locus-tag	class	description
ND441_00010	COG0592	DNA-directed DNA polymerase activity
ND441_00020	COG0187	DNA topoisomerase II activity
ND441_00025	COG0561	phosphatase activity
ND441_00030	COG0823	Involved in the tonB-independent uptake of proteins
ND441_00035	COG5645	(Lipo)protein
ND441_00050	COG0569	domain protein
ND441_00050	COG2985	domain, Protein
ND441_00055	COG3977	Valine--pyruvate aminotransferase
ND441_00060	COG2885	chlorophyll binding
ND441_00080	COG2818	Glycosylase
ND441_00130	COG2213	PTS system mannitol-specific
ND441_00130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND441_00140	COG3722	fumarate hydratase activity
ND441_00150	COG2258	MOSC domain
ND441_00155	COG0840	transmembrane signaling receptor activity
ND441_00160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND441_00175	COG0437	4 iron, 4 sulfur cluster binding
ND441_00180	COG2864	formate dehydrogenase
ND441_00190	COG1921	L-seryl-tRNASec selenium transferase activity
ND441_00195	COG3276	selenocysteine insertion sequence binding
ND441_00200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND441_00210	COG3274	enterobacterial common antigen metabolic process
ND441_00220	COG0582	viral genome integration into host DNA
ND441_00255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND441_00260	COG2986	histidine ammonia-lyase
ND441_00280	COG2194	sulfuric ester hydrolase activity
ND441_00285	COG2197	response regulator
ND441_00290	COG3851	Histidine kinase
ND441_00295	COG2271	Major facilitator Superfamily
ND441_00305	COG0747	negative chemotaxis
ND441_00310	COG0601	transmembrane transport
ND441_00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND441_00320	COG0444	Belongs to the ABC transporter superfamily
ND441_00325	COG4608	Belongs to the ABC transporter superfamily
ND441_00330	COG2194	sulfuric ester hydrolase activity
ND441_00355	COG1215	transferase activity, transferring glycosyl groups
ND441_00360	COG1215	transferase activity, transferring glycosyl groups
ND441_00365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND441_00370	COG3118	belongs to the thioredoxin family
ND441_00370	COG0457	Tetratricopeptide repeat
ND441_00375	COG2199	diguanylate cyclase activity
ND441_00375	COG2200	EAL domain
ND441_00380	COG1301	dicarboxylic acid transport
ND441_00385	COG0612	Peptidase, M16
ND441_00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND441_00395	COG1942	4-Oxalocrotonate Tautomerase
ND441_00400	COG2200	EAL domain
ND441_00405	COG2134	cdp-diacylglycerol pyrophosphatase
ND441_00410	COG1295	ribonuclease BN
ND441_00420	COG1301	dicarboxylic acid transport
ND441_00425	COG0626	cystathionine gamma-synthase activity
ND441_00435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND441_00440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND441_00445	COG0339	signal peptide processing
ND441_00450	COG0742	ribosomal rna small subunit methyltransferase
ND441_00460	COG0589	response to stress
ND441_00470	COG0306	phosphate transporter
ND441_00475	COG2081	HI0933 family
ND441_00485	COG1247	-acetyltransferase
ND441_00495	COG1741	Belongs to the pirin family
ND441_00500	COG1609	Transcriptional regulator
ND441_00505	COG2610	gluconate transmembrane transporter activity
ND441_00510	COG3265	gluconokinase activity
ND441_00515	COG2095	MarC family integral membrane protein
ND441_00520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND441_00525	COG3275	phosphorelay sensor kinase activity
ND441_00530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND441_00535	COG1523	belongs to the glycosyl hydrolase 13 family
ND441_00540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND441_00545	COG0297	glycogen (starch) synthase activity
ND441_00550	COG0058	SHG alpha-glucan phosphorylase activity
ND441_00555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND441_00560	COG1349	DNA-binding transcription factor activity
ND441_00565	COG0705	Rhomboid family
ND441_00575	COG2909	trisaccharide binding
ND441_00580	COG0058	SHG alpha-glucan phosphorylase activity
ND441_00585	COG1640	4-alpha-glucanotransferase
ND441_00595	COG1040	competence protein
ND441_00600	COG0596	Alpha beta hydrolase
ND441_00620	COG1918	ferrous iron import across plasma membrane
ND441_00625	COG2183	response to ionizing radiation
ND441_00650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND441_00665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND441_00675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND441_00680	COG1011	Hydrolase
ND441_00690	COG0494	nUDIX hydrolase
ND441_00695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND441_00720	COG4796	Type ii and iii secretion system protein
ND441_00725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND441_00745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND441_00755	COG0180	Tryptophanyl-tRNA synthetase
ND441_00775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND441_00780	COG0402	S-adenosylhomocysteine deaminase activity
ND441_00785	COG0738	Major facilitator superfamily
ND441_00800	COG1609	Transcriptional regulator
ND441_00805	COG1486	melibiose metabolic process
ND441_00810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND441_00825	COG1289	transmembrane transporter activity
ND441_00830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND441_00835	COG1765	OsmC-like protein
ND441_00860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND441_00865	COG3954	Phosphoribulokinase
ND441_00875	COG0429	hydrolase of the alpha beta-hydrolase fold
ND441_00885	COG0859	PFAM glycosyl transferase family 9
ND441_00890	COG1216	Glycosyl transferase, family 2
ND441_00895	COG0488	(ABC) transporter
ND441_00900	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND441_00910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND441_00915	COG1047	Peptidyl-prolyl cis-trans
ND441_00925	COG0545	Peptidyl-prolyl cis-trans isomerase
ND441_00930	COG2964	Protein conserved in bacteria
ND441_00940	COG2923	Belongs to the DsrF TusC family
ND441_00945	COG2168	tRNA wobble position uridine thiolation
ND441_00950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND441_00955	COG0049	tRNA binding
ND441_00965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND441_00980	COG0051	transcription antitermination factor activity, RNA binding
ND441_00985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND441_00995	COG0089	rRNA binding
ND441_01000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND441_01005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND441_01010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND441_01020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND441_01025	COG0255	Belongs to the universal ribosomal protein uL29 family
ND441_01030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND441_01035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND441_01045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND441_01070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND441_01075	COG1841	ribosomal large subunit assembly
ND441_01080	COG0200	Binds to the 23S rRNA
ND441_01085	COG0201	protein transport
ND441_01090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND441_01095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND441_01105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND441_01115	COG0203	ribosomal protein L17
ND441_01120	COG0789	Transcriptional regulator
ND441_01125	COG3036	rescue of stalled ribosome
ND441_01130	COG1970	mechanosensitive ion channel activity
ND441_01140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND441_01140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND441_01145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND441_01150	COG0242	peptide deformylase activity
ND441_01155	COG0758	DNA mediated transformation
ND441_01160	COG2922	Belongs to the Smg family
ND441_01165	COG0551	DNA topoisomerase type I activity
ND441_01170	COG0009	L-threonylcarbamoyladenylate synthase
ND441_01180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND441_01210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND441_01215	COG3162	membrane
ND441_01220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND441_01225	COG1301	dicarboxylic acid transport
ND441_01235	COG2391	methyltransferase activity
ND441_01240	COG0425	Belongs to the sulfur carrier protein TusA family
ND441_01245	COG1086	Polysaccharide biosynthesis protein
ND441_01250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND441_01255	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND441_01260	COG2089	acid synthase
ND441_01280	COG1083	cytidylyl-transferase
ND441_01280	COG2755	lipolytic protein G-D-S-L family
ND441_01285	COG1028	Short-chain dehydrogenase reductase Sdr
ND441_01305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND441_01305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND441_01310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ND441_01330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND441_01350	COG1309	transcriptional regulator
ND441_01355	COG4232	protein-disulfide reductase activity
ND441_01365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND441_01395	COG1509	lysine 2,3-aminomutase activity
ND441_01405	COG3397	chitin binding
ND441_01425	COG3188	usher protein
ND441_01445	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND441_01450	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND441_01455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND441_01460	COG1053	succinate dehydrogenase
ND441_01465	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND441_01470	COG3264	Mechanosensitive ion channel
ND441_01470	COG1511	domain protein
ND441_01475	COG0688	phosphatidylethanolamine metabolic process
ND441_01480	COG1162	GTPase activity
ND441_01485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND441_01505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND441_01510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND441_01510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND441_01515	COG0802	atpase or kinase
ND441_01520	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND441_01530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND441_01540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND441_01545	COG0330	HflC and HflK could
ND441_01550	COG0330	HflC and HflK could
ND441_01555	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND441_01560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND441_01565	COG1959	2 iron, 2 sulfur cluster binding
ND441_01570	COG0557	exoribonuclease II activity
ND441_01575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND441_01595	COG3121	Chaperone
ND441_01600	COG3188	usher protein
ND441_01620	COG1073	alpha beta
ND441_01630	COG0360	Binds together with S18 to 16S ribosomal RNA
ND441_01635	COG2965	DNA replication, synthesis of RNA primer
ND441_01640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND441_01645	COG0359	binds to the 23S rRNA
ND441_01650	COG3061	Opacity-associated protein A
ND441_01655	COG0545	Peptidyl-prolyl cis-trans isomerase
ND441_01665	COG0737	Belongs to the 5'-nucleotidase family
ND441_01670	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND441_01675	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND441_01685	COG1253	flavin adenine dinucleotide binding
ND441_01690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND441_01695	COG0729	surface antigen
ND441_01700	COG2911	Protein conserved in bacteria
ND441_01705	COG2105	PFAM AIG2 family protein
ND441_01710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND441_01720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND441_01735	COG3423	Transcriptional regulator
ND441_01750	COG0142	geranyltranstransferase activity
ND441_01765	COG0697	spore germination
ND441_01770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND441_01775	COG0642	Histidine kinase
ND441_01780	COG0745	RESPONSE REGULATOR receiver
ND441_01785	COG2027	D-alanyl-D-alanine carboxypeptidase
ND441_01795	COG1534	Rna-binding protein
ND441_01800	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND441_01810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND441_01815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND441_01820	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND441_01840	COG0195	Participates in both transcription termination and antitermination
ND441_01850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND441_01865	COG1185	polyribonucleotide nucleotidyltransferase activity
ND441_01875	COG0513	Belongs to the DEAD box helicase family
ND441_01880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND441_01895	COG0826	peptidase U32
ND441_01900	COG0826	peptidase U32
ND441_01905	COG3154	lipid carrier protein
ND441_01910	COG3153	acetyltransferase
ND441_01915	COG2827	Endonuclease containing a URI domain
ND441_01920	COG0531	amino acid
ND441_01925	COG1982	Orn Lys Arg decarboxylase major
ND441_01935	COG3787	Belongs to the UPF0306 family
ND441_01940	COG0702	epimerase
ND441_01945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND441_01950	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND441_01955	COG3454	Phosphonate metabolism
ND441_01960	COG4778	phosphonate C-P lyase system protein PhnL
ND441_01965	COG4107	phosphonate C-P lyase system protein PhnK
ND441_01970	COG3627	carbon phosphorus lyase activity
