locus-tag	class	description
BD65_1	COG0308	aminopeptidase N
BD65_10	COG3130	regulation of translation
BD65_100	COG0471	metal ion transport
BD65_1000	COG0581	inorganic phosphate transmembrane transporter activity
BD65_1001	COG0573	inorganic phosphate transmembrane transporter activity
BD65_1002	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BD65_1003	COG0248	Ppx GppA phosphatase
BD65_1005	COG2239	Acts as a magnesium transporter
BD65_1006	COG0443	Heat shock 70 kDa protein
BD65_1008	COG3121	Chaperone
BD65_1011	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BD65_1013	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BD65_1014	COG0477	Major facilitator Superfamily
BD65_1015	COG2205	protein histidine kinase activity
BD65_1016	COG0745	RESPONSE REGULATOR receiver
BD65_1017	COG3422	double-strand break repair
BD65_1019	COG1597	lipid kinase activity
BD65_1022	COG0351	phosphomethylpyrimidine kinase
BD65_1024	COG0519	Catalyzes the synthesis of GMP from XMP
BD65_1024	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BD65_1025	COG0516	GMP reductase activity
BD65_1025	COG0517	IMP dehydrogenase activity
BD65_1026	COG1570	exodeoxyribonuclease VII activity
BD65_1027	COG1645	bacterial-type flagellum-dependent swarming motility
BD65_1029	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BD65_1030	COG2976	Protein conserved in bacteria
BD65_1031	COG0124	histidyl-tRNA synthetase
BD65_1038	COG4953	penicillin-binding protein 1C
BD65_1039	COG2373	Large extracellular alpha-helical protein
BD65_1042	COG2975	iron-sulfur cluster assembly
BD65_1043	COG0633	Ferredoxin
BD65_1044	COG0443	Heat shock 70 kDa protein
BD65_1045	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BD65_1047	COG0822	iron-sulfur transferase activity
BD65_1049	COG1959	2 iron, 2 sulfur cluster binding
BD65_1050	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BD65_1052	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BD65_1053	COG3683	transport system, periplasmic component
BD65_1054	COG2814	Major facilitator Superfamily
BD65_1055	COG3711	transcriptional antiterminator
BD65_1057	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BD65_1057	COG1017	nitric oxide dioxygenase activity
BD65_1058	COG2188	Transcriptional regulator
BD65_1060	COG3457	Alanine racemase
BD65_1061	COG1735	metal-dependent hydrolase with the TIM-barrel fold
BD65_1064	COG0347	Belongs to the P(II) protein family
BD65_1065	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BD65_1065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BD65_1066	COG2204	response regulator
BD65_1067	COG3170	Tfp pilus assembly protein FimV
BD65_1068	COG2205	protein histidine kinase activity
BD65_107	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
BD65_1071	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BD65_1072	COG0590	tRNA wobble adenosine to inosine editing
BD65_1076	COG1737	Transcriptional regulator
BD65_1077	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BD65_1078	COG0736	holo-[acyl-carrier-protein] synthase activity
BD65_1079	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BD65_108	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BD65_1081	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BD65_1083	COG0681	Belongs to the peptidase S26 family
BD65_1084	COG0481	GTPase activity
BD65_1085	COG3086	response to oxidative stress
BD65_1087	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
BD65_1089	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BD65_1091	COG0513	Belongs to the DEAD box helicase family
BD65_1094	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
BD65_1096	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BD65_1097	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BD65_1098	COG0497	DNA recombination
BD65_1099	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BD65_11	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BD65_1101	COG2867	negative regulation of translational initiation
BD65_1102	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BD65_1103	COG0582	viral genome integration into host DNA
BD65_1105	COG1204	response to ionizing radiation
BD65_111	COG4977	sequence-specific DNA binding
BD65_1115	COG0582	viral genome integration into host DNA
BD65_1118	COG2963	transposase activity
BD65_1120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BD65_1122	COG1172	Belongs to the binding-protein-dependent transport system permease family
BD65_1123	COG1129	ABC transporter
BD65_1127	COG1620	l-lactate permease
BD65_1128	COG1304	FMN binding
BD65_1129	COG0579	oxidoreductase
BD65_113	COG1702	phosphate starvation-inducible protein PhoH
BD65_1133	COG1278	Cold shock
BD65_1139	COG1780	Probably involved in ribonucleotide reductase function
BD65_114	COG0387	Pfam Sodium calcium exchanger
BD65_1140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BD65_1141	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BD65_1142	COG4175	Glycine betaine
BD65_1143	COG4176	ABC-type proline glycine betaine transport system permease component
BD65_1144	COG2113	Glycine betaine
BD65_1147	COG1846	Transcriptional regulator
BD65_1149	COG1566	PFAM secretion protein HlyD family protein
BD65_115	COG2375	cellular response to nickel ion
BD65_1150	COG2814	Major facilitator Superfamily
BD65_1151	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BD65_1152	COG3118	belongs to the thioredoxin family
BD65_1154	COG0045	succinate-CoA ligase (ADP-forming) activity
BD65_1154	COG1042	CoA-binding domain protein
BD65_1154	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BD65_1155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BD65_1156	COG5544	Lipoprotein
BD65_116	COG3850	Histidine kinase
BD65_1161	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BD65_1163	COG2011	ABC-type metal ion transport system permease component
BD65_1164	COG1464	Belongs to the NlpA lipoprotein family
BD65_1166	COG1720	tRNA m6t6A37 methyltransferase activity
BD65_1167	COG0442	prolyl-tRNA aminoacylation
BD65_1168	COG3015	lipoprotein NlpE involved in copper resistance
BD65_1170	COG4681	YaeQ
BD65_1172	COG4568	rho-dependent transcription termination
BD65_1174	COG0037	tRNA processing
BD65_1175	COG0346	lactoylglutathione lyase activity
BD65_1179	COG0825	malonyl-CoA metabolic process
BD65_118	COG1294	oxidase, subunit
BD65_1180	COG0587	DNA-directed DNA polymerase activity
BD65_1181	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BD65_1182	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BD65_1185	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BD65_1186	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
BD65_1188	COG0750	zinc metalloprotease
BD65_1189	COG0575	Belongs to the CDS family
BD65_119	COG1271	oxidase subunit
BD65_1190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BD65_1193	COG0528	UMP kinase activity
BD65_1194	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BD65_1196	COG0024	Methionine aminopeptidase
BD65_1197	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BD65_1198	COG2171	N-acyltransferase activity
BD65_12	COG1067	ATP-dependent peptidase activity
BD65_120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BD65_1201	COG0564	pseudouridine synthase activity
BD65_1202	COG3098	single-species biofilm formation
BD65_1205	COG1611	Belongs to the LOG family
BD65_1207	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BD65_1208	COG2363	Small membrane protein
BD65_1209	COG0583	DNA-binding transcription factor activity
BD65_121	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BD65_1210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BD65_1211	COG2166	iron-sulfur cluster assembly
BD65_1212	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BD65_1213	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BD65_1217	COG0860	N-Acetylmuramoyl-L-alanine amidase
BD65_1218	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BD65_1218	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BD65_1219	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BD65_122	COG3138	arginine N-succinyltransferase
BD65_1220	COG1074	ATP-dependent DNA helicase activity
BD65_1221	COG1025	Belongs to the peptidase M16 family
BD65_1222	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BD65_1227	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BD65_1228	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
BD65_1230	COG3066	DNA modification
BD65_1231	COG0861	Integral membrane protein TerC family
BD65_1232	COG0667	Aldo Keto reductase
BD65_1233	COG0477	Major facilitator Superfamily
BD65_1234	COG0318	PFAM AMP-dependent synthetase and ligase
BD65_1234	COG0204	Acyl-transferase
BD65_1235	COG1609	Transcriptional regulator
BD65_1236	COG0019	diaminopimelate decarboxylase activity
BD65_1237	COG0583	DNA-binding transcription factor activity
BD65_1238	COG0583	DNA-binding transcription factor activity
BD65_124	COG3724	N-succinylarginine dihydrolase activity
BD65_1249	COG2165	general secretion pathway protein
BD65_1251	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BD65_1259	COG1127	ABC transporter
BD65_1260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BD65_1262	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BD65_1263	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BD65_1264	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BD65_1265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BD65_1266	COG4974	Belongs to the 'phage' integrase family
BD65_1267	COG0716	FMN binding
BD65_1269	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BD65_1271	COG1272	protein, Hemolysin III
BD65_1277	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BD65_1278	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BD65_1279	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BD65_128	COG1228	amidohydrolase
BD65_1280	COG0006	proline dipeptidase activity
BD65_1282	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BD65_1283	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BD65_1284	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BD65_1285	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BD65_1288	COG1279	arginine transmembrane transporter activity
BD65_1290	COG0191	fructose-bisphosphate aldolase activity
BD65_1291	COG0126	phosphoglycerate kinase activity
BD65_1292	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BD65_1293	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BD65_1296	COG1166	arginine decarboxylase activity
BD65_1297	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BD65_13	COG3120	sequence-specific DNA binding
BD65_130	COG0402	S-adenosylhomocysteine deaminase activity
BD65_1300	COG0640	Transcriptional regulator
BD65_1301	COG3091	SprT-like family
BD65_1302	COG2356	endonuclease I
BD65_1303	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BD65_1304	COG0189	ligase activity
BD65_1305	COG1678	Uncharacterized ACR, COG1678
BD65_1307	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BD65_1308	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BD65_1310	COG2805	Type II/IV secretion system protein
BD65_1311	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BD65_1312	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BD65_1313	COG0762	integral membrane protein
BD65_1314	COG1872	DUF167
BD65_1315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BD65_1316	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BD65_1318	COG2066	Belongs to the glutaminase family
BD65_1319	COG3171	Protein conserved in bacteria
BD65_1321	COG1194	a g-specific adenine glycosylase
BD65_1322	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BD65_1323	COG0741	lytic transglycosylase activity
BD65_1325	COG2336	PFAM SpoVT AbrB
BD65_1326	COG2337	Toxic component of a toxin-antitoxin (TA) module
BD65_1330	COG1105	Belongs to the carbohydrate kinase PfkB family
BD65_1332	COG1882	Formate acetyltransferase
BD65_1333	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BD65_1334	COG0814	amino acid
BD65_1338	COG1028	Short-chain dehydrogenase reductase Sdr
BD65_1339	COG3433	isochorismatase activity
BD65_1339	COG1535	isochorismatase
BD65_1340	COG1021	2,3-dihydroxybenzoate-AMP ligase
BD65_1341	COG1169	isochorismate synthase
BD65_1342	COG4592	Periplasmic binding protein
BD65_1344	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BD65_1345	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BD65_1346	COG1120	ATPase activity
BD65_1348	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BD65_1349	COG3251	PFAM MbtH domain protein
BD65_1351	COG4774	siderophore transport
BD65_1352	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BD65_1357	COG4964	Belongs to the GSP D family
BD65_1367	COG0848	biopolymer transport protein
BD65_1368	COG0811	peptide transport
BD65_1369	COG0626	cystathionine gamma-synthase activity
BD65_1370	COG0586	Pfam SNARE associated Golgi protein
BD65_1371	COG2207	Transcriptional regulator
BD65_1372	COG1979	alcohol dehydrogenase
BD65_1374	COG0656	L-ascorbic acid biosynthetic process
