locus-tag	class	description
ND446_00010	COG0592	DNA-directed DNA polymerase activity
ND446_00020	COG0187	DNA topoisomerase II activity
ND446_00025	COG0561	phosphatase activity
ND446_00030	COG0823	Involved in the tonB-independent uptake of proteins
ND446_00035	COG5645	(Lipo)protein
ND446_00050	COG0569	domain protein
ND446_00050	COG2985	domain, Protein
ND446_00055	COG3977	Valine--pyruvate aminotransferase
ND446_00060	COG2885	chlorophyll binding
ND446_00085	COG2818	Glycosylase
ND446_00140	COG2213	PTS system mannitol-specific
ND446_00140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND446_00150	COG3722	fumarate hydratase activity
ND446_00160	COG2258	MOSC domain
ND446_00165	COG0840	transmembrane signaling receptor activity
ND446_00170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND446_00185	COG0437	4 iron, 4 sulfur cluster binding
ND446_00190	COG2864	formate dehydrogenase
ND446_00200	COG1921	L-seryl-tRNASec selenium transferase activity
ND446_00205	COG3276	selenocysteine insertion sequence binding
ND446_00210	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND446_00220	COG3274	enterobacterial common antigen metabolic process
ND446_00230	COG0582	viral genome integration into host DNA
ND446_00265	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND446_00270	COG2986	histidine ammonia-lyase
ND446_00290	COG2194	sulfuric ester hydrolase activity
ND446_00295	COG2197	response regulator
ND446_00300	COG3851	Histidine kinase
ND446_00305	COG2271	Major facilitator Superfamily
ND446_00315	COG0747	negative chemotaxis
ND446_00320	COG0601	transmembrane transport
ND446_00325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND446_00330	COG0444	Belongs to the ABC transporter superfamily
ND446_00335	COG4608	Belongs to the ABC transporter superfamily
ND446_00340	COG2194	sulfuric ester hydrolase activity
ND446_00365	COG1215	transferase activity, transferring glycosyl groups
ND446_00370	COG1215	transferase activity, transferring glycosyl groups
ND446_00375	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND446_00380	COG0457	Tetratricopeptide repeat
ND446_00380	COG3118	belongs to the thioredoxin family
ND446_00385	COG2200	EAL domain
ND446_00385	COG2199	diguanylate cyclase activity
ND446_00390	COG1301	dicarboxylic acid transport
ND446_00395	COG0612	Peptidase, M16
ND446_00400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND446_00405	COG1942	4-Oxalocrotonate Tautomerase
ND446_00410	COG2200	EAL domain
ND446_00420	COG1295	ribonuclease BN
ND446_00430	COG1301	dicarboxylic acid transport
ND446_00435	COG0626	cystathionine gamma-synthase activity
ND446_00445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND446_00450	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND446_00455	COG0339	signal peptide processing
ND446_00460	COG0742	ribosomal rna small subunit methyltransferase
ND446_00470	COG0589	response to stress
ND446_00480	COG0306	phosphate transporter
ND446_00485	COG2081	HI0933 family
ND446_00495	COG1247	-acetyltransferase
ND446_00500	COG1741	Belongs to the pirin family
ND446_00505	COG1609	Transcriptional regulator
ND446_00510	COG2610	gluconate transmembrane transporter activity
ND446_00515	COG3265	gluconokinase activity
ND446_00520	COG2095	MarC family integral membrane protein
ND446_00525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND446_00530	COG3275	phosphorelay sensor kinase activity
ND446_00535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND446_00540	COG1523	belongs to the glycosyl hydrolase 13 family
ND446_00545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND446_00550	COG0297	glycogen (starch) synthase activity
ND446_00555	COG0058	SHG alpha-glucan phosphorylase activity
ND446_00560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND446_00565	COG1349	DNA-binding transcription factor activity
ND446_00570	COG0705	Rhomboid family
ND446_00580	COG2909	trisaccharide binding
ND446_00585	COG0058	SHG alpha-glucan phosphorylase activity
ND446_00590	COG1640	4-alpha-glucanotransferase
ND446_00600	COG1040	competence protein
ND446_00605	COG0596	Alpha beta hydrolase
ND446_00625	COG1918	ferrous iron import across plasma membrane
ND446_00630	COG2183	response to ionizing radiation
ND446_00655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND446_00670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND446_00680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND446_00685	COG1011	Hydrolase
ND446_00695	COG0494	nUDIX hydrolase
ND446_00700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND446_00725	COG4796	Type ii and iii secretion system protein
ND446_00730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND446_00750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND446_00760	COG0180	Tryptophanyl-tRNA synthetase
ND446_00780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND446_00785	COG0402	S-adenosylhomocysteine deaminase activity
ND446_00790	COG0738	Major facilitator superfamily
ND446_00805	COG1609	Transcriptional regulator
ND446_00810	COG1486	melibiose metabolic process
ND446_00815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND446_00830	COG1289	transmembrane transporter activity
ND446_00835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND446_00840	COG1765	OsmC-like protein
ND446_00865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND446_00870	COG3954	Phosphoribulokinase
ND446_00880	COG0429	hydrolase of the alpha beta-hydrolase fold
ND446_00890	COG0859	PFAM glycosyl transferase family 9
ND446_00895	COG1216	Glycosyl transferase, family 2
ND446_00900	COG0488	(ABC) transporter
ND446_00905	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND446_00915	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND446_00920	COG1047	Peptidyl-prolyl cis-trans
ND446_00930	COG0545	Peptidyl-prolyl cis-trans isomerase
ND446_00935	COG2964	Protein conserved in bacteria
ND446_00945	COG2923	Belongs to the DsrF TusC family
ND446_00950	COG2168	tRNA wobble position uridine thiolation
ND446_00955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND446_00960	COG0049	tRNA binding
ND446_00970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND446_00985	COG0051	transcription antitermination factor activity, RNA binding
ND446_00990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND446_01000	COG0089	rRNA binding
ND446_01005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND446_01010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND446_01015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND446_01025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND446_01030	COG0255	Belongs to the universal ribosomal protein uL29 family
ND446_01035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND446_01040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND446_01050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND446_01075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND446_01080	COG1841	ribosomal large subunit assembly
ND446_01085	COG0200	Binds to the 23S rRNA
ND446_01090	COG0201	protein transport
ND446_01095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND446_01100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND446_01110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND446_01120	COG0203	ribosomal protein L17
ND446_01125	COG0789	Transcriptional regulator
ND446_01130	COG3036	rescue of stalled ribosome
ND446_01135	COG1970	mechanosensitive ion channel activity
ND446_01145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND446_01145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND446_01150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND446_01155	COG0242	peptide deformylase activity
ND446_01160	COG0758	DNA mediated transformation
ND446_01165	COG2922	Belongs to the Smg family
ND446_01170	COG0551	DNA topoisomerase type I activity
ND446_01175	COG0009	L-threonylcarbamoyladenylate synthase
ND446_01185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND446_01210	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND446_01255	COG0250	Participates in transcription elongation, termination and antitermination
ND446_01260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND446_01270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND446_01275	COG0222	ribosome binding
ND446_01280	COG0085	RNA polymerase activity
ND446_01285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND446_01295	COG2022	thiamine diphosphate biosynthetic process
ND446_01300	COG2104	thiamine diphosphate biosynthetic process
ND446_01305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND446_01320	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND446_01325	COG2816	NAD+ diphosphatase activity
ND446_01330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND446_01335	COG1515	deoxyribonuclease V activity
ND446_01355	COG0151	Belongs to the GarS family
ND446_01360	COG0138	bifunctional purine biosynthesis protein purh
ND446_01405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND446_01440	COG0583	DNA-binding transcription factor activity
ND446_01520	COG1222	aaa ATPase
ND446_01550	COG0527	aspartate kinase activity
ND446_01560	COG3223	Belongs to the PsiE family
ND446_01565	COG3833	ABC-type maltose transport systems, permease component
ND446_01570	COG1175	transmembrane transport
ND446_01575	COG2182	Extracellular solute-binding protein
ND446_01590	COG4580	involved in the transport of maltose and maltodextrins
ND446_01610	COG2937	Belongs to the GPAT DAPAT family
ND446_01615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND446_01620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND446_01625	COG0735	belongs to the Fur family
ND446_01630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND446_01640	COG0604	alcohol dehydrogenase
ND446_01655	COG1448	Aminotransferase
ND446_01660	COG2315	Protein conserved in bacteria
ND446_01665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND446_01680	COG2252	PERMEase
ND446_01685	COG0025	NhaP-type Na H and K H
ND446_01690	COG0583	DNA-binding transcription factor activity
ND446_01695	COG1380	Effector of murein hydrolase LrgA
ND446_01700	COG1346	cytolysis
ND446_01710	COG1560	Kdo2-lipid A biosynthetic process
ND446_01720	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND446_01725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND446_01730	COG2264	protein methyltransferase activity
ND446_01735	COG4145	pantothenate transmembrane transporter activity
ND446_01740	COG3924	membrane
ND446_01745	COG0439	Biotin carboxylase
ND446_01750	COG0511	ligase activity, forming carbon-carbon bonds
ND446_01760	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND446_01765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND446_01770	COG0604	alcohol dehydrogenase
ND446_01775	COG2200	EAL domain
ND446_01775	COG2199	diguanylate cyclase activity
ND446_01780	COG1077	Cell shape determining protein MreB Mrl
ND446_01785	COG1792	Involved in formation and maintenance of cell shape
ND446_01790	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND446_01795	COG0424	maF-like protein
ND446_01805	COG3164	Protein of unknown function
ND446_01810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND446_01815	COG0312	modulator of DNA gyrase
ND446_01820	COG0583	DNA-binding transcription factor activity
ND446_01830	COG1566	PFAM secretion protein HlyD family protein
ND446_01835	COG1289	transmembrane transporter activity
ND446_01845	COG4290	ribonuclease
ND446_01850	COG2732	(Barnase) inhibitor
ND446_01855	COG3028	Belongs to the UPF0307 family
ND446_01860	COG0312	modulator of DNA gyrase
ND446_01865	COG3783	Cytochrome b(562)
ND446_01870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND446_01880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND446_01890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND446_01890	COG1263	PTS System
ND446_01895	COG0366	Alpha amylase catalytic
ND446_01905	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND446_01910	COG0540	Belongs to the ATCase OTCase family
ND446_01915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND446_01935	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND446_01940	COG1137	ATPase activity
ND446_01945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND446_01950	COG3117	lipopolysaccharide transmembrane transporter activity
ND446_01955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND446_01960	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND446_01960	COG0517	IMP dehydrogenase activity
ND446_01965	COG0530	calcium, potassium:sodium antiporter activity
ND446_01970	COG1127	ABC transporter
ND446_01975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND446_01980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND446_01985	COG2854	intermembrane phospholipid transfer
ND446_01990	COG3113	response to antibiotic
ND446_01995	COG5007	Belongs to the BolA IbaG family
ND446_02000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND446_02010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND446_02015	COG3105	Protein conserved in bacteria
ND446_02020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND446_02025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND446_02030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND446_02035	COG0625	glutathione transferase activity
ND446_02040	COG2969	positive regulation of protein catabolic process
ND446_02050	COG0493	'glutamate synthase
ND446_02055	COG0070	glutamate synthase
ND446_02055	COG0069	glutamate synthase activity
ND446_02055	COG0067	glutamate synthase
ND446_02060	COG1242	4 iron, 4 sulfur cluster binding
ND446_02070	COG0784	Response regulator, receiver
ND446_02070	COG2198	Histidine kinase
ND446_02070	COG5002	protein histidine kinase activity
ND446_02075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND446_02080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND446_02085	COG2823	Periplasmic or secreted lipoprotein
ND446_02090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND446_02105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ND446_02120	COG1741	Belongs to the pirin family
ND446_02125	COG0583	DNA-binding transcription factor activity
ND446_02130	COG2259	Doxx family
ND446_02140	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND446_02145	COG4575	ribosome binding
ND446_02160	COG0586	Pfam SNARE associated Golgi protein
ND446_02175	COG2271	Major facilitator Superfamily
ND446_02190	COG2721	sulfolactate sulfo-lyase activity
ND446_02200	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND446_02205	COG0861	Integral membrane protein TerC family
ND446_02210	COG0673	inositol 2-dehydrogenase activity
ND446_02215	COG1451	nucleotide metabolic process
ND446_02230	COG1902	pentaerythritol trinitrate reductase activity
ND446_02230	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND446_02235	COG2831	hemolysin activation secretion protein
ND446_02240	COG3210	domain, Protein
ND446_02270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND446_02285	COG1028	Short-chain dehydrogenase reductase Sdr
ND446_02340	COG4983	Phage plasmid primase, P4 family domain protein
ND446_02365	COG3596	GTP binding
ND446_02375	COG2378	regulation of single-species biofilm formation
ND446_02400	COG2003	Belongs to the UPF0758 family
ND446_02430	COG4974	Belongs to the 'phage' integrase family
ND446_02490	COG4695	Portal protein
ND446_02590	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ND446_02625	COG0358	DNA primase activity
ND446_02630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND446_02635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND446_02640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND446_02645	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND446_02650	COG1968	undecaprenyl-diphosphatase activity
ND446_02655	COG0617	tRNA 3'-terminal CCA addition
ND446_02660	COG4991	sh3 domain protein
ND446_02665	COG3025	triphosphatase activity
ND446_02675	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND446_02675	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND446_02690	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND446_02695	COG3384	dioxygenase
ND446_02700	COG0754	glutathionylspermidine amidase activity
ND446_02705	COG5463	Belongs to the UPF0441 family
ND446_02710	COG1538	Outer membrane efflux protein
ND446_02715	COG0494	nUDIX hydrolase
ND446_02720	COG3151	Protein conserved in bacteria
ND446_02725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND446_02730	COG3150	esterase
ND446_02735	COG0187	DNA topoisomerase II activity
ND446_02740	COG0583	DNA-binding transcription factor activity
ND446_02745	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND446_02750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ND446_02760	COG2132	Multicopper oxidase
ND446_02770	COG0656	L-ascorbic acid biosynthetic process
ND446_02775	COG1979	alcohol dehydrogenase
ND446_02780	COG2207	Transcriptional regulator
ND446_02785	COG0586	Pfam SNARE associated Golgi protein
ND446_02790	COG0626	cystathionine gamma-synthase activity
ND446_02795	COG0811	peptide transport
ND446_02800	COG0848	biopolymer transport protein
ND446_02845	COG4964	Belongs to the GSP D family
ND446_02870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND446_02875	COG4774	siderophore transport
ND446_02885	COG3251	PFAM MbtH domain protein
ND446_02890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND446_02900	COG1120	ATPase activity
ND446_02905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND446_02910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND446_02920	COG4592	Periplasmic binding protein
ND446_02925	COG1169	isochorismate synthase
ND446_02930	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND446_02935	COG3433	isochorismatase activity
ND446_02935	COG1535	isochorismatase
ND446_02940	COG1028	Short-chain dehydrogenase reductase Sdr
ND446_02955	COG0814	amino acid
ND446_02960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND446_02965	COG1882	Formate acetyltransferase
ND446_02970	COG1105	Belongs to the carbohydrate kinase PfkB family
ND446_02980	COG1349	DNA-binding transcription factor activity
ND446_02985	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND446_02990	COG1028	Short-chain dehydrogenase reductase Sdr
ND446_02995	COG3731	PTS system glucitol sorbitol-specific IIA component
ND446_03000	COG3732	PTS system glucitol sorbitol-specific
ND446_03005	COG3730	PTS system glucitol sorbitol-specific
ND446_03020	COG0583	DNA-binding transcription factor activity
ND446_03105	COG0741	lytic transglycosylase activity
ND446_03110	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND446_03115	COG1194	a g-specific adenine glycosylase
ND446_03125	COG3171	Protein conserved in bacteria
ND446_03140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND446_03145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND446_03150	COG1872	DUF167
ND446_03155	COG0762	integral membrane protein
ND446_03160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND446_03165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND446_03170	COG2805	Type II/IV secretion system protein
ND446_03180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND446_03185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND446_03190	COG1678	Uncharacterized ACR, COG1678
ND446_03195	COG0189	ligase activity
ND446_03200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND446_03205	COG2356	endonuclease I
ND446_03210	COG3091	SprT-like family
ND446_03215	COG0640	Transcriptional regulator
ND446_03230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND446_03235	COG1166	arginine decarboxylase activity
ND446_03245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND446_03250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND446_03255	COG0126	phosphoglycerate kinase activity
ND446_03260	COG0191	fructose-bisphosphate aldolase activity
ND446_03270	COG1279	arginine transmembrane transporter activity
ND446_03285	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND446_03290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND446_03295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND446_03305	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND446_03315	COG0006	proline dipeptidase activity
ND446_03320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND446_03325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND446_03330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND446_03350	COG1272	protein, Hemolysin III
ND446_03360	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND446_03370	COG0716	FMN binding
ND446_03375	COG4974	Belongs to the 'phage' integrase family
ND446_03380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND446_03385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND446_03395	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND446_03405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND446_03410	COG1127	ABC transporter
ND446_03440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND446_03450	COG2165	general secretion pathway protein
ND446_03505	COG0583	DNA-binding transcription factor activity
ND446_03510	COG0583	DNA-binding transcription factor activity
ND446_03520	COG1609	Transcriptional regulator
ND446_03525	COG0318	PFAM AMP-dependent synthetase and ligase
ND446_03525	COG0204	Acyl-transferase
ND446_03530	COG0477	Major facilitator Superfamily
ND446_03535	COG0667	Aldo Keto reductase
ND446_03540	COG0861	Integral membrane protein TerC family
ND446_03545	COG3066	DNA modification
ND446_03555	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND446_03560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND446_03585	COG4967	type IV pilus modification protein PilV
ND446_03590	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND446_03595	COG1025	Belongs to the peptidase M16 family
ND446_03600	COG1074	ATP-dependent DNA helicase activity
ND446_03605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND446_03610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND446_03610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND446_03615	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND446_03635	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND446_03640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND446_03645	COG2166	iron-sulfur cluster assembly
ND446_03650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND446_03660	COG0583	DNA-binding transcription factor activity
ND446_03665	COG2363	Small membrane protein
ND446_03670	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND446_03680	COG1611	Belongs to the LOG family
ND446_03695	COG3098	single-species biofilm formation
ND446_03700	COG0564	pseudouridine synthase activity
ND446_03715	COG2171	N-acyltransferase activity
ND446_03720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND446_03735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND446_03740	COG0528	UMP kinase activity
ND446_03760	COG0575	Belongs to the CDS family
ND446_03765	COG0750	zinc metalloprotease
ND446_03775	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND446_03780	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND446_03800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND446_03805	COG0587	DNA-directed DNA polymerase activity
ND446_03810	COG0825	malonyl-CoA metabolic process
ND446_03825	COG0346	lactoylglutathione lyase activity
ND446_03840	COG4568	rho-dependent transcription termination
ND446_03850	COG4681	YaeQ
ND446_03860	COG3015	lipoprotein NlpE involved in copper resistance
ND446_03865	COG0442	prolyl-tRNA aminoacylation
ND446_03870	COG1720	tRNA m6t6A37 methyltransferase activity
ND446_03880	COG1464	Belongs to the NlpA lipoprotein family
ND446_03885	COG2011	ABC-type metal ion transport system permease component
ND446_03895	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND446_03920	COG5544	Lipoprotein
ND446_03925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND446_03930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND446_03930	COG1042	CoA-binding domain protein
ND446_03930	COG0045	succinate-CoA ligase (ADP-forming) activity
ND446_03935	COG3148	PFAM DTW domain containing protein
ND446_03940	COG3118	belongs to the thioredoxin family
ND446_03945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND446_03950	COG2814	Major facilitator Superfamily
ND446_03955	COG1566	PFAM secretion protein HlyD family protein
ND446_03965	COG1846	Transcriptional regulator
ND446_03970	COG2814	Major facilitator Superfamily
ND446_03980	COG2113	Glycine betaine
ND446_03985	COG4176	ABC-type proline glycine betaine transport system permease component
ND446_03990	COG4175	Glycine betaine
ND446_04005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND446_04010	COG1780	Probably involved in ribonucleotide reductase function
ND446_04040	COG1278	Cold shock
ND446_04045	COG0579	oxidoreductase
ND446_04050	COG1304	FMN binding
ND446_04055	COG1620	l-lactate permease
ND446_04075	COG1129	ABC transporter
ND446_04080	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND446_04090	COG1069	ribulokinase activity
ND446_04220	COG0582	viral genome integration into host DNA
ND446_04230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND446_04235	COG2867	negative regulation of translational initiation
ND446_04245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND446_04250	COG0497	DNA recombination
ND446_04255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND446_04260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND446_04270	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND446_04285	COG0513	Belongs to the DEAD box helicase family
ND446_04295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND446_04305	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND446_04315	COG3086	response to oxidative stress
ND446_04320	COG0481	GTPase activity
ND446_04335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND446_04345	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND446_04355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND446_04360	COG1737	Transcriptional regulator
ND446_04370	COG1263	PTS System
ND446_04370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND446_04375	COG0560	Phosphoserine phosphatase
ND446_04385	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND446_04400	COG2205	protein histidine kinase activity
ND446_04405	COG3170	Tfp pilus assembly protein FimV
ND446_04410	COG2204	response regulator
ND446_04415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND446_04415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND446_04420	COG0347	Belongs to the P(II) protein family
ND446_04435	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND446_04440	COG3457	Alanine racemase
ND446_04450	COG2188	Transcriptional regulator
ND446_04455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND446_04455	COG1017	nitric oxide dioxygenase activity
ND446_04465	COG2814	Major facilitator Superfamily
ND446_04470	COG3711	transcriptional antiterminator
ND446_04475	COG3683	transport system, periplasmic component
ND446_04480	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND446_04490	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND446_04495	COG1959	2 iron, 2 sulfur cluster binding
ND446_04505	COG0822	iron-sulfur transferase activity
ND446_04520	COG0443	Heat shock 70 kDa protein
ND446_04525	COG0633	Ferredoxin
ND446_04530	COG2975	iron-sulfur cluster assembly
ND446_04545	COG2373	Large extracellular alpha-helical protein
ND446_04550	COG4953	penicillin-binding protein 1C
ND446_04565	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND446_04585	COG0124	histidyl-tRNA synthetase
ND446_04590	COG2976	Protein conserved in bacteria
ND446_04595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND446_04605	COG1645	bacterial-type flagellum-dependent swarming motility
ND446_04610	COG1570	exodeoxyribonuclease VII activity
ND446_04615	COG0516	GMP reductase activity
ND446_04615	COG0517	IMP dehydrogenase activity
ND446_04620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND446_04620	COG0519	Catalyzes the synthesis of GMP from XMP
ND446_04630	COG0351	phosphomethylpyrimidine kinase
ND446_04645	COG1597	lipid kinase activity
ND446_04650	COG0826	peptidase U32
ND446_04655	COG3422	double-strand break repair
ND446_04660	COG0745	RESPONSE REGULATOR receiver
ND446_04665	COG2205	protein histidine kinase activity
ND446_04670	COG0477	Major facilitator Superfamily
ND446_04675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND446_04685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND446_04705	COG3121	Chaperone
ND446_04715	COG0443	Heat shock 70 kDa protein
ND446_04720	COG2239	Acts as a magnesium transporter
ND446_04735	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND446_04740	COG0573	inorganic phosphate transmembrane transporter activity
ND446_04745	COG0581	inorganic phosphate transmembrane transporter activity
ND446_04755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND446_04760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND446_04765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND446_04770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND446_04775	COG2233	PERMEase
ND446_04780	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND446_04785	COG1393	Belongs to the ArsC family
ND446_04790	COG4783	chaperone-mediated protein folding
ND446_04795	COG0628	permease
ND446_04800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND446_04805	COG2716	regulation of RNA biosynthetic process
ND446_04810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND446_04815	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND446_04835	COG0400	carboxylic ester hydrolase activity
ND446_04845	COG1876	peptidase activity
ND446_04850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND446_04855	COG1393	Belongs to the ArsC family
ND446_04925	COG1605	Chorismate mutase
ND446_04935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND446_04945	COG2197	response regulator
ND446_04950	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND446_04950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND446_04955	COG3062	negative regulation of establishment of protein localization
ND446_04960	COG0243	molybdopterin cofactor binding
ND446_04965	COG3043	anaerobic respiration
ND446_04970	COG3005	denitrification pathway
ND446_04975	COG0494	nUDIX hydrolase
ND446_04980	COG0281	malic enzyme
ND446_04980	COG0280	phosphate acetyltransferase
ND446_04985	COG1671	Belongs to the UPF0178 family
ND446_05000	COG3111	PFAM Bacterial OB fold (BOF) protein
ND446_05010	COG2837	iron assimilation
ND446_05015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND446_05030	COG2731	YhcH YjgK YiaL family protein
ND446_05035	COG1737	Transcriptional regulator
ND446_05045	COG4150	thiosulfate binding
ND446_05050	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND446_05055	COG4208	sulfate ABC transporter
ND446_05065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND446_05080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND446_05090	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND446_05100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND446_05105	COG3530	Putative quorum-sensing-regulated virulence factor
ND446_05170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND446_05175	COG1914	H( )-stimulated, divalent metal cation uptake system
ND446_05195	COG0837	glucose binding
ND446_05200	COG2223	nitrite transmembrane transporter activity
ND446_05205	COG3279	Response regulator of the LytR AlgR family
ND446_05210	COG3275	phosphorelay sensor kinase activity
ND446_05220	COG0436	Aminotransferase
ND446_05225	COG3038	cytochrome b561
ND446_05235	COG1598	PFAM Uncharacterised protein family UPF0150
ND446_05240	COG2951	lytic endotransglycosylase activity
ND446_05245	COG2824	Alkylphosphonate utilization operon protein PhnA
ND446_05265	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND446_05270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND446_05275	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND446_05280	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND446_05285	COG1138	Cytochrome C-type biogenesis protein
ND446_05290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND446_05295	COG4235	cytochrome complex assembly
ND446_05295	COG3088	subunit of a heme lyase
ND446_05300	COG4235	cytochrome complex assembly
ND446_05300	COG3088	subunit of a heme lyase
ND446_05315	COG3691	Protein conserved in bacteria
ND446_05320	COG0183	Belongs to the thiolase family
ND446_05325	COG1024	Enoyl-CoA hydratase
ND446_05325	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND446_05330	COG2062	phosphohistidine phosphatase, SixA
ND446_05335	COG2840	Smr protein MutS2
ND446_05340	COG2890	protein-(glutamine-N5) methyltransferase activity
ND446_05350	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND446_05355	COG0730	response to heat
ND446_05360	COG3101	peptidyl-lysine hydroxylation
ND446_05375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND446_05405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND446_05410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND446_05435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND446_05445	COG0586	Pfam SNARE associated Golgi protein
ND446_05455	COG0285	dihydrofolate synthase activity
ND446_05460	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND446_05465	COG1286	toxin biosynthetic process
ND446_05470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND446_05475	COG0163	prenyltransferase activity
ND446_05490	COG4215	(ABC) transporter
ND446_05495	COG4160	amino acid transport
ND446_05505	COG1090	epimerase
ND446_05510	COG0625	glutathione transferase activity
ND446_05520	COG0622	Phosphoesterase
ND446_05525	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND446_05530	COG3037	sugar-specific permease SgaT UlaA
ND446_05545	COG1609	Transcriptional regulator
ND446_05550	COG0280	phosphate acetyltransferase
ND446_05550	COG0857	belongs to the CobB CobQ family
ND446_05560	COG3092	negative regulation of chromosome organization
ND446_05565	COG3013	Belongs to the UPF0304 family
ND446_05575	COG0471	metal ion transport
ND446_05575	COG0490	domain, Protein
ND446_05580	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND446_05585	COG0436	Aminotransferase
ND446_05590	COG0583	DNA-binding transcription factor activity
ND446_05595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND446_05600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND446_05620	COG1034	ATP synthesis coupled electron transport
ND446_05625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND446_05630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND446_05635	COG0839	Belongs to the complex I subunit 6 family
ND446_05645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND446_05650	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND446_05665	COG4575	ribosome binding
ND446_05670	COG1169	isochorismate synthase
ND446_05675	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND446_05680	COG0596	Alpha beta hydrolase
ND446_05685	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND446_05710	COG0814	amino acid
ND446_05725	COG2246	polysaccharide biosynthetic process
ND446_05735	COG4574	serine-type endopeptidase inhibitor activity
ND446_05745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND446_05755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND446_05760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND446_05770	COG2205	protein histidine kinase activity
ND446_05770	COG0784	Response regulator, receiver
ND446_05780	COG2198	Histidine kinase
ND446_05780	COG0642	Histidine kinase
ND446_05785	COG2223	nitrite transmembrane transporter activity
ND446_05810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND446_05840	COG3083	sulfuric ester hydrolase activity
ND446_05845	COG3082	Protein of unknown function (DUF1414)
ND446_05860	COG1061	Type III restriction enzyme res subunit
ND446_05865	COG1187	pseudouridine synthase activity
ND446_05870	COG2814	Major facilitator Superfamily
ND446_05880	COG4172	Belongs to the ABC transporter superfamily
ND446_05885	COG4239	(ABC) transporter, permease
ND446_05890	COG4174	ABC transporter (Permease)
ND446_05895	COG4166	transmembrane transport
ND446_05900	COG2200	EAL domain
ND446_05905	COG0791	NLP P60 protein
ND446_05910	COG0671	phosphoesterase, PA-phosphatase related
ND446_05915	COG0523	cobalamin synthesis protein
ND446_05925	COG0246	Mannitol dehydrogenase
ND446_05935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND446_05950	COG0243	molybdopterin cofactor binding
ND446_05955	COG3005	denitrification pathway
ND446_05970	COG1105	Belongs to the carbohydrate kinase PfkB family
ND446_05975	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND446_05975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND446_05975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND446_05980	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND446_05985	COG2855	membrane
ND446_05995	COG0583	DNA-binding transcription factor activity
ND446_06000	COG0833	amino acid
ND446_06010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND446_06020	COG4771	TonB-dependent receptor
ND446_06025	COG0531	amino acid
ND446_06030	COG2925	Exonuclease
ND446_06040	COG1289	transmembrane transporter activity
ND446_06060	COG3842	ATPase activity
ND446_06070	COG1840	ABC-type Fe3 transport system, periplasmic component
ND446_06075	COG2271	Major facilitator Superfamily
ND446_06090	COG4565	transcriptional regulatory protein
ND446_06095	COG3290	protein histidine kinase activity
ND446_06100	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND446_06105	COG3052	prosthetic group binding
ND446_06110	COG2301	Belongs to the HpcH HpaI aldolase family
ND446_06115	COG3051	citrate lyase alpha subunit
ND446_06130	COG0471	metal ion transport
ND446_06180	COG3321	synthase
ND446_06180	COG1028	Short-chain dehydrogenase reductase Sdr
ND446_06180	COG0604	alcohol dehydrogenase
ND446_06200	COG1609	Transcriptional regulator
ND446_06220	COG0840	transmembrane signaling receptor activity
ND446_06225	COG1285	pathogenesis
ND446_06235	COG0589	response to stress
ND446_06255	COG1360	Flagellar Motor Protein
ND446_06260	COG0643	Histidine kinase
ND446_06260	COG2198	Histidine kinase
ND446_06265	COG0835	chemotaxis
ND446_06270	COG0840	transmembrane signaling receptor activity
ND446_06275	COG0840	transmembrane signaling receptor activity
ND446_06280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND446_06290	COG0745	RESPONSE REGULATOR receiver
ND446_06295	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND446_06300	COG1404	Belongs to the peptidase S8 family
ND446_06300	COG4935	Belongs to the peptidase S8 family
ND446_06305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND446_06310	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND446_06325	COG3418	PFAM FlgN family protein
ND446_06330	COG2747	anti-sigma28 factor FlgM
ND446_06340	COG1815	bacterial-type flagellum-dependent cell motility
ND446_06345	COG1558	bacterial-type flagellum-dependent cell motility
ND446_06425	COG1580	Controls the rotational direction of flagella during chemotaxis
ND446_06440	COG1157	protein secretion by the type III secretion system
ND446_06450	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND446_06460	COG1677	Flagellar hook-basal body complex protein FliE
ND446_06470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND446_06475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND446_06515	COG1191	sigma factor activity
ND446_06525	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND446_06530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND446_06535	COG0765	amino acid transport
ND446_06540	COG1126	abc transporter atp-binding protein
ND446_06545	COG0506	proline dehydrogenase activity
ND446_06545	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND446_06545	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND446_06550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND446_06555	COG3710	Transcriptional regulator
ND446_06560	COG0531	amino acid
ND446_06570	COG1113	amino acid transport
ND446_06595	COG2197	response regulator
ND446_06600	COG0322	excinuclease ABC activity
ND446_06605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND446_06625	COG2801	Transposase and inactivated derivatives
ND446_06630	COG0840	transmembrane signaling receptor activity
ND446_06665	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND446_06670	COG2153	protein acetylation
ND446_06705	COG0531	amino acid
ND446_06710	COG0076	glutamate decarboxylase activity
ND446_06725	COG2235	arginine
ND446_06740	COG1757	Na H antiporter
ND446_06745	COG3122	Protein conserved in bacteria
ND446_06755	COG1187	pseudouridine synthase activity
ND446_06760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND446_06765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND446_06770	COG2723	6-phospho-beta-galactosidase activity
ND446_06775	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND446_06780	COG2169	Transcriptional regulator
ND446_06780	COG1917	Cupin 2, conserved barrel domain protein
ND446_06795	COG1278	Cold shock
ND446_06800	COG1278	Cold shock
ND446_06820	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND446_06840	COG5001	Diguanylate cyclase
ND446_06840	COG2203	Gaf domain
ND446_06840	COG3706	GGDEF domain
ND446_06840	COG4251	negative regulation of phosphorylation
ND446_06850	COG1132	(ABC) transporter
ND446_06870	COG2207	Transcriptional regulator
ND446_06905	COG1113	amino acid transport
ND446_06925	COG1496	oxidoreductase activity
ND446_06930	COG0768	penicillin binding
ND446_06935	COG2226	methyltransferase
ND446_06965	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND446_06975	COG1960	acyl-CoA dehydrogenase activity
ND446_06995	COG1971	Probably functions as a manganese efflux pump
ND446_07000	COG4811	Protein of unknown function (DUF986)
ND446_07005	COG3716	PTS system mannose fructose sorbose family IID component
ND446_07010	COG3715	PTS system
ND446_07015	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND446_07015	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND446_07020	COG1253	flavin adenine dinucleotide binding
ND446_07025	COG1760	l-serine dehydratase
ND446_07030	COG0494	nUDIX hydrolase
ND446_07050	COG0513	Belongs to the DEAD box helicase family
ND446_07055	COG3141	response to X-ray
ND446_07060	COG3097	Belongs to the UPF0267 family
ND446_07070	COG1770	oligopeptidase
ND446_07075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND446_07090	COG1528	Iron-storage protein
ND446_07095	COG2372	response to copper ion
ND446_07100	COG1276	copper resistance
ND446_07180	COG5001	Diguanylate cyclase
ND446_07180	COG4251	negative regulation of phosphorylation
ND446_07180	COG3706	GGDEF domain
ND446_07180	COG2203	Gaf domain
ND446_07185	COG3008	intermembrane lipid transfer
ND446_07190	COG2995	paraquat-inducible protein a
ND446_07195	COG1956	GAF domain-containing protein
ND446_07205	COG0793	Belongs to the peptidase S41A family
ND446_07210	COG0501	Belongs to the peptidase M48B family
ND446_07220	COG2814	Major facilitator Superfamily
ND446_07230	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND446_07235	COG1823	symporter activity
ND446_07240	COG1988	membrane-bound metal-dependent
ND446_07245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND446_07255	COG3001	Fructosamine kinase
ND446_07260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND446_07265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND446_07270	COG1121	(ABC) transporter
ND446_07275	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND446_07345	COG0776	regulation of translation
ND446_07415	COG4139	cobalamin transport
ND446_07425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND446_07430	COG0463	Glycosyl transferase, family 2
ND446_07445	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND446_07450	COG2076	Multidrug Resistance protein
ND446_07455	COG2076	Multidrug Resistance protein
ND446_07460	COG0791	NLP P60 protein
ND446_07465	COG0095	Lipoate-protein ligase
ND446_07475	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND446_07480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND446_07485	COG4558	Periplasmic binding protein
ND446_07490	COG3720	iron ion transport
ND446_07495	COG4771	TonB-dependent receptor
ND446_07505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND446_07510	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND446_07515	COG0574	Belongs to the PEP-utilizing enzyme family
ND446_07515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND446_07525	COG0628	permease
ND446_07530	COG0277	FAD linked oxidase domain protein
ND446_07530	COG0247	lactate metabolic process
ND446_07535	COG2050	protein possibly involved in aromatic compounds catabolism
ND446_07540	COG0316	Belongs to the HesB IscA family
ND446_07545	COG0719	Fe-S assembly protein
ND446_07550	COG0396	ATPase activity
ND446_07555	COG0719	Fe-S assembly protein
ND446_07565	COG2166	iron-sulfur cluster assembly
ND446_07570	COG1376	ErfK ybiS ycfS ynhG family protein
ND446_07570	COG1388	LysM domain
ND446_07605	COG0307	riboflavin synthase, alpha
ND446_07610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND446_07615	COG2814	Major facilitator Superfamily
ND446_07620	COG0583	DNA-binding transcription factor activity
ND446_07625	COG1609	Transcriptional regulator
ND446_07635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND446_07640	COG0791	NLP P60 protein
ND446_07645	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND446_07660	COG1902	pentaerythritol trinitrate reductase activity
ND446_07665	COG1309	transcriptional regulator
ND446_07670	COG2194	sulfuric ester hydrolase activity
ND446_07675	COG3313	Fe-S protein
ND446_07680	COG4989	oxidoreductase activity
ND446_07690	COG1846	Transcriptional regulator
ND446_07695	COG3133	Outer membrane lipoprotein
ND446_07700	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND446_07745	COG0484	heat shock protein binding
ND446_07755	COG3104	oligopeptide transport
ND446_07765	COG4172	Belongs to the ABC transporter superfamily
ND446_07770	COG4172	Belongs to the ABC transporter superfamily
ND446_07775	COG4171	peptide transport system, permease
ND446_07785	COG4166	transmembrane transport
ND446_07800	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND446_07805	COG1842	Phage shock protein A
ND446_07815	COG1983	PspC domain protein
ND446_07825	COG3106	COG3106 Predicted ATPase
ND446_07830	COG3768	UPF0283 membrane protein
ND446_07835	COG5654	RES domain protein
ND446_07840	COG5642	Protein of unknown function (DUF2384)
ND446_07850	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND446_07855	COG4948	Mandelate Racemase Muconate Lactonizing
ND446_07860	COG2866	Carboxypeptidase
ND446_07865	COG4166	transmembrane transport
ND446_07880	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND446_07880	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND446_07880	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND446_07880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND446_07890	COG1285	pathogenesis
ND446_07895	COG3042	response to heat
ND446_07900	COG3187	Heat shock protein
ND446_07905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND446_07910	COG2911	Protein conserved in bacteria
ND446_07925	COG3784	Protein of unknown function (DUF1318)
ND446_07930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND446_07935	COG1643	Atp-dependent helicase
ND446_07940	COG3591	Belongs to the peptidase S1B family
ND446_07950	COG1881	PFAM PEBP family protein
ND446_07955	COG2207	Transcriptional regulator
ND446_07970	COG2205	protein histidine kinase activity
ND446_07975	COG0745	RESPONSE REGULATOR receiver
ND446_07985	COG0531	amino acid
ND446_07995	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND446_08000	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND446_08005	COG3623	hexulose-6-phosphate isomerase
ND446_08010	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND446_08040	COG0589	response to stress
ND446_08045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND446_08050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND446_08055	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND446_08065	COG1011	Hydrolase
ND446_08105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND446_08120	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND446_08125	COG4221	oxidoreductase activity
ND446_08130	COG1742	UPF0060 membrane protein
ND446_08150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND446_08155	COG1940	carbohydrate kinase activity
ND446_08175	COG0114	fumarate hydratase activity
ND446_08180	COG1482	cell wall glycoprotein biosynthetic process
ND446_08185	COG5339	Protein conserved in bacteria
ND446_08205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND446_08210	COG0385	Bile acid
ND446_08215	COG0673	inositol 2-dehydrogenase activity
ND446_08225	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND446_08235	COG4657	Part of a membrane complex involved in electron transport
ND446_08250	COG3708	Transcriptional regulator
ND446_08250	COG2207	Transcriptional regulator
ND446_08260	COG4659	FMN binding
ND446_08270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND446_08275	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND446_08280	COG5001	Diguanylate cyclase
ND446_08280	COG3447	MASE1 domain protein
ND446_08280	COG5002	protein histidine kinase activity
ND446_08285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND446_08295	COG0023	Translation Initiation Factor
ND446_08315	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND446_08320	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND446_08325	COG0671	phosphoesterase, PA-phosphatase related
ND446_08335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND446_08355	COG0583	DNA-binding transcription factor activity
ND446_08370	COG0616	signal peptide processing
ND446_08375	COG1028	Short-chain dehydrogenase reductase Sdr
ND446_08385	COG1187	pseudouridine synthase activity
ND446_08390	COG0009	L-threonylcarbamoyladenylate synthase
ND446_08395	COG0613	PHP domain protein
ND446_08405	COG0512	Glutamine amidotransferase of anthranilate synthase
ND446_08415	COG0135	phosphoribosylanthranilate isomerase activity
ND446_08415	COG0134	indole-3-glycerol-phosphate synthase activity
ND446_08420	COG0133	tryptophan synthase activity
ND446_08435	COG3047	cAMP biosynthetic process
ND446_08440	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND446_08465	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND446_08500	COG3710	Transcriptional regulator
ND446_08515	COG2350	Protein conserved in bacteria
ND446_08535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND446_08540	COG3099	Belongs to the UPF0263 family
ND446_08555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND446_08575	COG2095	MarC family integral membrane protein
ND446_08585	COG1454	alcohol dehydrogenase
ND446_08585	COG1012	belongs to the aldehyde dehydrogenase family
ND446_08605	COG0745	RESPONSE REGULATOR receiver
ND446_08610	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND446_08620	COG0788	formyltetrahydrofolate deformylase activity
ND446_08655	COG0708	Exodeoxyribonuclease III
ND446_08660	COG0494	nUDIX hydrolase
ND446_08670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND446_08680	COG0778	Nitroreductase
ND446_08685	COG0616	signal peptide processing
ND446_08690	COG0252	asparaginase activity
ND446_08695	COG1335	isochorismatase
ND446_08700	COG3139	Protein of unknown function (DUF1315)
ND446_08705	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND446_08720	COG2194	sulfuric ester hydrolase activity
ND446_08725	COG3713	MltA-interacting MipA family protein
ND446_08735	COG2766	serine protein kinase
ND446_08740	COG2718	Belongs to the UPF0229 family
ND446_08770	COG2814	Major facilitator Superfamily
ND446_08775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND446_08780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND446_08785	COG2719	SpoVR family
ND446_08795	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND446_08815	COG2983	Belongs to the UPF0260 family
ND446_08820	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND446_08825	COG3100	YcgL domain-containing protein
ND446_08830	COG0850	regulation of cytokinetic process
ND446_08835	COG2894	cell division
ND446_08840	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND446_08845	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND446_08850	COG0318	PFAM AMP-dependent synthetase and ligase
ND446_08855	COG3065	identical protein binding
ND446_08860	COG1214	PFAM Peptidase M22, glycoprotease
ND446_08865	COG1199	ATP-dependent helicase activity
ND446_08870	COG0251	oxidation-reduction process
ND446_08875	COG2076	Multidrug Resistance protein
ND446_08885	COG0800	Aldolase
ND446_08890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND446_08895	COG1737	Transcriptional regulator
ND446_08900	COG0469	pyruvate kinase activity
ND446_08905	COG1560	Kdo2-lipid A biosynthetic process
ND446_08910	COG0739	heme binding
ND446_08915	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND446_08920	COG1121	(ABC) transporter
ND446_08925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND446_08930	COG3104	oligopeptide transport
ND446_08935	COG2255	four-way junction helicase activity
ND446_08945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND446_08955	COG0494	nUDIX hydrolase
ND446_08960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND446_08970	COG1801	Protein of unknown function DUF72
ND446_08975	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND446_08990	COG3142	Participates in the control of copper homeostasis
ND446_08995	COG3102	Protein conserved in bacteria
ND446_09020	COG0728	peptidoglycan biosynthetic process
ND446_09025	COG0673	inositol 2-dehydrogenase activity
ND446_09035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND446_09055	COG3381	protein complex oligomerization
ND446_09065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND446_09090	COG3706	GGDEF domain
ND446_09095	COG0659	secondary active sulfate transmembrane transporter activity
ND446_09100	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND446_09115	COG2890	protein-(glutamine-N5) methyltransferase activity
ND446_09120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND446_09125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND446_09130	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND446_09140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND446_09150	COG0193	aminoacyl-tRNA hydrolase activity
ND446_09160	COG0012	GTP binding
ND446_09180	COG0309	Hydrogenase expression formation protein (HypE)
ND446_09185	COG0409	Hydrogenase expression formation protein
ND446_09190	COG0298	carbon dioxide binding
ND446_09195	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND446_09200	COG0375	protein maturation
ND446_09210	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND446_09215	COG0651	ATP synthesis coupled electron transport
ND446_09220	COG0650	Formate hydrogenlyase subunit 4
ND446_09225	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND446_09225	COG3261	NADH dehydrogenase
ND446_09230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND446_09235	COG3260	NADH ubiquinone oxidoreductase 20
ND446_09245	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND446_09250	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND446_09255	COG3383	formate dehydrogenase (NAD+) activity
ND446_09260	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND446_09265	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND446_09285	COG0402	S-adenosylhomocysteine deaminase activity
ND446_09295	COG1228	amidohydrolase
ND446_09315	COG3724	N-succinylarginine dihydrolase activity
ND446_09325	COG3138	arginine N-succinyltransferase
ND446_09330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND446_09335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND446_09340	COG1271	oxidase subunit
ND446_09345	COG1294	oxidase, subunit
ND446_09355	COG3850	Histidine kinase
ND446_09360	COG2375	cellular response to nickel ion
ND446_09365	COG0387	Pfam Sodium calcium exchanger
ND446_09370	COG1702	phosphate starvation-inducible protein PhoH
ND446_09375	COG4977	sequence-specific DNA binding
ND446_09415	COG0471	metal ion transport
ND446_09420	COG3290	protein histidine kinase activity
ND446_09425	COG4565	transcriptional regulatory protein
ND446_09430	COG3493	citrate carrier protein
ND446_09435	COG0840	transmembrane signaling receptor activity
ND446_09440	COG0840	transmembrane signaling receptor activity
ND446_09445	COG0339	signal peptide processing
ND446_09455	COG2723	6-phospho-beta-galactosidase activity
ND446_09460	COG3916	Acyl-homoserine-lactone synthase
ND446_09465	COG2771	luxR family
ND446_09470	COG0538	isocitrate dehydrogenase activity
ND446_09475	COG1187	pseudouridine synthase activity
ND446_09485	COG0482	sulfurtransferase activity
ND446_09490	COG2915	High frequency lysogenization protein hflD homolog
ND446_09495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND446_09505	COG0745	RESPONSE REGULATOR receiver
ND446_09510	COG2205	protein histidine kinase activity
ND446_09515	COG2850	peptidyl-arginine hydroxylation
ND446_09535	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND446_09545	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND446_09550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND446_09555	COG3134	Outer membrane lipoprotein
ND446_09560	COG1252	NADH dehydrogenase
ND446_09565	COG3150	esterase
ND446_09580	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND446_09585	COG5633	Lipoprotein
ND446_09590	COG0537	adenosine 5'-monophosphoramidase activity
ND446_09595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND446_09595	COG1263	PTS System
ND446_09600	COG0084	hydrolase, TatD family'
ND446_09605	COG0470	DNA polymerase III
ND446_09610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND446_09615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND446_09620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND446_09625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND446_09630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND446_09640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND446_09645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND446_09655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND446_09660	COG1399	metal-binding, possibly nucleic acid-binding protein
ND446_09665	COG0424	maF-like protein
ND446_09670	COG0564	pseudouridine synthase activity
ND446_09675	COG1530	ribonuclease E activity
ND446_09685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND446_09690	COG0418	dihydroorotase activity
ND446_09715	COG0628	permease
ND446_09725	COG1560	Kdo2-lipid A biosynthetic process
ND446_09740	COG0346	lactoylglutathione lyase activity
ND446_09745	COG2943	transferase activity, transferring hexosyl groups
ND446_09750	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND446_09770	COG0288	reversible hydration of carbon dioxide
ND446_09780	COG2920	part of a sulfur-relay system
ND446_09785	COG1254	Belongs to the acylphosphatase family
ND446_09790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND446_09795	COG3785	DNA binding
ND446_09800	COG1832	CoA-binding protein
ND446_09810	COG1803	Methylglyoxal synthase
ND446_09815	COG0210	DNA helicase
ND446_09820	COG3304	Inner membrane component domain
ND446_09825	COG1289	transmembrane transporter activity
ND446_09830	COG3070	regulator of competence-specific genes
ND446_09835	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND446_09845	COG3120	sequence-specific DNA binding
ND446_09850	COG1067	ATP-dependent peptidase activity
ND446_09855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND446_09860	COG3130	regulation of translation
ND446_09865	COG3009	Protein conserved in bacteria
ND446_09870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND446_09870	COG3008	intermembrane lipid transfer
ND446_09875	COG2995	paraquat-inducible protein a
ND446_09880	COG0488	(ABC) transporter
ND446_09885	COG0116	Belongs to the methyltransferase superfamily
ND446_09885	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND446_09890	COG3217	Mosc domain protein beta barrel domain protein
ND446_09890	COG0633	Ferredoxin
ND446_09900	COG0167	dihydroorotate dehydrogenase activity
ND446_09905	COG0308	aminopeptidase N
ND446_09910	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND446_09925	COG1448	Aminotransferase
ND446_09930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND446_09935	COG3108	Peptidase M15
ND446_09940	COG2989	Protein conserved in bacteria
ND446_09945	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND446_09955	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND446_09960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND446_09965	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND446_09970	COG3173	Aminoglycoside phosphotransferase
ND446_09975	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND446_09980	COG2835	tetraacyldisaccharide 4'-kinase activity
ND446_09985	COG1278	Cold shock
ND446_09995	COG5383	Protein conserved in bacteria
ND446_10000	COG1663	tetraacyldisaccharide 4'-kinase activity
ND446_10010	COG2333	competence protein COMEC
ND446_10010	COG0658	competence protein
ND446_10020	COG0539	negative regulation of cytoplasmic translation
ND446_10030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND446_10040	COG0252	asparaginase activity
ND446_10045	COG1944	ATP diphosphatase activity
ND446_10050	COG2116	formate transmembrane transporter activity
ND446_10055	COG1882	Formate acetyltransferase
ND446_10060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND446_10065	COG2814	Major facilitator Superfamily
ND446_10070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND446_10075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND446_10080	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND446_10085	COG3107	peptidoglycan biosynthetic process
ND446_10085	COG1674	ftsk spoiiie
ND446_10090	COG1522	sequence-specific DNA binding
ND446_10095	COG0492	ferredoxin-NADP+ reductase activity
ND446_10105	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND446_10115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND446_10120	COG0542	response to heat
ND446_10125	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND446_10130	COG1278	Cold shock
ND446_10140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND446_10145	COG2990	Protein conserved in bacteria
ND446_10150	COG3593	DNA synthesis involved in DNA repair
ND446_10155	COG2431	L-lysine efflux transmembrane transporter activity
ND446_10160	COG1151	hydroxylamine reductase activity
ND446_10165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND446_10170	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND446_10175	COG0702	epimerase
ND446_10180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND446_10185	COG0393	Putative heavy-metal-binding
ND446_10195	COG1126	abc transporter atp-binding protein
ND446_10200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND446_10205	COG4215	(ABC) transporter
ND446_10210	COG4160	amino acid transport
ND446_10215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND446_10230	COG1177	transmembrane transport
ND446_10235	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND446_10240	COG3842	ATPase activity
ND446_10245	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND446_10265	COG2985	domain, Protein
ND446_10265	COG0569	domain protein
ND446_10275	COG0671	phosphoesterase, PA-phosphatase related
ND446_10285	COG1349	DNA-binding transcription factor activity
ND446_10290	COG0814	amino acid
ND446_10295	COG1760	l-serine dehydratase
ND446_10300	COG1686	Belongs to the peptidase S11 family
ND446_10310	COG0626	cystathionine gamma-synthase activity
ND446_10325	COG0625	glutathione transferase activity
ND446_10330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND446_10345	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND446_10350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND446_10355	COG0131	Imidazoleglycerol-phosphate dehydratase
ND446_10355	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND446_10365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND446_10375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND446_10375	COG0140	phosphoribosyl-ATP diphosphatase activity
ND446_10385	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND446_10390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND446_10395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND446_10400	COG1253	flavin adenine dinucleotide binding
ND446_10405	COG3069	C4-dicarboxylate transmembrane transporter activity
ND446_10410	COG2982	Protein involved in outer membrane biogenesis
ND446_10415	COG0717	Belongs to the dCTP deaminase family
ND446_10420	COG0572	uridine kinase
ND446_10425	COG0489	protein tyrosine kinase activity
ND446_10430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND446_10430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND446_10440	COG1380	Effector of murein hydrolase LrgA
ND446_10445	COG1346	cytolysis
ND446_10455	COG0583	DNA-binding transcription factor activity
ND446_10465	COG0281	malic enzyme
ND446_10470	COG2949	membrane
ND446_10495	COG2311	Membrane
ND446_10500	COG0302	gtp cyclohydrolase
ND446_10505	COG0477	Major facilitator Superfamily
ND446_10510	COG0583	DNA-binding transcription factor activity
ND446_10530	COG0303	'Molybdopterin
ND446_10535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND446_10540	COG0488	(ABC) transporter
ND446_10545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND446_10550	COG2239	Acts as a magnesium transporter
ND446_10555	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND446_10575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND446_10580	COG0765	amino acid transport
ND446_10585	COG1126	abc transporter atp-binding protein
ND446_10590	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND446_10595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND446_10610	COG0697	spore germination
ND446_10620	COG1982	Orn Lys Arg decarboxylase major
ND446_10625	COG0531	amino acid
ND446_10630	COG1174	glycine betaine transport
ND446_10635	COG1125	glycine betaine transport
ND446_10640	COG1174	glycine betaine transport
ND446_10645	COG1732	Glycine betaine
ND446_10650	COG2897	thiosulfate sulfurtransferase activity
ND446_10655	COG4807	Protein conserved in bacteria
ND446_10660	COG3639	organic phosphonate transmembrane transporter activity
ND446_10670	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND446_10680	COG2261	transglycosylase associated protein
ND446_10700	COG0277	FAD linked oxidase domain protein
ND446_10705	COG1686	Belongs to the peptidase S11 family
ND446_10715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND446_10720	COG0513	Belongs to the DEAD box helicase family
ND446_10725	COG1309	transcriptional regulator
ND446_10730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND446_10735	COG1131	(ABC) transporter
ND446_10740	COG0842	Transport permease protein
ND446_10745	COG0842	Transport permease protein
ND446_10750	COG0670	Belongs to the BI1 family
ND446_10755	COG0314	molybdopterin synthase activity
ND446_10760	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND446_10770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND446_10775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND446_10780	COG1120	ATPase activity
ND446_10785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND446_10800	COG4628	conserved protein (DUF2132)
ND446_10805	COG0556	nucleotide-excision repair
ND446_10820	COG2226	methyltransferase
ND446_10825	COG0156	8-amino-7-oxononanoate synthase activity
ND446_10840	COG2706	6-phosphogluconolactonase activity
ND446_10845	COG0561	phosphatase activity
ND446_10855	COG4149	molybdate abc transporter
ND446_10860	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND446_10870	COG3585	molybdate ion transport
ND446_10870	COG2005	Transcriptional regulator
ND446_10885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND446_10890	COG1085	galactose-1-phosphate uridylyltransferase
ND446_10900	COG2017	converts alpha-aldose to the beta-anomer
ND446_10910	COG0588	phosphoglycerate mutase activity
ND446_10915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND446_10925	COG2205	protein histidine kinase activity
ND446_10925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND446_10935	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND446_10965	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND446_10970	COG2885	chlorophyll binding
ND446_10975	COG0823	Involved in the tonB-independent uptake of proteins
ND446_10980	COG3064	Membrane
ND446_10980	COG3064	Membrane
ND446_10985	COG0848	biopolymer transport protein
ND446_10990	COG0811	peptide transport
ND446_10995	COG0824	Thioesterase
ND446_11000	COG3790	cyd operon protein YbgE
ND446_11005	COG4890	Cyd operon protein YbgT
ND446_11010	COG1294	oxidase, subunit
ND446_11015	COG1271	oxidase subunit
ND446_11020	COG0737	Belongs to the 5'-nucleotidase family
ND446_11025	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND446_11030	COG0045	succinate-CoA ligase (ADP-forming) activity
ND446_11035	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND446_11040	COG0567	Dehydrogenase, E1 component
ND446_11045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND446_11050	COG1053	succinate dehydrogenase
ND446_11055	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND446_11090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND446_11095	COG1984	allophanate hydrolase subunit 2
ND446_11100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND446_11105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND446_11110	COG5212	phosphodiesterase
ND446_11115	COG0415	Belongs to the DNA photolyase family
ND446_11120	COG3272	Protein of unknown function (DUF1722)
ND446_11140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND446_11145	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND446_11150	COG2205	protein histidine kinase activity
ND446_11155	COG0745	RESPONSE REGULATOR receiver
ND446_11165	COG0033	Phosphoglucomutase
ND446_11170	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND446_11175	COG0596	Alpha beta hydrolase
ND446_11185	COG0840	transmembrane signaling receptor activity
ND446_11195	COG0735	belongs to the Fur family
ND446_11220	COG2190	(PTS) system
ND446_11220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND446_11220	COG1263	PTS System
ND446_11230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND446_11235	COG1940	carbohydrate kinase activity
ND446_11235	COG1846	Transcriptional regulator
ND446_11240	COG0647	UMP catabolic process
ND446_11245	COG0367	asparagine synthase
ND446_11280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND446_11285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND446_11290	COG1702	phosphate starvation-inducible protein PhoH
ND446_11295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND446_11300	COG4535	Mg2 and Co2 transporter CorC
ND446_11305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND446_11315	COG0765	amino acid transport
ND446_11320	COG0765	amino acid transport
ND446_11325	COG1126	abc transporter atp-binding protein
ND446_11330	COG2888	peptidyl-tyrosine sulfation
ND446_11340	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND446_11345	COG1466	dna polymerase III delta subunit
ND446_11350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND446_11355	COG0799	negative regulation of ribosome biogenesis
ND446_11360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND446_11365	COG0768	penicillin binding
ND446_11370	COG0772	Belongs to the SEDS family
ND446_11375	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND446_11380	COG1686	Belongs to the peptidase S11 family
ND446_11385	COG2921	Belongs to the UPF0250 family
ND446_11395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND446_11405	COG3706	GGDEF domain
ND446_11425	COG1278	Cold shock
ND446_11430	COG2197	response regulator
ND446_11460	COG1309	transcriptional regulator
ND446_11475	COG3250	beta-galactosidase activity
ND446_11495	COG1215	transferase activity, transferring glycosyl groups
ND446_11505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND446_11535	COG3038	cytochrome b561
ND446_11570	COG1393	Belongs to the ArsC family
ND446_11575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND446_11590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND446_11595	COG2501	S4 domain
ND446_11625	COG3121	Chaperone
ND446_11630	COG3188	usher protein
ND446_11655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND446_11660	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND446_11665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND446_11670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND446_11675	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND446_11680	COG4181	ATPase activity
ND446_11685	COG2755	lipolytic protein G-D-S-L family
ND446_11690	COG0300	oxidoreductase activity
ND446_11695	COG3118	belongs to the thioredoxin family
ND446_11700	COG0330	HflC and HflK could
ND446_11705	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND446_11710	COG0789	Transcriptional regulator
ND446_11715	COG2217	Heavy metal translocating P-type atpase
ND446_11720	COG3735	TraB family
ND446_11725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND446_11730	COG0737	Belongs to the 5'-nucleotidase family
ND446_11735	COG4651	solute:proton antiporter activity
ND446_11735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND446_11740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND446_11750	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND446_11755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND446_11790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND446_11810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND446_11810	COG0543	2 iron, 2 sulfur cluster binding
ND446_11815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ND446_11825	COG0326	Molecular chaperone. Has ATPase activity
ND446_11830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND446_11870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND446_11875	COG2832	Protein of unknown function (DUF454)
ND446_11890	COG3264	Mechanosensitive ion channel
ND446_11890	COG1196	nuclear chromosome segregation
ND446_11895	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND446_11900	COG1309	transcriptional regulator
ND446_11905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND446_11910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND446_11915	COG0254	rRNA binding
ND446_11920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND446_11945	COG3695	enzyme binding
ND446_11950	COG1946	Acyl-CoA thioesterase
ND446_11955	COG0004	ammonium transporteR
ND446_11960	COG0347	Belongs to the P(II) protein family
ND446_11965	COG1132	(ABC) transporter
ND446_11970	COG1132	(ABC) transporter
ND446_11975	COG1522	sequence-specific DNA binding
ND446_11990	COG4533	DNA binding
ND446_11995	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND446_12000	COG0824	Thioesterase
ND446_12005	COG1555	photosystem II stabilization
ND446_12010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND446_12015	COG0776	regulation of translation
ND446_12020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND446_12025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND446_12030	COG0740	serine-type endopeptidase activity
ND446_12040	COG0271	Belongs to the BolA IbaG family
ND446_12045	COG3056	Lipoprotein
ND446_12050	COG2223	nitrite transmembrane transporter activity
ND446_12060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND446_12065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND446_12070	COG1845	cytochrome c oxidase, subunit III
ND446_12075	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND446_12085	COG2814	Major facilitator Superfamily
ND446_12090	COG1666	GTP binding
ND446_12095	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND446_12100	COG0693	protein deglycase activity
ND446_12135	COG0142	geranyltranstransferase activity
ND446_12140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND446_12145	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND446_12150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND446_12160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND446_12165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND446_12165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND446_12170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND446_12175	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND446_12180	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND446_12185	COG1862	Preprotein translocase
ND446_12200	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND446_12205	COG0450	alkyl hydroperoxide reductase
ND446_12210	COG0300	oxidoreductase activity
ND446_12215	COG0366	Alpha amylase catalytic
ND446_12220	COG1113	amino acid transport
ND446_12235	COG5002	protein histidine kinase activity
ND446_12240	COG0745	RESPONSE REGULATOR receiver
ND446_12245	COG0420	3'-5' exonuclease activity
ND446_12250	COG0419	ATPase involved in DNA repair
ND446_12255	COG1940	carbohydrate kinase activity
ND446_12260	COG2974	May be involved in recombination
ND446_12270	COG4126	flavin adenine dinucleotide binding
ND446_12290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND446_12325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND446_12340	COG1073	alpha beta
ND446_12345	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND446_12350	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND446_12355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND446_12365	COG2991	Protein conserved in bacteria
ND446_12370	COG1477	protein flavinylation
ND446_12380	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND446_12385	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND446_12390	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND446_12395	COG1805	sodium ion transport
ND446_12405	COG3034	peptidoglycan biosynthetic process
ND446_12410	COG0121	glutamine amidotransferase
ND446_12415	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND446_12420	COG1960	acyl-CoA dehydrogenase activity
ND446_12430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND446_12440	COG2226	methyltransferase
ND446_12450	COG1388	LysM domain
ND446_12450	COG0741	lytic transglycosylase activity
ND446_12455	COG3021	interspecies interaction between organisms
ND446_12490	COG0542	response to heat
ND446_12495	COG1496	oxidoreductase activity
ND446_12500	COG0564	pseudouridine synthase activity
ND446_12505	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND446_12510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND446_12515	COG1605	Chorismate mutase
ND446_12515	COG0077	Prephenate dehydratase
ND446_12520	COG1605	Chorismate mutase
ND446_12520	COG0287	Prephenate dehydrogenase
ND446_12525	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND446_12530	COG3279	Response regulator of the LytR AlgR family
ND446_12535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND446_12540	COG3137	Salt-induced outer membrane protein
ND446_12545	COG0335	large ribosomal subunit rRNA binding
ND446_12550	COG0336	Belongs to the RNA methyltransferase TrmD family
ND446_12555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND446_12565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND446_12570	COG4137	Cytochrome C assembly protein
ND446_12575	COG4536	flavin adenine dinucleotide binding
ND446_12580	COG1854	S-ribosylhomocysteine lyase activity
ND446_12585	COG2918	glutathione biosynthetic process
ND446_12590	COG1238	metal cluster binding
ND446_12595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND446_12630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND446_12635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND446_12640	COG2137	regulation of response to DNA damage stimulus
ND446_12645	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND446_12660	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND446_12660	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND446_12685	COG3031	protein transport across the cell outer membrane
ND446_12695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND446_12760	COG3397	chitin binding
ND446_12780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND446_12910	COG0741	lytic transglycosylase activity
ND446_12930	COG0784	Response regulator, receiver
ND446_12930	COG2205	protein histidine kinase activity
ND446_12940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND446_12945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND446_12950	COG4942	peptidase
ND446_12950	COG1388	LysM domain
ND446_12960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND446_12965	COG0585	pseudouridine synthase activity
ND446_12970	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND446_12980	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND446_12990	COG0529	Catalyzes the synthesis of activated sulfate
ND446_12995	COG2895	sulfate adenylyltransferase (ATP) activity
ND446_13000	COG0175	sulfate reduction
ND446_13005	COG1648	precorrin-2 dehydrogenase activity
ND446_13005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND446_13010	COG2234	aminopeptidase activity
ND446_13025	COG0175	sulfate reduction
ND446_13035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND446_13040	COG0720	synthase
ND446_13045	COG0602	queuosine metabolic process
ND446_13055	COG0504	CTP synthase activity
ND446_13060	COG3956	TIGRFAM MazG family protein
ND446_13065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND446_13070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND446_13080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND446_13085	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND446_13090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND446_13100	COG2860	membrane
ND446_13105	COG0316	Belongs to the HesB IscA family
ND446_13115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND446_13120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND446_13125	COG1643	Atp-dependent helicase
ND446_13130	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND446_13135	COG1489	DNA binding
ND446_13150	COG0617	tRNA 3'-terminal CCA addition
ND446_13155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND446_13160	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND446_13165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND446_13170	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND446_13175	COG0726	polysaccharide deacetylase
ND446_13180	COG0842	Transport permease protein
ND446_13185	COG1131	(ABC) transporter
ND446_13190	COG0288	reversible hydration of carbon dioxide
ND446_13200	COG2132	Multicopper oxidase
ND446_13210	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND446_13225	COG3112	Uncharacterised protein family (UPF0231)
ND446_13230	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND446_13250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND446_13255	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND446_13260	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND446_13265	COG2186	Transcriptional regulator
ND446_13270	COG1113	amino acid transport
ND446_13280	COG3725	Membrane protein required for beta-lactamase induction
ND446_13295	COG4969	Belongs to the N-Me-Phe pilin family
ND446_13300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND446_13305	COG1459	type II secretion system
ND446_13310	COG0516	GMP reductase activity
ND446_13330	COG0494	nUDIX hydrolase
ND446_13355	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND446_13360	COG0849	cell division
ND446_13365	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND446_13375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND446_13380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND446_13385	COG0772	Belongs to the SEDS family
ND446_13400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND446_13405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND446_13410	COG0768	penicillin binding
ND446_13415	COG3116	cell division
ND446_13420	COG0275	rRNA processing
ND446_13445	COG0028	Belongs to the TPP enzyme family
ND446_13450	COG1022	Amp-dependent synthetase and ligase
ND446_13465	COG0473	3-isopropylmalate dehydrogenase activity
ND446_13470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND446_13480	COG2814	Major facilitator Superfamily
ND446_13495	COG4143	(ABC) transporter
ND446_13500	COG1178	ABC-type Fe3 transport system permease component
ND446_13510	COG0586	Pfam SNARE associated Golgi protein
ND446_13515	COG0417	DNA replication proofreading
ND446_13520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND446_13525	COG0564	pseudouridine synthase activity
ND446_13535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND446_13545	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND446_13550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND446_13555	COG2967	ApaG domain
ND446_13580	COG2966	Psort location CytoplasmicMembrane, score
ND446_13590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND446_13605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND446_13610	COG1047	Peptidyl-prolyl cis-trans
ND446_13615	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND446_13625	COG0196	riboflavin kinase activity
ND446_13635	COG0583	DNA-binding transcription factor activity
ND446_13640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND446_13650	COG0443	Heat shock 70 kDa protein
ND446_13655	COG1584	GPR1 FUN34 yaaH family protein
ND446_13670	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND446_13675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND446_13710	COG0745	RESPONSE REGULATOR receiver
ND446_13715	COG3045	CreA protein
ND446_13720	COG2207	Transcriptional regulator
ND446_13720	COG3708	Transcriptional regulator
ND446_13725	COG0406	alpha-ribazole phosphatase activity
ND446_13730	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND446_13735	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND446_13740	COG0741	lytic transglycosylase activity
ND446_13760	COG0488	(ABC) transporter
ND446_13775	COG0560	Phosphoserine phosphatase
ND446_13780	COG3726	membrane protein affecting hemolysin expression
ND446_13790	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND446_13805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND446_13810	COG0084	hydrolase, TatD family'
ND446_13815	COG4667	esterase of the alpha-beta hydrolase superfamily
ND446_13825	COG2823	Periplasmic or secreted lipoprotein
ND446_13840	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND446_13880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND446_13880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND446_13880	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND446_13885	COG1461	Dihydroxyacetone kinase
ND446_13890	COG2376	Dihydroxyacetone kinase
ND446_13900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND446_13905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND446_13920	COG0859	PFAM glycosyl transferase family 9
ND446_13945	COG3119	arylsulfatase activity
ND446_13950	COG0641	radical SAM
ND446_13960	COG1028	Short-chain dehydrogenase reductase Sdr
ND446_13970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND446_13980	COG3716	PTS system mannose fructose sorbose family IID component
ND446_13985	COG3715	PTS system
ND446_13990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND446_13995	COG2222	sugar isomerase
ND446_14005	COG1349	DNA-binding transcription factor activity
ND446_14010	COG3119	arylsulfatase activity
ND446_14030	COG5492	domain, Protein
ND446_14120	COG3077	Addiction module antitoxin, RelB DinJ family
ND446_14145	COG0795	lipopolysaccharide-transporting ATPase activity
ND446_14150	COG0795	lipopolysaccharide-transporting ATPase activity
ND446_14155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND446_14160	COG2927	DNA polymerase III (CHI subunit)
ND446_14175	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND446_14195	COG3624	Phosphonate C-P lyase system protein PhnG
ND446_14200	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND446_14205	COG3626	phosphonate metabolism
ND446_14210	COG3627	carbon phosphorus lyase activity
ND446_14215	COG4107	phosphonate C-P lyase system protein PhnK
ND446_14220	COG4778	phosphonate C-P lyase system protein PhnL
ND446_14225	COG3454	Phosphonate metabolism
ND446_14230	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND446_14235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND446_14240	COG0702	epimerase
ND446_14245	COG3787	Belongs to the UPF0306 family
ND446_14255	COG1982	Orn Lys Arg decarboxylase major
ND446_14260	COG0531	amino acid
ND446_14265	COG2827	Endonuclease containing a URI domain
ND446_14270	COG3153	acetyltransferase
ND446_14275	COG3154	lipid carrier protein
ND446_14280	COG0826	peptidase U32
ND446_14285	COG0826	peptidase U32
ND446_14295	COG0814	amino acid
ND446_14300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND446_14305	COG0513	Belongs to the DEAD box helicase family
ND446_14315	COG1185	polyribonucleotide nucleotidyltransferase activity
ND446_14330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND446_14340	COG0195	Participates in both transcription termination and antitermination
ND446_14360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND446_14365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND446_14370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND446_14380	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND446_14385	COG1534	Rna-binding protein
ND446_14395	COG2027	D-alanyl-D-alanine carboxypeptidase
ND446_14400	COG0745	RESPONSE REGULATOR receiver
ND446_14405	COG0642	Histidine kinase
ND446_14410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND446_14415	COG0697	spore germination
ND446_14430	COG0142	geranyltranstransferase activity
ND446_14445	COG3423	Transcriptional regulator
ND446_14460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND446_14470	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND446_14475	COG2105	PFAM AIG2 family protein
ND446_14480	COG2911	Protein conserved in bacteria
ND446_14485	COG0729	surface antigen
ND446_14490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND446_14495	COG1253	flavin adenine dinucleotide binding
ND446_14505	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND446_14510	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND446_14515	COG0737	Belongs to the 5'-nucleotidase family
ND446_14525	COG0545	Peptidyl-prolyl cis-trans isomerase
ND446_14530	COG3061	Opacity-associated protein A
ND446_14535	COG0359	binds to the 23S rRNA
ND446_14540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND446_14545	COG2965	DNA replication, synthesis of RNA primer
ND446_14550	COG0360	Binds together with S18 to 16S ribosomal RNA
ND446_14560	COG1073	alpha beta
ND446_14580	COG3188	usher protein
ND446_14585	COG3121	Chaperone
ND446_14605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND446_14610	COG0557	exoribonuclease II activity
ND446_14615	COG1959	2 iron, 2 sulfur cluster binding
ND446_14620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND446_14625	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND446_14630	COG0330	HflC and HflK could
ND446_14635	COG0330	HflC and HflK could
ND446_14640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND446_14650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND446_14660	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND446_14665	COG0802	atpase or kinase
ND446_14670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND446_14670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND446_14675	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND446_14695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND446_14700	COG1162	GTPase activity
ND446_14705	COG0688	phosphatidylethanolamine metabolic process
ND446_14710	COG3264	Mechanosensitive ion channel
ND446_14710	COG1511	domain protein
ND446_14715	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND446_14720	COG1053	succinate dehydrogenase
ND446_14725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND446_14730	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND446_14735	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND446_14755	COG3188	usher protein
ND446_14785	COG1509	lysine 2,3-aminomutase activity
ND446_14815	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND446_14825	COG4232	protein-disulfide reductase activity
ND446_14830	COG1309	transcriptional regulator
ND446_14840	COG1301	dicarboxylic acid transport
ND446_14845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND446_14850	COG3162	membrane
ND446_14880	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND446_14885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND446_14890	COG1739	Uncharacterized protein family UPF0029
ND446_14900	COG1024	Enoyl-CoA hydratase
ND446_14900	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND446_14910	COG0543	2 iron, 2 sulfur cluster binding
ND446_14925	COG0250	Participates in transcription elongation, termination and antitermination
ND446_14940	COG0805	protein transport
ND446_14945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND446_14950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND446_14955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND446_14960	COG3165	ubiquinone biosynthetic process from chorismate
ND446_14965	COG2226	methyltransferase
ND446_14970	COG1322	Protein conserved in bacteria
ND446_14975	COG0586	Pfam SNARE associated Golgi protein
ND446_14980	COG1966	Carbon starvation protein
ND446_14995	COG0412	Dienelactone hydrolase
ND446_15000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND446_15005	COG0583	DNA-binding transcription factor activity
ND446_15010	COG0697	spore germination
ND446_15020	COG0584	glycerophosphoryl diester phosphodiesterase
ND446_15030	COG0395	ABC-type sugar transport system, permease component
ND446_15035	COG1175	transmembrane transport
ND446_15040	COG1653	transport
ND446_15075	COG0410	ABC transporter
ND446_15085	COG4177	L-phenylalanine transmembrane transporter activity
ND446_15105	COG1929	Belongs to the glycerate kinase type-1 family
ND446_15110	COG2610	gluconate transmembrane transporter activity
ND446_15115	COG3835	regulator
ND446_15125	COG2177	Part of the ABC transporter FtsEX involved in
ND446_15130	COG2884	Cell division ATP-binding protein ftsE
ND446_15135	COG0552	protein localization to endoplasmic reticulum
ND446_15135	COG0552	protein localization to endoplasmic reticulum
ND446_15140	COG0742	ribosomal rna small subunit methyltransferase
ND446_15145	COG3776	membrane
ND446_15160	COG3714	YhhN family
ND446_15175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND446_15185	COG0247	lactate metabolic process
ND446_15195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND446_15205	COG2271	Major facilitator Superfamily
ND446_15210	COG0584	glycerophosphoryl diester phosphodiesterase
ND446_15215	COG0561	phosphatase activity
ND446_15220	COG2267	carboxylic ester hydrolase activity
ND446_15225	COG1280	lysine exporter protein (LysE YggA)
ND446_15230	COG0514	ATP-dependent DNA helicase (RecQ)
ND446_15235	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND446_15240	COG2050	protein possibly involved in aromatic compounds catabolism
ND446_15260	COG5564	TIM-barrel signal transduction protein
ND446_15265	COG5441	Belongs to the UPF0261 family
ND446_15275	COG0210	DNA helicase
ND446_15280	COG1011	Hydrolase
ND446_15285	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND446_15290	COG3159	Protein conserved in bacteria
ND446_15295	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND446_15300	COG5567	small periplasmic lipoprotein
ND446_15310	COG3072	Adenylate cyclase
ND446_15315	COG0181	hydroxymethylbilane synthase activity
ND446_15320	COG1587	Uroporphyrinogen-III synthase
ND446_15325	COG2959	enzyme of heme biosynthesis
ND446_15330	COG3071	HemY protein
ND446_15380	COG2244	polysaccharide biosynthetic process
ND446_15385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND446_15390	COG0456	acetyltransferase
ND446_15395	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND446_15400	COG1088	dTDP-glucose 4,6-dehydratase activity
ND446_15405	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND446_15410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND446_15415	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND446_15420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND446_15425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND446_15430	COG3118	belongs to the thioredoxin family
ND446_15440	COG0248	Ppx GppA phosphatase
ND446_15450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND446_15465	COG3397	chitin binding
ND446_15475	COG0129	dihydroxy-acid dehydratase activity
ND446_15485	COG3978	acetolactate synthase activity
ND446_15505	COG3085	chromosome segregation
ND446_15510	COG0583	DNA-binding transcription factor activity
ND446_15590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND446_15600	COG0678	peroxiredoxin activity
ND446_15600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND446_15605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND446_15640	COG1629	transport
ND446_15645	COG0165	Argininosuccinate lyase
ND446_15650	COG0137	argininosuccinate synthase activity
ND446_15655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND446_15710	COG0527	aspartate kinase activity
ND446_15710	COG0460	homoserine dehydrogenase
ND446_15715	COG0626	cystathionine gamma-synthase activity
ND446_15720	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND446_15730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND446_15735	COG1609	Transcriptional regulator
ND446_15740	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND446_15745	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND446_15750	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND446_15755	COG1575	Belongs to the MenA family. Type 1 subfamily
ND446_15760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND446_15765	COG3074	FtsZ-dependent cytokinesis
ND446_15770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND446_15775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND446_15780	COG1494	fructose-1,6-bisphosphatase
ND446_15785	COG2814	Major facilitator Superfamily
ND446_15795	COG3152	Membrane
ND446_15810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND446_15820	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND446_15870	COG5301	cellulose 1,4-beta-cellobiosidase activity
ND446_15960	COG4695	Portal protein
ND446_16050	COG3678	ATP-independent chaperone mediated protein folding
ND446_16055	COG0745	RESPONSE REGULATOR receiver
ND446_16060	COG2205	protein histidine kinase activity
ND446_16065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND446_16070	COG1045	serine acetyltransferase
ND446_16075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND446_16080	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND446_16085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND446_16090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND446_16095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND446_16100	COG4942	peptidase
ND446_16105	COG2861	carbohydrate metabolic process
ND446_16120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND446_16125	COG0859	PFAM glycosyl transferase family 9
ND446_16130	COG0859	PFAM glycosyl transferase family 9
ND446_16135	COG1519	Transferase
ND446_16155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND446_16160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND446_16165	COG2003	Belongs to the UPF0758 family
ND446_16170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND446_16175	COG0756	dUTP diphosphatase activity
ND446_16180	COG1309	transcriptional regulator
ND446_16185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND446_16190	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND446_16195	COG1561	YicC-like family, N-terminal region
ND446_16235	COG5001	Diguanylate cyclase
ND446_16240	COG1024	Enoyl-CoA hydratase
ND446_16245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND446_16265	COG2860	membrane
ND446_16270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND446_16280	COG1758	RNA polymerase activity
ND446_16285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND446_16290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND446_16295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND446_16300	COG0786	glutamate:sodium symporter activity
ND446_16305	COG2233	PERMEase
ND446_16310	COG2982	Protein involved in outer membrane biogenesis
ND446_16315	COG0456	acetyltransferase
ND446_16330	COG1011	Hydrolase
ND446_16345	COG3852	Histidine kinase
ND446_16355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND446_16365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND446_16370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND446_16370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND446_16375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND446_16380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND446_16385	COG3084	Protein conserved in bacteria
ND446_16395	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND446_16420	COG2186	Transcriptional regulator
ND446_16425	COG1609	Transcriptional regulator
ND446_16430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND446_16440	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND446_16445	COG1129	ABC transporter
ND446_16450	COG1869	D-ribose catabolic process
ND446_16455	COG3158	transport of potassium into the cell
ND446_16460	COG0714	Associated with various cellular activities
ND446_16465	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND446_16475	COG2502	aspartate--ammonia ligase
ND446_16480	COG1522	sequence-specific DNA binding
ND446_16485	COG0716	FMN binding
ND446_16490	COG0445	tRNA wobble uridine modification
ND446_16495	COG0357	Ribosomal RNA small subunit methyltransferase G
ND446_16500	COG3312	ion transport
ND446_16505	COG0356	it plays a direct role in the translocation of protons across the membrane
ND446_16515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND446_16525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND446_16530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND446_16540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND446_16555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND446_16560	COG0573	inorganic phosphate transmembrane transporter activity
ND446_16565	COG0581	inorganic phosphate transmembrane transporter activity
ND446_16575	COG0704	Plays a role in the regulation of phosphate uptake
ND446_16580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND446_16585	COG0765	amino acid transport
ND446_16590	COG0765	amino acid transport
ND446_16595	COG2252	PERMEase
ND446_16600	COG0840	transmembrane signaling receptor activity
ND446_16610	COG3121	Chaperone
ND446_16630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND446_16635	COG0706	membrane insertase activity
ND446_16645	COG0594	ribonuclease P activity
ND446_16650	COG0230	Belongs to the bacterial ribosomal protein bL34 family