ND441_01975	COG3626	phosphonate metabolism
ND441_01980	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND441_01985	COG3624	Phosphonate C-P lyase system protein PhnG
ND441_02005	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND441_02020	COG2927	DNA polymerase III (CHI subunit)
ND441_02025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND441_02030	COG0795	lipopolysaccharide-transporting ATPase activity
ND441_02035	COG0795	lipopolysaccharide-transporting ATPase activity
ND441_02075	COG3077	Addiction module antitoxin, RelB DinJ family
ND441_02180	COG5492	domain, Protein
ND441_02200	COG3119	arylsulfatase activity
ND441_02205	COG1349	DNA-binding transcription factor activity
ND441_02215	COG2222	sugar isomerase
ND441_02220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND441_02225	COG3715	PTS system
ND441_02230	COG3716	PTS system mannose fructose sorbose family IID component
ND441_02240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND441_02250	COG1028	Short-chain dehydrogenase reductase Sdr
ND441_02260	COG0641	radical SAM
ND441_02265	COG3119	arylsulfatase activity
ND441_02290	COG0859	PFAM glycosyl transferase family 9
ND441_02305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND441_02310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND441_02320	COG2376	Dihydroxyacetone kinase
ND441_02325	COG1461	Dihydroxyacetone kinase
ND441_02330	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND441_02330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND441_02330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND441_02370	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND441_02385	COG2823	Periplasmic or secreted lipoprotein
ND441_02395	COG4667	esterase of the alpha-beta hydrolase superfamily
ND441_02400	COG0084	hydrolase, TatD family'
ND441_02405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND441_02420	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND441_02430	COG3726	membrane protein affecting hemolysin expression
ND441_02435	COG0560	Phosphoserine phosphatase
ND441_02450	COG0488	(ABC) transporter
ND441_02475	COG0741	lytic transglycosylase activity
ND441_02480	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND441_02485	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND441_02490	COG0406	alpha-ribazole phosphatase activity
ND441_02495	COG3708	Transcriptional regulator
ND441_02495	COG2207	Transcriptional regulator
ND441_02500	COG3045	CreA protein
ND441_02505	COG0745	RESPONSE REGULATOR receiver
ND441_02540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND441_02545	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND441_02550	COG0477	Major facilitator Superfamily
ND441_02560	COG1584	GPR1 FUN34 yaaH family protein
ND441_02565	COG0443	Heat shock 70 kDa protein
ND441_02575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND441_02580	COG0583	DNA-binding transcription factor activity
ND441_02590	COG0196	riboflavin kinase activity
ND441_02600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND441_02605	COG1047	Peptidyl-prolyl cis-trans
ND441_02610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND441_02625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND441_02635	COG2966	Psort location CytoplasmicMembrane, score
ND441_02660	COG2967	ApaG domain
ND441_02665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND441_02670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND441_02680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND441_02690	COG0564	pseudouridine synthase activity
ND441_02695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND441_02700	COG0417	DNA replication proofreading
ND441_02705	COG0586	Pfam SNARE associated Golgi protein
ND441_02715	COG1178	ABC-type Fe3 transport system permease component
ND441_02720	COG4143	(ABC) transporter
ND441_02735	COG2814	Major facilitator Superfamily
ND441_02745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND441_02750	COG0473	3-isopropylmalate dehydrogenase activity
ND441_02765	COG1022	Amp-dependent synthetase and ligase
ND441_02770	COG0028	Belongs to the TPP enzyme family
ND441_02795	COG0275	rRNA processing
ND441_02800	COG3116	cell division
ND441_02805	COG0768	penicillin binding
ND441_02810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND441_02815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND441_02830	COG0772	Belongs to the SEDS family
ND441_02835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND441_02840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND441_02850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND441_02855	COG0849	cell division
ND441_02860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND441_02885	COG0494	nUDIX hydrolase
ND441_02905	COG0516	GMP reductase activity
ND441_02910	COG1459	type II secretion system
ND441_02915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND441_02920	COG4969	Belongs to the N-Me-Phe pilin family
ND441_02935	COG3725	Membrane protein required for beta-lactamase induction
ND441_02940	COG1113	amino acid transport
ND441_02945	COG2186	Transcriptional regulator
ND441_02950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND441_02955	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND441_02960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND441_02970	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND441_02975	COG3112	Uncharacterised protein family (UPF0231)
ND441_02990	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND441_03000	COG2132	Multicopper oxidase
ND441_03010	COG0288	reversible hydration of carbon dioxide
ND441_03015	COG1131	(ABC) transporter
ND441_03020	COG0842	Transport permease protein
ND441_03025	COG0726	polysaccharide deacetylase
ND441_03030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND441_03035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND441_03040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND441_03045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND441_03050	COG0617	tRNA 3'-terminal CCA addition
ND441_03065	COG1489	DNA binding
ND441_03070	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND441_03075	COG1643	Atp-dependent helicase
ND441_03080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND441_03085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND441_03095	COG0316	Belongs to the HesB IscA family
ND441_03100	COG2860	membrane
ND441_03110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND441_03115	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND441_03120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND441_03130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND441_03135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND441_03140	COG3956	TIGRFAM MazG family protein
ND441_03145	COG0504	CTP synthase activity
ND441_03155	COG0602	queuosine metabolic process
ND441_03160	COG0720	synthase
ND441_03165	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND441_03175	COG0175	sulfate reduction
ND441_03190	COG2234	aminopeptidase activity
ND441_03195	COG1648	precorrin-2 dehydrogenase activity
ND441_03195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND441_03200	COG0175	sulfate reduction
ND441_03205	COG2895	sulfate adenylyltransferase (ATP) activity
ND441_03210	COG0529	Catalyzes the synthesis of activated sulfate
ND441_03220	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND441_03230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND441_03235	COG0585	pseudouridine synthase activity
ND441_03240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND441_03250	COG1388	LysM domain
ND441_03250	COG4942	peptidase
ND441_03255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND441_03260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND441_03330	COG0784	Response regulator, receiver
ND441_03330	COG2205	protein histidine kinase activity
ND441_03350	COG0741	lytic transglycosylase activity
ND441_03480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND441_03500	COG3397	chitin binding
ND441_03510	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ND441_03555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND441_03565	COG3031	protein transport across the cell outer membrane
ND441_03590	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND441_03590	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND441_03605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND441_03610	COG2137	regulation of response to DNA damage stimulus
ND441_03615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND441_03620	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND441_03650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND441_03655	COG1238	metal cluster binding
ND441_03660	COG2918	glutathione biosynthetic process
ND441_03665	COG1854	S-ribosylhomocysteine lyase activity
ND441_03670	COG4536	flavin adenine dinucleotide binding
ND441_03675	COG4137	Cytochrome C assembly protein
ND441_03680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND441_03690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND441_03695	COG0336	Belongs to the RNA methyltransferase TrmD family
ND441_03700	COG0335	large ribosomal subunit rRNA binding
ND441_03705	COG3137	Salt-induced outer membrane protein
ND441_03710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND441_03715	COG3279	Response regulator of the LytR AlgR family
ND441_03720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND441_03725	COG1605	Chorismate mutase
ND441_03725	COG0287	Prephenate dehydrogenase
ND441_03730	COG1605	Chorismate mutase
ND441_03730	COG0077	Prephenate dehydratase
ND441_03740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND441_03745	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND441_03750	COG0564	pseudouridine synthase activity
ND441_03755	COG1496	oxidoreductase activity
ND441_03760	COG0542	response to heat
ND441_03795	COG3021	interspecies interaction between organisms
ND441_03800	COG0741	lytic transglycosylase activity
ND441_03800	COG1388	LysM domain
ND441_03810	COG2226	methyltransferase
ND441_03820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND441_03830	COG1960	acyl-CoA dehydrogenase activity
ND441_03835	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND441_03840	COG0121	glutamine amidotransferase
ND441_03845	COG3034	peptidoglycan biosynthetic process
ND441_03855	COG1805	sodium ion transport
ND441_03860	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND441_03865	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND441_03870	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND441_03880	COG1477	protein flavinylation
ND441_03885	COG2991	Protein conserved in bacteria
ND441_03895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND441_03900	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND441_03905	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND441_03910	COG1073	alpha beta
ND441_03925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND441_03960	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND441_03980	COG4126	flavin adenine dinucleotide binding
ND441_03990	COG2974	May be involved in recombination
ND441_03995	COG1940	carbohydrate kinase activity
ND441_04000	COG0419	ATPase involved in DNA repair
ND441_04005	COG0420	3'-5' exonuclease activity
ND441_04010	COG0745	RESPONSE REGULATOR receiver
ND441_04015	COG5002	protein histidine kinase activity
ND441_04030	COG1113	amino acid transport
ND441_04035	COG0366	Alpha amylase catalytic
ND441_04040	COG0300	oxidoreductase activity
ND441_04045	COG0450	alkyl hydroperoxide reductase
ND441_04050	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND441_04065	COG1862	Preprotein translocase
ND441_04070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND441_04075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND441_04080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND441_04085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND441_04085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND441_04090	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND441_04100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND441_04105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND441_04110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND441_04115	COG0142	geranyltranstransferase activity
ND441_04150	COG0693	protein deglycase activity
ND441_04155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND441_04160	COG1666	GTP binding
ND441_04165	COG2814	Major facilitator Superfamily
ND441_04175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND441_04180	COG1845	cytochrome c oxidase, subunit III
ND441_04185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND441_04190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND441_04200	COG2223	nitrite transmembrane transporter activity
ND441_04205	COG3056	Lipoprotein
ND441_04210	COG0271	Belongs to the BolA IbaG family
ND441_04220	COG0740	serine-type endopeptidase activity
ND441_04225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND441_04230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND441_04235	COG0776	regulation of translation
ND441_04240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND441_04245	COG1555	photosystem II stabilization
ND441_04250	COG0824	Thioesterase