BD65_1376	COG2132	Multicopper oxidase
BD65_1377	COG0204	Acyl-transferase
BD65_1379	COG2249	NAD(P)H dehydrogenase (quinone) activity
BD65_1381	COG0187	DNA topoisomerase II activity
BD65_1382	COG3150	esterase
BD65_1383	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BD65_1384	COG3151	Protein conserved in bacteria
BD65_1385	COG0494	nUDIX hydrolase
BD65_1386	COG1538	Outer membrane efflux protein
BD65_1388	COG0754	glutathionylspermidine amidase activity
BD65_1389	COG3384	dioxygenase
BD65_139	COG0012	GTP binding
BD65_1390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BD65_1392	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BD65_1392	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BD65_1394	COG3025	triphosphatase activity
BD65_1395	COG4991	sh3 domain protein
BD65_1396	COG0617	tRNA 3'-terminal CCA addition
BD65_1397	COG1968	undecaprenyl-diphosphatase activity
BD65_1398	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BD65_1399	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BD65_14	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BD65_14	COG2885	chlorophyll binding
BD65_1400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BD65_1402	COG0358	DNA primase activity
BD65_1403	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BD65_141	COG0193	aminoacyl-tRNA hydrolase activity
BD65_1410	COG2003	Belongs to the UPF0758 family
BD65_1414	COG2378	regulation of single-species biofilm formation
BD65_1415	COG3596	GTP binding
BD65_1422	COG1479	Protein of unknown function DUF262
BD65_1424	COG1204	response to ionizing radiation
BD65_1429	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BD65_143	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BD65_1438	COG2963	transposase activity
BD65_1439	COG1388	LysM domain
BD65_1441	COG2963	transposase activity
BD65_1444	COG1028	Short-chain dehydrogenase reductase Sdr
BD65_1447	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BD65_145	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BD65_1454	COG3210	domain, Protein
BD65_1455	COG3210	domain, Protein
BD65_1456	COG2831	hemolysin activation secretion protein
BD65_1457	COG0446	pyridine nucleotide-disulphide oxidoreductase
BD65_1457	COG1902	pentaerythritol trinitrate reductase activity
BD65_146	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BD65_1460	COG1451	nucleotide metabolic process
BD65_1461	COG0673	inositol 2-dehydrogenase activity
BD65_1462	COG0861	Integral membrane protein TerC family
BD65_1463	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BD65_1465	COG2721	sulfolactate sulfo-lyase activity
BD65_1466	COG0246	Mannitol dehydrogenase
BD65_1468	COG2271	Major facilitator Superfamily
BD65_147	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BD65_1471	COG0586	Pfam SNARE associated Golgi protein
BD65_1474	COG4575	ribosome binding
BD65_1475	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
BD65_1477	COG2259	Doxx family
BD65_1478	COG0583	DNA-binding transcription factor activity
BD65_1479	COG1741	Belongs to the pirin family
BD65_148	COG2890	protein-(glutamine-N5) methyltransferase activity
BD65_1480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BD65_1483	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BD65_1484	COG2823	Periplasmic or secreted lipoprotein
BD65_1485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BD65_1486	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BD65_1487	COG5002	protein histidine kinase activity
BD65_1487	COG2198	Histidine kinase
BD65_1487	COG0784	Response regulator, receiver
BD65_1488	COG1242	4 iron, 4 sulfur cluster binding
BD65_1489	COG0070	glutamate synthase
BD65_1489	COG0069	glutamate synthase activity
BD65_1489	COG0067	glutamate synthase
BD65_149	COG3094	Invasion gene expression up-regulator, SirB
BD65_1490	COG0493	'glutamate synthase
BD65_1494	COG2969	positive regulation of protein catabolic process
BD65_1495	COG0625	glutathione transferase activity
BD65_1496	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BD65_1497	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BD65_1498	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BD65_1499	COG3105	Protein conserved in bacteria
BD65_15	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
BD65_150	COG2912	Transglutaminase-like superfamily
BD65_1500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BD65_1502	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BD65_1503	COG5007	Belongs to the BolA IbaG family
BD65_1504	COG3113	response to antibiotic
BD65_1505	COG2854	intermembrane phospholipid transfer
BD65_1506	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BD65_1507	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BD65_1508	COG1127	ABC transporter
BD65_1509	COG0530	calcium, potassium:sodium antiporter activity
BD65_151	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BD65_1510	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BD65_1510	COG0517	IMP dehydrogenase activity
BD65_1511	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BD65_1512	COG3117	lipopolysaccharide transmembrane transporter activity
BD65_1513	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BD65_1514	COG1137	ATPase activity
BD65_1515	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BD65_1517	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BD65_1519	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BD65_152	COG0659	secondary active sulfate transmembrane transporter activity
BD65_1521	COG0540	Belongs to the ATCase OTCase family
BD65_1522	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BD65_1524	COG0366	Alpha amylase catalytic
BD65_1525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BD65_1525	COG1263	PTS System
BD65_1527	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BD65_1530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BD65_1531	COG3783	Cytochrome b(562)
BD65_1532	COG0312	modulator of DNA gyrase
BD65_1533	COG3028	Belongs to the UPF0307 family
BD65_1534	COG2732	(Barnase) inhibitor
BD65_1535	COG4290	ribonuclease
BD65_1537	COG1289	transmembrane transporter activity
BD65_1538	COG1566	PFAM secretion protein HlyD family protein
BD65_154	COG3706	GGDEF domain
BD65_1540	COG0583	DNA-binding transcription factor activity
BD65_1541	COG0312	modulator of DNA gyrase
BD65_1542	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BD65_1543	COG3164	Protein of unknown function
BD65_1544	COG1530	ribonuclease E activity
BD65_1546	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BD65_1547	COG1792	Involved in formation and maintenance of cell shape
BD65_1548	COG1077	Cell shape determining protein MreB Mrl
BD65_1549	COG2199	diguanylate cyclase activity
BD65_1549	COG2200	EAL domain
BD65_1550	COG0604	alcohol dehydrogenase
BD65_1551	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BD65_1552	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BD65_1554	COG0511	ligase activity, forming carbon-carbon bonds
BD65_1555	COG0439	Biotin carboxylase
BD65_1556	COG3924	membrane
BD65_1557	COG4145	pantothenate transmembrane transporter activity
BD65_1558	COG2264	protein methyltransferase activity
BD65_1559	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BD65_1560	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BD65_1562	COG1560	Kdo2-lipid A biosynthetic process
BD65_1564	COG1346	cytolysis
BD65_1565	COG1380	Effector of murein hydrolase LrgA
BD65_1566	COG0583	DNA-binding transcription factor activity
BD65_1567	COG0025	NhaP-type Na H and K H
BD65_1568	COG2252	PERMEase
BD65_1572	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BD65_1573	COG2315	Protein conserved in bacteria
BD65_1574	COG1448	Aminotransferase
BD65_1576	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BD65_1577	COG0305	Participates in initiation and elongation during chromosome replication
BD65_1578	COG0604	alcohol dehydrogenase
BD65_1580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BD65_1581	COG0735	belongs to the Fur family
BD65_1582	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BD65_1583	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BD65_1584	COG2937	Belongs to the GPAT DAPAT family
BD65_1588	COG4580	involved in the transport of maltose and maltodextrins
BD65_159	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BD65_1591	COG2182	Extracellular solute-binding protein
BD65_1592	COG1175	transmembrane transport
BD65_1593	COG3833	ABC-type maltose transport systems, permease component
BD65_1594	COG3223	Belongs to the PsiE family
BD65_1597	COG0527	aspartate kinase activity
BD65_16	COG3070	regulator of competence-specific genes
BD65_1602	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BD65_1609	COG3501	Rhs element vgr protein
BD65_161	COG3381	protein complex oligomerization
BD65_1622	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BD65_1624	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BD65_1633	COG0138	bifunctional purine biosynthesis protein purh
BD65_1634	COG0151	Belongs to the GarS family
BD65_1636	COG0776	regulation of translation
BD65_1637	COG3068	Protein conserved in bacteria
BD65_1638	COG1515	deoxyribonuclease V activity
BD65_1639	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BD65_164	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BD65_1640	COG2816	NAD+ diphosphatase activity
BD65_1641	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
BD65_1642	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BD65_1644	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BD65_1645	COG2104	thiamine diphosphate biosynthetic process
BD65_1646	COG2022	thiamine diphosphate biosynthetic process
BD65_1648	COG0823	Involved in the tonB-independent uptake of proteins
BD65_1649	COG0823	Involved in the tonB-independent uptake of proteins
BD65_1650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BD65_1651	COG0085	RNA polymerase activity
BD65_1652	COG0222	ribosome binding
BD65_1653	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BD65_1655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BD65_1656	COG0250	Participates in transcription elongation, termination and antitermination
BD65_1657	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BD65_166	COG0673	inositol 2-dehydrogenase activity
BD65_1666	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BD65_1672	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
BD65_1673	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BD65_1674	COG1739	Uncharacterized protein family UPF0029
BD65_1676	COG1250	3-hydroxyacyl-CoA dehydrogenase
BD65_1676	COG1024	Enoyl-CoA hydratase
BD65_1678	COG0543	2 iron, 2 sulfur cluster binding
BD65_1681	COG0250	Participates in transcription elongation, termination and antitermination
BD65_1684	COG0805	protein transport
BD65_1686	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BD65_1687	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BD65_1688	COG3165	ubiquinone biosynthetic process from chorismate
BD65_1689	COG2226	methyltransferase
BD65_1690	COG1322	Protein conserved in bacteria
BD65_1691	COG0586	Pfam SNARE associated Golgi protein
BD65_1692	COG1966	Carbon starvation protein
BD65_1695	COG0412	Dienelactone hydrolase
BD65_1696	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BD65_1698	COG0583	DNA-binding transcription factor activity
BD65_1699	COG0584	glycerophosphoryl diester phosphodiesterase
BD65_17	COG1289	transmembrane transporter activity
BD65_1701	COG0395	ABC-type sugar transport system, permease component
BD65_1702	COG1175	transmembrane transport
BD65_1703	COG1653	transport
BD65_1710	COG0410	ABC transporter
BD65_1711	COG0411	ABC transporter
BD65_1712	COG4177	L-phenylalanine transmembrane transporter activity
BD65_1713	COG0559	Belongs to the binding-protein-dependent transport system permease family
BD65_1715	COG1929	Belongs to the glycerate kinase type-1 family
BD65_1717	COG2610	gluconate transmembrane transporter activity
BD65_1718	COG3835	regulator
BD65_172	COG3102	Protein conserved in bacteria
BD65_1720	COG2177	Part of the ABC transporter FtsEX involved in
BD65_1721	COG2884	Cell division ATP-binding protein ftsE
BD65_1722	COG0552	protein localization to endoplasmic reticulum
BD65_1722	COG0552	protein localization to endoplasmic reticulum
BD65_1723	COG0742	ribosomal rna small subunit methyltransferase
BD65_1724	COG3776	membrane
BD65_1727	COG3714	YhhN family
BD65_173	COG3142	Participates in the control of copper homeostasis
BD65_1730	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BD65_1732	COG0247	lactate metabolic process
BD65_1734	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BD65_1735	COG2271	Major facilitator Superfamily
BD65_1736	COG0584	glycerophosphoryl diester phosphodiesterase
BD65_1737	COG0561	phosphatase activity
BD65_1738	COG2267	carboxylic ester hydrolase activity
BD65_1739	COG1280	lysine exporter protein (LysE YggA)
BD65_1740	COG0514	ATP-dependent DNA helicase (RecQ)
BD65_1741	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
BD65_1742	COG2050	protein possibly involved in aromatic compounds catabolism
BD65_1744	COG0598	Magnesium transport protein CorA
BD65_1746	COG5564	TIM-barrel signal transduction protein
BD65_1747	COG5441	Belongs to the UPF0261 family
BD65_1749	COG0210	DNA helicase
BD65_1750	COG1011	Hydrolase
BD65_1751	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BD65_1752	COG3159	Protein conserved in bacteria
BD65_1753	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BD65_1754	COG5567	small periplasmic lipoprotein
BD65_1756	COG3072	Adenylate cyclase
BD65_1757	COG0181	hydroxymethylbilane synthase activity
BD65_1758	COG1587	Uroporphyrinogen-III synthase
BD65_1759	COG2959	enzyme of heme biosynthesis
BD65_176	COG3788	relative of glutathione S-transferase, MAPEG superfamily
BD65_1760	COG3071	HemY protein
BD65_1766	COG1113	amino acid transport
BD65_177	COG1801	Protein of unknown function DUF72
BD65_1770	COG2244	polysaccharide biosynthetic process
BD65_1771	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BD65_1772	COG0456	acetyltransferase
BD65_1773	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BD65_1774	COG1088	dTDP-glucose 4,6-dehydratase activity
BD65_1775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BD65_1776	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BD65_1777	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
BD65_1778	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BD65_1779	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BD65_178	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BD65_1780	COG3118	belongs to the thioredoxin family
BD65_1782	COG0248	Ppx GppA phosphatase
BD65_1784	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BD65_1786	COG0583	DNA-binding transcription factor activity
BD65_1787	COG3397	chitin binding
BD65_1789	COG0129	dihydroxy-acid dehydratase activity
BD65_179	COG0494	nUDIX hydrolase
BD65_1790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BD65_1791	COG3978	acetolactate synthase activity
BD65_1793	COG0606	chelatase, subunit chli
BD65_1794	COG3085	chromosome segregation
BD65_1795	COG0583	DNA-binding transcription factor activity
BD65_18	COG3304	Inner membrane component domain
BD65_181	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BD65_1811	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BD65_1812	COG0678	peroxiredoxin activity
BD65_1812	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BD65_1813	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BD65_1821	COG1629	transport
BD65_1822	COG0165	Argininosuccinate lyase
BD65_1823	COG0137	argininosuccinate synthase activity
BD65_1824	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BD65_1825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BD65_183	COG2255	four-way junction helicase activity
BD65_1834	COG0527	aspartate kinase activity
BD65_1834	COG0460	homoserine dehydrogenase
BD65_1835	COG0626	cystathionine gamma-synthase activity
BD65_1836	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
BD65_1838	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BD65_1839	COG1609	Transcriptional regulator
BD65_184	COG3104	oligopeptide transport
BD65_1840	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BD65_1841	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BD65_1843	COG1575	Belongs to the MenA family. Type 1 subfamily
BD65_1844	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BD65_1845	COG3074	FtsZ-dependent cytokinesis
BD65_1846	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BD65_1847	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BD65_1848	COG1494	fructose-1,6-bisphosphatase
BD65_1849	COG2814	Major facilitator Superfamily
BD65_185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BD65_1851	COG3152	Membrane
BD65_1854	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BD65_1856	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BD65_186	COG1121	(ABC) transporter
BD65_1864	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BD65_187	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BD65_188	COG0739	heme binding
BD65_1882	COG4695	Portal protein
BD65_189	COG1560	Kdo2-lipid A biosynthetic process
BD65_1899	COG3678	ATP-independent chaperone mediated protein folding
BD65_19	COG0210	DNA helicase
BD65_190	COG0469	pyruvate kinase activity
BD65_1900	COG0745	RESPONSE REGULATOR receiver
BD65_1901	COG2205	protein histidine kinase activity
BD65_1902	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BD65_1903	COG1045	serine acetyltransferase
BD65_1904	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BD65_1905	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BD65_1906	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BD65_1907	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BD65_1908	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BD65_1909	COG4942	peptidase
BD65_191	COG1737	Transcriptional regulator
BD65_1910	COG2861	carbohydrate metabolic process
BD65_1913	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BD65_1914	COG0859	PFAM glycosyl transferase family 9
BD65_1915	COG0859	PFAM glycosyl transferase family 9
BD65_1916	COG1519	Transferase
BD65_192	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BD65_1920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BD65_1921	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BD65_1922	COG2003	Belongs to the UPF0758 family
BD65_1923	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BD65_1924	COG0756	dUTP diphosphatase activity
BD65_1925	COG1309	transcriptional regulator
BD65_1926	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BD65_1927	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BD65_1928	COG1561	YicC-like family, N-terminal region
BD65_193	COG0800	Aldolase
BD65_1931	COG5001	Diguanylate cyclase
BD65_1932	COG1024	Enoyl-CoA hydratase
BD65_1933	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BD65_1934	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BD65_1935	COG2860	membrane
BD65_1936	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BD65_1938	COG1758	RNA polymerase activity
BD65_1939	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BD65_1940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BD65_1941	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BD65_1942	COG0786	glutamate:sodium symporter activity
BD65_1943	COG2233	PERMEase
BD65_1944	COG2982	Protein involved in outer membrane biogenesis
BD65_1945	COG0456	acetyltransferase
BD65_1948	COG1011	Hydrolase
BD65_195	COG2076	Multidrug Resistance protein
BD65_1950	COG0174	glutamine synthetase
BD65_1951	COG3852	Histidine kinase
BD65_1953	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BD65_1955	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BD65_1956	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BD65_1956	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BD65_1957	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BD65_1958	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BD65_1959	COG3084	Protein conserved in bacteria
BD65_196	COG0251	oxidation-reduction process
BD65_1961	COG1763	Mo-molybdopterin cofactor biosynthetic process
BD65_1966	COG2186	Transcriptional regulator
BD65_1967	COG1609	Transcriptional regulator
BD65_1968	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BD65_1969	COG1879	ABC-type sugar transport system periplasmic component
BD65_197	COG1199	ATP-dependent helicase activity
BD65_1970	COG1172	Belongs to the binding-protein-dependent transport system permease family
BD65_1971	COG1129	ABC transporter
BD65_1972	COG1869	D-ribose catabolic process
BD65_1973	COG3158	transport of potassium into the cell
BD65_1974	COG0714	Associated with various cellular activities
BD65_1975	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BD65_1977	COG2502	aspartate--ammonia ligase
BD65_1978	COG1522	sequence-specific DNA binding
BD65_1979	COG0716	FMN binding
BD65_198	COG1214	PFAM Peptidase M22, glycoprotease
BD65_1980	COG0445	tRNA wobble uridine modification
BD65_1981	COG0357	Ribosomal RNA small subunit methyltransferase G
BD65_1982	COG3312	ion transport
BD65_1983	COG0356	it plays a direct role in the translocation of protons across the membrane
BD65_1985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BD65_1987	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BD65_1988	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BD65_1989	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BD65_199	COG3065	identical protein binding
BD65_1990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BD65_1992	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BD65_1993	COG1943	Transposase
BD65_1996	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BD65_1997	COG0573	inorganic phosphate transmembrane transporter activity
BD65_1998	COG0581	inorganic phosphate transmembrane transporter activity
BD65_2	COG0167	dihydroorotate dehydrogenase activity
BD65_20	COG1803	Methylglyoxal synthase
BD65_200	COG0318	PFAM AMP-dependent synthetase and ligase
BD65_2000	COG0704	Plays a role in the regulation of phosphate uptake
BD65_2001	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD65_2002	COG0765	amino acid transport
BD65_2003	COG0765	amino acid transport
BD65_2004	COG2252	PERMEase
BD65_2005	COG0840	transmembrane signaling receptor activity
BD65_2007	COG3121	Chaperone
BD65_201	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BD65_2012	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BD65_2013	COG0706	membrane insertase activity
BD65_2015	COG0594	ribonuclease P activity
BD65_2016	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BD65_2018	COG0592	DNA-directed DNA polymerase activity
BD65_202	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BD65_2020	COG0187	DNA topoisomerase II activity
BD65_2021	COG0561	phosphatase activity
BD65_2022	COG0823	Involved in the tonB-independent uptake of proteins
BD65_2023	COG5645	(Lipo)protein
BD65_2026	COG2985	domain, Protein
BD65_2026	COG0569	domain protein
BD65_2027	COG3977	Valine--pyruvate aminotransferase
BD65_2028	COG2885	chlorophyll binding
BD65_203	COG2894	cell division
BD65_2032	COG2818	Glycosylase
BD65_204	COG0850	regulation of cytokinetic process
BD65_2042	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BD65_2042	COG2213	PTS system mannitol-specific
BD65_2044	COG3722	fumarate hydratase activity
BD65_2046	COG2258	MOSC domain
BD65_2047	COG0840	transmembrane signaling receptor activity
BD65_2048	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BD65_205	COG3100	YcgL domain-containing protein
BD65_2050	COG3383	formate dehydrogenase (NAD+) activity
BD65_2050	COG0243	molybdopterin cofactor binding
BD65_2051	COG0243	molybdopterin cofactor binding
BD65_2051	COG3383	formate dehydrogenase (NAD+) activity
BD65_2052	COG0437	4 iron, 4 sulfur cluster binding
BD65_2053	COG2864	formate dehydrogenase
BD65_2055	COG1921	L-seryl-tRNASec selenium transferase activity
BD65_2056	COG3276	selenocysteine insertion sequence binding
BD65_2057	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BD65_2059	COG3274	enterobacterial common antigen metabolic process
BD65_206	COG0179	Fumarylacetoacetate (FAA) hydrolase
BD65_2060	COG3344	reverse transcriptase
BD65_2063	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BD65_2064	COG2986	histidine ammonia-lyase
BD65_2069	COG2194	sulfuric ester hydrolase activity
BD65_207	COG0582	viral genome integration into host DNA
BD65_2070	COG2197	response regulator
BD65_2071	COG3851	Histidine kinase
BD65_2072	COG2271	Major facilitator Superfamily
BD65_2074	COG0747	negative chemotaxis
BD65_2075	COG0601	transmembrane transport
BD65_2076	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BD65_2077	COG0444	Belongs to the ABC transporter superfamily
BD65_2078	COG4608	Belongs to the ABC transporter superfamily
BD65_2079	COG2194	sulfuric ester hydrolase activity
BD65_208	COG2983	Belongs to the UPF0260 family
BD65_2084	COG1215	transferase activity, transferring glycosyl groups
BD65_2085	COG1215	transferase activity, transferring glycosyl groups
BD65_2086	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BD65_2087	COG0457	Tetratricopeptide repeat
BD65_2087	COG3118	belongs to the thioredoxin family
BD65_2088	COG2199	diguanylate cyclase activity
BD65_2088	COG2200	EAL domain
BD65_2089	COG1301	dicarboxylic acid transport
BD65_2090	COG0612	Peptidase, M16
BD65_2091	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BD65_2092	COG1942	4-Oxalocrotonate Tautomerase
BD65_2093	COG2200	EAL domain
BD65_2094	COG2134	cdp-diacylglycerol pyrophosphatase
BD65_2095	COG1295	ribonuclease BN
BD65_2097	COG1301	dicarboxylic acid transport
BD65_2098	COG0626	cystathionine gamma-synthase activity
BD65_2099	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BD65_2100	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BD65_2101	COG0339	signal peptide processing
BD65_2102	COG0742	ribosomal rna small subunit methyltransferase
BD65_2104	COG0589	response to stress
BD65_2106	COG0306	phosphate transporter
BD65_2107	COG2081	HI0933 family
BD65_2109	COG1247	-acetyltransferase
BD65_211	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BD65_2110	COG1741	Belongs to the pirin family
BD65_2111	COG1609	Transcriptional regulator
BD65_2112	COG2610	gluconate transmembrane transporter activity
BD65_2113	COG3265	gluconokinase activity
BD65_2114	COG2095	MarC family integral membrane protein
BD65_2115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BD65_2116	COG3275	phosphorelay sensor kinase activity
BD65_2117	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BD65_2118	COG1523	belongs to the glycosyl hydrolase 13 family
BD65_2119	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BD65_2120	COG0297	glycogen (starch) synthase activity
BD65_2121	COG0058	SHG alpha-glucan phosphorylase activity
BD65_2122	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BD65_2123	COG1349	DNA-binding transcription factor activity
BD65_2124	COG0705	Rhomboid family
BD65_2126	COG2909	trisaccharide binding
BD65_2127	COG0058	SHG alpha-glucan phosphorylase activity
BD65_2128	COG1640	4-alpha-glucanotransferase
BD65_213	COG2719	SpoVR family
BD65_2130	COG1040	competence protein
BD65_2131	COG0596	Alpha beta hydrolase
BD65_2135	COG1918	ferrous iron import across plasma membrane
BD65_2136	COG2183	response to ionizing radiation
BD65_214	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BD65_2142	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BD65_2143	COG0745	RESPONSE REGULATOR receiver
BD65_2145	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BD65_2147	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BD65_2148	COG1011	Hydrolase
BD65_215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BD65_2150	COG0494	nUDIX hydrolase
BD65_2151	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BD65_2156	COG4796	Type ii and iii secretion system protein
BD65_2157	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BD65_216	COG2814	Major facilitator Superfamily
BD65_2161	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BD65_2163	COG0180	Tryptophanyl-tRNA synthetase
BD65_2164	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BD65_2164	COG1648	precorrin-2 dehydrogenase activity
BD65_2166	COG2146	nitrite reductase [NAD(P)H] activity
BD65_2167	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BD65_2168	COG0402	S-adenosylhomocysteine deaminase activity
BD65_2169	COG0738	Major facilitator superfamily
BD65_2172	COG1609	Transcriptional regulator
BD65_2173	COG1486	melibiose metabolic process
BD65_2174	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BD65_2177	COG1289	transmembrane transporter activity
BD65_2178	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BD65_2179	COG1765	OsmC-like protein
BD65_218	COG2199	diguanylate cyclase activity
BD65_218	COG2200	EAL domain
BD65_218	COG2202	Pas domain
BD65_2183	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BD65_2184	COG3954	Phosphoribulokinase
BD65_2186	COG0429	hydrolase of the alpha beta-hydrolase fold
BD65_2188	COG0859	PFAM glycosyl transferase family 9
BD65_2189	COG1216	Glycosyl transferase, family 2
BD65_2190	COG0488	(ABC) transporter
BD65_2191	COG2249	NAD(P)H dehydrogenase (quinone) activity
BD65_2193	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
BD65_2194	COG1047	Peptidyl-prolyl cis-trans
BD65_2196	COG0545	Peptidyl-prolyl cis-trans isomerase
BD65_2197	COG2964	Protein conserved in bacteria
BD65_2199	COG2923	Belongs to the DsrF TusC family
BD65_22	COG1832	CoA-binding protein
BD65_2200	COG2168	tRNA wobble position uridine thiolation
BD65_2201	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BD65_2202	COG0049	tRNA binding
BD65_2204	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BD65_2207	COG0051	transcription antitermination factor activity, RNA binding
BD65_2208	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BD65_2210	COG0089	rRNA binding
BD65_2211	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BD65_2212	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BD65_2213	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BD65_2214	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BD65_2215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BD65_2216	COG0255	Belongs to the universal ribosomal protein uL29 family
BD65_2217	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BD65_2218	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BD65_222	COG2718	Belongs to the UPF0229 family
BD65_2220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BD65_2225	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BD65_2226	COG1841	ribosomal large subunit assembly
BD65_2227	COG0200	Binds to the 23S rRNA
BD65_2228	COG0201	protein transport
BD65_2229	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BD65_223	COG2766	serine protein kinase
BD65_2230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BD65_2232	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BD65_2234	COG0203	ribosomal protein L17
BD65_2235	COG0789	Transcriptional regulator
BD65_2236	COG3036	rescue of stalled ribosome
BD65_2237	COG1970	mechanosensitive ion channel activity
BD65_2238	COG0569	domain protein
BD65_2239	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BD65_2239	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BD65_224	COG3713	MltA-interacting MipA family protein
BD65_2240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BD65_2241	COG0242	peptide deformylase activity
BD65_2242	COG0758	DNA mediated transformation
BD65_2244	COG0551	DNA topoisomerase type I activity
BD65_2245	COG0009	L-threonylcarbamoyladenylate synthase
BD65_2247	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BD65_225	COG2194	sulfuric ester hydrolase activity
BD65_2252	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BD65_2253	COG3162	membrane
BD65_2254	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BD65_2255	COG1301	dicarboxylic acid transport
BD65_2257	COG1309	transcriptional regulator
BD65_2258	COG4232	protein-disulfide reductase activity
BD65_2260	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BD65_2266	COG1509	lysine 2,3-aminomutase activity
BD65_2268	COG3397	chitin binding
BD65_2272	COG3188	usher protein
BD65_2274	COG2076	Multidrug Resistance protein
BD65_2276	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BD65_2277	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BD65_2278	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BD65_2279	COG1053	succinate dehydrogenase
BD65_228	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BD65_2280	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BD65_2281	COG3264	Mechanosensitive ion channel
BD65_2281	COG1511	domain protein
BD65_2282	COG0688	phosphatidylethanolamine metabolic process
BD65_2283	COG1162	GTPase activity
BD65_2284	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BD65_2288	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BD65_2289	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BD65_2289	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BD65_229	COG3139	Protein of unknown function (DUF1315)
BD65_2290	COG0802	atpase or kinase
BD65_2293	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BD65_2294	COG1923	regulation of RNA biosynthetic process
BD65_2295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BD65_2296	COG0330	HflC and HflK could
BD65_2297	COG0330	HflC and HflK could
BD65_2298	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BD65_2299	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BD65_23	COG3785	DNA binding
BD65_230	COG1335	isochorismatase
BD65_2300	COG1959	2 iron, 2 sulfur cluster binding
BD65_2301	COG0557	exoribonuclease II activity
BD65_2302	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BD65_2306	COG3121	Chaperone
BD65_2307	COG3188	usher protein
BD65_231	COG0252	asparaginase activity
BD65_2311	COG1073	alpha beta
BD65_2313	COG0360	Binds together with S18 to 16S ribosomal RNA
BD65_2315	COG0359	binds to the 23S rRNA
BD65_2316	COG3061	Opacity-associated protein A
BD65_2317	COG0545	Peptidyl-prolyl cis-trans isomerase
BD65_2319	COG0737	Belongs to the 5'-nucleotidase family
BD65_232	COG0616	signal peptide processing
BD65_2320	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BD65_2321	COG1218	3'(2'),5'-bisphosphate nucleotidase
BD65_2323	COG1253	flavin adenine dinucleotide binding
BD65_2324	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BD65_2325	COG0729	surface antigen
BD65_2326	COG2911	Protein conserved in bacteria
BD65_2327	COG2105	PFAM AIG2 family protein
BD65_2328	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BD65_233	COG0778	Nitroreductase
BD65_2330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BD65_2333	COG3423	Transcriptional regulator
BD65_2336	COG0142	geranyltranstransferase activity
BD65_2339	COG0697	spore germination
BD65_2340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BD65_2341	COG0642	Histidine kinase
BD65_2342	COG0745	RESPONSE REGULATOR receiver
BD65_2343	COG2027	D-alanyl-D-alanine carboxypeptidase
BD65_2344	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BD65_2345	COG1534	Rna-binding protein
BD65_2346	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BD65_2347	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BD65_2348	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BD65_2349	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BD65_235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BD65_2350	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BD65_2354	COG0195	Participates in both transcription termination and antitermination
BD65_2356	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BD65_2359	COG1185	polyribonucleotide nucleotidyltransferase activity
BD65_236	COG0494	nUDIX hydrolase
BD65_2361	COG0513	Belongs to the DEAD box helicase family
BD65_2362	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BD65_2363	COG0814	amino acid
BD65_2368	COG2827	Endonuclease containing a URI domain
BD65_2369	COG3153	acetyltransferase
BD65_2370	COG0531	amino acid
BD65_2371	COG1982	Orn Lys Arg decarboxylase major
BD65_2373	COG3787	Belongs to the UPF0306 family
BD65_2374	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BD65_2375	COG0702	epimerase
BD65_2376	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
BD65_2377	COG3454	Phosphonate metabolism
BD65_2378	COG4778	phosphonate C-P lyase system protein PhnL
BD65_2379	COG4107	phosphonate C-P lyase system protein PhnK
BD65_238	COG0708	Exodeoxyribonuclease III
BD65_2380	COG3627	carbon phosphorus lyase activity
BD65_2381	COG3626	phosphonate metabolism
BD65_2382	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
BD65_2383	COG3624	Phosphonate C-P lyase system protein PhnG
BD65_2387	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BD65_2388	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
BD65_2391	COG2927	DNA polymerase III (CHI subunit)
BD65_2392	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BD65_2393	COG0795	lipopolysaccharide-transporting ATPase activity
BD65_2394	COG0795	lipopolysaccharide-transporting ATPase activity
BD65_2396	COG0582	viral genome integration into host DNA
BD65_24	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BD65_2410	COG2963	transposase activity
BD65_2411	COG2801	Transposase and inactivated derivatives
BD65_2412	COG2801	Transposase and inactivated derivatives
BD65_2415	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BD65_2422	COG0582	viral genome integration into host DNA
BD65_2427	COG2963	transposase activity
BD65_2429	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BD65_243	COG0788	formyltetrahydrofolate deformylase activity
BD65_2430	COG5492	domain, Protein
BD65_2434	COG3119	arylsulfatase activity
BD65_2435	COG1349	DNA-binding transcription factor activity
BD65_2437	COG2222	sugar isomerase
BD65_2438	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BD65_2439	COG3715	PTS system
BD65_2440	COG3716	PTS system mannose fructose sorbose family IID component
BD65_2442	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BD65_2444	COG1028	Short-chain dehydrogenase reductase Sdr
BD65_2446	COG0641	radical SAM
BD65_2447	COG3119	arylsulfatase activity
BD65_2449	COG0191	fructose-bisphosphate aldolase activity
BD65_245	COG1752	Esterase of the alpha-beta hydrolase superfamily
BD65_2452	COG0859	PFAM glycosyl transferase family 9
BD65_2454	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BD65_2455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BD65_2457	COG2376	Dihydroxyacetone kinase
BD65_2458	COG1461	Dihydroxyacetone kinase
BD65_2459	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BD65_2459	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BD65_2459	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BD65_246	COG0745	RESPONSE REGULATOR receiver
BD65_2461	COG3706	GGDEF domain
BD65_2467	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
BD65_2470	COG2823	Periplasmic or secreted lipoprotein
BD65_2472	COG4667	esterase of the alpha-beta hydrolase superfamily
BD65_2473	COG0084	hydrolase, TatD family'
BD65_2474	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BD65_2475	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BD65_2477	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BD65_2479	COG3726	membrane protein affecting hemolysin expression
BD65_2480	COG0560	Phosphoserine phosphatase
BD65_2483	COG0488	(ABC) transporter
BD65_2485	COG0741	lytic transglycosylase activity
BD65_2486	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
BD65_2487	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BD65_2488	COG2207	Transcriptional regulator
BD65_2488	COG3708	Transcriptional regulator
BD65_2489	COG0406	alpha-ribazole phosphatase activity
BD65_249	COG1435	thymidine kinase activity
BD65_2490	COG3045	CreA protein
BD65_2491	COG0745	RESPONSE REGULATOR receiver
BD65_2493	COG0083	homoserine kinase activity
BD65_2496	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BD65_2497	COG0521	Mo-molybdopterin cofactor biosynthetic process
BD65_2498	COG0477	Major facilitator Superfamily
BD65_25	COG1254	Belongs to the acylphosphatase family
BD65_250	COG1454	alcohol dehydrogenase
BD65_250	COG1012	belongs to the aldehyde dehydrogenase family
BD65_2500	COG1584	GPR1 FUN34 yaaH family protein
BD65_2501	COG0443	Heat shock 70 kDa protein
BD65_2503	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BD65_2504	COG0583	DNA-binding transcription factor activity
BD65_2506	COG0196	riboflavin kinase activity
BD65_2508	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BD65_2509	COG1047	Peptidyl-prolyl cis-trans
BD65_251	COG2095	MarC family integral membrane protein
BD65_2510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BD65_2512	COG0505	Belongs to the CarA family
BD65_2513	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BD65_2514	COG1280	lysine exporter protein (LysE YggA)
BD65_2516	COG2966	Psort location CytoplasmicMembrane, score
BD65_252	COG4166	transmembrane transport
BD65_2521	COG2967	ApaG domain
BD65_2522	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BD65_2523	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BD65_2524	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BD65_2525	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BD65_2527	COG0564	pseudouridine synthase activity
BD65_2528	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BD65_2529	COG0417	DNA replication proofreading
BD65_2531	COG0586	Pfam SNARE associated Golgi protein
BD65_2532	COG1178	ABC-type Fe3 transport system permease component
BD65_2533	COG4143	(ABC) transporter
BD65_2536	COG2814	Major facilitator Superfamily
BD65_2538	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BD65_2539	COG0473	3-isopropylmalate dehydrogenase activity
BD65_2542	COG1022	Amp-dependent synthetase and ligase
BD65_2543	COG0028	Belongs to the TPP enzyme family
BD65_2545	COG1609	Transcriptional regulator
BD65_2548	COG0275	rRNA processing
BD65_2549	COG3116	cell division
BD65_255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BD65_2550	COG0768	penicillin binding
BD65_2551	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BD65_2552	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BD65_2555	COG0772	Belongs to the SEDS family
BD65_2556	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BD65_2559	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BD65_2560	COG0849	cell division
BD65_2561	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BD65_2566	COG0494	nUDIX hydrolase
BD65_2569	COG0237	dephospho-CoA kinase activity
BD65_2570	COG0516	GMP reductase activity
BD65_2571	COG1459	type II secretion system
BD65_2572	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BD65_2573	COG4969	Belongs to the N-Me-Phe pilin family
BD65_2576	COG3725	Membrane protein required for beta-lactamase induction
BD65_2578	COG1113	amino acid transport
BD65_2579	COG2186	Transcriptional regulator
BD65_258	COG3099	Belongs to the UPF0263 family
BD65_2580	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BD65_2581	COG0508	dehydrogenase complex catalyzes the overall conversion of
BD65_2582	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BD65_2584	COG1049	propionate catabolic process, 2-methylcitrate cycle
BD65_2585	COG3112	Uncharacterised protein family (UPF0231)
BD65_2588	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BD65_259	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BD65_2590	COG2132	Multicopper oxidase
BD65_2592	COG0288	reversible hydration of carbon dioxide
BD65_2593	COG1131	(ABC) transporter
BD65_2594	COG0842	Transport permease protein
BD65_2595	COG0726	polysaccharide deacetylase
BD65_2596	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BD65_2597	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BD65_2598	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BD65_2599	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BD65_26	COG2920	part of a sulfur-relay system
BD65_2600	COG0617	tRNA 3'-terminal CCA addition
BD65_2602	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BD65_2603	COG1489	DNA binding
BD65_2604	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BD65_2605	COG1643	Atp-dependent helicase
BD65_2606	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BD65_2609	COG0316	Belongs to the HesB IscA family
BD65_2610	COG2860	membrane
BD65_2612	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BD65_2613	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BD65_2614	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BD65_2616	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BD65_2617	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BD65_2618	COG3956	TIGRFAM MazG family protein
BD65_2619	COG0504	CTP synthase activity
BD65_2621	COG0602	queuosine metabolic process
BD65_2622	COG0720	synthase
BD65_2623	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BD65_2625	COG0175	sulfate reduction
BD65_2628	COG2234	aminopeptidase activity
BD65_2629	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BD65_2629	COG1648	precorrin-2 dehydrogenase activity
BD65_263	COG2350	Protein conserved in bacteria
BD65_2630	COG0175	sulfate reduction
BD65_2631	COG2895	sulfate adenylyltransferase (ATP) activity
BD65_2632	COG0529	Catalyzes the synthesis of activated sulfate
BD65_2634	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BD65_2636	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BD65_2637	COG0585	pseudouridine synthase activity
BD65_2638	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BD65_2640	COG4942	peptidase
BD65_2640	COG1388	LysM domain
BD65_2641	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BD65_2642	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BD65_2649	COG3547	Transposase (IS116 IS110 IS902 family)
BD65_2651	COG2826	transposase and inactivated derivatives, IS30 family
BD65_2653	COG2205	protein histidine kinase activity
BD65_2653	COG0784	Response regulator, receiver
BD65_2657	COG0741	lytic transglycosylase activity
BD65_266	COG3710	Transcriptional regulator
BD65_2668	COG4789	Type iii secretion
BD65_2670	COG1157	protein secretion by the type III secretion system
BD65_2683	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BD65_2687	COG3397	chitin binding
BD65_2689	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BD65_2696	COG2165	general secretion pathway protein
BD65_2700	COG3031	protein transport across the cell outer membrane
BD65_2706	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BD65_2706	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BD65_2707	COG0477	Major facilitator Superfamily
BD65_2709	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BD65_2710	COG2137	regulation of response to DNA damage stimulus
BD65_2711	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BD65_2712	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BD65_2717	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BD65_2718	COG1238	metal cluster binding
BD65_2719	COG2918	glutathione biosynthetic process
BD65_2720	COG1854	S-ribosylhomocysteine lyase activity
BD65_2721	COG4536	flavin adenine dinucleotide binding
BD65_2722	COG4137	Cytochrome C assembly protein
BD65_2723	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BD65_2724	COG0228	four-way junction DNA binding
BD65_2725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BD65_2726	COG0336	Belongs to the RNA methyltransferase TrmD family
BD65_2727	COG0335	large ribosomal subunit rRNA binding
BD65_2728	COG3137	Salt-induced outer membrane protein
BD65_2729	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BD65_273	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BD65_2730	COG3279	Response regulator of the LytR AlgR family
BD65_2731	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BD65_2732	COG1605	Chorismate mutase
BD65_2732	COG0287	Prephenate dehydrogenase
BD65_2733	COG0077	Prephenate dehydratase
BD65_2733	COG1605	Chorismate mutase
BD65_2734	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BD65_2735	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BD65_2736	COG0564	pseudouridine synthase activity
BD65_2738	COG0542	response to heat
BD65_274	COG1607	acyl-coa hydrolase
BD65_2747	COG3021	interspecies interaction between organisms
BD65_2748	COG0741	lytic transglycosylase activity
BD65_2748	COG1388	LysM domain
BD65_2750	COG2226	methyltransferase
BD65_2752	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BD65_2754	COG1960	acyl-CoA dehydrogenase activity
BD65_2755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BD65_2756	COG3034	peptidoglycan biosynthetic process
BD65_2757	COG0121	glutamine amidotransferase
BD65_2758	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BD65_2759	COG1805	sodium ion transport
BD65_2760	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BD65_2761	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BD65_2762	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BD65_2764	COG1477	protein flavinylation
BD65_2765	COG2991	Protein conserved in bacteria
BD65_2767	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BD65_2768	COG2195	Cleaves the N-terminal amino acid of tripeptides
BD65_2769	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BD65_2780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BD65_2784	COG4126	flavin adenine dinucleotide binding
BD65_2786	COG2974	May be involved in recombination
BD65_2787	COG1940	carbohydrate kinase activity
BD65_2788	COG0419	ATPase involved in DNA repair
BD65_2789	COG0420	3'-5' exonuclease activity
BD65_279	COG3047	cAMP biosynthetic process
BD65_2790	COG0745	RESPONSE REGULATOR receiver
BD65_2791	COG5002	protein histidine kinase activity
BD65_2793	COG1114	Component of the transport system for branched-chain amino acids
BD65_2794	COG1113	amino acid transport
BD65_2795	COG0366	Alpha amylase catalytic
BD65_2796	COG0300	oxidoreductase activity
BD65_2797	COG0450	alkyl hydroperoxide reductase
BD65_2798	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
BD65_2799	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BD65_2801	COG1862	Preprotein translocase
BD65_2802	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BD65_2803	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BD65_2804	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BD65_2805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BD65_2805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BD65_2806	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BD65_2808	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BD65_2809	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BD65_2810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BD65_2811	COG0142	geranyltranstransferase activity
BD65_2816	COG1840	ABC-type Fe3 transport system, periplasmic component
BD65_2818	COG0693	protein deglycase activity
BD65_2819	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BD65_282	COG0133	tryptophan synthase activity
BD65_2820	COG1666	GTP binding
BD65_2821	COG2814	Major facilitator Superfamily
BD65_2823	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BD65_2824	COG1845	cytochrome c oxidase, subunit III
BD65_2825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BD65_2826	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BD65_2828	COG2223	nitrite transmembrane transporter activity
BD65_2829	COG3056	Lipoprotein
BD65_283	COG0135	phosphoribosylanthranilate isomerase activity
BD65_283	COG0134	indole-3-glycerol-phosphate synthase activity
BD65_2830	COG0271	Belongs to the BolA IbaG family
BD65_2832	COG0740	serine-type endopeptidase activity
BD65_2833	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BD65_2834	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BD65_2835	COG0776	regulation of translation
BD65_2836	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BD65_2837	COG1555	photosystem II stabilization
BD65_2838	COG0824	Thioesterase
BD65_2839	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BD65_2840	COG4533	DNA binding
BD65_2843	COG1522	sequence-specific DNA binding
BD65_2844	COG1132	(ABC) transporter
BD65_2845	COG1132	(ABC) transporter
BD65_2846	COG0347	Belongs to the P(II) protein family
BD65_2847	COG0004	ammonium transporteR
BD65_2848	COG1946	Acyl-CoA thioesterase
BD65_2849	COG3695	enzyme binding
BD65_285	COG0512	Glutamine amidotransferase of anthranilate synthase
BD65_2853	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BD65_2854	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BD65_2855	COG1309	transcriptional regulator
BD65_2856	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BD65_2857	COG3264	Mechanosensitive ion channel
BD65_2857	COG1196	nuclear chromosome segregation
BD65_2860	COG2832	Protein of unknown function (DUF454)
BD65_2861	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BD65_2866	COG0642	Histidine kinase
BD65_2867	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BD65_2869	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BD65_287	COG0613	PHP domain protein
BD65_2871	COG0326	Molecular chaperone. Has ATPase activity
BD65_2874	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
BD65_2875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BD65_2876	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BD65_2876	COG4651	solute:proton antiporter activity
BD65_2878	COG0737	Belongs to the 5'-nucleotidase family
BD65_2879	COG2963	transposase activity
BD65_288	COG0009	L-threonylcarbamoyladenylate synthase
BD65_2881	COG0500	methyltransferase
BD65_2887	COG1086	Polysaccharide biosynthesis protein
BD65_289	COG1187	pseudouridine synthase activity
BD65_2891	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BD65_2892	COG3735	TraB family
BD65_2893	COG2217	Heavy metal translocating P-type atpase
BD65_2894	COG0789	Transcriptional regulator
BD65_2895	COG1585	Membrane protein implicated in regulation of membrane protease activity
BD65_2896	COG0330	HflC and HflK could
BD65_2897	COG3118	belongs to the thioredoxin family
BD65_2898	COG0300	oxidoreductase activity
BD65_2899	COG2755	lipolytic protein G-D-S-L family
BD65_29	COG0288	reversible hydration of carbon dioxide
BD65_2900	COG4181	ATPase activity
BD65_2901	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BD65_2902	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BD65_2903	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BD65_2904	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BD65_2905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BD65_291	COG1028	Short-chain dehydrogenase reductase Sdr
BD65_2911	COG3188	usher protein
BD65_2912	COG3121	Chaperone
BD65_2918	COG2501	S4 domain
BD65_2919	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BD65_292	COG0616	signal peptide processing
BD65_2921	COG0582	viral genome integration into host DNA
BD65_2922	COG2963	transposase activity
BD65_2923	COG3344	reverse transcriptase
BD65_2927	COG2963	transposase activity
BD65_2930	COG0318	PFAM AMP-dependent synthetase and ligase
BD65_2935	COG3038	cytochrome b561
BD65_2937	COG0058	SHG alpha-glucan phosphorylase activity
BD65_2939	COG0745	RESPONSE REGULATOR receiver
BD65_294	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BD65_2941	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BD65_2943	COG1215	transferase activity, transferring glycosyl groups
BD65_2948	COG2205	protein histidine kinase activity
BD65_2948	COG3850	Histidine kinase
BD65_2948	COG3437	response regulator, receiver
BD65_2948	COG4999	Histidine kinase
BD65_2949	COG3706	GGDEF domain
BD65_2949	COG0745	RESPONSE REGULATOR receiver
BD65_295	COG0583	DNA-binding transcription factor activity
BD65_2952	COG2197	response regulator
BD65_2953	COG1278	Cold shock
BD65_2954	COG1278	Cold shock
BD65_2958	COG3706	GGDEF domain
BD65_2960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BD65_2963	COG1686	Belongs to the peptidase S11 family
BD65_2964	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BD65_2965	COG0772	Belongs to the SEDS family
BD65_2966	COG0768	penicillin binding
BD65_2967	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BD65_2968	COG0799	negative regulation of ribosome biogenesis
BD65_2969	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BD65_2970	COG1466	dna polymerase III delta subunit
BD65_2971	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BD65_2973	COG2888	peptidyl-tyrosine sulfation
BD65_2974	COG1126	abc transporter atp-binding protein
BD65_2975	COG0765	amino acid transport
BD65_2976	COG0765	amino acid transport
BD65_2979	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BD65_298	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BD65_2980	COG4535	Mg2 and Co2 transporter CorC
BD65_2981	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BD65_2982	COG1702	phosphate starvation-inducible protein PhoH
BD65_2983	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BD65_2984	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BD65_299	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BD65_2992	COG0367	asparagine synthase
BD65_2993	COG0647	UMP catabolic process
BD65_2994	COG1940	carbohydrate kinase activity
BD65_2994	COG1846	Transcriptional regulator
BD65_2995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BD65_2996	COG0363	glucosamine-6-phosphate deaminase activity
BD65_2997	COG2190	(PTS) system
BD65_2997	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BD65_2997	COG1263	PTS System
BD65_300	COG0671	phosphoesterase, PA-phosphatase related
BD65_3002	COG0735	belongs to the Fur family
BD65_3004	COG0840	transmembrane signaling receptor activity
BD65_3006	COG0596	Alpha beta hydrolase
BD65_3007	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BD65_3008	COG0033	Phosphoglucomutase
BD65_301	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BD65_3010	COG0745	RESPONSE REGULATOR receiver
BD65_3011	COG2205	protein histidine kinase activity
BD65_3012	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BD65_3013	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BD65_3016	COG3272	Protein of unknown function (DUF1722)
BD65_3017	COG0415	Belongs to the DNA photolyase family
BD65_3018	COG5212	phosphodiesterase
BD65_3019	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BD65_302	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BD65_3020	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BD65_3021	COG1984	allophanate hydrolase subunit 2
BD65_3022	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BD65_3027	COG2009	succinate dehydrogenase
BD65_3028	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BD65_3029	COG1053	succinate dehydrogenase
BD65_3030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BD65_3031	COG0567	Dehydrogenase, E1 component
BD65_3032	COG0508	dehydrogenase complex catalyzes the overall conversion of
BD65_3033	COG0045	succinate-CoA ligase (ADP-forming) activity
BD65_3034	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BD65_3035	COG0737	Belongs to the 5'-nucleotidase family
BD65_3036	COG1271	oxidase subunit
BD65_3037	COG1294	oxidase, subunit
BD65_3038	COG4890	Cyd operon protein YbgT
BD65_3039	COG3790	cyd operon protein YbgE
BD65_3040	COG0824	Thioesterase
BD65_3041	COG0811	peptide transport
BD65_3042	COG0848	biopolymer transport protein
BD65_3043	COG3064	Membrane
BD65_3043	COG3064	Membrane
BD65_3044	COG0823	Involved in the tonB-independent uptake of proteins
BD65_3045	COG2885	chlorophyll binding
BD65_3046	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BD65_3049	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BD65_3050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD65_3050	COG2205	protein histidine kinase activity
BD65_3053	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BD65_3054	COG0588	phosphoglycerate mutase activity
BD65_3057	COG2017	converts alpha-aldose to the beta-anomer
BD65_3059	COG1085	galactose-1-phosphate uridylyltransferase
BD65_306	COG0023	Translation Initiation Factor
BD65_3060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BD65_3062	COG3585	molybdate ion transport
BD65_3062	COG2005	Transcriptional regulator
BD65_3064	COG0725	ABC transporter, periplasmic molybdate-binding protein
BD65_3065	COG4149	molybdate abc transporter
BD65_3067	COG0561	phosphatase activity
BD65_3068	COG2706	6-phosphogluconolactonase activity
BD65_3071	COG0156	8-amino-7-oxononanoate synthase activity
BD65_3072	COG2226	methyltransferase
BD65_3073	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BD65_3075	COG0556	nucleotide-excision repair
BD65_3076	COG4628	conserved protein (DUF2132)
BD65_308	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BD65_3081	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BD65_3083	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BD65_3085	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BD65_3086	COG0314	molybdopterin synthase activity
BD65_3087	COG0670	Belongs to the BI1 family
BD65_3088	COG0842	Transport permease protein
BD65_3089	COG0842	Transport permease protein
BD65_309	COG5001	Diguanylate cyclase
BD65_309	COG3447	MASE1 domain protein
BD65_309	COG5002	protein histidine kinase activity
BD65_3090	COG1131	(ABC) transporter
BD65_3091	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BD65_3092	COG1309	transcriptional regulator
BD65_3093	COG0513	Belongs to the DEAD box helicase family
BD65_3094	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BD65_3096	COG1686	Belongs to the peptidase S11 family
BD65_3097	COG0277	FAD linked oxidase domain protein
BD65_3099	COG1403	HNH endonuclease
BD65_310	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
BD65_3101	COG2261	transglycosylase associated protein
BD65_3103	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BD65_3105	COG3639	organic phosphonate transmembrane transporter activity
BD65_3106	COG4807	Protein conserved in bacteria
BD65_3107	COG2897	thiosulfate sulfurtransferase activity
BD65_3108	COG1732	Glycine betaine
BD65_3109	COG1174	glycine betaine transport
BD65_311	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BD65_3110	COG1125	glycine betaine transport
BD65_3111	COG1174	glycine betaine transport
BD65_3112	COG0531	amino acid
BD65_3113	COG1982	Orn Lys Arg decarboxylase major
BD65_3114	COG0675	Transposase, IS605 OrfB family
BD65_3116	COG0697	spore germination
BD65_3119	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BD65_3120	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BD65_3121	COG1126	abc transporter atp-binding protein
BD65_3122	COG0765	amino acid transport
BD65_3123	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD65_3126	COG5006	permease, DMT superfamily
BD65_3127	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BD65_3128	COG2239	Acts as a magnesium transporter
BD65_313	COG4659	FMN binding
BD65_3131	COG0488	(ABC) transporter
BD65_3132	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BD65_3133	COG0303	'Molybdopterin
BD65_3137	COG0583	DNA-binding transcription factor activity
BD65_3138	COG0477	Major facilitator Superfamily
BD65_3139	COG0302	gtp cyclohydrolase
BD65_3140	COG2311	Membrane
BD65_3146	COG2949	membrane
BD65_3147	COG0281	malic enzyme
BD65_315	COG3708	Transcriptional regulator
BD65_315	COG2207	Transcriptional regulator
BD65_3151	COG1346	cytolysis
BD65_3152	COG1380	Effector of murein hydrolase LrgA
BD65_3153	COG1943	Transposase
BD65_3154	COG0675	Transposase, IS605 OrfB family
BD65_3157	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BD65_3157	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BD65_3158	COG0489	protein tyrosine kinase activity
BD65_3159	COG0572	uridine kinase
BD65_3160	COG0717	Belongs to the dCTP deaminase family
BD65_3161	COG2982	Protein involved in outer membrane biogenesis
BD65_3163	COG3069	C4-dicarboxylate transmembrane transporter activity
BD65_3164	COG1253	flavin adenine dinucleotide binding
BD65_3165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BD65_3166	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BD65_3167	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BD65_3168	COG0140	phosphoribosyl-ATP diphosphatase activity
BD65_3168	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BD65_3170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BD65_3171	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BD65_3172	COG0131	Imidazoleglycerol-phosphate dehydratase
BD65_3172	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BD65_3173	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BD65_3174	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BD65_3176	COG1943	Transposase
BD65_3179	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BD65_3180	COG0625	glutathione transferase activity
BD65_3184	COG0626	cystathionine gamma-synthase activity
BD65_3186	COG1686	Belongs to the peptidase S11 family
BD65_3187	COG1760	l-serine dehydratase
BD65_3188	COG0814	amino acid
BD65_3189	COG1349	DNA-binding transcription factor activity
BD65_3191	COG0671	phosphoesterase, PA-phosphatase related
BD65_3193	COG0569	domain protein
BD65_3193	COG2985	domain, Protein
BD65_3194	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BD65_3197	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BD65_3198	COG3842	ATPase activity
BD65_3199	COG1176	ABC-type spermidine putrescine transport system, permease component I
BD65_32	COG4372	Transposase
BD65_3200	COG1177	transmembrane transport
BD65_3203	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD65_3204	COG4160	amino acid transport
BD65_3205	COG4215	(ABC) transporter
BD65_3206	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD65_3207	COG1126	abc transporter atp-binding protein
BD65_3209	COG0393	Putative heavy-metal-binding
BD65_321	COG4657	Part of a membrane complex involved in electron transport
BD65_3210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BD65_3211	COG0702	epimerase
BD65_3212	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BD65_3213	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BD65_3214	COG1151	hydroxylamine reductase activity
BD65_3215	COG2431	L-lysine efflux transmembrane transporter activity
BD65_3217	COG2990	Protein conserved in bacteria
BD65_3219	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BD65_3221	COG1278	Cold shock
BD65_3222	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BD65_3223	COG0542	response to heat
BD65_3224	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BD65_3226	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BD65_3228	COG0492	ferredoxin-NADP+ reductase activity
BD65_3229	COG1522	sequence-specific DNA binding
BD65_323	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BD65_3230	COG1674	ftsk spoiiie
BD65_3230	COG3107	peptidoglycan biosynthetic process
BD65_3231	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BD65_3232	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BD65_3233	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BD65_3235	COG2814	Major facilitator Superfamily
BD65_3236	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BD65_3237	COG1882	Formate acetyltransferase
BD65_3238	COG2116	formate transmembrane transporter activity
BD65_3239	COG1944	ATP diphosphatase activity
BD65_3240	COG0252	asparaginase activity
BD65_3242	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BD65_3244	COG0539	negative regulation of cytoplasmic translation
BD65_3246	COG2333	competence protein COMEC
BD65_3246	COG0658	competence protein
BD65_3248	COG1663	tetraacyldisaccharide 4'-kinase activity
BD65_3249	COG5383	Protein conserved in bacteria
BD65_325	COG0673	inositol 2-dehydrogenase activity
BD65_3250	COG1278	Cold shock
BD65_3251	COG1278	Cold shock
BD65_3252	COG2835	tetraacyldisaccharide 4'-kinase activity
BD65_3254	COG3173	Aminoglycoside phosphotransferase
BD65_3255	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BD65_3256	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BD65_3257	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
BD65_3258	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
BD65_3259	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BD65_326	COG0385	Bile acid
BD65_3260	COG2989	Protein conserved in bacteria
BD65_3261	COG3108	Peptidase M15
BD65_3262	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BD65_3263	COG2200	EAL domain
BD65_3264	COG1448	Aminotransferase
BD65_3267	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BD65_327	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BD65_328	COG5339	Protein conserved in bacteria
BD65_329	COG1482	cell wall glycoprotein biosynthetic process
BD65_331	COG0114	fumarate hydratase activity
BD65_333	COG1940	carbohydrate kinase activity
BD65_334	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BD65_338	COG1742	UPF0060 membrane protein
BD65_339	COG4221	oxidoreductase activity
BD65_34	COG1943	Transposase
BD65_340	COG3023	N-Acetylmuramoyl-L-alanine amidase
BD65_345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BD65_351	COG2015	COG2015, Alkyl sulfatase and related hydrolases
BD65_356	COG1011	Hydrolase
BD65_358	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
BD65_359	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BD65_360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BD65_361	COG0589	response to stress
BD65_363	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BD65_364	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BD65_367	COG0531	amino acid
BD65_37	COG3104	oligopeptide transport
BD65_370	COG0745	RESPONSE REGULATOR receiver
BD65_371	COG2205	protein histidine kinase activity
BD65_374	COG2207	Transcriptional regulator
BD65_375	COG1881	PFAM PEBP family protein
BD65_376	COG4571	Outer membrane protease
BD65_378	COG3591	Belongs to the peptidase S1B family
BD65_380	COG1643	Atp-dependent helicase
BD65_381	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BD65_382	COG3784	Protein of unknown function (DUF1318)
BD65_385	COG2911	Protein conserved in bacteria
BD65_386	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BD65_387	COG3187	Heat shock protein
BD65_388	COG3042	response to heat
BD65_389	COG1285	pathogenesis
BD65_39	COG1560	Kdo2-lipid A biosynthetic process
BD65_391	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BD65_391	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD65_391	COG0674	pyruvate-flavodoxin oxidoreductase activity
BD65_391	COG1013	pyruvate-flavodoxin oxidoreductase activity
BD65_393	COG0598	Magnesium transport protein CorA
BD65_394	COG4166	transmembrane transport
BD65_395	COG2866	Carboxypeptidase
BD65_396	COG4948	Mandelate Racemase Muconate Lactonizing
BD65_397	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BD65_4	COG3217	Mosc domain protein beta barrel domain protein
BD65_4	COG0633	Ferredoxin
BD65_401	COG3768	UPF0283 membrane protein
BD65_402	COG3106	COG3106 Predicted ATPase
BD65_404	COG1983	PspC domain protein
BD65_406	COG1842	Phage shock protein A
BD65_407	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BD65_41	COG0628	permease
BD65_410	COG4166	transmembrane transport
BD65_411	COG4168	peptide transport system, permease
BD65_412	COG4171	peptide transport system, permease
BD65_413	COG4172	Belongs to the ABC transporter superfamily
BD65_414	COG4172	Belongs to the ABC transporter superfamily
BD65_416	COG3104	oligopeptide transport
BD65_418	COG0484	heat shock protein binding
BD65_427	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BD65_428	COG3133	Outer membrane lipoprotein
BD65_429	COG1846	Transcriptional regulator
BD65_431	COG4989	oxidoreductase activity
BD65_432	COG3313	Fe-S protein
BD65_433	COG2194	sulfuric ester hydrolase activity
BD65_434	COG1309	transcriptional regulator
BD65_435	COG1902	pentaerythritol trinitrate reductase activity
BD65_436	COG0346	lactoylglutathione lyase activity
BD65_438	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BD65_439	COG0791	NLP P60 protein
BD65_440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BD65_442	COG1609	Transcriptional regulator
BD65_443	COG0583	DNA-binding transcription factor activity
BD65_444	COG2814	Major facilitator Superfamily
BD65_445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BD65_446	COG0307	riboflavin synthase, alpha
BD65_447	COG0534	Mate efflux family protein
BD65_451	COG0469	pyruvate kinase activity
BD65_452	COG4238	major outer membrane lipoprotein
BD65_453	COG1376	ErfK ybiS ycfS ynhG family protein
BD65_453	COG1388	LysM domain
BD65_454	COG2166	iron-sulfur cluster assembly
BD65_456	COG0719	Fe-S assembly protein
BD65_457	COG0396	ATPase activity
BD65_458	COG0719	Fe-S assembly protein
BD65_459	COG0316	Belongs to the HesB IscA family
BD65_46	COG0418	dihydroorotase activity
BD65_461	COG2050	protein possibly involved in aromatic compounds catabolism
BD65_462	COG0247	lactate metabolic process
BD65_462	COG0277	FAD linked oxidase domain protein
BD65_463	COG0628	permease
BD65_464	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BD65_464	COG0574	Belongs to the PEP-utilizing enzyme family
BD65_465	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BD65_466	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BD65_467	COG4771	TonB-dependent receptor
BD65_468	COG3720	iron ion transport
BD65_469	COG4558	Periplasmic binding protein
BD65_47	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BD65_470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BD65_471	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BD65_473	COG0095	Lipoate-protein ligase
BD65_474	COG0791	NLP P60 protein
BD65_475	COG2076	Multidrug Resistance protein
BD65_476	COG2076	Multidrug Resistance protein
BD65_477	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BD65_480	COG0463	Glycosyl transferase, family 2
BD65_481	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BD65_482	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
BD65_483	COG4139	cobalamin transport
BD65_484	COG4974	Belongs to the 'phage' integrase family
BD65_487	COG2184	nucleotidyltransferase activity
BD65_488	COG2184	nucleotidyltransferase activity
BD65_49	COG1530	ribonuclease E activity
BD65_490	COG0776	regulation of translation
BD65_5	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BD65_5	COG0116	Belongs to the methyltransferase superfamily
BD65_50	COG0564	pseudouridine synthase activity
BD65_505	COG0803	Belongs to the bacterial solute-binding protein 9 family
BD65_506	COG1121	(ABC) transporter
BD65_507	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BD65_508	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BD65_512	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BD65_513	COG1988	membrane-bound metal-dependent
BD65_515	COG3023	N-Acetylmuramoyl-L-alanine amidase
BD65_517	COG2814	Major facilitator Superfamily
BD65_518	COG0501	Belongs to the peptidase M48B family
BD65_519	COG0793	Belongs to the peptidase S41A family
BD65_52	COG1399	metal-binding, possibly nucleic acid-binding protein
BD65_521	COG1956	GAF domain-containing protein
BD65_522	COG2995	paraquat-inducible protein a
BD65_523	COG3008	intermembrane lipid transfer
BD65_524	COG2203	Gaf domain
BD65_524	COG3706	GGDEF domain
BD65_524	COG4251	negative regulation of phosphorylation
BD65_524	COG5001	Diguanylate cyclase
BD65_53	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BD65_541	COG1276	copper resistance
BD65_542	COG2372	response to copper ion
BD65_543	COG1528	Iron-storage protein
BD65_548	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BD65_549	COG1770	oligopeptidase
BD65_55	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BD65_553	COG3141	response to X-ray
BD65_554	COG0513	Belongs to the DEAD box helicase family
BD65_558	COG0494	nUDIX hydrolase
BD65_559	COG1760	l-serine dehydratase
BD65_56	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BD65_561	COG1253	flavin adenine dinucleotide binding
BD65_562	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BD65_562	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BD65_563	COG3715	PTS system
BD65_564	COG3716	PTS system mannose fructose sorbose family IID component
BD65_565	COG4811	Protein of unknown function (DUF986)
BD65_566	COG1971	Probably functions as a manganese efflux pump
BD65_57	COG1028	Short-chain dehydrogenase reductase Sdr
BD65_570	COG1960	acyl-CoA dehydrogenase activity
BD65_572	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BD65_578	COG2226	methyltransferase
BD65_579	COG0768	penicillin binding
BD65_58	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BD65_581	COG1278	Cold shock
BD65_584	COG1113	amino acid transport
BD65_59	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BD65_591	COG2207	Transcriptional regulator
BD65_594	COG1132	(ABC) transporter
BD65_596	COG5001	Diguanylate cyclase
BD65_596	COG4251	negative regulation of phosphorylation
BD65_596	COG2203	Gaf domain
BD65_596	COG3706	GGDEF domain
BD65_6	COG0488	(ABC) transporter
BD65_60	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BD65_600	COG1181	Belongs to the D-alanine--D-alanine ligase family
BD65_604	COG1278	Cold shock
BD65_608	COG1917	Cupin 2, conserved barrel domain protein
BD65_608	COG2169	Transcriptional regulator
BD65_609	COG1447	Phosphotransferase system cellobiose-specific component IIA
BD65_61	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BD65_610	COG2723	6-phospho-beta-galactosidase activity
BD65_611	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BD65_612	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BD65_613	COG1187	pseudouridine synthase activity
BD65_614	COG3122	Protein conserved in bacteria
BD65_618	COG2235	arginine
BD65_62	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BD65_622	COG0076	glutamate decarboxylase activity
BD65_623	COG0531	amino acid
BD65_629	COG2153	protein acetylation
BD65_63	COG0470	DNA polymerase III
BD65_630	COG1943	Transposase
BD65_631	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BD65_64	COG0084	hydrolase, TatD family'
BD65_640	COG0840	transmembrane signaling receptor activity
BD65_647	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BD65_648	COG0322	excinuclease ABC activity
BD65_649	COG2197	response regulator
BD65_65	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BD65_65	COG1263	PTS System
BD65_653	COG1113	amino acid transport
BD65_654	COG1982	Orn Lys Arg decarboxylase major
BD65_655	COG0531	amino acid
BD65_656	COG3710	Transcriptional regulator
BD65_657	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BD65_658	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BD65_658	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BD65_658	COG0506	proline dehydrogenase activity
BD65_66	COG0537	adenosine 5'-monophosphoramidase activity
BD65_662	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BD65_664	COG1191	sigma factor activity
BD65_67	COG5633	Lipoprotein
BD65_672	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BD65_673	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BD65_675	COG1677	Flagellar hook-basal body complex protein FliE
BD65_677	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BD65_679	COG1157	protein secretion by the type III secretion system
BD65_68	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
BD65_680	COG2882	bacterial-type flagellum organization
BD65_682	COG1580	Controls the rotational direction of flagella during chemotaxis
BD65_69	COG0510	thiamine kinase activity
BD65_690	COG1256	bacterial-type flagellum assembly
BD65_694	COG4786	Flagellar basal body rod
BD65_696	COG1749	Flagellar hook protein flgE
BD65_697	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BD65_698	COG1558	bacterial-type flagellum-dependent cell motility
BD65_699	COG1815	bacterial-type flagellum-dependent cell motility
BD65_7	COG2995	paraquat-inducible protein a
BD65_701	COG2747	anti-sigma28 factor FlgM
BD65_702	COG3418	PFAM FlgN family protein
BD65_704	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BD65_705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BD65_708	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BD65_709	COG0745	RESPONSE REGULATOR receiver
BD65_71	COG3150	esterase
BD65_711	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BD65_712	COG0840	transmembrane signaling receptor activity
BD65_713	COG0840	transmembrane signaling receptor activity
BD65_714	COG0835	chemotaxis
BD65_715	COG0643	Histidine kinase
BD65_715	COG2198	Histidine kinase
BD65_716	COG1360	Flagellar Motor Protein
BD65_72	COG1252	NADH dehydrogenase
BD65_720	COG0589	response to stress
BD65_721	COG1285	pathogenesis
BD65_722	COG0840	transmembrane signaling receptor activity
BD65_724	COG1278	Cold shock
BD65_726	COG3321	synthase
BD65_726	COG1028	Short-chain dehydrogenase reductase Sdr
BD65_726	COG0604	alcohol dehydrogenase
BD65_73	COG3134	Outer membrane lipoprotein
BD65_736	COG0471	metal ion transport
BD65_739	COG3051	citrate lyase alpha subunit
BD65_74	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BD65_740	COG2301	Belongs to the HpcH HpaI aldolase family
BD65_741	COG3052	prosthetic group binding
BD65_742	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
BD65_743	COG3290	protein histidine kinase activity
BD65_744	COG4565	transcriptional regulatory protein
BD65_747	COG2271	Major facilitator Superfamily
BD65_748	COG1840	ABC-type Fe3 transport system, periplasmic component
BD65_75	COG4591	ABC-type transport system involved in lipoprotein release permease component
BD65_750	COG3842	ATPase activity
BD65_754	COG1289	transmembrane transporter activity
BD65_756	COG2925	Exonuclease
BD65_757	COG0531	amino acid
BD65_759	COG4771	TonB-dependent receptor
BD65_761	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BD65_763	COG0833	amino acid
BD65_765	COG1943	Transposase
BD65_766	COG0675	Transposase, IS605 OrfB family
BD65_767	COG2855	membrane
BD65_768	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BD65_769	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BD65_769	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BD65_769	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BD65_77	COG4591	ABC-type transport system involved in lipoprotein release permease component
BD65_770	COG1105	Belongs to the carbohydrate kinase PfkB family
BD65_773	COG3005	denitrification pathway
BD65_774	COG0243	molybdopterin cofactor binding
BD65_777	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BD65_778	COG1312	Catalyzes the dehydration of D-mannonate
BD65_779	COG0246	Mannitol dehydrogenase
BD65_781	COG0523	cobalamin synthesis protein
BD65_782	COG0671	phosphoesterase, PA-phosphatase related
BD65_783	COG0791	NLP P60 protein
BD65_784	COG2200	EAL domain
BD65_785	COG4166	transmembrane transport
BD65_786	COG4174	ABC transporter (Permease)
BD65_787	COG4239	(ABC) transporter, permease
BD65_788	COG4172	Belongs to the ABC transporter superfamily
BD65_79	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BD65_790	COG2814	Major facilitator Superfamily
BD65_791	COG1187	pseudouridine synthase activity
BD65_792	COG1061	Type III restriction enzyme res subunit
BD65_795	COG3082	Protein of unknown function (DUF1414)
BD65_796	COG3083	sulfuric ester hydrolase activity
BD65_798	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BD65_8	COG3008	intermembrane lipid transfer
BD65_8	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BD65_803	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BD65_804	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BD65_808	COG1943	Transposase
BD65_809	COG2223	nitrite transmembrane transporter activity
BD65_81	COG2850	peptidyl-arginine hydroxylation
BD65_810	COG0642	Histidine kinase
BD65_810	COG2198	Histidine kinase
BD65_812	COG2205	protein histidine kinase activity
BD65_812	COG0784	Response regulator, receiver
BD65_814	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BD65_815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BD65_817	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BD65_819	COG4574	serine-type endopeptidase inhibitor activity
BD65_82	COG2205	protein histidine kinase activity
BD65_821	COG2246	polysaccharide biosynthetic process
BD65_824	COG0814	amino acid
BD65_829	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BD65_83	COG0745	RESPONSE REGULATOR receiver
BD65_830	COG0596	Alpha beta hydrolase
BD65_831	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BD65_832	COG1169	isochorismate synthase
BD65_833	COG4575	ribosome binding
BD65_836	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD65_837	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BD65_839	COG0839	Belongs to the complex I subunit 6 family
BD65_840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD65_841	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BD65_842	COG1034	ATP synthesis coupled electron transport
BD65_844	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BD65_846	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD65_847	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD65_848	COG0583	DNA-binding transcription factor activity
BD65_849	COG0436	Aminotransferase
BD65_85	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BD65_850	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BD65_851	COG0471	metal ion transport
BD65_851	COG0490	domain, Protein
BD65_853	COG3013	Belongs to the UPF0304 family
BD65_854	COG3092	negative regulation of chromosome organization
BD65_856	COG0857	belongs to the CobB CobQ family
BD65_856	COG0280	phosphate acetyltransferase
BD65_857	COG1609	Transcriptional regulator
BD65_86	COG2915	High frequency lysogenization protein hflD homolog
BD65_860	COG3037	sugar-specific permease SgaT UlaA
BD65_861	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BD65_862	COG0622	Phosphoesterase
BD65_864	COG0625	glutathione transferase activity
BD65_865	COG1090	epimerase
BD65_867	COG4160	amino acid transport
BD65_868	COG4215	(ABC) transporter
BD65_869	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD65_87	COG0482	sulfurtransferase activity
BD65_870	COG0163	prenyltransferase activity
BD65_871	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BD65_872	COG1286	toxin biosynthetic process
BD65_873	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BD65_874	COG0285	dihydrofolate synthase activity
BD65_876	COG0586	Pfam SNARE associated Golgi protein
BD65_878	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BD65_883	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BD65_884	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BD65_89	COG1187	pseudouridine synthase activity
BD65_890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BD65_893	COG3101	peptidyl-lysine hydroxylation
BD65_894	COG0730	response to heat
BD65_895	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BD65_897	COG2890	protein-(glutamine-N5) methyltransferase activity
BD65_898	COG2840	Smr protein MutS2
BD65_899	COG2062	phosphohistidine phosphatase, SixA
BD65_9	COG3009	Protein conserved in bacteria
BD65_90	COG0538	isocitrate dehydrogenase activity
BD65_900	COG1024	Enoyl-CoA hydratase
BD65_900	COG1250	3-hydroxyacyl-CoA dehydrogenase
BD65_901	COG0183	Belongs to the thiolase family
BD65_902	COG3691	Protein conserved in bacteria
BD65_905	COG3088	subunit of a heme lyase
BD65_905	COG4235	cytochrome complex assembly
BD65_906	COG3088	subunit of a heme lyase
BD65_906	COG4235	cytochrome complex assembly
BD65_907	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BD65_908	COG1138	Cytochrome C-type biogenesis protein
BD65_909	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BD65_91	COG3916	Acyl-homoserine-lactone synthase
BD65_910	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BD65_911	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BD65_912	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BD65_916	COG2824	Alkylphosphonate utilization operon protein PhnA
BD65_917	COG2951	lytic endotransglycosylase activity
BD65_919	COG3038	cytochrome b561
BD65_92	COG2771	luxR family
BD65_920	COG0436	Aminotransferase
BD65_922	COG3275	phosphorelay sensor kinase activity
BD65_923	COG3279	Response regulator of the LytR AlgR family
BD65_924	COG2223	nitrite transmembrane transporter activity
BD65_925	COG0837	glucose binding
BD65_929	COG1914	H( )-stimulated, divalent metal cation uptake system
BD65_930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BD65_94	COG2723	6-phospho-beta-galactosidase activity
BD65_941	COG3530	Putative quorum-sensing-regulated virulence factor
BD65_942	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BD65_944	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
BD65_945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BD65_946	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BD65_948	COG2190	(PTS) system
BD65_949	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BD65_95	COG0339	signal peptide processing
BD65_951	COG4208	sulfate ABC transporter
BD65_952	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BD65_953	COG4150	thiosulfate binding
BD65_955	COG1737	Transcriptional regulator
BD65_956	COG2731	YhcH YjgK YiaL family protein
BD65_959	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BD65_96	COG0840	transmembrane signaling receptor activity
BD65_960	COG2837	iron assimilation
BD65_962	COG3111	PFAM Bacterial OB fold (BOF) protein
BD65_965	COG1671	Belongs to the UPF0178 family
BD65_966	COG0281	malic enzyme
BD65_966	COG0280	phosphate acetyltransferase
BD65_967	COG0494	nUDIX hydrolase
BD65_968	COG3005	denitrification pathway
BD65_969	COG3043	anaerobic respiration
BD65_97	COG3493	citrate carrier protein
BD65_970	COG0243	molybdopterin cofactor binding
BD65_971	COG3062	negative regulation of establishment of protein localization
BD65_972	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BD65_972	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
BD65_973	COG2197	response regulator
BD65_975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BD65_976	COG1605	Chorismate mutase
BD65_978	COG1393	Belongs to the ArsC family
BD65_979	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BD65_98	COG4565	transcriptional regulatory protein
BD65_980	COG1876	peptidase activity
BD65_982	COG0400	carboxylic ester hydrolase activity
BD65_986	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BD65_987	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BD65_988	COG2716	regulation of RNA biosynthetic process
BD65_989	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BD65_99	COG3290	protein histidine kinase activity
BD65_990	COG0628	permease
BD65_991	COG4783	chaperone-mediated protein folding
BD65_992	COG1393	Belongs to the ArsC family
BD65_993	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BD65_994	COG2233	PERMEase
BD65_995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BD65_996	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BD65_997	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BD65_998	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins