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND443_06630	COG3150	esterase
ND443_06635	COG1252	NADH dehydrogenase
ND443_06640	COG3134	Outer membrane lipoprotein
ND443_06645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND443_06650	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND443_06660	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND443_06680	COG2850	peptidyl-arginine hydroxylation
ND443_06685	COG2205	protein histidine kinase activity
ND443_06690	COG0745	RESPONSE REGULATOR receiver
ND443_06700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND443_06705	COG2915	High frequency lysogenization protein hflD homolog
ND443_06710	COG0482	sulfurtransferase activity
ND443_06720	COG1187	pseudouridine synthase activity
ND443_06725	COG0538	isocitrate dehydrogenase activity
ND443_06730	COG2771	luxR family
ND443_06735	COG3916	Acyl-homoserine-lactone synthase
ND443_06740	COG2723	6-phospho-beta-galactosidase activity
ND443_06750	COG0339	signal peptide processing
ND443_06755	COG0840	transmembrane signaling receptor activity
ND443_06780	COG0675	Transposase, IS605 OrfB family
ND443_06790	COG4565	transcriptional regulatory protein
ND443_06795	COG3290	protein histidine kinase activity
ND443_06800	COG0471	metal ion transport
ND443_06840	COG4977	sequence-specific DNA binding
ND443_06845	COG1702	phosphate starvation-inducible protein PhoH
ND443_06850	COG0387	Pfam Sodium calcium exchanger
ND443_06855	COG2375	cellular response to nickel ion
ND443_06860	COG3850	Histidine kinase
ND443_06870	COG1294	oxidase, subunit
ND443_06875	COG1271	oxidase subunit
ND443_06880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND443_06885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND443_06890	COG3138	arginine N-succinyltransferase
ND443_06900	COG3724	N-succinylarginine dihydrolase activity
ND443_06920	COG1228	amidohydrolase
ND443_06930	COG0402	S-adenosylhomocysteine deaminase activity
ND443_06950	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND443_06955	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND443_06960	COG3383	formate dehydrogenase (NAD+) activity
ND443_06965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND443_06970	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND443_06980	COG3260	NADH ubiquinone oxidoreductase 20
ND443_06985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND443_06990	COG3261	NADH dehydrogenase
ND443_06990	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND443_06995	COG0650	Formate hydrogenlyase subunit 4
ND443_07000	COG0651	ATP synthesis coupled electron transport
ND443_07005	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND443_07015	COG0375	protein maturation
ND443_07020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND443_07025	COG0298	carbon dioxide binding
ND443_07030	COG0409	Hydrogenase expression formation protein
ND443_07035	COG0309	Hydrogenase expression formation protein (HypE)
ND443_07070	COG2207	Transcriptional regulator
ND443_07070	COG3708	Transcriptional regulator
ND443_07075	COG0012	GTP binding
ND443_07085	COG0193	aminoacyl-tRNA hydrolase activity
ND443_07095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND443_07105	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND443_07110	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND443_07115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND443_07120	COG2890	protein-(glutamine-N5) methyltransferase activity
ND443_07135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND443_07140	COG0659	secondary active sulfate transmembrane transporter activity
ND443_07145	COG3706	GGDEF domain
ND443_07170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND443_07180	COG3381	protein complex oligomerization
ND443_07200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND443_07210	COG0673	inositol 2-dehydrogenase activity
ND443_07215	COG0728	peptidoglycan biosynthetic process
ND443_07240	COG3102	Protein conserved in bacteria
ND443_07245	COG3142	Participates in the control of copper homeostasis
ND443_07260	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND443_07265	COG1801	Protein of unknown function DUF72
ND443_07275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND443_07280	COG0494	nUDIX hydrolase
ND443_07290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND443_07300	COG2255	four-way junction helicase activity
ND443_07305	COG3104	oligopeptide transport
ND443_07310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND443_07315	COG1121	(ABC) transporter
ND443_07320	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND443_07325	COG0739	heme binding
ND443_07330	COG1560	Kdo2-lipid A biosynthetic process
ND443_07335	COG0469	pyruvate kinase activity
ND443_07340	COG1737	Transcriptional regulator
ND443_07345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND443_07350	COG0800	Aldolase
ND443_07360	COG2076	Multidrug Resistance protein
ND443_07365	COG0251	oxidation-reduction process
ND443_07370	COG1199	ATP-dependent helicase activity
ND443_07375	COG1214	PFAM Peptidase M22, glycoprotease
ND443_07380	COG3065	identical protein binding
ND443_07385	COG0318	PFAM AMP-dependent synthetase and ligase
ND443_07390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND443_07395	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND443_07400	COG2894	cell division
ND443_07405	COG0850	regulation of cytokinetic process
ND443_07410	COG3100	YcgL domain-containing protein
ND443_07415	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND443_07420	COG2983	Belongs to the UPF0260 family
ND443_07440	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND443_07450	COG2719	SpoVR family
ND443_07455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND443_07460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND443_07465	COG2814	Major facilitator Superfamily
ND443_07475	COG2202	Pas domain
ND443_07475	COG2200	EAL domain
ND443_07475	COG2199	diguanylate cyclase activity
ND443_07495	COG2718	Belongs to the UPF0229 family
ND443_07500	COG2766	serine protein kinase
ND443_07510	COG3713	MltA-interacting MipA family protein
ND443_07515	COG2194	sulfuric ester hydrolase activity
ND443_07530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND443_07535	COG3139	Protein of unknown function (DUF1315)
ND443_07540	COG1335	isochorismatase
ND443_07545	COG0252	asparaginase activity
ND443_07550	COG0616	signal peptide processing
ND443_07555	COG0778	Nitroreductase
ND443_07565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND443_07575	COG0494	nUDIX hydrolase
ND443_07580	COG0708	Exodeoxyribonuclease III
ND443_07610	COG0788	formyltetrahydrofolate deformylase activity
ND443_07620	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND443_07625	COG0745	RESPONSE REGULATOR receiver
ND443_07645	COG1012	belongs to the aldehyde dehydrogenase family
ND443_07645	COG1454	alcohol dehydrogenase
ND443_07655	COG2095	MarC family integral membrane protein
ND443_07660	COG4166	transmembrane transport
ND443_07675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND443_07690	COG3099	Belongs to the UPF0263 family
ND443_07695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND443_07715	COG2350	Protein conserved in bacteria
ND443_07730	COG3710	Transcriptional regulator
ND443_07765	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND443_07790	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND443_07795	COG3047	cAMP biosynthetic process
ND443_07810	COG0133	tryptophan synthase activity
ND443_07815	COG0135	phosphoribosylanthranilate isomerase activity
ND443_07815	COG0134	indole-3-glycerol-phosphate synthase activity
ND443_07825	COG0512	Glutamine amidotransferase of anthranilate synthase
ND443_07835	COG0613	PHP domain protein
ND443_07840	COG0009	L-threonylcarbamoyladenylate synthase
ND443_07860	COG1187	pseudouridine synthase activity
ND443_07870	COG1028	Short-chain dehydrogenase reductase Sdr
ND443_07875	COG0616	signal peptide processing
ND443_07890	COG0583	DNA-binding transcription factor activity
ND443_07905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND443_07915	COG0671	phosphoesterase, PA-phosphatase related
ND443_07920	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND443_07925	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND443_07945	COG0023	Translation Initiation Factor
ND443_07955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND443_07960	COG3447	MASE1 domain protein
ND443_07960	COG5001	Diguanylate cyclase
ND443_07960	COG5002	protein histidine kinase activity
ND443_07965	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND443_07970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND443_07980	COG4659	FMN binding
ND443_07990	COG2207	Transcriptional regulator
ND443_07990	COG3708	Transcriptional regulator
ND443_08005	COG4657	Part of a membrane complex involved in electron transport
ND443_08015	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND443_08025	COG0673	inositol 2-dehydrogenase activity
ND443_08030	COG0385	Bile acid
ND443_08035	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND443_08040	COG5339	Protein conserved in bacteria
ND443_08045	COG1482	cell wall glycoprotein biosynthetic process
ND443_08050	COG0114	fumarate hydratase activity
ND443_08060	COG1940	carbohydrate kinase activity
ND443_08065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND443_08085	COG1742	UPF0060 membrane protein
ND443_08090	COG4221	oxidoreductase activity
ND443_08095	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND443_08115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND443_08155	COG1011	Hydrolase
ND443_08165	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND443_08170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND443_08175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND443_08180	COG0589	response to stress
ND443_08210	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND443_08215	COG3623	hexulose-6-phosphate isomerase
ND443_08220	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND443_08225	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND443_08235	COG0531	amino acid
ND443_08245	COG0745	RESPONSE REGULATOR receiver
ND443_08250	COG2205	protein histidine kinase activity
ND443_08265	COG2207	Transcriptional regulator
ND443_08270	COG1881	PFAM PEBP family protein
ND443_08280	COG3591	Belongs to the peptidase S1B family
ND443_08285	COG1643	Atp-dependent helicase
ND443_08290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND443_08295	COG3784	Protein of unknown function (DUF1318)
ND443_08310	COG2911	Protein conserved in bacteria
ND443_08315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND443_08320	COG3187	Heat shock protein
ND443_08325	COG3042	response to heat
ND443_08330	COG1285	pathogenesis
ND443_08340	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND443_08340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND443_08340	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND443_08340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND443_08355	COG4166	transmembrane transport
ND443_08360	COG2866	Carboxypeptidase
ND443_08365	COG4948	Mandelate Racemase Muconate Lactonizing
ND443_08370	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND443_08380	COG5642	Protein of unknown function (DUF2384)
ND443_08385	COG5654	RES domain protein
ND443_08390	COG3768	UPF0283 membrane protein
ND443_08395	COG3106	COG3106 Predicted ATPase
ND443_08405	COG1983	PspC domain protein
ND443_08415	COG1842	Phage shock protein A
ND443_08420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND443_08435	COG4166	transmembrane transport
ND443_08445	COG4171	peptide transport system, permease
ND443_08450	COG4172	Belongs to the ABC transporter superfamily
ND443_08455	COG4172	Belongs to the ABC transporter superfamily
ND443_08465	COG3104	oligopeptide transport
ND443_08475	COG0484	heat shock protein binding
ND443_08520	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND443_08525	COG3133	Outer membrane lipoprotein
ND443_08530	COG1846	Transcriptional regulator
ND443_08540	COG4989	oxidoreductase activity
ND443_08545	COG3313	Fe-S protein
ND443_08550	COG2194	sulfuric ester hydrolase activity
ND443_08555	COG1309	transcriptional regulator
ND443_08560	COG1902	pentaerythritol trinitrate reductase activity
ND443_08575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND443_08580	COG0791	NLP P60 protein
ND443_08585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND443_08595	COG1609	Transcriptional regulator
ND443_08600	COG0583	DNA-binding transcription factor activity
ND443_08605	COG2814	Major facilitator Superfamily
ND443_08610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND443_08615	COG0307	riboflavin synthase, alpha
ND443_08650	COG1376	ErfK ybiS ycfS ynhG family protein
ND443_08650	COG1388	LysM domain
ND443_08655	COG2166	iron-sulfur cluster assembly
ND443_08665	COG0719	Fe-S assembly protein
ND443_08670	COG0396	ATPase activity
ND443_08675	COG0719	Fe-S assembly protein
ND443_08680	COG0316	Belongs to the HesB IscA family
ND443_08685	COG2050	protein possibly involved in aromatic compounds catabolism
ND443_08690	COG0277	FAD linked oxidase domain protein
ND443_08690	COG0247	lactate metabolic process
ND443_08695	COG0628	permease
ND443_08705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND443_08705	COG0574	Belongs to the PEP-utilizing enzyme family
ND443_08710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND443_08715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND443_08725	COG4771	TonB-dependent receptor
ND443_08730	COG3720	iron ion transport
ND443_08735	COG4558	Periplasmic binding protein
ND443_08740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND443_08745	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND443_08755	COG0095	Lipoate-protein ligase
ND443_08760	COG0791	NLP P60 protein
ND443_08765	COG2076	Multidrug Resistance protein
ND443_08770	COG2076	Multidrug Resistance protein
ND443_08775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND443_08790	COG0463	Glycosyl transferase, family 2
ND443_08795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND443_08805	COG4139	cobalamin transport
ND443_08850	COG2184	nucleotidyltransferase activity
ND443_08865	COG2314	TM2 domain
ND443_08870	COG0776	regulation of translation
ND443_08940	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND443_08945	COG1121	(ABC) transporter
ND443_08950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND443_08955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND443_08960	COG3001	Fructosamine kinase
ND443_08970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND443_08975	COG1988	membrane-bound metal-dependent
ND443_08980	COG1823	symporter activity
ND443_08985	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND443_08995	COG2814	Major facilitator Superfamily
ND443_09005	COG0501	Belongs to the peptidase M48B family
ND443_09010	COG0793	Belongs to the peptidase S41A family
ND443_09020	COG1956	GAF domain-containing protein
ND443_09025	COG2995	paraquat-inducible protein a
ND443_09030	COG3008	intermembrane lipid transfer
ND443_09035	COG3706	GGDEF domain
ND443_09035	COG2203	Gaf domain
ND443_09035	COG4251	negative regulation of phosphorylation
ND443_09035	COG5001	Diguanylate cyclase
ND443_09245	COG3772	lysozyme
ND443_09295	COG1674	ftsk spoiiie
ND443_09295	COG1178	ABC-type Fe3 transport system permease component
ND443_09415	COG1276	copper resistance
ND443_09420	COG2372	response to copper ion
ND443_09425	COG1528	Iron-storage protein
ND443_09440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND443_09445	COG1770	oligopeptidase
ND443_09455	COG3097	Belongs to the UPF0267 family
ND443_09460	COG3141	response to X-ray
ND443_09465	COG0513	Belongs to the DEAD box helicase family
ND443_09485	COG0494	nUDIX hydrolase
ND443_09490	COG1760	l-serine dehydratase
ND443_09495	COG1253	flavin adenine dinucleotide binding
ND443_09500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND443_09500	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND443_09505	COG3715	PTS system
ND443_09510	COG3716	PTS system mannose fructose sorbose family IID component
ND443_09515	COG4811	Protein of unknown function (DUF986)
ND443_09520	COG1971	Probably functions as a manganese efflux pump
ND443_09540	COG1960	acyl-CoA dehydrogenase activity
ND443_09550	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND443_09580	COG2226	methyltransferase
ND443_09585	COG0768	penicillin binding
ND443_09590	COG1496	oxidoreductase activity
ND443_09610	COG1113	amino acid transport
ND443_09645	COG2207	Transcriptional regulator
ND443_09665	COG1132	(ABC) transporter
ND443_09675	COG2203	Gaf domain
ND443_09675	COG3706	GGDEF domain
ND443_09675	COG5001	Diguanylate cyclase
ND443_09675	COG4251	negative regulation of phosphorylation
ND443_09695	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND443_09715	COG1278	Cold shock
ND443_09720	COG1278	Cold shock
ND443_09725	COG1278	Cold shock
ND443_09740	COG1917	Cupin 2, conserved barrel domain protein
ND443_09740	COG2169	Transcriptional regulator
ND443_09745	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND443_09750	COG2723	6-phospho-beta-galactosidase activity
ND443_09755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND443_09760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND443_09765	COG1187	pseudouridine synthase activity
ND443_09775	COG3122	Protein conserved in bacteria
ND443_09780	COG1757	Na H antiporter
ND443_09795	COG2235	arginine
ND443_09810	COG0076	glutamate decarboxylase activity
ND443_09815	COG0531	amino acid
ND443_09850	COG2153	protein acetylation
ND443_09855	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND443_09885	COG0840	transmembrane signaling receptor activity
ND443_09890	COG2801	Transposase and inactivated derivatives
ND443_09910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND443_09915	COG0322	excinuclease ABC activity
ND443_09920	COG2197	response regulator
ND443_09945	COG1113	amino acid transport
ND443_09955	COG0531	amino acid
ND443_09960	COG3710	Transcriptional regulator
ND443_09965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND443_09970	COG0506	proline dehydrogenase activity
ND443_09970	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND443_09970	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND443_09975	COG1126	abc transporter atp-binding protein
ND443_09980	COG0765	amino acid transport
ND443_09985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND443_09990	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND443_10000	COG1191	sigma factor activity
ND443_10040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND443_10045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND443_10060	COG1677	Flagellar hook-basal body complex protein FliE
ND443_10070	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND443_10075	COG1317	bacterial-type flagellum organization
ND443_10080	COG1157	protein secretion by the type III secretion system
ND443_10095	COG1580	Controls the rotational direction of flagella during chemotaxis
ND443_10175	COG1558	bacterial-type flagellum-dependent cell motility
ND443_10180	COG1815	bacterial-type flagellum-dependent cell motility
ND443_10190	COG2747	anti-sigma28 factor FlgM
ND443_10195	COG3418	PFAM FlgN family protein
ND443_10205	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND443_10210	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND443_10215	COG1404	Belongs to the peptidase S8 family
ND443_10215	COG4935	Belongs to the peptidase S8 family
ND443_10220	COG2197	response regulator
ND443_10235	COG3188	usher protein
ND443_10240	COG3121	Chaperone
ND443_10250	COG3539	Fimbrial protein
ND443_10280	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND443_10285	COG0745	RESPONSE REGULATOR receiver
ND443_10295	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND443_10300	COG0840	transmembrane signaling receptor activity
ND443_10305	COG0840	transmembrane signaling receptor activity
ND443_10310	COG0835	chemotaxis
ND443_10315	COG0643	Histidine kinase
ND443_10315	COG2198	Histidine kinase
ND443_10320	COG1360	Flagellar Motor Protein
ND443_10340	COG0589	response to stress
ND443_10345	COG1285	pathogenesis
ND443_10350	COG0840	transmembrane signaling receptor activity
ND443_10370	COG1609	Transcriptional regulator
ND443_10380	COG0604	alcohol dehydrogenase
ND443_10380	COG3321	synthase
ND443_10380	COG1028	Short-chain dehydrogenase reductase Sdr
ND443_10415	COG0582	viral genome integration into host DNA
ND443_10430	COG3423	Transcriptional regulator
ND443_10465	COG3451	type IV secretory pathway VirB4
ND443_10485	COG3736	Type IV secretory pathway, component VirB8
ND443_10500	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ND443_10515	COG4227	nucleotidyltransferase activity
ND443_10575	COG0471	metal ion transport
ND443_10590	COG3051	citrate lyase alpha subunit
ND443_10595	COG2301	Belongs to the HpcH HpaI aldolase family
ND443_10600	COG3052	prosthetic group binding
ND443_10605	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND443_10610	COG3290	protein histidine kinase activity
ND443_10615	COG4565	transcriptional regulatory protein
ND443_10630	COG2271	Major facilitator Superfamily
ND443_10635	COG1840	ABC-type Fe3 transport system, periplasmic component
ND443_10645	COG3842	ATPase activity
ND443_10665	COG1289	transmembrane transporter activity
ND443_10675	COG2925	Exonuclease
ND443_10680	COG0531	amino acid
ND443_10685	COG4771	TonB-dependent receptor
ND443_10695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND443_10705	COG0833	amino acid
ND443_10710	COG0583	DNA-binding transcription factor activity
ND443_10720	COG2855	membrane
ND443_10725	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND443_10730	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND443_10730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND443_10730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND443_10735	COG1105	Belongs to the carbohydrate kinase PfkB family
ND443_10750	COG3005	denitrification pathway
ND443_10755	COG0243	molybdopterin cofactor binding
ND443_10770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND443_10780	COG0246	Mannitol dehydrogenase
ND443_10790	COG0523	cobalamin synthesis protein
ND443_10795	COG0671	phosphoesterase, PA-phosphatase related
ND443_10800	COG0791	NLP P60 protein
ND443_10805	COG2200	EAL domain
ND443_10810	COG4166	transmembrane transport
ND443_10815	COG4174	ABC transporter (Permease)
ND443_10820	COG4239	(ABC) transporter, permease
ND443_10825	COG4172	Belongs to the ABC transporter superfamily
ND443_10835	COG2814	Major facilitator Superfamily
ND443_10840	COG1187	pseudouridine synthase activity
ND443_10845	COG1061	Type III restriction enzyme res subunit
ND443_10860	COG3082	Protein of unknown function (DUF1414)
ND443_10865	COG3083	sulfuric ester hydrolase activity
ND443_10895	COG3299	homolog of phage Mu protein gp47
ND443_10940	COG4386	tail sheath protein
ND443_10980	COG0616	signal peptide processing
ND443_11030	COG3179	chitinase
ND443_11045	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ND443_11075	COG1403	HNH endonuclease
ND443_11090	COG4725	Belongs to the MT-A70-like family
ND443_11095	COG4626	Terminase
ND443_11095	COG1802	Transcriptional regulator
ND443_11140	COG5532	Uncharacterized conserved protein (DUF2303)
ND443_11145	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND443_11195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND443_11200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND443_11220	COG2223	nitrite transmembrane transporter activity
ND443_11225	COG2198	Histidine kinase
ND443_11225	COG0642	Histidine kinase
ND443_11235	COG2205	protein histidine kinase activity
ND443_11235	COG0784	Response regulator, receiver
ND443_11245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND443_11250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND443_11260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND443_11270	COG4574	serine-type endopeptidase inhibitor activity
ND443_11280	COG2246	polysaccharide biosynthetic process
ND443_11295	COG0814	amino acid
ND443_11320	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND443_11325	COG0596	Alpha beta hydrolase
ND443_11330	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND443_11335	COG1169	isochorismate synthase
ND443_11340	COG4575	ribosome binding
ND443_11355	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND443_11360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND443_11370	COG0839	Belongs to the complex I subunit 6 family
ND443_11375	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND443_11380	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND443_11385	COG1034	ATP synthesis coupled electron transport
ND443_11405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND443_11410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND443_11415	COG0583	DNA-binding transcription factor activity
ND443_11420	COG0436	Aminotransferase
ND443_11425	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND443_11430	COG0471	metal ion transport
ND443_11430	COG0490	domain, Protein
ND443_11440	COG3013	Belongs to the UPF0304 family
ND443_11445	COG3092	negative regulation of chromosome organization
ND443_11455	COG0280	phosphate acetyltransferase
ND443_11455	COG0857	belongs to the CobB CobQ family
ND443_11460	COG1609	Transcriptional regulator
ND443_11475	COG3037	sugar-specific permease SgaT UlaA
ND443_11480	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND443_11485	COG0622	Phosphoesterase
ND443_11500	COG0625	glutathione transferase activity
ND443_11505	COG1090	epimerase
ND443_11515	COG4160	amino acid transport
ND443_11520	COG4215	(ABC) transporter
ND443_11535	COG0163	prenyltransferase activity
ND443_11540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND443_11545	COG1286	toxin biosynthetic process
ND443_11550	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND443_11555	COG0285	dihydrofolate synthase activity
ND443_11565	COG0586	Pfam SNARE associated Golgi protein
ND443_11575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND443_11600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND443_11605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND443_11635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND443_11650	COG3101	peptidyl-lysine hydroxylation
ND443_11655	COG0730	response to heat
ND443_11660	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND443_11670	COG2890	protein-(glutamine-N5) methyltransferase activity
ND443_11675	COG2840	Smr protein MutS2
ND443_11680	COG2062	phosphohistidine phosphatase, SixA
ND443_11685	COG1024	Enoyl-CoA hydratase
ND443_11685	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND443_11690	COG0183	Belongs to the thiolase family
ND443_11695	COG3691	Protein conserved in bacteria
ND443_11710	COG3088	subunit of a heme lyase
ND443_11710	COG4235	cytochrome complex assembly
ND443_11715	COG3088	subunit of a heme lyase
ND443_11715	COG4235	cytochrome complex assembly
ND443_11720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND443_11725	COG1138	Cytochrome C-type biogenesis protein
ND443_11730	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND443_11735	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND443_11740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND443_11745	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND443_11765	COG2824	Alkylphosphonate utilization operon protein PhnA
ND443_11770	COG2951	lytic endotransglycosylase activity
ND443_11775	COG1598	PFAM Uncharacterised protein family UPF0150
ND443_11785	COG3038	cytochrome b561
ND443_11790	COG0436	Aminotransferase
ND443_11800	COG3275	phosphorelay sensor kinase activity
ND443_11805	COG3279	Response regulator of the LytR AlgR family
ND443_11810	COG2223	nitrite transmembrane transporter activity
ND443_11815	COG0837	glucose binding
ND443_11835	COG1914	H( )-stimulated, divalent metal cation uptake system
ND443_11840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND443_11900	COG3530	Putative quorum-sensing-regulated virulence factor
ND443_11905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND443_11915	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND443_11925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND443_11940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND443_11950	COG4208	sulfate ABC transporter
ND443_11955	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND443_11960	COG4150	thiosulfate binding
ND443_11970	COG1737	Transcriptional regulator
ND443_11975	COG2731	YhcH YjgK YiaL family protein
ND443_11990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND443_11995	COG2837	iron assimilation
ND443_12005	COG3111	PFAM Bacterial OB fold (BOF) protein
ND443_12065	COG1671	Belongs to the UPF0178 family
ND443_12070	COG0281	malic enzyme
ND443_12070	COG0280	phosphate acetyltransferase
ND443_12075	COG0494	nUDIX hydrolase
ND443_12080	COG3005	denitrification pathway
ND443_12085	COG3043	anaerobic respiration
ND443_12090	COG0243	molybdopterin cofactor binding
ND443_12095	COG3062	negative regulation of establishment of protein localization
ND443_12100	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND443_12100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND443_12105	COG2197	response regulator
ND443_12115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND443_12125	COG1605	Chorismate mutase
ND443_12130	COG1393	Belongs to the ArsC family
ND443_12135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND443_12140	COG1876	peptidase activity
ND443_12150	COG0400	carboxylic ester hydrolase activity
ND443_12170	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND443_12175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND443_12180	COG2716	regulation of RNA biosynthetic process
ND443_12185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND443_12190	COG0628	permease
ND443_12195	COG4783	chaperone-mediated protein folding
ND443_12200	COG1393	Belongs to the ArsC family
ND443_12205	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND443_12210	COG2233	PERMEase
ND443_12215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND443_12220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND443_12225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND443_12230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND443_12240	COG0581	inorganic phosphate transmembrane transporter activity
ND443_12245	COG0573	inorganic phosphate transmembrane transporter activity
ND443_12250	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND443_12265	COG2239	Acts as a magnesium transporter
ND443_12270	COG0443	Heat shock 70 kDa protein
ND443_12280	COG3121	Chaperone
ND443_12300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND443_12310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND443_12315	COG0477	Major facilitator Superfamily
ND443_12320	COG2205	protein histidine kinase activity
ND443_12325	COG0745	RESPONSE REGULATOR receiver
ND443_12330	COG3422	double-strand break repair
ND443_12335	COG0826	peptidase U32
ND443_12340	COG1597	lipid kinase activity
ND443_12355	COG0351	phosphomethylpyrimidine kinase
ND443_12365	COG0519	Catalyzes the synthesis of GMP from XMP
ND443_12365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND443_12370	COG0517	IMP dehydrogenase activity
ND443_12370	COG0516	GMP reductase activity
ND443_12375	COG1570	exodeoxyribonuclease VII activity
ND443_12380	COG1645	bacterial-type flagellum-dependent swarming motility
ND443_12390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND443_12395	COG2976	Protein conserved in bacteria
ND443_12400	COG0124	histidyl-tRNA synthetase
ND443_12420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND443_12435	COG4953	penicillin-binding protein 1C
ND443_12440	COG2373	Large extracellular alpha-helical protein
ND443_12455	COG2975	iron-sulfur cluster assembly
ND443_12460	COG0633	Ferredoxin
ND443_12465	COG0443	Heat shock 70 kDa protein
ND443_12480	COG0822	iron-sulfur transferase activity
ND443_12490	COG1959	2 iron, 2 sulfur cluster binding
ND443_12495	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND443_12505	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND443_12510	COG3683	transport system, periplasmic component
ND443_12515	COG3711	transcriptional antiterminator
ND443_12520	COG2814	Major facilitator Superfamily
ND443_12530	COG1017	nitric oxide dioxygenase activity
ND443_12530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND443_12535	COG2188	Transcriptional regulator
ND443_12545	COG3457	Alanine racemase
ND443_12550	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND443_12565	COG0347	Belongs to the P(II) protein family
ND443_12570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND443_12570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND443_12575	COG2204	response regulator
ND443_12580	COG3170	Tfp pilus assembly protein FimV
ND443_12585	COG2205	protein histidine kinase activity
ND443_12600	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND443_12610	COG0560	Phosphoserine phosphatase
ND443_12615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND443_12615	COG1263	PTS System
ND443_12625	COG1737	Transcriptional regulator
ND443_12630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND443_12640	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND443_12650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND443_12665	COG0481	GTPase activity
ND443_12670	COG3086	response to oxidative stress
ND443_12680	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND443_12690	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND443_12700	COG0513	Belongs to the DEAD box helicase family
ND443_12715	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND443_12725	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND443_12730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND443_12735	COG0497	DNA recombination
ND443_12740	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND443_12750	COG2867	negative regulation of translational initiation
ND443_12755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND443_12765	COG0582	viral genome integration into host DNA
ND443_12795	COG3596	GTP binding
ND443_12800	COG2378	regulation of single-species biofilm formation
ND443_12810	COG2378	regulation of single-species biofilm formation
ND443_12835	COG2003	Belongs to the UPF0758 family
ND443_12890	COG3121	Chaperone
ND443_12895	COG3188	usher protein
ND443_12920	COG0583	DNA-binding transcription factor activity
ND443_12995	COG1069	ribulokinase activity
ND443_13005	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND443_13010	COG1129	ABC transporter
ND443_13030	COG1620	l-lactate permease
ND443_13035	COG1304	FMN binding
ND443_13040	COG0579	oxidoreductase
ND443_13045	COG1278	Cold shock
ND443_13075	COG1780	Probably involved in ribonucleotide reductase function
ND443_13080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND443_13090	COG4175	Glycine betaine
ND443_13095	COG4176	ABC-type proline glycine betaine transport system permease component
ND443_13100	COG2113	Glycine betaine
ND443_13110	COG2814	Major facilitator Superfamily
ND443_13115	COG1846	Transcriptional regulator
ND443_13125	COG1566	PFAM secretion protein HlyD family protein
ND443_13130	COG2814	Major facilitator Superfamily
ND443_13135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND443_13140	COG3118	belongs to the thioredoxin family
ND443_13145	COG3148	PFAM DTW domain containing protein
ND443_13150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND443_13150	COG0045	succinate-CoA ligase (ADP-forming) activity
ND443_13150	COG1042	CoA-binding domain protein
ND443_13155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND443_13160	COG5544	Lipoprotein
ND443_13185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND443_13195	COG2011	ABC-type metal ion transport system permease component
ND443_13200	COG1464	Belongs to the NlpA lipoprotein family
ND443_13210	COG1720	tRNA m6t6A37 methyltransferase activity
ND443_13215	COG0442	prolyl-tRNA aminoacylation
ND443_13220	COG3015	lipoprotein NlpE involved in copper resistance
ND443_13230	COG4681	YaeQ
ND443_13240	COG4568	rho-dependent transcription termination
ND443_13255	COG0346	lactoylglutathione lyase activity
ND443_13270	COG0825	malonyl-CoA metabolic process
ND443_13275	COG0587	DNA-directed DNA polymerase activity
ND443_13280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND443_13300	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND443_13305	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND443_13315	COG0750	zinc metalloprotease
ND443_13320	COG0575	Belongs to the CDS family
ND443_13340	COG0528	UMP kinase activity
ND443_13345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND443_13360	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND443_13365	COG2171	N-acyltransferase activity
ND443_13380	COG0564	pseudouridine synthase activity
ND443_13385	COG3098	single-species biofilm formation
ND443_13400	COG1611	Belongs to the LOG family
ND443_13410	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND443_13415	COG2363	Small membrane protein
ND443_13420	COG0583	DNA-binding transcription factor activity
ND443_13430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND443_13435	COG2166	iron-sulfur cluster assembly
ND443_13440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND443_13445	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND443_13465	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND443_13470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND443_13470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND443_13475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND443_13480	COG1074	ATP-dependent DNA helicase activity
ND443_13485	COG1025	Belongs to the peptidase M16 family
ND443_13490	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND443_13495	COG4967	type IV pilus modification protein PilV
ND443_13520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND443_13525	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND443_13535	COG3066	DNA modification
ND443_13540	COG0861	Integral membrane protein TerC family
ND443_13545	COG0667	Aldo Keto reductase
ND443_13550	COG0477	Major facilitator Superfamily
ND443_13555	COG0318	PFAM AMP-dependent synthetase and ligase
ND443_13555	COG0204	Acyl-transferase
ND443_13560	COG1609	Transcriptional regulator
ND443_13570	COG0583	DNA-binding transcription factor activity
ND443_13575	COG0583	DNA-binding transcription factor activity
ND443_13630	COG2165	general secretion pathway protein
ND443_13640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND443_13670	COG1127	ABC transporter
ND443_13675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND443_13685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND443_13695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND443_13700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND443_13705	COG4974	Belongs to the 'phage' integrase family
ND443_13710	COG0716	FMN binding
ND443_13720	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND443_13730	COG1272	protein, Hemolysin III
ND443_13750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND443_13755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND443_13760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND443_13765	COG0006	proline dipeptidase activity
ND443_13775	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND443_13785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND443_13790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND443_13795	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND443_13810	COG1279	arginine transmembrane transporter activity
ND443_13820	COG0191	fructose-bisphosphate aldolase activity
ND443_13825	COG0126	phosphoglycerate kinase activity
ND443_13830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND443_13835	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND443_13845	COG1166	arginine decarboxylase activity
ND443_13850	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND443_13865	COG0640	Transcriptional regulator
ND443_13870	COG3091	SprT-like family
ND443_13875	COG2356	endonuclease I
ND443_13880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND443_13885	COG0189	ligase activity
ND443_13890	COG1678	Uncharacterized ACR, COG1678
ND443_13895	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND443_13900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND443_13910	COG2805	Type II/IV secretion system protein
ND443_13915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND443_13920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND443_13925	COG0762	integral membrane protein
ND443_13930	COG1872	DUF167
ND443_13935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND443_13940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND443_13955	COG3171	Protein conserved in bacteria
ND443_13965	COG1194	a g-specific adenine glycosylase
ND443_13970	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND443_13975	COG0741	lytic transglycosylase activity
ND443_14020	COG1105	Belongs to the carbohydrate kinase PfkB family
ND443_14025	COG1882	Formate acetyltransferase
ND443_14030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND443_14035	COG0814	amino acid
ND443_14050	COG1028	Short-chain dehydrogenase reductase Sdr
ND443_14055	COG3433	isochorismatase activity
ND443_14055	COG1535	isochorismatase
ND443_14060	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND443_14065	COG1169	isochorismate synthase
ND443_14070	COG4592	Periplasmic binding protein
ND443_14080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND443_14085	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND443_14090	COG1120	ATPase activity
ND443_14100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND443_14105	COG3251	PFAM MbtH domain protein
ND443_14115	COG4774	siderophore transport
ND443_14120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND443_14145	COG4964	Belongs to the GSP D family
ND443_14205	COG0848	biopolymer transport protein
ND443_14210	COG0811	peptide transport
ND443_14215	COG0626	cystathionine gamma-synthase activity
ND443_14220	COG0586	Pfam SNARE associated Golgi protein
ND443_14225	COG2207	Transcriptional regulator
ND443_14230	COG1979	alcohol dehydrogenase
ND443_14235	COG0656	L-ascorbic acid biosynthetic process
ND443_14245	COG2132	Multicopper oxidase
ND443_14260	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND443_14265	COG0583	DNA-binding transcription factor activity
ND443_14270	COG0187	DNA topoisomerase II activity
ND443_14275	COG3150	esterase
ND443_14280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND443_14285	COG3151	Protein conserved in bacteria
ND443_14290	COG0494	nUDIX hydrolase
ND443_14295	COG1538	Outer membrane efflux protein
ND443_14300	COG5463	Belongs to the UPF0441 family
ND443_14305	COG0754	glutathionylspermidine amidase activity
ND443_14310	COG3384	dioxygenase
ND443_14315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND443_14330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND443_14330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND443_14340	COG3025	triphosphatase activity
ND443_14345	COG4991	sh3 domain protein
ND443_14350	COG0617	tRNA 3'-terminal CCA addition
ND443_14355	COG1968	undecaprenyl-diphosphatase activity
ND443_14360	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND443_14365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND443_14370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND443_14375	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND443_14380	COG0358	DNA primase activity
ND443_14410	COG1028	Short-chain dehydrogenase reductase Sdr
ND443_14440	COG0463	Glycosyl transferase, family 2
ND443_14475	COG3210	domain, Protein
ND443_14480	COG2831	hemolysin activation secretion protein
ND443_14485	COG1902	pentaerythritol trinitrate reductase activity
ND443_14485	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND443_14500	COG1451	nucleotide metabolic process
ND443_14505	COG0673	inositol 2-dehydrogenase activity
ND443_14510	COG0861	Integral membrane protein TerC family
ND443_14515	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND443_14525	COG2721	sulfolactate sulfo-lyase activity
ND443_14540	COG2271	Major facilitator Superfamily
ND443_14555	COG0586	Pfam SNARE associated Golgi protein
ND443_14570	COG4575	ribosome binding
ND443_14575	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND443_14585	COG2259	Doxx family
ND443_14590	COG0583	DNA-binding transcription factor activity
ND443_14595	COG1741	Belongs to the pirin family
ND443_14610	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ND443_14625	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND443_14630	COG2823	Periplasmic or secreted lipoprotein
ND443_14635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND443_14640	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND443_14645	COG5002	protein histidine kinase activity
ND443_14645	COG2198	Histidine kinase
ND443_14645	COG0784	Response regulator, receiver
ND443_14650	COG1242	4 iron, 4 sulfur cluster binding
ND443_14655	COG0070	glutamate synthase
ND443_14655	COG0069	glutamate synthase activity
ND443_14655	COG0067	glutamate synthase
ND443_14660	COG0493	'glutamate synthase
ND443_14670	COG2969	positive regulation of protein catabolic process
ND443_14675	COG0625	glutathione transferase activity
ND443_14680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND443_14685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND443_14690	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND443_14695	COG3105	Protein conserved in bacteria
ND443_14700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND443_14710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND443_14715	COG5007	Belongs to the BolA IbaG family
ND443_14720	COG3113	response to antibiotic
ND443_14725	COG2854	intermembrane phospholipid transfer
ND443_14730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND443_14735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND443_14740	COG1127	ABC transporter
ND443_14745	COG0530	calcium, potassium:sodium antiporter activity
ND443_14750	COG0517	IMP dehydrogenase activity
ND443_14750	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND443_14755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND443_14760	COG3117	lipopolysaccharide transmembrane transporter activity
ND443_14765	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND443_14770	COG1137	ATPase activity
ND443_14775	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND443_14795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND443_14800	COG0540	Belongs to the ATCase OTCase family
ND443_14805	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND443_14815	COG0366	Alpha amylase catalytic
ND443_14820	COG1263	PTS System
ND443_14820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND443_14830	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND443_14840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND443_14845	COG3783	Cytochrome b(562)
ND443_14850	COG0312	modulator of DNA gyrase
ND443_14855	COG3028	Belongs to the UPF0307 family
ND443_14860	COG2732	(Barnase) inhibitor
ND443_14865	COG4290	ribonuclease
ND443_14875	COG1289	transmembrane transporter activity
ND443_14880	COG1566	PFAM secretion protein HlyD family protein
ND443_14890	COG0583	DNA-binding transcription factor activity
ND443_14895	COG0312	modulator of DNA gyrase
ND443_14900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND443_14905	COG3164	Protein of unknown function
ND443_14915	COG0424	maF-like protein
ND443_14920	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND443_14925	COG1792	Involved in formation and maintenance of cell shape
ND443_14930	COG1077	Cell shape determining protein MreB Mrl
ND443_14935	COG2200	EAL domain
ND443_14935	COG2199	diguanylate cyclase activity
ND443_14940	COG0604	alcohol dehydrogenase
ND443_14945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND443_14950	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND443_14960	COG0511	ligase activity, forming carbon-carbon bonds
ND443_14965	COG0439	Biotin carboxylase
ND443_14970	COG3924	membrane
ND443_14975	COG4145	pantothenate transmembrane transporter activity
ND443_14980	COG2264	protein methyltransferase activity
ND443_14985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND443_14990	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND443_15000	COG1560	Kdo2-lipid A biosynthetic process
ND443_15010	COG1346	cytolysis
ND443_15015	COG1380	Effector of murein hydrolase LrgA
ND443_15020	COG0583	DNA-binding transcription factor activity
ND443_15025	COG0025	NhaP-type Na H and K H
ND443_15030	COG2252	PERMEase
ND443_15045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND443_15050	COG2315	Protein conserved in bacteria
ND443_15055	COG1448	Aminotransferase
ND443_15080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND443_15085	COG0735	belongs to the Fur family
ND443_15090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND443_15095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND443_15100	COG2937	Belongs to the GPAT DAPAT family
ND443_15120	COG4580	involved in the transport of maltose and maltodextrins
ND443_15135	COG2182	Extracellular solute-binding protein
ND443_15140	COG1175	transmembrane transport
ND443_15145	COG3833	ABC-type maltose transport systems, permease component
ND443_15150	COG3223	Belongs to the PsiE family
ND443_15160	COG0527	aspartate kinase activity
ND443_15175	COG3328	transposase activity
ND443_15200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ND443_15280	COG0583	DNA-binding transcription factor activity
ND443_15320	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND443_15360	COG0138	bifunctional purine biosynthesis protein purh
ND443_15365	COG0151	Belongs to the GarS family
ND443_15385	COG1515	deoxyribonuclease V activity
ND443_15390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND443_15395	COG2816	NAD+ diphosphatase activity
ND443_15400	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND443_15415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND443_15420	COG2104	thiamine diphosphate biosynthetic process
ND443_15425	COG2022	thiamine diphosphate biosynthetic process
ND443_15435	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND443_15440	COG0085	RNA polymerase activity
ND443_15445	COG0222	ribosome binding
ND443_15450	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND443_15460	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND443_15465	COG0250	Participates in transcription elongation, termination and antitermination
ND443_15510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND443_15535	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND443_15540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND443_15545	COG1739	Uncharacterized protein family UPF0029
ND443_15555	COG1024	Enoyl-CoA hydratase
ND443_15555	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND443_15565	COG0543	2 iron, 2 sulfur cluster binding
ND443_15580	COG0250	Participates in transcription elongation, termination and antitermination
ND443_15595	COG0805	protein transport
ND443_15600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND443_15605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND443_15610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND443_15615	COG3165	ubiquinone biosynthetic process from chorismate
ND443_15620	COG2226	methyltransferase
ND443_15625	COG1322	Protein conserved in bacteria
ND443_15630	COG0586	Pfam SNARE associated Golgi protein
ND443_15635	COG1966	Carbon starvation protein
ND443_15650	COG0412	Dienelactone hydrolase
ND443_15655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND443_15660	COG0583	DNA-binding transcription factor activity
ND443_15665	COG0697	spore germination
ND443_15675	COG0584	glycerophosphoryl diester phosphodiesterase
ND443_15685	COG0395	ABC-type sugar transport system, permease component
ND443_15690	COG1175	transmembrane transport
ND443_15695	COG1653	transport
ND443_15730	COG0410	ABC transporter
ND443_15740	COG4177	L-phenylalanine transmembrane transporter activity
ND443_15760	COG1929	Belongs to the glycerate kinase type-1 family
ND443_15765	COG2610	gluconate transmembrane transporter activity
ND443_15770	COG3835	regulator
ND443_15780	COG2177	Part of the ABC transporter FtsEX involved in
ND443_15785	COG2884	Cell division ATP-binding protein ftsE
ND443_15790	COG0552	protein localization to endoplasmic reticulum
ND443_15790	COG0552	protein localization to endoplasmic reticulum
ND443_15795	COG0742	ribosomal rna small subunit methyltransferase
ND443_15800	COG3776	membrane
ND443_15815	COG3714	YhhN family
ND443_15830	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND443_15840	COG0247	lactate metabolic process
ND443_15850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND443_15860	COG2271	Major facilitator Superfamily
ND443_15865	COG0584	glycerophosphoryl diester phosphodiesterase
ND443_15870	COG0561	phosphatase activity
ND443_15875	COG2267	carboxylic ester hydrolase activity
ND443_15880	COG1280	lysine exporter protein (LysE YggA)
ND443_15885	COG0514	ATP-dependent DNA helicase (RecQ)
ND443_15890	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND443_15895	COG2050	protein possibly involved in aromatic compounds catabolism
ND443_15915	COG5564	TIM-barrel signal transduction protein
ND443_15920	COG5441	Belongs to the UPF0261 family
ND443_15930	COG0210	DNA helicase
ND443_15935	COG1011	Hydrolase
ND443_15940	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND443_15945	COG3159	Protein conserved in bacteria
ND443_15950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND443_15955	COG5567	small periplasmic lipoprotein
ND443_15965	COG3072	Adenylate cyclase
ND443_15970	COG0181	hydroxymethylbilane synthase activity
ND443_15975	COG1587	Uroporphyrinogen-III synthase
ND443_15980	COG2959	enzyme of heme biosynthesis
ND443_15985	COG3071	HemY protein
ND443_16035	COG2244	polysaccharide biosynthetic process
ND443_16040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND443_16045	COG0456	acetyltransferase
ND443_16050	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND443_16055	COG1088	dTDP-glucose 4,6-dehydratase activity
ND443_16060	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND443_16065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND443_16070	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND443_16075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND443_16080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND443_16085	COG3118	belongs to the thioredoxin family
ND443_16095	COG0248	Ppx GppA phosphatase
ND443_16105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND443_16120	COG3397	chitin binding
ND443_16130	COG0129	dihydroxy-acid dehydratase activity
ND443_16140	COG3978	acetolactate synthase activity
ND443_16160	COG3085	chromosome segregation
ND443_16165	COG0583	DNA-binding transcription factor activity
ND443_16240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND443_16250	COG0678	peroxiredoxin activity
ND443_16250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND443_16255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND443_16290	COG1629	transport
ND443_16295	COG0165	Argininosuccinate lyase
ND443_16300	COG0137	argininosuccinate synthase activity
ND443_16305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND443_16350	COG0527	aspartate kinase activity
ND443_16350	COG0460	homoserine dehydrogenase
ND443_16355	COG0626	cystathionine gamma-synthase activity
ND443_16360	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND443_16370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND443_16375	COG1609	Transcriptional regulator
ND443_16380	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND443_16385	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND443_16390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND443_16395	COG1575	Belongs to the MenA family. Type 1 subfamily
ND443_16400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND443_16405	COG3074	FtsZ-dependent cytokinesis
ND443_16410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND443_16415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND443_16420	COG1494	fructose-1,6-bisphosphatase
ND443_16425	COG2814	Major facilitator Superfamily
ND443_16435	COG3152	Membrane
ND443_16450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND443_16460	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND443_16465	COG3678	ATP-independent chaperone mediated protein folding
ND443_16470	COG0745	RESPONSE REGULATOR receiver
ND443_16475	COG2205	protein histidine kinase activity
ND443_16480	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND443_16485	COG1045	serine acetyltransferase
ND443_16490	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND443_16495	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND443_16500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND443_16505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND443_16510	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND443_16515	COG4942	peptidase
ND443_16520	COG2861	carbohydrate metabolic process
ND443_16535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND443_16540	COG0859	PFAM glycosyl transferase family 9
ND443_16545	COG0859	PFAM glycosyl transferase family 9
ND443_16550	COG1519	Transferase
ND443_16570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND443_16575	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND443_16580	COG2003	Belongs to the UPF0758 family
ND443_16585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND443_16590	COG0756	dUTP diphosphatase activity
ND443_16595	COG1309	transcriptional regulator
ND443_16600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND443_16605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND443_16610	COG1561	YicC-like family, N-terminal region
ND443_16625	COG5001	Diguanylate cyclase
ND443_16630	COG1024	Enoyl-CoA hydratase
ND443_16635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND443_16645	COG2860	membrane
ND443_16650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND443_16660	COG1758	RNA polymerase activity
ND443_16665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND443_16670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND443_16675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND443_16680	COG0786	glutamate:sodium symporter activity
ND443_16685	COG2233	PERMEase
ND443_16690	COG2982	Protein involved in outer membrane biogenesis
ND443_16695	COG0456	acetyltransferase
ND443_16710	COG1011	Hydrolase
ND443_16725	COG3852	Histidine kinase
ND443_16735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND443_16745	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND443_16750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND443_16750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND443_16755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND443_16760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND443_16765	COG3084	Protein conserved in bacteria
ND443_16775	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND443_16800	COG2186	Transcriptional regulator
ND443_16805	COG1609	Transcriptional regulator
ND443_16810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND443_16820	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND443_16825	COG1129	ABC transporter
ND443_16830	COG1869	D-ribose catabolic process
ND443_16835	COG3158	transport of potassium into the cell
ND443_16840	COG0714	Associated with various cellular activities
ND443_16845	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND443_16855	COG2502	aspartate--ammonia ligase
ND443_16860	COG1522	sequence-specific DNA binding
ND443_16865	COG0716	FMN binding
ND443_16870	COG0445	tRNA wobble uridine modification
ND443_16875	COG0357	Ribosomal RNA small subunit methyltransferase G
ND443_16880	COG3312	ion transport
ND443_16885	COG0356	it plays a direct role in the translocation of protons across the membrane
ND443_16895	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND443_16905	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND443_16910	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND443_16920	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND443_16935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND443_16940	COG0573	inorganic phosphate transmembrane transporter activity
ND443_16945	COG0581	inorganic phosphate transmembrane transporter activity
ND443_16955	COG0704	Plays a role in the regulation of phosphate uptake
ND443_16960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND443_16965	COG0765	amino acid transport
ND443_16970	COG0765	amino acid transport
ND443_16975	COG2252	PERMEase
ND443_16980	COG0840	transmembrane signaling receptor activity
ND443_16990	COG3121	Chaperone
ND443_17005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND443_17010	COG0706	membrane insertase activity
ND443_17020	COG0594	ribonuclease P activity
ND443_17025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ND443_17050	COG1192	Involved in chromosome partitioning
ND443_17120	COG2944	sequence-specific DNA binding
ND443_17280	COG0741	lytic transglycosylase activity
ND443_17295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND443_17400	COG1454	alcohol dehydrogenase