ND441_04255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND441_04260	COG4533	DNA binding
ND441_04275	COG1522	sequence-specific DNA binding
ND441_04280	COG1132	(ABC) transporter
ND441_04285	COG1132	(ABC) transporter
ND441_04290	COG0347	Belongs to the P(II) protein family
ND441_04295	COG0004	ammonium transporteR
ND441_04300	COG1946	Acyl-CoA thioesterase
ND441_04305	COG3695	enzyme binding
ND441_04330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND441_04335	COG0254	rRNA binding
ND441_04340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND441_04345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND441_04350	COG1309	transcriptional regulator
ND441_04355	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND441_04360	COG1196	nuclear chromosome segregation
ND441_04360	COG3264	Mechanosensitive ion channel
ND441_04375	COG2832	Protein of unknown function (DUF454)
ND441_04380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND441_04420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND441_04425	COG0326	Molecular chaperone. Has ATPase activity
ND441_04440	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND441_04445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND441_04450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND441_04450	COG4651	solute:proton antiporter activity
ND441_04455	COG0737	Belongs to the 5'-nucleotidase family
ND441_04460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND441_04465	COG3735	TraB family
ND441_04470	COG2217	Heavy metal translocating P-type atpase
ND441_04475	COG0789	Transcriptional regulator
ND441_04480	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND441_04485	COG0330	HflC and HflK could
ND441_04490	COG3118	belongs to the thioredoxin family
ND441_04495	COG0300	oxidoreductase activity
ND441_04500	COG2755	lipolytic protein G-D-S-L family
ND441_04505	COG4181	ATPase activity
ND441_04510	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND441_04515	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND441_04520	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND441_04525	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND441_04530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND441_04555	COG3188	usher protein
ND441_04560	COG3121	Chaperone
ND441_04590	COG2501	S4 domain
ND441_04595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND441_04610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND441_04615	COG1393	Belongs to the ArsC family
ND441_04625	COG1022	Amp-dependent synthetase and ligase
ND441_04650	COG3038	cytochrome b561
ND441_04680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND441_04690	COG1215	transferase activity, transferring glycosyl groups
ND441_04710	COG3250	beta-galactosidase activity
ND441_04725	COG1309	transcriptional regulator
ND441_04755	COG2197	response regulator
ND441_04760	COG1278	Cold shock
ND441_04780	COG3706	GGDEF domain
ND441_04790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND441_04800	COG2921	Belongs to the UPF0250 family
ND441_04805	COG1686	Belongs to the peptidase S11 family
ND441_04810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND441_04815	COG0772	Belongs to the SEDS family
ND441_04820	COG0768	penicillin binding
ND441_04825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND441_04830	COG0799	negative regulation of ribosome biogenesis
ND441_04835	COG0582	viral genome integration into host DNA
ND441_04895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND441_04960	COG0305	Participates in initiation and elongation during chromosome replication
ND441_04985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ND441_05060	COG0616	signal peptide processing
ND441_05100	COG4386	tail sheath protein
ND441_05140	COG3299	homolog of phage Mu protein gp47
ND441_05155	COG5301	cellulose 1,4-beta-cellobiosidase activity
ND441_05165	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND441_05170	COG1466	dna polymerase III delta subunit
ND441_05175	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND441_05185	COG2888	peptidyl-tyrosine sulfation
ND441_05190	COG1126	abc transporter atp-binding protein
ND441_05195	COG0765	amino acid transport
ND441_05200	COG0765	amino acid transport
ND441_05210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND441_05215	COG4535	Mg2 and Co2 transporter CorC
ND441_05220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND441_05225	COG1702	phosphate starvation-inducible protein PhoH
ND441_05230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND441_05235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND441_05270	COG0367	asparagine synthase
ND441_05275	COG0647	UMP catabolic process
ND441_05280	COG1846	Transcriptional regulator
ND441_05280	COG1940	carbohydrate kinase activity
ND441_05285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND441_05295	COG1263	PTS System
ND441_05295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND441_05295	COG2190	(PTS) system
ND441_05320	COG0735	belongs to the Fur family
ND441_05330	COG0840	transmembrane signaling receptor activity
ND441_05340	COG0596	Alpha beta hydrolase
ND441_05345	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND441_05350	COG0033	Phosphoglucomutase
ND441_05360	COG0745	RESPONSE REGULATOR receiver
ND441_05365	COG2205	protein histidine kinase activity
ND441_05370	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND441_05375	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND441_05395	COG3272	Protein of unknown function (DUF1722)
ND441_05400	COG0415	Belongs to the DNA photolyase family
ND441_05405	COG5212	phosphodiesterase
ND441_05410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND441_05415	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND441_05420	COG1984	allophanate hydrolase subunit 2
ND441_05425	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND441_05460	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND441_05465	COG1053	succinate dehydrogenase
ND441_05470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND441_05475	COG0567	Dehydrogenase, E1 component
ND441_05480	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND441_05485	COG0045	succinate-CoA ligase (ADP-forming) activity
ND441_05490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND441_05495	COG0737	Belongs to the 5'-nucleotidase family
ND441_05500	COG1271	oxidase subunit
ND441_05505	COG1294	oxidase, subunit
ND441_05510	COG4890	Cyd operon protein YbgT
ND441_05515	COG3790	cyd operon protein YbgE
ND441_05520	COG0824	Thioesterase
ND441_05525	COG0811	peptide transport
ND441_05530	COG0848	biopolymer transport protein
ND441_05535	COG3064	Membrane
ND441_05535	COG3064	Membrane
ND441_05540	COG0823	Involved in the tonB-independent uptake of proteins
ND441_05545	COG2885	chlorophyll binding
ND441_05550	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND441_05590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND441_05600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND441_05600	COG2205	protein histidine kinase activity
ND441_05610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND441_05615	COG0588	phosphoglycerate mutase activity
ND441_05625	COG2017	converts alpha-aldose to the beta-anomer
ND441_05635	COG1085	galactose-1-phosphate uridylyltransferase
ND441_05640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND441_05655	COG2005	Transcriptional regulator
ND441_05655	COG3585	molybdate ion transport
ND441_05665	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND441_05670	COG4149	molybdate abc transporter
ND441_05680	COG0561	phosphatase activity
ND441_05685	COG2706	6-phosphogluconolactonase activity
ND441_05700	COG0156	8-amino-7-oxononanoate synthase activity
ND441_05705	COG2226	methyltransferase
ND441_05720	COG0556	nucleotide-excision repair
ND441_05725	COG4628	conserved protein (DUF2132)
ND441_05740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND441_05745	COG1120	ATPase activity
ND441_05750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND441_05755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND441_05765	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND441_05770	COG0314	molybdopterin synthase activity
ND441_05775	COG0670	Belongs to the BI1 family
ND441_05780	COG0842	Transport permease protein
ND441_05785	COG0842	Transport permease protein
ND441_05790	COG1131	(ABC) transporter
ND441_05795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND441_05800	COG1309	transcriptional regulator
ND441_05805	COG0513	Belongs to the DEAD box helicase family
ND441_05810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND441_05820	COG1686	Belongs to the peptidase S11 family
ND441_05825	COG0277	FAD linked oxidase domain protein
ND441_05845	COG2261	transglycosylase associated protein
ND441_05855	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND441_05865	COG3639	organic phosphonate transmembrane transporter activity
ND441_05870	COG4807	Protein conserved in bacteria
ND441_05875	COG2897	thiosulfate sulfurtransferase activity
ND441_05880	COG1732	Glycine betaine
ND441_05885	COG1174	glycine betaine transport
ND441_05890	COG1125	glycine betaine transport
ND441_05895	COG1174	glycine betaine transport
ND441_05900	COG0531	amino acid
ND441_05905	COG1982	Orn Lys Arg decarboxylase major
ND441_05915	COG0697	spore germination
ND441_05930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND441_05935	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND441_05940	COG1126	abc transporter atp-binding protein
ND441_05945	COG0765	amino acid transport
ND441_05950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND441_05970	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND441_05975	COG2239	Acts as a magnesium transporter
ND441_05980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND441_05985	COG0488	(ABC) transporter
ND441_05990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND441_05995	COG0303	'Molybdopterin
ND441_06015	COG0583	DNA-binding transcription factor activity
ND441_06020	COG0477	Major facilitator Superfamily
ND441_06025	COG0302	gtp cyclohydrolase
ND441_06030	COG2311	Membrane
ND441_06055	COG2949	membrane
ND441_06060	COG0281	malic enzyme
ND441_06070	COG0583	DNA-binding transcription factor activity
ND441_06080	COG1346	cytolysis
ND441_06085	COG1380	Effector of murein hydrolase LrgA
ND441_06095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND441_06095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND441_06100	COG0489	protein tyrosine kinase activity
ND441_06105	COG0572	uridine kinase
ND441_06110	COG0717	Belongs to the dCTP deaminase family
ND441_06115	COG2982	Protein involved in outer membrane biogenesis
ND441_06120	COG3069	C4-dicarboxylate transmembrane transporter activity
ND441_06125	COG1253	flavin adenine dinucleotide binding
ND441_06130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND441_06135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND441_06140	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND441_06150	COG0140	phosphoribosyl-ATP diphosphatase activity
ND441_06150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND441_06160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND441_06170	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND441_06170	COG0131	Imidazoleglycerol-phosphate dehydratase
ND441_06175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND441_06180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND441_06195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND441_06200	COG0625	glutathione transferase activity
ND441_06215	COG0626	cystathionine gamma-synthase activity
ND441_06225	COG1686	Belongs to the peptidase S11 family
ND441_06230	COG1760	l-serine dehydratase
ND441_06235	COG0814	amino acid
ND441_06240	COG1349	DNA-binding transcription factor activity
ND441_06250	COG0671	phosphoesterase, PA-phosphatase related
ND441_06260	COG0569	domain protein
ND441_06260	COG2985	domain, Protein
ND441_06280	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND441_06285	COG3842	ATPase activity
ND441_06290	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND441_06295	COG1177	transmembrane transport
ND441_06310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND441_06315	COG4160	amino acid transport
ND441_06320	COG4215	(ABC) transporter
ND441_06325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND441_06330	COG1126	abc transporter atp-binding protein
ND441_06340	COG0393	Putative heavy-metal-binding
ND441_06345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND441_06350	COG0702	epimerase
ND441_06355	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND441_06360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND441_06365	COG1151	hydroxylamine reductase activity
ND441_06370	COG2431	L-lysine efflux transmembrane transporter activity
ND441_06375	COG3593	DNA synthesis involved in DNA repair
ND441_06380	COG2990	Protein conserved in bacteria
ND441_06385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND441_06395	COG1278	Cold shock
ND441_06400	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND441_06405	COG0542	response to heat
ND441_06410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND441_06420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND441_06430	COG0492	ferredoxin-NADP+ reductase activity
ND441_06435	COG1522	sequence-specific DNA binding
ND441_06440	COG1674	ftsk spoiiie
ND441_06440	COG3107	peptidoglycan biosynthetic process
ND441_06445	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND441_06450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND441_06455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND441_06460	COG2814	Major facilitator Superfamily
ND441_06465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND441_06470	COG1882	Formate acetyltransferase
ND441_06475	COG2116	formate transmembrane transporter activity
ND441_06480	COG1944	ATP diphosphatase activity
ND441_06485	COG0252	asparaginase activity
ND441_06495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND441_06505	COG0539	negative regulation of cytoplasmic translation
ND441_06515	COG0658	competence protein
ND441_06515	COG2333	competence protein COMEC
ND441_06525	COG1663	tetraacyldisaccharide 4'-kinase activity
ND441_06530	COG5383	Protein conserved in bacteria
ND441_06540	COG1278	Cold shock
ND441_06545	COG2835	tetraacyldisaccharide 4'-kinase activity
ND441_06550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND441_06555	COG3173	Aminoglycoside phosphotransferase
ND441_06560	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND441_06565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND441_06570	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND441_06580	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND441_06585	COG2989	Protein conserved in bacteria
ND441_06590	COG3108	Peptidase M15
ND441_06595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND441_06600	COG1448	Aminotransferase
ND441_06615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND441_06620	COG0308	aminopeptidase N
ND441_06625	COG0167	dihydroorotate dehydrogenase activity
ND441_06635	COG3217	Mosc domain protein beta barrel domain protein
ND441_06635	COG0633	Ferredoxin
ND441_06640	COG0116	Belongs to the methyltransferase superfamily
ND441_06640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND441_06645	COG0488	(ABC) transporter
ND441_06650	COG2995	paraquat-inducible protein a
ND441_06655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND441_06655	COG3008	intermembrane lipid transfer
ND441_06660	COG3009	Protein conserved in bacteria
ND441_06665	COG3130	regulation of translation
ND441_06670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND441_06675	COG1067	ATP-dependent peptidase activity
ND441_06680	COG3120	sequence-specific DNA binding
ND441_06690	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND441_06695	COG3070	regulator of competence-specific genes
ND441_06700	COG1289	transmembrane transporter activity
ND441_06705	COG3304	Inner membrane component domain
ND441_06710	COG0210	DNA helicase
ND441_06715	COG1803	Methylglyoxal synthase
ND441_06725	COG1832	CoA-binding protein
ND441_06730	COG3785	DNA binding
ND441_06735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND441_06740	COG1254	Belongs to the acylphosphatase family
ND441_06745	COG2920	part of a sulfur-relay system
ND441_06755	COG0288	reversible hydration of carbon dioxide
ND441_06775	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND441_06780	COG2943	transferase activity, transferring hexosyl groups
ND441_06795	COG0675	Transposase, IS605 OrfB family
ND441_06810	COG1560	Kdo2-lipid A biosynthetic process
ND441_06820	COG0628	permease
ND441_06845	COG0418	dihydroorotase activity
ND441_06850	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND441_06860	COG1530	ribonuclease E activity
ND441_06865	COG0564	pseudouridine synthase activity
ND441_06870	COG0424	maF-like protein
ND441_06875	COG1399	metal-binding, possibly nucleic acid-binding protein
ND441_06880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND441_06890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND441_06895	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND441_06905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND441_06910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND441_06915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND441_06920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND441_06925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND441_06930	COG0470	DNA polymerase III
ND441_06935	COG0084	hydrolase, TatD family'
ND441_06940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND441_06940	COG1263	PTS System
ND441_06945	COG0537	adenosine 5'-monophosphoramidase activity
ND441_06950	COG5633	Lipoprotein
ND441_06955	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND441_06970	COG3150	esterase
ND441_06975	COG1252	NADH dehydrogenase
ND441_06980	COG3134	Outer membrane lipoprotein
ND441_06985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND441_06990	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND441_07000	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND441_07020	COG2850	peptidyl-arginine hydroxylation
ND441_07025	COG2205	protein histidine kinase activity
ND441_07030	COG0745	RESPONSE REGULATOR receiver
ND441_07040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND441_07045	COG2915	High frequency lysogenization protein hflD homolog
ND441_07050	COG0482	sulfurtransferase activity
ND441_07060	COG1187	pseudouridine synthase activity
ND441_07065	COG0538	isocitrate dehydrogenase activity
ND441_07070	COG2771	luxR family
ND441_07075	COG3916	Acyl-homoserine-lactone synthase
ND441_07080	COG2723	6-phospho-beta-galactosidase activity
ND441_07090	COG0339	signal peptide processing
ND441_07095	COG0840	transmembrane signaling receptor activity
ND441_07120	COG0675	Transposase, IS605 OrfB family
ND441_07130	COG4565	transcriptional regulatory protein
ND441_07135	COG3290	protein histidine kinase activity
ND441_07140	COG0471	metal ion transport
ND441_07180	COG4977	sequence-specific DNA binding
ND441_07185	COG1702	phosphate starvation-inducible protein PhoH
ND441_07190	COG0387	Pfam Sodium calcium exchanger
ND441_07195	COG2375	cellular response to nickel ion
ND441_07200	COG3850	Histidine kinase
ND441_07210	COG1294	oxidase, subunit
ND441_07215	COG1271	oxidase subunit
ND441_07220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND441_07225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND441_07230	COG3138	arginine N-succinyltransferase
ND441_07240	COG3724	N-succinylarginine dihydrolase activity
ND441_07260	COG1228	amidohydrolase
ND441_07270	COG0402	S-adenosylhomocysteine deaminase activity
ND441_07290	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND441_07295	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND441_07300	COG3383	formate dehydrogenase (NAD+) activity
ND441_07305	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND441_07310	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND441_07320	COG3260	NADH ubiquinone oxidoreductase 20
ND441_07325	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND441_07330	COG3261	NADH dehydrogenase
ND441_07330	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND441_07335	COG0650	Formate hydrogenlyase subunit 4
ND441_07340	COG0651	ATP synthesis coupled electron transport
ND441_07345	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND441_07355	COG0375	protein maturation
ND441_07360	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND441_07365	COG0298	carbon dioxide binding
ND441_07370	COG0409	Hydrogenase expression formation protein
ND441_07375	COG0309	Hydrogenase expression formation protein (HypE)
ND441_07410	COG3708	Transcriptional regulator
ND441_07410	COG2207	Transcriptional regulator
ND441_07415	COG0012	GTP binding
ND441_07425	COG0193	aminoacyl-tRNA hydrolase activity
ND441_07435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND441_07445	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND441_07450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND441_07455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND441_07460	COG2890	protein-(glutamine-N5) methyltransferase activity
ND441_07475	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND441_07480	COG0659	secondary active sulfate transmembrane transporter activity
ND441_07485	COG3706	GGDEF domain
ND441_07510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND441_07520	COG3381	protein complex oligomerization
ND441_07540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND441_07550	COG0673	inositol 2-dehydrogenase activity
ND441_07555	COG0728	peptidoglycan biosynthetic process
ND441_07580	COG3102	Protein conserved in bacteria
ND441_07585	COG3142	Participates in the control of copper homeostasis
ND441_07600	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND441_07605	COG1801	Protein of unknown function DUF72
ND441_07615	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND441_07620	COG0494	nUDIX hydrolase
ND441_07630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND441_07640	COG2255	four-way junction helicase activity
ND441_07645	COG3104	oligopeptide transport
ND441_07650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND441_07655	COG1121	(ABC) transporter
ND441_07660	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND441_07665	COG0739	heme binding
ND441_07670	COG1560	Kdo2-lipid A biosynthetic process
ND441_07675	COG0469	pyruvate kinase activity
ND441_07680	COG1737	Transcriptional regulator
ND441_07685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND441_07690	COG0800	Aldolase
ND441_07700	COG2076	Multidrug Resistance protein
ND441_07705	COG0251	oxidation-reduction process
ND441_07710	COG1199	ATP-dependent helicase activity
ND441_07715	COG1214	PFAM Peptidase M22, glycoprotease
ND441_07720	COG3065	identical protein binding
ND441_07725	COG0318	PFAM AMP-dependent synthetase and ligase
ND441_07730	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND441_07735	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND441_07740	COG2894	cell division
ND441_07745	COG0850	regulation of cytokinetic process
ND441_07750	COG3100	YcgL domain-containing protein
ND441_07755	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND441_07760	COG2983	Belongs to the UPF0260 family
ND441_07780	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND441_07790	COG2719	SpoVR family
ND441_07795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND441_07800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND441_07805	COG2814	Major facilitator Superfamily
ND441_07815	COG2200	EAL domain
ND441_07815	COG2202	Pas domain
ND441_07815	COG2199	diguanylate cyclase activity
ND441_07835	COG2718	Belongs to the UPF0229 family
ND441_07840	COG2766	serine protein kinase
ND441_07850	COG3713	MltA-interacting MipA family protein
ND441_07855	COG2194	sulfuric ester hydrolase activity
ND441_07870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND441_07875	COG3139	Protein of unknown function (DUF1315)
ND441_07880	COG1335	isochorismatase
ND441_07885	COG0252	asparaginase activity
ND441_07890	COG0616	signal peptide processing
ND441_07895	COG0778	Nitroreductase
ND441_07905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND441_07915	COG0494	nUDIX hydrolase
ND441_07920	COG0708	Exodeoxyribonuclease III
ND441_07950	COG0788	formyltetrahydrofolate deformylase activity
ND441_07960	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND441_07965	COG0745	RESPONSE REGULATOR receiver
ND441_07985	COG1454	alcohol dehydrogenase
ND441_07985	COG1012	belongs to the aldehyde dehydrogenase family
ND441_07995	COG2095	MarC family integral membrane protein
ND441_08000	COG4166	transmembrane transport
ND441_08015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND441_08030	COG3099	Belongs to the UPF0263 family
ND441_08035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND441_08055	COG2350	Protein conserved in bacteria
ND441_08070	COG3710	Transcriptional regulator
ND441_08105	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND441_08130	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND441_08135	COG3047	cAMP biosynthetic process
ND441_08150	COG0133	tryptophan synthase activity
ND441_08155	COG0134	indole-3-glycerol-phosphate synthase activity
ND441_08155	COG0135	phosphoribosylanthranilate isomerase activity
ND441_08165	COG0512	Glutamine amidotransferase of anthranilate synthase
ND441_08175	COG0613	PHP domain protein
ND441_08180	COG0009	L-threonylcarbamoyladenylate synthase
ND441_08200	COG1187	pseudouridine synthase activity
ND441_08210	COG1028	Short-chain dehydrogenase reductase Sdr
ND441_08215	COG0616	signal peptide processing
ND441_08230	COG0583	DNA-binding transcription factor activity
ND441_08245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND441_08255	COG0671	phosphoesterase, PA-phosphatase related
ND441_08260	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND441_08265	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND441_08285	COG0023	Translation Initiation Factor
ND441_08295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND441_08300	COG5002	protein histidine kinase activity
ND441_08300	COG5001	Diguanylate cyclase
ND441_08300	COG3447	MASE1 domain protein
ND441_08305	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND441_08310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND441_08320	COG4659	FMN binding
ND441_08330	COG3708	Transcriptional regulator
ND441_08330	COG2207	Transcriptional regulator
ND441_08345	COG4657	Part of a membrane complex involved in electron transport
ND441_08355	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND441_08365	COG0673	inositol 2-dehydrogenase activity
ND441_08370	COG0385	Bile acid
ND441_08375	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND441_08380	COG5339	Protein conserved in bacteria
ND441_08385	COG1482	cell wall glycoprotein biosynthetic process
ND441_08390	COG0114	fumarate hydratase activity
ND441_08400	COG1940	carbohydrate kinase activity
ND441_08405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND441_08425	COG1742	UPF0060 membrane protein
ND441_08430	COG4221	oxidoreductase activity
ND441_08435	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND441_08455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND441_08495	COG1011	Hydrolase
ND441_08505	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND441_08510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND441_08515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND441_08520	COG0589	response to stress
ND441_08550	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND441_08555	COG3623	hexulose-6-phosphate isomerase
ND441_08560	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND441_08565	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND441_08575	COG0531	amino acid
ND441_08585	COG0745	RESPONSE REGULATOR receiver
ND441_08590	COG2205	protein histidine kinase activity
ND441_08605	COG2207	Transcriptional regulator
ND441_08610	COG1881	PFAM PEBP family protein
ND441_08620	COG3591	Belongs to the peptidase S1B family
ND441_08625	COG1643	Atp-dependent helicase
ND441_08630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND441_08635	COG3784	Protein of unknown function (DUF1318)
ND441_08650	COG2911	Protein conserved in bacteria
ND441_08655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND441_08660	COG3187	Heat shock protein
ND441_08665	COG3042	response to heat
ND441_08670	COG1285	pathogenesis
ND441_08680	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND441_08680	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND441_08680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND441_08680	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND441_08695	COG4166	transmembrane transport
ND441_08700	COG2866	Carboxypeptidase
ND441_08705	COG4948	Mandelate Racemase Muconate Lactonizing
ND441_08710	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND441_08720	COG5642	Protein of unknown function (DUF2384)
ND441_08725	COG5654	RES domain protein
ND441_08730	COG3768	UPF0283 membrane protein
ND441_08735	COG3106	COG3106 Predicted ATPase
ND441_08745	COG1983	PspC domain protein
ND441_08755	COG1842	Phage shock protein A
ND441_08760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND441_08775	COG4166	transmembrane transport
ND441_08785	COG4171	peptide transport system, permease
ND441_08790	COG4172	Belongs to the ABC transporter superfamily
ND441_08795	COG4172	Belongs to the ABC transporter superfamily
ND441_08805	COG3104	oligopeptide transport
ND441_08815	COG0484	heat shock protein binding
ND441_08860	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND441_08865	COG3133	Outer membrane lipoprotein
ND441_08870	COG1846	Transcriptional regulator
ND441_08880	COG4989	oxidoreductase activity
ND441_08885	COG3313	Fe-S protein
ND441_08890	COG2194	sulfuric ester hydrolase activity
ND441_08895	COG1309	transcriptional regulator
ND441_08900	COG1902	pentaerythritol trinitrate reductase activity
ND441_08915	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND441_08920	COG0791	NLP P60 protein
ND441_08925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND441_08935	COG1609	Transcriptional regulator
ND441_08940	COG0583	DNA-binding transcription factor activity
ND441_08945	COG2814	Major facilitator Superfamily
ND441_08950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND441_08955	COG0307	riboflavin synthase, alpha
ND441_08990	COG1376	ErfK ybiS ycfS ynhG family protein
ND441_08990	COG1388	LysM domain
ND441_08995	COG2166	iron-sulfur cluster assembly
ND441_09005	COG0719	Fe-S assembly protein
ND441_09010	COG0396	ATPase activity
ND441_09015	COG0719	Fe-S assembly protein
ND441_09020	COG0316	Belongs to the HesB IscA family
ND441_09025	COG2050	protein possibly involved in aromatic compounds catabolism
ND441_09030	COG0247	lactate metabolic process
ND441_09030	COG0277	FAD linked oxidase domain protein
ND441_09035	COG0628	permease
ND441_09045	COG0574	Belongs to the PEP-utilizing enzyme family
ND441_09045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND441_09050	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND441_09055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND441_09065	COG4771	TonB-dependent receptor
ND441_09070	COG3720	iron ion transport
ND441_09075	COG4558	Periplasmic binding protein
ND441_09080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND441_09085	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND441_09095	COG0095	Lipoate-protein ligase
ND441_09100	COG0791	NLP P60 protein
ND441_09105	COG2076	Multidrug Resistance protein
ND441_09110	COG2076	Multidrug Resistance protein
ND441_09115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND441_09130	COG0463	Glycosyl transferase, family 2
ND441_09135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND441_09145	COG4139	cobalamin transport
ND441_09190	COG2184	nucleotidyltransferase activity
ND441_09205	COG2314	TM2 domain
ND441_09210	COG0776	regulation of translation
ND441_09280	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND441_09285	COG1121	(ABC) transporter
ND441_09290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND441_09295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND441_09300	COG3001	Fructosamine kinase
ND441_09310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND441_09315	COG1988	membrane-bound metal-dependent
ND441_09320	COG1823	symporter activity
ND441_09325	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND441_09335	COG2814	Major facilitator Superfamily
ND441_09345	COG0501	Belongs to the peptidase M48B family
ND441_09350	COG0793	Belongs to the peptidase S41A family
ND441_09360	COG1956	GAF domain-containing protein
ND441_09365	COG2995	paraquat-inducible protein a
ND441_09370	COG3008	intermembrane lipid transfer
ND441_09375	COG2203	Gaf domain
ND441_09375	COG4251	negative regulation of phosphorylation
ND441_09375	COG5001	Diguanylate cyclase
ND441_09375	COG3706	GGDEF domain
ND441_09585	COG3772	lysozyme
ND441_09635	COG1178	ABC-type Fe3 transport system permease component
ND441_09635	COG1674	ftsk spoiiie
ND441_09755	COG1276	copper resistance
ND441_09760	COG2372	response to copper ion
ND441_09765	COG1528	Iron-storage protein
ND441_09785	COG1770	oligopeptidase
ND441_09795	COG3097	Belongs to the UPF0267 family
ND441_09800	COG3141	response to X-ray
ND441_09805	COG0513	Belongs to the DEAD box helicase family
ND441_09825	COG0494	nUDIX hydrolase
ND441_09830	COG1760	l-serine dehydratase
ND441_09835	COG1253	flavin adenine dinucleotide binding
ND441_09840	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND441_09840	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND441_09845	COG3715	PTS system
ND441_09850	COG3716	PTS system mannose fructose sorbose family IID component
ND441_09855	COG4811	Protein of unknown function (DUF986)
ND441_09860	COG1971	Probably functions as a manganese efflux pump
ND441_09880	COG1960	acyl-CoA dehydrogenase activity
ND441_09890	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND441_09920	COG2226	methyltransferase
ND441_09925	COG0768	penicillin binding
ND441_09930	COG1496	oxidoreductase activity
ND441_09950	COG1113	amino acid transport
ND441_09985	COG2207	Transcriptional regulator
ND441_10005	COG1132	(ABC) transporter
ND441_10015	COG5001	Diguanylate cyclase
ND441_10015	COG2203	Gaf domain
ND441_10015	COG3706	GGDEF domain
ND441_10015	COG4251	negative regulation of phosphorylation
ND441_10035	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND441_10055	COG1278	Cold shock
ND441_10060	COG1278	Cold shock
ND441_10065	COG1278	Cold shock
ND441_10080	COG1917	Cupin 2, conserved barrel domain protein
ND441_10080	COG2169	Transcriptional regulator
ND441_10085	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND441_10090	COG2723	6-phospho-beta-galactosidase activity
ND441_10095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND441_10100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND441_10105	COG1187	pseudouridine synthase activity
ND441_10115	COG3122	Protein conserved in bacteria
ND441_10120	COG1757	Na H antiporter
ND441_10135	COG2235	arginine
ND441_10150	COG0076	glutamate decarboxylase activity
ND441_10155	COG0531	amino acid
ND441_10190	COG2153	protein acetylation
ND441_10195	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND441_10225	COG0840	transmembrane signaling receptor activity
ND441_10230	COG2801	Transposase and inactivated derivatives
ND441_10250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND441_10255	COG0322	excinuclease ABC activity
ND441_10260	COG2197	response regulator
ND441_10285	COG1113	amino acid transport
ND441_10295	COG0531	amino acid
ND441_10300	COG3710	Transcriptional regulator
ND441_10305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND441_10310	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND441_10310	COG0506	proline dehydrogenase activity
ND441_10310	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND441_10315	COG1126	abc transporter atp-binding protein
ND441_10320	COG0765	amino acid transport
ND441_10325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND441_10330	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND441_10340	COG1191	sigma factor activity
ND441_10380	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND441_10385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND441_10400	COG1677	Flagellar hook-basal body complex protein FliE
ND441_10410	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND441_10415	COG1317	bacterial-type flagellum organization
ND441_10420	COG1157	protein secretion by the type III secretion system
ND441_10435	COG1580	Controls the rotational direction of flagella during chemotaxis
ND441_10515	COG1558	bacterial-type flagellum-dependent cell motility
ND441_10520	COG1815	bacterial-type flagellum-dependent cell motility
ND441_10530	COG2747	anti-sigma28 factor FlgM
ND441_10535	COG3418	PFAM FlgN family protein
ND441_10545	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND441_10550	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND441_10555	COG4935	Belongs to the peptidase S8 family
ND441_10555	COG1404	Belongs to the peptidase S8 family
ND441_10560	COG2197	response regulator
ND441_10575	COG3188	usher protein
ND441_10580	COG3121	Chaperone
ND441_10590	COG3539	Fimbrial protein
ND441_10620	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND441_10625	COG0745	RESPONSE REGULATOR receiver
ND441_10635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND441_10640	COG0840	transmembrane signaling receptor activity
ND441_10645	COG0840	transmembrane signaling receptor activity
ND441_10650	COG0835	chemotaxis
ND441_10655	COG0643	Histidine kinase
ND441_10655	COG2198	Histidine kinase
ND441_10660	COG1360	Flagellar Motor Protein
ND441_10680	COG0589	response to stress
ND441_10685	COG1285	pathogenesis
ND441_10690	COG0840	transmembrane signaling receptor activity
ND441_10710	COG1609	Transcriptional regulator
ND441_10720	COG3321	synthase
ND441_10720	COG1028	Short-chain dehydrogenase reductase Sdr
ND441_10720	COG0604	alcohol dehydrogenase
ND441_10755	COG0582	viral genome integration into host DNA
ND441_10770	COG3423	Transcriptional regulator
ND441_10805	COG3451	type IV secretory pathway VirB4
ND441_10825	COG3736	Type IV secretory pathway, component VirB8
ND441_10840	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ND441_10855	COG4227	nucleotidyltransferase activity
ND441_10915	COG0471	metal ion transport
ND441_10930	COG3051	citrate lyase alpha subunit
ND441_10935	COG2301	Belongs to the HpcH HpaI aldolase family
ND441_10940	COG3052	prosthetic group binding
ND441_10945	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND441_10950	COG3290	protein histidine kinase activity
ND441_10955	COG4565	transcriptional regulatory protein
ND441_10970	COG2271	Major facilitator Superfamily
ND441_10975	COG1840	ABC-type Fe3 transport system, periplasmic component
ND441_10985	COG3842	ATPase activity
ND441_11005	COG1289	transmembrane transporter activity
ND441_11015	COG2925	Exonuclease
ND441_11020	COG0531	amino acid
ND441_11025	COG4771	TonB-dependent receptor
ND441_11035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND441_11045	COG0833	amino acid
ND441_11050	COG0583	DNA-binding transcription factor activity
ND441_11060	COG2855	membrane
ND441_11065	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND441_11070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND441_11070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND441_11070	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND441_11075	COG1105	Belongs to the carbohydrate kinase PfkB family
ND441_11090	COG3005	denitrification pathway
ND441_11095	COG0243	molybdopterin cofactor binding
ND441_11115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND441_11125	COG0246	Mannitol dehydrogenase
ND441_11135	COG0523	cobalamin synthesis protein
ND441_11140	COG0671	phosphoesterase, PA-phosphatase related
ND441_11145	COG0791	NLP P60 protein
ND441_11150	COG2200	EAL domain
ND441_11155	COG4166	transmembrane transport
ND441_11160	COG4174	ABC transporter (Permease)
ND441_11165	COG4239	(ABC) transporter, permease
ND441_11170	COG4172	Belongs to the ABC transporter superfamily
ND441_11180	COG2814	Major facilitator Superfamily
ND441_11185	COG1187	pseudouridine synthase activity
ND441_11190	COG1061	Type III restriction enzyme res subunit
ND441_11205	COG3082	Protein of unknown function (DUF1414)
ND441_11210	COG3083	sulfuric ester hydrolase activity
ND441_11235	COG3778	Protein conserved in bacteria
ND441_11240	COG3299	homolog of phage Mu protein gp47
ND441_11285	COG4386	tail sheath protein
ND441_11335	COG4626	Terminase
ND441_11335	COG1802	Transcriptional regulator
ND441_11360	COG1876	peptidase activity
ND441_11390	COG2815	serine threonine protein kinase
ND441_11390	COG0515	serine threonine protein kinase
ND441_11405	COG1403	HNH endonuclease
ND441_11420	COG4725	Belongs to the MT-A70-like family
ND441_11425	COG1802	Transcriptional regulator
ND441_11425	COG4626	Terminase
ND441_11460	COG5532	Uncharacterized conserved protein (DUF2303)
ND441_11465	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND441_11515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND441_11520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND441_11540	COG2223	nitrite transmembrane transporter activity
ND441_11545	COG0642	Histidine kinase
ND441_11545	COG2198	Histidine kinase
ND441_11555	COG0784	Response regulator, receiver
ND441_11555	COG2205	protein histidine kinase activity
ND441_11565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND441_11570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND441_11580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND441_11590	COG4574	serine-type endopeptidase inhibitor activity
ND441_11600	COG2246	polysaccharide biosynthetic process
ND441_11615	COG0814	amino acid
ND441_11640	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND441_11645	COG0596	Alpha beta hydrolase
ND441_11650	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND441_11655	COG1169	isochorismate synthase
ND441_11660	COG4575	ribosome binding
ND441_11675	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND441_11680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND441_11690	COG0839	Belongs to the complex I subunit 6 family
ND441_11695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND441_11700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND441_11705	COG1034	ATP synthesis coupled electron transport
ND441_11725	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND441_11730	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND441_11735	COG0583	DNA-binding transcription factor activity
ND441_11740	COG0436	Aminotransferase
ND441_11745	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND441_11750	COG0471	metal ion transport
ND441_11750	COG0490	domain, Protein
ND441_11760	COG3013	Belongs to the UPF0304 family
ND441_11765	COG3092	negative regulation of chromosome organization
ND441_11775	COG0280	phosphate acetyltransferase
ND441_11775	COG0857	belongs to the CobB CobQ family
ND441_11780	COG1609	Transcriptional regulator
ND441_11795	COG3037	sugar-specific permease SgaT UlaA
ND441_11800	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND441_11805	COG0622	Phosphoesterase
ND441_11820	COG0625	glutathione transferase activity
ND441_11825	COG1090	epimerase
ND441_11835	COG4160	amino acid transport
ND441_11840	COG4215	(ABC) transporter
ND441_11855	COG0163	prenyltransferase activity
ND441_11860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND441_11865	COG1286	toxin biosynthetic process
ND441_11870	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND441_11875	COG0285	dihydrofolate synthase activity
ND441_11885	COG0586	Pfam SNARE associated Golgi protein
ND441_11895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND441_11920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND441_11925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND441_11955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND441_11970	COG3101	peptidyl-lysine hydroxylation
ND441_11975	COG0730	response to heat
ND441_11980	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND441_11990	COG2890	protein-(glutamine-N5) methyltransferase activity
ND441_11995	COG2840	Smr protein MutS2
ND441_12000	COG2062	phosphohistidine phosphatase, SixA
ND441_12005	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND441_12005	COG1024	Enoyl-CoA hydratase
ND441_12010	COG0183	Belongs to the thiolase family
ND441_12015	COG3691	Protein conserved in bacteria
ND441_12030	COG4235	cytochrome complex assembly
ND441_12030	COG3088	subunit of a heme lyase
ND441_12035	COG4235	cytochrome complex assembly
ND441_12035	COG3088	subunit of a heme lyase
ND441_12040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND441_12045	COG1138	Cytochrome C-type biogenesis protein
ND441_12050	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND441_12055	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND441_12060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND441_12065	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND441_12080	COG0582	viral genome integration into host DNA
ND441_12085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ND441_12140	COG2824	Alkylphosphonate utilization operon protein PhnA
ND441_12145	COG2951	lytic endotransglycosylase activity
ND441_12150	COG1598	PFAM Uncharacterised protein family UPF0150
ND441_12160	COG3038	cytochrome b561
ND441_12165	COG0436	Aminotransferase
ND441_12175	COG3275	phosphorelay sensor kinase activity
ND441_12180	COG3279	Response regulator of the LytR AlgR family
ND441_12185	COG2223	nitrite transmembrane transporter activity
ND441_12190	COG0837	glucose binding
ND441_12210	COG1914	H( )-stimulated, divalent metal cation uptake system
ND441_12215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND441_12275	COG3530	Putative quorum-sensing-regulated virulence factor
ND441_12280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND441_12290	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND441_12300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND441_12315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND441_12325	COG4208	sulfate ABC transporter
ND441_12330	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND441_12335	COG4150	thiosulfate binding
ND441_12345	COG1737	Transcriptional regulator
ND441_12350	COG2731	YhcH YjgK YiaL family protein
ND441_12365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND441_12370	COG2837	iron assimilation
ND441_12380	COG3111	PFAM Bacterial OB fold (BOF) protein
ND441_12440	COG1671	Belongs to the UPF0178 family
ND441_12445	COG0281	malic enzyme
ND441_12445	COG0280	phosphate acetyltransferase
ND441_12450	COG0494	nUDIX hydrolase
ND441_12455	COG3005	denitrification pathway
ND441_12460	COG3043	anaerobic respiration
ND441_12465	COG0243	molybdopterin cofactor binding
ND441_12470	COG3062	negative regulation of establishment of protein localization
ND441_12475	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND441_12475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND441_12480	COG2197	response regulator
ND441_12490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND441_12500	COG1605	Chorismate mutase
ND441_12505	COG1393	Belongs to the ArsC family
ND441_12510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND441_12515	COG1876	peptidase activity
ND441_12525	COG0400	carboxylic ester hydrolase activity
ND441_12545	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND441_12550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND441_12555	COG2716	regulation of RNA biosynthetic process
ND441_12560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND441_12565	COG0628	permease
ND441_12570	COG4783	chaperone-mediated protein folding
ND441_12575	COG1393	Belongs to the ArsC family
ND441_12580	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND441_12585	COG2233	PERMEase
ND441_12590	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND441_12595	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND441_12600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND441_12605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND441_12615	COG0581	inorganic phosphate transmembrane transporter activity
ND441_12620	COG0573	inorganic phosphate transmembrane transporter activity
ND441_12625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND441_12640	COG2239	Acts as a magnesium transporter
ND441_12645	COG0443	Heat shock 70 kDa protein
ND441_12655	COG3121	Chaperone
ND441_12675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND441_12685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND441_12690	COG0477	Major facilitator Superfamily
ND441_12695	COG2205	protein histidine kinase activity
ND441_12700	COG0745	RESPONSE REGULATOR receiver
ND441_12705	COG3422	double-strand break repair
ND441_12710	COG0826	peptidase U32
ND441_12715	COG1597	lipid kinase activity
ND441_12730	COG0351	phosphomethylpyrimidine kinase
ND441_12745	COG0519	Catalyzes the synthesis of GMP from XMP
ND441_12745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND441_12750	COG0516	GMP reductase activity
ND441_12750	COG0517	IMP dehydrogenase activity
ND441_12755	COG1570	exodeoxyribonuclease VII activity
ND441_12760	COG1645	bacterial-type flagellum-dependent swarming motility
ND441_12770	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND441_12775	COG2976	Protein conserved in bacteria
ND441_12780	COG0124	histidyl-tRNA synthetase
ND441_12800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND441_12815	COG4953	penicillin-binding protein 1C
ND441_12820	COG2373	Large extracellular alpha-helical protein
ND441_12835	COG2975	iron-sulfur cluster assembly
ND441_12840	COG0633	Ferredoxin
ND441_12845	COG0443	Heat shock 70 kDa protein
ND441_12860	COG0822	iron-sulfur transferase activity
ND441_12870	COG1959	2 iron, 2 sulfur cluster binding
ND441_12875	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND441_12885	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND441_12890	COG3683	transport system, periplasmic component
ND441_12895	COG3711	transcriptional antiterminator
ND441_12900	COG2814	Major facilitator Superfamily
ND441_12910	COG1017	nitric oxide dioxygenase activity
ND441_12910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND441_12915	COG2188	Transcriptional regulator
ND441_12925	COG3457	Alanine racemase
ND441_12930	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND441_12945	COG0347	Belongs to the P(II) protein family
ND441_12950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND441_12950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND441_12955	COG2204	response regulator
ND441_12960	COG3170	Tfp pilus assembly protein FimV
ND441_12965	COG2205	protein histidine kinase activity
ND441_12980	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND441_12990	COG0560	Phosphoserine phosphatase
ND441_12995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND441_12995	COG1263	PTS System
ND441_13005	COG1737	Transcriptional regulator
ND441_13010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND441_13020	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND441_13030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND441_13045	COG0481	GTPase activity
ND441_13050	COG3086	response to oxidative stress
ND441_13060	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND441_13070	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND441_13080	COG0513	Belongs to the DEAD box helicase family
ND441_13095	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND441_13105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND441_13110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND441_13115	COG0497	DNA recombination
ND441_13120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND441_13130	COG2867	negative regulation of translational initiation
ND441_13135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND441_13145	COG0582	viral genome integration into host DNA
ND441_13175	COG3596	GTP binding
ND441_13180	COG2378	regulation of single-species biofilm formation
ND441_13190	COG2378	regulation of single-species biofilm formation
ND441_13215	COG2003	Belongs to the UPF0758 family
ND441_13270	COG3121	Chaperone
ND441_13275	COG3188	usher protein
ND441_13300	COG0583	DNA-binding transcription factor activity
ND441_13375	COG1069	ribulokinase activity
ND441_13385	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND441_13390	COG1129	ABC transporter
ND441_13410	COG1620	l-lactate permease
ND441_13415	COG1304	FMN binding
ND441_13420	COG0579	oxidoreductase
ND441_13425	COG1278	Cold shock
ND441_13455	COG1780	Probably involved in ribonucleotide reductase function
ND441_13460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND441_13470	COG4175	Glycine betaine
ND441_13475	COG4176	ABC-type proline glycine betaine transport system permease component
ND441_13480	COG2113	Glycine betaine
ND441_13490	COG2814	Major facilitator Superfamily
ND441_13495	COG1846	Transcriptional regulator
ND441_13505	COG1566	PFAM secretion protein HlyD family protein
ND441_13510	COG2814	Major facilitator Superfamily
ND441_13515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND441_13520	COG3118	belongs to the thioredoxin family
ND441_13525	COG3148	PFAM DTW domain containing protein
ND441_13530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND441_13530	COG0045	succinate-CoA ligase (ADP-forming) activity
ND441_13530	COG1042	CoA-binding domain protein
ND441_13535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND441_13540	COG5544	Lipoprotein
ND441_13565	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND441_13575	COG2011	ABC-type metal ion transport system permease component
ND441_13580	COG1464	Belongs to the NlpA lipoprotein family
ND441_13590	COG1720	tRNA m6t6A37 methyltransferase activity
ND441_13595	COG0442	prolyl-tRNA aminoacylation
ND441_13600	COG3015	lipoprotein NlpE involved in copper resistance
ND441_13610	COG4681	YaeQ
ND441_13620	COG4568	rho-dependent transcription termination
ND441_13635	COG0346	lactoylglutathione lyase activity
ND441_13650	COG0825	malonyl-CoA metabolic process
ND441_13655	COG0587	DNA-directed DNA polymerase activity
ND441_13660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND441_13680	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND441_13685	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND441_13695	COG0750	zinc metalloprotease
ND441_13700	COG0575	Belongs to the CDS family
ND441_13720	COG0528	UMP kinase activity
ND441_13725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND441_13740	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND441_13745	COG2171	N-acyltransferase activity
ND441_13760	COG0564	pseudouridine synthase activity
ND441_13765	COG3098	single-species biofilm formation
ND441_13780	COG1611	Belongs to the LOG family
ND441_13790	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND441_13795	COG2363	Small membrane protein
ND441_13800	COG0583	DNA-binding transcription factor activity
ND441_13810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND441_13815	COG2166	iron-sulfur cluster assembly
ND441_13820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND441_13825	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND441_13845	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND441_13850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND441_13850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND441_13855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND441_13860	COG1074	ATP-dependent DNA helicase activity
ND441_13865	COG1025	Belongs to the peptidase M16 family
ND441_13870	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND441_13875	COG4967	type IV pilus modification protein PilV
ND441_13900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND441_13905	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND441_13915	COG3066	DNA modification
ND441_13920	COG0861	Integral membrane protein TerC family
ND441_13925	COG0667	Aldo Keto reductase
ND441_13930	COG0477	Major facilitator Superfamily
ND441_13935	COG0318	PFAM AMP-dependent synthetase and ligase
ND441_13935	COG0204	Acyl-transferase
ND441_13940	COG1609	Transcriptional regulator
ND441_13950	COG0583	DNA-binding transcription factor activity
ND441_13955	COG0583	DNA-binding transcription factor activity
ND441_14010	COG2165	general secretion pathway protein
ND441_14020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND441_14050	COG1127	ABC transporter
ND441_14055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND441_14065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND441_14075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND441_14080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND441_14085	COG4974	Belongs to the 'phage' integrase family
ND441_14090	COG0716	FMN binding
ND441_14100	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND441_14110	COG1272	protein, Hemolysin III
ND441_14130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND441_14135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND441_14140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND441_14145	COG0006	proline dipeptidase activity
ND441_14155	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND441_14165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND441_14170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND441_14175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND441_14190	COG1279	arginine transmembrane transporter activity
ND441_14200	COG0191	fructose-bisphosphate aldolase activity
ND441_14205	COG0126	phosphoglycerate kinase activity
ND441_14210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND441_14215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND441_14225	COG1166	arginine decarboxylase activity
ND441_14230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND441_14245	COG0640	Transcriptional regulator
ND441_14250	COG3091	SprT-like family
ND441_14255	COG2356	endonuclease I
ND441_14260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND441_14265	COG0189	ligase activity
ND441_14270	COG1678	Uncharacterized ACR, COG1678
ND441_14275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND441_14280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND441_14290	COG2805	Type II/IV secretion system protein
ND441_14295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND441_14300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND441_14305	COG0762	integral membrane protein
ND441_14310	COG1872	DUF167
ND441_14315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND441_14320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND441_14335	COG3171	Protein conserved in bacteria
ND441_14345	COG1194	a g-specific adenine glycosylase
ND441_14350	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND441_14355	COG0741	lytic transglycosylase activity
ND441_14400	COG1105	Belongs to the carbohydrate kinase PfkB family
ND441_14405	COG1882	Formate acetyltransferase
ND441_14410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND441_14415	COG0814	amino acid
ND441_14430	COG1028	Short-chain dehydrogenase reductase Sdr
ND441_14435	COG3433	isochorismatase activity
ND441_14435	COG1535	isochorismatase
ND441_14440	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND441_14445	COG1169	isochorismate synthase
ND441_14450	COG4592	Periplasmic binding protein
ND441_14460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND441_14465	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND441_14470	COG1120	ATPase activity
ND441_14480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND441_14485	COG3251	PFAM MbtH domain protein
ND441_14495	COG4774	siderophore transport
ND441_14500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND441_14525	COG4964	Belongs to the GSP D family
ND441_14585	COG0848	biopolymer transport protein
ND441_14590	COG0811	peptide transport
ND441_14595	COG0626	cystathionine gamma-synthase activity
ND441_14600	COG0586	Pfam SNARE associated Golgi protein
ND441_14605	COG2207	Transcriptional regulator
ND441_14610	COG1979	alcohol dehydrogenase
ND441_14615	COG0656	L-ascorbic acid biosynthetic process
ND441_14625	COG2132	Multicopper oxidase
ND441_14640	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND441_14645	COG0583	DNA-binding transcription factor activity
ND441_14650	COG0187	DNA topoisomerase II activity
ND441_14655	COG3150	esterase
ND441_14660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND441_14665	COG3151	Protein conserved in bacteria
ND441_14670	COG0494	nUDIX hydrolase
ND441_14675	COG1538	Outer membrane efflux protein
ND441_14680	COG5463	Belongs to the UPF0441 family
ND441_14685	COG0754	glutathionylspermidine amidase activity
ND441_14690	COG3384	dioxygenase
ND441_14695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND441_14710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND441_14710	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND441_14720	COG3025	triphosphatase activity
ND441_14725	COG4991	sh3 domain protein
ND441_14730	COG0617	tRNA 3'-terminal CCA addition
ND441_14735	COG1968	undecaprenyl-diphosphatase activity
ND441_14740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND441_14745	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND441_14750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND441_14755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND441_14760	COG0358	DNA primase activity
ND441_14790	COG1028	Short-chain dehydrogenase reductase Sdr
ND441_14820	COG0463	Glycosyl transferase, family 2
ND441_14855	COG3210	domain, Protein
ND441_14860	COG3210	domain, Protein
ND441_14870	COG2831	hemolysin activation secretion protein
ND441_14875	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND441_14875	COG1902	pentaerythritol trinitrate reductase activity
ND441_14890	COG1451	nucleotide metabolic process
ND441_14895	COG0673	inositol 2-dehydrogenase activity
ND441_14900	COG0861	Integral membrane protein TerC family
ND441_14905	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND441_14915	COG2721	sulfolactate sulfo-lyase activity
ND441_14930	COG2271	Major facilitator Superfamily
ND441_14945	COG0586	Pfam SNARE associated Golgi protein
ND441_14960	COG4575	ribosome binding
ND441_14965	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND441_14975	COG2259	Doxx family
ND441_14980	COG0583	DNA-binding transcription factor activity
ND441_14985	COG1741	Belongs to the pirin family
ND441_15000	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ND441_15015	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND441_15020	COG2823	Periplasmic or secreted lipoprotein
ND441_15025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND441_15030	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND441_15035	COG5002	protein histidine kinase activity
ND441_15035	COG2198	Histidine kinase
ND441_15035	COG0784	Response regulator, receiver
ND441_15040	COG1242	4 iron, 4 sulfur cluster binding
ND441_15045	COG0067	glutamate synthase
ND441_15045	COG0070	glutamate synthase
ND441_15045	COG0069	glutamate synthase activity
ND441_15050	COG0493	'glutamate synthase
ND441_15060	COG2969	positive regulation of protein catabolic process
ND441_15065	COG0625	glutathione transferase activity
ND441_15070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND441_15075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND441_15080	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND441_15085	COG3105	Protein conserved in bacteria
ND441_15090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND441_15100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND441_15105	COG5007	Belongs to the BolA IbaG family
ND441_15110	COG3113	response to antibiotic
ND441_15115	COG2854	intermembrane phospholipid transfer
ND441_15120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND441_15125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND441_15130	COG1127	ABC transporter
ND441_15135	COG0530	calcium, potassium:sodium antiporter activity
ND441_15140	COG0517	IMP dehydrogenase activity
ND441_15140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND441_15145	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND441_15150	COG3117	lipopolysaccharide transmembrane transporter activity
ND441_15155	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND441_15160	COG1137	ATPase activity
ND441_15165	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND441_15185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND441_15190	COG0540	Belongs to the ATCase OTCase family
ND441_15195	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND441_15205	COG0366	Alpha amylase catalytic
ND441_15210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND441_15210	COG1263	PTS System
ND441_15220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND441_15230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND441_15235	COG3783	Cytochrome b(562)
ND441_15240	COG0312	modulator of DNA gyrase
ND441_15245	COG3028	Belongs to the UPF0307 family
ND441_15250	COG2732	(Barnase) inhibitor
ND441_15255	COG4290	ribonuclease
ND441_15265	COG1289	transmembrane transporter activity
ND441_15270	COG1566	PFAM secretion protein HlyD family protein
ND441_15280	COG0583	DNA-binding transcription factor activity
ND441_15285	COG0312	modulator of DNA gyrase
ND441_15290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND441_15295	COG3164	Protein of unknown function
ND441_15305	COG0424	maF-like protein
ND441_15310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND441_15315	COG1792	Involved in formation and maintenance of cell shape
ND441_15320	COG1077	Cell shape determining protein MreB Mrl
ND441_15325	COG2200	EAL domain
ND441_15325	COG2199	diguanylate cyclase activity
ND441_15330	COG0604	alcohol dehydrogenase
ND441_15335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND441_15340	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND441_15350	COG0511	ligase activity, forming carbon-carbon bonds
ND441_15355	COG0439	Biotin carboxylase
ND441_15360	COG3924	membrane
ND441_15365	COG4145	pantothenate transmembrane transporter activity
ND441_15370	COG2264	protein methyltransferase activity
ND441_15375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND441_15380	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND441_15390	COG1560	Kdo2-lipid A biosynthetic process
ND441_15400	COG1346	cytolysis
ND441_15405	COG1380	Effector of murein hydrolase LrgA
ND441_15410	COG0583	DNA-binding transcription factor activity
ND441_15415	COG0025	NhaP-type Na H and K H
ND441_15420	COG2252	PERMEase
ND441_15435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND441_15440	COG2315	Protein conserved in bacteria
ND441_15445	COG1448	Aminotransferase
ND441_15470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND441_15475	COG0735	belongs to the Fur family
ND441_15480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND441_15485	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND441_15490	COG2937	Belongs to the GPAT DAPAT family
ND441_15510	COG4580	involved in the transport of maltose and maltodextrins
ND441_15525	COG2182	Extracellular solute-binding protein
ND441_15530	COG1175	transmembrane transport
ND441_15535	COG3833	ABC-type maltose transport systems, permease component
ND441_15540	COG3223	Belongs to the PsiE family
ND441_15550	COG0527	aspartate kinase activity
ND441_15565	COG3328	transposase activity
ND441_15575	COG3328	transposase activity
ND441_15600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ND441_15680	COG0583	DNA-binding transcription factor activity
ND441_15720	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND441_15760	COG0138	bifunctional purine biosynthesis protein purh
ND441_15765	COG0151	Belongs to the GarS family
ND441_15785	COG1515	deoxyribonuclease V activity
ND441_15790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND441_15795	COG2816	NAD+ diphosphatase activity
ND441_15800	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND441_15815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND441_15820	COG2104	thiamine diphosphate biosynthetic process
ND441_15825	COG2022	thiamine diphosphate biosynthetic process
ND441_15835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND441_15840	COG0085	RNA polymerase activity
ND441_15845	COG0222	ribosome binding
ND441_15850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND441_15860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND441_15865	COG0250	Participates in transcription elongation, termination and antitermination
ND441_15910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND441_15935	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND441_15940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND441_15945	COG1739	Uncharacterized protein family UPF0029
ND441_15955	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND441_15955	COG1024	Enoyl-CoA hydratase
ND441_15965	COG0543	2 iron, 2 sulfur cluster binding
ND441_15980	COG0250	Participates in transcription elongation, termination and antitermination
ND441_15995	COG0805	protein transport
ND441_16000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND441_16005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND441_16010	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND441_16015	COG3165	ubiquinone biosynthetic process from chorismate
ND441_16020	COG2226	methyltransferase
ND441_16025	COG1322	Protein conserved in bacteria
ND441_16030	COG0586	Pfam SNARE associated Golgi protein
ND441_16035	COG1966	Carbon starvation protein
ND441_16050	COG0412	Dienelactone hydrolase
ND441_16055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND441_16060	COG0583	DNA-binding transcription factor activity
ND441_16065	COG0697	spore germination
ND441_16075	COG0584	glycerophosphoryl diester phosphodiesterase
ND441_16085	COG0395	ABC-type sugar transport system, permease component
ND441_16090	COG1175	transmembrane transport
ND441_16095	COG1653	transport
ND441_16130	COG0410	ABC transporter
ND441_16140	COG4177	L-phenylalanine transmembrane transporter activity
ND441_16160	COG1929	Belongs to the glycerate kinase type-1 family
ND441_16165	COG2610	gluconate transmembrane transporter activity
ND441_16170	COG3835	regulator
ND441_16180	COG2177	Part of the ABC transporter FtsEX involved in
ND441_16185	COG2884	Cell division ATP-binding protein ftsE
ND441_16190	COG0552	protein localization to endoplasmic reticulum
ND441_16190	COG0552	protein localization to endoplasmic reticulum
ND441_16195	COG0742	ribosomal rna small subunit methyltransferase
ND441_16200	COG3776	membrane
ND441_16215	COG3714	YhhN family
ND441_16230	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND441_16240	COG0247	lactate metabolic process
ND441_16250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND441_16260	COG2271	Major facilitator Superfamily
ND441_16265	COG0584	glycerophosphoryl diester phosphodiesterase
ND441_16270	COG0561	phosphatase activity
ND441_16275	COG2267	carboxylic ester hydrolase activity
ND441_16280	COG1280	lysine exporter protein (LysE YggA)
ND441_16285	COG0514	ATP-dependent DNA helicase (RecQ)
ND441_16290	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND441_16295	COG2050	protein possibly involved in aromatic compounds catabolism
ND441_16315	COG5564	TIM-barrel signal transduction protein
ND441_16320	COG5441	Belongs to the UPF0261 family
ND441_16330	COG0210	DNA helicase
ND441_16335	COG1011	Hydrolase
ND441_16340	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND441_16345	COG3159	Protein conserved in bacteria
ND441_16350	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND441_16355	COG5567	small periplasmic lipoprotein
ND441_16365	COG3072	Adenylate cyclase
ND441_16370	COG0181	hydroxymethylbilane synthase activity
ND441_16375	COG1587	Uroporphyrinogen-III synthase
ND441_16380	COG2959	enzyme of heme biosynthesis
ND441_16385	COG3071	HemY protein
ND441_16435	COG2244	polysaccharide biosynthetic process
ND441_16440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND441_16445	COG0456	acetyltransferase
ND441_16450	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND441_16455	COG1088	dTDP-glucose 4,6-dehydratase activity
ND441_16460	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND441_16465	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND441_16470	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND441_16475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND441_16480	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND441_16485	COG3118	belongs to the thioredoxin family
ND441_16495	COG0248	Ppx GppA phosphatase
ND441_16505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND441_16520	COG3397	chitin binding
ND441_16530	COG0129	dihydroxy-acid dehydratase activity
ND441_16540	COG3978	acetolactate synthase activity
ND441_16560	COG3085	chromosome segregation
ND441_16565	COG0583	DNA-binding transcription factor activity
ND441_16640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND441_16650	COG0678	peroxiredoxin activity
ND441_16650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND441_16655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND441_16690	COG1629	transport
ND441_16695	COG0165	Argininosuccinate lyase
ND441_16700	COG0137	argininosuccinate synthase activity
ND441_16705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND441_16750	COG0460	homoserine dehydrogenase
ND441_16750	COG0527	aspartate kinase activity
ND441_16755	COG0626	cystathionine gamma-synthase activity
ND441_16760	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND441_16770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND441_16775	COG1609	Transcriptional regulator
ND441_16780	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND441_16785	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND441_16790	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND441_16795	COG1575	Belongs to the MenA family. Type 1 subfamily
ND441_16800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND441_16805	COG3074	FtsZ-dependent cytokinesis
ND441_16810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND441_16815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND441_16820	COG1494	fructose-1,6-bisphosphatase
ND441_16825	COG2814	Major facilitator Superfamily
ND441_16835	COG3152	Membrane
ND441_16850	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND441_16860	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND441_16865	COG3678	ATP-independent chaperone mediated protein folding
ND441_16870	COG0745	RESPONSE REGULATOR receiver
ND441_16875	COG2205	protein histidine kinase activity
ND441_16880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND441_16885	COG1045	serine acetyltransferase
ND441_16890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND441_16895	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND441_16900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND441_16905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND441_16910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND441_16915	COG4942	peptidase
ND441_16920	COG2861	carbohydrate metabolic process
ND441_16935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND441_16940	COG0859	PFAM glycosyl transferase family 9
ND441_16945	COG0859	PFAM glycosyl transferase family 9
ND441_16950	COG1519	Transferase
ND441_16970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND441_16975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND441_16980	COG2003	Belongs to the UPF0758 family
ND441_16985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND441_16990	COG0756	dUTP diphosphatase activity
ND441_16995	COG1309	transcriptional regulator
ND441_17000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND441_17005	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND441_17010	COG1561	YicC-like family, N-terminal region
ND441_17025	COG5001	Diguanylate cyclase
ND441_17030	COG1024	Enoyl-CoA hydratase
ND441_17035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND441_17045	COG2860	membrane
ND441_17050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND441_17060	COG1758	RNA polymerase activity
ND441_17065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND441_17070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND441_17075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND441_17080	COG0786	glutamate:sodium symporter activity
ND441_17085	COG2233	PERMEase
ND441_17090	COG2982	Protein involved in outer membrane biogenesis
ND441_17095	COG0456	acetyltransferase
ND441_17110	COG1011	Hydrolase
ND441_17125	COG3852	Histidine kinase
ND441_17135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND441_17145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND441_17150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND441_17150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND441_17155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND441_17160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND441_17165	COG3084	Protein conserved in bacteria
ND441_17175	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND441_17200	COG2186	Transcriptional regulator
ND441_17205	COG1609	Transcriptional regulator
ND441_17210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND441_17220	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND441_17225	COG1129	ABC transporter
ND441_17230	COG1869	D-ribose catabolic process
ND441_17235	COG3158	transport of potassium into the cell
ND441_17240	COG0714	Associated with various cellular activities
ND441_17245	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND441_17255	COG2502	aspartate--ammonia ligase
ND441_17260	COG1522	sequence-specific DNA binding
ND441_17265	COG0716	FMN binding
ND441_17270	COG0445	tRNA wobble uridine modification
ND441_17275	COG0357	Ribosomal RNA small subunit methyltransferase G
ND441_17280	COG3312	ion transport
ND441_17285	COG0356	it plays a direct role in the translocation of protons across the membrane
ND441_17295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND441_17305	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND441_17310	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND441_17320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND441_17335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND441_17340	COG0573	inorganic phosphate transmembrane transporter activity
ND441_17345	COG0581	inorganic phosphate transmembrane transporter activity
ND441_17355	COG0704	Plays a role in the regulation of phosphate uptake
ND441_17360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND441_17365	COG0765	amino acid transport
ND441_17370	COG0765	amino acid transport
ND441_17375	COG2252	PERMEase
ND441_17380	COG0840	transmembrane signaling receptor activity
ND441_17390	COG3121	Chaperone
ND441_17405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND441_17410	COG0706	membrane insertase activity
ND441_17420	COG0594	ribonuclease P activity
ND441_17425	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ND441_17430	COG5301	cellulose 1,4-beta-cellobiosidase activity
ND441_17480	COG4386	tail sheath protein
ND441_17505	COG4397	Mu-like prophage major head subunit gpT
ND441_17530	COG4383	Mu-like prophage protein gp29
ND441_17585	COG4382	Mu-like prophage protein Gp16
ND441_17650	COG3423	Transcriptional regulator
ND441_17815	COG2944	sequence-specific DNA binding
ND441_17885	COG1192	Involved in chromosome partitioning
ND441_17960	COG1454	alcohol dehydrogenase
ND441_18065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND441_18080	COG0741	lytic transglycosylase activity
ND441_18095	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs